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Neuroendocrine tumors.

February - March 2013


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TÍTULO / TITLE:  - Novel tandem germline RET proto-oncogene mutations in a patient with multiple endocrine neoplasia type 2B: Report of a case and a literature review of tandem RET mutations with in silico analysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Head Neck. 2013 Mar 6. doi: 10.1002/hed.23241.

            ●● Enlace al texto completo (gratuito o de pago) 1002/hed.23241

AUTORES / AUTHORS:  - Nakao KT; Usui T; Ikeda M; Mori Y; Yamamoto T; Kawashima ST; Nanba K; Yuno A; Tamanaha T; Tagami T; Naruse M; Asato R; Shimatsu A

INSTITUCIÓN / INSTITUTION:  - Department of Endocrinology and Metabolism, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan.

RESUMEN / SUMMARY:  - BACKGROUND: Multiple endocrine neoplasia type 2B (MEN2B) is the rarest and most aggressive form of MEN2. MEN2B cases usually carry either an M918T or A883T mutation of the RET, but to date, there are 3 atypical MEN2B caused by tandem mutations. METHODS AND RESULTS: A 32-year-old woman with no family history of medullary thyroid carcinoma (MTC) presented with a neck tumor and multiple mucosal nodules. She was diagnosed with MEN2B. Genetic analyses of RET revealed that she had 2 mutations, Q781R and V804M. Subclone and genetic analyses revealed that Q781R was on the paternal allele and V804M was a de novo. In silico analysis of the tandem mutations showed a high prediction score. CONCLUSIONS: We describe  a novel combination of tandem RET mutations (Q781R/V804M) in a MEN2B-like patient. In silico analysis showed a high prediction score, which was compatible  with the clinical phenotype in the present case. © 2012 Wiley Periodicals, Inc. Head Neck, 2012.




TÍTULO / TITLE:  - Pancreatic well-differentiated neuroendocrine neoplasms (pWDNENs): what place for everolimus and sunitinib derived from ESMO clinical practice guidelines in the therapeutic algorithm?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Oncol. 2013 Mar 13.

            ●● Enlace al texto completo (gratuito o de pago) 1093/annonc/mdt102

AUTORES / AUTHORS:  - Pusceddu S; Buzzoni R; De Braud F

INSTITUCIÓN / INSTITUTION:  - Medical Oncology Unit;




TÍTULO / TITLE:  - Microcystic/reticular schwannoma of the proximal sigmoid colon: case report with  review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Pathol Lab Med. 2013 Feb;137(2):284-8. doi: 10.5858/arpa.2011-0386-CR.

            ●● Enlace al texto completo (gratuito o de pago) 5858/arpa.2011-0386-CR

AUTORES / AUTHORS:  - Trivedi A; Ligato S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Hartford Hospital, Hartford, Connecticut 06102, USA. atrivedi@harthosp.org

RESUMEN / SUMMARY:  - We report a case of microcystic/reticular schwannoma of the proximal sigmoid colon in a 61-year-old man. A 12-mm polyp was detected while the patient was undergoing screening for colorectal neoplasm. This rare variant of schwannoma was initially described in 2008 and shows a predilection for the visceral organs, predominantly the gastrointestinal tract. We also review 11 other reported cases  of microcystic/reticular schwannomas in the gastrointestinal tract. Unlike conventional gastrointestinal schwannomas, which are more common in the stomach,  this variant appears to be more common in the large intestine. Histologic examination of this polyp showed predominant lipoblast-like vacuolated cells within a myxoid stroma with focal spindle cell areas. Features suggestive of malignancy, like nuclear pleomorphism, mitosis, or necrosis, were absent. Immunohistochemistry for S100 protein showed strong nuclear and cytoplasmic positivity, whereas cytokeratin and CD117 stains were negative. It is important to entertain microcystic/reticular schwannoma in the differential diagnosis of a  signet ring cell adenocarcinoma or a myxoid gastrointestinal stromal tumor, particularly on small biopsy specimens.




TÍTULO / TITLE:  - Introduction: recent advances in the genetics, diagnosis, and treatment of neuroendocrine tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Semin Oncol. 2013 Feb;40(1):1-3. doi: 10.1053/j.seminoncol.2012.12.001.

