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Connective and Soft Tissue Tumors.

February - March 2013


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TÍTULO / TITLE:  - Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cochrane Database Syst Rev. 2013 Feb 28;2:CD006812. doi: 10.1002/14651858.CD006812.pub3.

            ●● Enlace al texto completo (gratuito o de pago) 1002/14651858.CD006812.pub3

AUTORES / AUTHORS:  - Galaal K; van der Heijden E; Godfrey K; Naik R; Kucukmetin A; Bryant A; Das N; Lopes AD

INSTITUCIÓN / INSTITUTION:  - Gynaecological Oncology, Princess Alexandra Wing, Royal Cornwall Hospital, Truro, UK. Khadra.Galaal@rcht.cornwall.nhs.uk.

RESUMEN / SUMMARY:  - BACKGROUND: Uterine carcinosarcomas are uncommon with about 35% not confined to the uterus at diagnosis. The survival of women with advanced uterine carcinosarcoma is poor with a pattern of failure indicating greater likelihood of upper abdominal and distant metastatic recurrence. OBJECTIVES: To evaluate the effectiveness and safety of adjuvant radiotherapy and/or systemic chemotherapy in the management of uterine carcinosarcoma. SEARCH METHODS: We searched the Cochrane Gynaecological Cancer Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), 2012, Issue 10, MEDLINE and EMBASE up to November 2012. We also searched registers of clinical trials, abstracts of scientific meetings, reference lists of included studies and contacted experts in the field. SELECTION CRITERIA: Randomised controlled trials (RCTs) comparing adjuvant radiotherapy and/or chemotherapy in women with uterine carcinosarcoma. DATA COLLECTION AND ANALYSIS: Two review authors independently abstracted data and assessed risk of bias. Hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) and risk ratios (RRs) comparing adverse events in women who received radiotherapy and/or chemotherapy were pooled in random-effects meta-analyses. MAIN RESULTS: Three trials met the inclusion criteria and these randomised 579 women, of whom all were assessed at the end of the trials. Two trials assessing 373 participants with stage III to IV persistent or recurrent disease, found that women who received combination therapy had a significantly lower risk of death and disease progression than women who received single agent  ifosfamide, after adjustment for performance status (HR = 0.75, 95% confidence interval (CI): 0.60 to 0.94 and HR = 0.72, 95% CI: 0.58 to 0.90 for OS and PFS respectively). There was no statistically significant difference in all reported  adverse events, with the exception of nausea and vomiting, where significantly more women experienced these ailments in the combination therapy group than the Ifosamide group (RR = 3.53, 95% CI: 1.33 to 9.37).In one trial there was no statistically significant difference in the risk of death and disease progression in women who received whole body irradiation and chemotherapy, after adjustment for age and FIGO stage (HR = 0.71, 95% CI: 0.48 to 1.05 and HR = 0.79, 95% CI: 0.53 to 1.18 for OS and PFS respectively). There was no statistically significant difference in all reported adverse events, with the exception of haematological and neuropathy morbidities, where significantly less women experienced these morbidities in the whole body irradiation group than the chemotherapy group (RR=  0.02, 95% CI: 0.00 to 0.16) for haematological morbidity and all nine women in the trial experiencing neuropathy morbidity were in the chemotherapy group). AUTHORS’ CONCLUSIONS: In advanced stage metastatic uterine carcinosarcoma as well as recurrent disease adjuvant combination, chemotherapy with ifosfamide should be considered. Combination chemotherapy with ifosfamide and paclitaxel is associated with lower risk of death compared with ifosfamide alone. In addition, radiotherapy to the abdomen is not associated with improved survival.



TÍTULO / TITLE:  - Progestogens or progestogen-releasing intrauterine systems for uterine fibroids.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cochrane Database Syst Rev. 2013 Feb 28;2:CD008994. doi: 10.1002/14651858.CD008994.pub2.

            ●● Enlace al texto completo (gratuito o de pago) 1002/14651858.CD008994.pub2

AUTORES / AUTHORS:  - Sangkomkamhang US; Lumbiganon P; Laopaiboon M; Mol BW

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology, Khon Kaen Hospital, Khon Kaen, Thailand. swadpanich@hotmail.com

RESUMEN / SUMMARY:  - BACKGROUND: Uterine fibroids are the most common premenopausal benign uterine tumours. Fibroids can cause symptoms including heavy menstrual bleeding, pelvic pressure and pain. Progestogens can be administered by various routes. Intramuscular injection of depot medroxyprogesterone acetate (DMPA) has dual actions (stimulatory or inhibitory) on fibroid cell growth. Progestogen-releasing intrauterine systems (IUS) decrease menstrual blood loss associated with fibroids by inducing endometrial atrophy and reduction of uterine fibroid size. Currently, their effectiveness for the treatment of uterine fibroids has not been evaluated. OBJECTIVES: To determine the effectiveness of progestogens or progestogen-releasing intrauterine systems in treating premenopausal women with uterine fibroids. SEARCH METHODS: We searched the Menstrual Disorders and Subfertility Group Specialised Register (inception to 17 August 2012), CENTRAL (inception to 17 August 2012) and Database of Abstracts of Reviews of Effects (DARE) in The Cochrane Library, MEDLINE (inception to 17 August 2012), Ovid EMBASE (1 January 2010 to 17 August 2012), Ovid PsycINFO (inception to 17 August  2012), CINAHL database, and trials registers for ongoing and registered trials. SELECTION CRITERIA: All identified published or unpublished randomised controlled trials (RCTs) assessing the effect of progestogens or progestogen-releasing intrauterine systems in treating premenopausal women with uterine fibroids. DATA  COLLECTION AND ANALYSIS: We assessed all potentially eligible studies identified  as a result of the search strategy. Two review authors extracted data from each included study using an agreed form and assessed the risk of bias. We resolved discrepancies through discussion. MAIN RESULTS: This review included three studies. However, data for progestogen-releasing intrauterine systems were available from only one study that compared 29 women with a levonorgestrel (LNG)-IUS versus 29 women with a combined oral contraceptive (COC) for treating uterine fibroids. There was a significant reduction of menstrual blood loss (MBL) in women receiving the LNG-IUS compared to the COC using the alkaline hematin test (mean difference (MD) 77.5%, 95% CI 71.3% to 83.67%, 58 women) and a pictorial assessment chart (PBAC) (MD 34.5%, 95% CI 14.9% to 54.1%, 58 women). The reduction in uterine fibroid size was significantly greater in the leuprorelin group at 16 weeks compared to the progestogen lynestrenol group (MD -15.93 mm, 95% CI -18.02 to -13.84 mm, 46 women). There was no RCT evaluating the effect of DMPA on uterine fibroids. AUTHORS’ CONCLUSIONS: Progestogen-releasing intrauterine systems appear to reduce menstrual blood loss in premenopausal women with uterine fibroids. Oral progestogens did not reduce fibroid size or fibroid-  related symptoms. However, there was a methodological limitation and the one included study with data had a small sample size. This evidence is insufficient to support the use of progestogens or progestogen-releasing intrauterine systems  in treating premenopausal women with uterine fibroids.



TÍTULO / TITLE:  - Adherence to treatment guidelines for primary sarcomas affects patient survival:  a side study of the European CONnective TIssue CAncer NETwork (CONTICANET).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Oncol. 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 1093/annonc/mdt031

AUTORES / AUTHORS:  - Rossi CR; Vecchiato A; Mastrangelo G; Montesco MC; Russano F; Mocellin S; Pasquali S; Scarzello G; Basso U; Frasson A; Pilati P; Nitti D; Lurkin A; Ray-Coquard I

INSTITUCIÓN / INSTITUTION:  - Melanoma and Sarcomas Unit, Veneto Institute of Oncology-IRCCS, Padova.

RESUMEN / SUMMARY:  - BackgroundThe impact of adherence to clinical practice guidelines (CPGs) for loco-regional treatment (i.e. surgery and radiotherapy) and chemotherapy on local disease control and survival in sarcoma patients was investigated in a European study conducted in an Italian region (Veneto).Patients and methodsThe completeness of the adherence to the Italian CPGs for sarcomas treatment was assessed by comparing the patient’s charts and the CPGs. Propensity score-adjusted multivariate survival analysis was used to assess the impact of CPGs adherence on patient clinical outcomes.ResultsA total of 151 patients were included. Adherence to CPGs for loco-regional therapy and chemotherapy was observed in 106 out of 147 (70.2%) and 129 out of 139 (85.4%) patients, respectively. Non-adherence to CPGs for loco-regional treatment was independently associated with AJCC stage III disease [odds ratio (OR) 1.77, P = 0.011] and tumor-positive excision margin (OR 3.55, P = 0.003). Patients not treated according to the CPGs were at a higher risk of local recurrence [hazard ratio (HR) 5.4, P < 0.001] and had a shorter sarcoma-specific survival (HR 4.05, P < 0.001), independently of tumor stage.ConclusionsIncomplete adherence to CPGs for  loco-regional treatment of sarcomas was associated with worse prognosis in patients with non-metastatic tumors.




TÍTULO / TITLE:  - Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cochrane Database Syst Rev. 2013 Feb 28;2:CD006246. doi: 10.1002/14651858.CD006246.pub2.

            ●● Enlace al texto completo (gratuito o de pago) 1002/14651858.CD006246.pub2

AUTORES / AUTHORS:  - Shylasree TS; Bryant A; Athavale R

INSTITUCIÓN / INSTITUTION:  - GynaecologicalOncologyDivision,Department of SurgicalOncology,TataMemorialCentre,Mumbai, India. shyla_sree@hotmail.com.

RESUMEN / SUMMARY:  - BACKGROUND: Ovarian carcinosarcoma, also known as malignant mixed Mullerian tumour, is a rare malignant gynaecological tumour constituting about 1% or less of all ovarian cancers. In over 80% of cases, there is extra-ovarian intra-abdominal spread at diagnosis. The primary treatment has traditionally been surgical cytoreduction followed by radiotherapy and chemotherapy or chemotherapy  alone. Regimes have included cisplatin alone; a combination of doxorubicin, ifosfamide, dacarbazine, cyclophosphamide, taxol; and various other combinations. The effectiveness of these various regimens appears to be mixed. Therefore, there is a need to clarify if there is an optimum neoadjuvant or adjuvant therapy after surgical cytoreduction for this rare tumour. Also, it is important to address quality of life (QoL) issues related to treatment, particularly toxicity, as the  overall prognosis appears to be poor. OBJECTIVES: To assess the effectiveness and safety of various adjuvant and neoadjuvant chemotherapy and radiotherapy options  or chemotherapy alone in combination with surgery in the management of ovarian carcinosarcoma. SEARCH METHODS: We searched the Cochrane Gynaecological Cancer Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE up to February 2012. We also searched registers of  clinical trials, abstracts of scientific meetings, reference lists of review articles and contacted experts in the field. SELECTION CRITERIA: We searched for  randomised controlled trials (RCTs) that compared neoadjuvant or adjuvant chemotherapy and radiotherapy, or chemotherapy alone, in women with ovarian carcinosarcoma (malignant mixed Mullerian sarcoma of the ovary). We also reviewed non-randomised studies (NRS) for discussion in the absence of RCTs. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed whether potentially relevant studies met the inclusion criteria. No trials were found and therefore no data were analysed. MAIN RESULTS: The search strategy identified 297 unique references of which all were excluded. AUTHORS’ CONCLUSIONS: We found no evidence to inform decisions about neoadjuvant and adjuvant chemotherapy and radiotherapy regimens, or chemotherapy alone, for women with ovarian carcinosarcoma. Ideally, an RCT that is multicentre or multinational, or well designed non-randomised studies that use multivariate analysis to adjust for baseline imbalances, are needed to compare treatment modalities and improve current knowledge. Further research in genetic and molecular signalling pathways  might improve understanding of this tumour subtype.



TÍTULO / TITLE:  - Adult Rhabdomyosarcoma Survival Improved With Treatment on Multimodality Protocols.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Radiat Oncol Biol Phys. 2013 Feb 12. pii: S0360-3016(12)03912-0. doi: 10.1016/j.ijrobp.2012.12.016.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijrobp.2012.12.016

AUTORES / AUTHORS:  - Gerber NK; Wexler LH; Singer S; Alektiar KM; Keohan ML; Shi W; Zhang Z; Wolden S

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York.

