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Artículos originales (todos) *** Original articles (all)

Connective and Soft Tissue Tumors.

February - March 2013

 

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[1]

TÍTULO / TITLE:  - Outcome Prediction in Primary Resected Retroperitoneal Soft Tissue Sarcoma: Histology-Specific Overall Survival and Disease-Free Survival Nomograms Built on  Major Sarcoma Center Data Sets.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Mar 25.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.44.3747

AUTORES / AUTHORS:  - Gronchi A; Miceli R; Shurell E; Eilber FC; Eilber FR; Anaya DA; Kattan MW; Honore C; Lev DC; Colombo C; Bonvalot S; Mariani L; Pollock RE

INSTITUCIÓN / INSTITUTION:  - Alessandro Gronchi, Rosalba Miceli, Chiara Colombo, and Luigi Mariani, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy; Elizabeth Shurell, Fritz C. Eilber, and Frederick R. Eilber, University of California at Los Angeles, Los Angeles, CA; Daniel A. Anaya, Baylor College of Medicine; Dina C. Lev and Raphael E. Pollock, Sarcoma Research Center, University of Texas MD Anderson Cancer Center, Houston, TX; Michael W. Kattan, Cleveland Clinic Foundation, Cleveland, OH; and Charles Honore and Sylvie Bonvalot, Institute Gustave Roussy, Villejuif, France.

RESUMEN / SUMMARY:  - PURPOSEIntegration of numerous prognostic variables not included in the conventional staging of retroperitoneal soft tissue sarcomas (RPS) is essential in providing effective treatment. The purpose of this study was to build a specific nomogram for predicting postoperative overall survival (OS) and disease-free survival (DFS) in patients with primary RPS. PATIENTS AND METHODSData registered in three institutional prospective sarcoma databases were  used. We included patients with primary localized RPS resected between 1999 and 2009. Univariate (Kaplan and Meier plots) and multivariate (Cox model) analyses were carried out. The a priori chosen prognostic covariates were age, tumor size, grade, histologic subtype, multifocality, quality of surgery, and radiation therapy. External validation was performed by applying the nomograms to the patients of an external cohort. The model’s discriminative ability was estimated  by means of the bootstrap-corrected Harrell C statistic.ResultsIn all, 523 patients were identified at the three institutions (developing set). At a median  follow-up of 45 months (interquartile range, 22 to 72 months), 171 deaths were recorded. Five- and 7-year OS rates were 56.8% (95% CI, 51.4% to 62.6%) and 46.7% (95% CI, 39.9% to 54.6%. Two hundred twenty-one patients had disease recurrence.  Five- and 7-year DFS rates were 39.4% (95% CI, 34.5% to 45.0%) and 35.7% (95% CI, 30.3% to 42.1%). The validation set consisted of 135 patients who were identified at the fourth institution for external validation. The bootstrap-corrected Harrell C statistics for OS and DFS were 0.74 and 0.71 in the developing set and  0.68 and 0.69 in the validating set. CONCLUSIONThese nomograms accurately predict OS and DFS. They should be used for patient counseling in clinical practice and stratification in clinical trials.

 

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[2]

TÍTULO / TITLE:  - High-Grade KIT-Negative Sarcoma of the Small Bowel in a Patient With Chronic Myeloid Leukemia Receiving Long-Term Tyrosine Kinase Inhibitors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Feb 25.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.42.7989

AUTORES / AUTHORS:  - Martz J; Jain S; Vahdat LT; Qin L; Mosquera JM; Antonescu CR; Popa EC

INSTITUCIÓN / INSTITUTION:  - Ludwig-Maximilians Universitat Munich, Munich, Germany.

 

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[3]

TÍTULO / TITLE:  - Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Lancet Oncol. 2013 Mar 8. pii: S1470-2045(13)70049-4. doi: 10.1016/S1470-2045(13)70049-4.

            ●● Enlace al texto completo (gratuito o de pago) 1016/S1470-2045(13)70049-4

AUTORES / AUTHORS:  - Schwartz GK; Tap WD; Qin LX; Livingston MB; Undevia SD; Chmielowski B; Agulnik M; Schuetze SM; Reed DR; Okuno SH; Ludwig JA; Keedy V; Rietschel P; Kraft AS; Adkins D; Van Tine BA; Brockstein B; Yim V; Bitas C; Abdullah A; Antonescu CR; Condy M; Dickson MA; Vasudeva SD; Ho AL; Doyle LA; Chen HX; Maki RG

INSTITUCIÓN / INSTITUTION:  - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address: schwartg@mskcc.org.

RESUMEN / SUMMARY:  - BACKGROUND: Preclinical studies have shown synergistic antitumour activity by inhibition of insulin-like growth factor-1 receptor (IGF-1R) and mTOR. The expression of IGF-1R seems to be crucial for this effect. We investigated the safety and efficacy of the combination of the IGF-1R antibody cixutumumab and the mTOR inhibitor temsirolimus in patients with chemotherapy-refractory bone and soft-tissue sarcomas according to IGF-1R expression by immunohistochemistry. METHODS: We undertook a multicentre, open-label, phase 2 study in 19 cancer centres in the USA. Patients aged at least 16 years with a histologically confirmed diagnosis of bone or soft-tissue sarcoma were allocated on the basis of IGF-1R expression by immunohistochemistry to one of three treatment groups: IGF-1R-positive soft-tissue sarcoma (group A), IGF-1R-positive bone sarcomas (group B), or IGF-1R-negative bone and soft-tissue sarcoma (group C). Patients received weekly treatment with cixutumumab (6 mg/kg, intravenous) and temsirolimus (25 mg, intravenous flat dose) in 6-week cycles. A Simon optimal two-stage design was used for every arm. The primary endpoint was progression-free survival (PFS) at 12 weeks by intention-to-treat analysis in the first 54 patients assigned to every treatment arm. Although patients still remain on treatment, this trial has completed enrolment and this represents the final analysis. This study is registered with ClinicalTrials.gov, number NCT01016015. FINDINGS: Between Nov 18, 2009, and April 11, 2012, 388 patients were screened for IGF-1R expression and 54 were assigned to each arm. 17 of 54 patients in the  IGF-1R-positive soft-tissue sarcoma group (31%; one-sided 95% CI lower bound 21%; two-sided 90% CI 21-43), 19 of 54 in IGF-1R-positive bone sarcoma group (35%; one-sided 95% CI lower bound 24%; two-sided 90% CI 24-47), and 21 of 54 in the IGF-1R-negative group (39%, one-sided 95% CI lower bound 28%; two-sided 90% CI 28-51) were progression free at 12 weeks. On April 6, 2011, the protocol was amended to include three additional patients in the IGF-1R-positive soft-tissue sarcoma group (total of 57 patients) and nine more in the IGF-1R-negative group (total of 63 patients). There were 2546 adverse events reported during the study, 214 (8%) of which were grade 3-4. The most common grade 3-4 toxicities in the 174 treated patients were anaemia in 16 (9%) patients, hyperglycaemia in 18 (10%), hypophosphataemia in 16 (9%), lymphopenia in 25 (14%), oral mucositis in 19 (11%), and thrombocytopenia in 19 (11%). INTERPRETATION: The combination of cixutumumab and temsirolimus shows clinical activity in patients with sarcoma and forms a basis for future trials. However, IGF-1R expression by immunohistochemistry is not predictive of clinical outcome after treatment with this combination. FUNDING: National Cancer Institute and CycleforSurvival Fund, Memorial Sloan-Kettering Cancer Center.

 

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[4]

TÍTULO / TITLE:  - Adult Ewing Sarcoma: Survival and Local Control Outcomes in 36 Patients With Metastatic Disease.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Clin Oncol. 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1097/COC.0b013e31827de65e

AUTORES / AUTHORS:  - Ahmed SK; Robinson SI; Okuno SH; Rose PS; Issa Laack NN

INSTITUCIÓN / INSTITUTION:  - *Mayo Medical School Divisions of daggerOncology double daggerOrthopedic Surgery  section signRadiation Oncology, Mayo Clinic, Rochester, MN.

RESUMEN / SUMMARY:  - OBJECTIVES:: To assess the clinical features and outcomes in adult patients with  metastatic Ewing sarcoma (ES). METHODS:: The records of 36 ES patients with metastatic disease >/=18 years seen from 1977 to 2007 at the Mayo Clinic were studied retrospectively. Factors relevant to prognosis, survival, and local control (LC) were analyzed. RESULTS:: The 4-year overall survival (OS) and event-free survival (EFS) rates were 20% and 11%, respectively. Patients treated  from 1993 to 2007 had significantly improved outcomes compared with those treated from 1977 to 1992: 4-year OS and EFS of 31% and 16%, respectively, versus 0% (P=0.01). Primary tumor (P=0.005 and 0.04) and metastatic sites (P=0.05) were independent EFS prognostic factors. Four patients (11%) received surgery, 18 (50%) radiation therapy (RT), 4 (11%) surgery+radiation therapy (S+RT), and 10 (28%) received no LC. The 4-year EFS rates were 0% for surgery, 21% for RT, 0% for S+RT, and 0% for no LC (P=0.0001). OS in patients who received vincristine, doxorubicin, and cyclophosphamide alternating with ifosphamide and etoposide (VDC/IE) chemotherapy was improved (P=0.04). Relapses were documented in 18 patients (excluding patients who received no LC). In total, 44% of patients had all of their metastatic site(s) treated. Patients who received treatment to all extrapulmonary metastases had significantly improved outcomes compared with those who did not receive treatment to all sites: 4-year OS and EFS of 33% and 11%, respectively, versus 0% (P=0.04 and 0.02). CONCLUSIONS:: Our results suggest outcomes for adult patients with metastatic ES are similar to pediatric cohorts in the modern era. VDC/IE chemotherapy and treatment to all metastatic lesions is associated with improved outcomes.

 

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[5]

TÍTULO / TITLE:  - Clinical outcomes and safety with trabectedin therapy in patients with advanced soft tissue sarcomas following failure of prior chemotherapy: results of a worldwide expanded access program study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Oncol. 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1093/annonc/mds659

AUTORES / AUTHORS:  - Samuels BL; Chawla S; Patel S; von Mehren M; Hamm J; Kaiser PE; Schuetze S; Li J; Aymes A; Demetri GD

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Kootenai Cancer Center, Post Falls.

RESUMEN / SUMMARY:  - BackgroundThis expanded access program (EAP) was designed to provide trabectedin  access for patients with incurable soft tissue sarcoma (STS) following progression of disease with standard therapy. The outcomes of trial participants  accrued over approximately 5 years are reported.Patients and methodsAdult patients with advanced STS of multiple histologies, including leiomyosarcoma and  liposarcoma (L-sarcomas), following relapse or disease progression following standard-of-care chemotherapy, were enrolled. Trabectedin treatment cycles (1.5 mg/m(2), intravenously over 24 h) were repeated q21 days. Objective response, overall survival (OS), and safety were evaluated.ResultsOf 1895 patients enrolled, 807 (43%) had evaluable objective response data, with stable disease reported in 343 (43%) as best response. L-sarcoma patients exhibited longer, OS compared with other histologies [16.2 months (95% confidence interval (CI) 14.1-19.5) versus 8.4 months (95% CI 7.1-10.7)], and a slightly higher objective  response rate [6.9% (95% CI 4.8-9.6) versus 4.0% (95% CI 2.1-6.8)]. The median treatment duration was 70 days representing a median of three treatment cycles; 30% of patients received >/=6 cycles. Safety and tolerability in this EAP were consistent with prior clinical trial data.ConclusionResults of this EAP are consistent with previous reports of trabectedin, demonstrating disease control despite a low incidence of objective responses in advanced STS patients after failure of standard chemotherapy.ClinicalTrials.govNCT00210665.

 

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[6]

TÍTULO / TITLE:  - Clinical and Genetic Analysis of a Korean Patient with X-linked Chondrodysplasia  Punctata: Identification of a Novel Splicing Mutation in the ARSE Gene.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Clin Lab Sci. 2013 Winter;43(1):70-5.

AUTORES / AUTHORS:  - Jeon GW; Kwon MJ; Lee SJ; Sin JB; Ki CS

INSTITUCIÓN / INSTITUTION:  - Ph.D. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Republic of Korea, 135-710. Tel.: +82-2-3410-2709; fax: +82-2-3410-2719; e-mail:  changski@skku.edu.

RESUMEN / SUMMARY:  - X-linked recessive chondrodysplasia punctata (CDPX1) is a rare congenital disorder of bone and cartilage development, characterized by punctate calcification in areas of endochondral bone formation, leading to stippled epiphyses, severe nasal and midfacial hypoplasia, short stature, and brachytelephalangy. CDPX1 is caused by mutations in the arylsulfatase E (ARSE) gene located on chromosome Xp22.3. Although most affected males have milder symptoms, some have significant medical problems including respiratory compromise and cervical spinal stenosis due to dysplastic vertebrae. Herein, we present the  case of a male infant with the characteristic features of CDPX1 and severe spinal cord compression. Direct sequencing analysis revealed a novel variation (c.430G>A) in the ARSE gene that was thought to be a missense mutation (p.Gly144Arg), but proved to be a novel splicing mutation (r.[430g>a; 430_431ins430+1_430+21) adding seven amino acids between p.Ile143 and p.Gly144 (p.Ile143_Gly-144insSerMetTyrValPheLysSer). This report expands the spectrum of mutations of the ARSE gene and, to the best of our knowledge, is the first clinically and genetically confirmed case of CDPX1 with severe spinal cord compression in Korea.

 

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[7]

TÍTULO / TITLE:  - Correction for Whitehouse et al., Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4428. doi: 10.1073/pnas.1300714110. Epub 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1073/pnas.1300714110

 

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[8]

TÍTULO / TITLE:  - Locoregional Recurrence After Preoperative Radiation Therapy for Retroperitoneal  Sarcoma: Adverse Impact of Multifocal Disease and Potential Implications of Dose  Escalation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Surg Oncol. 2013 Feb 8.

            ●● Enlace al texto completo (gratuito o de pago) 1245/s10434-013-2868-y

AUTORES / AUTHORS:  - McBride SM; Raut CP; Lapidus M; Devlin PM; Marcus KJ; Bertagnolli M; George S; Baldini EH

INSTITUCIÓN / INSTITUTION:  - Harvard Radiation Oncology Program, Boston, MA, USA, smmcbride@partners.org.

RESUMEN / SUMMARY:  - BACKGROUND: Locoregional recurrence (LRR) rates following preoperative radiation  therapy (RT) and radical resection for retroperitoneal sarcoma (RPS) are high. Targeted radiation dose escalation has been proposed as a means to decrease LRR,  but is applicable only if LRRs are confined to within the RT field. We analyzed predictors for LRR and examined LRR locations to determine the potential benefit  of dose escalation. METHODS: For 33 patients treated with preoperative RT and radical resection, we determined high-risk tumor volumes appropriate for boost and identified the number of recurrences within this volume. Clinical and pathologic variables predictive of overall survival (OS), freedom from progression (FFP), LRR, and distant recurrence (DR) were evaluated. RESULTS: Median follow-up was 32.9 months. At 1 and 3 years, OS was 87 and 64 %, FFP rates were 71 and 45 %, cumulative incidences of LRR were 19 and 37 %, and of DR were 13 and 21 %. On multivariate analysis, multifocal disease was a significant predictor of increased incidence of LRR. At first relapse, 6 patients had isolated LR, 2 isolated RR, 6 isolated DR, 1 synchronous LR and RR, and 1 synchronous LR, RR, and DR. Ultimately, 4 patients (25 % of those who recurred) had isolated in-field recurrences within the hypothetical high-risk dose-painting boost volumes and that thus might have been prevented with dose-escalation. CONCLUSION: Following preoperative RT and resection, LRR rates are high and associated with multifocal disease. Preoperative dose escalation to high-risk tumor volumes may perhaps benefit only a limited subset of patients, and therefore strategies are needed to select appropriate patients for consideration  of this approach.

 

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[9]

TÍTULO / TITLE:  - IQGAP1 suppresses TbetaRII-mediated myofibroblastic activation and metastatic growth in liver.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Invest. 2013 Mar 1;123(3):1138-56. doi: 10.1172/JCI63836. Epub 2013 Feb 1.

            ●● Enlace al texto completo (gratuito o de pago) 1172/JCI63836

AUTORES / AUTHORS:  - Liu C; Billadeau DD; Abdelhakim H; Leof E; Kaibuchi K; Bernabeu C; Bloom GS; Yang L; Boardman L; Shah VH; Kang N

RESUMEN / SUMMARY:  - In the tumor microenvironment, TGF-beta induces transdifferentiation of quiescent pericytes and related stromal cells into myofibroblasts that promote tumor growth and metastasis. The mechanisms governing myofibroblastic activation remain poorly understood, and its role in the tumor microenvironment has not been explored. Here, we demonstrate that IQ motif containing GTPase activating protein 1 (IQGAP1) binds to TGF-beta receptor II (TbetaRII) and suppresses TbetaRII-mediated signaling in pericytes to prevent myofibroblastic differentiation in the tumor microenvironment. We found that TGF-beta1 recruited  IQGAP1 to TbetaRII in hepatic stellate cells (HSCs), the resident liver pericytes. Iqgap1 knockdown inhibited the targeting of the E3 ubiquitin ligase SMAD ubiquitination regulatory factor 1 (SMURF1) to the plasma membrane and TbetaRII ubiquitination and degradation. Thus, Iqgap1 knockdown stabilized TbetaRII and potentiated TGF-beta1 transdifferentiation of pericytes into myofibroblasts in vitro. Iqgap1 deficiency in HSCs promoted myofibroblast activation, tumor implantation, and metastatic growth in mice via upregulation of paracrine signaling molecules. Additionally, we found that IQGAP1 expression was  downregulated in myofibroblasts associated with human colorectal liver metastases. Taken together, our studies demonstrate that IQGAP1 in the tumor microenvironment suppresses TbetaRII and TGF-beta dependent myofibroblastic differentiation to constrain tumor growth.

 

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[10]

TÍTULO / TITLE:  - Magnetic Resonance Imaging-Guided Focused Ultrasound Treatment of Symptomatic Uterine Fibroids: Impact of Technology Advancement on Ablation Volumes in 115 Patients.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Invest Radiol. 2013 Feb 4.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLI.0b013e3182806904

AUTORES / AUTHORS:  - Trumm CG; Stahl R; Clevert DA; Herzog P; Mindjuk I; Kornprobst S; Schwarz C; Hoffmann RT; Reiser MF; Matzko M

INSTITUCIÓN / INSTITUTION:  - From the *Department of Clinical Radiology, Klinikum der Ludwig-Maximilians-Universitat Munchen-Grosshadern, Munchen; daggerDepartment of  Diagnostic and Interventional Radiology, Klinikum Dachau, Dachau; and double daggerDepartment and Policlinics of Diagnostic Radiology, Universitatsklinikum Carl Gustav Carus Dresden, Dresden, Germany.

RESUMEN / SUMMARY:  - OBJECTIVES: The aim of this study was to assess the impact of the advanced technology of the new ExAblate 2100 system (Insightec Ltd, Haifa, Israel) for magnetic resonance imaging (MRI)-guided focused ultrasound surgery on treatment outcomes in patients with symptomatic uterine fibroids, as measured by the nonperfused volume ratio. MATERIALS AND METHODS: This is a retrospective analysis of 115 women (mean age, 42 years; range, 27-54 years) with symptomatic fibroids who consecutively underwent MRI-guided focused ultrasound treatment in a single center with the new generation ExAblate 2100 system from November 2010 to June 2011. Mean +/- SD total volume and number of treated fibroids (per patient) were  89 +/- 94 cm and 2.2 +/- 1.7, respectively. Patient baseline characteristics were analyzed regarding their impact on the resulting nonperfused volume ratio. RESULTS: Magnetic resonance imaging-guided focused ultrasound treatment was technically successful in 115 of 123 patients (93.5%). In 8 patients, treatment was not possible because of bowel loops in the beam pathway that could not be mitigated (n = 6), patient movement (n = 1), and system malfunction (n = 1). Mean nonperfused volume ratio was 88% +/- 15% (range, 38%-100%). Mean applied energy level was 5400 +/- 1200 J, and mean number of sonications was 74 +/- 27. No major complications occurred. Two cases of first-degree skin burn resolved within 1 week after the intervention. Of the baseline characteristics analyzed, only the planned treatment volume had a statistically significant impact on nonperfused volume ratio. CONCLUSIONS: With technological advancement, the outcome of MRI-guided focused ultrasound treatment in terms of the nonperfused volume ratio  can be enhanced with a high safety profile, markedly exceeding results reported in previous clinical trials.

 

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[11]

TÍTULO / TITLE:  - Uterine leiomyoma: available medical treatments and new possible therapeutic options.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Endocrinol Metab. 2013 Mar;98(3):921-34. doi: 10.1210/jc.2012-3237. Epub 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1210/jc.2012-3237

AUTORES / AUTHORS:  - Islam MS; Protic O; Giannubilo SR; Toti P; Tranquilli AL; Petraglia F; Castellucci M; Ciarmela P

INSTITUCIÓN / INSTITUTION:  - PhD, Department of Experimental and Clinical Medicine, Faculty of Medicine, Polytechnic University of Marche, via Tronto 10/a, 60020 Ancona, Italy. p.ciarmela@univpm.it.

RESUMEN / SUMMARY:  - Context: Uterine leiomyomas (fibroids or myomas) are benign tumors of the uterus  and are clinically apparent in up to 25% of reproductive-age women. Heavy or abnormal uterine bleeding, pelvic pain or pressure, infertility, and recurrent pregnancy loss are generally associated with leiomyoma. Although surgical and radiological therapies are frequently used for the management of this tumor, medical therapies are considered the first-line treatment of leiomyoma. Evidence  Acquisition and Synthesis: A review was conducted of electronic and print data comprising both original and review articles on pathophysiology and medical treatments of uterine leiomyoma retrieved from the PubMed or Google Scholar database up to June 2012. These resources were integrated with the authors’ knowledge of the field. Conclusion: To date, several pathogenetic factors such as genetic factors, epigenetic factors, estrogens, progesterone, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in leiomyoma development and growth. On the basis of current hypotheses, several  medical therapies have been investigated. GnRH agonist has been approved by US Food and Drug Administration for reducing fibroid volume and related symptoms. In addition, the FDA also approved an intrauterine device, levonorgestrel-releasing  intrauterine system (Mirena), for additional use to treat heavy menstrual bleeding in intrauterine device users only. Currently, mifepristone, asoprisnil,  ulipristal acetate, and epigallocatechin gallate have been shown to be effective  for fibroid regression and symptomatic improvement which are all in clinical trial. In addition, some synthetic and natural compounds as well as growth factor inhibitors are now under laboratory investigation, and they could serve as future therapeutic options.

 

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[12]

TÍTULO / TITLE:  - Clinical Outcomes of Adult Patients With Relapsed Ewing Sarcoma: A 30-Year Single-Institution Experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Clin Oncol. 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 1097/COC.0b013e318281d6ab

AUTORES / AUTHORS:  - Robinson SI; Ahmed SK; Okuno SH; Arndt CA; Rose PS; Laack NN

INSTITUCIÓN / INSTITUTION:  - Divisions of *Medical Oncology double daggerPediatric Hematology and Oncology section signOrthopedic Oncology Departments of paragraph signRadiation Oncology parallelOrthopedic Surgery daggerMayo Medical School, College of Medicine, Mayo Clinic, Rochester, MN.

RESUMEN / SUMMARY:  - OBJECTIVES:: We aimed to determine the prognostic factors that influence the outcome of adult patients who have disease relapse after treatment for localized  Ewing sarcoma. METHODS:: We retrospectively searched for the records of patients  aged 18 years and older with localized Ewing sarcoma at Mayo Clinic, Rochester, Minnesota, from 1977 to 2007, who had disease relapse after initial treatment. Patient records were reviewed to analyze factors affecting survival. RESULTS:: A  total of 49 patients were identified. The 5-year postrelapse survival rate was 30%. Significant factors affecting the 5-year postrelapse survival rate included  site of initial relapse (local vs. distant, 55% vs. 22%, P=0.045); time to relapse (<2 vs. >/=2 y from original diagnosis, 12% vs. 50%, P=0.003); and second remission with complete surgical resection versus definitive radiotherapy to the  recurrent disease (48% vs. 13%, P<0.001). None of these factors were significant  on multivariate modeling. CONCLUSIONS:: Adult patients with Ewing sarcoma who have disease relapse after primary treatment of localized disease will continue to have recurrences regardless of the modality of salvage therapy. Those that have relapse locally or >2 years after the initial diagnosis and are able to achieve a second remission with definitive surgical or radiation therapy have better survival than those who have disease relapse distantly or before the 2-year time point.

 

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[13]

TÍTULO / TITLE:  - Sentinel node biopsy in soft tissue sarcoma subtypes with a high propensity for regional lymphatic spread—results of a large prospective trial.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Oncol. 2013 Jan 31.

            ●● Enlace al texto completo (gratuito o de pago) 1093/annonc/mds650

AUTORES / AUTHORS:  - Andreou D; Boldt H; Werner M; Hamann C; Pink D; Tunn PU

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Oncology, Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Berlin.

RESUMEN / SUMMARY:  - BackgroundThe role of sentinel lymph node biopsy (SLNB) in soft tissue sarcoma patients has yet to be determined. We sought to evaluate the role of SLNB in the  treatment of patients with clear cell sarcoma (CCS), synovial sarcoma (SS), epithelioid sarcoma (ES) and rhabdomyosarcoma (RMS).Patients and methodsSixty-two consecutive patients without history of regional lymphatic spread or evidence of  distant metastases underwent SLNB.ResultsPositive sentinel nodes were identified  in 2 out of 42 patients with SS and in 6 out of 12 patients with CCS. Only two CCS patients had further metastatic nodes in regional dissection. Both of these patients, along with another CCS patient, developed distant metastases and ultimately died of disease. The remaining three CCS patients are disease-free in  follow-up. One patient with SS and another with ES developed regional lymph node  metastases following a negative SLNB, while a further patient with RMS developed  distant metastases followed by a local recurrence with regional metastases shortly after.ConclusionsSLNB is an important diagnostic tool for patients with CCS, who appear to have a high rate of clinically occult regional lymph node metastases at diagnosis. For SS patients, SLNB appears to be of very little relevance.

 

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[14]

TÍTULO / TITLE:  - Neoadjuvant and adjuvant chemotherapy with high-dose ifosfamide, doxorubicin, cisplatin and high-dose methotrexate in non-metastatic osteosarcoma of the extremities: a phase II trial in Japan.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Chemother. 2013 Feb;25(1):41-8. doi: 10.1179/1973947812Y.0000000055.

            ●● Enlace al texto completo (gratuito o de pago) 1179/1973947812Y.0000000055

AUTORES / AUTHORS:  - Kudawara I; Aoki Y; Ueda T; Araki N; Naka N; Nakanishi H; Matsumine A; Ieguchi M; Mori S; Myoui A; Kuratsu S; Hashimoto N; Yoshikawa H

INSTITUCIÓN / INSTITUTION:  - Osaka National Hospital, Osaka, Japan. kudawara@onh.go.jp

RESUMEN / SUMMARY:  - From 1997 to 2003, 40 patients (all <40 years of age) with non-metastatic osteosarcoma of the extremities were treated with OOS-D and definitive surgery. Two cycles of doxorubicin 90 mg/m(2) plus cisplatin 120 mg/m(2) and ifosfamide 15 g/m(2) were given as neoadjuvant chemotherapy, and two cycles of doxorubicin/cisplatin and ifosfamide, and two cycles of high-dose methotrexate (10-12 g/m(2)) were given post-operatively. All patients underwent limb salvage surgeries, and 66% showed good response to neoadjuvant chemotherapy. With a median follow-up period of 117 months, 31 of the evaluable 40 patients were continuously disease-free, 7 were currently alive with no evidence of disease, and 2 died of disease. There was no local recurrence. The 5-year event-free and overall survival rates were 83 and 98%, respectively. The 10-year event-free and  overall survival rates were 80 and 95%, respectively. The major form of toxicity  was haematological one.

 

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[15]

TÍTULO / TITLE:  - High-throughput tyrosine kinase activity profiling identifies FAK as a candidate  therapeutic target in Ewing sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Res. 2013 Mar 27.

            ●● Enlace al texto completo (gratuito o de pago) 1158/0008-5472.CAN-12-1944

AUTORES / AUTHORS:  - Crompton BD; Carlton AL; Thorner AR; Christie AL; Du J; Calicchio ML; Rivera MN; Fleming MD; Kohl NE; Kung AL; Stegmaier K

INSTITUCIÓN / INSTITUTION:  - Pediatric Oncology, Dana-Farber Cancer Institute.

RESUMEN / SUMMARY:  - Limited progress has been made in the treatment of advanced-stage pediatric solid tumors despite the accelerated pace of cancer discovery over the last decade. Tyrosine kinase inhibition is one tractable therapeutic modality for treating human malignancy. However, little is known about the kinases critical to the development or maintenance of many pediatric solid tumors, such as Ewing sarcoma. Utilizing a fluorescent, bead-based technology to profile activated tyrosine kinases, we identified focal adhesion kinase (FAK, PTK2) as a candidate target in Ewing sarcoma. FAK is a tyrosine kinase critical for cellular adhesion, growth, and survival. As such, it is a compelling target for cancer-based therapy. In this study, we have demonstrated that FAK is highly phosphorylated in primary Ewing sarcoma tumor samples and that downregulation of FAK by shRNA and treatment with a FAK-selective kinase inhibitor, PF-562271, impaired growth and colony formation in Ewing sarcoma cell lines. Moreover, treatment of Ewing sarcoma cell  lines with PF-562271 induced apoptosis and led to downregulation of AKT/mTOR and  CAS activity. Finally, we demonstrated that small-molecule inhibition of FAK attenuated Ewing sarcoma tumor growth in vivo. With FAK inhibitors currently in early-phase clinical trials for adult malignancies, these findings may bear immediate relevance to patients with Ewing sarcoma.

 

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[16]

TÍTULO / TITLE:  - Advanced soft-tissue sarcoma in elderly patients: patterns of care and survival.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Oncol. 2013 Mar 13.

            ●● Enlace al texto completo (gratuito o de pago) 1093/annonc/mdt059

AUTORES / AUTHORS:  - Garbay D; Maki RG; Blay JY; Isambert N; Piperno Neumann S; Blay C; Zanardi E; Boudou-Rouquette P; Bozec L; Duffaud F; Bertucci F; Italiano A

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Institut Bergonie, Bordeaux, France.

RESUMEN / SUMMARY:  - BackgroundThere are no data regarding the management of advanced soft-tissue sarcoma (STS) in elderly patients.Patients and methodsWe retrospectively reviewed the charts of patients >/=75 years old diagnosed with metastatic or unresectable  STS between 1991 and 2011 in 11 French and American centers.ResultsThe study included 361 patients. Of these, 223 patients (62%) received systemic therapy, whereas 123 patients (34%) were managed with best supportive care (BSC) only. Patients who received BSC were more likely to be >/=80 years, with performance status (PS) >/= 2, Charlson comorbidity score >/= 10, and metastatic disease. The median progression-free survival of patients treated with systemic therapy was 4  months (95% CI: 2.9-5.1). Thirty-six patients (16%) stopped chemotherapy because  of toxicity. Median overall survival (OS) of patients managed with specific therapy was 10.9 months (95% CI: 8.3-13.5) versus 5.3 months (95% CI: 3.6-7.1) for patients managed with BSC (P = 0.001). On multivariate analysis, age >/= 80 years, PS >/= 2, and number of metastatic sites were the only independent factors associated with OS.ConclusionA high proportion of elderly patients with advanced  STS were denied chemotherapy. Further efforts are needed to define better the optimal care for fit and unfit elderly patients with STS.

 

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[17]

TÍTULO / TITLE:  - Denosumab Treatment of Metastatic Giant-Cell Tumor of Bone in a 10-Year-Old Girl.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Mar 18.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.46.4255

AUTORES / AUTHORS:  - Karras NA; Polgreen LE; Ogilvie C; Manivel JC; Skubitz KM; Lipsitz E

INSTITUCIÓN / INSTITUTION:  - City of Hope National Medical Center, Duarte, CA.

 

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[18]

TÍTULO / TITLE:  - Immunosenescence is associated with presence of Kaposi’s sarcoma in antiretroviral treated human immunodeficiency virus infection.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - AIDS. 2013 Feb 21.

            ●● Enlace al texto completo (gratuito o de pago) 1097/QAD.0b013e3283601144

AUTORES / AUTHORS:  - Unemori PA; Leslie KS; Hunt PW; Sinclair E; Epling L; Mitsuyasu R; Effros RB; Dock J; Dollard SG; Deeks SG; Martin JN; Maurer TS

INSTITUCIÓN / INSTITUTION:  - aDermatology, University of California, San Francisco, San Francisco, CA, United  States bInternal Medicine, University of California, San Francisco, San Francisco, CA, United States cCenter for AIDS Research Core Immunology Lab, University of California, San Francisco, San Francisco, CA, United States dDepartment of Pathology & Laboratory Medicine, David Geffen School of Medicine,  University of California, Los Angeles, CA, United States eCenters for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Atlanta, Georgia, USA fDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States.

RESUMEN / SUMMARY:  - OBJECTIVE:: Some antiretroviral-treated HIV-infected patients develop Kaposi’s sarcoma (KS) despite long-term suppression of HIV replication. These KS lesions are consistent with KS observed in the elderly uninfected population (“classical  KS”). We investigated potential mechanisms for this phenomenon, focusing on measures of immune activation and T cell senescence. DESIGN:: We compared markers of immunosenescence, naive T cells, activation, and inflammation in CD4+ and CD8+ T cells from antiretroviral-treated subjects with new onset KS (“cases”, n = 19)  and from treated subjects without KS (“controls”, n = 47). RESULTS:: There was increased frequency of CD4+ and CD8+ T cells with an immunosenescence phenotype (CD57+ and CD28-) in cases vs. controls (CD4+T cells: CD57+ 7.4% vs. 3.7%, p = 0.025; CD28- 9.1% vs. 4.8%, p = 0.025; CD8+ T cells: CD57+ 41.5% vs. 27.7%, p = 0.003; CD28- 60.5% vs. 51.3%, p = 0.041). Cases had lower proportions of naive T  cells (CD27+CD28+CD45RA+) in CD4+ (23.0% vs. 32.2%, p = 0.023) and CD8+ (11.3% vs. 20.7%, p < 0.001) T cell compartments. CCR5 was more highly expressed in CD4+ (16.3% vs. 11.0%, p = 0.025), and CD8+ (43.1% vs. 28.3%, p < 0.001) T cell compartments in cases vs. controls. There was no difference in telomere length or telomerase activity in PBMCs, or in T cell expression of activation markers (HLADR+CD38+). CONCLUSIONS:: Among antiretroviral-treated subjects, increased frequencies of T cells with an immunosenescence phenotype and lower frequencies of naive T cells were associated with presence of KS among effectively treated subjects. These data suggest that certain immunologic perturbations-including those associated with aging-might be causally associated with development of KS.

 

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[19]

TÍTULO / TITLE:  - Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3501-6. doi: 10.1073/pnas.1222893110. Epub 2013 Feb 4.

            ●● Enlace al texto completo (gratuito o de pago) 1073/pnas.1222893110

AUTORES / AUTHORS:  - Edris B; Willingham SB; Weiskopf K; Volkmer AK; Volkmer JP; Muhlenberg T; Montgomery KD; Contreras-Trujillo H; Czechowicz A; Fletcher JA; West RB; Weissman IL; van de Rijn M

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Stanford University Medical Center, Stanford, CA 94305.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract and arises from the interstitial cells of Cajal. It is characterized by expression of the receptor tyrosine kinase CD117 (KIT). In 70-80% of GIST cases, oncogenic mutations in KIT are present, leading to constitutive activation of the receptor, which drives the proliferation of these  tumors. Treatment of GIST with imatinib, a small-molecule tyrosine kinase inhibitor, inhibits KIT-mediated signaling and initially results in disease control in 70-85% of patients with KIT-positive GIST. However, the vast majority  of patients eventually develop resistance to imatinib treatment, leading to disease progression and posing a significant challenge in the clinical management of these tumors. Here, we show that an anti-KIT monoclonal antibody (mAb), SR1, is able to slow the growth of three human GIST cell lines in vitro. Importantly,  these reductions in cell growth were equivalent between imatinib-resistant and imatinib-sensitive GIST cell lines. Treatment of GIST cell lines with SR1 reduces cell-surface KIT expression, suggesting that mAb-induced KIT down-regulation may  be a mechanism by which SR1 inhibits GIST growth. Furthermore, we also show that  SR1 treatment enhances phagocytosis of GIST cells by macrophages, indicating that treatment with SR1 may enhance immune cell-mediated tumor clearance. Finally, using two xenotransplantation models of imatinib-sensitive and imatinib-resistant GIST, we demonstrate that SR1 is able to strongly inhibit tumor growth in vivo. These results suggest that treatment with mAbs targeting KIT may represent an alternative, or complementary, approach for treating GIST.

 

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[20]

TÍTULO / TITLE:  - Kaposi’s Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Apr;87(8):4417-31. doi: 10.1128/JVI.03282-12. Epub 2013 Feb 6.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.03282-12

AUTORES / AUTHORS:  - Singh VV; Kerur N; Bottero V; Dutta S; Chakraborty S; Ansari MA; Paudel N; Chikoti L; Chandran B

INSTITUCIÓN / INSTITUTION:  - H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and  Science, North Chicago, Illinois, USA.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma-associated herpesvirus (KSHV) infections of endothelial and B cells are etiologically linked with Kaposi’s sarcoma (KS) and primary effusion B-cell lymphoma (PEL), respectively. KS endothelial and PEL B cells carry multiple copies of the nuclear episomal latent KSHV genome and secrete a variety  of inflammatory cytokines, including interleukin-1beta (IL-1beta) and IL-18. The  maturation of IL-1beta and IL-18 depends upon active caspase-1, which is regulated by a multiprotein inflammasome complex induced by sensing of danger signals. During primary KSHV infection of endothelial cells, acting as a nuclear  pattern recognition receptor, gamma interferon-inducible protein 16 (IFI16) colocalized with the KSHV genome in the nuclei and interacted with ASC and procaspase-1 to form a functional inflammasome (Kerur N et al., Cell Host Microbe 9:363-375, 2011). Here, we demonstrate that endothelial telomerase-immortalized human umbilical cells (TIVE) supporting KSHV stable latency (TIVE-LTC cells) and  PEL (cavity-based B-cell lymphoma 1 [BCBL-1]) cells show evidence of inflammasome activation, such as the activation of caspase-1 and cleavage of pro-IL-1beta and  pro-IL-18. Interaction of ASC with IFI16 but not with AIM2 or NOD-like receptor P3 (NLRP3) was detected. The KSHV latency-associated viral FLIP (vFLIP) gene induced the expression of IL-1beta, IL-18, and caspase-1 mRNAs in an NF-kappaB-dependent manner. IFI16 and cleaved IL-1beta were detected in the exosomes released from BCBL-1 cells. Exosomal release could be a KSHV-mediated strategy to subvert IL-1beta functions. In fluorescent in situ hybridization analyses, IFI16 colocalized with multiple copies of the KSHV genome in BCBL-1 cells. IFI16 colocalization with ASC was also detected in lung PEL sections from  patients. Taken together, these findings demonstrated the constant sensing of the latent KSHV genome by IFI16-mediated innate defense and unraveled a potential mechanism of inflammation induction associated with KS and PEL lesions.

 

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[21]

TÍTULO / TITLE:  - A dose-finding study of temsirolimus and liposomal doxorubicin for patients with  recurrent and refractory bone and soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Cancer. 2013 Feb 5. doi: 10.1002/ijc.28083.

            ●● Enlace al texto completo (gratuito o de pago) 1002/ijc.28083

AUTORES / AUTHORS:  - Thornton KA; Chen AR; Trucco MM; Shah P; Wilky BA; Gul N; Carrera-Haro MA; Ferreira MF; Shafique U; Powell JD; Meyer CF; Loeb DM

INSTITUCIÓN / INSTITUTION:  - Division of Medical Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD.

RESUMEN / SUMMARY:  - There are few effective therapies for high-risk sarcomas. Initial chemosensitivity is often followed by relapse. In vitro, mammalian target of rapamycin (mTOR) inhibition potentiates the efficacy of chemotherapy on resistant sarcoma cells. Although sarcoma trials using mTOR inhibitors have been disappointing, these drugs were used as maintenance. We conducted a Phase I/II clinical trial to test the ability of temsirolimus to potentiate the cytotoxic effect of liposomal doxorubicin and present here the dose-finding portion of this study. Adult and pediatric patients with recurrent or refractory sarcomas were treated with increasing doses of liposomal doxorubicin and temsirolimus using a continual reassessment method for escalation, targeting a dose-limiting toxicity  rate of 20%. Blood samples were drawn before and after the first dose of temsirolimus in Cycles 1 and 2 for pharmacokinetic analysis. The maximally tolerated dose combination was liposomal doxorubicin 30 mg/m2 monthly with temsirolimus 20 mg/m2 weekly. Hematologic toxicity was common but manageable. Dose-limiting toxicities were primarily renal. Concurrent administration of liposomal doxorubicin resulted in increased exposure to sirolimus, the active metabolite of temsirolimus. Thus, the combination of liposomal doxorubicin and temsirolimus is safe for heavily pretreated sarcoma patients. Co-administration with liposomal doxorubicin did not alter temsirolimus pharmacokinetics, but increased exposure to its active metabolite.

 

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[22]

TÍTULO / TITLE:  - Lenograstim in preventing chemotherapy-induced febrile neutropenia in patients with soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anticancer Res. 2013 Feb;33(2):679-84.

AUTORES / AUTHORS:  - Badalamenti G; Incorvaia L; Provenzano S; Bronte G; Leto G; Fulfaro F; Maltese G

INSTITUCIÓN / INSTITUTION:  - Department of Surgical and Oncological Sciences, Via del Vespro 129, 90127 Palermo, Italy. giuseppe.badalamenti@unipa.it

RESUMEN / SUMMARY:  - BACKGROUND: Neutropenia and its complications represent one of the principal dose-limiting toxicity issues in chemotherapeutic regimens for soft tissue sarcoma. Prophylactic granulocyte colony-stimulating factor (G-CSF) reduces the risk of febrile neutropenia (FN). The correct timing of G-CSF administration should be considered in order to optimize the prophylactic treatment. PATIENTS AND METHODS: Patients (>/=18 years old) affected by soft tissue sarcoma and treated with epirubicin and ifosfamide, underwent prophylactic treatment with G-CSF (lenograstim at 263 mug) from day 5 to day 9. The proportion of patients experiencing FN and G4 neutropenia was considered. RESULTS: A total of 36 patients receiving three cycles of chemotherapy with epirubicin plus ifosfamide were treated. None developed FN; G4 neutropenia was reported in 17% of patients.  No treatment delay or dose reduction was required, no antibiotic therapy was administered and no hospitalization occurred. CONCLUSION: Five-day lenograstim treatment is efficient as prophylaxis of FN for soft tissue sarcoma chemotherapy  regimens and allows maintenance of chemotherapy dose intensity.

 

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[23]

TÍTULO / TITLE:  - JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic  differentiation of rhabdomyosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncogene. 2013 Feb 25. doi: 10.1038/onc.2013.46.

            ●● Enlace al texto completo (gratuito o de pago) 1038/onc.2013.46

AUTORES / AUTHORS:  - Walters ZS; Villarejo-Balcells B; Olmos D; Buist TW; Missiaglia E; Allen R; Al-Lazikani B; Garrett MD; Blagg J; Shipley J

INSTITUCIÓN / INSTITUTION:  - Sarcoma Molecular Pathology Team, Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, London, UK.

RESUMEN / SUMMARY:  - Rhabdomyosarcomas (RMS) are the most frequent soft-tissue sarcoma in children and characteristically show features of developing skeletal muscle. The alveolar subtype is frequently associated with a PAX3-FOXO1 fusion protein that is known to contribute to the undifferentiated myogenic phenotype of RMS cells. Histone methylation of lysine residues controls developmental processes in both normal and malignant cell contexts. Here we show that JARID2, which encodes a protein known to recruit various complexes with histone-methylating activity to their target genes, is significantly overexpressed in RMS with PAX3-FOXO1 compared with the fusion gene-negative RMS (t-test; P<0.0001). Multivariate analyses showed that higher JARID2 levels are also associated with metastases at diagnosis, independent of fusion gene status and RMS subtype (n=120; P=0.039). JARID2 levels were altered by silencing or overexpressing PAX3-FOXO1 in RMS cell lines with and without the fusion gene, respectively. Consistent with this, we demonstrated that JARID2 is a direct transcriptional target of the PAX3-FOXO1 fusion protein. Silencing JARID2 resulted in reduced cell proliferation coupled with myogenic differentiation, including increased expression of Myogenin (MYOG) and Myosin Light Chain (MYL1) in RMS cell lines representative of both the alveolar and embryonal subtypes. Induced myogenic differentiation was associated with a decrease in JARID2 levels and this phenotype could be rescued by overexpressing JARID2. Furthermore, we that showed JARID2 binds to and alters the methylation status of histone H3 lysine 27 in the promoter regions of MYOG and MYL1 and that  the interaction of JARID2 at these promoters is dependent on EED, a core component of the polycomb repressive complex 2 (PRC2). Therefore, JARID2 is a downstream effector of PAX3-FOXO1 that maintains an undifferentiated myogenic phenotype that is characteristic of RMS. JARID2 and other components of PRC2 may  represent novel therapeutic targets for treating RMS patients.Oncogene advance online publication, 25 February 2013; doi:10.1038/onc.2013.46.

 

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[24]

TÍTULO / TITLE:  - The effect of high-intensity focused ultrasound treatment on immune function in patients with uterine fibroids.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Hyperthermia. 2013 Mar 28.

            ●● Enlace al texto completo (gratuito o de pago) 3109/02656736.2013.775672

AUTORES / AUTHORS:  - Wang X; Qin J; Chen J; Wang L; Chen W; Tang L

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology, First Affiliated Hospital, Chongqing Medical University , Chongqing .

RESUMEN / SUMMARY:  - Abstract Purpose: The aim of this study was to investigate the effect of high-intensity focused ultrasound (HIFU) on immune function in patients with uterine fibroids, in a randomised comparison to conventional myomectomy. Methods: The patients were assigned (1:1) to the HIFU group or the myomectomy (MY) group.  Venous blood samples were collected 24 h before and 24 h and 72 h after operation. The percentages of CD4+ and CD8+ T cells and natural killer (NK) cells were quantified by flow cytometry (FCM). Serum levels of interleukin-2 (IL-2), IL-6 and IL-10 were determined using enzyme-linked immunosorbent assay. Results:  HIFU was associated with early ambulation, fewer post-operative complications, and shorter hospital stay (p < 0.001). The percentages of CD4+ and CD8+ T cells and NK cells in the HIFU group were not significantly altered after treatment compared with before treatment. In contrast, the numbers of these cells in the MY group decreased significantly 24 h after conventional myomectomy (p < 0.001). The CD4+/CD8+ T cell ratios were also decreased significantly 24 h and 72 h after conventional myomectomy (p < 0.001). Serum levels of IL-6 and IL-10 increased after treatment in both groups. Peak IL-6 and IL-10 levels were significantly lower in the HIFU group than in the MY group (p < 0.001). In contrast, IL-2 level decreased significantly in the MY group compared to the HIFU group at 24 h post-operation (p < 0.001). Conclusions: Short-term post-operative immune function is better preserved after HIFU treatment. Better preserved immune function may reflect a reduction in tissue trauma after HIFU treatment and contribute to reduced post-operative complications.

 

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[25]

TÍTULO / TITLE:  - Sustained Autocrine Induction and Impaired Negative Feedback of Osteoclastogenesis in CD14(+) Cells of Giant Cell Tumor of Bone.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Pathol. 2013 Apr;182(4):1357-66. doi: 10.1016/j.ajpath.2012.12.021. Epub 2013 Feb 8.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ajpath.2012.12.021

AUTORES / AUTHORS:  - Avnet S; Salerno M; Zini N; Alberghini M; Gibellini D; Baldini N

INSTITUCIÓN / INSTITUTION:  - Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Italy. Electronic address: sofia.avnet@ior.it.

RESUMEN / SUMMARY:  - Giant cell tumor (GCT) of bone is a histologically benign osteolytic tumor featuring prominent osteoclast-like giant cells, mononuclear osteoclast precursors, and spindle-shaped stromal cells (SCs). Thus far, most studies have identified SCs as truly transformed elements that are responsible for sustained giant cell formation via receptor activator of NF-kappaB ligand (RANKL) paracrine induction. However, we have previously shown that SCs are hyperplastic, rather than neoplastic, and able to induce giant cell formation similar to that of normal mesenchymal SCs; we hypothesized that other cell subsets of GCTs might be  primarily relevant for the pathogenesis. In this study, we show that the nonproliferating CD14(+) cells of GCTs, exhibiting typical monoblast lineage features, secrete high amounts of RANKL, thereby activating a RANKL/RANK autocrine loop that determines sustained giant cell formation. Moreover, these cells also lack adequate negative feedback control of the RANKL signaling pathway, as determined by endogenous interferon beta. These data demonstrate that CD14(+) cells of GCTs are abnormally stimulated to limitless differentiation into multinucleated giant cells and provide useful suggestions for the development of  novel therapies.

 

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[26]

TÍTULO / TITLE:  - The interaction between smoking status and highly active antiretroviral therapy (HAART) use on the risk of Kaposi’s sarcoma (KS) in a cohort of HIV-infected men.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Cancer. 2013 Mar 19;108(5):1173-7. doi: 10.1038/bjc.2013.75. Epub 2013 Feb 19.

            ●● Enlace al texto completo (gratuito o de pago) 1038/bjc.2013.75

AUTORES / AUTHORS:  - Luu HN; Amirian ES; Scheurer ME

INSTITUCIÓN / INSTITUTION:  - 1] Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA [2] Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, the University of Texas Health Science Center-Houston, Houston, TX 77030, USA.

RESUMEN / SUMMARY:  - Background:Although the independent effects of smoking status and HAART are reported as lower risks against KS, their combined effects have not been explored. We examined whether there is an interaction between smoking status and  HAART use on the risk of KS development in an on-going US cohort of HIV-infected  men.Methods:Cox proportional hazards regression was used to analyse a total sample of 2736 participants of the Multicenter AIDS Cohort Study (MACS).Results:We identified 530 incident KS cases with a total follow-up time of 26 594 person-years (incidence rate: 2.00 out of 100 person-years). Current smoking status and HAART use were independently associated with a lower risk of KS development (hazard ratio - HR=0.56, 95% CI: 0.35-0.90, P=0.02 and HR=0.27, 95% CI: 0.16-0.48, P<0.0001, respectively). There was no evidence of multiplicative interaction between current smoking status and HAART use on KS risk (HR=2.14, 95% CI: 0.97-4.73, Pinteraction=0.06). Lower effect of smoking was only present among those not on HAART (HR=0.57, 95% CI: 0.35-0.92, P=0.02).Conclusion:The inverse association of cigarette smoking on KS risk may be limited to those not on HAART. The biological mechanism of smoking in KS carcinogenesis should be elucidated.

 

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[27]

TÍTULO / TITLE:  - Screening for Potential Targets for Therapy in Mesenchymal, Clear Cell, and Dedifferentiated Chondrosarcoma Reveals Bcl-2 Family Members and TGFbeta as Potential Targets.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Pathol. 2013 Apr;182(4):1347-56. doi: 10.1016/j.ajpath.2012.12.036. Epub 2013 Feb 15.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ajpath.2012.12.036

AUTORES / AUTHORS:  - van Oosterwijk JG; Meijer D; van Ruler MA; van den Akker BE; Oosting J; Krenacs T; Picci P; Flanagan AM; Liegl-Atzwanger B; Leithner A; Athanasou N; Daugaard S; Hogendoorn PC; Bovee JV

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

RESUMEN / SUMMARY:  - The mesenchymal, clear cell, and dedifferentiated chondrosarcoma subtypes are extremely rare, together constituting 10% to 15% of all chondrosarcomas. Their poor prognosis and lack of efficacious treatment emphasizes the need to elucidate the pathways playing a pivotal role in these tumors. We constructed tissue microarrays containing 42 dedifferentiated, 23 clear cell, and 23 mesenchymal chondrosarcomas and performed immunohistochemistry to study the expression of growth plate-signaling molecules and molecules shown to be involved in conventional chondrosarcoma. We observed high expression of SOX-9 and FGFR-3, as  well as aberrant cellular localization of heparan sulfate proteoglycans, in all subtypes. TGFbeta signaling through p-SMAD2 and PAI-1 was highly active in all chondrosarcoma subtypes, which suggests that TGFbeta inhibitors as a possible therapeutic strategy in rare chondrosarcoma subtypes. As in conventional chondrosarcoma, antiapoptotic proteins (Bcl-2, and/or Bcl-xl) were highly expressed in all subtypes. Inhibition with the BH-3 mimetic ABT-737 rendered dedifferentiated chondrosarcoma cell lines sensitive to doxorubicin or cisplatin. Our data indicate that antiapoptotic proteins may play an important role in chemoresistance, suggesting a promising role for targeting Bcl-2 family members in chondrosarcoma treatment, irrespective of the subtype.