            ●● Enlace al texto completo (gratuito o de pago) 1053/j.seminoncol.2012.12.001

AUTORES / AUTHORS:  - Bergsland EK




TÍTULO / TITLE:  - Neuroendocrine tumors of larynx—two case reports and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Coll Antropol. 2012 Nov;36 Suppl 2:173-8.

AUTORES / AUTHORS:  - Caric T; Bilic M; Bilic LK; Prgomet D; Kovacic J; Grahovac IT; Hutinec Z

INSTITUCIÓN / INSTITUTION:  - University of Zagreb, Dubrava University Hospital, Department of ENT, Head and Neck Surgery, Zagreb, Croatia. tcaric@gmail.com

RESUMEN / SUMMARY:  - Neuroendocrine tumors (NET) of the larynx are rare and heterogenous group, with much confusion about nature and classification of these neoplasms in the past. Diagnosis is based primarily on light microscopy and confirmed by immunohistochemistry and electron microscopy. A classification in 4 different types; paraganglioma, typical carcinoid, atypical carcinoid and small cell neuroendocrine carcinoma (SCNC) is a current consensus. Thorough diagnostic and a proper classification of neuroendocrine neoplasms are of paramount importance—prognosis and treatment differ significantly. We present two cases: 63-year old patient with SCNC of the larynx and a 53-year old patient with atypical carcinoid of the larynx. OctreoScan is useful tools for diagnostics and  follow up of the patients and it is predictive for effectiveness of octreotide therapy.




TÍTULO / TITLE:  - The Merkel cell polyomavirus and its involvement in Merkel cell carcinoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dermatol Surg. 2013 Feb;39(2):232-8. doi: 10.1111/dsu.12079.

            ●● Enlace al texto completo (gratuito o de pago) 1111/dsu.12079

AUTORES / AUTHORS:  - Amber K; McLeod MP; Nouri K

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida, USA.

RESUMEN / SUMMARY:  - BACKGROUND: The discovery of the Merkel cell polyomavirus (MCV) in a large number of Merkel cell carcinomas (MCCs) has led to many investigations into its potential role as an oncovirus. Many studies have recently explored the differences between MCCs infected and not infected with MCV. OBJECTIVE: To review the role of MCV in MCC and its potential to influence diagnosis, prognosis, and treatment. METHODS AND MATERIALS: An extensive literature search was performed on MCV and its relationship with other polyomaviruses and MCC. The immune system’s role in MCC was also investigated. RESULTS: We included 60 articles regarding MCC and MCV and seven pertinent to general processes involved with MCC and MCV. CONCLUSION: Merkel cell polyomavirus appears to affect many aspects of MCC. An understanding of this virus may aid in future therapy options and current pathology protocols in diagnosing MCC. The host’s immune function appears to affect MCV’s ability to cause cellular transformation leading to MCC.




TÍTULO / TITLE:  - Staging of gastroenteropancreatic neuroendocrine tumors: how we do it based on an evidence-based approach.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Mar;37(2):194-200. doi: 10.1016/j.clinimag.2012.05.006. Epub 2012 Jun 15.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.05.006

AUTORES / AUTHORS:  - McDermott S; O’Neill AC; Skehan SJ

INSTITUCIÓN / INSTITUTION:  - St Vincent’s University Hospital, Elm Park, Dublin 4, Ireland. Electronic address: mcdermottshaunagh@gmail.com.

RESUMEN / SUMMARY:  - In contrast to other common types of malignant tumors, the vast majority of gastroenteropancreatic neuroendocrine tumors are well differentiated and slowly growing with only a minority showing aggressive behavior. It is important to accurately stage patients radiologically so the correct treatment can be implemented and to improve prognosis. In this article, we critically appraise the current literature in an effort to establish the current role of radiologic imaging in the staging of neuroendocrine tumors. We also discuss our protocol for staging neuroendocrine tumors.