RESUMEN / SUMMARY:  - PURPOSE: Rhabdomyosarcoma (RMS) is a pediatric sarcoma rarely occurring in adults. For unknown reasons, adults with RMS have worse outcomes than do children. METHODS AND MATERIALS: We analyzed data from all patients who presented to Memorial Sloan-Kettering Cancer Center between 1990 and 2011 with RMS diagnosed at age 16 or older. One hundred forty-eight patients met the study criteria. Ten were excluded for lack of adequate data. RESULTS: The median age was 28 years. The histologic diagnoses were as follows: embryonal 54%, alveolar 33%, pleomorphic 12%, and not otherwise specified 2%. The tumor site was unfavorable in 67% of patients. Thirty-three patients (24%) were at low risk, 61  (44%) at intermediate risk, and 44 (32%) at high risk. Forty-six percent were treated on or according to a prospective RMS protocol. The 5-year rate of overall survival (OS) was 45% for patients with nonmetastatic disease. The failure rates  at 5 years for patients with nonmetastatic disease were 34% for local failure and 42% for distant failure. Among patients with nonmetastatic disease (n=94), significant factors associated with OS were histologic diagnosis, site, risk group, age, and protocol treatment. On multivariate analysis, risk group and protocol treatment were significant after adjustment for age. The 5-year OS was 54% for protocol patients versus 36% for nonprotocol patients. CONCLUSIONS: Survival in adult patients with nonmetastatic disease was significantly improved  for those treated on RMS protocols, most of which are now open to adults.




TÍTULO / TITLE:  - Lack of uniformity in the clinical assessment of children with lipomyelomeningocele: a review of the literature and recommendations for the future.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Childs Nerv Syst. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00381-013-2063-2

AUTORES / AUTHORS:  - May L; Hayward R; Chakraborty A; Franck L; Manzotti G; Wray J; Thompson D

INSTITUCIÓN / INSTITUTION:  - Department of Paediatric Neurosurgery, Great Ormond Street Hospital for Children, NHS Foundation Trust, Great Ormond Street, London, UK, Lindy.May@gosh.nhs.uk.

RESUMEN / SUMMARY:  - OBJECTIVE: An objective clinical assessment tool whose accuracy and reproducibility can be validated is essential for the initial evaluation, selection for surgery and surveillance of children with lipomyelomeningocele (LMMC). The aim of this study was to analyse the large number of such tools presently in use and recommend an alternative that could lead to greater uniformity between different series and greater consistency in the assessment of  individual patients. METHODS: A systematic review of the literature between January 1980 and December 2010 was undertaken and details of how the children in  each series were assessed and the degree to which age was taken into account recorded. RESULTS: Thirty-six different assessment tools were used in 40 different publications. None was validated in all aspects. Objective measures were used most in urological assessments but rarely in other domains. Age-specific assessments were used in only 10 % of publications. CONCLUSION: This study confirmed that the assessment tools for evaluation of children with LMMC are inconsistent, often vague and poorly validated. This compromises the ability  of clinicians who care for them to compare studies across centres for both treated and untreated children. We have sought to highlight those criteria which  are relevant, measurable and reproducible and which might be combined into an easily applied assessment.




TÍTULO / TITLE:  - Novel hormone treatment of benign metastasizing leiomyoma: an analysis of five cases and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Fertil Steril. 2013 Mar 2. pii: S0015-0282(13)00253-7. doi: 10.1016/j.fertnstert.2013.01.147.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.fertnstert.2013.01.147

AUTORES / AUTHORS:  - Lewis EI; Chason RJ; Decherney AH; Armstrong A; Elkas J; Venkatesan AM

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, UCLA Medical Center, Los Angeles, California. Electronic address: elewis@mednet.ucla.edu.

RESUMEN / SUMMARY:  - OBJECTIVE: To evaluate novel hormonal therapies in patients with unresectable benign metastasizing leiomyoma (BML) disease. DESIGN: Case series. SETTING: National Institutes of Health (NIH). PATIENT(S): Five subjects with the diagnosis of BML based on imaging and/or histopathologic diagnosis. INTERVENTION(S): Four patients were treated with single or combination therapy of leuprolide acetate and/or an aromatase inhibitor. One patient was treated with an antiprogestin (CDB-2914). MAIN OUTCOME MEASURE(S): Response to therapy was measured by tumor burden on cross-sectional imaging employing RECIST (Response Evaluation Criteria  in Solid Tumors) 1.1 guidelines. RESULT(S): Four patients treated with single or  combination therapy of leuprolide acetate and/or an aromatase inhibitor demonstrated stable disease with reduction in tumor burden. The fifth patient treated with antiprogestin (CDB-2914) had degeneration of her tumor, progression  of its size, and an improvement in symptoms. CONCLUSION(S): Hormone treatment with GnRH agonist and/or aromatase inhibition may be a therapeutic option to reduce tumor burden in unresectable BML disease or for those patients who wish to avoid surgical intervention. RECIST 1.1 guidelines, while traditionally used to evaluate tumor response to cancer therapeutics, may be useful in evaluating BML tumor burden response to hormone therapy.




TÍTULO / TITLE:  - Comment to the paper by L. May: Lack of uniformity in the clinical assessment of  children with lipomyelomeningocele. A review of the literature and recommendations for the future.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Childs Nerv Syst. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00381-013-2068-x


INSTITUCIÓN / INSTITUTION:  - Paediatric Neurosurgery, Catholic University Medical School, A. Gemelli Hospital, L. go A. Gemelli 8, 00168, Rome, Italy, cdirocco@rm.unicatt.it.




TÍTULO / TITLE:  - Harmonic scalpel surgical treatment of the tongue angioleomyoma—case report and  review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Coll Antropol. 2012 Nov;36 Suppl 2:167-70.

AUTORES / AUTHORS:  - Danic D; Hadzibegovic AD; Stojadinovic T; Damjanovic D; Gudelj A; Mahovne I

INSTITUCIÓN / INSTITUTION:  - Josip Juraj Strossmayer University, Osijek School of Medicine, Dr. Josip Bencevic, General Hospital, Department of Otorhinolaryngology and Head and Neck Surgery, Slavonski Brod, Croatia. davorin.djanic@sb.t-com.hr

RESUMEN / SUMMARY:  - Angioleiomyoma is benign soft tissue tumor composed of smooth muscle cells and vascular endothelium, characterized with slow growth, unspecific symptoms and rare malignant transformation. It is very rare in the head and neck region and complete surgical excision is the gold standard for diagnosis and treatment. We present a very rare case of angoleomyoma of the tounge base treated with partial  glosectomy with harmonic scalpel which shortened surgical procedure, reduced bleeding and postoperative complications.




TÍTULO / TITLE:  - Cardiac angiosarcoma in a pregnant woman: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Cardiol. 2012 Dec;67(6):727-31.

AUTORES / AUTHORS:  - Saraiva F; Antunes M; Providencia LA

INSTITUCIÓN / INSTITUTION:  - Department of Cardiology, Coimbra Hospital and Medical School, Coimbra, Portugal. saraiva.fatima@gmail.com

RESUMEN / SUMMARY:  - Cardiac angiosarcomas, although very rare, are the most common primary malignant  tumours. They are characterized by no specific clinical findings, rapid growth with frequent metastasis at the time of diagnosis and a reduced response to treatment. We describe the case of a 34-year-old pregnant woman who began to complain of dyspnoea and palpitations at 32 weeks of gestation. The echocardiogram showed a mass in the right atrial cavity and the CT scan showed extensive local invasion and hepatic metastasis. After 4 weeks, because of progressive heart failure due to obstruction of the tricuspid valve by the mass,  the patient was submitted to an urgent caesarean section followed, two days later, by palliative cardiac surgery in order to alleviate the symptoms. Adjuvant chemotherapy was performed.




TÍTULO / TITLE:  - Primary cardiac myxofibrosarcoma: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tumori. 2012 Nov;98(6):165e-8e. doi: 10.1700/1217.13514.

            ●● Enlace al texto completo (gratuito o de pago) 1700/1217.13514

AUTORES / AUTHORS:  - Wang JG; Li YJ; Liu H; Zhao P

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, Qingdao, Shandong Province, China. qdwangjigang@hotmail.com

RESUMEN / SUMMARY:  - AIMS AND BACKGROUND: Primary myxofibrosarcoma of the heart is a rare malignancy.  To the best of our knowledge, no more than 17 cases have been reported since 1963. METHODS AND STUDY DESIGN: We report the case of a 42-year-old man who presented with dyspnea and palpitation of one month’s duration. Echocardiography  and enhanced computed tomography revealed a large tumor in the left atrium. RESULTS: The patient underwent palliative excision of the tumor and histopathological analysis revealed it to be a low-grade myxofibrosarcoma. The patient developed a bone metastasis two years later and is still alive 26 months  after the cardiac surgery. CONCLUSIONS: Primary cardiac myxofibrosarcoma involves predominantly the left atrium and the most common symptom induced by the tumor is dyspnea. Disease outcome is often disappointing despite aggressive postoperative  radiotherapy and chemotherapy.




TÍTULO / TITLE:  - Ewing sarcoma of the kidney: case series and literature review of an often overlooked entity in the diagnosis of primary renal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Urology. 2013 Feb;81(2):347-53. doi: 10.1016/j.urology.2012.10.016.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.urology.2012.10.016

AUTORES / AUTHORS:  - Rowe RG; Thomas DG; Schuetze SM; Hafez KS; Lawlor ER; Chugh R

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-5848, USA.

RESUMEN / SUMMARY:  - OBJECTIVE: To evaluate our own experience with primary Ewing sarcoma family tumors (ESFTs) of the kidney and to review cases of this in published reports. MATERIALS AND METHODS: Institutional cases of renal ESFT were identified in our pathology database. The retrieved records were reviewed for relevant data. Published cases of renal ESFTs were identified from the National Library of Medicine Medline database and restricted to English language studies. The factors associated with initial surgical management (diagnostic biopsy vs surgical resection) were analyzed using chi-square analysis. RESULTS: We diagnosed and treated 10 cases of renal ESFT from 2002 to 2011 and identified an additional 97  published cases describing this tumor. A review of these 107 cases revealed that  renal ESFTs more often presented with distant metastases than did ESFTs of the bone or soft tissue. Moreover, patients rarely received preoperative (neoadjuvant) chemotherapy, the current standard of care for ESFT, often because  of early total tumor resection without diagnostic biopsy. Younger patients and patients with distant metastases were more likely to undergo diagnostic biopsy as initial management (P <.0001), allowing for use of neoadjuvant chemotherapy. CONCLUSION: ESFTs of the kidney should be considered in the differential diagnosis of renal masses. Preoperative biopsy should be considered to identify these tumors to allow for delivery of neoadjuvant chemotherapy.




TÍTULO / TITLE:  - Rhabdomyosarcoma in adrenal region of a child with hypertension and fever: A case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Surg. 2013 Mar;48(3):e5-8. doi: 10.1016/j.jpedsurg.2013.01.018.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpedsurg.2013.01.018

AUTORES / AUTHORS:  - Yi X; Long X; Xiao D; Zai H; Li Y

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.

RESUMEN / SUMMARY:  - Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children but rarely involves the adrenal. We describe a case of alveolar rhabdomyosarcoma (ARMS) of the right adrenal in a 5-year-old boy with a characteristic history of  hypertension and recurrent fever. On surveillance imaging, a right adrenal mass was incidentally detected, and a right adrenalectomy was subsequently performed.  After the surgery, the fever disappeared simultaneously, and the blood pressure gradually returned to normal level. This is the first reported case in children.




TÍTULO / TITLE:  - Osteosarcoma tumor thrombus: a case report with a review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tex Heart Inst J. 2013;40(1):75-8.

AUTORES / AUTHORS:  - Navalkele P; Jones SM; Jones JK; Salazar JD; Toy PC; Iyer RV; Herrington B

INSTITUCIÓN / INSTITUTION:  - Department of Pediatrics (Drs. Herrington, Iyer, S. Jones, and Navalkele); Department of Pathology (Dr. J. Jones); Division of Pediatric & Congenital Heart  Surgery; Department of Surgery (Dr. Salazar); and Division of Pediatric Hematology-Oncology (Drs. Herrington and Iyer), University of Mississippi Medical Center, Jackson, Mississippi 39216; and Department of Orthopaedics (Dr. Toy), Campbell Clinic-University of Tennessee, Memphis, Tennessee 38104.

RESUMEN / SUMMARY:  - Tumor thrombus arising from osteosarcoma is rare. We report the case of a 20-year-old man with proximal humerus osteosarcoma, accompanied by an extensive intravascular tumor thrombus extending into the heart. Our review of the literature found 14 previous reports on osteosarcoma with tumor thrombus. The combination of positron emission tomography and computed tomography is very useful in differentiating tumor thrombus from vascular thrombus, thereby avoiding unnecessary anticoagulation therapy. This same imaging combination can also be used to evaluate the response to treatment. Surgical resection of the tumor thrombus is highly recommended. The effect of tumor thrombus on survival is still unknown.