 

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[28]

TÍTULO / TITLE:  - Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Cancer. 2013 Mar 5;108(4):836-47. doi: 10.1038/bjc.2012.579.

            ●● Enlace al texto completo (gratuito o de pago) 1038/bjc.2012.579

AUTORES / AUTHORS:  - Fujiwara-Okada Y; Matsumoto Y; Fukushi J; Setsu N; Matsuura S; Kamura S; Fujiwara T; Iida K; Hatano M; Nabeshima A; Yamada H; Ono M; Oda Y; Iwamoto Y

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan.

RESUMEN / SUMMARY:  - Background:Prognosis of osteosarcoma (OS) with distant metastasis and local recurrence is still poor. Y-box binding protein-1 (YB-1) is a multifunctional protein that can act as a regulator of transcription and translation and its high expression of YB-1 protein was observed in OS, however, the role of YB-1 in OS remains unclear.Methods:Y-box binding protein-1 expression in OS cells was inhibited by specific small interfering RNAs to YB-1 (si-YB-1). The effects of si-YB-1 in cell proliferation and cell cycle transition in OS cells were analysed in vitro and in vivo. The association of nuclear expression of YB-1 and clinical  prognosis was also investigated by immunohistochemistry.Results:Proliferation of  OS cell was suppressed by si-YB-1 in vivo and in vitro. The expression of cyclin  D1 and cyclin A were also decreased by si-YB-1. In addition, si-YB-1 induced G1/S arrest with decreased cyclin D1 and cyclin A in OS cell lines. Direct binding of  YB-1 in OS cell lines was also observed. Finally, the nuclear expression of YB-1  was significantly related to the poorer overall survival in OS patients.Conclusion:Y-box binding protein-1 would regulate cell cycle progression at G1/S and tumour growth in human OS cells in vitro and in vivo. Nuclear expression of YB-1 was closely associated with the prognosis of OS, thus, YB-1 simultaneously could be a potent molecular target and prognostic biomarker for OS.

 

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[29]

TÍTULO / TITLE:  - Somatic mutations of the mitochondrial genome in Chinese patients with Ewing sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Jan 31. pii: S0046-8177(12)00426-1. doi: 10.1016/j.humpath.2012.11.004.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.11.004

AUTORES / AUTHORS:  - Yu M; Wan Y; Zou Q

INSTITUCIÓN / INSTITUTION:  - Ontario Cancer Institute/Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, M5G 2M9 Ontario, Canada. Electronic address:  manyu@uhnres.utoronto.ca.

RESUMEN / SUMMARY:  - Somatic mutations in mitochondrial DNA (mtDNA) have been long proposed to drive initiation and progression of human malignancies. Our previous study revealed a high prevalence of somatic mutations in the D-loop region of mtDNA in Ewing sarcoma (EWS). However, it is unclear whether somatic mutations also occur in the coding regions of mtDNA in EWS. To test this possibility, in the present study, we sequenced the whole mitochondrial genome from 20 cases of EWS specimens and their corresponding peripheral blood samples. We identified a total of 6 somatic  mutations in the mtDNA coding regions in our EWS series, and 5 of them were missense or frame-shift mutations that have the potential to directly influence proper mitochondrial function. In combination with our earlier observations on the D-loop fragment, 70% (14/20) of EWS tissues appeared to harbor somatic mtDNA  mutations. Among the identified 25 somatic mutations, 19 (76%) were located in the D-loop control region, 1 (4%) was in the sequence of the tRNA(Val) gene, 1 (4%) was in the mitochondrial ATP synthase subunit 6 gene, and 4 (16%) occurred in genes encoding components of the mitochondrial respiratory complexes. In addition, patients carrying somatic mtDNA mutations did not show significant association with their clinicopathologic characteristics. Together, these findings suggest that somatic mtDNA mutations occur in both protein coding and noncoding regions of mtDNA, which may play critical roles in the pathogenesis of  EWS and should be further explored for its possible use as a novel marker for monitoring EWS occurrence and advancement.

 

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[30]

TÍTULO / TITLE:  - Regulation of viral and cellular gene expression by Kaposi’s sarcoma associated herpesvirus (KSHV) PAN RNA.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Mar 6.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.03111-12

AUTORES / AUTHORS:  - Rossetto CC; Tarrant-Elorza M; Verma S; Purushothaman P; Pari GS

INSTITUCIÓN / INSTITUTION:  - The University of Nevada, Reno, Department of Microbiology & Immunology, School of Medicine, Reno NV 89557.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma-associated herpesvirus (KSHV) is the cause of Kaposi’s sarcoma and body cavity lymphoma. In cell culture, KSHV results in a latent infection and lytic reactivation is usually induced with the expression of the K-Rta or by treatment with TPA and/or n-butyrate. Lytic infection is marked by the activation of the entire viral genomic transcription cascade and the production of infectious virus. KSHV infected cells express a highly abundant long noncoding transcript referred to as polyadenylated nuclear RNA (PAN RNA). PAN RNA interacts with specific demethylases and physically binds to the KSHV genome to mediate activation of viral gene expression. A recombinant BACmid lacking the PAN RNA locus fails to express K-Rta and does not produce virus. We now show that the lack of PAN RNA expression results in the failure of the initiation of the entire KSHV transcription program. In addition to previous findings of an interaction with demethylases, we show that PAN RNA binds to protein components of the polycomb repression complex 2 (PRC2). RNA Seq analysis using cell lines that express PAN RNA show that transcription involving the expression of proteins involved in cell cycle, immune response and inflammation is disregulated. Expression of PAN RNA in various cell types results in an enhanced growth phenotype, higher cell densities and increased survival compared to control cells. Also, PAN RNA expression mediates a decrease in the production of inflammatory cytokines. These data support a role for PAN RNA as a major global regulator of viral and cellular gene expression.

 

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[31]

TÍTULO / TITLE:  - Osteosarcoma of the pelvis: a monoinstitutional experience in patients younger than 41 years.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tumori. 2012 Nov;98(6):702-8. doi: 10.1700/1217.13492.

            ●● Enlace al texto completo (gratuito o de pago) 1700/1217.13492

AUTORES / AUTHORS:  - Ferrari S; Palmerini E; Fabbri N; Staals E; Ferrari C; Alberghini M; Picci P

INSTITUCIÓN / INSTITUTION:  - Sezione di Chemioterapia, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna, Italy. stefano.ferrari@ior.it

RESUMEN / SUMMARY:  - AIMS AND BACKGROUND: Information is scarce on systemic treatment of pelvic osteosarcoma because most chemotherapy protocols for osteosarcoma include patients with extremity tumors and aged up to 30-40 years. METHODS: Data on patients <41 years of age with high-grade pelvic osteosarcoma were prospectively  collected. Patients received two chemotherapy protocols consisting of methotrexate, cisplatin, doxorubicin (MAP) and standard-dose or high-dose ifosfamide. RESULTS: Forty patients between 11 and 36 years were included. The most frequent histological subtype was osteoblastic followed by chondroblastic (37.5%). Complete surgical remission was achieved in 65% of patients. Eighteen patients had MAP/standard-dose ifosfamide, 22 MAP/high-dose ifosfamide. Primary chemotherapy was given to 25 patients and 6 (24%) of them had a good histological response. Median follow-up was 32 months (range, 4-134). Five-year overall survival was 27.5%: 33% in localized and 0 in metastatic patients ( P = 0.02); 45% in patients with complete surgical remission and 0 for patients without complete surgical remission (P = 0.001). Local recurrence rate was 46%. In patients with complete surgical remission, 5-year overall survival was 32% with MAP/standard-dose ifosfamide and 59% with MAP/high-dose ifosfamide regimen (P = 0.3). CONCLUSIONS: Local control is the major issue in the treatment of pelvic osteosarcoma. Poor pathological response and high incidence of chondroblastic variant indicate different characteristics between pelvic and extremity osteosarcoma. Chemotherapy with MAP and high-dose ifosfamide might be beneficial  in patients with pelvic osteosarcoma and warrants further investigation.

 

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[32]

- CASTELLANO -

TÍTULO / TITLE:Autologe Stammzellentransplantation bei erwachsenen Patienten mit Sarkomen der Ewing Familie - eine Einzelzentrum-Analyse.

TÍTULO / TITLE:  - Autologous stem cell transplantation in adults with metastatic sarcoma of the Ewing family: a single centre experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Wien Klin Wochenschr. 2013 Mar;125(5-6):129-133. Epub 2013 Feb 26.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00508-013-0328-0

AUTORES / AUTHORS:  - Lamm W; Rabitsch W; Kostler WJ; Kalhs P; Ubl P; Brodowicz T

INSTITUCIÓN / INSTITUTION:  - Sarcoma Program, Clinical Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

RESUMEN / SUMMARY:  - BACKGROUND: Adults with metastatic Ewing family sarcomas (ES) after being treated with standard therapy for localised disease have limited treatment options with curative intent. The aim of this retrospective single centre study was to evaluate the efficacy of autologous stem cell transplantation (ASCT) in this patient population. METHODS: We report on seven consecutive patients with ES. Four patients with initial localised disease developed distant metastases after being treated with initial standard pre-operative chemotherapy followed by surgery and subsequent standard post-operative chemotherapy. Three patients with  initial metastatic disease were pre-treated with standard polychemotherapy. All patients received high-dose chemotherapy (HDCT) followed by ASCT for metastatic disease. RESULTS: For patients with initial metastatic disease, partial remission (PR) was achieved in three patients prior to HDCT. Type of response subsequent to ASCT was complete response (CR) in four patientswith initial localised disease and CR in two patients with initial metastatic disease. No patient died within the first 100 days after HDCT. Side effects were rare and manageable. CONCLUSION: This retrospective analysis suggests that ASCT may be considered in patients with metastatic ES, previously treated with standard therapy.

 

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[33]

TÍTULO / TITLE:  - Kaposi Sarcoma-Associated Herpesvirus Induces Rapid Release of Angiopoietin-2 from Endothelial Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Mar 27.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.03303-12

AUTORES / AUTHORS:  - Ye FC; Zhou FC; Nithianantham S; Chandran B; Yu X; Weinberg A; Gao SJ

INSTITUCIÓN / INSTITUTION:  - Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106.

RESUMEN / SUMMARY:  - Kaposi sarcoma-associated herpesvirus (KSHV) stimulates proliferation, angiogenesis, and inflammation to promote Kaposi sarcoma (KS) tumor growth, which involves various growth factors and cytokines. Previously, we found that KSHV infection of human umbilical vein endothelial cells (HUVECs) induces a transcriptional induction of the pro-angiogenic and pro-inflammatory cytokine angiopoietin-2 (Ang-2). Here we report that KSHV induces rapid release of Ang-2 that is pre-synthesized and stored in the Weibel-Palade bodies (WPB) of endothelial cells upon binding to its integrins receptors. Blocking viral binding to integrins inhibits Ang-2 release. KSHV binding activates the integrin tyrosine kinase receptors signaling pathways, leading to tyrosine phosphorylation of focal adhesion kinase (FAK), the tyrosine kinase Src, and the Calalpha2 subunit of L-type calcium channel to trigger rapid calcium (Ca2+) influx. Pre-treatment of endothelial cells with specific inhibitors of protein tyrosine kinases inhibits KSHV induced Ca2+ influx and Ang-2 release. Inhibition of Ca2+ mobilization with  calcium channel blockers also inhibits Ang-2 release. Thus, the interaction between KSHV and its integrins receptors plays a key role in regulating rapid Ang-2 release from endothelial cells. This finding highlights a novel mechanism of viral induction of angiogenesis and inflammation, which might play important roles in the early event of KS tumor development.

 

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[34]

TÍTULO / TITLE:  - Downregulation of phosphatidylethanolamine binding protein 1 associates with clinical risk factors in gastrointestinal stromal tumors, but not with activation of the RAF-1-MEK-ETV1 pathway.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Lett. 2013 Jan 31. pii: S0304-3835(13)00090-6. doi: 10.1016/j.canlet.2013.01.044.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.canlet.2013.01.044

AUTORES / AUTHORS:  - Schoppmann SF; Beer A; Nirtl N; Ba-Ssalamah A; Brodowicz T; Streubel B; Birner P

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Medical University of Vienna, Austria.

RESUMEN / SUMMARY:  - Aim of this study was to investigate phosphatidylethanolamine binding protein 1 (PEBP1) in GIST and its relations with MEK1/2 activation and ETV1 by immunohistochemistry. Loss of PEBP1 was found in 22/161 (13.7%) GIST, was associated with clinical risk factors and with a trend towards shorter disease free survival, but not with pMEK1/2 and ETV1 expression. So downregulation of PEBP1 does not activate the Ras-Raf-1-MEK1/2-ERK1/2 pathway by phosphorylation of MEK1/2 and does not influence ETV1 expression in GIST. Loss of PEBP1 associates with clinical risk factors, but since no significant influence on survival was found, further studies are required.

 

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[35]

TÍTULO / TITLE:  - Systemic mastocytosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Blood. 2013 Feb 14;121(7):1071.

AUTORES / AUTHORS:  - Bouvier S; Arnaud A

INSTITUCIÓN / INSTITUTION:  - Centre Hospitalier Universitaire de Nimes.

 

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[36]

TÍTULO / TITLE:  - Ovarian tissue cryopreserved for fertility preservation from patients with Ewing  or other sarcomas appear to have no tumour cell contamination.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cancer. 2013 Feb 26. pii: S0959-8049(13)00106-8. doi: 10.1016/j.ejca.2013.01.032.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejca.2013.01.032

AUTORES / AUTHORS:  - Greve T; Wielenga VT; Grauslund M; Sorensen N; Christiansen DB; Rosendahl M; Yding Andersen C

INSTITUCIÓN / INSTITUTION:  - Laboratory of Reproductive Biology, Rigshospitalet - Copenhagen University Hospital, Denmark. Electronic address: tinegreve@gmail.com.

RESUMEN / SUMMARY:  - AIM: The chemotherapy required to treat patients with sarcoma may as a side-effect induce infertility in girls and young women. If these patients have ovarian cortical tissue cryopreserved prior to chemotherapy, they may, if necessary, have the tissue transplanted and restore their fertility. The aim of this study was to evaluate the risk of residual cancer cells in the ovarian cortex intended for transplantation. PATIENTS AND METHODS: Ovarian tissue stored  for fertility preservation from 16 surviving patients diagnosed with sarcoma (nine with Ewing sarcomas, four with osteosarcomas, two with synovial sarcomas and one with chondrosarcoma) was evaluated for the presence of malignant cells by histology and by transplantation to immunodeficient mice for 20weeks. A fraction  of the tissue from patients with Ewing sarcoma was also evaluated for the presence of the molecular marker EWS-FLI1 by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The transplant itself and selected murine organs were analysed for the presence of malignant cells by histology. RESULTS: All the mice accommodated the human tissue for 20weeks of transplantation period  with none of the mice developing any sign of cancer. In no instance were any cancer cells detected by histology or RT-qPCR. CONCLUSION: Ovarian tissue from patients with sarcoma appears to be without metastatic malignant cells in numbers that allow detection. Although the actual pieces of ovarian tissue used for transplantation remain unchecked, the current data indicate that the procedure is safe at least in patients that survive the sarcoma disease.

 

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[37]

TÍTULO / TITLE:  - Malignant inflammatory myofibroblastic tumor of the prostate.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Apr 1;31(10):e144-7. doi: 10.1200/JCO.2012.44.4851. Epub 2013  Feb 11.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.44.4851

AUTORES / AUTHORS:  - Liu C; Zhao X; Zhao Z; Lu P; Jin F; Li G

INSTITUCIÓN / INSTITUTION:  - Department of Breast Surgery, General Surgery, First Hospital of China Medical University, Shenyang, China 110001; zhongguoyida2011@163.com.

 

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[38]

TÍTULO / TITLE:  - Mullerian Carcinosarcoma Arising From Intestinal Endometriosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.44.1600

AUTORES / AUTHORS:  - Agito MD; Rehmus EH; Powell AT

INSTITUCIÓN / INSTITUTION:  - Akron General Medical Center, Akron, OH.

 

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[39]

TÍTULO / TITLE:  - Anorectal gastrointestinal stromal tumors: a retrospective multicenter analysis of 15 cases emphasizing their high local recurrence rate and the need for standardized therapeutic approach.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Colorectal Dis. 2013 Feb 13.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00384-013-1655-3

AUTORES / AUTHORS:  - Agaimy A; Vassos N; Markl B; Meidenbauer N; Kohler J; Spatz J; Hohenberger W; Haller F; Croner RS; Schneider-Stock R; Matzel K

INSTITUCIÓN / INSTITUTION:  - Institute of Pathology, University Hospital Erlangen, Krankenhausstrasse 8-10, 91054, Erlangen, Germany, abbas.agaimy@uk-erlangen.de.

RESUMEN / SUMMARY:  - PURPOSE: This study aims to report our multicenter experience with diagnosis, management, and prognosis of anorectal gastrointestinal stromal tumors (GIST). PATIENTS AND METHODS: We retrospectively reviewed cases treated and/or followed up at our institutions in the period 2000-2011. RESULTS: Fifteen patients were identified (eight men and seven women; mean age, 55 years). Presenting symptoms were rectal/perirectal (eight), rectovaginal space (four), or retrovesical/prostatic (three) mass. Primary surgical treatment was local excision (six), deep anterior resection (eight), and palliative diagnostic excision (one). Tumor mean size was 4.8 cm. All but two cases were high risk (Miettinen and Lasota, Semin Diagn Pathol 23:70-83, 2006). R0 resection was achieved in 46 % of cases: one of six local excisions vs. five of seven deep anterior resection (16 vs. 71 %, respectively). All three cases who received total mesorectal excision had R0. Non-R0 status was mainly due to opening of tumor capsule at surgery (Rx). Seven of 14 patients (50 %) developed >/=1 pelvic  local recurrences at a mean period of 48.4 months (mean follow-up, 61.6 months).  Only two patients developed distant metastasis (adrenal, liver, and peritoneal).  Recurrences developed after Rx (three), R1 (two), and unknown R-status (two). Successful mutational analysis in 13 patients revealed KIT mutations in all (10 exon 11, 2 exon 9, and 1 exon 13). CONCLUSION: Our results confirm the high local recurrence rate of anorectal GISTs (50 %) which correlates with the common practice of suboptimal oncological primary tumor resection (Rx or R1 = 7/13). This uncommon subset of GISTs needs more standardized oncological surgical approach to minimize the propensity for local disease recurrence.

 

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[40]

TÍTULO / TITLE:  - Osteoid Osteoma: MR-guided Focused Ultrasound for Entirely Noninvasive Treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Radiology. 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1148/radiol.13120873

AUTORES / AUTHORS:  - Napoli A; Mastantuono M; Marincola BC; Anzidei M; Zaccagna F; Moreschini O; Passariello R; Catalano C

INSTITUCIÓN / INSTITUTION:  - Department of Radiological, Oncological and Anatomo-pathological Sciences and Department of Orthopedics and Traumatology, Policlinico Umberto I-Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.

RESUMEN / SUMMARY:  - Purpose:To determine the preliminary feasibility, safety, and clinical efficacy of magnetic resonance (MR)-guided focused ultrasound for the treatment of painful osteoid osteoma.Materials and Methods:This prospective institutional review board-approved study involved six consecutive patients (five males and one female; mean age, 21 years) with a diagnosis of osteoid osteoma based on clinical and imaging findings. All patients underwent MR-guided focused ultrasound ablation after providing informed consent. Lesions located in the vertebral body  were excluded. The number of sonications and the energy deposition were recorded. Treatment success was determined at 1, 3, and 6 months after treatment. A visual  analog scale (VAS) score for pain was used to assess changes in symptoms. MR imaging features of osteoid osteoma (edema, hyperemia, and nidus vascularization) were considered at baseline and at imaging follow-up.Results:Treatment was performed with a mean of 4 sonications +/-1.8 (standard deviation), with a mean energy deposition of 866 J +/- 211. No treatment- or anesthesia-related complications occurred. The pre- and posttreatment mean VAS scores significantly  differed (7.9 +/-1.4 and 0.0 +/- 0.0, respectively). At imaging, the edema and hyperemia associated with osteoid osteoma gradually disappeared in all lesions. However, nidus vascularization still persisted after treatment in four of six patients.Conclusion:This limited series demonstrated that MR-guided focused ultrasound treatment of osteoid osteoma can be performed safely with a high rate  of success and without apparent treatment-related morbidity.© RSNA, 2013.

 

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[41]

TÍTULO / TITLE:  - Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Res. 2013 Feb 15;73(4):1298-307. doi: 10.1158/0008-5472.CAN-12-2086. Epub  2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1158/0008-5472.CAN-12-2086

AUTORES / AUTHORS:  - Zhang K; Chu K; Wu X; Gao H; Wang J; Yuan YC; Loera S; Ho K; Wang Y; Chow W; Un F; Chu P; Yen Y

INSTITUCIÓN / INSTITUTION:  - Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA 91010, USA.

RESUMEN / SUMMARY:  - Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first comparatively examined the amplification and expression of FRS2  with CDK4 and MDM2 in dedifferentiated liposarcoma (DDLS) and undifferentiated high-grade pleomorphic sarcoma (UHGPS). Amplification and expression of the three genes were identified in 90% to 100% (9-11 of 11) of DDLS, whereas that of FRS2,  CDK4, and MDM2 were observed in 55% (41 of 75), 48% (36 of 75), and 44% (33/75) of clinically diagnosed UHGPS, suggesting that these “UHGPS” may represent DDLS despite lacking histologic evidence of lipoblasts. Immunohistochemical analysis of phosphorylated FRS2 protein indicated that the FGFR/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas. Moreover, we found that FRS2 and FGFRs proteins are highly expressed and functional in three high-grade liposarcoma cell lines: FU-DDLS-1, LiSa-2, and SW872. Importantly, the FGFR selective inhibitor NVP-BGJ-398 significantly inhibited the growth of FU-DDLS-1 and LiSa-2 cells with a concomitant suppression of FGFR signal transduction. Attenuation of FRS2 protein in FU-DDLS-1 and LiSa-2  cell lines decreased the phosphorylated extracellular signal-regulated kinase ½ and AKT and repressed cell proliferation. These findings indicate that analysis of FRS2 in combination with CDK4 and MDM2 will more accurately characterize pathologic features of high-grade liposarcomas. Activated FGFR/FRS2 signaling may play a functional role in the development of high-grade liposarcomas, therefore,  serve as a potential therapeutic target.

 

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[42]

TÍTULO / TITLE:  - Virilizing sclerosing-stromal tumor of the ovary in a young woman with McCune Albright syndrome: clinical, pathological, and immunohistochemical studies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Endocrinol Metab. 2013 Feb;98(2):E314-20. doi: 10.1210/jc.2012-3551. Epub  2013 Jan 30.

            ●● Enlace al texto completo (gratuito o de pago) 1210/jc.2012-3551

AUTORES / AUTHORS:  - Boussaid K; Meduri G; Maiza JC; Gennero I; Escourrou G; Bros A; Leguevaque P; Bennet A; Caron P

INSTITUCIÓN / INSTITUTION:  - Department of Endocrinology and Metabolic Diseases, Centre Hospitalier Universitaire Rangueil-Larrey, 24 Chemin de Pourvouville, TSA 30030, 31059 Toulouse Cedex 9, France.

RESUMEN / SUMMARY:  - CONTEXT: McCune-Albright syndrome (MAS) is characterized by polyostotic fibrous dysplasia, cafe-au-lait skin pigmentations, and gonadotropin-independent sexual precocious puberty, resulting from a somatic postzygotic activating mutation of the GNAS1 gene. SETTING: We report a virilizing sclerosing-stromal tumor of the ovary in a young female with MAS. PATIENT: She presented polyostotic fibrous dysplasia of the left upper and lower limbs and a cafe-au-lait skin spot in the posterior area of the neck. She had a history of precocious puberty, diagnosed at the age of 6 years and treated with cyproterone acetate until the age of 10 years; then she developed central puberty with severe oligomenorrhea. At the age  of 23 years, she was hospitalized for a virilization syndrome including hirsutism, acne, deepening of the voice, amenorrhea, and clitoromegaly. Serum levels of T were dramatically increased (1293 ng/dl; normal range, 10-80). The abdominal computed tomography scan revealed a solid mass located on the left ovary. INTERVENTION: An ovariectomy was performed, and histological examination revealed a sclerosing-stromal tumor with pseudolobular pattern. RESULTS: Immunohistochemical studies revealed that the tumor cells expressed all steroidogenic enzymes involved in androgen synthesis. Molecular analysis revealed that ovarian tumor cells harbored the Arg 201 activating mutation in the GNAS1 gene. After surgery, T levels returned to normal, the patient retrieved a normal  gonadal function, and she was able to become pregnant. CONCLUSION: This observation extends the clinical spectrum of ovarian pathology of women with MAS. However, the mechanisms causing this ovarian tumor remain unclear, even if the gsp oncogene has been implicated in the pathogenesis of some gonadal tumors.

 

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[43]

TÍTULO / TITLE:  - Gene Expression Patterns of Insulin-Like Growth Factor 2 in Human Uterine Fibroid Tissues: A Genetic Study with Clinical Correlations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gynecol Obstet Invest. 2013 Mar 6.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000347017

AUTORES / AUTHORS:  - Csatlos E; Rigo Jr J; Laky M; Joo JG

INSTITUCIÓN / INSTITUTION:  - First Department of Gynecology and Obstetrics, Semmelweis University, Budapest, Hungary.

RESUMEN / SUMMARY:  - Background/Aims: We investigated insulin-like growth factor 2 (IGF-2) gene activity in human uterine fibroid tissue. Results of the genetic testing were correlated with clinical data. Methods: We obtained samples from patients treated for uterine fibroid and from patients undergoing hysterectomy due to other indications (control group). The examined group (with fibroid) contained 101 cases, while the control group was similar with 110 patients. Gene expression values were determined using the standard PCR technique. Clinical data were available from the computer database of the department. Results: IGF-2 gene expression was significantly higher in the fibroid group. There was no correlation between increase in gene activity and the number of tumors. History of previous uterine fibroid did not seem to predict IGF-2 gene activity in the current fibroid tumor tissue. IGF-2 gene expression did not correlate with cumulative duration of lactation following prior pregnancies. Conclusion: IGF-2 gene activity is significantly increased in leiomyoma tissue compared to normal myometrium. Familial aggregation of uterine fibroids is not significantly associated with increased IGF-2 gene activity; other genes may have a stronger etiological role. It appears that the genetic factors potentially important in the development of familiar uterine leiomyoma are not related to the IGF-2 gene.

 

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[44]

TÍTULO / TITLE:  - Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Res. 2013 Mar 27.

            ●● Enlace al texto completo (gratuito o de pago) 1158/0008-5472.CAN-12-3947

AUTORES / AUTHORS:  - Li Z; Zhang Y; Ramanujan K; Ma Y; Kirsch DG; Glass DJ

INSTITUCIÓN / INSTITUTION:  - Muscle Diseases, Novartis Institutes of Biomedical Research.

RESUMEN / SUMMARY:  - Embryonic rhabdomyosarcoma (ERMS) is the most common soft-tissue tumor in children. Here we report the identification of the minor groove DNA binding factor HMGA2 as a driver of ERMS development. HMGA2 was highly expressed in normal myoblasts and ERMS cells, where its expression was essential to maintain cell proliferation, survival in vitro and tumor outgrowth in vivo. Mechanistic investigations revealed that upregulation of the IGF mRNA binding protein IGF2BP2 was critical for HMGA2 action. In particular, IGF2BP2 was essential for mRNA and  protein stability of NRAS, a frequently mutated gene in ERMS. shRNA-mediated attenuation of NRAS or pharmacological inhibition of the MEK/ERK effector pathway demonstrated that NRAS and NRAS-mediated signaling was required for tumor maintenance. Taken together, these findings implicate the HMGA2-IGFBP2-NRAS signaling pathway as a critical oncogenic driver in ERMS.

 

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[45]

TÍTULO / TITLE:  - mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Res. 2013 Apr 1;73(7):2235-46. doi: 10.1158/0008-5472.CAN-12-1851. Epub 2013 Feb 4.

            ●● Enlace al texto completo (gratuito o de pago) 1158/0008-5472.CAN-12-1851

AUTORES / AUTHORS:  - Roy D; Sin SH; Lucas A; Venkataramanan R; Wang L; Eason A; Chavakula V; Hilton IB; Tamburro KM; Damania B; Dittmer DP

INSTITUCIÓN / INSTITUTION:  - Authors’ Affiliations: Curriculum in Genetics and Molecular Biology; Department of Microbiology and Immunology; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.

RESUMEN / SUMMARY:  - Kaposi sarcoma originates from endothelial cells and it is one of the most overt  angiogenic tumors. In Sub-Saharan Africa, where HIV and the Kaposi sarcoma-associated herpesvirus (KSHV) are endemic, Kaposi sarcoma is the most common cancer overall, but model systems for disease study are insufficient. Here, we report the development of a novel mouse model of Kaposi sarcoma, where KSHV is retained stably and tumors are elicited rapidly. Tumor growth was sensitive to specific allosteric inhibitors (rapamycin, CCI-779, and RAD001) of the pivotal cell growth regulator mTOR. Inhibition of tumor growth was durable up to 130 days and reversible. mTOR blockade reduced VEGF secretion and formation of tumor vasculature. Together, the results show that mTOR inhibitors exert a direct anti-Kaposi sarcoma effect by inhibiting angiogenesis and paracrine effectors, suggesting their application as a new treatment modality for Kaposi sarcoma and other cancers of endothelial origin. Cancer Res; 73(7); 2235-46. ©2012 AACR.

 

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[46]

TÍTULO / TITLE:  - Kaposi’s sarcoma: a reversible cause of ARDS in HIV-infected patient.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Intensive Care Med. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00134-013-2891-2

AUTORES / AUTHORS:  - Repesse X; Au SM; Charron C; Vieillard-Baron A

INSTITUCIÓN / INSTITUTION:  - Assistance Publique-Hopitaux de Paris, Boulogne-Billancourt, 92100, France, xavier.repesse@apr.aphp.fr.

 

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[47]

TÍTULO / TITLE:  - Immune reconstitution inflammatory syndrome associated with kaposi sarcoma: higher incidence and mortality in Africa than in the UK.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - AIDS. 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 1097/QAD.0b013e328360a5a1

AUTORES / AUTHORS:  - Letang E; Lewis JJ; Bower M; Mosam A; Borok M; Campbell TB; Naniche D; Newsom-Davis T; Shaik F; Fiorillo S; Miro JM; Schellenberg D; Easterbrook PJ

INSTITUCIÓN / INSTITUTION:  - aBarcelona Centre for International Health Research (CRESIB, Hospital Clinic-Universitat de Barcelona), Barcelona, España bCentro de Investigacao em Saude de Manhica (CISM), Manhica, Maputo province, Mozambique cDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine (LSH&TM), London, UK dDepartment of Oncology, Chelsea and Westminster Hospital, London, UK. eDepartment of Infectious Diseases, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa fDepartment of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe gDivision of Infectious Diseases, Department of Medicine, University of Colorado  Denver, Aurora, USA hInfectious Diseases Service, Hospital Clinic / IDIBAPS, Universitat de Barcelona, Barcelona, España iDepartment of Disease Control, London School of Hygiene and Tropical Medicine (LSH&TM), London, UK. jHIV Department, World Health Organisation, Geneva, Switzerland.

RESUMEN / SUMMARY:  - OBJECTIVES:: Assess the incidence, predictors, and outcomes of Kaposi sarcoma-associated paradoxical immune reconstitution inflammatory syndrome (KS-IRIS) in antiretroviral (ART)-naive HIV-infected patients with KS initiating  ART in both well-resourced and limited-resourced settings. DESIGN:: Pooled analysis of three prospective cohorts of ART-naive HIV-infected patients with KS  from Sub-Saharan Africa (SSA) and one from the UK. METHODS:: KS-IRIS case definition was standardised across sites. Cox regression and Kaplan-Meier survival analysis were used to identify the incidence and predictors of KS-IRIS and KS-associated mortality. RESULTS:: Fifty-eight of 417 (13.9%) eligible subjects experienced KS-IRIS with an incidence 2.5 times higher in the African vs. European cohorts (p = 0.001). ART alone as initial KS treatment (HR 2.97); T1 KS-stage (HR 2.96); and plasma HIV-1 RNA >5 log10 copies/ml (HR 2.14) independently predicted KS-IRIS at baseline. Detectable plasma KS-associated Herpes Virus (KSHV) DNA additionally predicted KS-IRIS among the 254 patients with KSHV DNA assessed (HR 2.98). Nineteen KS-IRIS patients died, all in SSA. KS-mortality was 3.3-fold higher in Africa, and was predicted by KS-IRIS (HR 19.24), lack of chemotherapy (HR 2.35), pre-ART CD4 < 200 cells/mul (HR 2.04) and detectable baseline KSHV DNA (HR 2.12). CONCLUSIONS:: KS-IRIS incidence and mortality are higher in SSA than in the UK. This is largely explained by the more advanced KS disease and lower chemotherapy availability. KS-IRIS is a major contributor to KS-associated mortality in Africa. Our results support the need to increase awareness on KS-IRIS, encourage earlier presentation, referral and diagnosis of KS, and advocate on access to systemic chemotherapy in Africa.

 

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[48]

TÍTULO / TITLE:  - Somatic mitochondrial DNA mutations in Chinese patients with osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Exp Pathol. 2013 Feb 27. doi: 10.1111/iep.12015.

            ●● Enlace al texto completo (gratuito o de pago) 1111/iep.12015

AUTORES / AUTHORS:  - Yu M; Wan Y; Zou Q

INSTITUCIÓN / INSTITUTION:  - Ontario Cancer Institute/Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, ON, Canada.

RESUMEN / SUMMARY:  - Somatic mutations in mitochondrial DNA (mtDNA) have been long proposed to drive the pathogenesis and progression of human malignancies. Previous investigations have revealed a high frequency of somatic mutations in the D-loop control region  of mtDNA in osteosarcoma. However, little is known with regard to whether or not  somatic mutations also occur in the coding regions of mtDNA in osteosarcoma. To test this possibility, in the present study we screened somatic mutations over the full-length mitochondrial genome of 31 osteosarcoma tumour tissue samples, and corresponding peripheral blood samples from the same cohort of patients. We detected a sum of 11 somatic mutations in the mtDNA coding regions in our series. Nine of them were missense or frameshift mutations that have the potential to hamper mitochondrial respiratory function. In combination with our earlier observations on the D-loop fragment, 71.0% (22/31) of patients with osteosarcoma  carried at least one somatic mtDNA mutation, and a total of 40 somatic mutations  were identified. Amongst them, 29 (72.5%) were located in the D-loop region, two  (5%) were in the sequences of the tRNA genes, two (5%) were in the mitochondrial  ATP synthase subunit 6 gene and seven (17.5%) occurred in genes encoding components of the mitochondrial respiratory complexes. In addition, somatic mtDNA mutation was not closely associated with the clinicopathological characteristics  of osteosarcoma. Together, these findings suggest that somatic mutations are highly prevalent events in both coding and non-coding regions of mtDNA in osteosarcoma. Some missense and frameshift mutations are putatively harmful to proper mitochondrial activity and might play vital roles in osteosarcoma carcinogenesis.

 

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[49]

TÍTULO / TITLE:  - Pediatric case report on magnetic resonance imaging/transrectal ultrasound-fusion biopsy of rhabdomyosarcoma of the bladder/prostate: a new tool to reduce therapy-associated morbidity?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Urology. 2013 Feb;81(2):417-20. doi: 10.1016/j.urology.2012.10.043.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.urology.2012.10.043

AUTORES / AUTHORS:  - Kuru TH; Roethke MC; Nyarangi-Dix J; Okouoyo S; Stockklausner C; Schenk JP; Debus J; Roth W; Teber D; Pahernik S; Schlemmer HP; Hohenfellner M; Hadaschik BA

INSTITUCIÓN / INSTITUTION:  - Department of Urology, UniversityHospital Heidelberg, Heidelberg, Germany.

RESUMEN / SUMMARY:  - Rhabdomyosarcomas are the most common soft tissue sarcomas in children. Here we present management of an 18-month-old boy with metastatic rhabdomyosarcoma of the bladder/prostate. After radiochemotherapy, high-spatial-resolution 3-Tesla multiparametric magnetic resonance imaging (MRI) showed regressive systemic disease but a residual mass at the right seminal vesicle. For histologic re-evaluation, 3-dimensional-controlled stereotactic MRI/transrectal ultrasound (TRUS)-fusion biopsy specimens were taken. Because histologic analysis showed nonvital tissue, a decision could be made against adjuvant radical cystoprostatectomy. Advanced 3-Tesla imaging and MRI/TRUS-fusion biopsies in children are feasible and represent an effective tool to examine suspicious pelvic lesions. Depending on histology, this can lead to a significant reduction  of therapy-associated morbidity.

 

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[50]

TÍTULO / TITLE:  - Incidence and relative survival of chordomas: The standardized mortality ratio and the impact of chordomas on a population.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer. 2013 Mar 15. doi: 10.1002/cncr.28032.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cncr.28032

AUTORES / AUTHORS:  - Smoll NR; Gautschi OP; Radovanovic I; Schaller K; Weber DC

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Geneva University Medical Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland. nrsmoll@me.com.

RESUMEN / SUMMARY:  - BACKGROUND: Chordomas are rare bone tumors arising from remnants of the embryonic notochord. METHODS: Data for this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (1973-2009) to calculate the incidence, relative survival (RS), and standardized  mortality ratio (SMR) of patients diagnosed with intracranial and extracranial chordomas and to assess the effects of age and sex on this disease. RESULTS: The  overall incidence of extracranial and intracranial chordomas was 8.4 per 10 million population. The median overall survival of patients with chordoma patients was 7.7 years. The median survival was 7.7 years for male patients and 7.8 years for female patients. Younger patients (aged <40 years) survived longer  compared with older patients (10-year RS, 68% vs 43%). The estimated age-standardized 5-year, 10-year, and 20-year RS rates was 72%, 48%, and 31%, respectively. The SMR in the overall cohort was 4.6 (95% confidence interval, 4.22-5.0) or 21.0 (95% confidence interval, 16.6-27.2) in young adult patients and 3.0 (95% confidence interval, 2.6-3.4) in elderly patients. CONCLUSIONS: The  elderly had a more aggressive form of this disease; and, other than the incidence, sex did not influence outcome in this disease. The study of chordomas  presents a good case for the contribution that the SMR can have on measuring the  impact of a disease on a population of patients. Although the younger population  has better survival rates, the impact (SMR) in the younger age groups is much higher than in older populations. Cancer 2013. Esta es una cita bibliográfica que va por delante de la publicación en papel. La fecha indicada en la cita provista, NO corresponde con la fecha o la cita bibliográfica de la publicación en papel. La cita bibliográfica definitiva (con el volumen y su paginación) saldrá en 1 ó 2 meses a partir de la fecha de la emisión electrónica-online. *** This is a bibliographic record ahead of the paper publication. The given date in the bibliographic record does not correspond to the date or the bibliographic citation on the paper publication. The publisher will provide the final bibliographic citation (with the volume, and pagination) within 1 or 2 months from the date the record was published online. © 2013 American Cancer Society.

 

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[51]

TÍTULO / TITLE:  - Inhibition of the canonical Wnt pathway by high glucose can be reversed by parathyroid hormone-related protein in osteoblastic cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cell Biochem. 2013 Mar 13. doi: 10.1002/jcb.24535.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jcb.24535

AUTORES / AUTHORS:  - Lopez-Herradon A; Portal-Nunez S; Garcia-Martin A; Lozano D; Perez-Martinez FC; Cena V; Esbrit P

INSTITUCIÓN / INSTITUTION:  - Laboratorio de Metabolismo Mineral y Oseo, Instituto de Investigacion Sanitaria (IIS)-Fundacion Jimenez Diaz and Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad (RETICEF), Madrid, España.

RESUMEN / SUMMARY:  - Recent in vivo findings suggest that the bone sparing capacity of parathyroid hormone-related protein (PTHrP) in diabetic mice might be due at least in part through targeting a suppressed Wnt/beta-catenin pathway in osteoblasts. We here aimed to examine the inhibitory action of a high glucose environment on specific  components of the canonical Wnt pathway, and the putative compensatory effects of PTHrP, in osteoblastic cell cultures. Mouse osteoblastic MC3T3-E1 cells and primary cultures of fetal mouse calvaria were exposed to normal (5.5 mM) or high  (25 mM) D-glucose (HG), with or without PTHrP (1-36) or PTHrP (107-139) for different times. In some experiments, MC3T3-E1 cells were incubated with the Wnt  pathway activators Wnt3a and LiCl, or were transfected with plasmids encoding either a mutated beta-catenin that cannot be targeted for degradation or a human  PTHrP (-36/+139) cDNA, or the corresponding empty plasmid, in the presence or absence of HG. The gene expression of Wnt3a and low density receptor-like proteins (LRP)-5 and 6, as well as beta-catenin protein stabilization and beta-catenin-dependent transcription activity were evaluated. Oxidative stress status under HG condition was also assessed. The present data demonstrate that HG can target different components of the canonical Wnt pathway, while beta-catenin  degradation appears to be a key event leading to inhibition of Wnt/beta-catenin signalling in mouse osteoblastic cells. Both PTHrP peptides tested were able to counteract this deleterious action of HG. These in vitro findings also provide new clues to understand the underlying mechanisms whereby PTHrP can increase bone formation. J. Cell. Biochem. © 2013 Wiley Periodicals, Inc.

 

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[52]

TÍTULO / TITLE:  - Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Carcinogenesis. 2013 Mar 11.

            ●● Enlace al texto completo (gratuito o de pago) 1093/carcin/bgt065

AUTORES / AUTHORS:  - Li Y; Zhang J; Zhang L; Si M; Yin H; Li J

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics and.

RESUMEN / SUMMARY:  - Notch signaling pathway plays critical roles in human cancers, including osteosarcoma, suggesting that the discovery of specific agents targeting Notch would be extremely valuable for osteosarcoma. Our previous studies have shown that diallyl trisulfide (DATS) inhibits proliferation of osteosarcoma cells by triggering cell cycle arrest and apoptosis in vitro. However, the underlying mechanism is still unclear. In this study, we found that DATS suppressed cell survival, wound-healing capacity, invasion and angiogenesis in osteosarcoma cells. These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1, resulting in the inhibition of osteosarcoma cell proliferation, invasion and angiogenesis. These results clearly suggest that DATS inhibited osteosarcoma  growth and aggressiveness via a novel mechanism targeting a Notch-miRNA regulatory circuit. Our data provide the first evidence that the downregulation of Notch-1 and reexpression of miRNAs by DATS may be an effective approach for the treatment of osteosarcoma.

 

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[53]

TÍTULO / TITLE:  - Metastasizing “benign” cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2013 Apr;37(4):484-95. doi: 10.1097/PAS.0b013e31827070d4.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e31827070d4

AUTORES / AUTHORS:  - Doyle LA; Fletcher CD

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.

RESUMEN / SUMMARY:  - Cutaneous fibrous histiocytoma (FH) is considered a benign tumor; however, certain types of FH have been shown to have a tendency for local recurrence, and  there are rare reported cases of metastasis. In this study, 16 cases of morphologically benign FH with locoregional or distant metastasis were identified in consult files. Pathologic features of primary, recurrent, and metastatic tumors, as well as clinical outcome, were evaluated. Nine were male and 7 were female patients; mean age was 42 years (range, 3 to 68 y). Primary tumors arose on the leg in 5 patients, buttock in 1, trunk in 3, shoulder in 3, neck in 2, and finger in 1. The primary site in 1 case was unknown. Fifteen primary tumors available for review involved the dermis; 6 extended into the superficial subcutis. Tumor size ranged from 1 to 5 cm (median 3.2 cm). Histologically, primary tumors showed characteristic features of FH, being composed in most cases of a polymorphous population of bland spindle and histiocytoid cells in a mixed storiform and fascicular growth pattern with admixed foam cells, multinucleate cells, and inflammatory cells in varying proportions. Histologic variants included 11 cellular (2 with mixed atypical and cellular features), 2 aneurysmal, 1 atypical, and 1 epithelioid type. All tumors showed entrapment of hyalinized collagen bundles. Mitotic activity ranged from <1 to 13/10 HPF. Focal necrosis was seen in 1 primary tumor. Ten patients had local tumor recurrence; 4 patients  had multiple local recurrences. Time to first recurrence ranged from 6 weeks to 13 years. The local recurrences of 1 tumor showed increased cytologic atypia, but recurrences were otherwise morphologically similar to primary tumors. Metastases  occurred 0 to 180 months after diagnosis (median 17 mo) and involved the lungs (12 patients), lymph nodes (8), soft tissues (6), and liver (1). Five patients developed multiple satellite nodules in the region of the primary tumor. Metastases were morphologically similar to the primary tumors. So far, 6 patients died of disease, with a median time to death of 64 months (range, 10 to 168 mo).  Four patients are alive with metastatic disease. Two patients are disease free at last follow-up, and 1 patient died of unrelated disease. Metastasis of morphologically benign cutaneous FH is an extremely rare but clinically aggressive event. Primary tumors tend to be large and cellular, but aggressive behavior cannot be predicted on morphologic grounds alone; however, early or frequent local recurrence may warrant closer clinical follow-up.

 

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[54]

TÍTULO / TITLE:  - Agreement Among RTOG Sarcoma Radiation Oncologists in Contouring Suspicious Peritumoral Edema for Preoperative Radiation Therapy of Soft Tissue Sarcoma of the Extremity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Radiat Oncol Biol Phys. 2013 Mar 5. pii: S0360-3016(13)00128-4. doi: 10.1016/j.ijrobp.2013.01.032.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijrobp.2013.01.032

AUTORES / AUTHORS:  - Bahig H; Roberge D; Bosch W; Levin W; Petersen I; Haddock M; Freeman C; Delaney TF; Abrams RA; Indelicato DJ; Baldini EH; Hitchcock Y; Kirsch DG; Kozak KR; Wolfson A; Wang D

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology Centre Hospitalier de l’Universite de Montreal,  Montreal, QC, Canada.

RESUMEN / SUMMARY:  - PURPOSE: Peritumoral edema may harbor sarcoma cells. The extent of suspicious edema (SE) included in the treatment volume is subject to clinical judgment, balancing the risk of missing tumor cells with excess toxicity. Our goal was to determine variability in SE delineation by sarcoma radiation oncologists (RO). METHODS AND MATERIALS: Twelve expert ROs were provided with T1 gadolinium and T2-weighted MR images of 10 patients with high-grade extremity soft-tissue sarcoma. Gross tumor volume, clinical target volume (CTV)3cm (3 cm longitudinal and 1.5 cm radial margin), and CTV2cm (2 cm longitudinal and 1 cm radial margin)  were contoured by a single observer. Suspicious peritumoral edema, defined as abnormal signal on T2 images, was independently delineated by all 12 ROs. Contouring agreement was analyzed using the simultaneous truth and performance level estimation (STAPLE) algorithm and kappa statistics. RESULTS: The mean volumes of GTV, CTV2cm, and CTV3cm were, respectively, 130 cm3 (7-413 cm3), 280 cm3 and 360 cm3. The mean consensus volume computed using the STAPLE algorithm at 95% confidence interval was 188 cm3 (24-565 cm3) with a substantial overall agreement corrected for chance (mean kappa = 0.71; range: 0.32-0.87). The minimum, maximum, and mean volume of SE (excluding the GTV) were 4, 182, and 58 cm3 (representing a median of 29% of the GTV volume). The median volume of SE not included in the CTV2cm and in the CTV3cm was 5 and 0.3 cm3, respectively. There were 3 large tumors with >30 cm3 of SE not included in the CTV3cm volume. CONCLUSION: Despite the fact that SE would empirically seem to be a more subjective volume, a substantial or near-perfect interobserver agreement was observed in SE delineation in most cases with high-grade soft-tissue sarcomas of  the extremity. A median of 97% of the consensus SE is within the CTV2cm (99.8% within the CTV3cm). In a minority of cases, however, significant expansion of the CTVs is required to cover SE.

 

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[55]

TÍTULO / TITLE:  - Strontium ranelate prevents the deleterious action of advanced glycation endproducts on osteoblastic cells via calcium channel activation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Pharmacol. 2013 Mar 13;706(1-3):41-47. doi: 10.1016/j.ejphar.2013.02.042.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejphar.2013.02.042

AUTORES / AUTHORS:  - Fernandez JM; Molinuevo MS; Sedlinsky C; Schurman L; Cortizo AM; McCarthy AD

INSTITUCIÓN / INSTITUTION:  - Laboratorio de Investigacion en Osteopatias y Metabolismo Mineral, Facultad de Ciencias Exactas, Universidad Nacional de La Plata. 47 y 115, (1900) La Plata, Argentina.

RESUMEN / SUMMARY:  - Accumulation of advanced glycation endproducts (AGEs) in bone tissue occurs in ageing and in Diabetes mellitus, and is partly responsible for the increased risk of low-stress bone fractures observed in these conditions. In this study we evaluated whether the anti-osteoporotic agent strontium ranelate can prevent the  deleterious effects of AGEs on bone cells, and possible mechanisms of action involved. Using mouse MC3T3E1 osteoblastic cells in culture we evaluated the effects of 0.1mM strontium ranelate and/or 100mug/ml AGEs-modified bovine serum albumin (AGEs-BSA) on cell proliferation, osteogenic differentiation and pro-inflammatory cytokine production. We found that AGEs-BSA alone decreased osteoblastic proliferation and differentiation (P<0.01) while increasing IL-1beta and TNFalpha production (P<0.01). On its own, strontium ranelate induced opposite effects: an increase in osteoblast proliferation and differentiation (P<0.01) and a decrease in cytokine secretion (P<0.01). Additionally, strontium ranelate prevented the inhibitory and pro-inflammatory actions of AGEs-BSA on osteoblastic cells (P<0.01). These effects of strontium ranelate were blocked by co-incubation with either the MAPK inhibitor PD98059, or the calcium channel blocker nifedipine. We also evaluated by Western blotting the activation status of ERK (a MAPK) and b-catenin. Activation of both signaling pathways was decreased by AGEs  treatment, and this inhibitory effect was prevented if AGEs were co-incubated with strontium ranelate (P<0.01). On its own, strontium ranelate increased both pERK and activated b-catenin levels. In conclusion, this study demonstrates that  strontium ranelate can prevent the deleterious in vitro actions of AGEs on osteoblastic cells in culture by mechanisms that involve calcium channel, MAPK and b-catenin activation.

 

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[56]

TÍTULO / TITLE:  - Zoledronic acid negatively affects the expansion of in vitro activated human NK cells and their cytolytic interactions with Ewing sarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Rep. 2013 Mar 19. doi: 10.3892/or.2013.2350.

            ●● Enlace al texto completo (gratuito o de pago) 3892/or.2013.2350

AUTORES / AUTHORS:  - Mueller SK; Altvater B; Chen C; Kailayangiri S; Ahlmann M; Dirksen U; Juergens H; Rossig C

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Hematology and Oncology, University Children’s Hospital Muenster, Muenster, Germany.

RESUMEN / SUMMARY:  - Disseminated Ewing sarcoma remains a fatal disease despite advanced multimodal treatment regimens. Immunotherapies as well as novel drugs and biologicals are currently being explored to eliminate minimal residual disease after conventional therapy thereby rescuing patients at a high risk for relapse. Insights into the interactions between novel therapies provide the basis for the development of effective combination strategies. We investigated the effects of the aminobisphosphonate zoledronic acid (ZA) on the in vitro expansion of human natural killer (NK) cells and their cytolytic activity against Ewing sarcoma cells. ZA significantly impaired the in vitro expansion of activated NK cells from both healthy donors and Ewing sarcoma patients in a dose-dependent manner. Expression of differentiation markers and activating receptors was unaffected by  the drug. Activated NK cells from both healthy donors and patients had potent degranulation responses to Ewing sarcoma cells. In the presence of ZA at concentrations reflecting pharmaceutical serum levels, the in vitro antitumor activity of NK cells from Ewing sarcoma patients was significantly impaired. We conclude that ZA can impede in vitro NK cell expansion and cytolytic NK cell responses to Ewing sarcoma. These observations raise caution against the combination of adoptive NK cell transfer with ZA maintenance therapy in Ewing sarcoma. Future studies aim to identify potentiating interactions of novel drugs  with cellular therapies.

 

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[57]

TÍTULO / TITLE:  - Expression of microRNA-30c and its target genes in human osteoblastic cells by nano-bioglass ceramic-treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Biol Macromol. 2013 May;56:181-5. doi: 10.1016/j.ijbiomac.2013.02.017. Epub 2013 Mar 1.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijbiomac.2013.02.017

AUTORES / AUTHORS:  - Moorthi A; Vimalraj S; Avani C; He Z; Partridge NC; Selvamurugan N

INSTITUCIÓN / INSTITUTION:  - Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India.