TÍTULO / TITLE:  - Metastatic paraganglioma of the spine: Case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Neurol Neurosurg. 2013 Feb 8. pii: S0303-8467(13)00021-8. doi: 10.1016/j.clineuro.2013.01.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clineuro.2013.01.006

AUTORES / AUTHORS:  - Lau D; La Marca F; Camelo-Piragua S; Park P

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.

RESUMEN / SUMMARY:  - Paragangliomas are relatively rare tumors, accounting for only about 0.3% of all  neoplasms. Most paragangliomas are defined as benign in nature, but 10-20% possess metastatic potential. There have been scattered reports of metastatic paraganglioma in the literature, but in rare circumstances, paragangliomas can metastasize to the spinal column causing destruction or compression of the spinal cord, clinically manifesting as pain or neurological deficit. We report a case of metastatic paraganglioma in which a 47-year-old man had spinal metastasis from a  primary abdominal paraganglioma and was found to be positive for SDHB mutation, portraying negative implications for prognosis. Long-term follow-up is reported.  In addition, we review the literature on the topic of metastatic paraganglioma, management of paragangliomas involving spine, and touch on the importance of the  presence of SDHB mutations in these cases.




TÍTULO / TITLE:  - Needle core biopsy in the diagnosis of pediatric thyroid neoplasms: a single institution retrospective review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Surg Int. 2013 Feb 15.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00383-013-3278-8

AUTORES / AUTHORS:  - Yunker WK; Hassan SF; Ferrell LB; Hicks MJ; Giannoni CM; Wesson DE; Cassady CI; Hernandez JA; Brandt ML; Lopez ME

INSTITUCIÓN / INSTITUTION:  - Bobby R. Alford Department of Otolaryngology, Baylor College of Medicine, Houston, TX, USA.

RESUMEN / SUMMARY:  - PURPOSE: Our institution routinely utilizes needle core biopsy (NCB), instead of  fine needle aspiration, in the evaluation of pediatric thyroid nodules. This practice initially arose from limited cytopathology services in our hospital. Given the lack of information regarding the utility of NCB in diagnosing pediatric thyroid neoplasms, we set out to review our institution’s experience with this technique. METHODS: We performed a single institution retrospective chart review of all children who underwent thyroidectomy for primary thyroid pathology. RESULTS: Seventy-four patients, with a mean age of 12.9 +/- 4.5 (SD) years, underwent partial or total thyroidectomy between 2002 and 2010. Seven of these patients had medically refractive hyperthyroidism. The remaining 67 patients had one or more thyroid nodules as identified by ultrasound. 24 (36 %) of these cases were malignant on final pathology. 14 (58 %) of the malignant cases were papillary thyroid carcinoma. 46 of the thyroid nodule cases underwent  pre-operative NCB. Biopsy results for these patients were non-diagnostic in 6 (13 %), benign in 11 (24 %), atypical in 17 (37 %), and malignant in 12 (26 %). There were no complications arising from NCB. Sensitivity of NCB for diagnosing papillary carcinoma (PC) and follicular neoplasm was calculated at 0.88 (0.47-1.0, 95 % CI) and 0.84 (0.60-0.97, 95 % CI), respectively. Of the 28 patients not undergoing preoperative NCB, 12 underwent hemithyroidectomy, with one patient (8 %) requiring completion thyroidectomy for PC. Overall, the sensitivity of NCB in diagnosing PC and follicular thyroid neoplasms was 0.85 (0.55-0.99, 95 % CI), while the specificity was 0.63 (0.42-0.82, 95 % CI). CONCLUSIONS: Needle core biopsy appears to have a low rate of associated complications, and its sensitivity for diagnosing PC and follicular neoplasm is comparable to what has been reported for fine needle aspiration biopsy in a similar patient population.




TÍTULO / TITLE:  - Surgical treatment and survival in patients with liver metastases from neuroendocrine tumors: a meta-analysis of observational studies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Hepatol. 2013;2013:235040. doi: 10.1155/2013/235040. Epub 2013 Feb 20.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/235040

AUTORES / AUTHORS:  - Bacchetti S; Bertozzi S; Londero AP; Uzzau A; Pasqual EM

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, AOU “Santa Maria della Misericordia”, Piazzale SM della Misericordia 15, I-33100 Udine, Italy.