TÍTULO / TITLE:  - Alveolar rhabdomyosarcoma arising in a giant congenital melanocytic nevus in an adult - case report with review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Dermatol. 2013 Mar 3. doi: 10.1111/j.1365-4632.2011.05448.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1365-4632.2011.05448.x

AUTORES / AUTHORS:  - Chikhalkar S; Gutte R; Holmukhe S; Khopkar U; Desai S; Gupta S

INSTITUCIÓN / INSTITUTION:  - From the Department of Dermatology, Seth G.S. Medical College and KEM Hospital Department of Pathology, Tata Memorial Hospital Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India.




TÍTULO / TITLE:  - Ewing sarcoma of the thyroid: Report of 2 cases and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Head Neck. 2013 Mar 18. doi: 10.1002/hed.23240.

            ●● Enlace al texto completo (gratuito o de pago) 1002/hed.23240

AUTORES / AUTHORS:  - Chan JM; Bilodeau E; Celin S; Nikiforov Y; Johnson JT

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania. chanjm@upmc.edu.

RESUMEN / SUMMARY:  - BACKGROUND: Neuroendocrine tumors of the thyroid encompass a wide differential diagnosis. The most common is medullary thyroid carcinoma. One must consider other possibilities when a neuroendocrine thyroid tumor is calcitonin negative. We report 2 cases of Ewing sarcoma of the thyroid and discuss the differential diagnosis and workup of a calcitonin-negative neuroendocrine tumor of the thyroid. METHODS/RESULTS: This is a retrospective review of 2 patients diagnosed  with Ewing sarcoma of the thyroid and a review of the literature. CONCLUSIONS: Ewing sarcoma of the thyroid is an exceedingly rare diagnosis, but should be included in the differential diagnosis for a thyroidal neuroendocrine lesion (especially in the absence of calcitonin). The use and interpretation of immunohistochemistry (IHC) and fluorescent in situ hybridization are essential in making the correct diagnosis. © 2013 Wiley Periodicals, Inc. Head Neck, 2013.




TÍTULO / TITLE:  - Kaposi sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Pathol Lab Med. 2013 Feb;137(2):289-94. doi: 10.5858/arpa.2012-0101-RS.

            ●● Enlace al texto completo (gratuito o de pago) 5858/arpa.2012-0101-RS

AUTORES / AUTHORS:  - Radu O; Pantanowitz L

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15232, USA.

RESUMEN / SUMMARY:  - Kaposi sarcoma (KS) is a low-grade vascular tumor associated with Kaposi sarcoma  herpesvirus/human herpesvirus 8 (KSHV/HHV8) infection. Kaposi sarcoma lesions predominantly present at mucocutaneous sites, but may involve all organs and anatomic locations. Recognized epidemiologic-clinical forms of KS include classic, African (endemic), AIDS-associated (epidemic), and iatrogenic KS. New clinical manifestations have been described, such as antiretroviral therapy-related KS regression or flares. Kaposi sarcoma lesions evolve from early (patch stage) macules into plaques (plaque stage) that grow into larger nodules (tumor stage). Newer histologic variants include anaplastic, hyperkeratotic, lymphangioma-like, bullous, telangiectatic, ecchymotic, keloidal, pyogenic granuloma-like, micronodular, intravascular, glomeruloid and pigmented KS, as well as KS with sarcoidlike granulomas and KS with myoid nodules. Latency-associated nuclear antigen (HHV8) is the most specific immunohistochemical marker available to help distinguish KS from its mimics. Since KS remains one of the most common AIDS-defining malignancies, it is important that pathologists be able to recognize KS and its contemporary manifestations.




TÍTULO / TITLE:  - Dermatofibrosarcoma protuberans on the right neck with superior vena cava syndrome: Case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Oral Maxillofac Surg. 2013 Mar 24. pii: S0901-5027(13)00098-2. doi: 10.1016/j.ijom.2013.02.014.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijom.2013.02.014

AUTORES / AUTHORS:  - Ong HS; Ji T; Wang LZ; Yu ZW; Zhang CP

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology,  Shanghai, PR China.

RESUMEN / SUMMARY:  - Dermatofibrosarcoma protuberans (DFSP) is an uncommon dermal soft tissue tumour of intermediate malignancy. A 44-year-old man presented to the hospital with a large lesion on the right upper chest and neck. Despite eight previous surgical excisions, the tumour had continued to recur. Contrast-enhanced computed tomography showed recurrence of the tumour, associated with superior vena cava (SVC) syndrome. He declined radical surgical resection of the recurrent tumour, which may have required right upper limb amputation. Targeted therapy with sunitinib malate was therefore introduced. This case demonstrates the recurrent nature of DFSP and the association of this lesion on the upper chest/neck with SVC syndrome. Primary wide radical resection is essential for better local control and to avoid the development of SVC syndrome.




TÍTULO / TITLE:  - Multiple metastatic leiomyosarcoma of the pancreas: a first case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Intern Med. 2013;52(5):561-6. Epub 2013 Mar 1.

AUTORES / AUTHORS:  - Ogura T; Masuda D; Kurisu Y; Miyamoto Y; Hayashi M; Imoto A; Takii M; Takeuchi T; Inoue T; Tokioka S; Uchiyama K; Umegaki E; Higuchi K

INSTITUCIÓN / INSTITUTION:  - The 2nd Department of Internal Medicine, Osaka Medical College, Japan.

RESUMEN / SUMMARY:  - A 60-year-old woman was referred to our hospital with swelling of the right leg.  After surgery, leiomyosarcoma of the right leg was diagnosed. Computed tomography showed two hypovascular masses in the pancreatic body and tail that were heterogeneously enhanced compared with the pancreatic parenchyma. On endoscopic ultrasonography, the tumors in the pancreatic body and tail both exhibited regular margins and were visualized as well-circumscribed masses with uneven interiors. Distal pancreatectomy was performed under a presumptive diagnosis of metastatic pancreatic leiomyosarcoma diagnosed based on the findings of EUS-FNA.  On laparotomy, peritoneal washing cytology yielded negative results, and no dissemination was observed. Ultimately, metastatic pancreatic leiomyosarcoma was  histologically diagnosed.




TÍTULO / TITLE:  - Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - In Vivo. 2013 Mar-Apr;27(2):211-4.

AUTORES / AUTHORS:  - Perry AM; Nelson M; Sanger WG; Bridge JA; Greiner TC

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, University of Manitoba, Health Sciences Centre, Winnipeg, MB, Canada.

RESUMEN / SUMMARY:  - BACKGROUND: The identification of chromosomal abnormalities in many hematopoietic and mesenchymal neoplasms has contributed significantly to classification systems. Follicular dendritic cell (FDC) sarcoma is an intermediate-grade malignancy with morphological and immunophenotypic features of follicular dendritic cells. Available data on genetic changes in this neoplasm are limited,  with only isolated case reports of cytogenetic abnormalities. Case Report: We reviewed histological, immunophenotypic and cytogenetic findings in two cases of  FDC sarcoma. The two cases of FDC sarcoma, were observed in female patients, one  was nodal and one extranodal and they exhibited relatively complex karyotypes, characterized by structural abnormalities and loss of multiple chromosomes. One patient had several disease recurrences. At the last follow-up both patients were alive with no residual disease. CONCLUSION: The cytogenetic findings in these two cases, coupled with the few previously described abnormal karyotypes, suggest that FDC sarcoma is cytogenetically diverse.




TÍTULO / TITLE:  - Intraosseous hibernoma: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Skeletal Radiol. 2013 Mar 10.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00256-013-1593-8

AUTORES / AUTHORS:  - Botchu R; Puls F; Hock YL; Davies AM; Wafa H; Grimer RJ; Brocker V; James S

INSTITUCIÓN / INSTITUTION:  - Department of Musculoskeletal Radiology, The Royal Orthopedic Hospital, Birmingham, UK, drrajeshb@gmail.com.




TÍTULO / TITLE:  - Dumbbell ganglioneuroma mimicking lumbar neurofibroma: A case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Neurosurg. 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 3109/02688697.2013.771142

AUTORES / AUTHORS:  - Sobowale O; Ibrahim I; du Plessis D; Herwadkar A; Tzerakis N

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Greater Manchester Neurosciences Centre, Salford Royal Hospital , Salford, Greater Manchester , UK.

RESUMEN / SUMMARY:  - Spinal ganglioneuromas may grow in a dumbbell fashion. We report the first case of an intradural, extramedullary ganglioneuroma in the lumbar spine and review the pertinent literature. Although rare, we propose that ganglioneuroma be considered a differential diagnosis in patients presenting with a large mass occupying both intraspinal and extraspinal compartments.




TÍTULO / TITLE:  - Aggressive osteoblastoma of the temporal bone: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Mar;37(2):386-9. doi: 10.1016/j.clinimag.2012.05.017. Epub 2012 Jul 2.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.05.017


INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Affiliated Changshu Hospital of Soochow University, 1 Shuyuan Road, Changshu, Jiangsu 215500, China. Electronic address: luzhihua79@yahoo.com.cn.

RESUMEN / SUMMARY:  - Osteoblastoma can take place in any part of the skeleton. Its occurrence in the calvarium is extremely rare. The aggressive form of osteoblastoma is a rare variant. To our knowledge, this is the second case of aggressive osteoblastoma arising in the temporal bone. We report an 18-year-old patient with aggressive osteoblastoma involving the left temporal bone. Computed tomography of temporal bone showed an osteolytic lesion with granular mineralization and mottled ossified density. Permanent histopathologic sections and immunohistochemical stains revealed an aggressive osteoblastoma.




TÍTULO / TITLE:  - A modified protocol with vincristine, topotecan, and cyclophosphamide for recurrent/progressive ewing sarcoma family tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Hematol Oncol. 2013 Apr;30(3):170-7. doi: 10.3109/08880018.2013.767868.

            ●● Enlace al texto completo (gratuito o de pago) 3109/08880018.2013.767868

AUTORES / AUTHORS:  - Kebudi R; Cakir FB; Gorgun O; Agaoglu FY; Darendeliler E

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Hematology-Oncology, Cerrahpasa Medical Faculty, Istanbul University , Istanbul , Turkey.

RESUMEN / SUMMARY:  - Purpose: Topotecan has recently been used in the treatment of pediatric cancer. We evaluated our experience with the modified combination of vincristine, topotecan, and cyclophosphamide (VTC) given in 3 days, in children with recurrent Ewing sarcoma. Method: Children received vincristine (1.5 mg/m(2)/1st day), cyclophosphamide (600 mg/m(2)/day x 2 days) + mesna, and topotecan (1 mg/m(2)/day x 3 days) every 21 days. Result: A total of 118 courses of VTC were given to 13 patients. One patient received VTC both at first and at second relapse. Thus, 14  relapse episodes in 13 patients were evaluated. After three courses of VTC chemotherapy (CT), two achieved complete response (CR), five achieved partial response, thus an objective response was attained in 7/14 (50%) episodes. Two patients had stable disease and two patients progressed. In three episodes, CR was achieved by surgery before CT. One of them had a second relapse and attained  CR with VTC. Median time from diagnosis to relapse was 23 months (5-45 months). Site of relapse was local in four patients, and metastatic in 10 episodes of nine patients. Seven patients are alive, three with no evidence of disease and four alive with disease; six have died of disease. Local treatment was used in 11 episodes. The toxicity of the VTC combination was limited mainly to the hematopoietic system. Conclusion: In conclusion, the modified VTC protocol in 3 days every 3 weeks seems to be effective and tolerable in children and adolescents with recurrent/progressive Ewing sarcoma.




TÍTULO / TITLE:  - Cardiac papillary fibroelastoma: Retrospective clinicopathologic study of 17 tumors with resection at a single institution and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Res Pract. 2013 Feb 27. pii: S0344-0338(13)00022-8. doi: 10.1016/j.prp.2013.02.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.prp.2013.02.001

AUTORES / AUTHORS:  - Val-Bernal JF; Mayorga M; Garijo MF; Val D; Nistal JF

INSTITUCIÓN / INSTITUTION:  - Anatomical Pathology Department, Marques de Valdecilla University Hospital, Medical Faculty, University of Cantabria and IFIMAV, Santander, España. Electronic address: apavbj@humv.es.