RESUMEN / SUMMARY:  - Osteoblast differentiation is tightly regulated by post transcriptional regulators such as microRNAs (miRNAs). Several bioactive materials including nano-bioglass ceramic particles (nBGC) influence differentiation of the osteoblasts, but the molecular mechanisms of nBGC-stimulation of osteoblast differentiation via miRNAs are not yet determined. In this study, we identified that nBGC-treatment stimulated miR-30c expression in human osteoblastic cells (MG63). The bioinformatics tools identified its regulatory network, molecular function, biological processes and its target genes involved in negative regulation of osteoblast differentiation. TGIF2 and HDAC4 were found to be its putative target genes and their expression was down regulated by nBGC-treatment in MG63 cells. Thus, this study advances our understanding of nBGC action on bone cells and supports utilization of nBGC in bone tissue engineering.

 

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[58]

TÍTULO / TITLE:  - Long-lasting Clinical Benefit of Sunitinib Malate in the Treatment of a Case of Heavily Pre-treated Metastatic Liposarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anticancer Res. 2013 Mar;33(3):1061-3.

AUTORES / AUTHORS:  - Porzio R; Bella MA; Rossi G; Ardizzoni A

INSTITUCIÓN / INSTITUTION:  - Medical Oncology Unit, University Hospital of Parma, Via Gramsci 14, 43126 Parma, Italy. rosa.porzio@libero.it.

RESUMEN / SUMMARY:  - BACKGROUND: Soft tissue sarcomas are a heterogeneous group of malignant neoplasms including several distinct entities with different cell differentiation and clinical prognosis, but which are often treated as a single disease. Case Report: We report the case of a male patient, heavily treated for a metastatic well-differentiated liposarcoma occurring in the left lateral neck. He received radiotherapy and different lines of standard chemotherapy with local progression  and lung metastasis. In November 2009, on the basis of a phase II study demonstrating the efficacy of sunitinib in patients with liposarcoma, the patient was treated with sunitinib at 37.5 mg daily in 4-week cycles on a compassionate use basis. Until November 2012 he received a total of 23 cycles of sunitinib treatment achieving a stable disease in all sites. Therapy with sunitinib is still ongoing without side effects. CONCLUSION: Our findings confirm that sunitinib may be a useful therapeutic tool in the treatment of some cases of pre-treated liposarcoma.

 

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[59]

TÍTULO / TITLE:  - Secondary mutations of c-KIT contribute to acquired resistance to imatinib and decrease efficacy of sunitinib in Chinese patients with gastrointestinal stromal  tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Jun;30(2):522. doi: 10.1007/s12032-013-0522-y. Epub 2013 Mar 2.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-013-0522-y

AUTORES / AUTHORS:  - Gao J; Tian Y; Li J; Sun N; Yuan J; Shen L

INSTITUCIÓN / INSTITUTION:  - Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Peking University Cancer Hospital and Institute, No. 52, Fucheng Road, Haidian District, Beijing 100142, China.

RESUMEN / SUMMARY:  - The aim of this study was to investigate the associations between secondary mutations of c-KIT/PDGFRalpha and acquired imatinib resistance or efficacy of sunitinib in Chinese patients with gastrointestinal stromal tumors (GISTs). Mutations of c-KIT (exons 9, 11, 13, 14, 17, and 18) and PDGFRalpha (exons 12 and 18) in tumor samples of 50 patients were analyzed by direct sequencing. A total of 50 samples before imatinib and 52 samples after imatinib were collected. Among 52 samples after imatinib, 38 samples were imatinib resistant and 14 samples were imatinib sensitive. All patients before imatinib treatment had primary mutations  of c-KIT exon 11 (n = 45) or exon 9 (n = 5), and no PDGFRalpha mutations were found in these patients. After imatinib treatment, 25 of 38 (65.8 %) resistant tumors had secondary mutations in c-KIT exon 13 (n = 10), exon 14 (n = 1), exon 17 (n = 12) and exon 18 (n = 2), while no secondary mutations of c-KIT were found in 14 sensitive tumors (P < 0.001), indicating the close association of c-KIT secondary mutations with imatinib-acquired resistance. In our study, 19 patients  received sunitinib treatment after the failure of imatinib, and it seemed that the median progression-free survival (7 vs. 19 months, P = 0.244) in patients with secondary mutations (n = 13) was lower than that in patients without secondary mutations (n = 6). Secondary mutations of c-KIT were significantly associated with acquired resistance to imatinib in Chinese GIST patients, and whether secondary mutations of c-KIT could influence the efficacy of sunitinib needed to be further investigated.

 

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[60]

TÍTULO / TITLE:  - Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochem Pharmacol. 2013 Mar 1. pii: S0006-2952(13)00146-9. doi: 10.1016/j.bcp.2013.02.023.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bcp.2013.02.023

AUTORES / AUTHORS:  - Cassinelli G; Lanzi C; Tortoreto M; Cominetti D; Petrangolini G; Favini E; Zaffaroni N; Pisano C; Penco S; Vlodavsky I; Zunino F

INSTITUCIÓN / INSTITUTION:  - Molecular Pharmacology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

RESUMEN / SUMMARY:  - The activity of heparanase is responsible for heparan sulfate cleavage, thus resulting in the release of heparan sulfate-bound growth factors. Since heparanase activity is upregulated in several tumor types and is implicated in the malignant behavior, the enzyme is regarded as a promising target for antitumor therapy. Based on previous evidence that the heparanase inhibitor SST0001, a non-anticoagulant N-acetylated glycol split heparin, is effective against an Ewing’s sarcoma model, the present study was performed to extend the preclinical evaluation of SST0001 to a panel of pediatric sarcoma models, representative of various tumor histotypes (soft tissue and bone sarcomas) and to further elucidate its mode of action. SST0001 treatment downregulated several angiogenic factors in the conditioned media of sarcoma cells, inhibited the pro-invasive effect of heparin-binding factors (VEGF, bFGF, HGF, PDGF), and abrogated PDGF receptor tyrosine phosphorylation. Subcutaneous administration of  SST0001 was very effective, resulting in a significant growth inhibition (range,  64-95%) of all tested tumor xenografts. The efficacy of SST0001 was enhanced in combination with antiangiogenic agents (bevacizumab, sunitinib) as documented by  the high rate of complete response. The synergistic effect of SST0001 in combination with antiangiogenic agents is consistent with the heparanase mode of  action and with the relevant role of heparin-binding proangiogenic/growth factors in the malignant behavior of sarcoma cells.

 

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[61]

TÍTULO / TITLE:  - Retract-ligate-unroof-biopsy: a novel approach to the diagnosis and therapy of large nonpedunculated stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gastrointest Endosc. 2013 Jan 29. pii: S0016-5107(12)02972-0. doi: 10.1016/j.gie.2012.11.024.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.gie.2012.11.024

AUTORES / AUTHORS:  - Binmoeller KF; Shah JN; Bhat YM; Kane SD

INSTITUCIÓN / INSTITUTION:  - Paul May and Frank Stein Interventional Endoscopy Center, California Pacific Medical Center, San Francisco, California, USA.

RESUMEN / SUMMARY:  - BACKGROUND: We report a novel technique of retract-ligate-unroof-biopsy (RLUB) for the diagnosis and treatment of large nonpedunculated upper GI stromal tumors  originating from the muscularis propria. OBJECTIVE: Proof-of-concept evaluation of the RLUB technique. DESIGN: Pilot and feasibility study. SETTING: Tertiary care center. PATIENTS: Sixteen patients (median age 71 years) fulfilling the following inclusion criteria: poor surgical candidates with lesions that are broad based with a benign appearance, originating from the muscularis propria, size 2 cm or larger. INTERVENTIONS: A double-channel endoscope was used to simultaneously retract the stromal tumor while advancing an endoloop beyond the tumor for ligation. The overlying tissue was incised (“unroofed”) to expose and partially enucleate the tumor, and multiple biopsy samples were obtained. After unroofing, an additional endoloop was placed below the previous one by using the  loop-over-loop technique to reinforce enucleation and ischemic ablation. MAIN OUTCOME MEASUREMENTS: Successful ligation, immunohistochemistry and mitotic index yield, therapeutic ablation, adverse events. RESULTS: Technical success was achieved in 13 of 16 patients (81%). Immunohistology of biopsy specimens: GI stromal tumor (n = 10), leiomyoma (n = 3). Twelve of 13 patients (92%) with follow-up (median 22 weeks, range 1-82.5 weeks) had confirmed tumor ablation by endoscopy and EUS. One patient with partial resolution was re-treated, but was subsequently lost to follow-up. Delayed bleeding occurred in 2 patients that required hospitalization and blood transfusions, both successfully controlled with repeat endolooping. One patient reported transient pain. LIMITATIONS: Single center, single operator, small sample size. CONCLUSIONS: The RLUB technique is feasible as a platform for full-thickness treatment of stromal tumors. Limitations encountered included technical challenges and delayed bleeding. Further developmental work is needed.

 

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[62]

TÍTULO / TITLE:  - Analysis of orbital plain radiographs for orbital deformities in neurofibromatosis type 1 patients, with special reference to alterations of the orbital rim as indicators of adjacent plexiform neurofibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anticancer Res. 2013 Mar;33(3):1081-90.

AUTORES / AUTHORS:  - Friedrich RE; Rother J; Christ G; Lehmann M; Eulenburg CG; Giese M; Scheuer HA

INSTITUCIÓN / INSTITUTION:  - DMD, NF Laboratory, Lottestr. 55, D-22529 Hamburg, Germany. rfriedrich@uke.de.

RESUMEN / SUMMARY:  - Neurofibromatosis type 1 (NF1) is an autosomal dominant inherited disease. Some stigmata of NF1 occur in the orbital region. The aim of this study was to reveal  whether alterations of the orbital rim visible on plain radiographs may indicate  the presence of a plexiform neurofibroma (PNF), a tumour almost exclusively diagnosed in NF1. MATERIAL AND METHODS: The plain orbital radiographs of 73 patients with NF1 (female: N=37, male: N=36) were investigated for alterations of the orbit. The group was further distinguished according to the presence of orbital PNF (N=53) and/or sphenoid wing dysplasia (N=30). Radiographs from patients with NF1 and with exclusion of PNF in the orbitofacial region were used  for comparison (N=20). A special cephalometric analysis (Dental Vision) was adapted to the demands of this study. RESULTS: Patients with NF1 not affected by  an orbitofacial PNF exhibited symmetrical orbits. Unilateral increase in orbital  height was associated with ipsilateral PNF. The width of orbits affected by a PNF was often slightly increased compared to the non-affected side. The determination of cephalometrically-defined angles disclosed an erection of the PNF-affected orbit compared to the medio-sagittal plane. CONCLUSION: Plain radiographs are often the first diagnostic measure used to determine skeletal alterations. This study shows that certain parameters of the orbital rim are useful indicators of a PNF in patients who are unilaterally affected by this lesion in the orbital or orbitotemporal region.

 

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[63]

TÍTULO / TITLE:  - Osteochondroma of the right coronoid process (Jacob disease): a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cranio. 2013 Jan;31(1):66-9.

AUTORES / AUTHORS:  - Aoki N; Okamura K; Niino D; Iwamoto O; Kusukawa J

INSTITUCIÓN / INSTITUTION:  - Dental and Oral Medical Center, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan. nobuko-aoki@hotmail.co.jp

RESUMEN / SUMMARY:  - Oscar Jacob was the first to describe osteochondroma of the coronoid process, naming it “Jacob disease.” Jacob disease rarely occurs in the oral and maxillofacial regions. The tumor usually grows progressively, leading to a mushroom-shaped enlargement of the process, and a joint-like structure is found between the coronoid process and the inner aspect of the zygomatic arch. Most of  these lesions grow like a mushroom on, and do not destroy, the coronoid process.  The major symptoms include restricted mouth opening and morphological changes to  the zygoma. The authors present a case report on an 18-year-old male patient with pain in the right zygoma. Interincisal maximum mouth opening was 51 mm. An intraoral coronoidectomy was performed.

 

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[64]

TÍTULO / TITLE:  - Total artificial heart support with two continuous-flow ventricular assist devices in a patient with an infiltrating cardiac sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - ASAIO J. 2013 Mar-Apr;59(2):178-80. doi: 10.1097/MAT.0b013e3182816cd9.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MAT.0b013e3182816cd9

AUTORES / AUTHORS:  - Pirk J; Maly J; Szarszoi O; Urban M; Kotulak T; Riha H; Neuzil P; Netuka I

INSTITUCIÓN / INSTITUTION:  - Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

RESUMEN / SUMMARY:  - Primary cardiac sarcoma is normally fatal, but cardiac replacement may provide some hope for long-term survival. A 38 year-old man with cardiac sarcoma, involving the interventricular septum and posterior wall with intermittent mitral obstruction, underwent implantation of two HeartMate II ventricular assist devices for total artificial heart support. After cardiectomy, the HeartMate sewing rings were sewn to the right neoatrium and the left atrial remnants. After the outflow grafts were sewn end to end to the pulmonary artery and aorta, the two drivelines were externalized through the abdominal wall, and perfusion started. The postoperative course was complicated by respiratory and renal dysfunction, which resolved. After 6 months of support, the patient has normal organ function and is ambulatory. Follow-up oncologic evaluation of positron emission tomography-computed tomography scan is negative.

 

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[65]

TÍTULO / TITLE:  - Phase 2 study of preoperative image-guided intensity-modulated radiation therapy  to reduce wound and combined modality morbidities in lower extremity soft tissue  sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer. 2013 Feb 19. doi: 10.1002/cncr.27951.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cncr.27951

AUTORES / AUTHORS:  - O’Sullivan B; Griffin AM; Dickie CI; Sharpe MB; Chung PW; Catton CN; Ferguson PC; Wunder JS; Deheshi BM; White LM; Kandel RA; Jaffray DA; Bell RS

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.

RESUMEN / SUMMARY:  - BACKGROUND: This study sought to determine if preoperative image-guided intensity-modulated radiotherapy (IG-IMRT) can reduce morbidity, including wound  complications, by minimizing dose to uninvolved tissues in adults with lower extremity soft tissue sarcoma. METHODS: The primary endpoint was the development  of an acute wound complication (WC). IG-IMRT was used to conform volumes to avoid normal tissues (skin flaps for wound closure, bone, or other uninvolved soft tissues). From July 2005 to June 2009, 70 adults were enrolled; 59 were evaluable for the primary endpoint. Median tumor size was 9.5 cm; 55 tumors (93%) were high-grade and 58 (98%) were deep to fascia. RESULTS: Eighteen (30.5%) patients developed WCs. This was not statistically significantly different from the result of the National Cancer Institute of Canada SR2 trial (P = .2); however, primary closure technique was possible more often (55 of 59 patients [93.2%] versus 50 of 70 patients [71.4%]; P = .002), and secondary operations for WCs were somewhat reduced (6 of 18 patients [33%] versus 13 of 30 patients [43%]; P = .55). Moderate edema, skin, subcutaneous, and joint toxicity was present in 6 (11.1%),  1 (1.9%), 5 (9.3%), and 3 (5.6%) patients, respectively, but there were no bone fractures. Four local recurrences (6.8%, none near the flaps) occurred with median follow-up of 49 months. CONCLUSIONS: The 30.5% incidence of WCs was numerically lower than the 43% risk derived from the National Cancer Institute of Canada SR2 trial, but did not reach statistical significance. Preoperative IG-IMRT significantly diminished the need for tissue transfer. RT chronic morbidities and the need for subsequent secondary operations for WCs were lowered, although not significantly, whereas good limb function was maintained. Cancer 2013. Esta es una cita bibliográfica que va por delante de la publicación en papel. La fecha indicada en la cita provista, NO corresponde con la fecha o la cita bibliográfica de la publicación en papel. La cita bibliográfica definitiva (con el volumen y su paginación) saldrá en 1 ó 2 meses a partir de la fecha de la emisión electrónica-online. *** This is a bibliographic record ahead of the paper publication. The given date in the bibliographic record does not correspond to the date or the bibliographic citation on the paper publication. The publisher will provide the final bibliographic citation (with the volume, and pagination) within 1 or 2 months from the date the record was published online. © 2013 American Cancer Society.

 

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[66]

TÍTULO / TITLE:  - Tumor response and clinical outcome in metastatic gastrointestinal stromal tumors under sunitinib therapy: Comparison of RECIST, Choi and volumetric criteria.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Radiol. 2013 Mar 18. pii: S0720-048X(13)00122-8. doi: 10.1016/j.ejrad.2013.02.034.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejrad.2013.02.034

AUTORES / AUTHORS:  - Schramm N; Englhart E; Schlemmer M; Hittinger M; Ubleis C; Becker CR; Reiser MF; Berger F

INSTITUCIÓN / INSTITUTION:  - Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich,  Marchioninistrasse 15, 81377 Munich, Germany. Electronic address: Nicolai.schramm@med.uni-muenchen.de.

RESUMEN / SUMMARY:  - PURPOSE: Purpose of the study was to compare radiological treatment response according to RECIST, Choi and volumetry in GIST-patients under 2nd-line-sunitinib-therapy and to correlate the results of treatment response assessment with disease-specific survival (DSS). PATIENTS AND METHODS: 20 patients (mean: 60.7 years; 12 male/8 female) with histologically proven GIST underwent baseline-CT of the abdomen under imatinib and follow-up-CTs 3 months and 1 year after change to sunitinib. 68 target lesions (50 hepatic, 18 extrahepatic) were investigated. Therapy response (partial response (PR), stable  disease (SD), progressive disease (PD)) was evaluated according to RECIST, Choi and volumetric criteria. Response according to the different assessment systems was compared and correlated to the DSS of the patients utilizing Kaplan-Meier statistics. RESULTS: The mean DSS (in months) of the response groups 3 months after therapy change was: RECIST: PR (0/20); SD (17/20): 30.4 (months); PD (3/20) 11.6. Choi: PR (10/20) 28.6; SD (8/20) 28.1; PD (2/20) 13.5. Volumetry: PR (4/20) 29.6; SD (11/20) 29.7; PD (5/20) 17.2. Response groups after 1 year of sunitinib  showed the following mean DSS: RECIST: PR (3/20) 33.6; SD (9/20) 29.7; PD (8/20)  20.3. Choi: PR (10/20) 21.5; SD (4/20) 42.9; PD (6/20) 23.9. Volumetry: PR (6/20) 27.3; SD (5/20) 38.5; PD (9/20) 19.3. CONCLUSION: One year after modification of  therapy, only partial response according to RECIST indicated favorable survival in patients with GIST. The value of alternate response assessment strategies like Choi criteria for prediction of survival in molecular therapy still has to be demonstrated.

 

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[67]

TÍTULO / TITLE:  - Cooperation between osteoblastic cells and endothelial cells enhances their phenotypic responses and improves osteoblast function.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biotechnol Lett. 2013 Mar 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10529-013-1170-1

AUTORES / AUTHORS:  - Dariima T; Jin GZ; Lee EJ; Wall IB; Kim HW

INSTITUCIÓN / INSTITUTION:  - Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 330714, Republic of Korea.

RESUMEN / SUMMARY:  - Osteogenesis requires close co-operation with angiogenesis to create vascularized bone tissue. In this study, an indirect co-culture model using osteoblasts (OBs), primary endothelial cells (ECs) and Matrigel interlayer was established to understand the impact of each cell type on the other. ECs synergistically enhanced osteoblastic gene expression by OBs, while OBs were capable of supporting tubule-like structures formed by ECs on Matrigel, enhancing mean tubule length from 146.5 +/- 23.5 mum in ECs alone to 192 +/- 28.6 mum in co-culture (p < 0.05). Similar improvements were noted in terms of tubule number. An applicability study of the co-culture model to bone tissue engineering, performed on a biopolymer fibrous membrane, showed substantially enhanced deposition of calcified nodules. These results demonstrate the efficacy of co-culture with ECs to improve osteogenesis for bone tissue engineering.

 

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[68]

TÍTULO / TITLE:  - Primary Angiosarcoma of Bone: A Retrospective Analysis of 60 Patients From 2 Institutions.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Clin Oncol. 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 1097/COC.0b013e31827defa1

AUTORES / AUTHORS:  - Palmerini E; Maki RG; Staals EL; Alberghini M; Antonescu CR; Ferrari C; Ruggieri P; Mavrogenis A; Bertoni F; Cesari M; Paioli A; Marchesi E; Picci P; Ferrari S

INSTITUCIÓN / INSTITUTION:  - Departments of *Chemotherapy double daggerOrthopaedic Surgery section signSurgical Pathology paragraph signResearch Laboratory, Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, Bologna, Italy Departments of daggerMedicine parallelPathology, Memorial Sloan-Kettering Cancer Center, New York, NY.

RESUMEN / SUMMARY:  - BACKGROUND:: Angiosarcoma of bone is a rare high-grade malignant vascular tumor.  The literature regarding treatment and outcome of patients with this tumor is limited.We performed a 2 institutional retrospective study to analyze treatment and survival of patients with angiosarcoma of bone. PATIENTS AND METHODS:: We reviewed patients with the histologic diagnosis of primary angiosarcoma of bone treated from 1980 to 2009. Demographic details, histology, treatment, and survival were reviewed. RESULTS:: A total of 38 men and 22 women (median age, 54  y) were recruited. Most lesions occurred in the femur and the pelvis. Metastatic  disease at presentation was diagnosed in 24 patients (40%). Forty-three patients  underwent surgery, with 30 of them achieving surgical complete remission (SCR). Radiotherapy was applied to 17 patients, and chemotherapy to 13/35 and 15/22 patients with localized and metastatic disease, respectively.The 5-year overall survival (OS) was 20%: 33% for patients with localized disease and 0% for metastatic patients. Higher 5-year OS was reported for patients who achieved SCR  (46%) than for those who did not (0%). In nonmetastatic patients, a trend toward  improved survival was observed after SCR and adjuvant chemotherapy based on cisplatin, doxorubicin, and ifosfamide.Fifteen patients received chemotherapy for metastases. Two RECIST partial responses of 13 evaluable patients were documented [paclitaxel (n=1) and doxorubicin (n=1)]. Stable disease was observed in 2 patients. CONCLUSIONS:: Complete surgical resection is essential for outcome. Survival of patients with metastatic or unresectable disease is very poor. Activity of taxanes and anthracycline was observed in the metastatic setting and  merits further evaluation.

 

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[69]

TÍTULO / TITLE:  - Sinonasal Disease in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Laryngoscope. 2013 Apr;123(4):823-8. doi: 10.1002/lary.23758. Epub 2013 Feb 26.

            ●● Enlace al texto completo (gratuito o de pago) 1002/lary.23758

AUTORES / AUTHORS:  - Deklotz TR; Kim HJ; Kelly M; Collins MT

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology-Head and Neck Surgery, Georgetown University Hospital, Washington, D.C., U.S.A.

RESUMEN / SUMMARY:  - OBJECTIVES/HYPOTHESIS: To characterize the spectrum, symptoms, progression, and effects of endocrine dysfunction on sinonasal disease in polyostotic fibrous dysplasia (PFD) and McCune-Albright Syndrome (MAS). STUDY DESIGN: Retrospective review. METHODS: A prospectively followed cohort of subjects with PFD/MAS underwent a comprehensive evaluation that included otolaryngologic and endocrine  evaluation, and imaging studies. Head and facial computed tomography scans were analyzed, and the degree of fibrous dysplasia (FD) was graded using a modified Lund-MacKay scale. Those followed for >4 years were analyzed for progression. RESULTS: A total of 106 patients meeting inclusion criteria were identified with  craniofacial FD. A majority (92%) demonstrated sinonasal involvement. There were  significant positive correlations between the sinonasal FD scale score and chronic congestion, hyposmia, growth hormone excess, and hyperthyroidism (P < .05 for all). Significant correlations were not found for headache/facial pain or recurrent/chronic sinusitis. Thirty-one subjects met the criteria for longitudinal analysis (follow-up mean, 6.3 years; range, 4.4-9 years). Those who  demonstrated disease progression were significantly younger than those who did not (mean age, 11 vs. 25 years). Progression after age of 13 years was uncommon (n = 3) and minimal. Concomitant endocrinopathy or bisphosphonate use did not have any significant effect on progression of disease. CONCLUSIONS: Sinonasal involvement of fibrous dysplasia in PFD/MAS is common. Symptoms are usually few and mild, and disease progression occurs primarily in young subjects. Concomitant endocrinopathy is associated with disease severity, but not progression.

 

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[70]

TÍTULO / TITLE:  - Growth rate of late passage sarcoma cells is independent of epigenetic events but dependent on the amount of chromosomal aberrations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Cell Res. 2013 Mar 25. pii: S0014-4827(13)00131-6. doi: 10.1016/j.yexcr.2013.03.023.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.yexcr.2013.03.023

AUTORES / AUTHORS:  - Becerikli M; Jacobsen F; Rittig A; Kohne W; Nambiar S; Mirmohammadsadegh A; Stricker I; Tannapfel A; Wieczorek S; Epplen JT; Tilkorn D; Steinstraesser L

INSTITUCIÓN / INSTITUTION:  - Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr-University Bochum, Germany.

RESUMEN / SUMMARY:  - Soft tissue sarcomas (STS) are characterized by co-participation of several epigenetic and genetic events during tumorigenesis. Having bypassed cellular senescence barriers during oncogenic transformation, the factors further affecting growth rate of STS cells remain poorly understood. Therefore, we investigated the role of gene silencing (DNA promoter methylation of LINE-1, PTEN), genetic aberrations (karyotype, KRAS and BRAF mutations) as well as their  contribution to the proliferation rate and migratory potential that underlies “initial” and “final” passage sarcoma cells. Three different cell lines were used, SW982 (synovial sarcoma), U2197 (malignant fibrous histiocytoma (MFH)) and  HT1080 (fibrosarcoma). Increased proliferative potential of final passage STS cells was not associated with significant differences in methylation (LINE-1, PTEN) and mutation status (KRAS, BRAF), but it was dependent on the amount of chromosomal aberrations. Collectively, our data demonstrate that these fairly differentiated/advanced cancer cell lines have still the potential to gain an additional spontaneous growth benefit without external influences and that maintenance of increased proliferative potential towards longevity of STS cells (having crossed senescence barriers) may be independent of overt epigenetic alterations.

 

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[71]

TÍTULO / TITLE:  - External validation of a prognostic nomogram for overall survival in women with uterine leiomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer. 2013 Mar 1. doi: 10.1002/cncr.27971.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cncr.27971

AUTORES / AUTHORS:  - Iasonos A; Keung EZ; Zivanovic O; Mancari R; Peiretti M; Nucci M; George S; Colombo N; Carinelli S; Hensley ML; Raut CP

INSTITUCIÓN / INSTITUTION:  - Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York. iasonosa@mskcc.org.

RESUMEN / SUMMARY:  - BACKGROUND: There is no validated system to identify prognostically distinct cohorts of women with uterine leiomyosarcoma (ULMS). By using an independent, pooled, multi-institutional, international patient cohort, the authors validated  a recently proposed ULMS nomogram. METHODS: The ULMS nomogram incorporated 7 clinical characteristics (age, tumor size, tumor grade, cervical involvement, locoregional metastases, distant metastases, and mitotic index (per 10 high-power fields) to predict overall survival (OS) after primary surgery. Independent cohorts from 2 sarcoma centers were included. Eligible women, at minimum, underwent a hysterectomy for primary, locally advanced, or metastatic ULMS and received part of their care at 1 of the centers between 1994 and 2010. RESULTS: In total, 187 women with ULMS were identified who met the above criteria described above (median age, 51 years; median tumor size, 9 cm; median mitotic index, 20 per 10 high-power fields). Tumors generally were high grade (88%), FIGO stage I or II (61%) without cervical involvement (93%) and without locoregional metastases (77%) or distant metastases (83%). The median OS and the 5-year OS rate were 4.5 years (95% confidence interval, 3.2-5.3 years) and 46%, respectively; and 65 women (35%) remained alive at last follow-up. The nomogram concordance index was 0.67(standard error, 0.02), which was as high as the concordance index from the initial cohort used for nomogram development. The concordance between actual OS and nomogram predictions suggests excellent calibration because predictions were within 1% of actual 5-year OS rates for patients with a predicted 5-year OS of less than 0.68. CONCLUSIONS: The ULMS nomogram was externally validated using independent cohorts. These findings support the international use of the ULMS nomogram prognostic of OS in ULMS. Cancer 2012. Esta es una cita bibliográfica que va por delante de la publicación en papel. La fecha indicada en la cita provista, NO corresponde con la fecha o la cita bibliográfica de la publicación en papel. La cita bibliográfica definitiva (con el volumen y su paginación) saldrá en 1 ó 2 meses a partir de la fecha de la emisión electrónica-online. *** This is a bibliographic record ahead of the paper publication. The given date in the bibliographic record does not correspond to the date or the bibliographic citation on the paper publication. The publisher will provide the final bibliographic citation (with the volume, and pagination) within 1 or 2 months from the date the record was published online. © 2012 American Cancer Society.

 

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[72]

TÍTULO / TITLE:  - Congenital Kaposiform Hemangioendothelioma with Kasabach-Merritt Phenomenon Successfully Treated with Low-Dose Radiation Therapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Dermatol. 2013 Mar 5. doi: 10.1111/pde.12090.

            ●● Enlace al texto completo (gratuito o de pago) 1111/pde.12090

AUTORES / AUTHORS:  - Malhotra Y; Yang CS; McNamara J; Antaya RJ

INSTITUCIÓN / INSTITUTION:  - Division of Neonatology, Yale University, New Haven, Connecticut; Division of Neonatology, Maria Fareri Children’s Hospital, New York Medical College, Westchester, New York.

RESUMEN / SUMMARY:  - Kaposiform hemangioendothelioma (KHE) associated with Kasabach-Merritt phenomenon is a life-threatening vasculopathy. The current mainstay treatment for KHEs is corticosteroids and chemotherapy, but these medications do not work for all patients and carry significant side effects. We report a neonate with a large congenital KHE who responded extremely well to low-dose radiation therapy.

 

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[73]

TÍTULO / TITLE:  - Atrial myxoma mimicking a clot in transit.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Am Coll Cardiol. 2013 Apr 9;61(14):e159. doi: 10.1016/j.jacc.2012.07.081.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jacc.2012.07.081

AUTORES / AUTHORS:  - McCulloch MD; Smedira NG; Hawwa AG; Tan CD; Rodriguez LL

INSTITUCIÓN / INSTITUTION:  - Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

 

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[74]

TÍTULO / TITLE:  - Novel Dedifferentiated Liposarcoma Xenograft Models Reveal PTEN Down-Regulation as a Malignant Signature and Response to PI3K Pathway Inhibition.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Pathol. 2013 Apr;182(4):1400-11. doi: 10.1016/j.ajpath.2013.01.002. Epub 2013 Feb 12.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ajpath.2013.01.002

AUTORES / AUTHORS:  - Smith KB; Tran LM; Tam BM; Shurell EM; Li Y; Braas D; Tap WD; Christofk HR; Dry SM; Eilber FC; Wu H

INSTITUCIÓN / INSTITUTION:  - Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; Institute for Molecular Medicine, David Geffen School of Medicine, University of  California, Los Angeles, Los Angeles, California.

RESUMEN / SUMMARY:  - Liposarcoma is a type of soft tissue sarcoma that exhibits poor survival and a high recurrence rate. Treatment is generally limited to surgery and radiation, which emphasizes the need for better understanding of this disease. Because very  few in vivo and in vitro models can reproducibly recapitulate the human disease,  we generated several xenograft models from surgically resected human dedifferentiated liposarcoma. All xenografts recapitulated morphological and gene expression characteristics of the patient tumors after continuous in vivo passages. Importantly, xenograftability was directly correlated with disease-specific survival of liposarcoma patients. Thus, the ability for the tumor of a patient to engraft may help identify those patients who will benefit from more aggressive treatment regimens. Gene expression analyses highlighted the association between xenograftability and a unique gene expression signature, including down-regulated PTEN tumor-suppressor gene expression and a progenitor-like phenotype. When treated with the PI3K/AKT/mTOR pathway inhibitor  rapamycin alone or in combination with the multikinase inhibitor sorafenib, all xenografts responded with increased lipid content and a more differentiated gene  expression profile. These human xenograft models may facilitate liposarcoma research and accelerate the generation of readily translatable preclinical data that could ultimately influence patient care.

 

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[75]

TÍTULO / TITLE:  - Elevated TNFR1 and Serotonin in bone metastasis are correlated with poor survival following bone metastasis diagnosis for both carcinoma and sarcoma primary tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Cancer Res. 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1158/1078-0432.CCR-12-3416

AUTORES / AUTHORS:  - Chiechi A; Novello C; Magagnoli G; Petricoin EF 3rd; Deng J; Benassi MS; Picci P; Vaisman II; Espina V; Liotta LA

INSTITUCIÓN / INSTITUTION:  - Center for Applied Proteomics and Molecular Medicine, George Mason University.

RESUMEN / SUMMARY:  - PURPOSE: There is an urgent need for therapies that will reduce the mortality of  patients with bone metastasis. In this study we profiled the protein signal pathway networks of the human bone metastasis microenvironment. The goal was to identify sets of interacting proteins that correlate with survival time following the first diagnosis of bone metastasis. EXPERIMENTAL DESIGN: Using Reverse Phase  Protein Microarray technology we measured the expression of 88 end-points in the  bone microenvironment of 159 bone metastasis tissue samples derived from patients with primary carcinomas and sarcomas. RESULTS: Metastases originating from different primary tumors showed similar levels of cell signaling across tissue types for the majority of proteins analyzed, suggesting that the bone microenvironment strongly influences the metastatic tumor signaling profiles. In  a training set (72 samples), TNFR1, alone (p=0.0013) or combined with Serotonin (p=0.0004), TNFalpha (p=0.0214) and RANK (p=0.0226), was associated with poor survival, regardless of the primary tumor of origin. Results were confirmed by: a) analysis of an independent validation set (71 samples) and b) independent bioinformatic analysis using a support vector machine learning model. Spearman’s  rho analysis revealed a highly significant number of interactions intersecting with ERalpha S118, Serotonin, TNFalpha, RANKL and MMPs in the bone metastasis signaling network, regardless of the primary tumor. The interaction network pattern was significantly different in the short versus long survivors. CONCLUSIONS: TNFR1 and neuroendocrine-regulated protein signal pathways appear to play an important role in bone metastasis and may constitute a novel drug-targetable mechanism of seed-soil cross-talk in bone metastasis.

 

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[76]

TÍTULO / TITLE:  - Expression profiling of 519 kinase genes in matched malignant peripheral nerve sheath tumor/plexiform neurofibroma samples is discriminatory and identifies mitotic regulators BUB1B, PBK and NEK2 as overexpressed with transformation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mod Pathol. 2013 Feb 1. doi: 10.1038/modpathol.2012.242.

            ●● Enlace al texto completo (gratuito o de pago) 1038/modpathol.2012.242

AUTORES / AUTHORS:  - Stricker TP; Henriksen KJ; Tonsgard JH; Montag AG; Krausz TN; Pytel P

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, University of Chicago Medical Center, Chicago, IL, USA.

RESUMEN / SUMMARY:  - About 50% of all malignant peripheral nerve sheath tumors (MPNSTs) arise as neurofibromatosis type 1 associated lesions. In those patients malignant peripheral nerve sheath tumors are thought to arise through malignant transformation of a preexisting plexiform neurofibroma. The molecular changes associated with this transformation are still poorly understood. We sought to test the hypothesis that dysregulation of expression of kinases contributes to this malignant transformation. We analyzed expression of all 519 kinase genes in  the human genome using the nanostring nCounter system. Twelve cases of malignant  peripheral nerve sheath tumor arising in a background of preexisting plexiform neurofibroma were included. Both components were separately sampled. Statistical  analysis compared global changes in expression levels as well as changes observed in the pairwise comparison of samples taken from the same surgical specimen. Immunohistochemical studies were performed on tissue array slides to confirm expression of selected proteins. The expression pattern of kinase genes can separate malignant peripheral nerve sheath tumors and preexisting plexiform neurofibromas. The majority of kinase genes is downregulated rather than overexpressed with malignant transformation. The patterns of expression changes are complex without simple recurring alteration. Pathway analysis demonstrates that differentially expressed kinases are enriched for kinases involved in the direct regulation of mitosis, and several of these show increased expression in malignant peripheral nerve sheath tumors. Immunohistochemical studies for the mitotic regulators BUB1B, PBK and NEK2 confirm higher expression levels at the protein level. These results suggest that the malignant transformation of plexiform neurofibroma is associated with distinct changes in the expression of kinase genes. The patterns of these changes are complex and heterogeneous. There  is no single unifying alteration. Kinases involved in mitotic regulation are particularly enriched in the pool of differentially expressed kinases. Some of these are overexpressed and are therefore possible targets for kinase inhibitors.Modern Pathology advance online publication, 1 February 2013; doi:10.1038/modpathol.2012.242.

 

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[77]

TÍTULO / TITLE:  - Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bone. 2013 Feb 26. pii: S8756-3282(13)00087-2. doi: 10.1016/j.bone.2013.02.016.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bone.2013.02.016

AUTORES / AUTHORS:  - Mutsaers AJ; Ng AJ; Baker EK; Russell MR; Chalk AM; Wall M; Liddicoat BJ; Ho PW; Slavin JL; Goradia A; Martin TJ; Purton LE; Dickins RA; Walkley CR

INSTITUCIÓN / INSTITUTION:  - St. Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia.

RESUMEN / SUMMARY:  - Osteosarcoma is the most common primary cancer of bone and one that predominantly affects children and adolescents. Osteoblastic osteosarcoma represents the major  subtype of this tumor, with approximately equal representation of fibroblastic and chondroblastic subtypes. We and others have previously described murine models of osteosarcoma based on osteoblast-restricted Cre:lox deletion of Trp53 (p53) and Rb1 (Rb), resulting in a phenotype most similar to fibroblastic osteosarcoma in humans. We now report a model of the most prevalent form of human osteosarcoma, the osteoblastic subtype. In contrast to other osteosarcoma models  that have used Cre:lox mediated gene deletion, this model was generated through shRNA-based knockdown of p53. As is the case with the human disease the shRNA tumors most frequently present in the long bones and preferentially disseminate to the lungs; feature less consistently modeled using Cre:lox approaches. Our approach allowed direct comparison of the in vivo consequences of targeting the same genetic drivers using two different technologies, Cre:lox and shRNA. This demonstrated that the effects of Cre:lox and shRNA mediated knock-down are qualitatively different, at least in the context of osteosarcoma, and yielded distinct subtypes of osteosarcoma. Through the use of complementary genetic modification strategies we have established a model of the most common clinical subtype of osteosarcoma that was not previously represented and more fully recapitulated the clinical spectrum of this cancer.

 

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[78]

TÍTULO / TITLE:  - Secondary syphilis mimicking Kaposi sarcoma in an HIV patient.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Dermatol. 2013 Feb 1;23(1):120-1. doi: 10.1684/ejd.2012.1905.

            ●● Enlace al texto completo (gratuito o de pago) 1684/ejd.2012.1905

AUTORES / AUTHORS:  - Gori A; Maio V; Grazzini M; Rossari S; Papi F; Massi D; Giorgi L; Zuccati G; de Giorgi V

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology.

 

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[79]

TÍTULO / TITLE:  - Bone scintigraphy may help differentiate bone sclerotic lesions from osteoblastic metastases in tuberous sclerosis patients with concomitant pulmonary adenocarcinoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Mar;37(2):382-5. doi: 10.1016/j.clinimag.2012.06.004. Epub 2012 Jul 15.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.06.004

AUTORES / AUTHORS:  - Song L; Zhang Y; Zhang W

INSTITUCIÓN / INSTITUTION:  - The Department of Nuclear Medicine, Peking University Third Hospital, Beijing, The People’s Republic of China.

RESUMEN / SUMMARY:  - Tuberous sclerosis (TS) is a multisystem disorder characterized by widespread hamartomas in multiple organs, including the skeleton. We present a case of bone  involvement in a patient with TS and concomitant pulmonary adenocarcinoma. Bone scintigraphy is useful in distinguishing the TS bone lesions from osteoblastic metastases.

 

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[80]

TÍTULO / TITLE:  - Inflammatory fibroid polyps of the gastrointestinal tract: spectrum of clinical,  morphologic, and immunohistochemistry features.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2013 Apr;37(4):586-92. doi: 10.1097/PAS.0b013e31827ae11e.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e31827ae11e

AUTORES / AUTHORS:  - Liu TC; Lin MT; Montgomery EA; Singhi AD

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.

RESUMEN / SUMMARY:  - Inflammatory fibroid polyps (IFPs) are rare, benign tumors that can arise throughout the gastrointestinal tract. Although the molecular pathogenesis of these lesions has been well characterized, their morphologic features often vary. We report the clinicopathologic findings of the largest series of IFPs to date. A total of 83 IFPs seen at our institution were collected between 1999 and 2012. The specimens included 64 biopsies and 19 resections. A review of the clinical features identified a modest female predominance (47 women and 36 men) with patients ranging in age from 26 to 87 years (mean, 60 y). Involved sites included the esophagus (n=2), stomach (n=31; mainly antrum), small intestines (n=17), appendix (n=1), large intestines (n=31; majority within the rectosigmoid), and anal canal (n=1). Although most patients had a nonspecific presentation, those with small intestinal lesions frequently presented with intussusception. Grossly, the tumors ranged in size from 0.2 to 4.2 cm (mean, 1.7 cm). Histologically, IFPs were centered within the submucosa in all resection specimens, but mucosal extension was found in 74 of 83 (89%) cases. The tumors varied in both cellularity and degree of vascularity. However, the characteristic feature of perivascular onion skinning was present in only 54% (45/83) of the cases. In addition, a short fascicular growth pattern was also noted in 36% (30 of 83) of cases, whereas both features were present in 14 cases (17%). Eosinophils were present in 94% (78 of 83) of cases but varied widely in number from abundant (20/hpf) to sparse (1/hpf). Interestingly, in those cases with sparse eosinophils, prominent hyalinization was also present (11 of 78, 13%). In addition, although the majority of IFPs expressed CD34, 6 of 44 (14%) were negative. No associated dysplasia or malignancy was seen. IFPs represent a diverse set of submucosal-based lesions that commonly extend into the mucosa, making them amenable to endoscopic biopsy. Although their classic histologic features of perivascular onion skinning and predominance of eosinophils are well  described, they may alternatively present with a short fascicular growth pattern, a sparse number of eosinophils, and prominent hyalinization.

 

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[81]

TÍTULO / TITLE:  - Custom-made wrist prosthesis in a patient with giant cell tumor of the distal radius.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Orthop Trauma Surg. 2013 Mar 10.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00402-013-1692-y

AUTORES / AUTHORS:  - Damert HG; Altmann S; Kraus A

INSTITUCIÓN / INSTITUTION:  - Department of Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University,  Leipziger Strasse 44, 39120, Magdeburg, Germany.

RESUMEN / SUMMARY:  - INTRODUCTION: Treatment for giant cell tumors of the distal radius is challenging when motion is to be preserved. As standard wrist prostheses typically do not achieve favorable results, we treated a 36-year-old man with giant cell tumor of  the distal radius with a new, custom-made implant. METHODS: A custom-made wrist prosthesis with a long shaft was designed according to the patient’s X-ray findings. After complete tumor resection, the prosthesis was subsequently implanted into the distal radius without complications. RESULTS: Two months after surgery, range of motion was 30 degrees -0-25 degrees for extension/flexion, 10 degrees -0-5 degrees for ulnar/radial abduction, 80 degrees -0-0 for pronation/supination, complete range of motion for the fingers, and a grip strength of 6 kg. Two years after surgery, implant position was still correct and range of motion was 45 degrees -0-10 degrees for extension/flexion, 10 degrees -0-20 degrees for ulnar/radial abduction, and 80 degrees -0-10 degrees for pronation/supination. Grip strength was 16 kg, and DASH score was 25 compared to  39 before surgery. The patient returned to work as a craftsman. CONCLUSION: Custom-made wrist prostheses could become a practical option in patients with large defects of the distal radius who desire to preserve wrist motion.

 

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[82]

TÍTULO / TITLE:  - Localized and metastatic myxoid/round cell liposarcoma: Clinical and molecular observations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer. 2013 Feb 7. doi: 10.1002/cncr.27847.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cncr.27847

AUTORES / AUTHORS:  - Hoffman A; Ghadimi MP; Demicco EG; Creighton CJ; Torres K; Colombo C; Peng T; Lusby K; Ingram D; Hornick JL; Wang WL; Ravi V; Lazar AJ; Lev D; Pollock RE

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; The Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.

RESUMEN / SUMMARY:  - BACKGROUND.: Myxoid liposarcoma (MLPS), a disease especially of young adults with potential for local recurrence and metastasis, currently lacks solid prognostic factors and therapeutic targets. The authors of this report evaluated the natural history and outcome of patients with MLPS and commonly deregulated protein biomarkers. METHODS.: Medical records were retrospectively reviewed for patients  who presented to the authors’ institution with localized (n = 207) or metastatic  (n = 61) MLPS (1990 to 2010). A tissue microarray of MLPS patient specimens (n =  169) was constructed for immunohistochemical analysis of molecular markers. RESULTS.: The 5-year and 10-year disease-specific survival rates among patients with localized disease were 93% and 87%, respectively; male gender, age >45 years, and recurrent tumor predicted poor outcome. The local recurrence rate was  7.4%, and the risk of local recurrence was associated with recurrent tumors and nonextremity disease location. Male gender was the main risk factor for metastatic disease, which occurred in 13% of patients. Forty percent of patients  who had localized disease received chemotherapy, mostly in the neoadjuvant setting. Immunohistochemical analysis revealed significantly higher expression of C-X-C chemokine receptor type 4 (CXCR4) and platelet-derived growth factor beta (PDGFR-beta) in metastatic lesions versus localized lesions. Tumors with a round  cell phenotype expressed increased levels of CXCR4, p53, adipophilin, PDGFR-alpha, PDGFR-beta, and vascular endothelial growth factor relative to myxoid phenotype. Only the receptor tyrosine kinase encoded by the AXL gene (AXL) was identified as a prognosticator of disease-specific survival in univariate analysis. CONCLUSIONS.: In this study, the authors identified clinical and molecular outcome prognosticators for patients with MLPS as well as several potential therapeutic targets. Cancer 2013. Esta es una cita bibliográfica que va por delante de la publicación en papel. La fecha indicada en la cita provista, NO corresponde con la fecha o la cita bibliográfica de la publicación en papel. La cita bibliográfica definitiva (con el volumen y su paginación) saldrá en 1 ó 2 meses a partir de la fecha de la emisión electrónica-online. *** This is a bibliographic record ahead of the paper publication. The given date in the bibliographic record does not correspond to the date or the bibliographic citation on the paper publication. The publisher will provide the final bibliographic citation (with the volume, and pagination) within 1 or 2 months from the date the record was published online. © 2013 American Cancer Society.

 

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[83]

TÍTULO / TITLE:  - Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genes Chromosomes Cancer. 2013 Mar 18. doi: 10.1002/gcc.22055.

            ●● Enlace al texto completo (gratuito o de pago) 1002/gcc.22055

AUTORES / AUTHORS:  - Bianchini L; Birtwisle L; Saada E; Bazin A; Long E; Roussel JF; Michiels JF; Forest F; Dani C; Myklebost O; Birtwisle-Peyrottes I; Pedeutour F

INSTITUCIÓN / INSTITUTION:  - Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France; Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR 7284/INSERM  U1081, University of Nice-Sophia Antipolis, Nice, France. laurence.bianchini@unice.fr.

RESUMEN / SUMMARY:  - Most lipomas are characterized by translocations involving the HMGA2 gene in 12q14.3. These rearrangements lead to the fusion of HMGA2 with an ectopic sequence from the translocation chromosome partner. Only five fusion partners of  HMGA2 have been identified in lipomas so far. The identification of novel fusion  partners of HMGA2 is important not only for diagnosis in soft tissue tumors but also because these genes might have an oncogenic role in other tumors. We observed that t(1;12)(p32;q14) was the second most frequent translocation in our  series of lipomas after t(3;12)(q28;q14.3). We detected overexpression of HMGA2 mRNA and protein in all t(1;12)(p32;q14) lipomas. We used a fluorescence in situ  hybridization-based positional cloning strategy to characterize the 1p32 breakpoint. In 11 cases, we identified PPAP2B, a member of the lipid phosphate phosphatases family as the 1p32 target gene. Reverse transcription-polymerase chain reaction analysis followed by nucleotide sequencing of the fusion transcript indicated that HMGA2 3’ untranslated region (3’UTR) fused with exon 6  of PPAP2B in one case. In other t(1;12) cases, the breakpoint was extragenic, located in the 3’region flanking PPAP2B 3’UTR. Moreover, in one case showing a t(1;6)(p32;p21) we observed a rearrangement of PPAP2B and HMGA1, which suggests that HMGA1 might also be a fusion partner for PPAP2B. Our results also revealed that adipocytic differentiation of human mesenchymal stem cells derived from adipose tissue was associated with a significant decrease in PPAP2B mRNA expression suggesting that PPAP2B might play a role in adipogenesis. © 2013 Wiley Periodicals, Inc.

 

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[84]

TÍTULO / TITLE:  - Risk factors for seropositivity to Kaposi’s sarcoma associated herpesvirus (KSHV) among children in Uganda.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Acquir Immune Defic Syndr. 2013 Feb 11.

            ●● Enlace al texto completo (gratuito o de pago) 1097/QAI.0b013e31828a7056

AUTORES / AUTHORS:  - Wakeham K; Webb EL; Sebina I; Nalwoga A; Muhangi L; Miley W; Johnston WT; Ndibazza J; Whitby D; Newton R; Elliott AM

INSTITUCIÓN / INSTITUTION:  - 1Medical Research Council/Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda 2Department of Health Sciences, University of York, UK 3London School of Hygiene and Tropical Medicine, UK 4Viral Oncology Section, AIDS and Cancer Virus Program, SAIC-Frederick, Frederick National Laboratory for Cancer Research, USA 5International Agency for Research on Cancer, Lyon, France.

RESUMEN / SUMMARY:  - BACKGROUND:: Determinants of Kaposi’s sarcoma associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic, are not well understood. Local environmental factors, including other infectious agents, may be key. METHODS:: Within the context of a  well-characterised birth cohort we examined associations between various factors  and antibodies against KSHV, measured in stored plasma samples from 1823 mother-child pairs in Entebbe, Uganda. RESULTS:: Seroprevalence increased with increasing age of the child (p=0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs. 9%; odds ratio (OR) 1.4, 95%  confidence interval (CI) 1.1-2.0). It was also higher among children with HIV infection (29% vs. 10%; OR 3.1, 95% CI 1.2-8.3) or malaria parasitaemia (30% vs 10%; OR 4.1, 95% CI 2.4-7.0), than in children without. These associations were not explained by socioeconomic status. CONCLUSION:: The finding that KSHV serostatus is associated with malaria parasitaemia in children is novel. In a country endemic for KSHV, malaria may be a co-factor for KSHV infection or reactivation among children.

 

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[85]

TÍTULO / TITLE:  - Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) for palliative treatment of malignant ascites from gastrointestinal stromal tumours.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Palliat Care. 2012 Winter;28(4):293-6.

AUTORES / AUTHORS:  - Ong E; Diven C; Abrams A; Lee E; Mahadevan D

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, University of Arizona College of Medicine, 1501 N. Campbell Avenue, P.O. Box 245131, Tucson, Arizona 85724-5058, USA. eong@surgery.arizona.edu

 

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[86]

TÍTULO / TITLE:  - Endoglin (CD105) expression on microvessel endothelial cells in juvenile nasopharyngeal angiofibroma: Tissue microarray analysis and association with prognostic significance.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Head Neck. 2013 Mar 8. doi: 10.1002/hed.23210.

            ●● Enlace al texto completo (gratuito o de pago) 1002/hed.23210

AUTORES / AUTHORS:  - Wang JJ; Sun XC; Hu L; Liu ZF; Yu HP; Li H; Wang SY; Wang DH

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China.

RESUMEN / SUMMARY:  - BACKGROUND: The purpose of this study was to examine endoglin (CD105) expression  on microvessel endothelial cells (ECs) in juvenile nasopharyngeal angiofibroma (JNA) and its relationship with recurrence. METHODS: Immunohistochemistry was performed to detect CD105 expression in a tissue microarray from 70 patients with JNA. Correlation between CD105 expression on microvessel ECs and clinicopathological features, as well as tumor recurrence, were analyzed. RESULTS: Immunohistochemistry revealed CD105 expression on ECs but not in stroma  of patients with JNA. Chi-square analysis indicated CD105-based microvessel density (MVD) was correlated with JNA recurrence (p = .013). Univariate and multivariate analyses determined that MVD was a significant predictor of time to  recurrence (p = .009). The CD105-based MVD was better for predicting disease recurrence (AUROC: 0.673; p = .036) than other clinicopathological features. CONCLUSIONS: MVD is a useful predictor for poor prognosis of patients with JNA after curative resection. Angiogenesis, which may play an important role in the occurrence and development of JNA, is therefore a potential therapeutic target for JNA. © 2013 Wiley Periodicals, Inc. Head Neck, 2013.