RESUMEN / SUMMARY:  - Introduction. The role of hepatic resection in patients with liver metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is still poorly defined. Therefore, we examined the results obtained with surgical resection and  other locoregional or systemic therapies by reviewing the recent literature on this topic. We performed the meta-analysis for comparing surgical resection of hepatic metastases with other treatments. Materials and Methods. In this systematic review and meta-analysis of observational studies, the literature search was undertaken between 1990 and 2012 looking for studies evaluating the different survivals between patients treated with surgical resection of hepatic metastases and with other surgical or nonsurgical therapies. The studies were evaluated for quality, publication bias, and heterogeneity. Pooled hazard ratio (HR) estimates and 95% confidence intervals (CI.95) were calculated using fixed-effects model. Results. We selected six studies in the review, five of which were suitable for meta-analysis. We found a significant longer survival in  patients treated with hepatic resection than embolisation HR 0.34 (CI.95 0.21-0.55) or all other nonsurgical treatments HR 0.45 (CI.95 0.34-0.60). Only one study compared surgical resection with liver transplantation and meta-analysis was not feasible. Conclusions. Our meta-analysis provides evidence  supporting the hypothesis that hepatic resection increases overall survival in patients with liver metastases from GEP-NETs. Further randomized clinical trials  are needed to confirm these findings and it would be desirable to identify new markers to properly select patients for surgical treatment.



TÍTULO / TITLE:  - Pheochromocytoma causing cardiomyopathy, ischemic stroke and acute arterial thrombosis: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Conn Med. 2013 Feb;77(2):95-8.

AUTORES / AUTHORS:  - Vindenes T; Crump N; Casenas R; Wood K

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, Danbury Hospital, Danbury, CT, USA.

RESUMEN / SUMMARY:  - Pheochromocytoma is a rare catecholamine secreting neuroendocrine tumor with an estimated annual incidence of one to four per million and prevalence among hypertensive patients of 0.1 to 0.6%. The symptoms and signs of pheochromocytoma  include the classic triad of episodic headache, increased sweating, and palpitations. These are as a result of an uncontrolled release of catecholamines. There exist only a small number of reports of pheochromocytoma simulating hypertrophic obstructive cardiomyopathy, few reports of pheochromocytoma-induced  ischemic stroke and only two reported cases with pheochromocytoma-induced arterial thrombosis. We present a case of multiple, rare clinical complications of pheochromocytoma occurring in the same patient and the review of literature of these complications.




TÍTULO / TITLE:  - Genetic aspects of pheochromocytoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Adv Clin Exp Med. 2012 Nov-Dec;21(6):821-9.

AUTORES / AUTHORS:  - Kolackov K; Tupikowski K; Bednarek-Tupikowska G

INSTITUCIÓN / INSTITUTION:  - Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland. katarzyna.kolackov@gmail.com

RESUMEN / SUMMARY:  - Pheochromocytomas are derived from chromaffin cells of the adrenal medulla which  synthesize and secrete catecholamines, thus affecting the cardiovascular system and metabolic processes. Pheochromocytoma is a tumor of the following multicarcinoma hereditary syndromes: type 2 multiple endocrine neoplasia, von Hippel-Lindau disease, type 1 neurofibromatosis and the pheochromocytomas/paragangliomas syndrome. Pheochromocytomas are relatively rare, and because of non-specific manifestation of these tumors and the possible lack of signs and symptoms for extended periods of time, the diagnosis may be delayed, which may, in turn, lead to death. Pheochromocytomas may occur sporadically. However, due to the frequent incidence of hereditary forms of these cancers, the  presymptomatic genetic testing of family members with a positive family history is indicated, thus allowing for selecting people with higher risk of cancer. Early detection of the syndrome and the coexisting tumors (which may be malignant) may lead to a correct diagnosis, regular surveillance, preventive examinations and implementation of appropriate early treatment. Recent examinations have shown significant involvement of RET, VHL, NF1, SDHB and SDHD as well as the newly discovered KIF1Bbeta, TMEM127 and MAX genes in pathogenesis  of these tumors. The microarray-gene expression studies, based on the analysis of cellular pathways, have revealed two distinct clusters indicating two different routes of tumorgenesis. The genotype-phenotype correlations are still being studied and future research can give us clearer information about the function of these genes, which may prove crucial from the clinical point of view.