RESUMEN / SUMMARY:  - Cardiac papillary fibroelastomas (PFEs), which are mainly found in the valves, are rare benign tumors that can cause embolism. Single-center surgical experience in the treatment of this tumor is uncommon. All patients surgically treated for this neoplasm at our institution from January 1995 to October 2012 (15 patients with 17 lesions) were queried for clinical and pathologic characteristics, and the literature was reviewed. The mean age of detection was 55.8+/-11.48 years. Twenty percent of the patients were male. The tumor was an incidental finding in  60%. Symptoms directly related to PFEs occurred in 40% of patients. The most common clinical presentation in symptomatic cases was embolism (40%), mostly transient ischemic attack or stroke. Cardiac valves were predominantly involved (76.5%); the most commonly valve affected was the aortic valve (29.4%), followed  by the mitral valve (17.6%). Concurrent valvular disease was observed in 41.7% of patients. The mean size of tumors was 11.4+/-7.9mm (range 2-25mm). In 86.7% of the patients, the tumor was solitary. The mitral valve was the most common origin of tumor systemic embolism. Fronds core could be the end stage of hypermature elastic fibers, which grows in apposition to young fibers. Simple surgical excision or valvular reconstruction was accomplished in most patients (58.3%). PFE is usually small, appears singly, and can cause potentially serious complications. Symptomatic and left side tumors should undergo surgical excision  with valve-spare surgery when possible. Surgical removal of PFE is safe, efficacious, and definitive.




TÍTULO / TITLE:  - Insulin-like growth factor 1 receptor as a therapeutic target in ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2013;2013:450478. doi: 10.1155/2013/450478. Epub 2013 Jan 28.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/450478

AUTORES / AUTHORS:  - O’Neill A; Shah N; Zitomersky N; Ladanyi M; Shukla N; Uren A; Loeb D; Toretsky J

INSTITUCIÓN / INSTITUTION:  - Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

RESUMEN / SUMMARY:  - The insulin-like growth factor 1 receptor (IGF-1R) has been considered an important therapeutic target in Ewing sarcoma (ES), generating a need to identify the subset of patients most likely to respond to IGF-1R inhibitors. We assessed IGF-1R expression in ES cell lines and patient tumors to understand the variable  clinical responses to anti-IGF-1R therapy. Using ligand-binding displacement, we  measured between 13,000 and 40,000 receptors per cell in ES cell lines. We used ELISA to quantify IGF-1R in patient tumors, which expressed 4.8% +/- 3.7 to 20.0% +/- 0.2 of the levels in a positive control cell line overexpressing IGF-1R. Flow cytometry showed markedly reduced IGF-1R expression in ES cell lines compared to  a standard positive control cell line. The IGF1R gene was sequenced in 47 ES tumor samples and 8 ES cell lines; only one tumor sample showed a nonsynonymous mutation, R1353H, in a region with low functional impact. Finally, we assessed IGF-1R pathway activity in the ES stem cell (ESSC) population, to characterize its potential for resistance to anti-IGF-1R therapy, using Luminex technology. We found no significant differences in IGF-1R pathway activity between ESSCs and the total cell population. Overall, our findings suggest that IGF-1R as a therapeutic target in this sarcoma may require reevaluation.




TÍTULO / TITLE:Liposarkommetastase des Herzens : Fallserie und kurze Literaturubersicht.

TÍTULO / TITLE:  - Metastatic liposarcoma of the heart : Case series and brief literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Herz. 2013 Feb 23.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00059-013-3768-4

AUTORES / AUTHORS:  - Pino PG; Zampi G; Pergolini A; Pero G; Polizzi V; Sbaraglia F; Minardi G; Musumeci F

INSTITUCIÓN / INSTITUTION:  - Department of Cardiovascular Science, “S. Camillo-Forlanini” Hospital, Rome, Italy.

RESUMEN / SUMMARY:  - Secondary cardiac tumors are 20-40 times more frequent than primary lesions. Primary cardiac lesions are represented by myxomas when related to benign tumors, and by sarcomas in terms of malignant disease. Metastases to the heart from liposarcomas are very rare. We present three cases of secondary liposarcomas involving the left atrium, the right atrium, and the pericardium.




TÍTULO / TITLE:  - Primary rhabdomyosarcoma of the diaphragm: case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Surg. 2013 Apr;17(4):799-804. doi: 10.1007/s11605-013-2158-9. Epub 2013 Feb 9.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11605-013-2158-9

AUTORES / AUTHORS:  - Melis M; Rosen G; Hajdu CH; Pachter HL; Raccuia JS

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, New York University Langone Medical Center, New York, NY,  10016, USA, marcovalerio.melis@nyumc.org.

RESUMEN / SUMMARY:  - BACKGROUND: Diaphragmatic sarcomas are extremely rare and mostly described in children. We present the case of an adult with rhabdomyosarcoma of the diaphragm. METHODS: We performed a literature review, highlighted possible diagnostic pitfalls, and discussed multidisciplinary treatment options.




TÍTULO / TITLE:  - Mastoid osteoma: A case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ear Nose Throat J. 2013 Mar;92(3):E7-9.

AUTORES / AUTHORS:  - Cheng J; Garcia R; Smouha E

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.

RESUMEN / SUMMARY:  - We describe the case of a 22-year-old woman who presented with a slowly growing osseous lesion of the mastoid cortex. On computed tomography, the lesion was found to involve the mastoid cortex, with which it demonstrated similar attenuation. The indications for treatment in this case were the patient’s sensation of a mass effect, the encroachment of the mass onto the external auditory meatus, and a cosmetic deformity. The tumor was removed in its entirety  via a postauricular approach. Findings on histopathologic examination were consistent with a compact osteoma. Mastoid osteomas are rare, benign tumors. If their growth significantly occludes the meatus, they may cause cosmetic deformities, conductive hearing loss, and recurrent external ear infections. Several other osseous lesions of the temporal bone should be considered in the differential diagnosis. The etiology of mastoid osteomas is poorly understood. Surgical management can be undertaken with minimal postoperative morbidity.




TÍTULO / TITLE:  - Spinal fibromatosis: a report of two cases and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Spine J. 2013 Mar 21. pii: S1529-9430(13)00171-X. doi: 10.1016/j.spinee.2013.02.014.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.spinee.2013.02.014

AUTORES / AUTHORS:  - Shakur SF; Takagi I; Jacobsohn JA; Golden BM; Karahalios DG

INSTITUCIÓN / INSTITUTION:  - Section of Neurosurgery, University of Chicago Medical Center, 5841 South Maryland Ave., Chicago, IL 60637, USA. Electronic address: sophiashakur@uchicago.edu.

RESUMEN / SUMMARY:  - BACKGROUND CONTEXT: Spinal fibromatosis is a unique subset of fibromatosis that is only anecdotally described in the literature in sporadic case reports. According to our review of the literature, only 11 cases of spinal fibromatosis have been previously documented. This paucity of clinical data limits our understanding of its presentation and treatment. PURPOSE: The authors present the first two cases of spinal fibromatosis encountered at their institution, and review the literature of reported cases to elucidate the presentation and outcomes of patients with this rare tumor. STUDY DESIGN: A report of two cases and review of the literature. METHODS: The two patients in our case report were women aged 45 and 38 years. Both of the patients presented to our clinic after previous excisional biopsy of a spinal mass, 17 years and 1 year later, respectively, with pain and paresthesias that recapitulated their former symptoms. Thirteen cases, including the two described in the current article, were culled from the literature. RESULTS: Magnetic resonance imaging revealed an  enhancing lesion in the posterior elements of the spinal column in the first case and a paraspinal soft tissue mass in the second case. The tumors were histologically defined by haphazardly arranged, elongated, and slender spindle cells separated by abundant collagen without mitoses or necrosis. Surgical management resulted in intralesional resection in the first case and en bloc resection in the second case. By 40 and 10 months after surgery, both patients remain without neurologic deficits. CONCLUSIONS: Among 13 cases of spinal fibromatosis, pain with or without a mass is the most common symptom at presentation. Tumor etiology is evenly distributed between de novo origin and surgical trauma. Treatment outcomes, although, cannot be determined from the limited data currently available.




TÍTULO / TITLE:  - Primary liver sarcomatous carcinoma: Report of two cases and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Res Pract. 2013 Feb 25. pii: S0344-0338(13)00006-X. doi: 10.1016/j.prp.2013.01.005.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.prp.2013.01.005

AUTORES / AUTHORS:  - Giunchi F; Vasuri F; Baldin P; Rosini F; Corti B; D’Errico-Grigioni A

INSTITUCIÓN / INSTITUTION:  - “F. Addarii” Institute of Oncology and Transplantation Pathology, S. Orsola-Malpighi Hospital, Bologna University, Italy.

RESUMEN / SUMMARY:  - Primary liver sarcomatous carcinomas (PLSCs) are very aggressive tumors. They are characterized by a fast clinical course, and therefore need a prompt histological diagnosis. Here, we report two cases of PLSC. One arises in a non-cirrhotic liver and the other in cirrhosis, with differences in onset and histological features.  Special emphasis is put on the expression of albumin and HCC markers, and their possible usefulness in the diagnosis. The English literature of the last 20 years was revised (92 cases). Immunohistochemistry was performed manually or automatically; in situ hybridization (ISH) technique for albumin mRNA detection was carried out. The sarcomatoid components in both cases were immunoreactive for K8/18, Glutamine Synthetase and EZH2, and negative for Glypican 3, SMA, caldesmon, desmin, DOG-1, CD34, CD31, CD117, CD56, and alpha-fetoprotein. The detection of albumin mRNA by ISH was negative in the sarcomatoid component in both cases. PLSC represents a diagnostic challenge for pathologists, especially in its “pure” form: neither albumin mRNA detection nor HCC markers are useful for the diagnosis: positivity for K8/18 and the negativity for the mesenchymal markers seem to represent the main tools for the histological diagnosis.




TÍTULO / TITLE:  - Giant cell tumor of bone.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Am Acad Orthop Surg. 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118.

            ●● Enlace al texto completo (gratuito o de pago) 5435/JAAOS-21-02-118

AUTORES / AUTHORS:  - Raskin KA; Schwab JH; Mankin HJ; Springfield DS; Hornicek FJ

INSTITUCIÓN / INSTITUTION:  - Massachusetts General Hospital, Boston, MA, USA.

RESUMEN / SUMMARY:  - Giant cell tumor (GCT) of bone is one type of giant cell-rich lesion of bone. This benign mesenchymal tumor has characteristic multinuclear giant cells. Mononuclear stromal cells are the physiologically active and diagnostic cell type. Most GCTs are located in the epiphyseal regions of long bones. The axial skeleton-primarily the sacrum-is a secondary site of involvement. Most patients present with pain, swelling, joint effusion, and disability in the third and fourth decades of life. Imaging studies are important for tumor staging and radiographic grading. Typically, these clinically active but slow-growing tumors  are confined to bone, with relatively well-defined radiographic borders. Monostotic disease is most common. Metastatic spread to the lungs is rare. Extended intralesional curettage with or without adjuvant therapy is the primary  treatment choice. Local recurrence is seen in </= 20% of cases, and a second local intralesional procedure is typically sufficient in cases that are detected  early. Medical therapies include diphosphonates and denosumab. Denosumab has been approved for use in osteoporosis as well as breast and prostate cancer metastatic to bone. Medical therapy and radiotherapy can alter the management of GCT of bone, especially in multifocal disease, local recurrences, and bulky central/axial disease.




TÍTULO / TITLE:  - A rare case of fever of unknown origin: inflammatory myofibroblastic tumor of the liver. Case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Gastroenterol Belg. 2012 Dec;75(4):448-53.

AUTORES / AUTHORS:  - Kruth J; Michaely H; Trunk M; Niedergethmann M; Rupf AK; Kramer BK; Gottmann U

INSTITUCIÓN / INSTITUTION:  - 3rd Department of Medicine (Hematology and Oncology), University Hospital Mannheim, University of Heidelberg, Mannheim, Germany. jens.kruth@web.de

RESUMEN / SUMMARY:  - We present the case of a rare cause of fever of unknown origin (FUO). FUO is challenging for patients as well as for physicians as there are more than 200 differential diagnoses of FUO (1,2). Pointing out a diagnosis often requires numerous noninvasive and invasive procedures that sometimes even fail to explain  the fever. Our patient was admitted twice to our hospital due to remitting fever  rising up to 40 degrees C without any subjective discomfort. At the first presentation no clinical focus could be identified. This included the examination of multiple blood and urine cultures, serology, autoimmune serology, transesophageal echocardiography, CT-scan of the lung and the abdomen, and bone scintigraphy. Elevated C-reactive protein (268 mg/l) decreased spontaneously and  fever disappeared after 4 weeks. However, the patient was re-admitted 4 months later with identical symptoms. Multiple blood and urine cultures, serology, bone  marrow examination, CT-scan of the lung and the abdomen, esophago-gastro-duodenoscopy and colonoscopy still showed no pathological findings. MRI-scan of the abdomen identified a liver tumor of 3.3 cm in diameter  in segment 6 without typical signs of an adenoma, focal nodular hyperplasia or hepatocellular carcinoma. Biopsy of the suspect liver lesion revealed an inflammatory myofibroblastic tumor (inflammatory pseudotumor). After surgical resection of the tumor elevated inflammation markers as C-reactive protein normalized and fever disappeared. One year after surgery no more episodes of fever re-occurred. An inflammatory myofibroblastic tumor of the liver can be a rare cause of fever of unknown origin. MRI-scan can be an additional imaging tool to identify previously not recognized liver tumors.