 

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[87]

TÍTULO / TITLE:  - Changes in Health Status Among Aging Survivors of Pediatric Upper and Lower Extremity Sarcoma: A Report From the Childhood Cancer Survivor Study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Phys Med Rehabil. 2013 Feb 1. pii: S0003-9993(13)00097-X. doi: 10.1016/j.apmr.2013.01.013.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.apmr.2013.01.013

AUTORES / AUTHORS:  - Marina N; Hudson MM; Jones KE; Mulrooney DA; Avedian R; Donaldson SS; Popat R; West DW; Fisher P; Leisenring W; Stovall M; Robison LL; Ness KK

INSTITUCIÓN / INSTITUTION:  - Department of Pediatrics, Stanford University & Lucile Packard Children’s Hospital, Palo Alto, CA. Electronic address: nmarina@stanford.edu.

RESUMEN / SUMMARY:  - OBJECTIVE: To evaluate health status and participation restrictions in survivors  of childhood extremity sarcomas. DESIGN: Members of the Childhood Cancer Survivor Study cohort with extremity sarcomas who completed questionnaires in 1995, 2003,  or 2007 were included. SETTING: Cohort study of survivors of extremity sarcomas.  PARTICIPANTS: Childhood extremity sarcoma survivors (N=1094; median age at diagnosis, 13y (range, 0-20y); current age, 33y (range, 10-53y); 49% male; 87.5%  white; 75% had lower extremity tumors) who received their diagnosis and treatment between 1970 and 1986. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Prevalence rates for poor health status in 6 domains and 5 suboptimal social participation categories were compared by tumor location and treatment exposure with generalized estimating equations adjusted for demographic/personal factors and time/age. RESULTS: In adjusted models, when compared with upper extremity survivors, lower extremity survivors had an increased risk of activity limitations but a lower risk of not completing college. Compared with those who did not have surgery, those with limb-sparing (LS) and upper extremity amputations (UEAs) were 1.6 times more likely to report functional impairment, while those with an above-the-knee amputation (AKA) were 1.9 times more likely to report functional impairment. Survivors treated with LS were 1.5 times more likely to report activity limitations. Survivors undergoing LS were more likely to report inactivity, incomes <$20,000, unemployment, and no college degree. Those with UEAs more likely reported inactivity, unmarried status, and no college degree. Those with AKA more likely reported no college degree. Treatment with abdominal irradiation was associated with an increased risk of poor mental health, functional impairment, and activity limitation. CONCLUSIONS: Treatment of lower extremity sarcomas is associated with a 50% increased risk for activity limitations; upper extremity survivors are at a 10% higher risk for not completing college. The type of local control influences health status and participation restrictions. Both of these outcomes decline with age.

 

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[88]

TÍTULO / TITLE:  - Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genes Chromosomes Cancer. 2013 Mar 5. doi: 10.1002/gcc.22050.

            ●● Enlace al texto completo (gratuito o de pago) 1002/gcc.22050

AUTORES / AUTHORS:  - Mosquera JM; Sboner A; Zhang L; Kitabayashi N; Chen CL; Sung YS; Wexler LH; Laquaglia MP; Edelman M; Sreekantaiah C; Rubin MA; Antonescu CR

INSTITUCIÓN / INSTITUTION:  - Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, NY. jmm9018@med.cornell.edu.

RESUMEN / SUMMARY:  - Spindle cell rhabdomyosarcoma (RMS) is a rare form of RMS with different clinical characteristics between children and adult patients. Its genetic hallmark remains unknown and it remains debatable if there is pathogenetic relationship between the spindle cell and the so-called sclerosing RMS. We studied two pediatric and one adult spindle cell RMS by next generation RNA sequencing and FusionSeq data analysis to detect novel fusions. An SRF-NCOA2 fusion was detected in a spindle cell RMS from the posterior neck in a 7-month-old child. The fusion matched the tumor karyotype and was confirmed by FISH and RT-PCR, which showed fusion of SRF  exon 6 to NCOA2 exon 12. Additional 14 spindle cell (from 8 children and 6 adults) and 4 sclerosing (from 2 children and 2 adults) RMS were tested by FISH for the presence of abnormalities in NCOA2, SRF, as well as for PAX3 and NCOA1. NCOA2 rearrangements were found in two additional spindle cell RMS from a 3-month-old and a 4-week-old child. In the latter tumor, TEAD1 was identified by  rapid amplification of cDNA ends (RACE) to be the NCOA2 gene fusion partner. None of the adult tumors were positive for NCOA2 rearrangement. Despite similar histomorphology in adults and young children, these results suggest that spindle  cell RMS is a heterogeneous disease genetically as well as clinically. Our findings also support a relationship between NCOA2-rearranged spindle cell RMS occurring in young childhood and the so-called congenital RMS, which often displays rearrangements at 8q13 locus (NCOA2). © 2013 Wiley-Liss,Inc.

 

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[89]

TÍTULO / TITLE:  - A Prognostic Nomogram for Prediction of Recurrence in Desmoid Fibromatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Surg. 2013 Mar 25.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SLA.0b013e31828c8a30

AUTORES / AUTHORS:  - Crago AM; Denton B; Salas S; Dufresne A; Mezhir JJ; Hameed M; Gonen M; Singer S; Brennan MF

INSTITUCIÓN / INSTITUTION:  - Departments of *Surgery daggerBiostatistics and Epidemiology, Memorial Sloan-Kettering Cancer Center, New York, NY double daggerAix-Marseille Universite, INSERM U911 and Timone Hospital, Department of Medicine, Division of  Adult Oncology, Marseille, France section signLeon Berard Center, INSERM U590, 69373, Lyon, France paragraph signDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.

RESUMEN / SUMMARY:  - OBJECTIVE:: To construct a postoperative nomogram to estimate the risk of local recurrence for patients with desmoid tumors. BACKGROUND:: The standard management of desmoid tumors is resection, but many recur locally. Other options include observation or novel chemotherapeutics, but little guidance exists on selecting treatment. METHODS:: Patients undergoing resection during 1982-2011 for primary or locally recurrent desmoids were identified from a single-institution prospective database. Cox regression analysis was used to assess risk factors and to create a recurrence nomogram, which was validated using an international, multi-institutional data set. RESULTS:: Desmoids were treated surgically in 495 patients (median follow-up of 60 months). Of 439 patients undergoing complete gross resection, 100 (23%) had recurrence. Five-year local recurrence-free survival was 69%. Eight patients died of disease, all after R2 resection. Adjuvant radiation was not associated with improved local recurrence-free survival. In multivariate analysis, factors associated with recurrence were extremity location, young age, and large tumor size, but not margin. Abdominal wall tumors had the best outcome (5-year local recurrence-free survival rate of 91%). Age, site, and size were used to construct a nomogram with concordance index of 0.703 in internal validation and 0.659 in external validation. Integration of additional variables (R1 margin, sex, depth, and primary vs recurrent presentation) did not importantly improve concordance (internal concordance index of 0.707). CONCLUSIONS:: A postoperative nomogram including only size, site, and age predicts local recurrence and can aid in counseling patients. Systemic therapies may be appropriate for young patients with large, extremity desmoids, but surgery alone is curative for most abdominal wall lesions.

 

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[90]

TÍTULO / TITLE:  - Osteoblastoma of the ilium mimicking sacroiliitis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arthritis Rheum. 2013 Mar 4. doi: 10.1002/art.37915.

            ●● Enlace al texto completo (gratuito o de pago) 1002/art.37915

AUTORES / AUTHORS:  - Modaressi K; Phd BF; Bode P; Sutter R; Meili S; Weber U

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, University of Zurich, Orthopedic University Hospital  Balgrist, Zurich, Switzerland. kourosh.modaressi@balgrist.ch.

 

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[91]

TÍTULO / TITLE:  - Osteosarcoma of the mastoid process following radiation therapy of mucoepidermoid carcinoma of the parotid gland—a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Coll Antropol. 2012 Nov;36 Suppl 2:223-5.

AUTORES / AUTHORS:  - Brusic SK; Pusic M; Cvjetkovic N; Karnjus R; Candrlic B; Kukuljan M; Kastelan ZM; Miletic D

INSTITUCIÓN / INSTITUTION:  - University of Rijeka, Rijeka University Hospital Center, Department of Radiology, Rijeka, Croatia. skukicbr@hotmail.com

RESUMEN / SUMMARY:  - Radiation therapy is frequently used method in treatment of the head and neck malignancies. Osteosarcoma is a rare complication of radiation therapy and usually occurs after a long latent period. We report the case of 75-year-old female with osteosarcoma of the mastoid process. Twelve years before presentation she received radiation therapy after total parotidectomy and radical neck dissection in treatment of mucoepidermoid carcinoma of the parotid gland. Diagnostic procedures included contrast-enhanced CT and MRI of the head and neck  and HRCT of the temporal bone. The final diagnosis of the low grade osteosarcoma  was confirmed by biopsy. Diagnostic criteria were fulfilled and the lesion was classified as a radiation induced osteosarcoma.

 

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[92]

TÍTULO / TITLE:  - Magnetic resonance imaging-guided focused ultrasound surgery for symptomatic uterine fibroids: estimation of treatment efficacy using thermal dose calculations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Obstet Gynecol Reprod Biol. 2013 Mar 21. pii: S0301-2115(13)00112-7. doi: 10.1016/j.ejogrb.2013.02.023.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejogrb.2013.02.023

AUTORES / AUTHORS:  - Yoon SW; Cha SH; Ji YG; Kim HC; Lee MH; Cho JH

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic Radiology, CHA Bundang Medical Center, CHA University, Republic of Korea. Electronic address: jansons@cha.ac.kr.

RESUMEN / SUMMARY:  - OBJECTIVE: To study the correlation between the predicted thermal dose volume (TDV) and the actual ablation volumes in MR-guided focused ultrasound surgery (MRgFUS) for symptomatic uterine fibroids, and to follow up the outcome for 12 months post-treatment. STUDY DESIGN: Phase-difference fast spoiled gradient-echo  MR images were used to analyze thermal change during the energy deliveries of MRgFUS in 60 consecutive patients treated for symptomatic uterine fibroids. The TDV obtained through analysis of these MR images was compared with the non-perfused volume (NPV) measured on post-treatment contrast enhanced T1-weighted images. Final values of TDV ratio and NPV ratio were obtained by dividing these values by original fibroid volume. Patients were followed for 12 months post-treatment to assess symptomatic relief using the symptom severity score (SSS). RESULTS: Treatments in which we managed to reach a TDV ratio larger  than 27% of the treated fibroid yielded a ratio of NPV to TDV of 1.1+/-0.5, indicating accurate control of the non-invasive procedure. Patient symptoms, as measured by the SSS, continuously decreased from a mean baseline score of 50+/-22 to 19+/-12 (P<0.0001) 12 months post-treatment. CONCLUSIONS: At large treatment volumes (exceeding 27% TDV ratio), thermal dose estimates correspond very closely to non-perfused volumes measured immediately post treatment. These large treatment volumes result in continuous clinical improvement throughout the first  12 months after MRgFUS.

 

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[93]

TÍTULO / TITLE:  - A whole-genome RNA interference screen for human cell factors affecting myxoma virus replication.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Apr;87(8):4623-41. doi: 10.1128/JVI.02617-12. Epub 2013 Feb 13.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.02617-12

AUTORES / AUTHORS:  - Teferi WM; Dodd K; Maranchuk R; Favis N; Evans DH

INSTITUCIÓN / INSTITUTION:  - Department of Medical Microbiology & Immunology, Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada.

RESUMEN / SUMMARY:  - Myxoma virus (MYXV) provides an important model for investigating host-pathogen interactions. Recent studies have also highlighted how mutations in transformed human cells can expand the host range of this rabbit virus. Although virus growth depends upon interactions between virus and host proteins, the nature of these interactions is poorly understood. To address this matter, we performed small interfering RNA (siRNA) screens for genes affecting MYXV growth in human MDA-MB-231 cells. By using siRNAs targeting the whole human genome (21,585 genes), a subset of human phosphatases and kinases (986 genes), and also a custom siRNA library targeting selected statistically significant genes (“hits”) and nonsignificant genes (“nonhits”) of the whole human genome screens (88 genes), we identified 711 siRNA pools that promoted MYXV growth and 333 that were inhibitory. Another 32 siRNA pools (mostly targeting the proteasome) were toxic.  The overall overlap in the results was about 25% for the hits and 75% for the nonhits. These pro- and antiviral genes can be clustered into pathways and related groups, including well-established inflammatory and mitogen-activated protein kinase pathways, as well as clusters relating to beta-catenin and the Wnt signaling cascade, the cell cycle, and cellular metabolism. The validity of a subset of these hits was independently confirmed. For example, treating cells with siRNAs that might stabilize cells in G1, or inhibit passage into S phase, stimulated MYXV growth, and these effects were reproduced by trapping cells at the G1/S boundary with an inhibitor of cyclin-dependent kinases 4/6. By using 2-deoxy-d-glucose and plasmids carrying the gene for phosphofructokinase, we also confirmed that infection is favored by aerobic glycolytic metabolism. These studies provide insights into how the growth state and structure of cells affect  MYXV growth and how these factors might be manipulated to advantage in oncolytic  virus therapy.

 

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[94]

TÍTULO / TITLE:  - Long-term efficacy of imatinib for treatment of metastatic GIST.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Chemother Pharmacol. 2013 Mar 17.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00280-013-2135-8

AUTORES / AUTHORS:  - Patel S

INSTITUCIÓN / INSTITUTION:  - Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA, spatel@mdanderson.org.

RESUMEN / SUMMARY:  - PURPOSE: Imatinib is an effective and approved treatment for advanced gastrointestinal stromal tumor (GIST). Continuous imatinib treatment is recommended by current guidelines. This review summarizes the long-term efficacy  and safety of imatinib for patients with metastatic GIST. METHODS: Key clinical studies were reviewed-including B2222, S0033, and BFR14-with particular emphasis  on recently reported results of the long-term clinical outcome of imatinib for metastatic GIST. RESULTS: The B2222 and S0033 studies recently reported 10-year follow-up results that demonstrate the long-term efficacy of imatinib. Furthermore, results from the BFR14 study demonstrate that imatinib treatment should not be interrupted and that the efficacy of imatinib following reintroduction is inferior compared with the continuous administration group. The S0033 study also supports the importance of dose optimization and dose escalation of imatinib in patients with KIT exon 9 mutations or progressive disease. These studies demonstrate that individual patient characteristics should be evaluated for optimal patient management. Managing adverse events proactively is very important to maintain compliance. CONCLUSIONS: The results from these studies demonstrate that long-term imatinib extends survival in patients with advanced GIST. Furthermore, these studies support the safety of long-term imatinib therapy in this patient population.

 

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[95]

TÍTULO / TITLE:  - Modulation of stretch-induced myocyte remodelling and gene expression by nitric oxide: A novel role for lipoma preferred partner in myofibrillogenesis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Physiol Heart Circ Physiol. 2013 Mar 15.

            ●● Enlace al texto completo (gratuito o de pago) 1152/ajpheart.00004.2013

AUTORES / AUTHORS:  - Hooper CL; Paudyal A; Dash PR; Boateng SY

INSTITUCIÓN / INSTITUTION:  - 1University of Reading.

RESUMEN / SUMMARY:  - Prolonged hemodynamic load eventually leads to maladaptive cardiac adaptation and heart failure. Signalling pathways that underlie these changes are still poorly understood. The adaptive response to mechanical load is mediated by mechanosensors which convert the mechanical stimuli into a biological response. We examined the effect of cyclic mechanical stretch on myocyte adaptation using neonatal rat ventricular myocytes with 10% (adaptive) or 20% (maladaptive) maximum strain, 1Hz for 48hours to mimic in vivo mechanical stress. Cells were also treated with and without L-NAME, a general nitric oxide synthase (NOS) inhibitor to suppress NO production. Maladaptive 20% mechanical stretch led to a  significant loss of intact sarcomeres which was rescued by L-NAME (P<0.05, n>/=5  cultures). We hypothesized that the mechanism was through NO-induced alteration of myocyte gene expression. L-NAME up-regulated the mechanosensing proteins Muscle LIM protein (MLP (by 100%, p<0.05, n=3 cultures)) and lipoma preferred partner, a novel cardiac protein (LPP (by 80%, p<0.05, n=3 cultures)). L-NAME also significantly altered the subcellular localisation of LPP and MLP in a manner that favoured growth and adaptation. These findings suggest that NO participates in stretch-mediated adaptation. The use of isoform selective NOS inhibitors indicated a complex interaction between iNOS and nNOS isoforms regulate gene expression. LPP knockdown by siRNA led to formation of alpha-actinin aggregates and z-bodies showing that myofibrillogenesis was impaired. There was an up-regulation of MUL1 ubiquitin ligase by 75% (P<0.05, n=5 cultures). These data indicate that NO contributes to stretch-mediated adaptation via the up-regulation of proteins associated mechansensing and myofibrillogenesis.

 

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[96]

TÍTULO / TITLE:  - Kaposi’s-sarcoma-associated-herpesvirus-activated dendritic cells promote HIV-1 trans-infection and suppress CD4 T cell proliferation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Virology. 2013 Mar 16. pii: S0042-6822(13)00123-2. doi: 10.1016/j.virol.2013.02.018.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.virol.2013.02.018

AUTORES / AUTHORS:  - Liu W; Qin Y; Bai L; Lan K; Wang JH

INSTITUCIÓN / INSTITUTION:  - Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, the Chinese Academy of Sciences, Shanghai, China; Graduate School of the Chinese  Academy of Sciences, Beijing, China.

RESUMEN / SUMMARY:  - Infection of Kaposi’s sarcoma-associated herpesvirus (KSHV) is commonly occurred  in AIDS patients. KSHV and HIV-1 act cooperatively in regulating infection with each other and in human carcinogenesis. Dendritic cells (DCs), as the pivotal cells in host immunity, may be modulated by both viruses, for immunoevasion and dissemination, therefore, the interaction between DCs and each virus has been a prior focus for pathogenesis elucidation. Here, we assessed the potential effect  of KSHV on DC-HIV-1 interaction. We found that KSHV stimulation could promote maturation of monocyte-derived DCs (MDDCs) and impaired the ability of MDDCs to drive proliferation of resting CD4+ T cells, demonstrating the immunosuppression  induced by KSHV. More importantly, KSHV-stimulated MDDCs could capture more HIV-1 and efficiently transferred these infectious viruses to Hut/CCR5 T cell line. Our results reveal the novel modulation of DC-mediated HIV-1 dissemination by KSHV, and highlight the importance of studying DC-HIV-1 interaction to elucidate HIV/AIDS pathogenesis.

 

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[97]

TÍTULO / TITLE:  - Vitamin d and the risk of uterine fibroids.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Epidemiology. 2013 May;24(3):447-53. doi: 10.1097/EDE.0b013e31828acca0.

            ●● Enlace al texto completo (gratuito o de pago) 1097/EDE.0b013e31828acca0

AUTORES / AUTHORS:  - Baird DD; Hill MC; Schectman JM; Hollis BW

INSTITUCIÓN / INSTITUTION:  - From the aEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC; bDepartment of Radiology, George Washington University Medical Center, George Washington University, Washington, DC; cDepartment of Health Care Sciences, George Washington University Medical Center, George Washington University, Washington, DC; and dDepartment of Pediatrics, The  Medical University of South Carolina, Charleston, SC.

RESUMEN / SUMMARY:  - BACKGROUND: : Uterine leiomyomata (also known as fibroids) are benign tumors of uterine smooth muscle that are characterized by overproduction of extracellular matrix. Fibroids are the leading indication for hysterectomy in the United States. The active metabolite of vitamin D has been shown to inhibit cell proliferation and extracellular matrix production in fibroid tissue culture and to reduce fibroid volume in the Eker rat. No previous study has examined whether  vitamin D is related to fibroid status in women. METHODS: : The National Institute of Environmental Health Sciences Uterine Fibroid Study enrolled randomly selected 35- to 49-year-old women who were members of an urban health plan during 1996-1999. Fibroid status was determined by ultrasound screening of premenopausal women (620 blacks, 416 whites). Vitamin D status was assessed in stored plasma by radioimmunoassay of 25-hydroxyvitamin D (25(OH)D) and questionnaire data on sun exposure. Associations were evaluated with logistic regression, controlling for potential confounders. RESULTS: : Only 10% of blacks  and 50% of whites had levels of 25(OH)D regarded as sufficient (>20 ng/ml). Women with sufficient vitamin D had an estimated 32% lower odds of fibroids compared with those with vitamin D insufficiency (adjusted odds ratio [aOR] = 0.68, 95% confidence interval [CI] = 0.48-0.96). The association was similar for blacks and whites. Self-reported sun exposure >/=1 hour per day (weather permitting) was also associated with reduced odds of fibroids (aOR = 06. [0.4-0.9]), with no evidence of heterogeneity by ethnicity. CONCLUSIONS: : The consistency of findings for questionnaire and biomarker data, the similar patterns seen in blacks and whites, and the biological plausibility provide evidence that sufficient vitamin D is associated with a reduced risk of uterine fibroids.

 

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[98]

TÍTULO / TITLE:  - Interactions of the Kaposi’s Sarcoma-Associated Herpesvirus Nuclear Egress Complex: ORF69 Is a Potent Factor for Remodeling Cellular Membranes.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Apr;87(7):3915-29. doi: 10.1128/JVI.03418-12. Epub 2013 Jan 30.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.03418-12

AUTORES / AUTHORS:  - Luitweiler EM; Henson BW; Pryce EN; Patel V; Coombs G; McCaffery JM; Desai PJ

INSTITUCIÓN / INSTITUTION:  - Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

RESUMEN / SUMMARY:  - All herpesviruses encode a complex of two proteins, referred to as the nuclear egress complex (NEC), which together facilitate the exit of assembled capsids from the nucleus. Previously, we showed that the Kaposi’s sarcoma-associated herpesvirus (KSHV) NEC specified by the ORF67 and ORF69 genes when expressed in insect cells using baculoviruses for protein expression forms a complex at the nuclear membrane and remodels these membranes to generate nuclear membrane-derived vesicles. In this study, we have analyzed the functional domains of the KSHV NEC proteins and their interactions. Site-directed mutagenesis of gammaherpesvirus conserved residues revealed functional domains of these two proteins, which in many cases abolish the formation of the NEC and remodeling of  nuclear membranes. Small in-frame deletions within ORF67 in all cases result in loss of the ability of the mutant protein to induce cellular membrane proliferation as well as to interact with ORF69. Truncation of the C terminus of  ORF67 that resides in the perinuclear space does not impair the functions of ORF67; however, deletion of the transmembrane domain of ORF67 produces a protein  that cannot induce membrane proliferation but can still interact with ORF69 in the nucleus and can be tethered to the nuclear membrane by virtue of its interaction with the wild-type-membrane-anchored ORF67. In-frame deletions in ORF69 have varied effects on NEC formation, but all abolish remodeling of nuclear membranes into circular structures. One mutant interacts with ORF67 as well as the wild-type protein but cannot function in membrane curvature and fission events that generate circular vesicles. These studies genetically confirm that ORF67 is required for cellular membrane proliferation and that ORF69 is the factor required to remodel these duplicated membranes into circular-virion-size vesicles. Furthermore, we also investigated the NEC encoded by Epstein-Barr virus (EBV). The EBV complex comprised of BFRF1 and BFLF2 was visualized at the nuclear membrane using autofluorescent protein fusions. BFRF1 is a potent inducer of membrane proliferation; however, BFLF2 cannot remodel these membranes into circular structures. What was evident is the superior remodeling activity of ORF69, which could convert the host membrane proliferations induced by BFRF1 into circular structures.

 

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[99]

TÍTULO / TITLE:  - Rapidly Growing Cardiac Papillary Fibroelastoma in a Teenager with Sickle Cell Disease.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Echocardiography. 2013 Mar 12. doi: 10.1111/echo.12158.

            ●● Enlace al texto completo (gratuito o de pago) 1111/echo.12158

AUTORES / AUTHORS:  - Sernich S; Craver R; Pettitt TW; Caspi J; Ascuitto R

INSTITUCIÓN / INSTITUTION:  - Department of Pediatrics, LSU School of Medicine, New Orleans, Louisiana; Children’s Hospital of New Orleans, New Orleans, Louisiana.

 

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[100]

TÍTULO / TITLE:  - Exonic Mutations of TSC2/TSC1 Are Common but Not Seen in All Sporadic Pulmonary Lymphangioleiomyomatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Respir Crit Care Med. 2013 Mar 15;187(6):663-5.

            ●● Enlace al texto completo (gratuito o de pago) 1164/ajrccm.187.6.663

AUTORES / AUTHORS:  - Badri KR; Gao L; Hyjek E; Schuger N; Schuger L; Qin W; Chekaluk Y; Kwiatkowski DJ; Zhe X

 

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[101]

TÍTULO / TITLE:  - Chromatin Immunoprecipitation and Microarray Analysis Suggest Functional Cooperation between Kaposi’s Sarcoma-Associated Herpesvirus ORF57 and K-bZIP.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Apr;87(7):4005-16. doi: 10.1128/JVI.03459-12. Epub 2013 Jan 30.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.03459-12

AUTORES / AUTHORS:  - Hunter OV; Sei E; Richardson RB; Conrad NK

INSTITUCIÓN / INSTITUTION:  - UT Southwestern Medical Center, Department of Microbiology, Dallas, Texas, USA.

RESUMEN / SUMMARY:  - The Kaposi’s sarcoma-associated herpesvirus (KSHV) open reading frame 57 (ORF57)-encoded protein (Mta) is a multifunctional regulator of viral gene expression. ORF57 is essential for viral replication, so elucidation of its molecular mechanisms is important for understanding KSHV infection. ORF57 has been implicated in nearly every aspect of viral gene expression, including transcription, RNA stability, splicing, export, and translation. Here we demonstrate that ORF57 interacts with the KSHV K-bZIP protein in vitro and in cell extracts from lytically reactivated infected cells. To further test the biological relevance of the interaction, we performed a chromatin immunoprecipitation and microarray (ChIP-chip) analysis using anti-ORF57 antibodies and a KSHV tiling array. The results revealed four specific areas of enrichment, including the ORF4 and K8 (K-bZIP) promoters, as well as oriLyt, all  of which interact with K-bZIP. In addition, ORF57 associated with DNA corresponding to the PAN RNA transcribed region, a known posttranscriptional target of ORF57. All of the peaks were RNase insensitive, demonstrating that ORF57 association with the viral genome is unlikely to be mediated exclusively by an RNA tether. Our data demonstrate that ORF57 associates with the viral genome by using at least two modes of recruitment, and they suggest that ORF57 and K-bZIP coregulate viral gene expression during lytic infection.

 

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[102]

TÍTULO / TITLE:  - Myxoma and vaccinia viruses bind differentially to human leukocytes.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Apr;87(8):4445-60. doi: 10.1128/JVI.03488-12. Epub 2013 Feb 6.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.03488-12

AUTORES / AUTHORS:  - Chan WM; Bartee EC; Moreb JS; Dower K; Connor JH; McFadden G

INSTITUCIÓN / INSTITUTION:  - Department of Molecular Genetics and Microbiology.

RESUMEN / SUMMARY:  - Myxoma virus (MYXV) and vaccinia virus (VACV), two distinct members of the family Poxviridae, are both currently being developed as oncolytic virotherapeutic agents. Recent studies have demonstrated that ex vivo treatment with MYXV can selectively recognize and kill contaminating cancerous cells from autologous bone marrow transplants without perturbing the engraftment of normal CD34(+) hematopoietic stem and progenitor cells. However, the mechanism(s) by which MYXV  specifically recognizes and eliminates the cancer cells in the autografts is not  understood. While little is known about the cellular attachment factor(s) exploited by MYXV for entry into any target cells, VACV has been shown to utilize cell surface glycosaminoglycans such as heparan sulfate (HS), the extracellular matrix protein laminin, and/or integrin beta1. We have constructed MYXV and VACV  virions tagged with the Venus fluorescent protein and compared their characteristics of binding to various human cancer cell lines as well as to primary human leukocytes. We report that the binding of MYXV or VACV to some adherent cell lines could be partially inhibited by heparin, but laminin blocked  only VACV binding. In contrast to cultured fibroblasts, the binding of MYXV and VACV to a wide spectrum of primary human leukocytes could not be competed by either HS or laminin. Additionally, MYXV and VACV exhibited very different binding characteristics against certain select human leukocytes, suggesting that  the two poxviruses utilize different cell surface determinants for the attachment to these cells. These results indicate that VACV and MYXV can exhibit very different oncolytic tropisms against some cancerous human leukocytes.

 

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[103]

TÍTULO / TITLE:  - Long telomeres in peripheral blood leukocytes are associated with an increased risk of soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer. 2013 Feb 13. doi: 10.1002/cncr.27984.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cncr.27984

AUTORES / AUTHORS:  - Xie H; Wu X; Wang S; Chang D; Pollock RE; Lev D; Gu J

INSTITUCIÓN / INSTITUTION:  - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas; State Key Laboratory of Reproductive Medicine, Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital Affiliated With  Nanjing Medical University, Nanjing, China.

RESUMEN / SUMMARY:  - BACKGROUND: Human telomeres consisting of long, tandem repeats of the nucleotide  sequence TTAGGG at the chromosome ends are essential for maintaining chromosomal  stability. Previous epidemiologic studies have indicated that shorter telomere length in peripheral blood leukocytes (PBLs) is associated with the development of many cancers. However, the relation between PBL telomere length and the risk of soft tissue sarcoma (STS) has not been investigated. METHODS: The relative telomere length (RTL) was determined in PBLs using real-time polymerase chain reaction in this case-control study. The study participants included 137 patients with histologically confirmed STS (cases) who had received no prior chemotherapy  or radiotherapy and 137 healthy controls who were frequency-matched to cases on age, sex, and ethnicity. RESULTS: Patients in the case group had significantly longer RTL than controls (1.46 +/- 0.42 for cases vs 1.15 +/- 0.39 for controls;  P < .001). By using median RTL in the controls as a cutoff level, individuals who had long telomere length were associated with a significantly increased risk of STS compared with those who had short telomere length (adjusted odds ratio, 4.71; 95% confidence interval, 2.63-8.44). When participants were categorized further into 3 or 4 groups according to the tertile or quartile RTL values of healthy controls, a significant dose-response relation was observed between longer RTL and increased risks of STS. CONCLUSIONS: The current results provided the first epidemiologic evidence that longer telomere length in PBLs is associated significantly with an increased risk of STS, potentially suggesting an important  role for telomere maintenance in STS development. Cancer 2013. Esta es una cita bibliográfica que va por delante de la publicación en papel. La fecha indicada en la cita provista, NO corresponde con la fecha o la cita bibliográfica de la publicación en papel. La cita bibliográfica definitiva (con el volumen y su paginación) saldrá en 1 ó 2 meses a partir de la fecha de la emisión electrónica-online. *** This is a bibliographic record ahead of the paper publication. The given date in the bibliographic record does not correspond to the date or the bibliographic citation on the paper publication. The publisher will provide the final bibliographic citation (with the volume, and pagination) within 1 or 2 months from the date the record was published online. © 2013 American Cancer Society.

 

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[104]

TÍTULO / TITLE:  - Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Control Release. 2013 Mar 21. pii: S0168-3659(13)00155-7. doi: 10.1016/j.jconrel.2013.03.012.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jconrel.2013.03.012

AUTORES / AUTHORS:  - Duchi S; Sotgiu G; Lucarelli E; Ballestri M; Dozza B; Santi S; Guerrini A; Dambruoso P; Giannini S; Donati D; Varchi G

INSTITUCIÓN / INSTITUTION:  - Osteoarticolar Regeneration Laboratory, Rizzoli Orthopaedic Institute (IOR), Via  di Barbiano 1/10, 40136, Bologna, Italy.

RESUMEN / SUMMARY:  - Mesenchymal stem cells (MSC) have the unique ability to home and engraft in tumor stroma. These features render them potentially a very useful tool as targeted delivery vehicles which can deliver therapeutic drugs to the tumor stroma. In the present study, we investigate whether fluorescent core-shell PMMA nanoparticles (FNPs) post-loaded with a photosensitizer, namely meso-tetrakis (4-sulfonatophenyl) porphyrin (TPPS) and uploaded by MSC could trigger osteosarcoma (OS) cell death in vitro upon specific photoactivation. In co-culture studies we demonstrate using laser confocal microscopy and time lapse  imaging, that only after laser irradiation MSC loaded with photosensitizer-coated fluorescent NPs (TPPS@FNPs) undergo cell death and release reactive oxygen species (ROS) which are sufficient to trigger cell death of all OS cells in the culture. These results encourage further studies aimed at proving the efficacy of this novel tri-component system for PDT applications.

 

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[105]

TÍTULO / TITLE:  - Letter to the Editor: Chordoma stem cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurosurg. 2013 Apr;118(4):913-4. doi: 10.3171/2012.3.JNS12478. Epub 2013 Feb 8.

            ●● Enlace al texto completo (gratuito o de pago) 3171/2012.3.JNS12478

AUTORES / AUTHORS:  - Lee CH; Chang WC; Yeh CC; Jiang PJ; Sytwu HK; Hueng DY

INSTITUCIÓN / INSTITUTION:  - Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

 

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[106]

TÍTULO / TITLE:  - Role of Dynamic MRI and Clinical Assessment in Predicting Histologic Response to  Neoadjuvant Chemotherapy in Bone Sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Clin Oncol. 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1097/COC.0b013e31827b4f6f

AUTORES / AUTHORS:  - Amit P; Patro DK; Basu D; Elangovan S; Parathasarathy V

INSTITUCIÓN / INSTITUTION:  - *Department of Orthopaedics, Acharyashree Bhikshu Government Hospital, New Delhi  Departments of daggerOrthopaedics double daggerPathology section signRadiodiagnosis parallelRadiotherapy, JIPMER, Pondicherry, India.

RESUMEN / SUMMARY:  - BACKGROUND:: Neoadjuvant chemotherapy has become the first-line therapy in management of malignant bone tumors. Response to it is best assessed with evaluation of tumor necrosis postoperatively. This study was carried out to evaluate the role of clinical parameters and dynamic magnetic resonance imaging (MRI) to predict the histologic response before surgery. MATERIALS AND METHODS::  Our study included 14 patients (12 osteosarcoma and 2 malignant fibrous histiocytoma) with mean age of 21.8 years, treated with neoadjuvant chemotherapy  followed by surgery, who were evaluated clinically and with dynamic MRI twice, before starting chemotherapy and before surgery. Clinical parameters (pain, tumor girth, maximum tumor diameter, surface temperature, and consistency) and dynamic  MRI parameter (slope of signal intensity-time curve) were correlated with histologic response (percentage of necrosis) using Pearson and Spearman correlation test. RESULTS:: Significant correlation with histologic necrosis was  seen in change in pain, tumor girth, maximum tumor diameter, surface temperature, and dynamic MRI slope (P<0.01). Change in consistency did not show significant correlation (P>0.05). Complete relieve of pain with reduction of >4 grades, >/=5% reduction in tumor girth, >/=8% reduction in tumor diameter, attainment of normal body temperature or decrease of >/=2 degrees F temperature, and >/=60% reduction  in slope proved to be an indicator of good histologic response. CONCLUSIONS:: Both dynamic MRI and clinical evaluation are reliable methods of assessment of response of the bone tumors to neoadjuvant chemotherapy.

 

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[107]

TÍTULO / TITLE:  - Degraded iota-carrageenan can induce apoptosis in human osteosarcoma cells via the Wnt/beta-catenin signaling pathway.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nutr Cancer. 2013;65(1):126-31. doi: 10.1080/01635581.2013.741753.

            ●● Enlace al texto completo (gratuito o de pago) 1080/01635581.2013.741753

AUTORES / AUTHORS:  - Jin Z; Han YX; Han XR

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, First Affiliated Hospital of China Medical University, Shenyang, China. jinzheFH@163.com

RESUMEN / SUMMARY:  - Osteosarcoma (OS) is a high-grade malignant bone tumor. Therefore, using both in  vitro and in vivo assays, the effects of degraded iota-Carrageenan (iota-CGN) on  a human osteosarcoma cell line, HOS, were examined. Degraded iota-CGN was observed to induce apoptosis and G(1) phase arrest in HOS cells. Moreover, degraded iota-CGN suppressed tumor growth in established xenograft tumor models.  Accordingly, the survival rate of these mice was significantly higher than that of mice bearing tumors treated with native iota-CGN or PBS. In addition, the formation of intratumoral microvessels was inhibited following treatment with degraded iota-CGN. In Western blot assays, degraded iota-CGN was found to inhibit the Wnt/beta-catenin signaling pathway. Overall, these studies demonstrate the antitumor activity of degraded iota-CGN toward the OS cell line, HOS. Moreover, valuable insight into the mechanisms mediated by degraded iota-CGN was obtained,  potentially leading to the identification of novel treatments for OS. However, additional studies are needed to confirm these results in other cell types, particularly in human umbilical vein endothelial cells.

 

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[108]

TÍTULO / TITLE:  - Midterm Results after Uterine Artery Embolization Versus MR-Guided High-Intensity Focused Ultrasound Treatment for Symptomatic Uterine Fibroids.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cardiovasc Intervent Radiol. 2013 Mar 1.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00270-013-0582-6

AUTORES / AUTHORS:  - Froeling V; Meckelburg K; Scheurig-Muenkler C; Schreiter NF; Kamp J; Maurer MH; Beck A; Hamm B; Kroencke TJ

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Charite-Universitatsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353, Berlin, Germany, vera.froeling@charite.de.

RESUMEN / SUMMARY:  - PURPOSE: To compare the rate of reintervention and midterm changes in symptom severity (SS) and Total health-related quality of life (HRQoL) scores after uterine artery embolization (UAE) and magnetic resonance-guided high-intensity focused ultrasound (MR-g HIFU) for symptomatic uterine fibroids. METHODS: Eighty  women (median age 38.3 years), equally eligible for MR-g HIFU and UAE who underwent one of both treatments between 2002 and 2009 at our institution, were included. The primary end point of the study was defined as the rate of reintervention after both therapies. The secondary outcome was defined as changes in SS and Total HRQoL scores after treatment. SS and Total HRQoL scores before treatment and at midterm follow-up (median 13.3 months) were assessed by the uterine fibroid symptom and quality-of-life questionnaire (UFS-QoL) and compared. RESULTS: The rate of reintervention was significantly lower after UAE than after  MR-g HIFU (p = 0.002). After both treatments, SS and Total HRQoL scores improved  significantly from baseline to follow-up (UAE: p < 0.001, p < 0.001; MR-g HIFU: p = 0.002, p < 0.001). Total HRQoL scores were significantly higher after UAE than  after MR-g HIFU (p = 0.032). Changes in the SS scores did not differ significantly for both treatments (p = 0.061). CONCLUSION: UAE and MR-g HIFU significantly improved the health-related quality of life of women with symptomatic uterine fibroids. After UAE, the change in Total HRQoL score improvement was significantly better, and a significantly lower rate of reintervention was observed.

 

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[109]

TÍTULO / TITLE:  - A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cancer. 2013 Mar 11. pii: S0959-8049(13)00150-0. doi: 10.1016/j.ejca.2013.02.020.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejca.2013.02.020

AUTORES / AUTHORS:  - Georges S; Chesneau J; Hervouet S; Taurelle J; Gouin F; Redini F; Padrines M; Heymann D; Fortun Y; Verrecchia F

INSTITUCIÓN / INSTITUTION:  - LUNAM Universite, France; INSERM, UMR-S 957, Nantes, France; Universite de Nantes, Laboratoire de Physiopathologie de la Resorption Osseuse et Therapie des  Tumeurs Osseuses Primitives, Nantes, France; CHU de Nantes, Nantes, France; Equipe labellisee Ligue contre le Cancer 2012, Nantes, France.

RESUMEN / SUMMARY:  - BACKGROUND: Osteosarcoma is the most common primary malignant bone tumour in children and adolescents for whom the prognosis remains unfavourable despite treatment protocols that combine chemotherapy and surgery. Metalloproteinases decisively contribute to cancer development and promotion by regulating cell growth, angiogenesis or inflammation. However, their role in osteosarcoma remains still unknown. METHODS: A screening of a large panel of metalloproteinases and their inhibitors, carried out in osteolytic (K7M2 and POS-1) or osteoblastic (MOS-J) mouse osteosarcoma models, shows that a member of a family of cell surface metallopeptidases, A Disintegrin And Metalloproteinase 12 (ADAM12), is highly expressed in the K7M2 and POS-1 cell lines and weakly expressed in the MOS-J cell line. To investigate whether ADAM12, involved in several pathologic conditions characterised by abnormal cell growth, plays a role in osteosarcoma tumour growth, ADAM12 was overexpressed in MOS-J and downregulated in K7M2 cells. RESULTS: In vivo experiments demonstrated that ADAM12 favours tumour growth, leading to a significant modification in animal survival. In vitro assays showed  that ADAM12 knockdown in K7M2 cells slows cell proliferation. In addition, the study of microarchitectural parameters, assessed by micro-computed tomography (CT) analysis, showed that ADAM12 favours bone osteolysis, as demonstrated both in an ADAM12 overexpressing (MOS-J) and a knockdown (K7M2) model. Histological analysis showed that ADAM12 inhibited osteoblast activity and therefore enhanced  bone resorption. CONCLUSIONS: Our study demonstrates that ADAM12 expression not only favours tumour growth but also associates enhanced osteolysis with a significant reduction in animal survival, suggesting that ADAM12 could be a new therapeutic target in osteosarcoma.

 

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[110]

TÍTULO / TITLE:  - Synergistic cytotoxic effects of inorganic phosphate and chemotherapeutic drugs on human osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Rep. 2013 Feb 26. doi: 10.3892/or.2013.2306.

            ●● Enlace al texto completo (gratuito o de pago) 3892/or.2013.2306

AUTORES / AUTHORS:  - Spina A; Sorvillo L; Chiosi E; Esposito A; Di Maiolo F; Sapio L; Caraglia M; Naviglio S

INSTITUCIÓN / INSTITUTION:  - Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Medical School, I80138 Naples, Italy.

RESUMEN / SUMMARY:  - Novel therapeutic approaches are required for the treatment of osteosarcoma. Combination chemotherapy is receiving increased attention in order to identify compounds that may increase the therapeutic index of clinical anticancer drugs. In this regard, naturally occurring molecules with antitumor activity and with limited toxicity to normal tissues have been suggested as possible candidates for investigation of their synergistic efficacy in combination with antineoplastic drugs. Inorganic phosphate (Pi) is an essential nutrient for living organisms. Relevantly, Pi has emerged as an important signaling molecule capable of modulating multiple cellular functions by altering signal transduction pathways,  gene expression and protein abundance in many cell types. Previously, we showed that Pi inhibits proliferation and aggressiveness of U2OS human osteosarcoma cells and that Pi is capable of inducing sensitization of osteosarcoma cells to doxorubicin in a p53-dependent manner. In this study, we extended the role of Pi  in the chemosensitivity of osteosarcoma cells to other anticancer drugs. Specifically, we report and compare the antiproliferative effects of a combination between Pi and doxorubicin, Taxol® and 5-fluorouracil (5-FU) treatments. We found that Pi increases the antiproliferative response to both Taxol and doxorubicin to a similar extent. On the other hand, Pi did not potentiate the anticancer effects induced by 5-FU. These effects were paralleled  by apoptosis induction and were cell cycle-dependent. The clinical significance of our data and their potential therapeutic applications for improving osteosarcoma treatment are discussed.

 

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[111]

TÍTULO / TITLE:  - Opposite cytokine synthesis by fibroblasts in contact co-culture with osteosarcoma cells compared with transwell co-cultures.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cytokine. 2013 Apr;62(1):48-51. doi: 10.1016/j.cyto.2013.02.028. Epub 2013 Mar 19.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.cyto.2013.02.028

AUTORES / AUTHORS:  - David MS; Kelly E; Zoellner H

INSTITUCIÓN / INSTITUTION:  - Cellular and Molecular Pathology Research Unit, Dept. Oral Pathology, Westmead Centre for Oral Health, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Australia.

RESUMEN / SUMMARY:  - We recently reported exchange of membrane and cytoplasm during contact co-culture between human Gingival Fibroblasts (h-GF) and SAOS-2 osteosarcoma cells, a process we termed ‘cellular sipping’ to reflect the manner in which cells become  morphologically diverse through uptake of material from the opposing cell type, independent of genetic change. Cellular sipping is increased by Tumor Necrosis Factor-alpha (TNF-alpha), and we here show for the first time altered cytokine synthesis in contact co-culture supporting cellular sipping compared with co-culture where h-GF and SAOS-2 were separated in transwells. SAOS-2 had often undetectably low cytokine levels, while Interleukin-6 (IL-6), Granulocyte Colony  Stimulating Factor (G-CSF) and Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) were secreted primarily by TNF-alpha stimulated h-GF and basic Fibroblast Growth Factor (FGF) was prominent in h-GF lysates (p<0.001). Contact co-cultures permitting cellular sipping had lower IL-6, G-CSF and GM-CSF levels,  as well as higher lysate FGF levels compared with TNF-alpha treated h-GF alone (p<0.05). The opposite was the case for co-cultures in transwells, with increased IL-6, G-CSF and GM-CSF levels (p<0.03) and no clear difference in FGF. We thus demonstrate significant phenotypic change in cultures where cellular sipping occurs, potentially contributing to tumor inflammatory responses.

 

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[112]

TÍTULO / TITLE:  - Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Mar 18. pii: S0046-8177(13)00026-9. doi: 10.1016/j.humpath.2013.01.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2013.01.006

AUTORES / AUTHORS:  - de Graaff MA; Cleton-Jansen AM; Szuhai K; Bovee JV

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.

RESUMEN / SUMMARY:  - Recently, heterozygous mutations in exon 2 of the mediator complex subunit 12 gene have been described in 50% to 70% of uterine leiomyomas; the recurrent nature of these mutations suggests an important role in their pathogenesis. Mediator complex subunit 12 is involved in regulation of transcription and Wnt signaling. So far, little is known about the pathogenesis of the different subtypes of extrauterine leiomyomas and leiomyosarcomas. We performed mutation analysis of mediator complex subunit 12 and immunohistochemistry for beta-catenin, using 69 tumors of 64 patients including 19 uterine leiomyomas, 6 abdominal leiomyomas, 9 angioleiomyomas, 5 piloleiomyomas, and 7 uterine and 23 soft tissue leiomyosarcomas. In line with previous observations, 58% of uterine leiomyomas carried a mediator complex subunit 12 mutation. However, all other extrauterine leiomyomas were negative with the exception of 1 abdominal leiomyoma with a likely primary uterine origin. Of the 30 leiomyosarcomas, only 1 uterine tumor harbored a mutation. A new observation is the identification of 3 tumors with a homozygous mutation; a monosomy X or interstitial deletion was excluded. beta-Catenin immunohistochemistry showed nuclear positivity in only 55% of the mediator complex subunit 12-mutated uterine leiomyomas, suggesting the involvement of pathways other than canonical Wnt signaling in tumorigenesis. Interestingly, 80% of mediator complex subunit 12 wild-type sporadic piloleiomyomas displayed nuclear beta-catenin positivity, indicating its involvement in this leiomyoma subtype. The lack of mediator complex subunit 12 mutations in extrauterine leiomyomas and leiomyosarcomas indicates that these tumors arise through a different pathway, emphasizing the genetic heterogeneity of smooth muscle tumors.

 

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[113]

TÍTULO / TITLE:  - Ionizing radiation exposure and the development of soft-tissue sarcomas in atomic-bomb survivors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Bone Joint Surg Am. 2013 Feb 6;95(3):222-9. doi: 10.2106/JBJS.L.00546.

            ●● Enlace al texto completo (gratuito o de pago) 2106/JBJS.L.00546

AUTORES / AUTHORS:  - Samartzis D; Nishi N; Cologne J; Funamoto S; Hayashi M; Kodama K; Miles EF; Suyama A; Soda M; Kasagi F

INSTITUCIÓN / INSTITUTION:  - Radiation Effects Research Foundation, Hiroshima and Nagasaki, Japan. dsamartzis@msn.com

RESUMEN / SUMMARY:  - BACKGROUND: Very high levels of ionizing radiation exposure have been associated  with the development of soft-tissue sarcoma. The effects of lower levels of ionizing radiation on sarcoma development are unknown. This study addressed the role of low to moderately high levels of ionizing radiation exposure in the development of soft-tissue sarcoma. METHODS: Based on the Life Span Study cohort  of Japanese atomic-bomb survivors, 80,180 individuals were prospectively assessed for the development of primary soft-tissue sarcoma. Colon dose in gray (Gy), the  excess relative risk, and the excess absolute rate per Gy absorbed ionizing radiation dose were assessed. Subject demographic, age-specific, and survival parameters were evaluated. RESULTS: One hundred and four soft-tissue sarcomas were identified (mean colon dose = 0.18 Gy), associated with a 39% five-year survival rate. Mean ages at the time of the bombings and sarcoma diagnosis were 26.8 and 63.6 years, respectively. A linear dose-response model with an excess relative risk of 1.01 per Gy (95% confidence interval [CI]: 0.13 to 2.46; p = 0.019) and an excess absolute risk per Gy of 4.3 per 100,000 persons per year (95% CI: 1.1 to 8.9; p = 0.001) were noted in the development of soft-tissue sarcoma. CONCLUSIONS: This is one of the largest and longest studies (fifty-six years from the time of exposure to the time of follow-up) to assess ionizing radiation effects on the development of soft-tissue sarcoma. This is the first study to suggest that lower levels of ionizing radiation may be associated with the development of soft-tissue sarcoma, with exposure of 1 Gy doubling the risk of soft-tissue sarcoma development (linear dose-response). The five-year survival rate of patients with soft-tissue sarcoma in this population was much lower than  that reported elsewhere.

 

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[114]

TÍTULO / TITLE:  - Dermatofibrosarcoma Protuberans in Childhood Treated with Slow Mohs Micrographic  Surgery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Dermatol. 2013 Feb 22. doi: 10.1111/pde.12039.

            ●● Enlace al texto completo (gratuito o de pago) 1111/pde.12039

AUTORES / AUTHORS:  - Barysch MJ; Weibel L; Neuhaus K; Subotic U; Scharer L; Donghi D; Hafner J; Braun R; Lauchli S; Dummer R; Schiestl C

INSTITUCIÓN / INSTITUTION:  - Department of Plastic and Reconstructive Surgery, University Children’s Hospital  Zurich, Zurich, Switzerland; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland; Children’s Research Center, Zurich, Switzerland.

RESUMEN / SUMMARY:  - Dermatofibrosarcoma protuberans (DFSP) in childhood is a rare tumor with high recurrence rates. Wide local excision can result in disfiguring mutilation, whereas Mohs micrographic surgery (MMS) reduces surgical margins. MMS in children is not performed routinely, as the required infrastructures such as a histopathology lab in close proximity to the operating room is often lacking. We  retrospectively reviewed children diagnosed with DFSP treated at our hospital over 2 years. We recorded surgical treatment details, including margins, duration of inpatient stay, outcome, follow-up, and molecular genetic tumor tissue analysis. Four children with a median age of 6.8 years (range 6.0-8.8 years) were identified who had a diagnostic delay of a median of 2.5 years (range 0.5-4.0 years); all underwent complete tumor excision using the slow MMS technique using  vacuum-assisted closure systems between repeated excisions and before wound closure. The median maximal safety margins were 1.5 cm (range 1.0-3.0 cm). By using vacuum-assisted closure systems, no dressing changes were needed, pain was  limited, and full mobility was maintained in all children. The median total time  in the hospital was 11 days (range 10-14 days). No relapses occurred during a median follow-up of 25.8 months (range 11.3-32.6 months). Collagen 1A1/platelet-derived growth factor B (COL1A1/PDGFB) translocation on chromosomes  17 and 22 was detected in all three analyzable specimens. Lesions suspected of being DFSP warrant prompt histologic evaluation; interdisciplinary management is  mandatory in particular for children. Micrographic surgery allows smaller surgical margins than wide excision and should be considered as the treatment of  choice in children with DFSP. The interim usage of vacuum-assisted closure systems increases patient comfort. Translocations in the COL1A1/PDGFB gene imply  susceptibility to targeted treatment modalities for therapy-resistant cases.

 

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[115]

TÍTULO / TITLE:  - An unusual case of severe aortic valve stenosis in an adult caused by aortic valve inflammatory myofibroblastic tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Thorac Cardiovasc Surg. 2013 Feb 9. pii: S0022-5223(13)00056-1. doi: 10.1016/j.jtcvs.2013.01.028.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jtcvs.2013.01.028

AUTORES / AUTHORS:  - Zhao D; Wang C; Guo C

INSTITUCIÓN / INSTITUTION:  - Department of Cardiac Surgery, Zhongshan Hospital Fudan University and Shanghai Institute of Cardiovascular Diseases, Shanghai, People’s Republic of China.

 

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[116]

TÍTULO / TITLE:  - Induction of Cell Cycle Arrest and Apoptosis in Human Osteosarcoma U-2 OS Cells by Solanum lyratum Extracts.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nutr Cancer. 2013 Apr;65(3):469-79. doi: 10.1080/01635581.2013.757627.

            ●● Enlace al texto completo (gratuito o de pago) 1080/01635581.2013.757627

AUTORES / AUTHORS:  - Lin YT; Huang AC; Kuo CL; Yang JS; Lan YH; Yu CC; Huang WW; Chung JG

INSTITUCIÓN / INSTITUTION:  - a Department of Biological Science and Technology , China Medical University , Taichung , Taiwan.