TÍTULO / TITLE:  - Current concepts in the diagnosis and management of poorly differentiated gastrointestinal neuroendocrine carcinomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Endokrynol Pol. 2013;64(1):60-72.

AUTORES / AUTHORS:  - Koumarianou A; Chatzellis E; Boutzios G; Tsavaris N; Kaltsas G

RESUMEN / SUMMARY:  - Poorly differentiated neuroendocrine carcinomas (PDNEC) are rare tumours that can originate from any site of the gastrointestinal tract exhibiting an overall aggressive behaviour that may vary between tumours according to the degree of cellular proliferation. The majority of PDNEC are locally advanced or metastatic  at presentation, and are only infrequently associated with secretory hormonal syndromes. PDNEC exhibit aggressive histological features (high mitotic rate, high Ki67 labelling index and presence of necrosis) and are further subdivided into two morphological subgroups, small and large cell variants. As PDNEC express somatostatin receptors less frequently, somatostatin receptor scintigraphy is usually negative, whereas 18F-fluorodeoxyglucose positron emission tomography appears to be the best method of evaluating disease spread and guiding further treatment. PDNEC have traditionally been treated similarly to small cell lung carcinoma, although they show a number of different clinical and histopathologic  features. First line systemic chemotherapy with a platinum-based agent and etoposide is used for patients with metastatic disease, leading to variable response rates that are often of relative short duration. Sequential or concurrent chemoradiation is recommended for patients with locoregional disease.  In patients with localised disease, complete surgical resection should be offered followed by adjuvant treatment (chemotherapy with or without radiotherapy); the value of neoadjuvant chemotherapy has not been evaluated as yet. The role of second line therapies is evolving, with temozolomide being a promising agent. However, the majority of data regarding PDNEC is hampered by the small number of  series and their retrospective nature, making it important that multicentre co-operative studies be performed.




TÍTULO / TITLE:  - Gastric carcinoids and therapeutic options. Case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointestin Liver Dis. 2013 Mar;22(1):93-6.

AUTORES / AUTHORS:  - Dobru D; Boeriu A; Mocan S; Pascarenco O; Boeriu C; Molnar C

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, University of Medicine and Pharmacy Targu Mures,Targu Mures, Romania ;Email: cboeriu@gmail.com.

RESUMEN / SUMMARY:  - Neuroendocrine tumors (carcinoids) are tumors originating from neuroendocrine cells. The distinction between different types of gastric carcinoids is important for their management. We present the case of a 38-year old woman with type 1 gastric neuroendocrine tumors (NETs) associated with autoimmune atrophic gastritis. The management of these tumors has not been yet codified and different therapeutic strategies have been suggested. A proper evaluation before therapy is indicated in order to rule out both the malignant transformation as well as the presence of synchronous lesions, such as dysplasia or gastric adenocarcinoma. We  describe our diagnostic and therapeutic strategies with references to previously  published reports.



TÍTULO / TITLE:  - Multidisciplinary management of vestibular schwannomas: state of the art.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - B-ENT. 2012;8(4):235-40.

AUTORES / AUTHORS:  - Somers T; Van Havenbergh T

INSTITUCIÓN / INSTITUTION:  - Department of ENT, Sint-Augustinus Hospital, Wilrijk, Antwerp, Belgium. Thomas.somers@gza.be

RESUMEN / SUMMARY:  - The preferred setting for the treatment for vestibular schwannoma these days is multidisciplinary and multimodal. A balance has to be struck between a wait-and-scan attitude and a more active approach (surgery or radiotherapy). An initial wait-and-scan attitude is a reasonable management option because many tumours do not grow during a prolonged period of observation. The different surgical approaches may or may not involve attempts to preserve hearing. Stereotactic radiotherapy as treatment of choice is often considered in the elderly patient presenting with a vestibular schwannoma smaller than 2.5 cm with  documented growth. This paper will review current treatment modalities and the respective pros and cons. A decisional algorithm as currently adopted by our skull base team is presented at the end of the paper.