TÍTULO / TITLE:  - Large sacral osteoblastoma: a case report and review of multi-disciplinary management strategies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J La State Med Soc. 2012 Sep-Oct;164(5):251-5.

AUTORES / AUTHORS:  - Khan IS; Thakur JD; Chittiboina P; Nanda A

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, USA.

RESUMEN / SUMMARY:  - INTRODUCTION: Osteoblastomas are uncommon primary benign bone tumors. The sacrum  is an uncommon site of involvement. We present a case of a large, technically challenging sacral osteoblastoma in a pediatric patient that was managed with en-bloc resection and lumbo-sacral reconstruction showing long-term remission. CASE REPORT: A 15-year-old Hispanic male presented to our clinic in May 2006 with low back pain. Imaging revealed a large expansile and erosive mass at the S2 vertebral body. Definitive treatment of the lesion with en-bloc surgical resection was planned after a biopsy that confirmed osteoblastoma. The patient underwent pre-operative embolization and a same-day, two-stage resection of the tumor with lumbosacral instrumentation for pelvic reconstruction. The S1 nerve roots were sacrificed during en-bloc resection of the mass. Post-operatively, the patient developed an areflexic bladder without major motor or sensory impairment. Subsequently, insertion of an artificial urinary sphincter and a colostomy were performed. At the five-year follow up, the patient remains symptom free with no detectable recurrence. CONCLUSION: The sacrum is a known, but rare, location for  an osteoblastoma. We present a technically challenging case of a pediatric patient with a large sacral osteoblastoma. We highlight the importance of a multidisciplinary approach to ensure a long-term, disease-free outcome.




TÍTULO / TITLE:  - AIDS related Kaposi’s sarcoma presenting with palatal and eyelid nodule.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Assoc Physicians India. 2012 Jul;60:50-3.

AUTORES / AUTHORS:  - Joshi U; Ceena DE; Ongole R; Sumanth KN; Boaz K; Jeena Priy K; Srikan N

INSTITUCIÓN / INSTITUTION:  - Department of Oral Medicine and Radiology, Manipal College of Dental Science, Mangalore, Manipal University.

RESUMEN / SUMMARY:  - Kaposi sarcoma is a low-grade vascular neoplasm associated with Human Herpesvirus-8 (HHV8) infection. Although India has a large HIV infected population, Kaposi’s sarcoma is rare and only 12 cases of AIDS related Kaposi’s sarcoma from India have been reported in the published literature to our knowledge. The 50% of total cases in India has been reported from Mumbai. The incidence of AIDS related Kaposi’s sarcoma is increasing as more than 50% of the  cases are reported in 2008 to 2010. SUMMARY: We report a case of 26-year-old, HIV seropositive, Indian male with multiple, non-blanching, purplish blue nodular swellings in the palate and right upper eye lid. Similar lesions were also present on the face and the extremities. On the basis of clinical and histopathological examination, a diagnosis of AIDS related Kaposi’s sarcoma was made.




TÍTULO / TITLE:  - Management of sinonasal chondrosarcoma: a systematic review of 161 patients.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int Forum Allergy Rhinol. 2013 Mar 20. doi: 10.1002/alr.21162.

            ●● Enlace al texto completo (gratuito o de pago) 1002/alr.21162

AUTORES / AUTHORS:  - Khan MN; Husain Q; Kanumuri VV; Boghani Z; Patel CR; Liu JK; Eloy JA

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology-Head and Neck Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ.

RESUMEN / SUMMARY:  - BACKGROUND: This study reviews the published literature related to management of  sinonasal chondrosarcoma. Clinical presentation, demographics, radiographic diagnosis, treatment, and management outcomes of this uncommon disease are reported. METHODS: A systematic review of studies for sinonasal chondrosarcoma from 1950 to 2012 was conducted. A PubMed search for articles related to this condition, along with bibliographies of the selected articles was performed. Articles were examined for patient data that reported survivability. Demographic  data, disease site, treatment strategies, follow-up, outcome, and survival were analyzed. RESULTS: A total of 63 journal articles were included, comprising a total of 161 cases of sinonasal chondrosarcoma. The average follow-up was 77.4 months (range, 1 to 325.2 months). Surgical resection was the most common treatment modality, used in 72.0% of cases. A combination of surgery and radiation therapy was the second most commonly used treatment modality, used in 21.7% of cases. CONCLUSION: This review contains the largest pool of sinonasal chondrosarcoma patients to date and suggests aggressive surgical resection is the most common treatment modality for this condition. The use of adjuvant radiotherapy for prevention of local recurrence after subtotal or total resection has not been proven effective. However, the use of radiotherapy in addition to surgical resection has shown benefit in some studies in terms of survival.



TÍTULO / TITLE:  - Iatrogenic implantation of giant cell tumor at bone graft donor site and clinical recommendations to prevent “A Rare Avoidable Complication”

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Orthop Surg Traumatol. 2012 Aug 8.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00590-012-1055-3

AUTORES / AUTHORS:  - Gulia A; Puri A; Salunke A; Desai S; Jambhekar NA

INSTITUCIÓN / INSTITUTION:  - Orthopedic Oncology, Room no: 27, Bone and Soft Tissue Services, Tata Memorial Hospital, E. Borges Marg, Parel, Mumbai, 400012, Maharashtra, India, aashishgulia@gmail.com.

RESUMEN / SUMMARY:  - The treatment of giant cell tumor of bone is directed toward local control without sacrificing joint function. This is achieved by intralesional curettage.  When autograft is used for the reconstruction of the curetted cavity, there is always a theoretical risk of contamination of graft donor site. We report a case  of iatrogenic implantation of giant cell tumor at the bone graft donor site after intralesional curettage and bone grafting of giant cell tumor of distal femur. Patient was treated with repeat intralesional curettage and excision of implantation lesion at bone graft donor site. We recommend precautionary measures to prevent this avoidable complication.



TÍTULO / TITLE:  - Clinical and endoscopic features of angiosarcoma of the colon: two case reports and a review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Cancer. 2013 Mar;44(1):12-21. doi: 10.1007/s12029-012-9431-0.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12029-012-9431-0

AUTORES / AUTHORS:  - Sherid M; Sifuentes H; Brasky J; Shah DA; Ehrenpreis ED

INSTITUCIÓN / INSTITUTION:  - Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA.

RESUMEN / SUMMARY:  - BACKGROUND: Angiosarcoma of the gastrointestinal tract is an extremely rare tumor. We present two cases of angiosarcoma of the colon. One patient developed syncope and anemia and the other had rectal bleeding. DISCUSSION: Endoscopic findings of the colon were different; the first case demonstrated a reddened colonic fold without an obvious mass and the other had an ulcerated friable mass. Both of the tumors had positive immunohistochemical stains for CD31 and CD34 (one was also positive for CD117). Surgery was not performed in either case. Treatment included chemotherapy with imatinib for the first patient and paclitaxel for the  second. Prognosis for this tumor is generally poor; in our cases, one patient was still alive after 5 months of follow-up and the other died within 2 months of diagnosis. After presenting our cases, we reviewed the current literature on angiosarcoma of the colon.



TÍTULO / TITLE:  - Trabectedin in the neoadjuvant treatment of high-grade pleomorphic sarcoma: report of a rare case and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol Med. 2013;2013:320797. doi: 10.1155/2013/320797. Epub 2013 Jan 16.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/320797

AUTORES / AUTHORS:  - Schuler MK; Richter S; Platzek I; Beuthien-Baumann B; Wieczorek K; Hamann C; Mohm J; Ehninger G

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, Germany.

RESUMEN / SUMMARY:  - Background. Pleomorphic sarcoma is an aggressive soft tissue sarcoma. In patients with high-risk extremity sarcomas, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery were reported. To our knowledge, this is the first report in the literature of the neoadjuvant use  of trabectedin in a patient with high-grade pleomorphic sarcoma, ineligible for standard neoadjuvant combination therapy with an anthracycline-based regimen. Case Presentation. Here we present a 58-year-old White male with a large tumor in the left thigh, but with no signs of metastases. Owing to the history of severe heart attack, three cycles of neoadjuvant trabectedin were administrated to achieve surgically wide margins. After two cycles, an 18F-FDG-PET showed a large  proportion of the central tumor area was without metabolic activity. According to RECIST and Choi criteria, the tumor was stable. After the third cycle of trabectedin, the patient underwent a complete resection, which revealed completely necrotic high-grade pleomorphic sarcoma (stage pT2b), with only a small vital area. Conclusion. The present paper on a promising treatment with neoadjuvant trabectedin of patients with high-grade pleomorphic sarcoma might suggest that such treatment approach may provide a greater chance of cure and survival of such patients.



TÍTULO / TITLE:  - Desmoplastic fibroma: a case report with three years of clinical and radiographic observation and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Open Orthop J. 2013;8:40-6. doi: 10.2174/1874325001307010040. Epub 2013 Feb 13.

            ●● Enlace al texto completo (gratuito o de pago) 2174/1874325001307010040

AUTORES / AUTHORS:  - Nedopil A; Raab P; Rudert M

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery at the University of Wurzburg, Konig Ludwig Haus, Germany.

RESUMEN / SUMMARY:  - BACKGROUND: Desmoplastic fibroma (DF) is an extremely rare locally aggressive bone tumor with an incidence of 0.11% of all primary bone tumors. The typical clinical presentation is pain and swelling above the affected area. The most common sites of involvement are the mandible and the metaphysis of long bones. Histologically and biologically, desmoplastic fibroma mimics extra-abdominal desmoid tumor of soft tissue. CASE PRESENTATION AND LITERATURE REVIEW: A case of  a 27-year old man with DF in the ilium, including the clinical, radiological and  histological findings over a 4-year period is presented here. CT scans performed  in 3-year intervals prior to surgical intervention were compared with respect to  tumor extension and cortical breakthrough. The patient was treated with curettage and grafting based on anatomical considerations. Follow-up CT scans over 18-months are also documented here. Additionally, a review and analysis of 271 cases including the presented case with particular emphasis on imaging patterns in MRI and CT as well as treatment modalities and outcomes are presented. CONCLUSION: In patients with desmoplastic fibroma, CT is the preferred imaging technique for both the diagnosis of intraosseus tumor extension and assessment of cortical involvement, whereas MRI is favored for the assessment of extraosseus tumor growth and preoperative planning. While tumor resection remains the preferred treatment for DF, curettage and grafting prove to be an acceptable alternative treatment modality with close follow-up when resection is not possible. Curettage and grafting have been shown to provide good clinical results and are associated with long recurrence free intervals.



TÍTULO / TITLE:  - Painful elastofibroma dorsi: a report of a case and a brief review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Orthop. 2013;2013:794247. doi: 10.1155/2013/794247. Epub 2013 Jan 14.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/794247

AUTORES / AUTHORS:  - Falidas E; Arvanitis D; Anyfantakis G; Pazidis A; Koukouli Z; Miltiadou D; Koronaiou A

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Florina General Hospital, Egnatias 9, 53100 Florina, Greece.

RESUMEN / SUMMARY:  - Elastofibroma dorsi (ED) is an uncommon, slow-growing, benign, soft tissue tumor  of unclear pathogenesis, typically located at the subscapular region of elderly people. It may be unilateral or bilateral. Though many patients are asymptomatic, ED can cause local deformity and symptoms such as periscapular pain or discomfort. Herein we report a case of a 65-year-old woman with painful ED. Clinical features, radiodiagnostic, intraoperative, and pathologic findings, and  a brief review of the literature are performed.



TÍTULO / TITLE:  - Lymph node metastasis after a soft tissue sarcoma of the leg: a case report and a review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Surg. 2013;2013:930361. doi: 10.1155/2013/930361. Epub 2013 Feb 6.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/930361

AUTORES / AUTHORS:  - Nelen SD; Vogelaar FJ; Gilissen F; Van der Linden JC; Bosscha K

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ ‘s-Hertogenbosch, The Netherlands.

RESUMEN / SUMMARY:  - Introduction. Soft tissue sarcomas (STSs) represent 1 percent of all adult malignancies and sarcomas only rarely spread to the regional lymph nodes. Case Presentation. We present a case of a woman with a dermatofibrosarcoma protuberans and a sarcoma not therwise specified of the lower extremity. The patient had no distant metastasis during follow-up, but did develop a regional lymph nodemetastasis (RLNM) in the groin. We reviewed the literature about RLNM in STSs. Discussion. Reviewing the literature we see that within specific histological types RLNM occurs as often as distant metastasis. Furthermore RLNM occurs in over 10% for specific histological types and in 24% of all patients with a soft tissue sarcoma of the lower extremity. Except for radical lymphadenectomy with a 5-year survival rate of 46% there is no appropriate treatment. Conclusion. The risk for a RLNM in certain histological types and anatomical locations might transcend the risk for a distant lung metastasis.