RESUMEN / SUMMARY:  - This research focused on a Chinese herb medicine, Solanum lyratum Thunb (Solanaceae) by ethanol extracts (SLE) for investigating the molecular anticancer mechanism in vitro for exploring the means of cell death through the effects on mitochondrial function. We found that SLE induced cytotoxic effects in human osteosacroma U-2 OS cells, and these effects include cell morphological changes,  a decrease of the percentage of viable cells and induction of apoptosis. The results suggest that cell death induced by SLE is closely related to apoptosis based on the observations of DAPI staining and sub-G1 phase in U-2 OS cells. Flow cytometric assays also showed that SLE promoted the production of reactive oxygen species and nitric oxide but decreased the levels of mitochondrial membrane potential and promoted the activations of caspase-8 and -9 in U-2 OS cells. SLE inhibited the level of Bcl-2 but promoted the Bax level, and both proteins led to the release of cytochrome c from mitochondria to cytosol and activation of caspase-9 and -3, resulting in the apoptotic death which is mediated through the  mitochondrial pathway. Taken together, SLE was demonstrated to be effective in killing U-2 OS osteosacroma cells via the ROS-promoted and mitochondria- and caspase-dependent apoptotic pathways.

 

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[117]

TÍTULO / TITLE:  - Diagnostic value of investigating GNAS mutations in fibro-osseous lesions: a retrospective study of 91 cases of fibrous dysplasia and 40 other fibro-osseous lesions.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mod Pathol. 2013 Feb 1. doi: 10.1038/modpathol.2012.223.

            ●● Enlace al texto completo (gratuito o de pago) 1038/modpathol.2012.223

AUTORES / AUTHORS:  - Tabareau-Delalande F; Collin C; Gomez-Brouchet A; Decouvelaere AV; Bouvier C; Larousserie F; Marie B; Delfour C; Aubert S; Rosset P; de Muret A; Pages JC; de Pinieux G

INSTITUCIÓN / INSTITUTION:  - 1] Department of Pathology, Tours University Hospital and University Francois Rabelais, Tours, France [2] Laboratory of Biochemistry and Molecular Biology, Trousseau University Hospital and University Francois Rabelais, Tours, France.

RESUMEN / SUMMARY:  - GNAS (guanine nucleotide-binding protein/alpha-subunit) mutations that induce the activation of G-protein alpha-subunit participate in the pathogenesis of fibrous  dysplasia. The aim of this study was to evaluate the sensitivity and specificity  of GNAS mutations in fibrous dysplasia and other fibro-osseous lesions, to assess the value of investigating this mutation in the diagnosis of fibro-osseous lesions. We studied 91 cases of fibrous dysplasia. The quality and/or quantity of genomic DNA were suitable for molecular analysis for 51 cases of fibrous dysplasia. GNAS mutations were investigated by three techniques: high-resolution  melting (exon 8), allele-specific PCR (exons 8 and 9) and/or direct DNA sequencing (exons 8 and 9). Fibrous dysplasia samples were classified blind to the GNAS mutation status into six histological subtypes as conventional, fibro-involutive, osteosclerosing, cementifying, osteocartilaginous and with prominent aneurysmal cystic changes. We also studied 14 cases of low-grade osteosarcoma, 21 cases of ossifying fibroma, 3 cases of osteofibrous dysplasia, 1 case of osseous dysplasia of the jawbone and 1 post-traumatic lesion of the ribs. Twenty-three cases of fibrous dysplasia (45%) showed mutations of codon 201 (exon 8, p.R201H or p.R201C). No mutation was found on codon 227 (exon 9). GNAS mutations in conventional fibrous dysplasia were detected in the same proportion  (47%) as in the other histological subtypes (47%, P=0.96), regardless of sex (P=0.44), age (P=0.90) and location (P=1). GNAS mutations were not detected in any other fibro-osseous lesions. The GNAS mutation was thus specific to fibrous dysplasia in the context of fibro-osseous lesions. The particular mosaicism of mutant and non-mutant cells within the lesion or the existence of other mutations not already described could explain the lack of GNAS mutation in cases of fibrous dysplasia. Investigating this mutation may constitute a valuable complementary diagnostic tool, despite its low sensitivity, particularly in unconventional morphologically different subtypes of fibrous dysplasia.Modern Pathology advance  online publication, 1 February 2013; doi:10.1038/modpathol.2012.223.

 

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[118]

TÍTULO / TITLE:  - Critical appraisal of volumetric-modulated arc therapy compared with electrons for the radiotherapy of cutaneous Kaposi’s sarcoma of lower extremities with bone sparing.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Radiol. 2013 Mar;86(1023):20120543. doi: 10.1259/bjr.20120543. Epub 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1259/bjr.20120543

AUTORES / AUTHORS:  - Nicolini G; Abraham S; Fogliata A; Jordaan A; Clivio A; Vanetti E; Cozzi L

INSTITUCIÓN / INSTITUTION:  - Medical Physics Unit, Radiotherapy Department, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. giorgia.nicolini@eoc.ch

RESUMEN / SUMMARY:  - OBJECTIVE: To evaluate the use of volumetric-modulated arc therapy [VMAT, RapidArc® (RA); Varian Medical Systems, Palo Alto, CA] for the treatment of cutaneous Kaposi’s sarcoma (KS) of lower extremities with adequate target coverage and high bone sparing, and to compare VMAT with electron beam therapy. METHODS: 10 patients were planned with either RA or electron beams. The dose was  prescribed to 30 Gy, 10 fractions, to mean the planning target volume (PTV), and  significant maximum dose to bone was limited to 30 Gy. Plans were designed for 6-MV photon beams for RA and 6 MeV for electrons. Dose distributions were computed with AcurosXB® (Varian Medical Systems) for photons and with a Monte Carlo algorithm for electrons. RESULTS: V(90%) was 97.3+/-1.2 for RA plans and 78.2+/-2.6 for electrons; similarly, V(107%) was 2.5+/-2.2 and 37.7+/-3.4, respectively. RA met coverage criteria. Concerning bone sparing, D(2%) was 29.6+/-1.1 for RA and 31.0+/-2.4 for electrons. Although acceptable for bone involvement, pronounced target coverage violations were obtained for electron plans. Monitor units were similar for electrons and RA, although for the latter they increased when superior bone sparing was imposed. Delivery times were 12.1+/-4.0 min for electrons and 4.8+/-1.3 min for the most modulated RA plans. CONCLUSION: High plan quality was shown for KS in the lower extremities using VMAT, and this might simplify their management in comparison with the more conventional usage of electrons, particularly in institutes with limited staff resources and heavy workloads. ADVANCES IN KNOWLEDGE: VMAT is also dosimetrically extremely advantageous in a typology of treatments where electron beam therapy is mainly considered to be effective owing to the limited penetration of the beams.

 

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[119]

TÍTULO / TITLE:  - Overexpression of Integrin-beta1 in Leiomyoma Promotes Cell Spreading and Proliferation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Endocrinol Metab. 2013 Mar 12.

            ●● Enlace al texto completo (gratuito o de pago) 1210/jc.2012-3647

AUTORES / AUTHORS:  - Chen HM; Lin YH; Cheng YM; Wing LY; Tsai SJ

INSTITUCIÓN / INSTITUTION:  - Institute of Basic Medical Sciences (H.-M.C., L.-Y.C.W., S.-J.T.) and Departments of Physiology (Y.-H.L., L.-Y.C.W., S.-J.T.) and Obstetrics and Gynecology (Y.-M.C.), College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.

RESUMEN / SUMMARY:  - Context:Uterine leiomyoma, the most common tumors found in the women of the reproductive age, may cause abnormal uterine bleeding and be life threatening. Compared with myometrium, leiomyoma contains excessive extracellular matrix (ECM). However, the pathological roles of ECM in the development of leiomyoma remain largely unknown. Integrins are the major adhesion molecules on cell surface to interact with ECM. The interactions of ECM with integrins regulate cell adhesion and initiate signals for cell growth, differentiation, and migration.Objective:The aim of this study was to investigate the expression and functional role of integrin-beta1 in leiomyoma pathogenesis.Design:Levels of integrin-beta1 protein were determined by Western blotting in paired normal and leiomyomal tissues (n = 15). Knockdown of integrin-beta1 and inhibition of ECM-integrin interaction by disintegrin were used to evaluate the impact of integrin-beta1 in cell adhesion, spreading, and proliferation.Results:Levels of integrin-beta1 were significantly up-regulated in leiomyomal cells compared with  their normal counterparts. Knockdown of integrin-beta1 did not affect cell adhesion on fibronectin or laminin matrix but significantly inhibits cell spreading ability. Consistent with this notion, the phosphorylation of focal adhesion kinase and the recruitment of paxillin to the focal contact were decreased in integrin-beta1 knockdown cells, which attenuates contraction force.  The inability of cell spreading leads to inhibition of cyclin D1 expression and impedes cell cycle progression. More importantly, disruption of ECM-integrin interaction by the small protein, disintegrin inhibited cyclin D1 expression and  cell proliferation.Conclusion:These data demonstrate that integrin-beta1 is a critical ligand to enhance cell-ECM contact force and thus promotes cell proliferation. Disruption of ECM-integrin-beta1 signaling may serve as an option  to inhibit the progression of leiomyoma.

 

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[120]

TÍTULO / TITLE:  - Chemical constituents of volatile oil from Pyrolae herba and antiproliferative activity against SW1353 human chondrosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Oncol. 2013 Apr;42(4):1452-8. doi: 10.3892/ijo.2013.1816. Epub 2013 Feb 8.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ijo.2013.1816

AUTORES / AUTHORS:  - Cai L; Ye H; Li X; Lin Y; Yu F; Chen J; Li H; Liu X

INSTITUCIÓN / INSTITUTION:  - Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China.

RESUMEN / SUMMARY:  - The objective of the present study was to identify chemical constituents of volatile oil from Pyrolae herba (PHVO) and evaluate the antiproliferative activity of PHVO against SW1353 human chondrosarcoma cells. The volatile oil from Pyrolae herba was prepared by hydrodistillation and characterized by gas chromatography-mass spectroscopy (GC-MS). A total of 12 components in PHVO were identified representing 81.62% of the total integrated chromatographic peaks. The major compounds were found to be n-hexadecanoic acid (29.29%), cedrol (17.08%), 6,10,14-trimethyl-2-pentadecanone (9.59%) and cis-9-octadecadienoic acid (8.23%). The antiproliferative activity of PHVO against SW1353 cells was investigated using MTT assay, flow cytometry and western blot analysis. Our results demonstrated that PHVO inhibited SW1353 cell viability in a dose- and time-dependent manner. Furthermore, PHVO treatment decreased the number of cells  entering the S phase and caused a reduction in the expression of cyclin D1, cyclin-dependent kinase (CDK)4 and CDK6, whereas it caused an increase in the expression of p21. PHVO demonstrated potent antitumor activity against SW1353 cells, suggesting its potential use as a therapeutic agent in the treatment of chondrosarcoma.

 

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[121]

TÍTULO / TITLE:  - Silencing SATB1 inhibits proliferation of human osteosarcoma U2OS cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Cell Biochem. 2013 Mar 21.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11010-013-1591-0

AUTORES / AUTHORS:  - Zhang H; Qu S; Li S; Wang Y; Li Y; Wang Y; Wang Z; Li R

INSTITUCIÓN / INSTITUTION:  - Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of  Medicine, Jilin University, Changchun, 130021, People’s Republic of China.

RESUMEN / SUMMARY:  - It has been shown that over-expression of Special AT-rich binding protein 1 (SATB1) in breast cancer predicts a poor prognosis. This study was aimed at investigating the effects of silencing SATB1 on mesenchymal derived human osteosarcoma U2OS cells and the underlying mechanisms. The expressions of SATB1 and the related genes in the cells were detected by qRT-PCR and/or Western Blotting. SATB1 silencing was achieved by stable transfection with the vectors expressing small hairpin RNA versus SATB1. Cell proliferation was detected in a microplate reader with Cell Counting Kit-8 and the cell cycle was analyzed by flow cytometry using a cell cycle detection kit. The study found that SATB1 was particularly over-expressed in human osteosarcoma U2OS. Silencing SATB1 inhibited the proliferation of U2OS. It was found that inhibition of cell proliferation resulted from cell cycle arrest due to down-regulated expression of CFGF and JunB. The over-expression of SATB1 is responsible for abnormal proliferation of mesenchymal derived human Osteosatcoma U2OS cells, indicating that silencing SATB1 expression in the cells might be developed as an efficient osteosarcoma therapy. CTGF and JunB were involved in SATB1-mediated proliferation of U2OS cells.

 

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[122]

TÍTULO / TITLE:  - Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2013 Mar;37(3):453-8. doi: 10.1097/PAS.0b013e31828446d6.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e31828446d6

AUTORES / AUTHORS:  - Kim YS; Wu H; Pawlowska AB; Bautista-Quach MA; Huang Q; Gaal K; Chang KL

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010,  USA. ykim@coh.org

RESUMEN / SUMMARY:  - Mast cell sarcoma (MCS) is an extremely rare neoplasm with a clinically aggressive course. Because of its rarity, its morphologic and molecular characteristics are still not well defined. We report a case of a 15-year-old girl with MCS of the temporal bone extending into the posterior fossa creating a  mass effect. The lesion mimicked a histiocytic neoplasm morphologically, but showed a novel KIT missense mutation, L799F (2395 C>T). The KIT D816V mutation is frequently found in systemic mastocytosis, but it has not been documented in the  few reported human MCS cases. However, 1 reported case of MCS has shown a different alteration in the KIT gene. Our case is the first MCS case with L799F mutation, located between the catalytic loop (790 to 797) and the activation loop (810 to 837) of the KIT gene, and only the second case of MCS with KIT mutation documented in the literature. Proximity of the L799F mutation to the enzymatic region of the KIT tyrosine kinase domain may induce resistance to tyrosine kinase inhibitors.

 

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[123]

TÍTULO / TITLE:  - Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cell Prolif. 2013 Apr;46(2):127-36. doi: 10.1111/cpr.12021.

            ●● Enlace al texto completo (gratuito o de pago) 1111/cpr.12021

AUTORES / AUTHORS:  - Poplineau M; Doliwa C; Schnekenburger M; Antonicelli F; Diederich M; Trussardi-Regnier A; Dufer J

INSTITUCIÓN / INSTITUTION:  - Unite MEDyC, URCA-CNRS FRE 3481, SFR Cap-Sante, Faculte de Pharmacie, Universite  de Reims, Reims, France.

RESUMEN / SUMMARY:  - OBJECTIVE: Chromatin texture patterns of tumour cell nuclei can serve as cancer biomarkers, either to define diagnostic classifications or to obtain relevant prognostic information, in a large number of human tumours. Epigenetic mechanisms, mainly DNA methylation and histone post-translational modification, have been shown to influence chromatin packing states, and therefore nuclear texture. The aim of this study was to analyse effects of these two mechanisms on  chromatin texture, and also on correlation with gelatinase expression, in human fibrosarcoma tumour cells. MATERIALS AND METHODS: We investigated effects of DNA  hypomethylating agent 5-aza-2’-deoxycytidine (5-azadC) and histone deacetylase inhibitor trichostatin A (TSA) on nuclear textural characteristics of human HT1080 fibrosarcoma cells, evaluated by image cytometry, and expression of gelatinases MMP-2 and MMP-9, two metalloproteinases implicated in cancer progression and metastasis. RESULTS: 5-azadC induced significant variation in chromatin higher order organization, particularly chromatin decondensation, associated with reduction in global DNA methylation, concomitantly with increase  in MMP-9, and to a lesser extent, MMP-2 expression. TSA alone did not have any effect on HT1080 cells, but exhibited differential activity when added to cells treated with 5-azadC. When treated with both drugs, nuclei had higher texture abnormalities. In this setting, reduction in MMP-9 expression was observed, whereas MMP-2 expression remained unaffected. CONCLUSIONS: These data show that hypomethylating drug 5-azadC and histone deacetylase inhibitor TSA were able to induce modulation of higher order chromatin organization and gelatinase expression in human HT1080 fibrosarcoma cells.

 

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[124]

TÍTULO / TITLE:  - The Combination of Sorafenib and Everolimus abrogates mTORC-1 and mTORC2 up-regulation in preclinical models of Osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Cancer Res. 2013 Feb 22.

            ●● Enlace al texto completo (gratuito o de pago) 1158/1078-0432.CCR-12-2293

AUTORES / AUTHORS:  - Pignochino Y; Dell’aglio C; Basirico M; Capozzi F; Soster M; Marchio S; Bruno S; Gammaitoni L; Sangiolo D; Torchiaro E; D’Ambrosio L; Fagioli F; Ferrari S; Alberghini M; Picci P; Aglietta M; Grignani G

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, University of Torino Medical School, Institute for Cancer Research and Treatment.

RESUMEN / SUMMARY:  - PURPOSE: The multikinase inhibitor sorafenib displays antitumor activity in preclinical models of osteosarcoma. However, in sorafenib-treated metastatic-relapsed osteosarcoma patients, disease stabilization and tumor shrinkage were short-lived and drug resistance occurred. We explored the sorafenib treatment escape mechanisms to overcome their drawbacks. Experimental design: Immunoprecipitation, Western blotting, and immunohistochemistry were employed to analyze the mammalian target of rapamycin (mTOR) pathway (mTORC1 and  mTORC2). Cell viability, colony growth, and cell migration were evaluated in different osteosarcoma cell lines (MNNG-HOS, HOS, KHOS/NP, MG63, U-2OS, SJSA-1, SAOS-2) after scalar dose treatment with sorafenib (10-0.625 muM), rapamycin-analog everolimus (100-6.25 nM), and combinations of the two. Cell cycle, reactive oxygen species (ROS) production, and apoptosis were assessed by flow cytometry. NOD/SCID mice injected with MNNG-HOS cells were utilized to determine anti-tumor and anti-metastatic effects. Angiogenesis and vascularization were evaluated in vitro by exploiting endothelial branching morphogenesis assays and in vivo in xenografted mice and chorioallantoic membranes. RESULTS: After sorafenib treatment, mTORC1 signaling was reduced (downstream target P-S6) while mTORC2 was increased (phospho-mTOR Ser2481) in MNNG-HOS xenografts compared to vehicle-treated mice. Combining sorafenib with everolimus resulted in complete abrogation of both mTORC1 (through ROS-mediated AMPK activation) and mTORC2 (through complex disassembly). The sorafenib/everolimus combination yielded: 1) enhanced anti-proliferative and pro-apoptotic effects, 2) impaired tumor growth, 3) potentiated anti-angiogenesis, and 4) reduced migratory and metastatic potential. CONCLUSION: mTORC2 activation is an escape mechanism from sorafenib treatment. When sorafenib is combined with everolimus, its anti-tumor activity is increased by complete inhibition of the mTOR pathway in the preclinical setting.

 

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[125]

TÍTULO / TITLE:  - Osteoblastic potency of bone marrow cells cultivated on functionalized biometals  with cyclic RGD-peptide.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Biomed Mater Res A. 2013 Mar 25. doi: 10.1002/jbm.a.34590.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jbm.a.34590

AUTORES / AUTHORS:  - Jager M; Boge C; Janissen R; Rohrbeck D; Hulsen T; Lensing-Hohn S; Krauspe R; Herten M

INSTITUCIÓN / INSTITUTION:  - Orthopaedic Department, University of Duisburg-Essen, Germany; Orthopaedic Department, Heinrich-Heine-University Medical School, Dusseldorf, Germany.

RESUMEN / SUMMARY:  - The fixation of cementless endoprostheses requires excellent fixation at the bone implant interface. Although the surface structures of these implants are designed to promote osteoblastic differentiation, poor bone quality may prevent or delay osseointegration. There is evidence that RGD peptides known as recognition motifs for various integrins, promote cellular adhesion, influence cellular proliferation, and differentiation of local cells. In this study, five different  metal surfaces were analyzed: Sandblasted (TiSa) and polished (TiPol) Ti6Al4V, porocoated (CCPor) and polished (CCPol) cobalt chrome and polished stainless steel (SS) were coated by ethanol amine and poly(ethylene glycol) to attach covalently RGD peptides. Human mesenchymal stromal cells of healthy donors were cultivated onto prior functionalized metal surfaces for 14 days without osteogenic stimulation. Cell proliferation and differentiation were quantitatively evaluated for native (I), NaOH pre-activated (II), NaOH pre-activated, and PEG-coated (III) as well as for RGD (IV) coated surfaces. The  RGD immobilization efficiency was analyzed by epi-fluorescence spectroscopy, cell morphology was documented by light and scanning electron microscopy. The RGD-binding efficiency was TiSa > TiPol > SS > CCPor > CCPol. RGD coated surfaces showed the highest average cell proliferation on CCPol > SS > CCPor > TiSa >/= TiPol, whereas cellular differentiation mostly correlated with the observed proliferation results, such as CCPol > TiSa > SS > CCPor > TiPol. Considering statistical analyses (significance level of alpha = 0.05), the RGD-coating of all biometals in comparison and in respect of their particular controls showed no significant improvement in cellular proliferation and osteoblastic differentiation. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

 

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[126]

TÍTULO / TITLE:  - NAD(P)H Quinone Oxidoreductase 1 (NQO1)-Bioactivated Pronqodine A Regulates Prostaglandin Release from Human Synovial Sarcoma Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Nat Prod. 2013 Feb 20.

            ●● Enlace al texto completo (gratuito o de pago) 1021/np300643f

AUTORES / AUTHORS:  - Nakae K; Adachi H; Sawa R; Hosokawa N; Hatano M; Igarashi M; Nishimura Y; Akamatsu Y; Nomoto A

INSTITUCIÓN / INSTITUTION:  - Institute of Microbial Chemistry (BIKAKEN) , 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.

RESUMEN / SUMMARY:  - Natural products have contributed to the elucidation of biological mechanisms as  well as drug discovery research. Even now, the expectation for natural products is undiminished. We screened prostaglandin release inhibitors that had no effect  on in vitro cyclooxygenase activity derived from natural product sources and discovered pronqodine A. Using spectral analysis and total synthesis, the structure of pronqodine A was shown to be a benzo[d]isothiazole-4,7-dione analogue. Evaluation of the biological activity of pronqodine A revealed that the NAD(P)H dehydrogenase quinone 1 (NQO1) converted pronqodine A into a two-electron reductive form. The reductive form underwent autoxidation and reversed to its native form immediately with the generation of reactive oxygen species. Further investigations proved that pronqodine A inhibited cyclooxygenase enzyme activity  only in the presence of NQO1. Pronqodine A acts as a potential bioreductive compound, inhibiting prostaglandin release in selectively activated NQO1-expressing cells.

 

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[127]

TÍTULO / TITLE:  - Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr503.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Lab Invest. 2013 Mar 4. doi: 10.1038/labinvest.2013.43.

            ●● Enlace al texto completo (gratuito o de pago) 1038/labinvest.2013.43

AUTORES / AUTHORS:  - Liu NN; Ohkouchi M; Hashikura Y; Kajimoto N; Matsuda I; Isozaki K; Toh Y; Takahashi T; Nishida T; Hirota S

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.

RESUMEN / SUMMARY:  - The great majority of gastrointestinal stromal tumors (GISTs) have gain-of-function mutations of the c-kit gene, which encodes KIT receptor tyrosine kinase. Most of the mutations are located at exon 11, but some are at exon 9 or at other exons. Mutation types at exon 11 vary, while most mutations at exon 9 are a particular duplication of Ala502Tyr503 (KIT-Dup-Ala502Tyr503). Recently a duplication of Ser501Ala502 (KIT-Dup-Ser501Ala502) at exon 9 has been reported in two cases of pediatric mastocytosis and one case of adult mast cell leukemia. Although KIT-Dup-Ser501Ala502 had not been reported in GISTs, we found two GIST cases possessing the mutation in 45 GIST cases with exon 9 c-kit gene mutations,  among a total of approximately 500 GIST cases examined. In this report, we briefly summarize clinicopathological findings of the two cases, and characterize the biology of the mutation. When autophosphorylation of KIT-Dup-Ser501Ala502 was examined by transient transfection of c-kit cDNA with Dup-Ser501Ala502 into CHO-K1 cells, KIT-Dup-Ser501Ala502 was ligand-independently activating. The inhibitory effect of selective tyrosine kinase inhibitors, imatinib and nilotinib, on KIT-Dup-Ser501Ala502 was examined and compared with that of KIT-Dup-Ala502Tyr503. Imatinib efficiently inhibited constitutive activation of KIT-Dup-Ser501Ala502 at a concentration of 0.1 muM, whereas it inhibited that of  KIT-Dup-Ala502Tyr503 at a concentration of 10 muM. Constitutive activation of KIT-Dup-Ser502Ala503 was not inhibited by nilotinib even at a concentration of 10 muM but that of KIT-Dup-Ala501Tyr502 was almost completely inhibited at a concentration of 1 muM. The results suggest that imatinib and nilotinib could be  more effective on GISTs with KIT-Dup-Ser501Ala502 than those with KIT-Dup-Ala502Tyr503. In fact, a patient with KIT-Dup-Ser501Ala502 showed long-term stable disease with administration of the usual dose of 400 mg imatinib. Although mutation sites of KIT-Dup-Ser501Ala502 and KIT-Dup-Ala502Tyr503 are closely located, imatinib- and nilotinib-sensitive KIT-Dup-Ser501Ala502 are distinguishable from KIT-Dup-Ala502Tyr503.Laboratory Investigation advance online publication, 4 March 2013; doi:10.1038/labinvest.2013.43.

 

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[128]

TÍTULO / TITLE:  - Similarities in the Endocrine-Disrupting Potencies of Indoor Dust and Flame Retardants by Using Human Osteosarcoma (U2OS) Cell-Based Reporter Gene Assays.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Environ Sci Technol. 2013 Mar 19;47(6):2898-908. doi: 10.1021/es304691a. Epub 2013 Mar 1.

            ●● Enlace al texto completo (gratuito o de pago) 1021/es304691a

AUTORES / AUTHORS:  - Suzuki G; Tue NM; Malarvannan G; Sudaryanto A; Takahashi S; Tanabe S; Sakai S; Brouwer A; Uramaru N; Kitamura S; Takigami H

INSTITUCIÓN / INSTITUTION:  - Center for Material Cycles and Waste Management Research, National Institute for  Environmental Studies , Tsukuba, Japan, Tsukuba 305-8506, Japan.

RESUMEN / SUMMARY:  - Indoor dust is a sink for many kinds of pollutants, including flame retardants (FRs), plasticizers, and their contaminants and degradation products. These pollutants can be migrated to indoor dust from household items such as televisions and computers. To reveal high-priority end points of and contaminant  candidates in indoor dust, using CALUX reporter gene assays based on human osteosarcoma (U2OS) cell lines, we evaluated and characterized the endocrine-disrupting potencies of crude extracts of indoor dust collected from Japan (n = 8), the United States (n = 21), Vietnam (n = 10), the Philippines (n = 17), and Indonesia (n = 10) and for 23 selected FRs. The CALUX reporter gene assays used were specific for compounds interacting with the human androgen receptor (AR), estrogen receptor alpha (ERalpha), progesterone receptor (PR), glucocorticoid receptor (GR), and peroxisome proliferator-activated receptor gamma2 (PPARgamma2). Indoor dust extracts were agonistic to ERalpha, GR, and PPARgamma2 and antagonistic against AR, PR, GR, and PPARgamma2. In comparison, a  majority of FRs was agonistic to ERalpha and PPARgamma2 only, and some FRs demonstrated receptor-specific antagonism against all tested nuclear receptors. Hierarchical clustering clearly indicated that agonism of ERalpha and antagonism  of AR and PR were common, frequently detected end points for indoor dust and tested FRs. Given our previous results regarding the concentrations of FRs in indoor dust and in light of our current results, candidate contributors to these  effects include not only internationally controlled brominated FRs but also alternatives such as some phosphorus-containing FRs. In the context of indoor pollution, high-frequency effects of FRs such as agonism of ERalpha and antagonism of AR and PR are candidate high-priority end points for further investigation.

 

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[129]

TÍTULO / TITLE:  - Familial multiple discoid fibromas: unique histological features and therapeutic  response to topical rapamycin.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Dermatol. 2013 Mar 18. doi: 10.1111/bjd.12315.

            ●● Enlace al texto completo (gratuito o de pago) 1111/bjd.12315

AUTORES / AUTHORS:  - Wee JS; Chong H; Natkunarajah J; Mortimer PS; Moosa Y

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, St George’s Hospital, London, U.K.

RESUMEN / SUMMARY:  - Familial multiple discoid fibromas (FMDF) is a rare genodermatosis that bears some resemblance to Birt-Hogg-Dube syndrome (BHD) but is not associated with FLCN (folliculin) mutations or systemic manifestations. It is characterised by the development of papules over the face and pinnae early in life. Histological findings are fibrovascular tumours adjacent to hair follicles without the features of fibrofolliculomas, which have been termed discoid fibromas. We present siblings with multiple papules over the face and pinnae that developed in childhood. Histological specimens from both siblings demonstrated discoid fibromas, but with some lesions exhibiting an unusual keloidal-like pattern with  thick hyalinised collagen fibres surrounded by plump spindle and histiocyte-like  cells. FLCN gene mutations were not found. We report on clinical improvement with topical rapamycin solution (1mg/1ml) applied daily to the face for 4 months. Therapeutic response to topical rapamycin may provide a clue to the underlying genetic basis of this condition.

 

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[130]

TÍTULO / TITLE:  - Efficacy and safety of daily repeated sonographically guided high-intensity focused ultrasound treatment of uterine fibroids: preliminary study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Ultrasound Med. 2013 Mar;32(3):397-406.

AUTORES / AUTHORS:  - Cho JY; Kim SH; Kim SY; Moon SK; Li J

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Korea. radjycho@snu.ac.kr

RESUMEN / SUMMARY:  - OBJECTIVES: To evaluate the efficacy and safety of repeated low-dose sonographically guided high-intensity focused ultrasound (HIFU) treatment of uterine fibroids. METHODS: Between April and December 2010, 24 consecutive premenopausal women with symptomatic uterine fibroids were enrolled in this study. The treatment was performed with an HIFU unit without anesthesia or sedative administration and Foley catheter insertion. The treatment was performed 40 to 70 min/d according to the tumor volume. The entire treatment was finished after 4 to 6 days of treatment. We assessed the differences in the symptom severity score, tumor volume, and contrast-enhanced volume at baseline and 1 and  3 months after treatment. The clinical success rates according to tumor volume and contrast-enhanced volume reductions and echogenicity and vascular flow changes were analyzed. The clinical success rates according to the baseline characteristics of fibroids were analyzed. We assessed adverse events during and  after treatment. RESULTS: The symptom severity score, tumor volume, and contrast-enhanced volume decreased significantly after repeated low-dose HIFU treatment (P < .05). There were significant correlations between tumor volume and contrast-enhanced volume reduction and the decrease in the symptom severity score. The clinical success rates were significantly different according to the tumor vascularity on color Doppler sonography and the degree of enhancement on magnetic resonance imaging. Skin burns and other serious adverse events did not develop. CONCLUSIONS: Although this preliminary report had several limitations, daily repeated HIFU treatment of uterine fibroids may be a useful and safe method and can be used as a different option for HIFU treatment in patients who prefer treatment without anesthesia or sedation.

 

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[131]

TÍTULO / TITLE:  - CT-based response assessment of advanced gastrointestinal stromal tumor: Dual energy CT provides a more predictive imaging biomarker of clinical benefit than RECIST or Choi criteria.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Radiol. 2013 Feb 11. pii: S0720-048X(13)00016-8. doi: 10.1016/j.ejrad.2013.01.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejrad.2013.01.006

AUTORES / AUTHORS:  - Meyer M; Hohenberger P; Apfaltrer P; Henzler T; Dinter DJ; Schoenberg SO; Fink C

INSTITUCIÓN / INSTITUTION:  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. Electronic address: mr.meyer.mathias@gmail.com.

RESUMEN / SUMMARY:  - OBJECTIVES: Dual-energy CT (DECT) allows quantification of intravenously injected iodinated contrast media in tumors, and therefore may be considered as a surrogate marker for perfusion and tumor vascularity. This study evaluated whether newly developed DECT response criteria allow better correlation with survival than established response criteria. METHODS: Seventeen patients with advanced GIST treated with tyrosine-kinase-inhibitors were assessed by contrast-enhanced DECT 2 and 6 months after beginning of treatment. Response to treatment of 165 tumor lesions was evaluated according to RECIST, Choi criteria and newly developed DECT criteria, defining non-responders as an increase of both tumor size >20% and iodine related attenuation or either a >50% increase of tumor size or iodine related attenuation. All other patients were classified as responders. Progression-free survival (PFS) and overall survival (OS) were calculated by Kaplan-Meier analysis. RESULTS: Choi criteria and DECT showed a significantly longer median PFS of patients rated as responders than patients rated as non-responders (9-29 months vs. 2-6 months; p<0.02) at follow-up. Only DECT analysis at 6 months follow-up allowed a valid prediction of OS. CONCLUSION: This study indicates that DECT allows a better prediction of therapeutic benefit  in advanced GIST patients treated with tyrosine-kinase-inhibitors than established response criteria. However, the most important predictive biomarker of therapeutic benefit was absence of progression, no matter which response evaluation criteria were applied.

 

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[132]

TÍTULO / TITLE:  - Solitary Fibrous Tumor of the Sinonasal Cavity: CT and MR Imaging Findings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - AJNR Am J Neuroradiol. 2013 Feb 14.

            ●● Enlace al texto completo (gratuito o de pago) 3174/ajnr.A3485

AUTORES / AUTHORS:  - Yang BT; Song ZL; Wang YZ; Dong JY; Wang ZC

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China; and Department of Radiology, Zaozhuang Municipal Hospital, Shandong Province, China.

RESUMEN / SUMMARY:  - SUMMARY:SFT is a rare lesion of the sinonasal cavity. We retrospectively reviewed 5 patients with histopathologically proved sinonasal SFTs to determine their CT and MR imaging features. All patients underwent paranasal sinus CT and MR imaging. Four SFTs occurred in the nasal cavity, and 1, in the maxillary sinus. All SFTs had well-defined margins, and the mean maximum diameter was 55 mm. On nonenhanced CT, 5 SFTs appeared homogeneously isoattenuating to gray matter. The  most common manifestations of bony involvement were bony remodeling and thinning. On MR imaging, 5 SFTs were isointense to gray matter on T1-weighted images, and the lesions were isointense in 3 and hypointense in 2 patients on T2-weighted images. The lesions showed heterogeneously marked enhancement on postenhanced MR  images. Four patients underwent dynamic contrast-enhanced MR imaging, and the TICs showed a washout pattern. A familiarity with the imaging findings of sinonasal SFT may help to diagnose this entity.

 

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[133]

TÍTULO / TITLE:  - Effect of long term imatinib on bone in adults with chronic myelogenous leukemia  and gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Leuk Res. 2013 Mar 5. pii: S0145-2126(13)00043-X. doi: 10.1016/j.leukres.2013.02.005.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.leukres.2013.02.005

AUTORES / AUTHORS:  - Berman E; Girotra M; Cheng C; Chanel S; Maki R; Shelat M; Strauss HW; Fleisher M; Heller G; Farooki A

INSTITUCIÓN / INSTITUTION:  - Leukemia Service, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, NY, USA. Electronic address: bermane@mskcc.org.

RESUMEN / SUMMARY:  - Patients with chronic myelogenous leukemia (CML) or gastrointestinal stromal tumors (GIST) who take imatinib have abnormalities of bone metabolism. However, it is unclear what impact these changes have on bone mineral density (BMD). We prospectively analayzed levels of osteocalcin, a marker of bone formation secreted by osteoblasts, and serum N-telopeptide of type I collagen (NTX), a marker of bone resorption, as well as other minerals involved in bone metabolism  in 19 patients with either CML or GIST We correlated these results with changes in bone mineral density as measured by serial dual energy X-ray absorptiometry (DEXA) scans over a two year period. Osteocalcin levels were low in 95% of patients and 37% had no measurable amount. Levels of NTX were less consistent. Nine patients (47%) had a decrease in BMD, four patients (2%) had an increase in  BMD, and six patients (32%) had no change. There was no correlation between metabolic markers and change in BMD. We suggest that ongoing management of patients who take imatinib should include monitoring of bone health on a long term basis.

 

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[134]

TÍTULO / TITLE:  - Designing novel therapies against sarcomas in the era of personalized medicine and economic crisis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Curr Pharm Des. 2013 Feb 4.

AUTORES / AUTHORS:  - Manara MC; Garofalo C; Ferrari S; Belfiore A; Scotlandi K

INSTITUCIÓN / INSTITUTION:  - Development of Biomolecular therapies, Experimental Oncology Lab and 2Clinical Oncology, Via Di Barbiano 1/10, 40136 Rizzoli Institute, Bologna, Italy. katia.scotlandi@ior.it.

RESUMEN / SUMMARY:  - Drug “repurposing” is the process of finding new therapeutic indications for existing drugs, and can be considered as a more efficient and realistic strategy  for the design of therapies against rare diseases than the current efforts to develop targeted-drugs. In this review, we explore the difficulties related to the identification and development of tailored therapies for individual patients  with sarcomas, which are relatively rare diseases characterized by an extreme genetic and histologic variability. Overall, sarcomas comprise about 1% of all adult tumors and 10% of pediatric cancers. They are conventionally divided in bone and soft-tissue sarcomas, considering their site of origin. However, each group is highly heterogeneous and recent global characterization of their genetic alterations has clearly identified the existence of peculiarities that render these group of tumors even more “orphan” for pharmaceutical companies to develop  and market specific- targeted drugs. The present review highlights key examples of molecular targets identification in bone sarcomas, reexamining the history of  insulin-like growth factor receptor (IGF-IR) and its role in physiology and in cancer as well as developments regarding phase I to II clinical trials of agents  directed against this receptor. The IGF system is quite complex, with many players in the field. Insulin receptor function in cancer cells has certainly been underestimated, but also little attention was paid to the type of ligands that are mainly involved in each tumor type. Strategies considering the system in its complex are encouraged and, in this context, drugs aimed at reducing circulating insulin levels, such as metformin, should receive attention as potential anti-cancer agents.

 

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[135]

TÍTULO / TITLE:  - Variable ALK protein and ALK gene staining in inflammatory myofibroblastic tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Dev Pathol. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 2350/13-03-1311-LET.1

AUTORES / AUTHORS:  - Katzman PJ

INSTITUCIÓN / INSTITUTION:  - University of Rochester Medical Center, Department of Pathology and Laboratory Medicine.

RESUMEN / SUMMARY:  - Abstract Not applicable.

 

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[136]

TÍTULO / TITLE:  - Interactomic approach for evaluating nucleophosmin-binding proteins as biomarkers for Ewing’s sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Electrophoresis. 2013 Mar 11. doi: 10.1002/elps.201200661.

            ●● Enlace al texto completo (gratuito o de pago) 1002/elps.201200661

AUTORES / AUTHORS:  - Haga A; Ogawara Y; Kubota D; Kitabayashi I; Murakami Y; Kondo T

INSTITUCIÓN / INSTITUTION:  - Division of Pharmacoproteomics, National Cancer Center Research Institute, 5-1-1  Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Faculty of Industrial Science and Technology, Department of Biological Science and Technology, Tokyo University of  Science, 2641 Yamazaki, Noda-shi, Chiba, 278-8510, Japan.

RESUMEN / SUMMARY:  - Nucleophosmin (NPM) is a novel prognostic biomarker for Ewing’s sarcoma. To evaluate the prognostic utility of NPM, we conducted an interactomic approach to  characterize the NPM protein complex in Ewing’s sarcoma cells. A gene suppression assay revealed that NPM promoted cell proliferation and the invasive properties of Ewing’s sarcoma cells. FLAG-tag-based affinity purification coupled with liquid chromatography-tandem mass spectrometry identified 106 proteins in the NPM protein complex. The functional classification suggested that the NPM complex participates in critical biological events, including ribosome biogenesis, regulation of transcription and translation, and protein folding, that are mediated by these proteins. In addition to JAK1, a candidate prognostic biomarker for Ewing’s sarcoma, the NPM complex, includes 11 proteins known as prognostic biomarkers for other malignancies. Meta-analysis of gene expression profiles of 32 patients with Ewing’s sarcoma revealed that 6 of 106 were significantly and independently associated with survival period. These observations suggest a functional role as well as prognostic value of these NPM complex proteins in Ewing’s sarcoma. Further, our study suggests the potential applications of interactomics in conjunction with meta-analysis for biomarker discovery.

 

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[137]

TÍTULO / TITLE:  - RANKL/OPG Ratio and DKK-1 Expression in Primary Osteoblastic Cultures from Osteoarthritic and Osteoporotic Subjects.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Rheumatol. 2013 Mar 1.

            ●● Enlace al texto completo (gratuito o de pago) 3899/jrheum.120845

AUTORES / AUTHORS:  - Corrado A; Neve A; Macchiarola A; Gaudio A; Marucci A; Cantatore FP

INSTITUCIÓN / INSTITUTION:  - From the Rheumatology Clinic, Department of Medical and Occupational Sciences, University of Foggia; Orthopedic Surgery Unit, Ospedali Riuniti di Foggia, Foggia, Italy.

RESUMEN / SUMMARY:  - OBJECTIVE: To evaluate the expression of Dickkopf-1 protein factor (DKK-1), DKK-2, and beta-catenin, components of the Wnt pathway, in human osteoarthritic (OA) and osteoporotic (OP) osteoblasts and to correlate it to cell metabolic activity, proliferation, and receptor activator of nuclear factor-kappaB ligand/osteoprotegerin (RANKL/OPG) expression. METHODS: Primary human osteoblast  cultures were obtained from healthy, OA, and OP donors. In each cell population we evaluated DKK-1, DKK-2, nonphosphorylated beta-catenin and RANKL/OPG expression, osteocalcin and alkaline phosphatase (ALP) synthesis, and cell proliferation, both in basal condition and after vitamin D3 stimulation. RESULTS: DKK-1 and DKK-2 showed opposite patterns of expression in OA and OP osteoblasts.  The RANKL/OPG ratio was significantly higher in the OP group because of a greater expression of RANKL, whereas it was significantly lower in the OA group because of a higher expression of OPG. Treatment with vitamin D3 increased the RANKL/OPG  ratio and DKK-2 expression and reduced DKK-1 expression in each cell population,  but did not affect beta-catenin levels. Both osteocalcin and ALP production and cell proliferation were enhanced in OA cells and reduced in the OP ones. CONCLUSION: These data confirm that OA and OP are characterized by opposite bone  changes, consisting of reduced bone remodeling processes with increased osteoblast activity in OA, and enhanced bone resorptive activity with reduction of osteoblast metabolism in OP, and suggest that the Wnt pathway is involved in the pathogenesis of both diseases.

 

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[138]

TÍTULO / TITLE:  - Induction of apoptosis in osteosarcoma s180 cells by polysaccharide from dictyophora indusiata.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cell Biochem Funct. 2013 Feb 10. doi: 10.1002/cbf.2961.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cbf.2961

AUTORES / AUTHORS:  - Zhong B; Ma Y; Fu D; Zhang C

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Shanghai 6th People’s Hospital, Shanghai Jiao  Tong University, Shanghai, China.

RESUMEN / SUMMARY:  - Polysaccharides have shown great importance in cancer therapy. The current study  showed that a polysaccharide from Dictyophora indusiata (PDI) also possessed anti-cancer properties. Methyl thiazolyl tetrazolium assay revealed a dose-dependent reduction of osteosarcoma S180 growth in response to PDI treatment. Apoptosis was observed following treatments with PDI, as reflected by  the appearance of the subdiploid fraction and DNA fragmentations. We then investigated effects of PDI on expression of apoptosis-associated genes and the results revealed an increase of expression of bcl-2 and decreases of cdk4 and p53 protein levels. Finally, PDI treatment significantly increased the activation of  caspase-3, a key executioner of apoptosis. These findings indicate that PDI may act as a chemopreventive and/or chemotherapeutic agent in osteosarcoma cells by reducing cell viability and inducing apoptosis. Copyright © 2013 John Wiley & Sons, Ltd.

 

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[139]

TÍTULO / TITLE:  - Racial differences in fibroid prevalence and ultrasound findings in asymptomatic  young women (18-30 years old): a pilot study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Fertil Steril. 2013 Mar 15. pii: S0015-0282(13)00274-4. doi: 10.1016/j.fertnstert.2013.02.017.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.fertnstert.2013.02.017

AUTORES / AUTHORS:  - Marsh EE; Ekpo GE; Cardozo ER; Brocks M; Dune T; Cohen LS

INSTITUCIÓN / INSTITUTION:  - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics  and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address: erica-marsh@northwestern.edu.

RESUMEN / SUMMARY:  - OBJECTIVE: 1) To determine the prevalence of fibroids in asymptomatic young black and white women (ages 18-30 y); 2) to determine other differences in uterine and  adnexal anatomy; and 3) to obtain preliminary data for sample size calculations.  DESIGN: Pilot cross-sectional study. SETTING: Academic medical center. PATIENT(S): One hundred one nonparous black and white women, ages 18-30 years, with no known diagnosis of fibroids or clinically suggestive symptoms. INTERVENTION(S): A transvaginal ultrasound was performed in the follicular phase  in all subjects. MAIN OUTCOME MEASURE(S): 1) Presence of fibroids; 2) endometrial thickness; 3) ovarian findings. RESULT(S): Of the 101 participants (mean age 24.5 +/- 3.5 y), 43% self-identified as black and 57% as white. The prevalence of ultrasound-diagnosed fibroids was 15% overall (26% in black women and 7% in white women). The mean fibroid size was 2.3 +/- 2.1 cm. There was a significant difference in endometrial thickness between races, even after adjusting for contraception use and fibroid presence. CONCLUSION(S): Racial differences in fibroid prevalence exist even before women become symptomatic. Findings of thicker endometrium in black women could have clinical implications and warrants  further investigation.

 

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[140]

TÍTULO / TITLE:  - Accuracy of segmental multi-frequency bioelectrical impedance analysis for assessing whole-body and appendicular fat mass and lean soft tissue mass in frail women aged 75 years and older.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Clin Nutr. 2013 Apr;67(4):395-400. doi: 10.1038/ejcn.2013.9. Epub 2013 Feb  6.

            ●● Enlace al texto completo (gratuito o de pago) 1038/ejcn.2013.9

AUTORES / AUTHORS:  - Kim M; Kim H

INSTITUCIÓN / INSTITUTION:  - Research Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

RESUMEN / SUMMARY:  - BACKGROUND/OBJECTIVE: We aimed to examine the accuracy of segmental multi-frequency bioelectrical impedance analysis (SMF-BIA) for the assessment of  whole-body and appendicular fat mass (FM) and lean soft tissue mass (LM) in frail older women, using dual-energy X-ray absorptiometry (DXA) as a reference method.  SUBJECTS/METHODS: All 129 community-dwelling Japanese frail older women with a mean age of 80.9 years (range, 75-89 years) from the Frailty Intervention Trial were recruited. The agreements between SMF-BIA and DXA for whole-body and appendicular body composition were assessed using simple linear regression and Bland-Altman analysis. RESULTS: High coefficients of determination (R(2)) for whole-body FM (R(2)=0.94, s.e. of estimate (SEE)=1.2 kg), whole-body LM (R(2)=0.85, SEE=1.4 kg), and appendicular FM (R(2)=0.82, SEE=1.1 kg) were observed between SMF-BIA and DXA. The R(2) coefficient for appendicular LM was moderate (R(2)=0.76, SEE=0.8 kg). Bland-Altman plots demonstrated that there was  systematic (constant) bias (that is, DXA minus SMF-BIA) with overestimation of whole-body FM (bias=-1.2 kg, 95% confidence interval (CI)=-1.5 to -0.1) and underestimation of whole-body LM (bias=2.1 kg, 95% CI=1.8-2.3) by SMF-BIA. Similar, the appendicular measurements also demonstrated systematic bias with overestimation of appendicular FM (bias=-0.3 kg, 95% CI=-0.5 to -0.1) and underestimation of whole-body LM (bias=1.5 kg, 95% CI=1.4-1.7) by SMF-BIA. In addition, the individual level accuracy demonstrated a non-proportional bias for  whole-body LM (r=0.08, P=0.338) and appendicular FM (r=0.07, P=0.413). CONCLUSIONS: SMF-BIA had acceptable accuracy for the estimation of whole-body and appendicular FM and LM in frail older women, although SMF-BIA underestimated LM and overestimated FM relative to DXA.

 

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[141]

TÍTULO / TITLE:  - Endometrial stromal sarcoma: clinicopathological and immunophenotypic study of 16 cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Gynecol Obstet. 2013 Feb 23.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00404-013-2766-3

AUTORES / AUTHORS:  - Iwasaki SI; Sudo T; Miwa M; Ukita M; Morimoto A; Tamada M; Ueno S; Wakahashi S; Yamaguchi S; Fujiwara K; Sakuma Y; Mikami Y; Nishimura R

INSTITUCIÓN / INSTITUTION:  - Department of Gynecologic Oncology, Hyogo Cancer Center, 13-70 Kita-Oji, Akashi,  6738558, Japan.

RESUMEN / SUMMARY:  - PURPOSE: Endometrial stromal sarcomas (ESSs) are rare tumors and are divided into two groups: low-grade endometrial stromal sarcoma (ESS-LG) and undifferentiated endometrial sarcoma (UES). The purpose of this study was to compare the clinicopathological features and immunophenotypes of ESS-LG and UES. METHODS: The authors evaluated 16 patients diagnosed with ESS at the Hyogo Cancer Center, reviewed their files and data, and performed an immunohistochemical study for oncogenic proteins (EGFR, PDGFR-alpha, and PDGFR-beta) and cell cycle regulators  (cyclin D1, cyclin E, p16(INK4a), p21(cip1), p27(kip1), and p53) to compare ESS-LG and UES using the World Health Organization (WHO) classification. RESULTS: Four cases (25 %) were classified as ESS-LGs and 12 (75 %) as UES. Patients with  UES had a significantly worse overall survival than did those with ESS-LG (p = 0.0445). Although no ESS-LGs showed expression of p16(INK4a), 10 of 12 (83 %) UESs showed expression of p16(INK4a). UESs showed a trend toward higher expression of cyclin D1, p21(cip1), and p53 compared with ESS-LGs. CONCLUSIONS: Our data emphasize the clinical importance of the WHO classification of ESS. It is of utmost importance to establish a proper classification to increase the consistency of data that may be useful for improving clinical and therapeutic management of patients with ESS.

 

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[142]

TÍTULO / TITLE:  - Microarray expression profile of long noncoding RNAs in human osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochem Biophys Res Commun. 2013 Apr 5;433(2):200-6. doi: 10.1016/j.bbrc.2013.02.083. Epub 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bbrc.2013.02.083

AUTORES / AUTHORS:  - Li JP; Liu LH; Li J; Chen Y; Jiang XW; Ouyang YR; Liu YQ; Zhong H; Li H; Xiao T

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410010, PR China.

RESUMEN / SUMMARY:  - Long noncoding RNAs (lncRNAs) are pervasively transcribed and have a critical role in genome regulation. Alterations in the expression of several lncRNAs have  been observed in some types of cancers; however, the contributions of lncRNAs to  osteosarcoma remain unknown. Here, we describe the expression profile of lncRNAs  in osteosarcomas compared with paired adjacent noncancerous tissue using microarray analysis. In our study, 25,733 lncRNAs were expressed in osteosarcoma; 403 lncRNAs were consistently over-regulated and 798 lncRNAs were consistently under-regulated in all samples analyzed (2.0-fold, p<0.05). Quantitative real-time polymerase chain reaction (PCR) was used to validate six over-regulated and four under-regulated lncRNAs. Bioinformatic analysis (gene ontology analysis, pathway analysis and network analysis) was used for further research. Pathway analysis indicated that 32 pathways corresponded to under-regulated transcripts and that 34 pathways corresponded to over-regulated transcripts (p-value cut-off  is 0.05). Our results are the first to reveal differentially expressed lncRNAs in osteosarcoma and suggest that lncRNAs may be novel candidate biomarkers for the diagnosis of osteosarcoma and potential targets for therapy.

 

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[143]

TÍTULO / TITLE:  - Ectopic production of human chorionic gonadotropin by synovial sarcoma of the hip.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Obstet Gynecol. 2013 Feb;121(2 Pt 2 Suppl 1):468-71. doi: 10.1097/AOG.0b013e31826d3121.

AUTORES / AUTHORS:  - Stevens EE; Aquino J; Barrow N; Lee YC

INSTITUCIÓN / INSTITUTION:  - SUNY Downstate Medical Center, Department of Obstetrics & Gynecology-Division of  Gynecologic Oncology, Brooklyn, New York 11203, USA. erin.stevens@downstate.edu

RESUMEN / SUMMARY:  - BACKGROUND: Human chorionic gonadotropin (hCG) is a marker of pregnancy and a tumor marker for some gynecologic malignancies, including germ cell tumors and gestational trophoblastic neoplasia. Rarely, hCG is secreted by nongynecologic tumors, confounding the diagnosis. CASE: A 45-year-old woman was evaluated for a  persistently elevated beta-hCG. Diagnosis of her primary malignancy, synovial sarcoma of the hip, was delayed as more common etiologies were considered, including ectopic pregnancy and gestational trophoblastic neoplasm. The workup eventually led to the diagnosis using imaging studies but ultimately resulted in  a 3-month delay and unnecessary medical and surgical treatments. CONCLUSION: This case highlights the importance of nongynecologic malignancies when evaluating patients with a persistent beta-hCG.