TÍTULO / TITLE:  - Results and summary of voting among the audience during presentation and discussion of Medullary Thyroid Carcinoma clinical guidelines prepared by American Thyroid Association.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Thyroid Res. 2013 Mar 14;6 Suppl 1:S12. doi: 10.1186/1756-6614-6-S1-S12. Epub 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1756-6614-6-S1-S12

AUTORES / AUTHORS:  - Feldt-Rasmussen U; Soderstrom F

INSTITUCIÓN / INSTITUTION:  - Department of Medical Endocrinology, National University Hospital, Copenhagen University, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. ufeldt@rh.dk.

RESUMEN / SUMMARY:  - The one-day ETA-CRN meeting, preceding the ETA meeting in Lisbon, was planned in  advance to provide a thorough assessment of the European response to the published American Thyroid Association MTC guidelines. During the meeting, following each of the European speakers, a series of questions, related to the specific aspect, were presented to the audience. The responses from the audience  were collected by an AudioResponseSystem (ARS voting system). The results of the  voting showed in summary that European expert opinion leaders and an audience of  specialists in treatment of Medullary Carcinoma welcomes the American Guidelines  on the management of MTC, but simultaneously only partially agrees with some of the statements in the guidelines.



TÍTULO / TITLE:  - Isolated peritoneal carcinomatosis from gastrointestinal tract carcinoid tumor: two case reports and a review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gastrointest Cancer Res. 2013 Jan;6(1):27-30.

AUTORES / AUTHORS:  - Kahan S; Teppara N; Babkowski R; Dong Xda E

INSTITUCIÓN / INSTITUTION:  - Department of Surgery.



TÍTULO / TITLE:  - Presentation of points of general discussion and voting among the speakers of the European Thyroid Association-Cancer Research Network (ETA-CRN) meeting in Lisbon, 2009, entitled “European comments to ATA medullary thyroid cancer guidelines”.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Thyroid Res. 2013 Mar 14;6 Suppl 1:S11. doi: 10.1186/1756-6614-6-S1-S11. Epub 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1756-6614-6-S1-S11

AUTORES / AUTHORS:  - Jarzab B; Krol A; Hasse-Lazar K; Jurecka-Lubieniecka B

INSTITUCIÓN / INSTITUTION:  - Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeze Armii  Krajowej 15, 44-101 Gliwice, Poland. bjarzab@io.gliwice.pl.

RESUMEN / SUMMARY:  - The main subjects of discussion, held online within the ETA-CRN board invited 16  expert-panelists are shown. The ad hoc emerged ETA-CRN panel of experts (EPE) first congratulated Professor Kloos and the ATA Taskforce for the extensive work  on medullary thyroid cancer, and appreciated discussing the ATA guidelines during the ETA-CRN meeting. As it was not possible for all experts to visit the meeting, they enclosed their comments in the online ETA forum. The overall intention was to evaluate certain discrepancies between the ATA guidelines and were biased European clinical practice.All discussants were aware that the ATA guidelines had followed evidence based medicine rules; however, it was intended to reach an European consensus in this matter. The results of online voting among the EPE are shown.We received answers from nine experts. The particular ATA guidelines devoted to the management of MTC ranged in agreement in 0/9 to 4/9. This did not  reflect the general, good assessment of the guidelines, as of votes a set of questions.The strongest discrepancies were found in assessment of the usefulness  of pentagastrin (Peptavlon®) stimulated calcitonin secretion. The majority of the EPE (5/9) chose an option: “the increase of the basal Ct >100 ng/L means the  substantial risk of MTC. However, there should also have been a recommendation for the grey zone 10-100 ng/L, where stimulation with pentagastrin is useful. The cut-off to perform stimulation test at </= 15-20 ng/L and values >100 ng/L means  a significant suspicion of MTC”.Similarly, attention from the EPE was raised towards the surgical procedures in MTC, particularly the extent and indications for lymph node surgical intervention. Four questions were related to the indications to lymphadenectomy and extent of surgery. The equal number (4/8) of EPE agreed with the ATA R61 and half of the ETA-CRN panel of experts disagreed because the indications to lymphadenectomy (Lx) depended in their opinion on the  tumors detected by the Ct screening, in which prophylactic Lx might not be necessary.”Notwithstanding the evidence based guidelines, their final acceptation requires unrestricted discussion and consideration of differences in clinical practice and experience between countries”.