TÍTULO / TITLE:  - Peripheral odontogenic myxoma: a review of the literature and report of two cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Maxillofac Oral Surg. 2012 Mar;11(1):101-4. doi: 10.1007/s12663-011-0194-0. Epub 2011 Apr 19.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12663-011-0194-0

AUTORES / AUTHORS:  - Raubenheimer EJ; Noffke CE

INSTITUCIÓN / INSTITUTION:  - Oral Pathology, School of Oral Health Sciences, University of Limpopo, Box D24, Medunsa Campus, Medunsa, 0204 South Africa.

RESUMEN / SUMMARY:  - Two cases of peripheral odontogenic myxoma with a verifiable location in gingival soft tissue and without bone involvement were compared with those reported in the literature. This study showed that they form a distinct albeit rare clinical entity with a potential to grow into large disfiguring lesions. The probability that small peripheral odontogenic myxomas are interpreted as edematous irritation fibromas may contribute to the small number of peripheral odontogenic myxomas recorded in the literature. The differential diagnosis of soft tissue myxoid proliferations is discussed.



TÍTULO / TITLE:  - Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Mar;5(3):739-742. Epub 2012 Dec 19.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1087

AUTORES / AUTHORS:  - Gao J; Fei L; Li S; Cui K; Zhang J; Yu F; Zhang B

INSTITUCIÓN / INSTITUTION:  - Department of Hepatobiliary Surgery, Shandong Cancer Hospital, Jinan 250117;

RESUMEN / SUMMARY:  - Over 200 cases of undifferentiated embryonal sarcoma of the liver (UESL) have been reported since 1978 when this disease was first described. In the present study, we describe a case of UESL in a 7-year-old female, whose initial symptoms  included swelling in the upper abdomen and a palpable enormous irregular tumor. A magnetic resonance imaging (MRI) examination revealed a massive focal lesion in the right lobe of the liver. Hepatic malignant tumor with a high possibility of hepatoblastoma was diagnosed. The tumor was surgically removed and confirmed to be UESL by postoperative pathology and immunohistochemical staining analysis. The patient then received chemotherapy consisting of three cycles of epirubicin (20 mg, days 1-2) and cisplatin (15 mg, days 1-3). To date, the patient has survived  for 22 months, and is currently in a good general condition without evidence of local metastasis or recurrence. Although UESL has a high malignancy and a poor prognosis, cases of long-term survival with improved diagnosis and therapy have recently been reported. Therefore, it has been proposed that UESL should not be considered as an hepatic tumor with a poor prognosis. Total resection with preoperative or postoperative radio-chemotherapy is currently considered to be the key approach to improving the survival rate.



TÍTULO / TITLE:  - Primary inflammatory myofibroblastic tumor of the stomach in an adult woman: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Feb 4;11:35. doi: 10.1186/1477-7819-11-35.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-35

AUTORES / AUTHORS:  - Bjelovic M; Micev M; Spica B; Babic T; Gunjic D; Djuric A; Pesko P

INSTITUCIÓN / INSTITUTION:  - University of Belgrade, Belgrade, Serbia. m.bjelovic@med.bg.ac.rs

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumor has been defined as a histologically distinctive lesion with uncertain behaviour. The term inflammatory myofibroblastic tumor more commonly referred to as “pseudostumor “, denotes a pseudosarcomatous inflammatory lesion that contains spindle cells, myofibroblasts, plasma cells, lymphocytes and histiocytes. It exhibits a variable biological behavior that ranges from frequently benign lesions to more aggressive variants. Inflammatory myofibroblastic tumor mostly occurs in the soft tissue of  children and young adults, and the lungs are the most commonly affected site, but it has been recognized that any anatomic localization can be involved. Inflammatory myofibroblastic tumors in adults are very rare, especially in the stomach. We present a case of a 43-year old woman with primary inflammatory myofibiroblastic tumor in the stomach and a review of the literature.



TÍTULO / TITLE:  - Juxtacortical clavicular chondrosarcoma: diagnostic dilemmas: case report and review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Med Insights Oncol. 2013;7:13-9. doi: 10.4137/CMO.S10542. Epub 2013 Jan 22.

            ●● Enlace al texto completo (gratuito o de pago) 4137/CMO.S10542

AUTORES / AUTHORS:  - Efremidou EI; Oikonomou A; Pavlidou E; Drosos G; Koutsopoulos A; Liratzopoulos N

INSTITUCIÓN / INSTITUTION:  - First Surgical Department, Medical School, Democritus University of Thrace, University Hospital of Alexandroupolis.

RESUMEN / SUMMARY:  - Juxtacortical chondrosarcoma is a rare primary malignant cartilaginous tumor accounting for 0.2% of all bone tumors. Wide surgical resection is the treatment  of choice for juxtacortical chondrosarcomas. Accurate preoperative diagnosis is important in ensuring appropriate management, staging, and treatment of the patient. A combination of radiographs, three-dimensional imaging with computerized tomography (CT) scan and magnetic resonance imaging (MRI) can typically allow accurate diagnosis of juxtacortical chondrosarcomas. Bone scan and chest x-ray or CT chest scans are indicated for appropriate staging of the patient. Pet scan, ultrasound, bone scan, etc. are not typically needed for the diagnosis. Certainly, pulmonary imaging and bone scan are required for staging and could be commented upon.



TÍTULO / TITLE:  - A giant intradiploic angiolipoma of the skull: controversies in diagnosis of skull bone lesions.Report of the second case reported in the literature and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Inj Violence Res. 2012 Nov;4(3 Suppl 1). pii: Paper No. 40.

AUTORES / AUTHORS:  - Ghassemi B; Amirjamshidi A

INSTITUCIÓN / INSTITUTION:  - Arad General Hospital, Tehran University of Medical Sciences, Tehran, Iran.

RESUMEN / SUMMARY:  - The present study reports a very rare case of giant intradiploic angiolipoma. To  our knowledge this is the second case reported of an intradiploic angiolipoma that occurred in the calvarium. We present a short controversial discussion regarding the new aspects in differential diagnosis of skull mass lesions according to the findings of this very rare case. KEYWORDS: Skull, Bone, Lesions.



TÍTULO / TITLE:  - Large perineal and gluteal angiomyxoma: the role of diagnostic imaging and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Feb 20;2013. pii: bcr2013008680. doi: 10.1136/bcr-2013-008680.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-008680

AUTORES / AUTHORS:  - Alhabshi SM; Abd Rashid M

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia. shmajedah@yahoo.com

RESUMEN / SUMMARY:  - Aggressive angiomyxoma is a benign soft tissue tumour usually affecting the pelvis and perineum predominantly in women. Because of its variable presentation, this tumour is often clinically misdiagnosed as liposarcoma. We describe a case of a 38-year-old woman who presented with a large perineal and gluteal mass which increased in size in one year. Ultrasound showed hypoechoic mixed solid and cystic mass. Contrasted CT and MRI examinations showed typical appearance of swirling and layering pattern. She had undergone TAHBSO as the mass was difficult to dissect intra-operatively. The post-operative specimen confirmed to be an aggressive angiomyxoma.



TÍTULO / TITLE:  - An unusual location of juvenile angiofibroma: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Otolaryngol. 2013;2013:175326. doi: 10.1155/2013/175326. Epub 2013 Feb 16.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/175326

AUTORES / AUTHORS:  - Pillenahalli Maheshwarappa R; Gupta A; Bansal J; Kattimani MV; Shabadi SS; Baser SC

INSTITUCIÓN / INSTITUTION:  - Department of Radiodiagnosis, Ravindra Nath Tagore Medical College, Udaipur 313001, India.

RESUMEN / SUMMARY:  - A 10-year-old boy presented with left-sided nasal obstruction and epistaxis. Endoscopic evaluation revealed a polypoid mass in the vestibule arising from the  lateral wall of the nasal cavity anteroinferior to the left inferior turbinate. Computed tomography (CT) scan showed a soft tissue opacity in the vestibule of the left nasal cavity. After the endoscopic excision of the mass, postoperative and histopathological analyses confirmed the diagnosis of an angiofibroma.



TÍTULO / TITLE:  - Paratesticular liposarcoma: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Urol. 2013;2013:806289. doi: 10.1155/2013/806289. Epub 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/806289

AUTORES / AUTHORS:  - Alyousef H; Osman EM; Gomha MA

INSTITUCIÓN / INSTITUTION:  - Urology Department, King Fahad Specialist Hospital, Dammam 15215, Saudi Arabia.

RESUMEN / SUMMARY:  - Introduction. Liposarcoma is a rare pathological entity. By far it is the most common histological subtype of genitourinary sarcomas in adults. Approximately two hundred cases were reported in the literature. We are hereby presenting a case with a typical clinical scenario of paratesticular liposarcoma. Case report. A 75-year-old gentleman presented with a painless right hemiscrotal swelling that was progressively increasing in size over the last 6 years. Testicular tumour markers were negative. Imaging showed a heterogenous mass with fat component. Subsequently he underwent wide local excision that included the paratesticular mass along with the right testicle and all right inguinal canal contents up to the deep inguinal ring with the sparing of right illioinguinal nerve. Histopathological examination showed a well differentiated liposarcoma of the spermatic cord. He remained recurrence-free so far after 18 months of followup. Conclusion. Radical orchidectomy with wide local excision comprises the cornerstone of treatment of paratesticular liposarcoma. Due to the rarity of the  disease there is no definite universal consensus of opinion as regards the role of radiotherapy and chemotherapy.



TÍTULO / TITLE:  - Spontaneous rupture of primary splenic angiosarcoma: a case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Mar 4;11:53. doi: 10.1186/1477-7819-11-53.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-53

AUTORES / AUTHORS:  - Duan YF; Jiang Y; Wu CX; Zhu F

INSTITUCIÓN / INSTITUTION:  - Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213000, Changzhou, Jiangsu, China. dahe1971@163.com.

RESUMEN / SUMMARY:  - BACKGROUND: Primary angiosarcoma of the spleen is a rare mesenchymal malignant tumor of vascular origin often with a poor prognosis, due to its high metastatic  potential. This disease often presents with atraumatic rupture and lethal hemorrhage. CASE PRESENTATION: We report a case of a 65-year-old man who presented with abdominal pain, anemia, thrombocytopenia, and palpable abdominal mass with unstable blood pressure. Laparotomy revealed a huge actively bleeding spleen, thus splenectomy was performed. Some liver metastasis foci were also found during the procedure. Histopathology diagnosis of the removed spleen was primary splenic angiosarcoma. The patient was discharged on the 10th day post operation with no complication. CONCLUSIONS: Splenic angiosarcoma should be considered one of the differential diagnoses in patients with spleen parenchymal  lesions. Definitive diagnosis requires laparotomy followed by splenectomy. In the majority of the patients with spleen angiosarcoma, metastatic diseases have already occurred at the time of laparotomy, so splenectomy is an approach more for diagnostic purpose rather than curative purpose.



TÍTULO / TITLE:  - Angiomatoid fibrous histiocytoma: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Radiol Case Rep. 2012 Nov;6(11):8-15. doi: 10.3941/jrcr.v6i11.932. Epub 2012 Nov 1.

            ●● Enlace al texto completo (gratuito o de pago) 3941/jrcr.v6i11.932

AUTORES / AUTHORS:  - Bauer A; Jackson B; Marner E; Gilbertson-Dahdal D

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, University of Arizona Health Sciences Center, Tucson, AZ, USA. adam.herman.bauer@gmail.com

RESUMEN / SUMMARY:  - Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor most commonly  occurring in children, adolescents, and young adults. Clinically and radiographically the lesion is easily confused with a hematoma, soft tissue hemangioma, or malignant fibrous histiocytoma. While the lesion is rare, due to the potential for local recurrence and metastasis, it is imperative to consider this lesion in the differential diagnosis of a soft tissue mass in a child or adolescent. Here, we present the clinical, radiologic, and pathologic findings of a case of AFH.



TÍTULO / TITLE:  - Primary mediastinal myelolipoma: A case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Mar;5(3):862-864. Epub 2012 Dec 19.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1085

AUTORES / AUTHORS:  - Geng C; Liu N; Yang G; Qi M; Chen W

INSTITUCIÓN / INSTITUTION:  - Departments of Hematology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.