 

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[144]

TÍTULO / TITLE:  - The expression and functionality of stromal caveolin 1 in human adenomyosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Reprod. 2013 Feb 26.

            ●● Enlace al texto completo (gratuito o de pago) 1093/humrep/det042

AUTORES / AUTHORS:  - Zhao L; Zhou S; Zou L; Zhao X

INSTITUCIÓN / INSTITUTION:  - Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, 610041 Chengdu, P. R. China.

RESUMEN / SUMMARY:  - STUDY QUESTION: What is the expression pattern and functionality of caveolin 1 (CAV1) in the endometrium of patients with adenomyosis? SUMMARY ANSWER: The stromal CAV1 expression is down-regulated that leads to the release of a variety  of molecules that either enhance the metastatic capacity of endometrial cells or  contribute to adenomyosis-associated dysmenorrhea. WHAT IS KNOWN ALREADY: Adenomyosis is characterized by invasion of endometrium into the uterine myometrium. CAV1 has been linked to tumor progression and clinical outcome in a variety of human malignancies; however, its role in adenomyosis development and adenomyosis-associated dysmenorrhea is still poorly recognized. STUDY DESIGN, SIZE, DURATION: We retrospectively analyzed the expression levels of CAV1 and RANTES protein using immunohistochemistry in 65 patients who were pathologically  diagnosed with adenomyosis and 12 control women without related pathology, who were subjected to surgery between 2009 and 2010. Endometrial tissues from six additional normal females without related pathology were collected from 2011 to 2012; these tissues were subjected to subsequent primary cell culture experiments. PARTICIPANTS/MATERIALS, SETTING, METHODS: The expression of CAV1 and RANTES was examined by immunohistochemistry in ectopic endometrium and paired eutopic endometrium of 65 adenomyosis patients and 12 control patients. Primary endometrial stromal cells (ESCs) and endometrial epithelial cells (EECs) were isolated from 6 additional control females without related pathology. The expression of CAV1 in ESCs was either (i) inhibited by siRNA transfection and methyl-beta-cyclodextrin (MbetaCD) treatment or (ii) increased by pcDNA3.1/CAV1 transfection. The impact of each treatment on the proliferation, migration and invasion of both ESCs and EECs was evaluated by methylthiazolydiphenyl-tetrazolium assay, colony formation assay, Transwell migration and invasion assay. Furthermore, ESC treatment with MbetaCD and siCAV1  was assessed for the effect on the expression of a panel of inflammatory cytokines. The levels of two pain mediators, nitric oxide (NO) and prostaglandin  E2 (PGE2), were assessed in CAV-1-depleted and control ESCs, whereas immunoblotting was performed to characterize signaling pathways downstream to loss of stromal CAV1 in endometrium. The correlation between dysmenorrhea severity and stromal CAV1 and RANTES expression was further examined using ‘Pearson’s’ correlation analysis. MAIN RESULTS: Stromal CAV1 expression in ectopic endometrium of adenomyosis patients was significantly lower than that of  paired eutopic endometrium or normal controls as analyzed by immunohistochemistry (P < 0.001). Although no significant difference was observed in the proliferation of CAV1-depleted ESCs when compared with control group, EECs cultured with conditioned media from CAV1-depleted ESCs demonstrated a significantly elevated proliferation rate when compared with those treated with control ESC-conditioned  media. Moreover, both CAV1-depleted ESCs and EECs cultured with conditioned media from CAV1-depleted ESCs showed enhanced migration and invasion capacity when compared with control group (P < 0.05). In contrast, incubation with conditioned  media of ESCs with enforced CAV1 expression led to decreased proliferation capacity of EECs. Furthermore, the expression of RANTES in ESCs treated with MbetaCD and siCAV1 was significantly increased. Stromal RANTES expression in the  ectopic endometrium of adenomyosis patients was significantly higher than that of paired eutopic endometrium or normal controls as analyzed by immunohistochemistry (P = 0.0026). Stromal CAV1 expression in eutopic endometrium was significantly lower in women with more severe dysmenorrhea (P < 0.05) and was negatively correlated with dysmenorrhea severity in adenomyosis patients (r(2) = 0.1549; P = 0.012, ‘Pearson’s’ chi(2) test), whereas stromal RANTES expression in eutopic endometrium was significantly higher in women with more severe dysmenorrhea (P <  0.05) and was positively correlated with dysmenorrhea severity in adenomyosis patients (r(2) = 0.1646; P = 0.0094, ‘Pearson’s’ chi(2) test). Silencing of CAV1  in ESCs led to increased release of NO and PGE2 when compared with control and was associated with enhanced activity of ERK-FAK signaling pathway. LIMITATIONS,  REASONS FOR CAUTION: This study assessed the functional role of stromal CAV1 and  RANTES in a small number of human adenomyosis samples by immunohistochemistry and in primary human ESCs by functional studies. In future investigations, a larger sample size should be adopted and the functional role of stromal CAV1 should be further characterized in animal models. WIDER IMPLICATIONS OF THE FINDINGS: Loss  of stromal CAV1 expression may play a critical role in the pathogenesis of adenomyosis and is correlated with adenomyosis-related dysmenorrhea. STUDY FUNDING: National Basic Research Program of China and Ph.D. Programs Foundation of Ministry of Education of China. COMPETING INTEREST: None.

 

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[145]

TÍTULO / TITLE:  - Curcumin Induces Cross-Regulation Between Autophagy and Apoptosis in Uterine Leiomyosarcoma Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Gynecol Cancer. 2013 Mar 23.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IGC.0b013e31828c9581

AUTORES / AUTHORS:  - Li B; Takeda T; Tsuiji K; Wong TF; Tadakawa M; Kondo A; Nagase S; Yaegashi N

INSTITUCIÓN / INSTITUTION:  - *Division of Women’s Health, Research Institute of Traditional Asian Medicine, Kinki University School of Medicine, Osaka; and daggerDepartment of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.

RESUMEN / SUMMARY:  - OBJECTIVE: Uterine leiomyosarcoma (LMS) has an unfavorable response to standard chemotherapy. A natural occurring compound, curcumin, has been shown to have inhibitory effects on cancers. We previously demonstrated that curcumin reduced uterine LMS cell proliferation by targeting the AKT-mTOR pathway and activating apoptosis. To further explore the anticancer effect of curcumin, we investigated  the efficacy of curcumin on autophagy in LMS cells. METHODS: Cell proliferation in human uterine LMS cell lines, SKN and SK-UT-1, was assessed after exposure to  rapamycin or curcumin. Autophagy was detected by Western blotting for light chain 3 and sequestosome 1 (SQSTM1/p62) expression. Apoptosis was confirmed by Western  blotting for cleaved poly (ADP-ribose) polymerase (PARP). RESULTS: Both rapamycin and curcumin potently inhibited SKN and SK-UT-1 cell proliferation in a dose-dependent manner. Curcumin induced autophagy and apoptosis in SKN and SK-UT-1 cells, whereas rapamycin, a specific mTOR inhibitor, did not. Curcumin increased extracellular signal-regulated kinase ½ activity in both SKN and SK-UT-1 cells, whereas PD98059, an MEK1 inhibitor, inhibited both the extracellular signal-regulated kinase ½ pathway and curcumin-induced autophagy. CONCLUSIONS: These experimental findings suggest that curcumin is a potent inhibitor of cell proliferation in uterine LMS and provide new insights about ongoing signaling events leading to the possible development of a new therapeutic agent.

 

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[146]

TÍTULO / TITLE:  - A Composite Neoplastic Lesion of the Vulva With Mixed Features of Fibroadenoma and Hidradenoma Papilliferum Combined With Pseudoangiomatous Stromal Hyperplasia  Containing Multinucleated Giant Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Dermatopathol. 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1097/DAD.0b013e31828742e4

AUTORES / AUTHORS:  - Konstantinova AM; Kacerovska D; Michal M; Kazakov DV

INSTITUCIÓN / INSTITUTION:  - *Department of Pathology, Clinical Oncological Scientific and Practical Centre for Specialized Medical Care, Saint Petersburg, Russia; daggerDepartment of Pathology Medical Faculty, Saint Petersburg State University, Russia; double daggerSikl’s Department of Pathology, Faculty of Medicine in Pilsen, Charles University in Prague, Czech Republic; and section signDepartment of Pathology, Medical Faculty, Bioptical Laboratory, Pilsen, Czech Republic.

RESUMEN / SUMMARY:  - : Anogenital mammary-like glands (AGMLG) are nowadays considered a normal component of the anogenital area. Lesions affecting AGMLG are similar to those seen in breast. We present a case of a complex neoplastic lesion of the AGMLG with mixed features of fibroadenoma and hidradenoma papilliferum combined with pseudoangiomatous stromal hyperplasia. Multinucleated cells were detected in the  pseudoangiomatous stromal hyperplasia areas as seen in some patients with neurofibromatosis type 1. The neoplasm is similar to rare mammary composite neoplasms that feature simultaneously patterns of a fibroepithelial neoplasms and intraductal papilloma.

 

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[147]

TÍTULO / TITLE:  - Kaposi sarcoma trends in Uganda and Zimbabwe: A sustained decline in incidence?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Cancer. 2013 Feb 22. doi: 10.1002/ijc.28125.

            ●● Enlace al texto completo (gratuito o de pago) 1002/ijc.28125

AUTORES / AUTHORS:  - Chaabna K; Bray F; Wabinga HR; Chokunonga E; Borok M; Vanhems P; Forman D; Soerjomataram I

INSTITUCIÓN / INSTITUTION:  - Section of Cancer Information, International Agency for Research on Cancer, Lyon, France.

RESUMEN / SUMMARY:  - Trends in Kaposi sarcoma (KS) incidence over four decades were described for Zimbabwe and Uganda. KS data were retrieved from the population-based cancer registries of Bulawayo (1963-1971) and Harare (1990-2005), Zimbabwe and Kyadondo, Uganda (1960-1971 and 1991-2007). Joinpoint regression models were used to analyze time trends of KS incidence. Trends were compared to HIV/AIDS trends and  were also described as rates versus birth cohort by age. In both countries, an increased incidence of KS accompanied the emergence of the HIV/AIDS epidemic (p-value < 0.0001). In Zimbabwe, KS incidence (both sexes, all ages) changed in parallel to that of HIV/AIDS prevalence, whereas in Uganda, despite an observed decrease in HIV/AIDS prevalence since 1992, we observed a decrease in KS incidence in men younger than 50 years (Annual Percent Change, APC after 1991 = -4.5 [-5.6; -3.4], p-value < 0.05) but not in men aged >50 years (APC after 1991  = 1.0 [-2.8; 5.0]) nor in women (APC = 1.0 [-0.6; 2.6]). In both populations, a period effect at older ages was observed, with initial increases in incidence in  men followed subsequently by a downturn in rates of the same magnitude. The uniformly declining rates in younger men (aged less than 30 years) suggested that a recent cohort effect was also in operation with a reduced risk in generations born after the mid-1950s in Uganda and in the mid-1960s in Zimbabwe. The combined introduction of antiretroviral therapy and effective prevention programmes against HIV/AIDS appeared to be the key contributors to the KS decline observed in both Uganda and Zimbabwe.

 

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[148]

TÍTULO / TITLE:  - Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bone. 2013 Mar 5. pii: S8756-3282(13)00093-8. doi: 10.1016/j.bone.2013.02.021.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bone.2013.02.021

AUTORES / AUTHORS:  - Liu L; Xu Y; Reiter RJ

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, East Hospital, Tongji University School of Medicine,  Shanghai, China; Trauma Center, East Hospital, Tongji University School of Medicine, Shanghai, China; Institute of Trauma, East Hospital, Tongji University  School of Medicine, Shanghai, China. Electronic address: li_feng_liu@hotmail.com.

RESUMEN / SUMMARY:  - It seems established that the onset of osteosarcoma and the reduction in melatonin production run in parallel; this suggests that the decline in the cancer-inhibiting agent, melatonin, may contribute to the occurrence of osteosarcoma and that melatonin supplementation may have promise for preventing the development and progression of this condition. There is, however, no direct evidence regarding an antiproliferative effect of melatonin in osteosarcoma cells. In the current study, we examined whether melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. MTT staining showed that at  4mM-10mM concentrations, melatonin significantly reduced the MG-63 cell proliferation in a dose-dependent and time-dependent manner. Flow cytometry documented that 4mM melatonin significantly increased the fraction of cells in the G0/G1 phase of the cell cycle, while simultaneously reducing the proportion in the S and G2/M phases. Western blot and real-time PCR analyses further confirmed that melatonin’s inhibitory effect was possibly because of downregulation of cyclin D1 and CDK4, related to the G1 phase, and of cyclin B1 and CDK1, related to the G2/M phase. There was no downregulation of cyclin E, CDK2, and cyclin A, which are related to G1/S transition and S phase. These findings provide evidence that melatonin may significantly inhibit human osteosarcoma cell proliferation in a dose-dependent and time-dependent manner and this inhibition involves the downregulation of cyclin D1, CDK4, cyclin B1 and CDK1.

 

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[149]

TÍTULO / TITLE:  - Radiofrequency ablation in the treatment of osteoid osteoma: results and complications.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Radiol. 2013 Feb 14.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00247-013-2636-y

AUTORES / AUTHORS:  - Earhart J; Wellman D; Donaldson J; Chesterton J; King E; Janicki JA

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.

RESUMEN / SUMMARY:  - BACKGROUND: Percutaneous radiofrequency ablation (RFA) for treatment of osteoid osteoma is effective and avoids the potential complications of open surgical resection. This study evaluates the efficacy of RFA at a single tertiary-care pediatric hospital and highlights an important complication. MATERIALS AND METHODS: The medical records of 21 cases of RFA in 21 children between 2004 and 2010 were reviewed retrospectively for demographic data, lesion site, access point and technique for ablation, clinical outcome and complications. RESULTS: Clinical follow-up was available for 17/21 children (81%) at an average of 17.0 months (range 0.5-86.1 months). No persistence or recurrence of pre-procedural pain was noted. Two children (9.5%) had a complication, including a burn to the local skin and muscle requiring local wound care, and a late subtrochanteric femur fracture treated successfully with open reduction internal fixation. CONCLUSION: RFA is a safe and effective alternative to surgical resection of the  osteoid osteoma nidus. When accessing the proximal femur, the risk of late post-procedural fracture must be considered and discussed with the family. An understanding of biomechanical principles in the proximal femur might provide an  effective strategy for limiting this risk.

 

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[150]

TÍTULO / TITLE:  - Stages I to II WHO 2003-defined low-grade endometrial stromal sarcoma: how much primary therapy is needed and how little is enough?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Gynecol Cancer. 2013 Mar;23(3):488-93. doi: 10.1097/IGC.0b013e318247aa14.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IGC.0b013e318247aa14

AUTORES / AUTHORS:  - Feng W; Hua K; Malpica A; Zhou X; Baak JP

INSTITUCIÓN / INSTITUTION:  - Department of Gynaecology, Hospital of Fudan University, Shanghai, China.

RESUMEN / SUMMARY:  - OBJECTIVE: Before 2003, invasive endometrial stromal sarcomas (ESS) were classified into 2 categories, low-grade and high-grade ESS, according to the mitotic index. In 2003, the World Health Organization changed the definition and  the diagnostic criteria. Before 2003, 20% to 35% low-grade ESS recurred, but WHO  2003-defined low-grade ESS has 10 years’ recurrence rates of less than 10%. With  so few recurrences, the balance between treatment guaranteeing cure and overtreatment (“not too little” or “too much”) becomes increasingly important. However, primary treatment practices range from limited surgery only to extensive surgery combined with adjuvant chemotherapy and radiotherapy. We focused on the primary treatment of early-stage WHO 2003-defined low-grade ESS. METHODS: We evaluated the effect of different therapeutic strategies in 57 patients with International Federation of Gynecology and Obstetrics 2009 stages I to II expert-reviewed WHO 2003-defined low-grade ESS treated at a single institution between 1992 and 2007. RESULTS: The patients’ median age was 43 years (range, 19-63 years). After 68 months’ median follow-up (range, 17-140 months), recurrence and mortality rates were 9% and 2%, respectively. The patients with WHO 2003-defined low-grade ESS with ovary-preserving primary surgery had a much higher recurrence rate (75%) than those without (2%; P < 0.0001). Lymphadenectomy, radical abdominal hysterectomy, and omentectomy did not influence survival. Ten patients refused chemotherapy. With univariate analysis,  multiple-agent chemotherapy improved the prognosis (P = 0.02) With multivariate analysis, only ovary preservation-or-not surgery had independent prognostic value. CONCLUSIONS: In International Federation of Gynecology and Obstetrics 2009 stage I to stage II WHO 2003-defined low-grade ESS, total abdominal hysterectomy  with bilateral salpingo-oophorectomy is sufficient surgery, but ovary-preserving  primary surgery increases the risk of recurrence. More extensive surgical procedures than total abdominal hysterectomy with bilateral salpingo-oophorectomy do not improve prognosis in early-stage WHO 2003-defined low-grade ESS. Chemotherapy may improve progression-free survival in early-stage low-grade ESS,  but a large sample size is needed to confirm this.

 

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[151]

TÍTULO / TITLE:  - Morphological changes induced by advanced glycation endproducts in osteoblastic cells: Effects of co-incubation with alendronate.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Histochem. 2013 Mar 1. pii: S0065-1281(13)00018-4. doi: 10.1016/j.acthis.2013.01.004.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.acthis.2013.01.004

AUTORES / AUTHORS:  - Gangoiti MV; Anbinder PS; Cortizo AM; McCarthy AD

INSTITUCIÓN / INSTITUTION:  - LIOMM, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 47 y 115, CP (1900) La Plata, Argentina. Electronic address: mvgangoiti@biol.unlp.edu.ar.

RESUMEN / SUMMARY:  - Advanced glycation endproducts (AGEs) accumulate with age in various tissues, and are further increased in patients with Diabetes mellitus, in which they are believed to contribute to the development and progression of chronic complications that include a decrease in bone quality. Bisphosphonates are anti-osteoporotic drugs that have been used for the treatment of patients with diabetic bone alterations, although with contradictory results. In the present study, we have evaluated the in vitro alterations on osteoblastic morphology by environmental scanning electron microscopy, in actin cytoskeleton and apoptosis induced by AGEs, as well as the modulation of these effects by alendronate (an N-containing bisphosphonate). Our present results provide evidence for disruption induced by AGEs of the osteoblastic actin cytoskeleton (geodesic domes) and significant alterations in cell morphology with a decrease in cell-substratum interactions leading to an increase in apoptosis of osteoblasts and a decrease in osteoblastic proliferation. High concentrations of alendronate (10-5M, such as could be expected in an osteoclastic lacuna) further increase osteoblastic morphological and cytoskeletal alterations. However, low doses of alendronate (10-8M, compatible with extracellular fluid levels to which an osteoblast could be exposed for most of its life cycle) do not affect cell morphology, and in addition are able to prevent AGEs-induced alterations and consequently apoptosis  of osteoblasts.

 

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[152]

TÍTULO / TITLE:  - GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Jan 31. pii: S0046-8177(12)00425-X. doi: 10.1016/j.humpath.2012.11.003.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.11.003

AUTORES / AUTHORS:  - Cimino-Mathews A; Subhawong AP; Illei PB; Sharma R; Halushka MK; Vang R; Fetting JH; Park BH; Argani P

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231. Electronic address: acimino@jhmi.edu.

RESUMEN / SUMMARY:  - GATA3 plays an integral role in breast luminal cell differentiation and is implicated in breast cancer progression. GATA3 immunohistochemistry is a useful marker of breast cancer; however, its use in specific subtypes is unclear. Here,  we evaluate GATA3 expression in 86 invasive ductal carcinomas including triple-negative, Her-2, and luminal subtypes, in addition to 13 metaplastic carcinomas and in 34 fibroepithelial neoplasms. In addition, we report GATA3 expression in matched primary and metastatic breast carcinomas in 30 patients with known estrogen receptor (ER), progesterone receptor (PR), and Her-2 status,  including 5 with ER and/or PR loss from primary to metastasis. Tissue microarrays containing 5 to 10 cores per tumor were stained for GATA3, scored as follows: 0 (0-5%), 1+ (6%-25%), 2+ (26%-50%), 3+ (51%-75%), and 4+ (>75%). GATA3 labeling was seen in 67% (66/99) of primary ductal carcinomas including 43% of triple-negative and 54% of metaplastic carcinomas. In contrast, stromal GATA3 labeling was seen in only 1 fibroepithelial neoplasm. GATA3 labeling was seen in  90% (27/30) of primary breast carcinomas in the paired cohort, including 67% of triple-negative carcinomas. GATA3 labeling was overwhelmingly maintained in paired metastases. Notably, GATA3 was maintained in all “luminal loss” metastases, which showed ER and/or PR loss. In conclusion, GATA3 expression is maintained between matched primary and metastatic carcinomas including ER-negative cases. GATA3 can be particularly useful as a marker for metastatic breast carcinoma, especially triple-negative and metaplastic carcinomas, which lack specific markers of mammary origin. Finally, GATA3 labeling may help distinguish metaplastic carcinoma from malignant phyllodes tumors.

 

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[153]

TÍTULO / TITLE:  - GNAS mutational analysis in differentiating fibrous dysplasia and ossifying fibroma of the jaw.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mod Pathol. 2013 Mar 15. doi: 10.1038/modpathol.2013.31.

            ●● Enlace al texto completo (gratuito o de pago) 1038/modpathol.2013.31

AUTORES / AUTHORS:  - Shi RR; Li XF; Zhang R; Chen Y; Li TJ

INSTITUCIÓN / INSTITUTION:  - Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, China.

RESUMEN / SUMMARY:  - Differential diagnosis of fibrous dysplasia and ossifying fibroma may often pose  problems for pathologists. The purpose of this study was to evaluate the value of mutational analysis of the GNAS gene in differentiating these two conditions. DNA samples from patients with fibrous dysplasia (n=30) and ossifying fibroma (n=21)  were collected to analyze the presence of GNAS mutations at exons 8 and 9, the two previously reported hotspot regions, using polymerase chain reaction and direct sequencing. In all, 90% (27/30) of cases with fibrous dysplasia showed missense mutations of codon 201 at exon 8, with a predilection of arginine-to-histidine substitution (p.R201H, 70%) as opposed to arginine-to-cysteine substitution (p.R201C, 30%), whereas no mutation was detected at exon 9. No mutation was found in all 21 cases with ossifying fibroma. In addition, a meta-analysis of previously published reports on GNAS mutations in fibrous dysplasia and ossifying fibroma was performed to substantiate our findings. A total of 24 reports including 307 cases of fibrous dysplasia and 23 cases of ossifying fibroma were reviewed. The overall incidence of GNAS mutations in fibrous dysplasia was 86% (264/307), and the major types of mutations were also R201H (53%) and R201C (45%). No GNAS mutation was detected in all patients with ossifying fibroma. We also reported one case with uncertain diagnosis due to overlapping clinicopathological features of fibrous dysplasia and ossifying fibroma. An R201H mutation was detected in this case, thus confirming a diagnosis of fibrous dysplasia. Taken together, our findings indicate that mutational analysis of GNAS gene is a reliable adjunct to differentiate ossifying fibroma and fibrous dysplasia of the jaws.Modern Pathology advance online publication, 15 March 2013; doi:10.1038/modpathol.2013.31.

 

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[154]

TÍTULO / TITLE:  - Impact of 18F-FDG PET/CT Imaging in Therapeutic Decisions for Malignant Solitary  Fibrous Tumor of the Pelvis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Mar 11.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e31828165c1

AUTORES / AUTHORS:  - Yan J; Jones RL; Lewis DH; Eary JF

INSTITUCIÓN / INSTITUTION:  - From the * Department of Radiology, University of Washington Medical Center, and  daggerDivision of Medical Oncology, University of Washington Medical Center, Seattle, WA.

RESUMEN / SUMMARY:  - The decision to give neoadjuvant chemotherapy in patients with localized high-risk soft tissue sarcoma is often based on tumor grade evaluated from biopsies, but biopsies can have the inherent issue of sampling bias. Incorporation of SUVmax and heterogeneity assessed by F-FDG PET/CT could be other crucial components in the effort to tailor treatment to an individual patient, providing valuable parameters to guide the selection of the most appropriate management schedule for an individual. We present 1 representative case describing how FDG PET/CT can assist in clinical management decisions for treatment of malignant solitary fibrous tumor of the pelvis.

 

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[155]

TÍTULO / TITLE:  - Intratesticular kaposiform haemangioendothelioma in adults: a report of two cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Pathol. 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1136/jclinpath-2013-201478

AUTORES / AUTHORS:  - Costa FD; Folpe AL

INSTITUCIÓN / INSTITUTION:  - Department of Anatomic Pathology, Hospital AC Camargo, Sao Paulo, SP, Brazil.

RESUMEN / SUMMARY:  - Kaposiform haemangioendothelioma is a very rare vascular tumour of intermediate (borderline) malignancy, typically occurring in the skin and soft tissues of the  extremities in infants and children. We report two morphologically and immunophenotypically classical cases occurring in the testicular parenchyma of old adults, review the literature on vascular tumours of the testis and discuss the differential diagnosis of these unusual cases.

 

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[156]

TÍTULO / TITLE:  - Lipoma of the Colon: Should Asymptomatic Tumors be Treated?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am Surg. 2013 Mar;79(3):335.

AUTORES / AUTHORS:  - Goyal V; Ungsanan P

 

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[157]

TÍTULO / TITLE:  - Implantation of a stent graft in the right pulmonary artery enables radical resection of a central endothelial sarcoma of the left pulmonary artery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Vasc Surg. 2013 Mar 1. pii: S0741-5214(13)00009-8. doi: 10.1016/j.jvs.2012.11.131.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jvs.2012.11.131

AUTORES / AUTHORS:  - Kissling P; Brosi P; Kull C; Toia D; Maurer CA

INSTITUCIÓN / INSTITUTION:  - Department of General, Visceral, Vascular and Thoracic Surgery, Hospital of Liestal, University of Basel, Liestal, Switzerland.

RESUMEN / SUMMARY:  - In a patient with a huge endothelial sarcoma of the left pulmonary artery, we report successful implantation of a stent graft in the right pulmonary artery, including the pulmonary arterial trunk. This preoperative measure enabled a safe  and radical left-sided pneumonectomy, including the tumor and the central parts of the left pulmonary artery. No major blood loss occurred, and neither use of a  heart-lung machine nor cardiopulmonary bypass was necessary.

 

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[158]

TÍTULO / TITLE:  - Diffusion-weighted imaging for evaluation of uterine arterial embolization of fibroids.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Magn Reson Med. 2013 Feb 25. doi: 10.1002/mrm.24624.

            ●● Enlace al texto completo (gratuito o de pago) 1002/mrm.24624

AUTORES / AUTHORS:  - Faye N; Pellerin O; Thiam R; Chammings F; Brisa M; Marques E; Cuenod CA; Sapoval M; Fournier LS

INSTITUCIÓN / INSTITUTION:  - Universite Paris Descartes Sorbonne Paris Cite, INSERM UMR-S970, Cardiovascular Research Center-PARCC, Paris, France.

RESUMEN / SUMMARY:  - PURPOSE: To determine whether diffusion-weighted imaging (DWI) characteristics could predict the effectiveness of uterine arterial embolization in treatment of  fibroids. METHODS: This retrospective study included 17 women (27 fibroids) who underwent uterine arterial embolization for fibroids. MR imaging (1.5 T) was performed before, 1 week and 6 months after uterine arterial embolization. The volume, T2 signal, T1 signal, enhancement after contrast media injection, DWI signal (b = 500 s/mm(2) ) and apparent diffusion coefficient (ADC) were assessed  for fibroids. RESULTS: DWI signal or ADC, whether before or 1 week after the procedure, did not show a statistical relationship to success of uterine arterial embolization. On the 1-week follow-up, 22% of fibroids enhanced vs. 85% on baseline, P < 0.0001 and DW signal intensity increased. ADC values in fibroids decreased between baseline and 1-week (1.61 vs. 1.53 x 10(-3) mm(2) /s, P = 0.13). On 6-months, ADC continued to decrease compared with baseline (1.27 x 10(-3) mm(2) /s, P = 0.002), but with a lower signal on DWI. No changes were observed in myometrium ADC at any time point. CONCLUSION: Our study demonstrated  that DWI and ADC reflected early and delayed changes in fibroids after embolization; however, we were not able to demonstrate a statistically significant relationship with outcome. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.

 

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[159]

TÍTULO / TITLE:  - Src kinases mediate VEGFR2 transactivation by the osteostatin domain of PTHrP to  modulate osteoblastic function.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cell Biochem. 2013 Feb 26. doi: 10.1002/jcb.24482.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jcb.24482

AUTORES / AUTHORS:  - Garcia-Martin A; Acitores A; Maycas M; Villanueva-Penacarrillo ML; Esbrit P

INSTITUCIÓN / INSTITUTION:  - Laboratorio de Metabolismo Mineral y Oseo, Instituto de Investigacion Sanitaria (IIS)-Fundacion Jimenez Diaz and Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad (RETICEF)-Instituto de Salud Carlos III, Madrid, España.

RESUMEN / SUMMARY:  - Parathyroid hormone-related protein (PTHrP) stimulates osteoblastic function through its N- and C-terminal domains. Since the osteogenic action of the latter  domain appears to depend at least in part on its interaction with the vascular endothelial growth factor (VEGF) system, we aimed to explore the putative mechanism underlying this interaction in osteoblasts. Using native conditions for protein extraction and immunoblotting, we found that both PTHrP (107-139) and the shorter PTHrP (107-111) peptide (known as osteostatin), at 100 nM, promoted the appearance of a VEGF receptor (VEGFR) 2 protein band of apparent Mr. wt. 230 kDa, which likely represents its activation by dimer formation, in mouse osteoblastic  MC3T3-E1 cells. Moreover, osteostatin (100 nM) maximally increased VEGFR2 phosphorylation at Tyr-1059 within 5-10 min in both MC3T3-E1 and rat osteoblastic osteosarcoma UMR-106 cells. This phosphorylation elicited by osteostatin appears  to be VEGF-independent, but prevented by the VEGFR2 activation inhibitor SU1498 and also by the Src kinase inhibitors SU6656 and PP1. Furthermore, osteostatin induced phosphorylation of Src, extracellular signal-regulated kinase (ERK) and Akt with a similar time course to that observed for VEGFR2 activation in these osteoblastic cells. This osteostatin-dependent induction of ERK and Akt activation was abrogated by SU6656. Up-regulation of VEGF and osteoprotegerin gene expression as well as the pro-survival effect after osteostatin treatment were all prevented by both SU1498 and SU6656 in these osteoblastic cells. Collectively, these findings demonstrate that the osteostatin domain of C-terminal PTHrP phosphorylates VEGFR2 through src activation, which represents a mechanism for modulating osteoblastic function. J. Cell. Biochem. © 2013 Wiley  Periodicals, Inc.

 

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[160]

TÍTULO / TITLE:  - Decidualized adenomyosis during pregnancy and post delivery: three cases of magnetic resonance imaging findings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Abdom Imaging. 2013 Feb 21.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00261-013-9988-5

AUTORES / AUTHORS:  - Shitano F; Kido A; Fujimoto K; Umeoka S; Himoto Y; Kiguchi K; Kondoh E; Mikami Y; Konishi I; Togashi K

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

RESUMEN / SUMMARY:  - Adenomyosis is a common gynecologic disease. Pregnancy with adenomyosis is on the increase due to a tendency of delay with first pregnancies and various infertility treatments involved in the process. We encountered decidualized adenomyosis in three patients during pregnancy, who were suspected by magnetic resonance (MR) imaging and were followed monitored post delivery. The MR imaging  findings of adenomyosis during pregnancy showed low signal intensity areas with embedded bright foci that expanded to a few mm in diameter on half Fourier single-shot turbo spin-echo images. This finding may reflect decidual change of the stroma within the ectopic endometrium caused during pregnancy. The MR imaging findings of adenomyosis after childbirth showed hemorrhage inside the lesion, which were assumed to be led by rapid decrease in a blood flow to adenomyosis post childbirth.

 

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[161]

TÍTULO / TITLE:  - Inorganic Phosphate as A Signaling Molecule: A Potential Strategy in Osteosarcoma Treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Curr Pharm Des. 2013 Feb 4.

AUTORES / AUTHORS:  - Spina A; Sorvillo L; Esposito A; Borgia A; Sapio L; Naviglio S

INSTITUCIÓN / INSTITUTION:  - Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Medical School, Via L. De Crecchio 7, 80138 Naples, Italy. silvio.naviglio@unina2.it.

RESUMEN / SUMMARY:  - Inorganic phosphate (Pi) is an essential nutrient to living organisms. It plays a key role in diverse biological processes, including osteoblast differentiation and skeletal mineralization. Maintenance of proper Pi homeostasis is a critical event, as any deviation from that state can lead to several acute and chronic disease states and influence the ageing process and lifespan. Serum Pi level is maintained within a narrow range through a complex interplay between intestinal absorption, exchange with intracellular and bone storage pools, renal tubular reabsorption and depends mainly on the activity of Na/Pi cotransporters. Pi is abundant in the diet and intestinal absorption of Pi is efficient and minimally regulated. The kidney is a major regulator of Pi homeostasis and can increase or  decrease its Pi reabsorptive capacity to accommodate Pi need. Relevantly, Pi is emerging as an important signalling molecule capable of modulating multiple cellular functions by altering signal transduction pathways, gene expression and  protein abundance in many cell types. However, little is known about the initial  events involving the detection of changes in serum or local Pi concentrations and the subsequent downstream regulation cascade. Previously, we provided evidence that Pi inhibits proliferation and aggressiveness of human osteosarcoma U2OS cells identifying adenylate cyclase, beta3 integrin, Rap1, ERK1/2 as proteins whose expression and function are relevantly affected in response to Pi. More recently, we demonstrated that Pi is capable also of inducing sensitization of osteosarcoma cells to doxorubicin in a p53-dependent manner and through a mechanism involving ERK1/2 down-regulation. This review summarizes the current knowledge regarding inorganic phosphate as a novel specific signaling molecule in bone and other cell types in mammals and discuss how targeting Pi levels at local sites might represent a potential strategy for improving osteosarcoma therapy.

 

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[162]

TÍTULO / TITLE:  - Genome-wide analyses on high-grade osteosarcoma: Making sense of a genomically most unstable tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Cancer. 2013 Feb 22. doi: 10.1002/ijc.28124.

            ●● Enlace al texto completo (gratuito o de pago) 1002/ijc.28124

AUTORES / AUTHORS:  - Kuijjer ML; Hogendoorn PC; Cleton-Jansen AM

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

RESUMEN / SUMMARY:  - High-grade osteosarcoma is an extremely genomically unstable tumor. This, together with other challenges, such as the heterogeneity within and between tumor samples, and the rarity of the disease, renders it difficult to study this  tumor on a genome-wide level. Now that most laboratories change from genome-wide  microarray experiments to Next-Generation Sequencing it is important to discuss the lessons we have learned from microarray studies. In this review, we discuss the challenges of high-grade osteosarcoma data analysis. We give an overview of microarray studies that have been conducted so far on both osteosarcoma tissue samples and cell lines. We discuss recent findings from integration of different  data types, which is particularly relevant in a tumor with such a complex genomic profile. Finally, we elaborate on the translation of results obtained with bioinformatics into functional studies, which has lead to valuable findings, especially when keeping in mind that no new therapies with a significant impact on survival have been developed in the past decades.

 

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[163]

TÍTULO / TITLE:  - Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experiment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Dermatol Sci. 2013 Mar 6. pii: S0923-1811(13)00064-9. doi: 10.1016/j.jdermsci.2013.02.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jdermsci.2013.02.008

AUTORES / AUTHORS:  - Hoshina D; Abe R; Yoshioka N; Saito N; Hata H; Fujita Y; Aoyagi S; Shimizu H

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

RESUMEN / SUMMARY:  - BACKGROUND: Angiosarcoma is one of the most life-threatening neoplasms with strong resistance to conventional chemotherapy/radiotherapy; consequently, alternative therapeutic agents are urgently required. One factor in delaying the  therapy development is the limitation of experimental models. OBJECTIVE: We established a novel experimental angiosarcoma model. METHODS: From surgically resected tissue, human AS cell line was established. Using xenograft of AS cell line, we performed therapeutic experiments with the anti-human VEGF Ab or the receptor tyrosine kinase inhibitor. RESULTS: First we generated an angiosarcoma cell line, HAMON (human angiosarcoma, monoclonal), which expresses CD31 and produces tumors in immunodeficient mice. HAMON expresses VEGFR2 and that exogenous VEGF leads to HAMON proliferation in vitro. Anti-human VEGF Ab bevacizumab treatment failed to suppress HAMON proliferation in vitro and in vivo. Furthermore, the receptor tyrosine kinase inhibitor sunitinib did not suppress HAMON proliferation in vitro. Similarly, in in vivo therapeutic experiments, even high doses of sunitinib failed to inhibit tumor growth. Finally, we checked whether compensatory activation of VEGF signaling occurred after sunitinib addition. VEGF protein secretion, VEGF mRNA synthesis and VEGFR2  phosphorylation all were unaffected in HAMON after sunitinib treatment. CONCLUSION: A novel in vitro and in vivo experimental model of human angiosarcoma has been successfully established. With this model, we were able to perform therapeutic experiments. In addition, our angiosarcoma cell line, HAMON, is quite useful for identifying key molecules in angiosarcoma.

 

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[164]

TÍTULO / TITLE:  - Pinacidil stimulates osteoblast function in osteoblastic MC3T3-E1 cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Immunopharmacol Immunotoxicol. 2013 Mar 6.

            ●● Enlace al texto completo (gratuito o de pago) 3109/08923973.2013.773447

AUTORES / AUTHORS:  - Suh KS; Lee YS; Choi EM

INSTITUCIÓN / INSTITUTION:  - Research Institute of Endocrinology, Kyung Hee University Hospital , Seoul , Republic of Korea and.

RESUMEN / SUMMARY:  - Abstract This study examined the effect of pinacidil, a nonselective adenosine triphosphate-sensitive potassium channel opener, on the function of osteoblastic  MC3T3-E1 cells. Pinacidil caused a significant elevation of collagen synthesis, alkaline phosphatase activity, osteocalcin synthesis and mineralization in the cells (p < 0.05). Pinacidil significantly decreased the production of osteoclast  differentiation inducing factors such as TNF-alpha, IL-6 and receptor activator of nuclear factor-kappaB ligand in the presence of antimycin A, which inhibits mitochondrial electron transport. Moreover, pinacidil prevented antimycin A-induced reactive oxygen species and nitrotyrosine production. These results demonstrate that pinacidil may have positive effects on skeletal structure.

 

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[165]

TÍTULO / TITLE:  - MED12 exon 2 mutations in histopathological uterine leiomyoma variants.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Hum Genet. 2013 Feb 27. doi: 10.1038/ejhg.2013.33.

            ●● Enlace al texto completo (gratuito o de pago) 1038/ejhg.2013.33

AUTORES / AUTHORS:  - Makinen N; Vahteristo P; Kampjarvi K; Arola J; Butzow R; Aaltonen LA

INSTITUCIÓN / INSTITUTION:  - Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

RESUMEN / SUMMARY:  - Uterine leiomyomas, or fibroids, are the most common human tumors. Based on histopathology, they can be divided into common leiomyomas and various relatively rare subtypes that mimic malignancy in one or more aspects. Recently, we showed that exon 2 of mediator complex subunit 12 (MED12) is mutated in up to 70% of common fibroids. To investigate the frequency of MED12 exon 2 mutations in histopathological uterine leiomyoma variants, we screened altogether 206 lesions, including 69 histopathologically common leiomyomas, 59 cellular (23 cellular and  36 highly cellular), 18 atypical and 26 mitotically active leiomyomas, as well as 34 uterine fibroid samples from 14 hereditary leiomyomatosis and renal cell cancer patients with a heterozygous germ line mutation in fumarate hydratase (FH). The uterine leiomyoma variants harbored MED12 exon 2 mutations significantly less frequently than common leiomyomas (P=2.93 x 10(-8)). In all, 6 mutations were detected among cellular fibroids (6/67; 8.96%), 3 among atypical fibroids (3/18; 16.67%) and 10 among mitotically active fibroids (10/26; 38.46%). Only mitotically active fibroids displayed a mutation frequency that was not statistically different from common leiomyomas (P=0.11). Three MED12 exon 2 mutations were detected among 34 tumors with a heterozygous germ line FH mutation (P=5.28 x 10(-7)). None of these tumors displayed biallelic inactivation of FH. Our results suggest that MED12 mutation positivity is a key characteristic of common leiomyomas. Cellular and atypical fibroids, in particular, may arise through different molecular mechanisms. The results also propose that MED12 and biallelic FH mutations may be mutually exclusive.European Journal of Human Genetics advance online publication, 27 February 2013; doi:10.1038/ejhg.2013.33.

 

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[166]

TÍTULO / TITLE:  - Fuyuan Decoction inhibits nitric oxide production via inactivation of nuclear factor-kappaB in SW1353 chondrosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Ethnopharmacol. 2013 Apr 19;146(3):853-8. doi: 10.1016/j.jep.2013.02.014. Epub  2013 Mar 1.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jep.2013.02.014

AUTORES / AUTHORS:  - Jia P; Chen G; Zhou G; Zhong Y; Li R

INSTITUCIÓN / INSTITUTION:  - Department of Combination of Chinese and Western Medicine, the First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016, PR China. Electronic address: jiap008@yahoo.com.cn.

RESUMEN / SUMMARY:  - ETHNOPHARMACOLOGICAL RELEVANCE: Fuyuan Decoction (FYD) is an empirical formula of treating Bi Zheng in traditional Chinese medicine (TCM). Despite the fact that the efficiency of FYD on treating osteoarthritis has been verified in clinic, the underlying mechanisms are not totally understood. This study was to investigate the effects and mechanisms of FYD on nitric oxide (NO) production and nuclear factor (NF)-kappaB activation in interleukin (IL)-1beta-stimulated chondrocytes.  MATERIALS AND METHODS: SW1353 human chondrosarcoma cells were pretreated with various concentrations of FYD-containing serum (FYD-CS), and then were stimulated by IL-1beta. Amounts of NO were determined by Griess reaction assay. Inducible NO synthase (iNOS) expression, inhibitor-kappaBalpha (IkappaBalpha) degradation and  nuclear translocation of p65 protein were determined by Western blot assay. DNA binding activity of NF-kappaB was determined by ELISA assay using Trans AM() kit  for p65. RESULTS: 10% and 20% (v/v) FYD-CS significantly decreased NO production  in a concentration-dependent manner (p<0.05 or p<0.01) as compared to control in  IL-1beta-induced SW1353 cells. Besides, 10% and 20% FYD-CS also significantly reduced iNOS protein expression by about 60% and 70% (both p<0.01), respectively. Furthermore, 10% and 20% FYD-CS markedly decreased IkappaBalpha degradation by about 45% and 26% (p<0.01 or p<0.05), lessened P65 content in the nucleus by about 28% and 60% (both p<0.01), and repressed DNA binding activity of P65 by about 30% and 45% (both p<0.01) in IL-1beta-induced SW1353 cells. CONCLUSIONS: These findings suggested that FYD could inhibit NO production and iNOS expression in IL-1beta-induced chondrocytes through suppressing NF-kappaB activation.

 

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[167]

TÍTULO / TITLE:  - Successful treatment of an unresectable inflammatory myofibroblastic tumor of the frontal bone using a cyclooxygenase-2 inhibitor and methotrexate.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Intern Med. 2013;52(5):623-8. Epub 2013 Mar 1.

AUTORES / AUTHORS:  - Kusunoki-Nakamoto F; Matsukawa T; Tanaka M; Miyagawa T; Yamamoto T; Shimizu J; Ikemura M; Shibahara J; Tsuji S

INSTITUCIÓN / INSTITUTION:  - Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumor (IMT) is a disease characterized by tumorous lesions consisting of myofibroblastic spindle cells and inflammatory cells that occur primarily in the soft tissues and viscera of children and young adults. Total excision is the most effective therapy. Steroids have been used to treat unresectable lesions with some success. We herein report a case of IMT involving  the frontal bone accompanied by pachymeningitis. The tumor was characterized by an aggressive clinical course that was refractory to prednisolone. Performing total excision seemed difficult. Celecoxib and methotrexate were effective treatments. Our experience suggests the efficacy of celecoxib and methotrexate as alternatives for treating unresectable IMT.

 

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[168]

TÍTULO / TITLE:  - High expression of survivin in sacral chordoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Jun;30(2):529. doi: 10.1007/s12032-013-0529-4. Epub 2013 Mar 16.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-013-0529-4

AUTORES / AUTHORS:  - Chen C; Yang HL; Chen KW; Wang GL; Lu J; Yuan Q; Gu YP; Luo ZP

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, 1st Affiliated Hospital and Orthopedic Institute, Soochow University, Suzhou 215007, Jiangsu, China.

RESUMEN / SUMMARY:  - Chordoma is a rare and invasive malignant tumor which primarily relies on surgical treatments. Anticipation of its recurrence and patient survival longevity has been a critical issue of the treatments. This retrospective study examined the survivin expression of sacral chordoma in 30 patients undergoing surgery in our hospital from January 2000 to July 2010, and compared it with chordoma recurrence. Survivin expression was 70 % positive in 30 patients. The positive expression of survivin with recurrence was significantly higher than that without recurrence (p = 0.017) and was inversely related to the continuous disease-free survival time (p < 0.001). Survivin expression was associated with recurrence. The correlation suggested that the survivin expression could be used  as an independent predictor of recurrence and could be a potential bio-target gene of angiogenesis in sacral chordoma.

 

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[169]

TÍTULO / TITLE:  - The AIDS epidemic, then and now.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Am Acad Dermatol. 2013 Mar;68(3):507-8. doi: 10.1016/j.jaad.2012.10.020.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jaad.2012.10.020

AUTORES / AUTHORS:  - Conant MA

INSTITUCIÓN / INSTITUTION:  - University of California Medical Center, San Francisco, California 94114-2512, USA. marcconant@hotmail.com

 

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[170]

TÍTULO / TITLE:  - CT and MRI of radiation-induced sarcomas of the head and neck following radiotherapy for nasopharyngeal carcinoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Radiol. 2013 Mar 8. pii: S0009-9260(13)00033-0. doi: 10.1016/j.crad.2013.01.004.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.crad.2013.01.004

AUTORES / AUTHORS:  - Cai PQ; Wu YP; Li L; Zhang R; Xie CM; Wu PH; Xu JH

INSTITUCIÓN / INSTITUTION:  - State Key Laboratory of Oncology in South China, 651 Dongfengdong Road, Guangzhou, Guangdong 510060, PR China; Department of Radiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, PR China.

RESUMEN / SUMMARY:  - AIM: To investigate the radiological findings of head and neck radiation-induced  sarcomas (RISs) following radiotherapy for nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: Fifty-nine patients with RISs were identified. Imaging characteristics on computed tomography (CT) and magnetic resonance imaging (MRI), including lesion location, extent, size, margin, internal architecture, pattern,  and degree of enhancement, together with patient characteristics at NPC diagnosis and latency periods, were reviewed. RESULTS: The study included 20 women and 39 men, with a median age of 49 years (range 30-71 years). The median latency was 9  years (range 3-37 years). The median radiation dose at the site of RIS was 66 Gy  (range 44-78 Gy). The most common histological RIS types were fibrosarcoma (44.1%) and osteosarcoma (30.5%). The most common RIS sites were the paranasal sinuses and the nasal cavity (39%), the neck (16.9%), and the mandible (15.3%). The mean size was 5.1 cm (range 1.2-8.6 cm). Overall, 78% of lesions extended to  adjacent spaces and 66.1% were accompanied by bone destruction. Heterogeneous density/signal intensity before and after enhancement was seen in all lesions on  imaging. Marked lesion enhancement was noted in 49 cases (76.3%). CONCLUSIONS: The radiologist should be aware of the different sites at which RISs occur and the radiological appearance of the wide variety of RIS subtypes. Careful imaging  follow-up is necessary for early detection of RISs in patients with NPC after radiotherapy.

 

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[171]

TÍTULO / TITLE:  - A Population-based Series of Ovarian Carcinosarcomas with Long-term Follow-up.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anticancer Res. 2013 Mar;33(3):1003-8.

AUTORES / AUTHORS:  - Paulsson G; Andersson S; Sorbe B

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, University Hospital, SE-701 85 Orebro, Sweden. bengt.sorbe@orebroll.se.

RESUMEN / SUMMARY:  - Aim: The aim of the present study was to evaluate a consecutive series of ovarian carcinosarcomas with regard to prognosis, treatment and prognostic factors. PATIENTS AND METHODS: A consecutive series of 81 ovarian carcinosarcomas from two well-defined geographic regions were studied with regard to survival, type of primary and adjuvant therapy and prognostic factors. All patients but one underwent primary surgery and some patients also received adjuvant chemotherapy (platinum-based) alone or in combination with radiotherapy. Univariate and multivariate Cox proportional regression analysis was used. Survival was analyzed by the Kaplan-Meier technique and differences were assessed by the log-rank test. RESULTS: The mean age of the patients was 73 years. Fifty-one patients received adjuvant chemotherapy and nine patients pelvic irradiation. The 5-year overall survival rate was 10%. Adjuvant therapy (any type) and six completed cycles of chemotherapy were highly significant factors with regard to improved overall survival rate. The only significant tumor-associated prognostic factor was the International Federation of Gynecology and Obstetrics (FIGO) grade of the tumor.  FIGO stage, site of metastatic spread, tumor size, histology, DNA ploidy, and tumor necrosis were non-significant factors. Therapy was rather well-tolerated and 29 patients (57%) completed at least six cycles of adjuvant chemotherapy. CONCLUSION: Adjuvant and completed chemotherapy according to the treatment plan were the most important prognostic factors. FIGO grade (grade 3 vs. 1-2) of the epithelial component of the tumor was also a significant prognostic factor in multivariate Cox analysis.

 

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[172]

TÍTULO / TITLE:  - Use of PAX8 and GATA3 in diagnosing sarcomatoid renal cell carcinoma and sarcomatoid urothelial carcinoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Feb 28. pii: S0046-8177(13)00011-7. doi: 10.1016/j.humpath.2012.12.012.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.12.012

AUTORES / AUTHORS:  - Chang A; Brimo F; Montgomery EA; Epstein JI

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA.

RESUMEN / SUMMARY:  - Immunohistochemistry for PAX8 and GATA3 are sensitive markers for renal cell carcinoma and urothelial carcinoma, respectively. However, there are limited data on these markers in sarcomatoid renal cell carcinoma (SARCRCC) and sarcomatoid urothelial carcinoma (SARCUC). Tissue microarrays (TMAs) were constructed from 45 cases of SARCRCC and 45 cases of SARCUC of the lower urinary tract, with an additional 11 SARCUCs of the upper tract. PAX8 and GATA3 were also evaluated in TMAs from 161 sarcomas from other sites, 14 atypical epithelioid angiomyolipomas  (AMLs) of the kidney, 23 bladder inflammatory myofibroblastic tumors (IMTs), and  2 bladder and 4 renal leiomyosarcomas. In the SARCRCC, PAX8 and GATA3 were positive in the sarcomatoid areas in 31 (69%) and 0 (0%) of cases, respectively.  In the bladder SARCUC, GATA3 and PAX8 were positive in 14 (31%) and 2 (4%) of cases, respectively. Of the 11 SARCUCs of the upper urinary tract, 2 (18%) cases  were PAX8 positive and 2 (18%) separate cases were GATA3 positive. Only 1 tumor present on the sarcoma TMAs, a Ewing sarcoma/primitive neuroectodermal tumor, was PAX8 positive, and all sarcomas were GATA3 negative. Of the AMLs, IMTs, and leiomyosarcoma, only 1 case of IMT showed moderate GATA3 positivity, and all were negative for PAX8. PAX8 can be used to distinguish SARCCRCC from atypical epithelioid AMLs and primary renal or retroperitoneal sarcomas. However, in a kidney/renal pelvic tumor, PAX8 shows overlap in staining between SARCUC and SARCRCC. GATA3 lacks sensitivity but is more specific for SARCUC.

 

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[173]

TÍTULO / TITLE:  - Monitoring the Adequacy of Surgical Margins After Resection of Bone and Soft-Tissue Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Surg Oncol. 2013 Jan 31.

            ●● Enlace al texto completo (gratuito o de pago) 1245/s10434-012-2863-8

AUTORES / AUTHORS:  - Biau DJ; Weiss KR; Bhumbra RS; Davidson D; Brown C; Griffin A; Wunder JS; Ferguson PC

INSTITUCIÓN / INSTITUTION:  - Departement de chirurgie orthopedique, Hopital Cochin, Paris, France, david.biau@cch.aphp.fr.