TÍTULO / TITLE:  - Appendiceal endometriosis and carcinoid presented as acute appendicitis in pregnancy: a rare case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Obstet Gynecol. 2013;2013:360459. doi: 10.1155/2013/360459. Epub 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/360459

AUTORES / AUTHORS:  - Dimitriadis PA; Makar RR; Kingston G; Farouk R

INSTITUCIÓN / INSTITUTION:  - General Surgery Department, Royal Berkshire Hospital, London Road, Reading RG1 5AN, UK.

RESUMEN / SUMMARY:  - A 22-year-old pregnant woman presented at the twenty-seventh week of gestation in the Emergency Department with acute abdominal pain and right iliac fossa tenderness. Urgent MRI was done and was suggestive of acute appendicitis. A laparoscopy was performed that confirmed an inflamed and purulent appendix that was removed. The technique used is described in detail. The histopathologic findings were those of acute appendicitis, carcinoid, and endometriosis of the appendix. We report the first case of this extremely rare triad presented in pregnancy.



TÍTULO / TITLE:  - Goblet cell carcinoid of appendix: A rare case with literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Case Rep. 2013;4(3):334-7. doi: 10.1016/j.ijscr.2013.01.007. Epub 2013 Jan 23.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2013.01.007

AUTORES / AUTHORS:  - Mitra B; Pal M; Paul B; Saha TN; Maiti A

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Midnapore Medical College & Hospital, Paschim Medinipur, West Bengal, India. Electronic address: bhaskarmitra12@gmail.com.

RESUMEN / SUMMARY:  - INTRODUCTION: The goblet cell carcinoid, a rare tumor of the appendix, is a separate entity from adenocarcinoma and carcinoid tumors. PRESENTATION OF CASE: We report a case of goblet cell carcinoid in our institute who presented with acute abdominal symptoms simulating acute appendicitis. DISCUSSION: Goblet cell carcinoid is a rare neoplasm with distinct histological and clinical features. The diagnosis is essentially made on histological grounds. Still the exact biological behavior of this tumor is uncertain. CONCLUSION: Considering the difficulty of clinical suspicion of this tumor, presenting as appendicitis and incidentally found during appendectomies, we review the goblet cell carcinoid of  the appendix using an illustrative case report.



TÍTULO / TITLE:  - Synchronous solid neuroendocrine breast carcinoma and abdominal lymphoma: A case  report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Feb;5(2):459-462. Epub 2012 Nov 23.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1044

AUTORES / AUTHORS:  - Alonso-Ruano M; Lopez-Bonet E; Huerta-Anaya MV; Vila-Camps E; Bernado L; Tuca-Rodriguez F; Suarez-Pumariega P; Menendez JA

INSTITUCIÓN / INSTITUTION:  - Departments of Gynecology, Dr Josep Trueta Hospital of Girona, Girona; Catalonia, España.

RESUMEN / SUMMARY:  - Neuroendocrine tumors (NETs) are frequently associated with second primary malignancies (SPMs). Earlier studies have demonstrated that NETs are highly associated with synchronous or metachronous gastrointestinal and genitourinary SPMs. We report, for the first time, a case of pure NE breast carcinoma (NEBC) exhibiting all of the World Health Organization (WHO)-categorized morphological and phenotypic NE features (i.e., round solid nests of spindle cells, plasmacytoid cells, large clear or mucinous signet-ring cells with a peripheral palisading tendency and immunohistochemical positivity for the NE markers synaptophysin and chromogranin in more than 50% of the tumor cell population) along with synchronous abdominal non-Hodgkin’s lymphoma. In the present study, we review the diagnosis, clinicopathological features and histogenetic profiling of  NEBC and discuss the literature relevant to the clinical and anatomopathological  management of this case. This previously unreported case of synchronous solid NEBC and abdominal lymphoma, together with earlier studies showing that primary symptoms are caused by SPMs in a significant subgroup of NET patients, strongly supports the notion that NETs should be cautiously considered to be index tumors. Therefore, risk-adapted clinicopathological follow-up with systematic investigation is strongly recommended.