RESUMEN / SUMMARY:  - Myelolipoma is a rare, benign neoplasm composed of mature adipocytes and hematopoietic tissue, mainly occurring in the adrenal glands. The majority of extra-adrenal myelolipomas have been identified in the presacral region and primary mediastinal myelolipoma is very rare. Computed tomography (CT) and magnetic resonance imaging (MRI) are effective methods to detect myelolipoma, while fine-needle aspiration (FNA) combined pathology is able to definitively rule out malignancy. There is no standard method of treatment for the disease. Small (<4 cm) asymptomatic tumors should be monitored, while symptomatic tumors or large (>7 cm) myelolipomas should be removed by surgery. This study describes  a patient who presented with two mediastinal myelolipomas that were not encapsulated and presented as a string-of-pearls-type. The pathological diagnosis was myelolipoma and the patient did not relapse within the three years following  resection.



TÍTULO / TITLE:  - Peripheral cemento-ossifying fibroma: case series literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Dent. 2013;2013:930870. doi: 10.1155/2013/930870. Epub 2013 Jan 14.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/930870

AUTORES / AUTHORS:  - Ganji KK; Chakki AB; Nagaral SC; Verma E

INSTITUCIÓN / INSTITUTION:  - Department of Periodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed University), Nagpur, India.

RESUMEN / SUMMARY:  - THE CONCEPT OF FIBROOSSEOUS LESIONS OF BONE HAS EVOLVED OVER THE LAST SEVERAL DECADES AND NOW INCLUDES TWO MAJOR ENTITIES: fibrous dysplasia and ossifying fibroma. Peripheral cemento-ossifying fibroma is a relatively rare tumour classified between fibroosseous lesions. It predominantly affects adolescents and young adults, with peak prevalence between 10 and 19 yrs. The cemento-ossifying fibroma is a central neoplasm of bone as well as periodontium which has caused considerable controversy because of confusion regarding terminology and the criteria for its diagnosis. The cemento-ossifying fibroma is odontogenic in origin, whereas ossifying fibroma is of bony origin. Lesions histologically similar to peripheral ossifying fibroma have been given various names in existing literature. Therefore, we present and discuss in this paper a series of cases of  peripheral cemento-ossifying fibroma emphasizing the differential diagnosis.



TÍTULO / TITLE:  - Lung metastasis from perineal leiomyosarcoma: a case report and a review of the Japanese literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Med. 2013;2013:496304. doi: 10.1155/2013/496304. Epub 2013 Mar 5.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/496304

AUTORES / AUTHORS:  - Itoga M; Ito W; Ueki S; Takeda M; Moritoki Y; Kobayashi Y; Chihara M; Suzuki N; Sasaki H; Chihara J

INSTITUCIÓN / INSTITUTION:  - Department of Infection, Allergy, Clinical Immunology and Laboratory Medicine, Akita University Graduate School of Medicine, 1-1-1, Hondo, Akita 010-8543, Japan.

RESUMEN / SUMMARY:  - Pulmonary metastasis from leiomyosarcoma is rare and its clinical management is challenging. A single lung metastasis from a perineal leiomyosarcoma occurred in  a 79-year-old woman. Five months after resection of the lung metastasis, a new metastatic tumor developed in the contralateral lung. Since the patient did not desire to receive hospitalized treatment, TS-1 (an oral agent consisting of a combination of tegafur, gimeracil, and oteracil potassium) therapy was started on an outpatient basis. The lung metastasis has been successfully controlled for at  least 17 months with excellent tolerability. The clinical features and the treatment of this case are discussed.



TÍTULO / TITLE:  - Osteoblastoma of the carpal navicular: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Orthop Surg Traumatol. 2012 Jul 4.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00590-012-1030-z

AUTORES / AUTHORS:  - Rhanim A; El Bardouni A; Dlimi F; Abouzahir M; Berrada MS; El Yaacoubi M

INSTITUCIÓN / INSTITUTION:  - , Avenue Annakhil, Residence Riad Al Otor, bloc C, Immeuble A, Appartement 21, Hay Riad, Rabat, Morocco, rhanimabdelkarim@gmail.com.

RESUMEN / SUMMARY:  - Osteoblastoma of the scaphoid is an infrequent cause of hand and wrist pain. The  few reported cases emphasize the rarity of osteoblastoma in hand and wrist localizations. Pathological examination is mandatory before treatment due to lack of distinctive clinical and radiological features. We report the case of a 17-year-old right-handed girl who presented with a more than 7-month history of progressive right-wrist pain. No history of trauma was reported. Conservative treatment with anti-inflammatory medications before referral was unsuccessful. The authors present the diagnostic difficulties and the treatment that was applied: proximal row carpectomy. Treatment options, according to the literature, also include scaphoidectomy and tumor curettage with bone grafting.



TÍTULO / TITLE:  - A rare primary tumor of the thyroid gland: report a new case of leiomyosarcoma and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2013 Feb 27;8:36. doi: 10.1186/1746-1596-8-36.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-8-36

AUTORES / AUTHORS:  - Amal B; El Fatemi H; Souaf I; Moumna K; Affaf A

INSTITUCIÓN / INSTITUTION:  - Departement of pathology, Hassan II University Hospital, Fez 30000, Morocco. bennaniamal@gmail.com.

RESUMEN / SUMMARY:  - Primary leiomyosarcomas of the thyroid gland are extremely rare. we report a case of a 72 year-old women with a painful growing mass of the left neck with skin fistula. The patient underwent a lobectomy. The tumor histology showed spindle-shaped cells arranged in interlacing fascicles that expressed desmine and Hcaldesmone, but were negative for cytokeratins and thyroglobulin. Total body CT  scan didnt show any other tumor. The patient died two months after surgery. Primary thyroid leiomyosarcoma may be mistaken for other tumors, such as anaplastic or medullary carcinomas. Therefore, the diagnosis is difficult and requires numerous clinical, radiological, and pathological investigations. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: diagnosticpathology.diagnomx.eu/vs/1917621950869224.



TÍTULO / TITLE:  - Recurrent primary cardiac osteosarcoma: a case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gen Thorac Cardiovasc Surg. 2013 Mar 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11748-013-0236-2

AUTORES / AUTHORS:  - Dell’amore A; Asadi N; Caroli G; Dolci G; Bini A; Stella F

INSTITUCIÓN / INSTITUTION:  - Thoracic Surgery Unit, S.Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna, Italy, dellamore76@libero.it.

RESUMEN / SUMMARY:  - Primary malignant cardiac tumors are very rare. Among malignant tumors, sarcomas  occupy first place. In particular, primary cardiac osteosarcoma is extremely rare. To the best of our knowledge, only 42 cases have been reported worldwide. Cardiac malignant tumors usually require complex operations due to the difficulty in completely removing the tumor with acceptable free surgical margins and because of the proximity to vital structures. The current multimodality treatment strategies for cardiac sarcoma are still suboptimal, and surgery in particular frequently has unsatisfactory results. We report a case of recurrent primary cardiac osteosarcoma in a young male who underwent trans-sternal right pneumonectomy and a wide resection of the left and right atrium followed by reconstruction with heterologous pericardium under extracorporeal circulation. The patient died 6 months after the operation due to local and systemic disease recurrence.



TÍTULO / TITLE:  - Psammomatoid juvenile ossifying fibroma: case study and a review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oral Maxillofac Surg. 2013 Feb 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10006-013-0400-y

AUTORES / AUTHORS:  - Figueiredo LM; de Oliveira TF; Paraguassu GM; de Hollanda Valente RO; da Costa WR; Sarmento VA

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, Federal University of Bahia, Salvador, Bahia, Brazil, leo_m_godoy@hotmail.com.

RESUMEN / SUMMARY:  - BACKGROUND: The group of fibro-osseous lesions from the maxillofacial region is very heterogeneous, but what they all have in common is the substitution of normal bone by fibroblasts with the consequent formation of collagen fibers, as well as substitution by different types of mineralized tissues which may be similar to bone or cement. Within this group of lesions, the juvenile ossifying fibroma is found, considered a rare and recurrent benign fibro-osseous neoplasia. The term juvenile ossifying fibroma has been used in the literature to describe two histopathological variations of conventional ossifying fibroma. These variations are trabecular juvenile ossifying fibroma and psammomatoid juvenile ossifying fibroma. Psammomatoid juvenile ossifying fibroma is an uncommon bone-forming neoplasm with aggressive local growth. Diagnostic of this lesion occurs after the correlation of clinical, imaging, and histopathological findings. Proposed treatments range from enucleation and curettage to resection of the tumor. OBJECTIVES: The present article has as its objectives to report an  uncommon case of a 4-year-old male patient treated by conservative approach and revise the literature on juvenile ossifying fibroma. CONCLUSIONS: Psammomatoid juvenile ossifying fibroma, for its being very uncommon, warrants further investigation in order to establish the best treatment, principally in children,  with a view to minimizing mutilating treatments. In the case examined, a conservative treatment was chosen, where the surgeon established curette and cryotherapy, and the reintegration of the child in his social environment, without relapse during the first year of therapy.



TÍTULO / TITLE:  - The uncovered story of leiomyosarcoma of the cervix: a rare case report and review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Mar 20;2013. pii: bcr2013008616. doi: 10.1136/bcr-2013-008616.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-008616

AUTORES / AUTHORS:  - Dhull AK; C A; Kaushal V; Marwah N

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

RESUMEN / SUMMARY:  - Sarcomas of the uterine cervix are uncommon tumours arising from uterine cervix constituting less than 1% of all cervical malignancies. Leiomyosarcoma of uterine cervix is extremely rare. Combined modality of treatment including surgery, radiotherapy and chemotherapy should be used in these patients to achieve better  survival. We present a rare case of leiomyosarcoma of uterine cervix presented with bleeding per vaginam and bulky cervical mass. Simple hysterectomy was carried out and operative findings revealed a large growth arising from the anterior cervical lip. Diagnosis in this case was made by subjecting the resected specimen to histopathological and immunohistochemical analysis. Postoperatively patient received adjuvant combination chemotherapy (VAC) followed by radiotherapy. Patient is asymptomatic without any evidence of tumour recurrence after 6 months of follow-up.



TÍTULO / TITLE:  - Misdiagnosis of soft tissue sarcomas of the lower limb associated with deep venous thrombosis: report of two cases and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - BMC Musculoskelet Disord. 2013 Feb 19;14:64. doi: 10.1186/1471-2474-14-64.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1471-2474-14-64

AUTORES / AUTHORS:  - Perisano C; Maffulli N; Colelli P; Marzetti E; Panni AS; Maccauro G

INSTITUCIÓN / INSTITUTION:  - Department of Geriatrics, Neurosciences and Orthopedics, University Hospital “Agostino Gemelli”, Catholic University of the Sacred Heart School of Medicine, L,go A, Gemelli 1, 00168, Rome, Italy. carloperisano@hotmail.it.

RESUMEN / SUMMARY:  - BACKGROUND: Deep venous thrombosis (DVT) or pulmonary embolism (PE) is a rare, but not exceptional presentation of soft tissue sarcomas (STSs). Due to the remarkable difference in the incidence between DVT or PE and STSs, this type of STS presentation is usually associated with a considerable delay in tumor diagnosis and treatment. CASE PRESENTATION: We describe two cases of STS who presented with DVT and PE. Physical and radiographic examination only showed the  presence of DVT. Both patients were treated for DVT or PE for several months. Due to the persistence of symptoms and the inefficacy of anticoagulant therapy, magnetic resonance imaging (MRI) was performed, which revealed the presence of a  lower limb mass in both cases. The definite diagnosis was reached via excisional  biopsy and histological examination.In one case, MRI showed a large tumor in the  anterior muscle compartment of the right thigh, with thrombosis of the right common femoral vein and involvement of the ipsilateral common iliac vein and inferior vena cava until the confluence of the renal veins. In the other case, MRI showed a large tumor in the middle third of the right thigh. The lesion was in close proximity to the superficial femoral vein that appeared compressed and showed signs of thrombosis. In both cases, histological examination revealed a high-grade leiomyosarcoma. CONCLUSION: STSs of the lower extremities can rarely present with DVT or PE. This possibility should be considered in the differential diagnosis of painful leg swelling, especially in patients with recurrent or refractory venous thrombosis. When a STS is suspected, MRI should be obtained followed by excisional biopsy of the eventual mass. A delay in diagnosis and treatment of STSs often results in very poor prognosis.Level of evidence. IV.



TÍTULO / TITLE:  - Colon angiolipoma with intussusception: a case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Mar 15;11:69. doi: 10.1186/1477-7819-11-69.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-69

AUTORES / AUTHORS:  - Wang L; Chen P; Zong L; Wang GY; Wang H

INSTITUCIÓN / INSTITUTION:  - Department of Gastrointestinal Surgery, Su Bei People’s Hospital of Jiangsu Province, Yangzhou University, Yangzhou 225001, Jiangsu Province, China. chen86ky@126.com.