RESUMEN / SUMMARY:  - PURPOSE: Local recurrence of a bone or soft-tissue sarcoma is a devastating complication. Minimizing the proportion of positive surgical margins, or tumor contamination, during resection is of paramount importance. METHODS: Resections of sarcomas were prospectively evaluated and considered inadequate if unplanned microscopic or macroscopic positive surgical margins were identified or if inadvertent tumor contamination of the wound occurred. Monitoring of performance  was continuously performed with a statistical process control method, the cumulative sum test, and regular meetings were held to discuss the reasons for failures. A target performance of 5 % inadequate procedures was chosen. RESULTS:  A total of 146 sarcomas-106 soft tissue and 40 bone-were resected during the monitoring period. Six (4 %) procedures were considered inadequate: three patients had inadvertent tumor contamination of the wound, two patients had unplanned microscopic positive margins, and one patient had both. Performance was considered to be adequate during the whole monitoring period. CONCLUSIONS: With adequate preoperative planning and surgical technique, the risk of an inadequate  resection can be limited. Implementation of a statistical process control method  allows for ongoing performance monitoring and ensures that quality remains adequate over time.

 

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[174]

TÍTULO / TITLE:  - Diagnostic and prognostic morphometric features in WHO2003 invasive endometrial stromal tumours.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Histopathology. 2013 Apr;62(5):688-694. doi: 10.1111/j.1365-2559.2011.04120.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1365-2559.2011.04120.x

AUTORES / AUTHORS:  - Feng W; Malpica A; Yinhua Y; Janssen E; Gudlaugsson E; Zhou X; Baak JP

INSTITUCIÓN / INSTITUTION:  - Department of Gynaecology and Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China Departments of Pathology and Gynecologic Oncology Department of Experimental Therapeutics, the University of Texas MD Anderson Cancer Center, Houston, TX, USA Department of Pathology, Stavanger University Hospital, Stavanger The Gade Institute, University of Bergen, Bergen, Norway Department of Pathology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.

RESUMEN / SUMMARY:  - Aims: The aim of this study was to determine the value of morphometric features in distinguishing mild and moderate atypia and predicting the recurrence of World Health Organization 2003-defined endometrial stromal sarcoma and highly malignant undifferentiated endometrial sarcoma. Methods and results: Nuclear and cytological size, shape and arrangement were morphometrically evaluated in 41 cases with consensus no/mild (n = 38) or moderate (n = 3) atypia. None of the cases showed necrosis. The prognostic value of these features in predicting recurrence was also assessed. Seven features differed. The mean and standard deviation of the nuclear volume and the distance between the nuclei were the best discriminators between the no/mild and moderate atypia, with the maximum of the nuclear volume being a practically and rapidly evaluable alternative. With the use of these features, all mild and moderate atypias were correctly classified. Seven cases recurred. The distance between the nuclei and the percentage of nuclei with one neighbour (assessed with morphometric minimum spanning tree analysis) predicted recurrence. Conclusions: In invasive endometrial stromal tumours, morphometric features are useful diagnostic support tools for distinguishing mild from moderate atypia and predicting recurrence.

 

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[175]

TÍTULO / TITLE:  - Radiographic Superimposition and Mandibular Peripheral Osteoma: The Importance of Clinical and CT Findings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniofac Surg. 2013 Mar;24(2):e141-2. doi: 10.1097/SCS.0b013e31827c7e87.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SCS.0b013e31827c7e87

AUTORES / AUTHORS:  - Boffano P; Gallesio C; Roccia F; Berrone S

INSTITUCIÓN / INSTITUTION:  - From the Division of Maxillofacial Surgery, Head and Neck Department, San Giovanni Battista Hospital, University of Turin, Turin, Italy.

RESUMEN / SUMMARY:  - Peripheral osteomas are benign, slow-growing osteogenic tumors that are caused by centrifugal growth of the periosteum and develop as masses attached to the cortical plates.The pathogenesis of osteomas is unclear, and embryologic, traumatic, inflammatory, metaplastic, and genetic causes have been proposed. A solitary peripheral osteoma of the jaws is uncommon.The purpose of this paper is  to present a peculiar case of mandibular peripheral osteoma with a particular radiographic superimposition that stress the importance of clinical and CT findings.

 

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[176]

TÍTULO / TITLE:  - Clinical benefit of trabectedin in uterine adenosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Jun;30(2):501. doi: 10.1007/s12032-013-0501-3. Epub 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-013-0501-3

AUTORES / AUTHORS:  - Schroeder BA; Rodler ET; Loggers ET; Pollack SM; Jones RL

INSTITUCIÓN / INSTITUTION:  - Fred Hutchinson Cancer Research Center, University of Washington, 825 Eastlake Avenue East, Seattle, WA, USA.

RESUMEN / SUMMARY:  - Uterine adenosarcoma is an extremely rare uterine malignancy, and the utility of  chemotherapy in this disease is not well defined. This study assessed the safety  and efficacy of trabectedin in patients with recurrent/metastatic uterine adenosarcoma with sarcomatous overgrowth. A retrospective search of a prospectively maintained database was performed to identify patients with adenosarcoma treated with trabectedin between 2010 and 2012, within a compassionate use trial. Three patients with recurrent/metastatic uterine adenosarcoma treated with trabectedin were identified. All three patients tolerated the drug well. Two patients obtained prolonged clinical benefit from treatment, one having received 17 cycles and another 11 cycles of therapy. Trabectedin is well tolerated and has clinical activity in recurrent/metastatic uterine adenosarcoma.

 

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[177]

TÍTULO / TITLE:  - An unusual mole: an adult case of Dabska tumour.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Coll Antropol. 2012 Nov;36 Suppl 2:171-2.

AUTORES / AUTHORS:  - Bernic A; Novosel I; Krizanac S

INSTITUCIÓN / INSTITUTION:  - Dr. Ivo Pedisic, General Hospital, Department of ENT Surgery, Sisak, Croatia. abernic@gmail.com

RESUMEN / SUMMARY:  - In 1969 Dabska and her colleagues described for the first time this rare malignant tumour, also later known as a malignant endovascular papillary angioendothelioma of childhood. Overall, depending amongst other factors on its location, it is thought to have a generally favourable prognosis and a wide local excision seems to be the treatment of choice. We here present a very rare and unusual case of a 63 year old woman with a 20 year history of slow-growing right  buccal dermatological lesion which resembled a common mole. The histopathological diagnosis of Dabska Tumour was made following the hematoxylin and eosin (H&E) biopsy. The analysis revealed multiple delicate interconnecting vascular channels with papillary plugs, some of which containing hyalinized core, projecting into the lumen lined by atypical plumped endothelial cells.

 

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[178]

TÍTULO / TITLE:  - Evidence for Ca-regulated ATP release in gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Cell Res. 2013 Mar 13. pii: S0014-4827(13)00109-2. doi: 10.1016/j.yexcr.2013.03.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.yexcr.2013.03.001

AUTORES / AUTHORS:  - Berglund E; Berglund D; Akcakaya P; Ghaderi M; Dare E; Berggren PO; Kohler M; Aspinwall CA; Lui WO; Zedenius J; Larsson C; Branstrom R

INSTITUCIÓN / INSTITUTION:  - Section for Endocrine and Sarcoma Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Department of Breast and Endocrine Surgery, Karolinska University Hospital, L1:03, Stockholm, Sweden.  Electronic address: erik.berglund@ki.se.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs) are thought to originate from the electrically active pacemaker cells of the gastrointestinal tract. Despite the presence of synaptic-like vesicles and proteins involved in cell secretion it remains unclear whether GIST cells possess regulated release mechanisms. The GIST tumor cell line GIST882 was used as a model cell system, and stimulus-release coupling was investigated by confocal microscopy of cytoplasmic free Ca2+ concentration ([Ca2+]i), flow cytometry, and luminometric measurements of extracellular ATP. We demonstrate that GIST cells have an intact intracellular Ca2+-signaling pathway that regulates ATP release. Cell viability and cell membrane integrity was preserved, excluding ATP leakage due to cell death and suggesting active ATP release. The stimulus-secretion signal transduction is at least partly dependent on Ca2+ influx since exclusion of extracellular Ca2+ diminishes the ATP release. We conclude that measurements of ATP release in GISTs may be a useful tool for dissecting the signal transduction pathway, mapping exocytotic components, and possibly for the development and evaluation of drugs.  Additionally, release of ATP from GISTs may have importance for tumor tissue homeostasis and immune surveillance escape.

 

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[179]

TÍTULO / TITLE:  - Multiple papillary fibroelastomas as a cause of recurrent syncope.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Thorac Cardiovasc Surg. 2013 Feb 8. pii: S0022-5223(13)00033-0. doi: 10.1016/j.jtcvs.2013.01.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jtcvs.2013.01.008

AUTORES / AUTHORS:  - Jonjev ZS; Torbica V; Mojasevic R

INSTITUCIÓN / INSTITUTION:  - Clinic of Cardiovascular Surgery, Institute for Cardiovascular Diseases of Vojvodina, University in Novi Sad, Sremska Kamenica, Serbia. Electronic address:  jonjevz@lycos.com.

 

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[180]

TÍTULO / TITLE:  - Diagnostic utility of aP2/FABP4 expression in soft tissue tumours.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Virchows Arch. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00428-013-1392-6

AUTORES / AUTHORS:  - Kashima TG; Turley H; Dongre A; Pezzella F; Athanasou NA

INSTITUCIÓN / INSTITUTION:  - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX7, HE, UK.

RESUMEN / SUMMARY:  - Adipocyte P2 (aP2), also known as fatty acid-binding protein 4 (FABP4), is a fatty acid-binding protein found in the cytoplasm of cells of adipocyte differentiation. In this study, we examined a large number of soft tissue tumours with a commercial polyclonal anti-aP2/FABP4 antibody and a newly developed mouse  monoclonal antibody raised against this protein to determine the diagnostic utility of aP2/FABP4 as a marker of tumours of adipose differentiation. A mouse monoclonal antibody, clone 175d, was raised against a mixture of synthetic peptides corresponding to the amino acid sequence of residues 10-28 and 121-132 of the human aP2/FABP4 protein. Antigen expression with polyclonal and monoclonal antibodies was immunohistochemically determined in paraffin sections of normal adipose tissue and a wide range of benign and malignant primary soft tissue tumours (n = 200). aP2/FABP4 was expressed around the cytoplasmic lipid vacuole in white and brown fat cells in benign lipomas and hibernomas. Immature fat cells and lipoblasts in spindle cell/pleomorphic lipoma, atypical lipomatous tumour/well-differentiated liposarcoma, myxoid/round cell liposarcoma and pleomorphic liposarcoma also reacted strongly for aP2/FABP4. No specific staining was seen in non-adipose benign and malignant mesenchymal and non-mesenchymal tumours. aP2/FABP4 is expressed by mature and immature fat cells and is a marker  of tumours of adipose differentiation. Immunophenotypic aP2/FABP4 expression is useful in identifying lipoblasts, and immunohistochemistry with polyclonal/monoclonal anti-aP2/FABP4 antibodies should be useful in distinguishing liposarcoma from other malignancies, particularly round cell, myxoid and pleomorphic soft tissue sarcomas.

 

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[181]

TÍTULO / TITLE:  - Risedronate increases osteoblastic differentiation and function through connexin43.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochem Biophys Res Commun. 2013 Mar 1;432(1):152-6. doi: 10.1016/j.bbrc.2013.01.068. Epub 2013 Jan 29.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bbrc.2013.01.068

AUTORES / AUTHORS:  - Jeong HM; Jin YH; Choi YH; Chung JO; Cho DH; Chung MY; Civitelli R; Chung DJ; Lee KY

INSTITUCIÓN / INSTITUTION:  - College of Pharmacy and Research Institute of Drug Development, Chonnam National  University, Gwangju 500-757, Republic of Korea.

RESUMEN / SUMMARY:  - Bisphosphonates are potent antiresorptive drugs which have antifracture efficacy  by reducing bone turnover rate and increasing bone mineral density. In addition to inhibiting osteoclast function, bisphosphonates have been reported to also promote survival of osteocyte and osteoblast via an anti-apoptotic effect, mediated by opening of hemi-gap junction channels formed by connexin43 (Cx43). In this study, we investigated the effect of risedronate, one amino-bisphosphonate,  on osteoblast differentiation and Cx43 expression using the mesenchymal cell line C2C12. Risedronate dose-dependently increased the activity of osterix (OSE)-luciferase containing Runx2 response element with highest activity at 50muM. The activity of osteocalcin (OC)- and bone sialoprotein (BSP)-luciferase reporters, markers of osteoblast differentiation, were also increased by risedronate. When risedronate and BMP2 were used in combination, alkaline phosphatase (ALP) activity increased to a larger extent than when BMP2 was used alone. Risedronate as well as the pro-osteogenic transcription factors, Runx2, Osterix or Dlx5, increased transcriptional activity of the Cx43 promoter in a dose-dependent manner. In the presence of Runx2 or Dlx5, risedronate had an additive effect on Cx43 promoter activity. Accordingly, risedronate increased protein expression of Cx43, Runx2, Osterix, and Dlx5. These results suggest that  risedronate promotes osteoblastic differentiation and positively regulates Cx43 gene transcription.

 

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[182]

TÍTULO / TITLE:  - miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2  pathway in osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - FEBS Lett. 2013 Mar 15. pii: S0014-5793(13)00205-6. doi: 10.1016/j.febslet.2013.03.007.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.febslet.2013.03.007

AUTORES / AUTHORS:  - Chen L; Wang Q; Wang GD; Wang HS; Huang Y; Liu XM; Cai XH

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics Surgery, Wuhan General Hospital of Guangzhou Command,  Wuhan, China.

RESUMEN / SUMMARY:  - Several miRNAs have been implicated in the development and progression of osteosarcoma (OS). In this study, we found that miR-16 is downregulated in OS cell lines and tissues. Overexpression of miR-16 suppresses OS cell proliferation and tumor growth in nude mice. Furthermore, we confirmed that IGF1R is a direct target of miR-16. Mechanistic investigation revealed that miR-16 overexpression inhibits the Raf1-MEK1/2-ERK1/2 pathway. In clinical specimens, IGF1R levels inversely correlate with miR-16 expression. Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS.

 

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[183]

TÍTULO / TITLE:  - Pyomyoma after uterine artery embolization.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Obstet Gynecol. 2013 Feb;121(2 Pt 2 Suppl 1):431-3. doi: 10.1097/AOG.0b013e31827e8e8f.

AUTORES / AUTHORS:  - Rosen ML; Anderson ML; Hawkins SM

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics & Gynecology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA.

RESUMEN / SUMMARY:  - BACKGROUND: Pyomyoma (suppurative leiomyoma of the uterus) is a rare condition resulting from infarction and infection of a leiomyoma. It can lead to sepsis and death unless treated with antibiotics and aggressive surgical intervention. CASE: A 47-year-old multigravid woman with symptomatic uterine leiomyomas presented with fever, pelvic pain, and leukocytosis after uncomplicated uterine artery embolization. Pyomyoma was suspected after computed tomography scan demonstrated  an enlarged, heterogeneous uterus containing copious myometrial air. She underwent supracervical hysterectomy, lysis of adhesions, and right salpingo-oophorectomy. CONCLUSION: Surgical management of pyomyoma may be necessary early in the management of pyomyoma after uterine artery embolization.

 

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[184]

TÍTULO / TITLE:  - Iliocaval and aortoiliac reconstruction following en bloc retroperitoneal leiomyosarcoma resection.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Vasc Surg. 2013 Mar;57(3):850. doi: 10.1016/j.jvs.2012.01.048.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jvs.2012.01.048

AUTORES / AUTHORS:  - Ohman JW; Chandra V; Poultsides G; Harris EJ

INSTITUCIÓN / INSTITUTION:  - Department of Cardiothoracic and Vascular Surgery, The University of Texas Health Science Center at Houston, Houston, Tex.

 

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[185]

TÍTULO / TITLE:  - Dermoscopy of dermatofibrosarcoma protuberans: a study of 15 cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Dermatol. 2013 Mar 18. doi: 10.1111/bjd.12318.

            ●● Enlace al texto completo (gratuito o de pago) 1111/bjd.12318

AUTORES / AUTHORS:  - Bernard J; Poulalhon N; Argenziano G; Debarbieux S; Dalle S; Thomas L

INSTITUCIÓN / INSTITUTION:  - Department of dermatology, Lyon 1 university, Centre Hospitalier Lyon Sud, 69495, Pierre Benite Cedex, France.

RESUMEN / SUMMARY:  - BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare malignant cutaneous  tumour of which diagnosis is often delayed because of the lack of early clinical  clues. OBJECTIVES: To describe the main dermoscopic features of DFSP. METHODS: We performed dermoscopic examination in 15 unselected, consecutive cases of biopsy-proven DFSP. First, six dermoscopic features were identified collegially;  then all cases were reviewed separately by 6 experimented dermoscopists. In a given lesion, only features recognised by all dermoscopists were taken into account. RESULTS: The median number of dermoscopic features was 4 per lesion. The following dermoscopic features were found: delicate pigmented network (87%); vessels (80%); structureless light brown areas (73%); shiny white streaks (67%);  pink background coloration (67%) and structureless hypo- or depigmented areas (60%). When detected, vessels were of arborizing type in 11 of 12 cases, and presented as either unfocused only, or both unfocused and focused. CONCLUSIONS: this first approach to the dermoscopic spectrum of DFSP identifies 6 dermoscopic  features (often associated in a multicomponent pattern) and a peculiar vascular pattern. Whether dermoscopy can help suspect DFSP remains to be established by further studies.

 

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[186]

TÍTULO / TITLE:  - Severe rhizomelic chondrodysplasia punctata in a fetus due to maternal mixed connective tissue disorder.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genet Couns. 2012;23(4):487-91.

AUTORES / AUTHORS:  - Nayak SS; Adiga PK; Rai L; Girisha KM

INSTITUCIÓN / INSTITUTION:  - Division of Medical Genetics, Department of Pediatrics, Kasturba Medical College, Manipal University, Manipal, India.

RESUMEN / SUMMARY:  - Maternal systemic lupus erythematosus and autoimmune diseases have been extremely rarely reported to cause rhizomelic chondrodysplasia punctata. We report on a fetus aborted spontaneously at 21 weeks of gestation due to complications of maternal mixed connective tissue disorder. The fetus had micrognathia, a depressed nasal bridge, flat nose, long philtrum, short columella and rhizomelia. Radiographic study showed stippling of carpal and tarsal bones, short humeri and  coronal clefts in the vertebrae. Ossification centers were present at the lower end of the femora and upper end of the tibiae.

 

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[187]

TÍTULO / TITLE:  - Kaposis sarcoma-associated herpesvirus ORF36 protein induces chromosome condensation and phosphorylation of histone H3.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Virol. 2013;57(1):75-9.

AUTORES / AUTHORS:  - Kim S; Cha S; Jang JH; Kim Y; Seo T

RESUMEN / SUMMARY:  - Kaposis sarcoma-associated herpesvirus (KSHV) has been known as an agent causing  Kaposis sarcoma, primary effusion lymphoma, and multicentric Castlemans disease.  In the lytic phase of the virus cycle, various viral genes are expressed, which causes host cell dysregulation. Among the lytic genes, viral protein kinase (vPK) encoded by ORF36 is a member of serine/threonine protein kinase (CHPK) family, which is involved in viral gene expression, viral DNA replication and encapsidation, and nuclear egress of virions. Recent studies have shown that the  BGLF4 protein of Epstein-Barr virus (EBV), a member of the CHPK family, alters the host cell chromatin structure through phosphorylation of its key regulators.  The role of KSHV ORF36 in cellular mitotic events, however, is not yet understood. In the current study, we showed that KSHV ORF36 induced chromosome condensation and phosphorylation of histone H3 on Ser 10, which are known as cellular mitosis markers. These processes have occurred in a kinase activity-dependent manner. Keywords: Kaposis sarcoma-associated herpesvirus; viral protein kinase; ORF36; chromosome condensation; histone H3; phosphorylation.

 

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[188]

TÍTULO / TITLE:  - Expression of receptor for hyaluronan-mediated motility (RHAMM) in ossifying fibromas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Histol Histopathol. 2013 Apr;28(4):473-80. Epub 2013 Feb 5.

AUTORES / AUTHORS:  - Hatano H; Ogawa I; Shigeishi H; Kudo Y; Ohta K; Higashikawa K; Takechi M; Takata T; Kamata N

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

RESUMEN / SUMMARY:  - Fibro-osseous lesions of the jaw are poorly understood because of a significant overlap of clinical, radiological and histological features among the various types, though they present distinct patterns of disease progression. An ossifying fibroma is associated with significant cosmetic and functional disturbances, as it shows expansive proliferation. Thus, it is important to establish a specific marker, as well as clearly elucidate its etiology for diagnosis and proper treatment. We previously established immortalized cell lines from human ossifying fibromas of the jaw and found that they highly expressed the receptor for hyaluronan (HA)-mediated motility (RHAMM). In this study, we examined the expression of RHAMM mRNA in 65 fibro-osseous lesions, including ossifying fibroma, fibrous dysplasia and osseous dysplasia, as well as 5 normal jaws, using real-time RT-PCR and immunohistochemistry assays. RHAMM mRNA and protein expression were significantly elevated in the ossifying fibroma specimens. These  results suggest that detection of upregulated RHAMM expression in an ossifying fibroma assists with differential diagnosis and has a key role in elucidation of  its pathophysiology.

 

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[189]

TÍTULO / TITLE:  - MRI Assessment of Uterine Artery Patency and Fibroid Infarction Rates 6 Months after Uterine Artery Embolization with Nonspherical Polyvinyl Alcohol.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cardiovasc Intervent Radiol. 2013 Feb 6.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00270-013-0561-y

AUTORES / AUTHORS:  - Das R; Gonsalves M; Vlahos I; Manyonda I; Belli AM

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, St George’s Healthcare NHS Trust, Blackshaw, London, SW17 0QT, UK, rajdas@nhs.net.

RESUMEN / SUMMARY:  - PURPOSE: We have observed significant rates of uterine artery patency after uterine artery embolization (UAE) with nonspherical polyvinyl alcohol (nsPVA) on  6 month follow-up MR scanning. The study aim was to quantitatively assess uterine artery patency after UAE with nsPVA and to assess the effect of continued uterine artery patency on outcomes. METHODS: A single centre, retrospective study of 50 patients undergoing bilateral UAE for uterine leiomyomata was undertaken. Pelvic  MRI was performed before and 6 months after UAE. All embolizations were performed with nsPVA. Outcome measures included uterine artery patency, uterine and dominant fibroid volume, dominant fibroid percentage infarction, presence of ovarian arterial collaterals, and symptom scores assessed by the Uterine Fibroid  Symptom and Quality of Life questionnaire (UFS-QOL). RESULTS: Magnetic resonance  angiographic evidence of uterine artery recanalization was demonstrated in 90 % of the patients (64 % bilateral, 26 % unilateral) at 6 months. Eighty percent of  all dominant fibroids demonstrated >90 % infarction. The mean percentage reduction in dominant fibroid volume was 35 %. No significant difference was identified between nonpatent, unilateral, and bilateral recanalization of the uterine arteries with regard to percentage dominant fibroid infarction or dominant fibroid volume reduction. The presence of bilaterally or unilaterally patent uterine arteries was not associated with inferior clinical outcomes (symptom score or UFS-QOL scores) at 6 months. CONCLUSION: The high rates of uterine artery patency challenge the current paradigm that nsPVA is a permanent embolic agent and that permanent uterine artery occlusion is necessary to optimally treat uterine fibroids. Despite high rates of uterine artery recanalization in this cohort, satisfactory fibroid infarction rates and UFS-QOL  scores were achieved.

 

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[190]

TÍTULO / TITLE:  - Management of intravascular leiomyomatosis: Laparoscopic surgery for ordinary uterine fibroids led to an extraordinary finding.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Obstet Gynecol. 2013 Apr;208(4):333.e1-2. doi: 10.1016/j.ajog.2013.02.044. Epub 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ajog.2013.02.044

AUTORES / AUTHORS:  - Lakhi N; Serur E; Chi DS

INSTITUCIÓN / INSTITUTION:  - Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York. Electronic address: nlakhi@yahoo.com.

RESUMEN / SUMMARY:  - An unexpected diagnosis of intravascular leiomyomatosis was made during a laparoscopic procedure. As the extent of the disease was unknown, the initial procedure was limited to laparoscopic hysterectomy and salpingo-oophorectomy. Postoperative computed tomography imaging demonstrated intravascular leiomyomatosis extending into the suprarenal inferior vena cava. The patient underwent exploratory laparotomy to excise residual tumor.

 

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[191]

TÍTULO / TITLE:  - Lymphangioleiomyomatosis Screening in Women with Tuberous Sclerosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chest. 2013 Mar 28. doi: 10.1378/chest.12-2813.

            ●● Enlace al texto completo (gratuito o de pago) 1378/chest.12-2813

AUTORES / AUTHORS:  - Cudzilo CJ; Szczesniak RD; Brody AS; Rattan M; Krueger DA; Bissler JJ; Franz DN; McCormack FX; Young LR

RESUMEN / SUMMARY:  - ABSTRACT BACKGROUND: Lymphangioleiomyomatosis (LAM) occurs in at least 40% of women with Tuberous Sclerosis Complex (TSC), as diagnosed based on chest CT scan  findings. Early identification may inform life style choices and treatment decisions. Here we report LAM prevalence in a large TSC Clinic and propose an approach to CT screening for LAM in women with TSC. METHODS: We retrospectively reviewed initial chest CT scans of all female TSC patients age >/=15 years seen at our center over a 12-year period. Each CT image slice was manually scored for  the presence or absence of cysts, and the diagnosis of LAM was made if at least four characteristic thin-walled cysts were present. RESULTS: Of 133 female TSC patients, 101 had chest CT scans available for review. 48 (47.5%) met criteria for TSC-LAM on the initial CT scan. The risk of LAM was age-dependent, rising by  about 8% per year. The prevalence of LAM was 27% in subjects &lt;21 years and 81% in subjects &gt;40 years. Among asymptomatic subjects with LAM, 84% had cysts present in the single image at level of the carina. Most subjects with LAM eventually developed pulmonary symptoms (63%), and 12.5% died due to LAM. CONCLUSIONS: These results suggest that most women with TSC ultimately develop cystic changes consistent with LAM, and that most cases can be identified from a  single CT slice at the level of the carina. TSC-LAM was associated with appreciable morbidity and mortality in our referral population. An age-based approach using limited CT scanning methods may facilitate screening and subsequent treatment decisions with decreased radiation exposure in this at-risk  population.

 

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[192]

TÍTULO / TITLE:  - Solitary fibrous tumors of the thorax: nomenclature, epidemiology, radiologic and pathologic findings, differential diagnoses, and management.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - AJR Am J Roentgenol. 2013 Mar;200(3):W238-48. doi: 10.2214/AJR.11.8430.

            ●● Enlace al texto completo (gratuito o de pago) 2214/AJR.11.8430

AUTORES / AUTHORS:  - Chick JF; Chauhan NR; Madan R

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic Radiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

 

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[193]

TÍTULO / TITLE:  - Inflammatory Myofibroblastic Tumor of the Kidney.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Urol. 2013 Mar 15. pii: S0022-5347(13)03682-3. doi: 10.1016/j.juro.2013.03.036.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.juro.2013.03.036

AUTORES / AUTHORS:  - Jenkins LC; Whittington E; Ciancio G; Jorda M

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Transplant Institute, Jackson Memorial Hospital, Miami, Florida.

 

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[194]

TÍTULO / TITLE:  - Leiomyosarcoma of the Epididymis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Urol. 2013 Feb 26. pii: S0022-5347(13)00358-3. doi: 10.1016/j.juro.2013.02.082.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.juro.2013.02.082

AUTORES / AUTHORS:  - Humphrey PA

INSTITUCIÓN / INSTITUTION:  - Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.

 

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[195]

TÍTULO / TITLE:  - Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Jun;30(2):499. doi: 10.1007/s12032-013-0499-6. Epub 2013 Feb 22.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-013-0499-6

AUTORES / AUTHORS:  - Cai H; Lin L; Cai H; Tang M; Wang Z

INSTITUCIÓN / INSTITUTION:  - Pediatric Orthopedic Department, Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200031, China.

RESUMEN / SUMMARY:  - MicroRNA-210 (miR-210) plays important roles in the regulation of cell growth, angiogenesis, and apoptosis in different cancer type. Previous study of miRNA expression profiling found that miR-210 was significantly elevated in osteosarcoma samples. However, its roles in this disease have not been fully elucidated. Thus, the aim of this study was to investigate the association of miR-210 expression with clinicopathologic features and prognosis in patients with osteosarcomas. Quantitative real-time reverse transcriptase-polymerase chain reaction analysis was performed to detect the expression level of miR-210 in cancerous and noncancerous bone tissues from 92 children treated for primary osteosarcomas. MiR-210 expression was significantly increased in osteosarcoma tissues compared with that in corresponding noncancerous bone tissues (P < 0.001). In addition, miR-210 upregulation more frequently occurred in osteosarcoma tissues with large tumor size (P = 0.02), poor response to preoperative chemotherapy (P = 0.008), and positive metastasis (P = 0.01). Moreover, miR-210 upregulation was associated with significantly decreased overall survival (P = 0.007) and progression-free survival (P = 0.01). In the Cox proportional hazard model, it was confirmed that its expression in the biopsy samples was an independent prognostic factor of unfavorable survival in osteosarcoma (for overall survival: P = 0.01; for progression-free survival: P =  0.02). These findings suggested that miR-210 upregulation showed a strong correlation with tumor aggressive progression of pediatric osteosarcoma and could help prognostic screening of patients with this malignancy.

 

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[196]

TÍTULO / TITLE:  - Low-grade central osteosarcoma arising from bone infarct.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Jan 31. pii: S0046-8177(12)00439-X. doi: 10.1016/j.humpath.2012.11.011.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.11.011

AUTORES / AUTHORS:  - Endo M; Yoshida T; Yamamoto H; Ishii T; Setsu N; Kohashi K; Matsunobu T; Iwamoto Y; Oda Y

INSTITUCIÓN / INSTITUTION:  - Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 812-8582.

RESUMEN / SUMMARY:  - Bone infarct-associated sarcoma is a rare sarcoma, accounting for less than 1% of all bone sarcomas. Its histology usually reflects a high-grade sarcoma, such as malignant fibrous histiocytoma of bone or conventional osteosarcoma. Low-grade sarcoma arising from bone infarct has not been described well in the literature.  Here, we present a 17-year follow-up of a female patient with bone infarct in her right humerus, from which a low-grade central osteosarcoma developed during follow-up. A histologic diagnosis of low-grade central osteosarcoma was confirmed by immunohistochemical expression of MDM2 and CDK4. She underwent a wide resection surgery. As of 4 years after surgery, she has remained free of any evidence of recurrence or metastasis. Here, we present clinical and pathologic findings of our case in detail and discuss the differential diagnoses of this extremely rare condition.

 

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[197]

TÍTULO / TITLE:  - Prognostic indicators in WHO 2003 low-grade endometrial stromal sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Histopathology. 2013 Apr;62(5):675-87. doi: 10.1111/j.1365-2559.2011.04115.x. Epub 2013 Feb 21.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1365-2559.2011.04115.x

AUTORES / AUTHORS:  - Feng W; Hua K; Gudlaugsson E; Yu Y; Zhou X; Baak JP

INSTITUCIÓN / INSTITUTION:  - Department of Gynaecology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China Department of Pathology, Stavanger University Hospital, Stavanger Clinicla Institute-1, University in Bergen, Bergen, Norway Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX,  USA Department of Pathology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.

RESUMEN / SUMMARY:  - Aims: Endometrial stromal sarcoma (ESS) has traditionally been divided into low and high grade, but the World Health Organization (WHO, 2003) has changed the definition. Since 2003, many studies have used the old criteria, and few have focused on WHO 2003-defined ESS low grade (ESS-LG). The aim of this study was to  investigate prognosticators in ESS-LG. Methods and results: We reviewed the WHO 2003 diagnostic criteria in 91 tumours (previously classified as ESS low and high grade). There were 68 cases of ESS-LG and 23 of undifferentiated endometrial sarcoma (UES). In the ESS-LG cases, the prognostic value of clinicopathological variables was studied. With a median follow-up of 79 months (range: 20-474 months), the recurrence and death rates were 5/68 (7%) and 1/68 (1.5%) in the ESS-LG cases. Ovarian preservation or no ovarian preservation (P < 0.0001, hazard ratio (HR) 10.4) and mitotic activity index (MAI) (0-3 versus >3, P = 0.005, HR 8.6) had independent prognostic value. Other frequently used MAI thresholds - age, tumour diameter, and vessel invasion - were not prognostic. Among patients without ovarian preservation (n = 61), none of 53 with MAI 0-3 suffered recurrence, contrasting with two of eight (25%) of those with MAI >3 (P = 0.003); one of these two recurrence patients died (P = 0.02). Among patients with ovarian preservation (n = 7), three (43%) suffered recurrence but none died, and MAI had  no additional prognostic value. Conclusions: In ESS-LG, ovarian preservation and  MAI >3 are associated with increased risk of recurrence.

 

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[198]

TÍTULO / TITLE:  - AIRP Best Cases in Radiologic-Pathologic Correlation: Alveolar Soft-Part Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Radiographics. 2013 Mar;33(2):585-93. doi: 10.1148/rg.332115173.

            ●● Enlace al texto completo (gratuito o de pago) 1148/rg.332115173

AUTORES / AUTHORS:  - Itani M; Shabb NS; Haidar R; Khoury NJ

INSTITUCIÓN / INSTITUTION:  - Departments of Diagnostic Radiology, Pathology and Laboratory Medicine, and Surgery, American University of Beirut Medical Center, Riad El-Solh, Beirut, Lebanon 1107-2020.

 

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[199]

TÍTULO / TITLE:  - Response to commentary on ‘Angiosarcoma as a Potential Consequence of Autologous  Lymph Node Transplantation for Lymphoedema’

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Vasc Endovasc Surg. 2013 Mar 2. pii: S1078-5884(13)00084-1. doi: 10.1016/j.ejvs.2013.01.035.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejvs.2013.01.035

AUTORES / AUTHORS:  - Vignes S

INSTITUCIÓN / INSTITUTION:  - Unite de Lymphologie, Hopital Cognacq-Jay, 15 rue Eugene Millon, 75015 Paris, France. Electronic address: stephane.vignes@cognacq-jay.fr.

 

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[200]

TÍTULO / TITLE:  - Angiosarcoma as a Potential Consequence of Autologous Lymph Node Transplantation  for Lymphoedema.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Vasc Endovasc Surg. 2013 Mar 1. pii: S1078-5884(13)00085-3. doi: 10.1016/j.ejvs.2013.01.036.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejvs.2013.01.036

AUTORES / AUTHORS:  - Samimi M; Maruani A; Vaillant L; Lorette G

INSTITUCIÓN / INSTITUTION:  - Dermatology Department, Universite Francois Rabelais, University Hospital of Tours, France; INRA ISP, UMR 1282, Tours, Universite Francois Rabelais, Tours, France. Electronic address: samimi.mahtab@yahoo.fr.

 

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[201]

TÍTULO / TITLE:  - The expression and characterization of endoglin in uterine leiomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Exp Metastasis. 2013 Feb 9.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10585-013-9574-9

AUTORES / AUTHORS:  - Mitsui H; Shibata K; Mano Y; Suzuki S; Umezu T; Mizuno M; Yamamoto E; Kajiyama H; Kotani T; Senga T; Kikkawa F

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya, 466-8550, Japan.

RESUMEN / SUMMARY:  - Endoglin (CD105), an accessory receptor of transforming growth factor-beta, is expressed in vascular endothelial cells. Recently, it was reported that endoglin  expression was significantly associated with poorer survival in several cancers.  In this study, we evaluated the role of endoglin in uterine leiomyosarcoma. We examined the expression of endoglin in 22 uterine leiomyosarcomas and the association between their expression and the outcome. Additionally, to evaluate the function of endoglin, we used SKN cells, a human uterine leiomyosarcoma cell  line. We generated SKN cells stably transfected with plasmids encompassing shRNA  targeting endoglin (shEng cells), and compared the ability of proliferation, migration, and invasion to control shRNA-transfected cells (shCon cells). We compared the level of VEGF and matrix metalloproteinases (MMP) in culture supernatants of shEndoglin and shControl cells. Nine patients were endoglin-positive and 13 patients were -negative. The endoglin-positive group had a significantly poorer overall survival and progression-free survival than the endoglin-negative group. In an in vitro study, there was no difference in cell proliferation between shEng and shCon cells. On the other hand, shEng cells showed a lower ability for migration and invasion than shControl cells. The activity of MMP-9 and VEGF level in the supernatant from shEng cells were lower than in shCon cells. In uterine leiomyosarcoma, endoglin expression was associated with a poor prognosis. It was suggested that endoglin up-regulated invasion and VEGF secretion. The investigation of endoglin may lead to a new strategy in uterine leiomyosarcoma therapy.

 

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[202]

TÍTULO / TITLE:  - ERCP with intracholedocal biopsy for the diagnosis of biliary tract rhabdomyosarcoma in children.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Surg Int. 2013 Feb 17.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00383-013-3282-z

AUTORES / AUTHORS:  - Scottoni F; De Angelis P; Dall’oglio L; Francalanci P; Monti L; de Ville de Goyet J

INSTITUCIÓN / INSTITUTION:  - Hepatobiliopancreatic Surgery Unit, Department of Pediatric Surgery and Transplantation, Bambino Gesu Children’s Hospital, IRCCS, Piazza San Onofrio 4, 00165, Rome, Italy, fscottoni@msn.com.

RESUMEN / SUMMARY:  - Rhabdomyosarcoma is the most common tumor of the biliary tract in children. Although some features at preoperative radiographic studies (ultrasound, CT, MRI) may be suggestive of BT-RMS, until few years ago the final diagnosis was obtained by either operative or transcutaneous biopsy, thus exposing to a risk of regional dissemination. More recent and still anecdotal, is the histological diagnosis on  tissue obtained by transluminal biopsy either during transhepatic cholangiography or endoscopic retrograde cholangio-pancreatography (ERCP), the latter having the  major advantage of a much lower risk of loco-regional dissemination. We present two cases of BT-RMS that were histologically diagnosed by intracholedocal biopsy  performed during ERCP, after being suspected at conventional imaging.

 

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[203]

TÍTULO / TITLE:  - Aggressive locoregional management of recurrent peritoneal sarcomatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Surg Oncol. 2013 Mar;107(4):329-34. doi: 10.1002/jso.23232. Epub 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jso.23232

AUTORES / AUTHORS:  - Baumgartner JM; Ahrendt SA; Pingpank JF; Holtzman MP; Ramalingam L; Jones HL; Zureikat AH; Zeh HJ 3rd; Bartlett DL; Choudry HA

INSTITUCIÓN / INSTITUTION:  - Division of Surgical Oncology, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

RESUMEN / SUMMARY:  - BACKGROUND AND OBJECTIVES: Peritoneal sarcomatosis responds poorly to systemic chemotherapy and demonstrates high rates of recurrence after resection. We sought to determine perioperative and oncologic outcomes after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) for recurrent sarcomatosis. METHODS: We reviewed 15 patients undergoing 17 CRS/HIPEC for recurrent sarcomatosis from a prospective database. RESULTS: There were four synovial cell sarcomas, five liposarcomas, three leiomyosarcomas, two gastrointestinal stromal tumors (GIST), and three other sarcomas. Adequate cytoreduction (CC-0/1) was achieved in all patients, with a median intra-operative Simplified Peritoneal Carcinomatosis Index of 6 (range: 3-9). Median blood loss and operative time were 1 L (range: 450-5,200) and 402 min (range: 324-680), respectively. Chemoperfusion drug was mitomycin C, cisplatin, or doxorubicin. Significant post-operative complications (Clavien-Dindo III/IV) occurred in four (24%) patients, with no 60-day mortalities and three (18%) 60-day re-admissions. Median intra-abdominal disease-free and overall survival after CRS/HIPEC was 17.2 (95% CI: 2.4-19.7 months) and 22.6 months (95% CI: 6.1-62.6 months), respectively. There was a trend towards delayed recurrence after combined CRS/HIPEC than after prior CRS alone (17.2 months vs. 10.7 months, respectively; P = 0.52). CONCLUSION: Cytoreduction combined with HIPEC may improve loco-regional disease control in patients with recurrent sarcomatosis.

 

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[204]

TÍTULO / TITLE:  - Primary Cutaneous Osteosarcoma of the Skin: A Report of 2 Cases With Emphasis on  the Differential Diagnoses.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Dermatopathol. 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1097/DAD.0b013e31827f0a6f

AUTORES / AUTHORS:  - Llamas-Velasco M; Rutten A; Requena L; Mentzel T

INSTITUCIÓN / INSTITUTION:  - *Instituto de Investigacion Sanitaria De La Princesa, Madrid, España daggerDermatopathologie Bodensee, Friedrichshafen, Germany double daggerDepartment of Dermatology, Fundacion Jimenez Diaz, Madrid, España.

RESUMEN / SUMMARY:  - : Dermal or subcutaneous involvement of extraskeletal osteosarcoma is uncommon, and primary cutaneous osteosarcoma of the skin is even rarer, with only few cases well characterized. The authors present 2 cases of this infrequent skin neoplasm. A 76-year-old woman with a nodule on left malar area and an 82-year-old man with  a hard nodule on the right temple. First patient’s biopsy findings were a dermal  lesion mostly composed of malignant osteoid material, with atypical rhabdoid cells intermingled, which was diagnostic of osteoblastic osteosarcoma. Excision of the lesion of the second patient showed a dermal proliferation of atypical spindle-shaped and pleomorphic cells, scattered multinucleated osteoclasts-like cells, and irregular malignant osteoid material. In some fields, atypical cells showed a pseudovascular pattern. Close to this exophytic lesion, a small nest of  basal cell carcinoma was observed. Final diagnosis was collision of osteoblastic  and telangiectatic primary osteosarcoma and superficial basal cell carcinoma. Both patients have not presented recurrence or metastatic disease after 12 and 9  months of follow-up, respectively. Clinical and histopathologic characteristics of the primary cutaneous osteosarcoma are summarized, and the differential diagnosis of this entity with other benign and malignant skin neoplasms, which can, eventually, show osteoid material.

 

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[205]

TÍTULO / TITLE:  - Tumor size increase following preoperative radiation of soft tissue sarcomas does not affect prognosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Surg Oncol. 2013 Feb 11. doi: 10.1002/jso.23322.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jso.23322

AUTORES / AUTHORS:  - Delisca GO; Alamanda VK; Archer KR; Song Y; Schwartz HS; Holt GE

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee.

RESUMEN / SUMMARY:  - BACKGROUND AND OBJECTIVES: Administration of preoperative radiotherapy for extremity soft tissue sarcoma improves local control, while allowing for a more conservative surgical resection. During radiation treatment tumor size typically  decreases or remains constant. In a subset of patients, however, a size increase  in the tumor occurs. Our goal was to investigate the prognosis of patients who had a size increase of at least 20% over the course of preoperative radiotherapy  versus those who did not. METHODS: This retrospective study evaluated 70 patients treated for localized primary STS of the extremities between January 2000 and December 2008. Kaplan-Meier curves for disease-specific and metastasis-free survival were calculated for both groups. RESULTS: Sixty-one patients had stable  or decrease local tumor size following preoperative radiotherapy and nine patients had an increase of at least 20% in tumor size. There were no statistically significant differences found in disease-specific survival and metastasis-free survival (Gray’s test, P = 0.93 and P = 0.68, respectively) among the two groups. CONCLUSION: Our results indicate that a 20% increase in tumor size following preoperative radiotherapy did not result in a worse outcome for patients when compared to those who had stable or decrease local tumor size following preoperative radiotherapy. J. Surg. Oncol © 2013 Wiley Periodicals, Inc.

 

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[206]

TÍTULO / TITLE:  - Angiosarcoma Outcomes and Prognostic Factors: A 25-Year Single Institution Experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Clin Oncol. 2013 Feb 20.

            ●● Enlace al texto completo (gratuito o de pago) 1097/COC.0b013e31827e4e7b

AUTORES / AUTHORS:  - Buehler D; Rice SR; Moody JS; Rush P; Hafez GR; Attia S; Longley BJ; Kozak KR

INSTITUCIÓN / INSTITUTION:  - Departments of *Pathology daggerHuman Oncology section signMedicine parallelDermatology, University of Wisconsin, School of Medicine and Public Health, Madison, WI double daggerMoses Cone Regional Cancer Center, Greensboro, NC.

RESUMEN / SUMMARY:  - OBJECTIVE:: Angiosarcoma is an aggressive malignancy with endothelial differentiation and notoriously poor prognosis despite aggressive therapy. Limited data are available to guide management decisions. To address this limitation, we present a large retrospective analysis of angiosarcoma patients treated at a single institution over a 25-year period. METHODS:: To identify factors that impact angiosarcoma outcomes, we reviewed demographic, tumor, and treatment characteristics of angiosarcoma patients evaluated at the University of Wisconsin Hospital between 1987 and 2012. RESULTS:: The cohort included 81 patients diagnosed at ages 19 to 90 years (median, 67 y). Fifty-five (68%) patients presented with localized disease, whereas 26 (32%) presented with metastases. The primary sites were visceral/deep soft tissue (42%), head and neck/cutaneous (37%), breast (16%), and limbs in the setting of Stewart-Treves (5%). The 5-year overall survival was 40% with a median of 16 months. By univariate analysis, significant adverse predictors of survival included metastases at presentation, visceral/deep soft tissue tumor location, tumor size>5 cm, tumor necrosis, and the absence of surgical excision. A trend toward prolonged survival was observed with radiation therapy and for chemotherapy in patients with metastases. Age, sex, and prior radiation showed no correlation with survival. CONCLUSIONS:: Our large single institution series confirms the poor prognosis of angiosarcoma, supports a central role for surgical excision in  management, and highlights the need for novel therapies particularly in patients  who present with metastatic disease.

 

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[207]

TÍTULO / TITLE:  - Juvenile nasopharyngeal angiofibroma: A Systematic Review and Comparison of Endoscopic, Endoscopic-Assisted, and Open Resection in 1047 Cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Laryngoscope. 2013 Apr;123(4):859-69. doi: 10.1002/lary.23843. Epub 2013 Mar 11.

            ●● Enlace al texto completo (gratuito o de pago) 1002/lary.23843

AUTORES / AUTHORS:  - Boghani Z; Husain Q; Kanumuri VV; Khan MN; Sangvhi S; Liu JK; Eloy JA

INSTITUCIÓN / INSTITUTION:  - Department of Neurological Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, U.S.A.

RESUMEN / SUMMARY:  - OBJECTIVES/HYPOTHESIS: This study is a review of the treatment outcomes of juvenile nasopharyngeal angiofibroma (JNA) specifically comparing endoscopic, endoscopic-assisted, and open surgical approaches. STUDY DESIGN: Systematic review of studies using the MEDLINE database. METHODS: A systematic review of studies on JNA from 1990 to 2012 was conducted. A search for articles related to  JNA, along with bibliographies of those articles, was performed. Articles were examined for individual patient data (IPD) and aggregate patient data (APD). Demographics, presenting symptoms, surgical approach, follow-up, and outcome were analyzed. RESULTS: Eighty-five articles were included, with IPD reported in 57 articles (345 cases) and APD in 28 articles (702 cases). For the IPD cohort, average follow-up was 33.4 months (range, 0.5-264 months). Average blood loss was 544.0 mL, 490.0 mL, and 1579.5 mL for endoscopic, endoscopic-assisted, and open surgical cases, respectively (P < .05). Recurrence rate following endoscopic surgery and open surgery were significantly less than endoscopic-assisted surgery (P < .05). In the APD cohort, the recurrence rate following endoscopic surgery was 4.7% compared to 20.6% in the endoscopic-assisted group and 22.6% in the open surgery group (P < .05). Among studies that reported Radkowski/Sessions grading,  there was no significant difference in recurrence rates for both the IPD and APD  cohorts across each stage between open and endoscopic surgery (P > .05). CONCLUSIONS: In this study, endoscopic resection had a significantly lower intraoperative blood loss and lower recurrence rate when compared to open resection. However, there was no difference in recurrence rate when analyzing the IPD and controlling for Radkowski/Sessions grading. Therefore, further large-scale studies may be required to fully elucidate treatment options.

 

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[208]

TÍTULO / TITLE:  - Dermatofibrosarcoma Protuberans in an Adolescent: A Case Report and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Hematol Oncol. 2013 Mar 21.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MPH.0b013e3182843edc

AUTORES / AUTHORS:  - Manganoni AM; Pavoni L; Gualdi G; Marocolo D; Chiudinelli M; Sereni E; Farisoglio C; Calzavara-Pinton P

INSTITUCIÓN / INSTITUTION:  - Departments of *Dermatology daggerPathology I, University Hospital Spedali Civili, Brescia, Italy.

RESUMEN / SUMMARY:  - Classically, dermatofibrosarcoma protuberans (DFSP) is a disease of adults. The world literature revision shows that several pediatric cases have been reported so far; this might suggest that the number of infants with the condition might be larger than that estimated previously. Here, we report the 183rd case of histologically confirmed DFSP in young age. A 14-year-old white male patient came under our care for a slowly growing, pale brownish lesion on the neck skin. A biopsy specimen showed a DFSP. Subsequently, a wide surgery excision with 3 cm of resection margins including the underlying fascia was performed. To date, the patient has been in follow-up for 6 years without evidence of recurrent disease.  The clinical features and treatment of DFSP diagnosed in childhood and adolescence reported in the published literature are reviewed to provide new insights about this rare entity. The aim is to emphasize the importance of biopsy for histologic evaluation in the cases that show a persistent or a large cutaneous plaque or nodule without pathognomonic clinical features that permit a  clinical diagnosis. An accurate knowledge of the disease is the prerequisite for  a wider recognition and appropriate treatment.

 

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[209]

TÍTULO / TITLE:  - Systemic mastocytosis presenting as intraoperative anaphylaxis with atypical features: a report of two cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anaesth Intensive Care. 2013 Jan;41(1):116-21.

AUTORES / AUTHORS:  - Bridgman DE; Clarke R; Sadleir PH; Stedmon JJ; Platt P

INSTITUCIÓN / INSTITUTION:  - Department of Anaesthesia, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

RESUMEN / SUMMARY:  - Two cases of perioperative cardiovascular collapse are presented that were associated with markedly elevated mast cell tryptase levels shortly after the event, leading to the assumption that an immunoglobin E-mediated, drug-induced anaphylaxis had occurred. However, the clinical picture in both cases was atypical and subsequent skin testing failed to identify a triggering drug. Further blood tests, some weeks later, revealed persistently elevated baseline levels of mast cell tryptase. In both cases bone marrow biopsy and genetic testing confirmed the diagnosis of mastocytosis. We present evidence and speculate that mast cell degranulation was triggered by tourniquet release in the first case and by exposure to peanuts in the second. An atypical presentation of  anaphylaxis should alert the anaesthetist to the possibility of previously undiagnosed mastocytosis.

 

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[210]

TÍTULO / TITLE:  - Local control and sequelae in localised Ewing tumours of the spine: A French retrospective study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cancer. 2013 Apr;49(6):1314-23. doi: 10.1016/j.ejca.2012.12.005. Epub 2013  Feb 8.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejca.2012.12.005

AUTORES / AUTHORS:  - Vogin G; Helfre S; Glorion C; Mosseri V; Mascard E; Oberlin O; Gaspar N

INSTITUCIÓN / INSTITUTION:  - Departement de Radiotherapie, Centre Alexis Vautrin, Nancy, France.

RESUMEN / SUMMARY:  - OBJECTIVES: To evaluate both local outcome and sequelae of non-metastatic spinal  Ewing tumours (EWT). PATIENTS AND METHODS: A French cohort of patients 50years with localised spinal EWT treated between 1988 and 2009, was analysed in regard to tumour characteristics (e.g. volume, vertebral compartment, spinal cord compression, paraspinal soft tissue invasion), local treatment modalities (surgery (S) and margin quality, radiotherapy (RT) dose), response to treatment (e.g. histological response to neoadjuvant chemotherapy (CT)), tumour local control (LC) and sequelae. RESULTS: Seventy-five patients treated in successive trials were evaluated for LC: SFOP-EW88 (n=14), SFOP-EW93 (n=17) and EuroEwing99  (n=44). Fifty-seven patients (79%) presented initial neurological compression and 69% had inaugural decompressive S. Local treatment modality was S+RT (n=50), RT alone (n=19) and S alone (n=6). Surgery was mainly intralesional (66%). Local recurrences had occurred in 19patients (14 local, 5 loco-regional) with a median  interval of 25months (1-50). After a 7year median follow-up (1-22years), the 5-year LC, relapse-free survival (RFS) and overall survival (OS) reached 78.0% (95%CI: 62.6-84.6), 57.0% (95%CI: 45.2-68.9) and 70.0% (95%CI: 59.1-81.0), respectively. Vertebral compartment involved was the only prognostic factor (5-year LC rate 100% versus 71% for favourable and unfavourable compartment, p<0.03). Among 41 five-year survivors, we observed spinal curvature deformation (35%), growth retardation (28%), spinal reduction mobility (40%), spinal pain (25%) and neurological sequelae (32%) without any significant association with a  particular local procedure. CONCLUSION: RT is the backbone of a successful local  treatment of spinal EWT. The place of S remains a pending question. Its actual benefit will likely evolve with new available RT techniques.