TÍTULO / TITLE:  - Gastric carcinoid and obesity: association or coincidence? Report of two cases and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Gastrointest Med. 2013;2013:848075. doi: 10.1155/2013/848075. Epub 2013  Jan 15.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/848075

AUTORES / AUTHORS:  - Al-Harbi O; Shakir M; Al-Brahim N

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Farwaniya Hospital, 81004 Sabah Al-Naser, Kuwait.

RESUMEN / SUMMARY:  - Bariatric surgery is a prevalent procedure due to the high incidence of obesity and comorbidities. Upper gastrointestinal endoscopy is one of the procedures used to evaluate the patient before surgery. However, its role is questionable. The incidental findings during endoscopy are variable including inflammatory diseases, and ulcers, and epithelial and stromal tumors. Herein a report of two obese sisters with incidental gastric carcinoids was diagnosed in prebariatric surgery endoscopy. Case Summary. 35- and 41-year-old female patients presented with obesity and BMI of 102 and 46 kg/m(2), respectively. Both patients underwent upper gastrointestinal endoscopy as part of presurgical evaluation. Multiple polyps were indentified in both patients, and biopsy was taken. Histological examination revealed tumors that were formed by nests of epithelial cells. The cells have eosinophilic cytoplasm and monomorphic nuclei, typical morphology of neuroendocrine tumors. Conclusions. (1) Upper gastrointestinal endoscopy is an important procedure for prebariatric surgery evaluation. (2) Gastric carcinoid is a rare tumor with higher incidence among obese patients.



TÍTULO / TITLE:  - Paranasal sinus neuroendocrine carcinoma: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol Med. 2013;2013:728479. doi: 10.1155/2013/728479. Epub 2013 Feb 14.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/728479

AUTORES / AUTHORS:  - Sirsath NT; Babu KG; Das U; Premlatha CS

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore  560029, Karnataka, India.

RESUMEN / SUMMARY:  - Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. They can arise in almost every organ of the body  although they are most commonly found in the gastrointestinal tract and respiratory system. Nasal cavity and paranasal sinuses are a rare site for neuroendocrine carcinoma. In contrast to the other regions, neuroendocrine tumours of the sinuses have been reported to be recurrent and locally destructive. Very few cases of paranasal sinus neuroendocrine carcinoma have been reported till date. Difficulty in pathologic diagnosis and rarity of this malignancy have hindered the progress in understanding the clinical course and improving outcomes. We herein report a case of poorly differentiated neuroendocrine tumour of ethmoid and sphenoid sinus with invasion of orbit and intracranial extension. The patient had complete response at the end of chemoradiation and he was disease-free for 9 months duration after which he developed bone metastasis without regional recurrence.



TÍTULO / TITLE:  - Introduction to European comments on “Medullary Thyroid Cancer: management guidelines of the American Thyroid Association”.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Thyroid Res. 2013 Mar 14;6 Suppl 1:S1. doi: 10.1186/1756-6614-6-S1-S1. Epub 2013  Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1756-6614-6-S1-S1

AUTORES / AUTHORS:  - Jarzab B; Feldt-Rasmussen U

INSTITUCIÓN / INSTITUTION:  - Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeze Armii  Krajowej 15, 44-101 Gliwice, Poland. bjarzab@io.gliwice.pl.

RESUMEN / SUMMARY:  - Guest Editors of Thyroid Research supplement devoted to medullary thyroid cancer  present the history on how the discussion about “Medullary Thyroid Cancer: management guidelines of the American Thyroid Association” was initiated and subsequently widely commented before and during European Thyroid Association - Cancer Research Network Meeting in Lisbon. It is explained why it has been decided to publish the manuscripts within the supplement - to document voices from the discussion and popularize them.