RESUMEN / SUMMARY:  - Angiolipomas are frequently observed benign tumors. They have a typical vascular  component and are often located in subcutaneous tissues, and more rarely, in the  gastrointestinal tract. We present the case of a 58-year-old man who complained of abdominal discomfort in the left lower quadrant and two to three bloody stools a day without any obvious etiology. These symptom became more severe in the next  three days, due to a large angiolipoma located in the descending colon, which was diagnosed intraoperatively. In a literature review, we found only 22 cases of angiolipomas involving the gastrointestinal tract which are reported in the literature from 1960 to 2012 in PubMed; the key words used in the search are gastrointestinal tract angiolipoma, esophagus, stomach, duodenum, intestine, ileocecal junction, colon, rectum angiolipomas. Colon angiolipoma with intussusception, as seen in this case, is rare and may require emergent surgical  intervention.



TÍTULO / TITLE:  - Colonic angiolipoma - a rare finding in the gastrointestinal tract. Case report and review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Radiol Case Rep. 2012 Jun;6(6):23-8. doi: 10.3941/jrcr.v6i6.1069. Epub 2012 Jun 1.

            ●● Enlace al texto completo (gratuito o de pago) 3941/jrcr.v6i6.1069

AUTORES / AUTHORS:  - Molinares B; Goldstein A; Varela GJ; Mesa S

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Pablo Tobon Uribe Hospital, Medellin, Colombia. beatrizmolinares@gmail.com

RESUMEN / SUMMARY:  - Angiolipomas are benign lesions that are frequently found in subcutaneous cellular tissue, but are rarely located in the gastrointestinal tract. Here we discuss a case of colonic angiolipoma that presented as a mass near the hepatic flexure, occupying approximately 90% of the colonic lumen. The diagnosis was made by endoscopy and computed tomography. The mass was resected successfully and diagnosis was confirmed by histological studies and immunohistochemical tests.



TÍTULO / TITLE:  - Co-existing of sinonasal inverted papilloma and angiofibroma: case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Inform Med. 2012 Dec;20(4):261-3. doi: 10.5455/aim.2012.20.261-263.

            ●● Enlace al texto completo (gratuito o de pago) 5455/aim.2012.20.261-263

AUTORES / AUTHORS:  - Shahrjerdi B; Angoyaroko A; Abdullah B

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.

RESUMEN / SUMMARY:  - Sinonasal tumors may grow to considerable size before presentation and in view of their relation to the base of skull, orbit, cranial nerves and vital vessels; a precise diagnostic and therapeutic planning is needed to achieve the optimal results. We report a case who presented with unilateral nasal blockage, rhinorrhea and episodes of epistaxis which diagnosed as sinonasal inverted papilloma and angiofibroma.



TÍTULO / TITLE:  - Incidental detection of adrenal myelolipoma: a case report and review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Urol. 2013;2013:789481. doi: 10.1155/2013/789481. Epub 2013 Feb 20.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/789481

AUTORES / AUTHORS:  - Nabi J; Rafiq D; Authoy FN; Sofi GN

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Shaheed Suhrawardy Medical College and Hospital, Dhaka 1207, Bangladesh.

RESUMEN / SUMMARY:  - Introduction. Adrenal myelolipoma is a rare tumor that is benign in nature, usually asymptomatic, unilateral, and nonsecreting. It is composed of variable mixture of mature adipose tissue and hematopoietic elements and develops within the adrenal gland. With the widespread use of cross-sectional imaging modalities  such as ultrasonography and computed tomography, the incidental detection of these tumors is increasing in frequency. Case Presentation. We report a case of adrenal myelolipoma in a 63-year-old Kashmiri male, who presented with pain in the right upper abdomen. Physical examination was unremarkable. Ultrasound abdomen showed the presence of a hyperechoic mass in the right suprarenal region  with undefined margins. Contrast-enhanced computed tomography (CECT) scan of abdomen revealed a well-defined, round lesion in the right suprarenal region with heterogeneous attenuation suggesting the possibility of myelolipoma. The patient  was subjected to right adrenalectomy and his postoperative course was uneventful. The histopathological evaluation of the mass confirmed the initial diagnosis of adrenal myelolipoma. Conclusion. Although mostly discovered as an “incidentaloma”, the diagnosis of adrenal myelolipoma warrants thorough diagnostic study. Imaging techniques such as ultrasonography and CT scans as well as biochemical studies are useful for indicating the best treatment taking into account the size of the mass and possible hormone production. Surgical resection  is advocated through extraperitoneal approach as it minimizes postoperative complications and leads to quicker recovery.



TÍTULO / TITLE:  - Hereditary gingival fibromatosis: a review and a report of a rare case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Dent. 2013;2013:930972. doi: 10.1155/2013/930972. Epub 2013 Feb 21.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/930972

AUTORES / AUTHORS:  - Aghili H; Goldani Moghadam M

INSTITUCIÓN / INSTITUTION:  - Department of Orthodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd 89195/165, Iran.

RESUMEN / SUMMARY:  - Hereditary gingival fibromatosis (HGF) is a rare condition which manifests itself by an enlarged gingival tissue covering teeth to various extents. The condition may occur isolated or as part of a syndrome. This paper presents a case of 9-year-old female patient suffering from HGF with chief complaint of mouth protrusion. Cephalometric findings showed severe mandibular deficiency and vertical maxillary excess. Patient exhibited perioral muscle contraction on mouth closing. After discussing the treatment possibilities with the patient and her parents, the decision was made to wait until growth potential decreases (following the adolescent growth spurt) and to correct the problem with orthognathic surgery.



TÍTULO / TITLE:  - Uterine intravenous leiomyomatosis with cardiac extension: Imaging characteristics and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Clin Oncol. 2013 Feb 10;4(1):25-8. doi: 10.5306/wjco.v4.i1.25.

            ●● Enlace al texto completo (gratuito o de pago) 5306/wjco.v4.i1.25

AUTORES / AUTHORS:  - Xu ZF; Yong F; Chen YY; Pan AZ

INSTITUCIÓN / INSTITUTION:  - Zhi-Feng Xu, Fang Yong, Ying-Yu Chen, Ai-Zhen Pan, Department of Medical Imaging, The First People’s Hospital of Foshan, Foshan 528000, Guangdong Province, China.

RESUMEN / SUMMARY:  - Intravenous leiomyomatosis (IVL), showing unusual growth patterns of uterine leiomyoma, is a rare neoplasm characterized by intravascular proliferation of a histologically benign-looking smooth muscle cell tumor mass, but not invading the tissue. To date, less than 300 cases have been reported and fewer than 100 cases  with cardiac involvement. Imaging characteristics of IVL are still not clear so it is usually misdiagnosed before surgery. A 36-year-old woman, who had undergone hysterectomy due to hysteromyoma, presented with shortness of breath after activities. Imaging showed IVL with mass involvement of the left ovarian vein, left renal vein, left external and common iliac vein, as well as within the inferior vena cava (IVC), extending into the right atrium. The operation demonstrated that the mass had no stalk and had well-demarcated borders with the  wall of the right atrium and IVC. The patient underwent a one-stage combined multidisciplinary thoraco-abdominal operation under general anesthetic. Subsequently, the pathology report confirmed IVL. IVL should be considered in a female patient presenting with an extensive mass in the right side of the heart.  Imaging technology, such as echocardiogram, contrast-enhanced computed tomography and magnetic resonance imaging, can provide important information to reveal the mass, the range and path of the lesion, and relates to the surgical plan decision. Consequently, perfect and exact image examination is very necessary pre-operation.



TÍTULO / TITLE:  - Osteoid osteoma of the distal humerus mimicking sequela of pediatric supracondylar fracture: arthroscopic resection-case report and a literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Med. 2013;2013:247328. doi: 10.1155/2013/247328. Epub 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/247328

AUTORES / AUTHORS:  - Font Segura J; Barrera-Ochoa S; Gargallo-Margarit A; Correa-Vazquez E; Isart-Torruella A; Mir Bullo X

INSTITUCIÓN / INSTITUTION:  - Hand Surgery Unit, Hospital Universitari USP Dexeus, España.

RESUMEN / SUMMARY:  - Osteoid osteoma (OO) is a small and painful benign osteoblastic tumour located preferentially in the shaft of long bones near the metaphyseal junctions, with a  predilection for the lower limbs. Juxta- and intra-articular OOs are rare and even though hip, elbow, and talus are the most commonly reported locations, they  may be found in any joint accounting for approximately 13% of all osteoid osteomas. There is usually a significant time delay between symptom initiation and diagnosis when the lesion is present in an uncommon location due to the diagnostic challenge it presents due to the lack of classical clinical signs and/or radiographic features found in the extra-articular lesions. A case of a distal humerus OO of a 15-year-old girl is presented to point out that a confounding factor, such as a previous paediatric supracondylar fracture, may further delay the already difficult diagnosis of a juxta- or intra-articular osteoid osteoma and also to emphasize the possibility of arthroscopic treatment of such lesions.



TÍTULO / TITLE:  - Rhabdomyosarcomatous differentiation in a spermatocytic seminoma with review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Urol. 2012 Oct;28(4):430-3. doi: 10.4103/0970-1591.105760.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0970-1591.105760

AUTORES / AUTHORS:  - Narang V; Gupta K; Gupta A; Kumar S

INSTITUCIÓN / INSTITUTION:  - Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

RESUMEN / SUMMARY:  - The sarcomatous differentiation occurring in spermatocytic seminoma (SS) renders  an aggressive behavior with metastatic potential to this relatively indolent neoplasm. Correct identification of this sarcomatous component is essential as further management differs. Herein, we report a case of young male with SS with rapid increase in size of the tumor. Histopathology revealed a rhabdomyosarcomatous component infiltrating the rete-testis and epididymis along  with a well-circumscribed SS.



TÍTULO / TITLE:  - American Brachytherapy Society (ABS) consensus statement for sarcoma brachytherapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Brachytherapy. 2013 Feb 20. pii: S1538-4721(13)00198-0. doi: 10.1016/j.brachy.2012.12.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.brachy.2012.12.002

AUTORES / AUTHORS:  - Holloway CL; Delaney TF; Alektiar KM; Devlin PM; O’Farrell DA; Demanes DJ

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, BC Cancer Agency, Vancouver Island Centre, Victoria, BC, Canada. Electronic address: cholloway@bccancer.bc.ca.

RESUMEN / SUMMARY:  - PURPOSE: To present recommendations for the use of brachytherapy (BT) in patients with soft tissue sarcoma (STS). METHODS: A group of practitioners with expertise  and experience in sarcoma BT formulated recommendations for BT in STS based on clinical experience and literature review. RESULTS: The indications for adjuvant  BT are discussed. There is no consensus on the use of BT alone or in combination  with external beam radiation therapy (EBRT), but factors that influence the selection of this modality include tumor grade and size, prior surgeries, and tumor recurrence. Low-dose-rate, high-dose-rate, and pulsed-dose-rate radiation are all acceptable BT modalities to use for STS. Recommendations are made for patient selection, techniques, dose rates, and dosages. Outcome data and toxicity data are reviewed. CONCLUSIONS: BT is a useful component of the treatment of STS. The advantages of BT are the targeted dose distribution, low integral dose, and short treatment times. Ultimately the clinician should select the modality or combination of modalities that are most familiar to the treatment team and suitable to the patient.



TÍTULO / TITLE:  - Lymphangioleiomyomatosis: current and future.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Thorac Dis. 2013 Feb;5(1):74-9. doi: 10.3978/j.issn.2072-1439.2013.01.03.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2072-1439.2013.01.03

AUTORES / AUTHORS:  - Mavroudi M; Zarogoulidis P; Katsikogiannis N; Tsakiridis K; Huang H; Sakkas A; Kallianos A; Rapti A; Sarika E; Karapantzos I; Zarogoulidis K

INSTITUCIÓN / INSTITUTION:  - Pulmonary Department, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;

RESUMEN / SUMMARY:  - Lymphangioleiomyomatosis is a rare slowly progressive lung disease that affects almost exclusively young women of reproductive age. It occurs sporadically or in  association with Tuberous Sclerosis Complex. LAM is characterized by cystic remodeling of the lung parenchyma, due to proliferation of abnormal smooth muscle-like LAM cells and presence of extra pulmonary manifestations such as lymphadenopathy, angiomyolipomas and abdominal lymphangioleiomyomas. The most common clinical manifestations are progressive dyspnea on exertion, pneumothorax  and chylous effusions. Currently there is no curative treatment for the disease,  but the ongoing study of the genetic and molecular pathways implicated in the pathogenesis of the disease could lead to targeted therapy.