 

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[211]

TÍTULO / TITLE:  - Association Between Esophageal Leiomyomatosis and p53 Mutation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Surg. 2013 Apr;95(4):1429-31. doi: 10.1016/j.athoracsur.2012.08.081.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.athoracsur.2012.08.081

AUTORES / AUTHORS:  - Kazarin O; Vlodavsky E; Guralnik L; Kremer R; Lachter J; Bar-Sela G

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, Rambam Health Care Campus and Technion-Israel Institute of Technology, Haifa, Israel.

RESUMEN / SUMMARY:  - Li-Fraumeni syndrome is a cancer predisposition syndrome associated with a variety of neoplasms, mainly soft tissue sarcoma, premenopausal breast cancer, brain tumors, adrenocortical carcinoma, and leukemia. Esophageal leiomyomatosis involves the presence of several rare benign neoplastic lesions composed of proliferating smooth muscle cells in the esophageal wall. The current case report presents a patient with recurrent diffuse leiomyomas of the esophagus and confirmed p53 mutation with clinical criteria of Li-Fraumenilike syndrome.

 

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[212]

TÍTULO / TITLE:  - A Case of Atypical Fibrous Histiocytoma with Positivity for CD163 and CD44.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Derm Venereol. 2013 Mar 5. doi: 10.2340/00015555-1563.

            ●● Enlace al texto completo (gratuito o de pago) 2340/00015555-1563

AUTORES / AUTHORS:  - Tsunoda K; Takahashi K; Maeda F; Oikawa H; Akasaka T

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, School of Medicine, Iwate Medical University, Uchimaru 19-1, Morioka 020-8505, Japan. ktakami@iwate-med.ac.jp.

RESUMEN / SUMMARY:  - Abstract is missing (Letter).

 

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[213]

TÍTULO / TITLE:  - Plexiform neurofibroma affecting the upper parietal scalp, with cerebellar hamartoma: role of histopathology, colour Doppler imaging and magnetic resonance  imaging.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Exp Dermatol. 2013 Apr;38(3):285-8. doi: 10.1111/ced.12027.

            ●● Enlace al texto completo (gratuito o de pago) 1111/ced.12027

AUTORES / AUTHORS:  - Sehgal VN; Oberai R; Venkatash P; Sharma S; Verma P; Chatterji K

INSTITUCIÓN / INSTITUTION:  - Dermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, New Delhi, India.

RESUMEN / SUMMARY:  - We report a patient with plexiform neurofibroma, which is pathognomonic for neurofibromatosis type 1 (NF1) affecting the upper parietal region of the scalp.  Cerebellar hamartoma was present, a finding that, to our knowledge, has not been  reported previously. We highlight the role of histopathology, ultrasonography, colour Doppler imaging and magnetic resonance imaging, in addition to the seven existing criteria, for the diagnosis of NF1.

 

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[214]

TÍTULO / TITLE:  - Fine needle aspiration diagnosis of a spontaneously infarcted fibroadenoma mimicking carcinoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anal Quant Cytol Histol. 2013 Feb;35(1):57-60.

AUTORES / AUTHORS:  - Arora R; Abou-Bakr A; Al Taleb A

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Farwaniya Hospital, P.O. Box 18373, Farwaniya 81004, Kuwait. arorarajan73@rediffmail.com

RESUMEN / SUMMARY:  - BACKGROUND: Spontaneous infarction of fibroadenoma is an extremely rare complication in a nonpregnant/nonlactating female undergoing first-time aspiration. It can be misdiagnosed as carcinoma in all aspects of triple approach used for evaluation of patients with breast lesions. CASE: A 37-year-old woman presented to the outpatient surgical clinic with a 6-month history of a breast lump that was slowly increasing in size and had become painful during the past month. There was no history of any trauma or fine needle aspiration, and she was  not pregnant or lactating. Mammogram and ultrasound revealed a 2.9-cm heterogenous hypoechoic suspicious lesion. No lymph nodes were detected in the axilla. Fine needle aspiration cytology was performed, and a diagnosis of benign  breast lesion with features of infarction was rendered on cytology. The lump was  excised surgically, and a histological diagnosis of infarcted fibroadenoma was made. CONCLUSION: Careful and diligent search for preserved benign epithelial cells on smears is the key to recognize this entity and avoid serious therapeutic implications.

 

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[215]

TÍTULO / TITLE:  - Laparoscopic aspiration for central renal angiomyolipoma: a novel technique based on single-center initial experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Urology. 2013 Feb;81(2):313-8. doi: 10.1016/j.urology.2012.09.047.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.urology.2012.09.047

AUTORES / AUTHORS:  - Xu B; Zhang Q; Jin J

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, National Urological Cancer Center, Xicheng District, Beijing,  China.

RESUMEN / SUMMARY:  - OBJECTIVE: To report on the novel technique of laparoscopic aspiration for central renal angiomyolipoma (RAML) in a series of patients treated in our institution and summarize our single-center initial experience. METHODS: We retrospectively reviewed the clinical data of 10 patients (4 men and 6 women) with pathologically confirmed central RAML who underwent laparoscopic aspiration  between August 2010 and May 2012. Indications for surgical intervention included  8 (80%) tumors of >4 cm and 2 (20%) symptomatic RAMLs. Patient demographics, intraoperative variables, and postoperative outcomes were reported and analyzed.  Follow-up was performed by serum creatinine and imaging techniques. RESULTS: All  patients were diagnosed with sporadic central RAML. None was affected by tuberous sclerosis. All operations were performed successfully by laparoscopic aspiration  without conversion to partial nephrectomy, enucleation, or even open surgery. One complication of perirenal fluid collection occurred but finally recovered only with conservative treatment. No other complication or transfusion was observed. The mean tumor size was 5.1 cm (range 3.2-7.7 cm). The mean operative time was 92.1 minutes (range 67-140). The mean warm ischemia time was 27.5 minutes (range  20-30). The mean estimated blood loss was 53.5 mL (range 10-150). The mean retroperitoneal drainage was 2.3 days (range 1-3). The mean postoperative hospital stay was 4.3 days (range 3-8). The level of serum creatinine were all within normal limits with mean preoperative and postoperative 0.85 mg/dL (range 0.55-1.07) and 1.11 mg/dL (range 0.71-1.26), respectively. No recurrence or new lesions occurred in these patients at a mean follow-up of 7.7 months. CONCLUSION: Our initial experience suggests that the novel technique of laparoscopic aspiration is a feasible, safe, and effective minimally invasive procedure for the treatment of RAML, especially the central RAML. It can be a nephron-sparing alternative and recommended in well-selected patients that might prove to be safer, with equal efficacy, and should be further explored.

 

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[216]

TÍTULO / TITLE:  - Primary histiocytic sarcoma of the stomach: a case report with imaging findings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastroenterol. 2013 Jan 21;19(3):422-5. doi: 10.3748/wjg.v19.i3.422.

            ●● Enlace al texto completo (gratuito o de pago) 3748/wjg.v19.i3.422

AUTORES / AUTHORS:  - Shen XZ; Liu F; Ni RJ; Wang BY

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 332100, Zhejiang Province, China.

RESUMEN / SUMMARY:  - Histiocytic sarcoma (HS) is a rare malignant neoplasm that originates from a histiocytic hematopoietic lineage characterized by histiocytic differentiation and its corresponding immunophenotypic features. We herein reported a case of primary HS of the stomach which was confirmed through histopathologic examination and immunohistochemical staining. A 52-year-old woman presented with progressive  difficulty in feeding and dull pain in the epigastric region. Gastroscopy, endoscopic ultrasonography, double contrast examination, and computed tomography  revealed a mass located on the posterior wall of fundus and lesser curvature of the stomach. Microscopically, the cytoplasm of the tumor cells was abundant and eosinophilic. Immunohistochemical staining revealed that the tumor cells were positive for CD45RO and CD68. It is difficult to differentiate HS of stomach from other gastric malignancies by radiological evaluation alone. However, HS may be considered when a protruding and ulcerated mass in stomach shows heterogeneous hypervascular features. To the best of our knowledge, this is the first report in English language literature that emphasizes the imaging findings of human gastric HS.

 

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[217]

TÍTULO / TITLE:  - Kaposiform Hemangioendothelioma Infiltrates the Gut Wall: A Rare Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Hematol Oncol. 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MPH.0b013e31827e7fa5

AUTORES / AUTHORS:  - Kajiwara R; Yokosuka T; Sasaki K; Takeuchi M; Kikuchi M; Kato H; Yokota S

INSTITUCIÓN / INSTITUTION:  - Department of Pediatrics, Yokohama City University Hospital, Yokohama Kanagawa, Japan.

 

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[218]

TÍTULO / TITLE:  - Validation of a new multiple osteochondromas classification through Switching Neural Networks.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Med Genet A. 2013 Mar;161(3):556-60. doi: 10.1002/ajmg.a.35819. Epub 2013 Feb 8.

            ●● Enlace al texto completo (gratuito o de pago) 1002/ajmg.a.35819

AUTORES / AUTHORS:  - Mordenti M; Ferrari E; Pedrini E; Fabbri N; Campanacci L; Muselli M; Sangiorgi L

INSTITUCIÓN / INSTITUTION:  - Medical Genetic Department, Rizzoli Orthopaedic Institute (IOR), Bologna, Italy.

RESUMEN / SUMMARY:  - Multiple osteochondromas (MO), previously known as hereditary multiple exostoses  (HME), is an autosomal dominant disease characterized by the formation of several benign cartilage-capped bone growth defined osteochondromas or exostoses. Various clinical classifications have been proposed but a consensus has not been reached. The aim of this study was to validate (using a machine learning approach) an “easy to use” tool to characterize MO patients in three classes according to the  number of bone segments affected, the presence of skeletal deformities and/or functional limitations. The proposed classification has been validated (with a highly satisfactory mean accuracy) by analyzing 150 different variables on 289 MO patients through a Switching Neural Network approach (a novel classification technique capable of deriving models described by intelligible rules in if-then form). This approach allowed us to identify ankle valgism, Madelung deformity and limitation of the hip extra-rotation as “tags” of the three clinical classes. In  conclusion, the proposed classification provides an efficient system to characterize this rare disease and is able to define homogeneous cohorts of patients to investigate MO pathogenesis.

 

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[219]

TÍTULO / TITLE:  - Lipomatous lesions of the parotid gland: analysis of 70 cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Laryngoscope. 2013 Mar;123(3):651-6. doi: 10.1002/lary.23723. Epub 2013 Feb 9.

            ●● Enlace al texto completo (gratuito o de pago) 1002/lary.23723

AUTORES / AUTHORS:  - Starkman SJ; Olsen SM; Lewis JE; Olsen KD; Sabri A

INSTITUCIÓN / INSTITUTION:  - Mayo Medical School, College of Medicine, American University of Beirut, Beirut,  Lebanon.

RESUMEN / SUMMARY:  - OBJECTIVES/HYPOTHESIS: To investigate presenting signs and symptoms, preoperative workup, operative therapy, and morbidity of benign and malignant lipomatous lesions of the parotid gland. STUDY DESIGN: Medical literature review and retrospective chart review for all patients who underwent surgery for lipomatous  lesions of the parotid gland at our institution from 1959 to 2009. METHODS: Seventy patients underwent surgery for such lesions. Histologic sections were stained with hematoxylin-eosin and reviewed, and clinical information was obtained from hospital medical records for each case. RESULTS: Forty-nine patients (70.0%) were male and 21 (30.0%) female (mean age, 49.9 years). Of the lesions, 43 (63.2%) were intraparotid, 25 (36.8%) periparotid, 69 (98.6%) unilateral, and 1 (1.4%) bilateral (average size, 3.7 cm). Fifty-nine patients were treated with superficial or partial superficial parotidectomy, 10 were treated with total parotidectomy, and one was treated with parapharyngeal space dissection. Complications included six cases (8.6%) of facial paresis or paralysis and two cases of hematoma. No lesions recurred. CONCLUSIONS: We present the largest series, to our knowledge, of lipomatous lesions of the parotid gland. These masses, although rare, should be considered in the evaluation of a parotid  mass. This series provides insight into the clinical presentation, diagnostic evaluation, and surgical treatment of parotid lipomatous lesions. Surgical extent depends on lesion location in the gland. Lipomatous masses can be effectively treated surgically with low morbidity and high cure rates.

 

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[220]

TÍTULO / TITLE:  - Angiosarcoma of the parotid gland with a t(12;22) translocation creating a EWSR1-ATF1 fusion: a diagnostic dilemma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Pathol. 2013 Feb 20.

            ●● Enlace al texto completo (gratuito o de pago) 1136/jclinpath-2012-201433

AUTORES / AUTHORS:  - Gru AA; Becker N; Pfeifer JD

INSTITUCIÓN / INSTITUTION:  - Department of Pathology & Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.

 

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[221]

TÍTULO / TITLE:  - Endoscopic Findings with GI Angiosarcoma Correspond with the Propensity of These  Vascular Tumors to Cause GI Bleeding: Two Case Reports and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dig Dis Sci. 2013 Feb 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10620-013-2582-4

AUTORES / AUTHORS:  - Saad A; Cappell MS; Amin M

INSTITUCIÓN / INSTITUTION:  - Internal Medicine, William Beaumont Hospital, Royal Oak, MI, USA.

 

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[222]

TÍTULO / TITLE:  - The utility of balloon enteroscopy in the diagnosis of histiocytic sarcoma of the small intestine: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Int. 2013 Feb;63(2):120-4. doi: 10.1111/pin.12032. Epub 2013 Feb 21.

            ●● Enlace al texto completo (gratuito o de pago) 1111/pin.12032

AUTORES / AUTHORS:  - Miyazaki T; Arihiro S; Mitobe J; Aoki Y; Takikawa S; Saruta M; Matsuoka M; Koike K; Kato T; Kashiwagi H; Ikegami M; Tajiri H

INSTITUCIÓN / INSTITUTION:  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

RESUMEN / SUMMARY:  - The diagnosis of the rare neoplasm histiocytic sarcoma (HS) relies on morphology  and the presence of immunophenotypic features of histiocytic lineage. More than 57 cases, including 16 cases involving the gastrointestinal (GI) tract, have been described since the World Health Organization issued its classification system for tumors of hematopoietic and lymphoid tissue in 2001. HS is often diagnosed in its late stages, at which point the prognosis is poor. Only a small proportion of these patients can undergo surgical resection with curative intent. The present report describes how HS can be diagnosed at a stage of favorable prognosis using  balloon enteroscopy (BE), thereby enabling surgical resection before the development of metastases. This strategy is reviewed in the setting of a patient  with jejunal HS, followed by a discussion of data from 16 other reported cases of GI HS.

 

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[223]

TÍTULO / TITLE:  - Dedifferentiated liposarcoma with homologous lipoblastic differentiation: expanding the spectrum to include low-grade tumours.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Histopathology. 2013 Apr;62(5):702-10. doi: 10.1111/his.12068. Epub 2013 Feb 21.

            ●● Enlace al texto completo (gratuito o de pago) 1111/his.12068

AUTORES / AUTHORS:  - Liau JY; Lee JC; Wu CT; Kuo KT; Huang HY; Liang CW

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.

RESUMEN / SUMMARY:  - AIMS: Dedifferentiated liposarcoma (DDLPS) is traditionally defined as a non-lipogenic high-grade sarcoma arising from a well-differentiated liposarcoma that confers metastatic potential. Recently, DDLPSs with lipoblastic differentiation, i.e. morphologically lipogenic DDLPSs, were reported. Because of the lipoblastic differentiation, these tumours caused confusion, and were reported under different names. However, cytogenetic and molecular studies have revealed their DDLPS nature. So far, the cases reported have been high-grade pleomorphic liposarcoma-like tumours. In this study we have collected another series that contains low-grade tumours, and expand the histological spectrum. METHODS AND RESULTS: Eighteen cases of DDLPS with lipoblastic differentiation from various anatomical locations were analysed by routine histology, immunohistochemistry, and MDM2 fluorescence in-situ hybridization. Two main histological patterns were seen: one featured a spindle cell sarcoma containing lipoblasts with variable nuclear pleomorphism, and the other a pleomorphic liposarcoma-like tumour including the epithelioid variant. Two cases showed low nuclear grade and lipogenic activity in the metastatic foci. CDK4, MDM2 and p16(INK) (4a) overexpression was seen in all except one case. MDM2 amplification  was found in all 16 cases tested. CONCLUSIONS: We have expanded the spectrum of this variant of DDLPS to include low-grade tumours, in which a careful search for increased mitotic activity is essential. Like conventional DDLPS, these tumours are capable of metastasis.

 

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[224]

TÍTULO / TITLE:  - Successful surgical removal of a giant interventricular fibroma: surgical approach without ventriculotomy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Surg. 2013 Mar;95(3):1072-4. doi: 10.1016/j.athoracsur.2012.08.028.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.athoracsur.2012.08.028

AUTORES / AUTHORS:  - Kimura N; Matsubara M; Atsumi N; Terada M

INSTITUCIÓN / INSTITUTION:  - Department of Cardiovascular Surgery, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan. naritaku@mvf.biglobe.ne.jp

RESUMEN / SUMMARY:  - A 14-month-old boy was transported to our hospital by ambulance because of cardiopulmonary arrest after the sudden onset of convulsions. He was resuscitated and transthoracic echocardiography showed a giant interventricular tumor. The cause of this episode was thought to be ventricular arrhythmias induced by the tumor. At operation, an incision line was confirmed by direct ultrasonography. The heart was incised directly on the interventricular septum. The tumor was carefully dissected and completely removed without entering the ventricular cavity. Histologic analysis revealed a fibroma. The patient’s postoperative course was uneventful, and he remains well without episodes of heart failure or ventricular arrhythmia.

 

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[225]

TÍTULO / TITLE:  - Giant cell tumor of bone in a child with Goltz syndrome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Dev Pathol. 2013 Mar 26.

            ●● Enlace al texto completo (gratuito o de pago) 2350/13-01-1295-CR.1

AUTORES / AUTHORS:  - Shao L; Mardis N; Nopper A; Jarka D; Singh V

INSTITUCIÓN / INSTITUTION:  - a Children’s Mercy Hospital, Pathology.

RESUMEN / SUMMARY:  - Abstract Giant cell tumor of bone is a neoplasm rarely seen in children. Goltz syndrome is a disorder that affects multiple ectodermal and mesodermal tissues and has occasionally been associated with giant cell tumors of bone. Our case of  giant cell tumor in a five-year-old girl with Goltz syndrome suggests that this syndrome provides a unique situation, wherein the practitioner should consider giant cell tumor of bone even in a pediatric setting.

 

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[226]

TÍTULO / TITLE:  - Congenital leiomyoma of the distal ileum associated with ileal atresia: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Surg. 2013 Mar;48(3):e33-5. doi: 10.1016/j.jpedsurg.2012.12.052.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpedsurg.2012.12.052

AUTORES / AUTHORS:  - Ince E; Oguzkurt P; Canpolat ET; Temiz A; Hicsonmez A

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Surgery, Baskent University Faculty of Medicine, Ankara,  Turkey. Electronic address: inceemine@yahoo.com.

RESUMEN / SUMMARY:  - Association of distal ileal atresia with leiomyoma is a quite rare condition. Herein, we describe a newborn who underwent surgery for ileal atresia and was found to have leiomyoma on pathological examination in the atretic segment. The presence of leiomyoma may indicate a malformation during recanalization and could play a role in the etiology of intestinal atresia. Thus, some cases of atresia may be due to tumor (leiomyoma) in the bowel wall.

 

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[227]

TÍTULO / TITLE:  - MRI “row of dots sign” in gossypiboma: an enlarging mass 8 months after sarcoma resection.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Skeletal Radiol. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00256-013-1596-5

AUTORES / AUTHORS:  - Shiraev T; Bonar SF; Stalley P; Anderson SE

INSTITUCIÓN / INSTITUTION:  - University of Notre Dame, Sydney, 160 Oxford St, Darlinghurst, 2010, Australia, timothy.shiraev1@my.nd.edu.au.

RESUMEN / SUMMARY:  - The retention of foreign bodies after surgery is rare, but carries significant morbidity and mortality as well as financial and legal implications. Such retained items cause a foreign-body reaction, which in the case of cotton-based materials are called gossypibomas. We present the case of an 84-year-old woman with a pseudotumor secondary to a retained dressing gauze roll, presenting 5 months after resection of a gluteal sarcoma, which had raised concerns of local recurrence. We also outline the imaging modalities that may assist in diagnosis of a retained foreign body, and suggest the MRI “row of dots” sign as a useful radiological feature associated with gossypiboma. Awareness of the imaging appearances of retained foreign bodies allows the inclusion of this possibility in differential diagnosis of a mass in patients with a surgical history.

 

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[228]

TÍTULO / TITLE:  - Calcifying fibrous tumour originating from the right cardiac ventricle in a child.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cardiol Young. 2013 Feb 7:1-3.

            ●● Enlace al texto completo (gratuito o de pago) 1017/S1047951113000073

AUTORES / AUTHORS:  - Zhang B; Zhang W; Wang X

INSTITUCIÓN / INSTITUTION:  - 1 Centre of Cardiovascular Surgery of Liuhuaqiao Hospital, Guangzhou, Guangdong,  People’s Republic of China.

RESUMEN / SUMMARY:  - Calcifying fibrous tumour is a rare benign fibrous lesion. It is paucicellular, with fibroblasts, dense collagenisation, psammomatous and dystrophic calcification, and patchy lymphoplasmacytic infiltrates. Calcifying fibrous tumour was first described in subcutaneous and deep soft tissues, and has been reported all over the body. However, calcifying fibrous tumour originating from the heart is extremely rare. This article describes the case of a giant calcifying fibrous tumour arising from the right ventricle in a child, where the  tumour was totally resected and no recurrence was observed during a 4-year follow-up period.

 

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[229]

TÍTULO / TITLE:  - An uncommon case of a lipoma located in the right atrium.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cardiothorac Surg. 2013 Mar 21.

            ●● Enlace al texto completo (gratuito o de pago) 1093/ejcts/ezt167

AUTORES / AUTHORS:  - De Cicco G; Di Matteo G; D’Aloia A; Coletti G

INSTITUCIÓN / INSTITUTION:  - Cardiac Surgery Unit, Spedali Civili Hospital, Brescia, Italy.

 

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[230]

TÍTULO / TITLE:  - Tuberous sclerosis complex-associated kidney angiomyolipoma: from contemplation to action.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nephrol Dial Transplant. 2013 Feb 14.

            ●● Enlace al texto completo (gratuito o de pago) 1093/ndt/gft009

AUTORES / AUTHORS:  - Pirson Y

INSTITUCIÓN / INSTITUTION:  - Nephrology, Universite Catholique de Louvain, Bruxelles, Belgium.

 

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[231]

TÍTULO / TITLE:  - A prospective study of brachytelephalangic chondrodysplasia punctata: identification of arylsulfatase E mutations, functional analysis of novel missense alleles, and determination of potential phenocopies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genet Med. 2013 Mar 7. doi: 10.1038/gim.2013.13.

            ●● Enlace al texto completo (gratuito o de pago) 1038/gim.2013.13

AUTORES / AUTHORS:  - Matos-Miranda C; Nimmo G; Williams B; Tysoe C; Owens M; Bale S; Braverman N

INSTITUCIÓN / INSTITUTION:  - Department of Human Genetics, Montreal Children’s Hospital Research Institute, McGill University, Montreal, Quebec, Canada.

RESUMEN / SUMMARY:  - Purpose:The only known genetic cause of brachytelephalangic chondrodysplasia punctata is X-linked chondrodysplasia punctata 1 (CDPX1), which results from a deficiency of arylsulfatase E (ARSE). Historically, ARSE mutations have been identified in only 50% of male patients, and it was proposed that the remainder might represent phenocopies due to maternal-fetal vitamin K deficiency and maternal autoimmune diseases.Methods:To further evaluate causes of brachytelephalangic chondrodysplasia punctata, we established a Collaboration Education and Test Translation program for CDPX1 from 2008 to 2010. Of the 29 male probands identified, 17 had ARSE mutations that included 10 novel missense alleles and one single-codon deletion. To determine pathogenicity of these and additional missense alleles, we transiently expressed them in COS cells and measured arylsulfatase E activity using the artificial substrate, 4-methylumbelliferyl sulfate. In addition, clinical data were collected to investigate maternal effects and genotype-phenotype correlations.Results:In this  study, 58% of males had ARSE mutations. All mutant alleles had negligible arylsulfatase E activity. There were no obvious genotype-phenotype correlations.  Maternal etiologies were not reported in most patients.Conclusion:CDPX1 is caused by loss of arylsulfatase E activity. Around 40% of male patients with brachytelephalangic chondrodysplasia punctata do not have detectable ARSE mutations or known maternal etiological factors. Improved understanding of arylsulfatase E function is predicted to illuminate other etiologies for brachytelephalangic chondrodysplasia punctata.Genet Med advance online publication 7 March 2013Genetics in Medicine (2013); doi:10.1038/gim.2013.13.

 

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[232]

TÍTULO / TITLE:  - Patterns of renal angiomyolipoma regression post embolisation on medium- to long-term follow-up.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Radiol. 2013 Apr;86(1024):20120633. doi: 10.1259/bjr.20120633. Epub 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1259/bjr.20120633

AUTORES / AUTHORS:  - Patatas K; Robinson GJ; Ettles DF; Lakshminarayan R

INSTITUCIÓN / INSTITUTION:  - Vascular Radiology Department, Hull Royal Infirmary, Hull, UK. kpatatas@hotmail.com

RESUMEN / SUMMARY:  - OBJECTIVE: To assess the patterns of regression of renal angiomyolipoma (AML) post embolisation and report the outcomes related to the use of different embolic materials. METHODS: A retrospective review of all patients who underwent embolisation for renal AML at our institution between January 2004 and April 2012. RESULTS: 13 patients underwent 16 episodes of embolisation. Coils were used as the primary embolisation material in 10 episodes and microspheres in 6 episodes. The size reduction rate highly correlated on CT follow-up between the two groups, with 25.6% vs 22.7% reduction at 12 months, 27.5% vs 25.1% at 24 months, 35.0% vs 33.0% at 36 months and 35.0% vs 36.8% at 48 months. During follow-up, all tumours reduced in size with one patient requiring subsequent embolisation whose tumour reduced by only 6.5% after 1 year and subsequently exhibited regrowth after 4 years. Two patients presented with rebleeding and underwent repeat embolisation. Our overall retreatment rate (23%) is well within  the literature range (up to 37%). None of the patients underwent surgery. CONCLUSION: The majority of AML shrinkage occurs within the first year following  embolisation and appears to plateau after 3 years, which could have an impact on  follow-up strategy. The percentage reduction at 1 year may reflect the long-term  effect of embolisation with tumours demonstrating minor size reduction more likely to relapse at long-term follow-up. Embolisation of renal AML produces durable long-term results regardless of the choice of embolic agent. ADVANCES IN  KNOWLEDGE: These findings provide information to guide CT follow-up of renal AML  post embolisation.

 

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[233]

TÍTULO / TITLE:  - The CD133+ subpopulation of the SW982 human synovial sarcoma cell line exhibits cancer stem-like characteristics.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Oncol. 2013 Apr;42(4):1399-407. doi: 10.3892/ijo.2013.1826. Epub 2013 Feb 15.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ijo.2013.1826

AUTORES / AUTHORS:  - Liu A; Feng B; Gu W; Cheng X; Tong T; Zhang H; Hu Y

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, First Affiliated Hospital, Harbin Medical University, Harbin 150001, P.R. China.

RESUMEN / SUMMARY:  - Several soft tissues sarcomas have been reported to contain cancer stem-like cells (CSCs) or tumor-initiating cells, based on their ability to initiate and sustain tumor growth. However, these cells have not yet been identified in the human synovial sarcoma cell line SW982. CD133, a surface glycoprotein specific to stem and progenitor cells, has been described as a CSC marker in different tumor  types. In the present study, we identified a CSC subpopulation in SW982 cells using the CD133 cell surface marker. CD133-positive (CD133+) cells were identified in SW982 cells (8.59%); these cells showed an increased ability to form spherical colonies and could self-renew in serum-starved culture conditions, compared to CD133-negative (CD133-) cells. Real-time PCR analysis of stemness genes revealed that the CD133+ subpopulation expresses higher levels of Bmi1, c-Myc, Nanog, Oct3/4 and Sox2. CD133+ cells showed increased resistance to cisplatin (CDDP) and doxorubicin (DXR), possibly due to upregulation of the ABCG2 drug transporter gene. In vivo studies revealed that the CD133+ subpopulation is  highly tumorigenic. These findings indicate that CD133+ SW982 cells have characteristics similar to CSCs. This discovery may lead to the development of novel therapies that specifically target CD133+ synovial sarcoma CSCs.

 

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[234]

TÍTULO / TITLE:  - T-cadherin expression in uterine leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Gynecol Obstet. 2013 Mar 6.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00404-013-2732-0

AUTORES / AUTHORS:  - Wang L; Mou X; Xiao L; Tang L

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Room 1, Youyi Road, Yuanjiagang, Chongqing, 400016, China, w.l.fang.99@gmail.com.

RESUMEN / SUMMARY:  - OBJECTIVE: T-cadherin is a tumor-suppressor with low expression in many malignant tumors, but with high expression in endothelial cells and so on. In this study we investigated whether T-cadherin was expressed and if together with bFGF play a role in the occurrence and development of uterine leiomyoma. METHOD: Uterine leiomyoma, the adjacent normal myometrium, control normal myometrium without uterine leiomyoma and vascular features of myoma were collected. Immunohistochemistry, western blot and relative quantitative real time PCR were used to evaluate bFGF and T-cadherin on the three specimens. Data were statistically analysed. RESULTS: T-cadherin was observed on the leiomyoma cellular layers but not in the endochylema, extracellular matrix and leiomyoma vascular endothelial cell, bFGF in the leiomyoma endochylema but not observed in  the extracellular matrix and leiomyoma vascular endothelial cell. The protein and mRNA expression of bFGF and T-cadherin in uterine leiomyoma were significantly with higher expression than that in adjacent normal myometrium and control normal myometrium. In addition, T-cadherin correlated well with bFGF. There was relationship between T-cadherin and color Doppler flow imaging (CDFI). CONCLUSION: bFGF and T-cadherin have high expressions in uterine leiomyoma, and T-cadherin is associated with CDFI, indicating that a cross talk between bFGF and T-cadherin plays an important role in the occurrence and development of uterine leiomyoma or even malignant tumors.

 

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[235]

TÍTULO / TITLE:  - A Case of Pleomorphic Fibroma of the Skin Presenting as Intradermal Nodule.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Dermatopathol. 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1097/DAD.0b013e318288cd71

AUTORES / AUTHORS:  - Nakamura Y; Nakamura A; Muto M

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.

 

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[236]

TÍTULO / TITLE:  - Angiosarcoma of the hypopharynx: case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Coll Antropol. 2012 Nov;36 Suppl 2:185-7.

AUTORES / AUTHORS:  - Kotromanovic Z; Mihalj H; Zubcic Z; Vceva A; Birtic D; Kotromanovic Z; Rajc J

INSTITUCIÓN / INSTITUTION:  - J. J. Strossmayer, University, Osijek University Hospital Centre, Department of Otorhinolaryngology and Head and Neck Surgery, Osijek, Croatia.

RESUMEN / SUMMARY:  - Angiosarcomas are malignant neoplasias of rapid growth that emerge from endothelial cells. They are rarely found in the area of the head and neck and account less than 0.1% of all head and neck malignancies. In some cases it has been linked to trauma, radiation and angiectasia but the etiology mainly remains  unknown. Here we report a case of angiosarcoma of pyriform sinus manifested by dysphagia and dysphonia. The patient underwent endoscopic hypopharyngeal excision followed by radiation therapy with a good result. Our patient remains tumor free  after two years. The purpose of this article is to add another case of primary angiosarcoma of a rare site, the hypopharynx.

 

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[237]

TÍTULO / TITLE:  - Real-time elastography for distinguishing angiomyolipoma from renal cell carcinoma: preliminary observations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - AJR Am J Roentgenol. 2013 Apr;200(4):W369-75. doi: 10.2214/AJR.12.9139.

            ●● Enlace al texto completo (gratuito o de pago) 2214/AJR.12.9139

AUTORES / AUTHORS:  - Tan S; Ozcan MF; Tezcan F; Balci S; Karaoglanoglu M; Huddam B; Arslan H

INSTITUCIÓN / INSTITUTION:  - 1 Department of Radiology, Ankara Ataturk Education and Research Hospital, 06800  Eskisehir Yolu 8.km No: 3 Bilkent, Ankara, Turkey.

RESUMEN / SUMMARY:  - OBJECTIVE. The objective of this study was to determine the diagnostic performance of sonoelastography for differentiating angiomyolipomas from renal cell carcinomas. SUBJECTS AND METHODS. Twenty-eight angiomyolipomas and 19 renal  cell carcinomas were prospectively examined with real-time elastography. Lesions  were classified according to four elastographic patterns on the basis of the distribution of the blue area (representing no strain and hardest tissue component). The elasticity patterns and the strain ratios of the angiomyolipomas  and renal cell carcinomas were evaluated independently by two observers. Diagnostic performance and interobserver agreement were analyzed. RESULTS. All angiomyolipomas were classified as having a high-strain elastographic pattern (blue areas in < 50% of lesion, considered type 1 or type 2) by both radiologists, whereas 18 of 19 renal cell carcinomas were classified as having a  low-strain elastographic pattern (blue areas in >/= 50% of lesion, considered type 3 or 4) by both radiologists. The respective mean strain ratios measured by  two radiologists were 0.15 +/- 0.06 and 0.18 +/- 0.09 for the angiomyolipomas and 0.64 +/- 0.15 and 0.63 +/- 0.19 for the renal cell carcinomas. There were significant differences between the elasticity patterns and strain ratios for angiomyolipomas and renal cell carcinomas (p < 0.001). Interobserver agreement was excellent for elasticity patterns and strain ratios, with a weighted kappa coefficient of 0.96 and an intraclass correlation coefficient score of 0.95. CONCLUSION. Our results show that real-time elastography may be useful in differentiating angiomyolipomas from renal cell carcinomas, by use of both elasticity patterns and strain ratios.

 

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[238]

TÍTULO / TITLE:  - Prognostic factors of metastatic renal cell carcinoma with extensive sarcomatoid  component.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cancer Res Clin Oncol. 2013 Feb 9.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00432-013-1386-4

AUTORES / AUTHORS:  - Park I; Cho YM; Lee JL; Ahn JH; Lee DH; Song C; Hong JH; Kim CS; Ahn H

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, Korea, ingni79@hanmail.net.

RESUMEN / SUMMARY:  - PURPOSE: To evaluate clinical characteristics including the response to targeted  therapy, the benefits of cytoreductive nephrectomy, or the prognostic factors in  advanced renal cell carcinoma (RCC) with extensive sarcomatoid component (ESC), a rare but fatal disease. METHODS: Data from 37 consecutive patients with metastatic or recurrent RCC with ESC (>/=25 % on resected kidney or exclusive sarcomatoid histology on needle biopsy) were analyzed. RESULTS: Of the 37 patients, 27 patients (73 %) had synchronous metastatic disease. The median percentage of sarcomatoid component (PSC) was 50 % (range 25-93 %). Twenty (74 %) of the 27 synchronous metastatic patients underwent cytoreductive nephrectomy. Of the nine patients undergoing cytokine therapy, none showed objective responses. Two (15 %) of the 13 patients undergoing targeted agent therapy had partial responses, and five patients (38 %) achieved stable disease. The median overall survival for all patients was 5.9 months [95 % confidence interval (CI) 1.0-10.9]. In multivariate analysis, age (>58 years), ECOG performance status (>1), PSC (>50 %), and time from first diagnosis to advanced disease (<6 months)  remained independent prognostic factors. Neither the type of systemic therapy nor cytoreductive nephrectomy had an effect on survival. CONCLUSIONS: Patients with RCC with ESC have a dismal clinical course, and the majority of patients have rapid disease progression, especially in response to immunotherapy. Four clinical factors can be used to model survival outcomes for advanced RCC with ESC and may  be helpful in selecting patients for aggressive treatment.

 

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[239]

TÍTULO / TITLE:  - Inferior turbinate osteoma as a cause of unilateral nose obstruction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Coll Antropol. 2012 Nov;36 Suppl 2:189-91.

AUTORES / AUTHORS:  - Grabovac S; Hadzibegovic AD; Markesic J

INSTITUCIÓN / INSTITUTION:  - Bjelovar General Hospital, Department of Otorhinolaryngology, Bjelovar, Croatia.

RESUMEN / SUMMARY:  - Osteomas are benign, slow growing bone tumors often seen in paranasal sinuses, mostly in the frontal sinus, whereas they are rare in the nasal cavity. Inferior  turbinate osteoma is extremely rare and our case is the third reported in the literature to date. Symptoms vary depending on the location, size and spreading and nasal obstruction is the most common symptom. Treatment of osteomas is surgical and is reserved only for rapidly growing osteomas with symptoms of infection or compression. Although endoscopic surgery is preferred modality, external approach with lateral rhinotomy should be considered with larger osteomas especially those that involve the ethmoid labyrinth. In cases like ours, when large osteoma is localized on the inferior nasal turbinate, sublabial incision through the vestibulum is very suitable approach because it provides wide access and good visibility and leaves no visible scar.

 

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[240]

TÍTULO / TITLE:  - Valve replacement for papillary fibroelastoma involving the mitral valve chordae.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Surg. 2013 Apr;95(4):1458. doi: 10.1016/j.athoracsur.2012.09.014.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.athoracsur.2012.09.014

AUTORES / AUTHORS:  - Murakami M; Kurazumi H; Suzuki R; Takahashi M; Mikamo A; Hamano K

INSTITUCIÓN / INSTITUTION:  - Division of Cardiac Surgery, Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan. Electronic address: muraka3@yamaguchi-u.ac.jp.

 

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[241]

TÍTULO / TITLE:  - Malignant solitary fibrous tumor of the left ventricular epicardium.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Surg. 2013 Apr;95(4):1447-50. doi: 10.1016/j.athoracsur.2012.08.033.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.athoracsur.2012.08.033

AUTORES / AUTHORS:  - Taguchi S; Mori A; Yamabe K; Suzuki R; Nishizawa K; Hasegawa I; Irie R

INSTITUCIÓN / INSTITUTION:  - Departments of Cardiovascular Surgery, Cardiology, Radiology, and Pathology, Kawasaki Municipal Hospital, Kanagawa, Japan. Electronic address: staguchi@kmh.gr.jp.

RESUMEN / SUMMARY:  - Reports describing solitary fibrous tumors of the pericardium are rare. Surgical  treatment was performed on a 49-year-old woman with a large pericardial mass. The mass was attached to the left ventricular wall with a broad stalk and was free of the parietal pericardium. It was apparent macroscopically that the tumor had invaded the left ventricular muscle. On histopathology, the tumor was diagnosed as a solitary fibrous tumor with low-grade malignancy.

 

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[242]

TÍTULO / TITLE:  - Anterior mediastinal angiomyolipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Surg. 2013 Apr;95(4):1431-2. doi: 10.1016/j.athoracsur.2012.07.066.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.athoracsur.2012.07.066

AUTORES / AUTHORS:  - Candas F; Berber U; Yildizhan A; Yiyit N; Gorur R; Isitmangil T

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. Electronic address: fhcandas@yahoo.com.

RESUMEN / SUMMARY:  - Angiomyolipomas are benign, solitary, noninvasive mesenchymal tumors. They most often arise in the kidney. Extrarenal presentations of these tumors are in skin,  orophaynx, abdominal wall, gastrointestinal tract, heart, lung, liver, uterus, penis, and spinal cord. Angiomyolipoma of the mediastinum is extremely rare and is composed of an admixture of fat, smooth muscle cells, and tortuous, thick-walled, small to medium sized blood vessels. We present a surgically confirmed case of anterior mediastinal angiomyolipoma incidentally diagnosed in an asymptomatic patient.

 

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[243]

TÍTULO / TITLE:  - Osteoblastic cell response on biphasic fluor-hydroxyapatite/strontium-substituted hydroxyapatite (FHA/SrHA) coatings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Biomed Mater Res A. 2013 Mar 27. doi: 10.1002/jbm.a.34723.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jbm.a.34723

AUTORES / AUTHORS:  - Yin P; Feng F; Lei T; Zhong X; Jian X

INSTITUCIÓN / INSTITUTION:  - Xiangya Hospital, Central South University, Changsha 410008, China.

RESUMEN / SUMMARY:  - Fluor-hydroxyapatite/strontium-substituted hydroxyapatite (FHA/SrHA) biphasic coatings with F and Sr elements incorporated simultaneously into one coating layer were prepared on titanium substrate via colloidal-sol gel method. The bioactivity of the as-prepared FHA/SrHA biphasic coatings was evaluated in vitro  by immersion in simulated body fluid (SBF). All the biphasic coatings exhibited great ability to induce apatite precipitation on their surfaces. In vitro cell responses were evaluated using osteoblast-like MG63 cells in terms of cell proliferation and differentiation (alkaline phosphatase activity and osteocalcin  level). The biphasic coatings show significantly positive effects on the viability and functional activity of osteoblastic cells with clear evidence that  an optimum SrHA amount dose exists, indicating that the coexistence of FHA and SrHA had a synergistic stimulatory effect. This finding suggests the potential use of this colloidal-sol gel derived FHA/SrHA biphasic coatings for hard tissue  applications.

 

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[244]

TÍTULO / TITLE:  - Pleomorphic malignant histiocytoma of pulmonary arteries presenting as pulmonary  aneurysms.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Surg. 2013 Mar;95(3):1091-3. doi: 10.1016/j.athoracsur.2012.08.018.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.athoracsur.2012.08.018

AUTORES / AUTHORS:  - De La Cerda Belmont GA; Lezama Urtecho CA

INSTITUCIÓN / INSTITUTION:  - Department of Cardiothoracic Surgery and Circulatory Assistance, General Hospital Gaudencio Gonzalez Garza, La Raza Medical National Center, Social Security Services of Mexico, Azcapotzalco, Mexico. guar20382@hotmail.com

RESUMEN / SUMMARY:  - Pulmonary aneurysms and primary neoplasms of the great vessels are very rare entities; pulmonary aneurysms are commonly associated with congenital heart diseases, and less frequently in atherosclerosis, medial cystic necrosis, trauma, infection, and inflammatory processes. Many patients have pulmonary hypertension, most frequently resulting from pulmonary artery sarcomas mimicking pulmonary thromboembolism. Symptoms are vague. In 30% of cases, rupture and death occur, related to pulmonary aneurysms. We present the case of a patient with a diagnosis of pulmonary artery pleomorphic malignant histiocytoma that presented as a right  pulmonary aneurysm thrombosis and a contained rupture of a left pulmonary aneurysm.

 

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[245]

TÍTULO / TITLE:  - High expression of cyclooxygenase-2 in uterine fibroids and its correlation with  cell proliferation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Obstet Gynecol Reprod Biol. 2013 Feb 8. pii: S0301-2115(13)00046-8. doi: 10.1016/j.ejogrb.2013.01.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejogrb.2013.01.006

AUTORES / AUTHORS:  - Ke X; Dou F; Cheng Z; Dai H; Zhang W; Qu X; Ding P; Zuo X

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Yangpu District Central Hospital, Shanghai 200090, China.

RESUMEN / SUMMARY:  - OBJECTIVE: To investigate the expression of cyclooxygenase-2 (COX-2) in uterine fibroids and healthy uterine smooth muscle as well as its role in the pathogenesis of uterine fibroids. METHODS: We collected uterine fibroid tissues and their paired adjacent healthy uterine smooth muscle tissues from 30 cases of  uterine fibroids. We used immunohistochemistry and quantitative real-time PCR, as well as western blot to detect COX-2 expression. Using the COX-2 inhibitors NS-398 and celecoxib, we observed the response to the inhibitors in the healthy and fibroid smooth muscle cell pairs. RESULTS: COX-2 was detected by immunohistochemistry in both uterine fibroids and uterine smooth muscle, with higher immunoreactivity in uterine fibroids; the positive index of the smooth muscle cells was 11.90 and the positive index of uterine fibroids cells was 46.50 (P<0.05). The expression of COX-2 mRNA in uterine fibroids was higher (0.122+/-0.062) than in normal smooth muscle tissue (0.025+/-0.009; P<0.05). Also, the western blot results showed that COX-2 expression was significantly higher in uterine fibroid cases, as compared to the expression in uterine smooth  muscle. Immunofluorescence showed that the occurrence of COX-2 was obviously higher in smooth muscle cells of uterine fibroids than in the healthy smooth muscle cells. NS-398 or celecoxib significantly inhibited the proliferation of smooth muscle cells of uterine fibroids, but did not inhibit the proliferation of healthy smooth muscle cells. Accordingly, NS-398 or celecoxib significantly reduced the expression of the downstream metabolite of COX-2, PGE2, in the smooth muscle cells of uterine fibroids, but not in healthy smooth muscle cells. CONCLUSION: COX-2 expression in uterine fibroids was significantly higher than in healthy uterine smooth muscles. The inhibition of COX-2 activity significantly reduced the proliferation of smooth muscle cells of the uterine fibroids, suggesting that COX-2 plays an important role in the pathogenesis of uterine fibroids.

 

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[246]

TÍTULO / TITLE:  - Mixed adenoneuroendocrine carcinoma of the gallbladder with squamous cell carcinomatous and osteosarcomatous differentiation: Report of a case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Int. 2013 Feb;63(2):113-9. doi: 10.1111/pin.12029. Epub 2013 Feb 22.

            ●● Enlace al texto completo (gratuito o de pago) 1111/pin.12029

AUTORES / AUTHORS:  - Shintaku M; Kataoka K; Kawabata K

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Osaka Red Cross Hospital, Osaka, Japan.

RESUMEN / SUMMARY:  - An extremely rare case of mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder is reported, in which the tumor showed diverse differentiation toward neuroendocrine tumor (grade 2), tubular adenocarcinoma, squamous cell carcinoma,  and, in addition, osteosarcoma. The patient was an 80-year-old man, who underwent cholecystectomy because of a large polypoid tumor filling the gallbladder lumen.  The tumor consisted of an intimate admixture of neuroendocrine tumor (grade 2) and tubular adenocarcinoma, and, in many areas, cell nests of neuroendocrine tumor appeared to bud off from tubular structures of the adenocarcinoma, in a manner resembling the ‘ductulo-insular complex’ seen in nesidioblastosis of the pancreas. Small areas of squamous cell carcinoma were also found. The stroma consisted of a dense proliferation of atypical spindle cells showing focal osteosarcomatous differentiation, and an apparent transition from an epithelial tissue component to atypical spindle cells was observed. Immunohistochemically, neuroendocrine cells were positive for synaptophysin, chromogranin A, and serotonin, and the sarcomatoid stroma was partly immunoreactive for cytokeratin.  The present case is the first example of MANEC of the gallbladder with simultaneous squamous cell carcinomatous and osteosarcomatous differentiation. ‘Neometaplasia’ of carcinoma cells in diverse directions was considered the most  plausible explanation for the formation of this multifaceted neoplasm.

 

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[247]

TÍTULO / TITLE:  - Metastatic epithelioid angiosarcoma to the mandible: report of a case and review  of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Oral Maxillofac Surg. 2013 Mar 14. pii: S0901-5027(13)00068-4. doi: 10.1016/j.ijom.2013.02.005.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijom.2013.02.005

AUTORES / AUTHORS:  - Peacock ZS; Lam DK; Cox DP; Schmidt BL

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA. Electronic address: zpeacock@partners.org.

RESUMEN / SUMMARY:  - Angiosarcoma and its epithelioid variant are vascular malignancies that rarely affect the facial skeleton. Epithelioid angiosarcoma resembles carcinoma and can  be difficult to diagnose. A case is presented of metastatic epithelioid angiosarcoma to the mandible from an angiosarcomatoid portion of renal carcinoma. The diagnostic challenge is outlined and the literature is reviewed.

 

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[248]

TÍTULO / TITLE:  - Epithelioid sarcoma presenting as radial mononeuropathy: anatomical, magnetic resonance neurography and diffusion tensor imaging appearances.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Skeletal Radiol. 2013 Mar 1.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00256-013-1591-x

AUTORES / AUTHORS:  - Wadhwa V; Salaria SN; Thakkar RS; Chhabra A

INSTITUCIÓN / INSTITUTION:  - The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601, N. Caroline Street, Baltimore, MD, 21287, USA.

RESUMEN / SUMMARY:  - The authors report an unusual case of radial mononeuropathy caused by epithelioid sarcoma and describe the anatomical 3-Tesla MR neurography and the functional diffusion tensor imaging findings of the case, which were subsequently confirmed  on surgical excision and histopathology.

 

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[249]

TÍTULO / TITLE:  - A retrospective study on craniofacial fibrous dysplasia: Preoperative serum alkaline phosphatase as a prognostic marker?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniomaxillofac Surg. 2013 Feb 4. pii: S1010-5182(12)00304-6. doi: 10.1016/j.jcms.2012.12.007.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcms.2012.12.007

AUTORES / AUTHORS:  - Ma J; Liang L; Gu B; Zhang H; Wen W; Liu H

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery (Head: Prof. Haizhong Zhang), The General Hospital of the People’s Liberation Army, Beijing, China; Department of Stomatology (Head: Prof. Hongchen Liu), The General Hospital of the People’s Liberation Army, Beijing, China.

RESUMEN / SUMMARY:  - BACKGROUND: Craniofacial fibrous dysplasia (CFD) often requires surgery to correct facial deformity and prevent functional impairment. However, recurrence is common, and there is no reliable prognostic biomarker. The aim of this paper is to evaluate the possibility of using preoperative alkaline phosphatase (ALP) as a prognostic marker for CFD. MATERIAL AND METHODS: Forty-nine patients with CFD who underwent surgery from 2000 to 2011 were selected. The relationship between preoperative ALP and age, gender, lesion type and prognosis was investigated. RESULTS: The recurrence rate was 31.8% in patients who received conservative bone contouring. Patients with recurrence did not show significantly higher levels and abnormal rates of ALP than patients without recurrence. Young patients and those with polyostotic CFD showed higher ALP levels than adults and  those with monostotic CPD (P < 0.05). Although CFD patients showed higher levels  and abnormal rates of ALP than the control group, significant levels were not reached (P > 0.05). No correlation between age, gender, type, ALP and recurrence  could be established using the logistic regression model. CONCLUSION: Preoperative ALP may not be a reliable prognostic marker of CFD based on the findings in this study. Close follow-up is recommended after conservative bone contouring.

 

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[250]

TÍTULO / TITLE:  - Metformin Synergistically Enhances Antitumor Activity of Histone Deacetylase Inhibitor Trichostatin A Against Osteosarcoma Cell Line.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - DNA Cell Biol. 2013 Mar 1.

            ●● Enlace al texto completo (gratuito o de pago) 1089/dna.2012.1926

AUTORES / AUTHORS:  - Duo J; Ma Y; Wang G; Han X; Zhang C

INSTITUCIÓN / INSTITUTION:  - Key Laboratory of Cancer Prevention and Therapy, Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital , Tianjin, China .

RESUMEN / SUMMARY:  - Oral hypoglycemic agent metformin is commonly used for treating type II diabetes; however, initial reports demonstrated that it could be used for suppressing tumor growth in vitro and in vivo. Moreover, novel potential anticancer drug histone deacetylase (HDAC) and inhibitor trichostatin A (TSA) have been extensively studied for inducing various malignancies growth inhibition, cell cycle arrest, and apoptosis. The object of the present study was to investigate the anti-proliferation and apoptosis induction effects of metformin and TSA in osteosarcoma cell line, and to explore the mechanism of metformin and TSA in combination to inhibit the proliferation of osteosarcoma cells. After treating with metformin and TSA, the viability of osteosarcoma cell lines (MG-63 and LM8)  was analyzed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) at various concentrations, cell cycle analysis of MG-63 and LM8 cell was performed by flow cytometry. Real-time polymerase chain reaction and Western Blotting were performed to determine the expression of apoptosis-related genes and proteins such as Caspase-3, Bcl-2/Bax, Cyclin D1, and p21. Protein expression of the molecules involved in 5’-adenosine monophosphate-activated protein kinase  (AMPK) signaling pathway after treatment with combination was determined by Western blotting. Moreover, orthotopic xenograft tumors were challenged in nude mice to establish the murine model; tumor weight and tumor volume were monitored  after drug administration separately or combined via the intraperitoneal (i.p.) route. MTT assays showed that the viability of osteosarcoma cell lines in the combination group (10 mM metformin, 0.3 muM TSA) decreased in a concentration- and time-dependent manner; moreover, the cell cycle of MG-63 and LM8 in the combination group could be arrested in G1/G2 phase higher number compared with drug use separately. Furthermore, a combination of these drugs does not act via the AMPK signaling pathway to induce MG-63 osteosarcoma cell line growth inhibition and apoptosis. As data have showed here, metformin cotreatment increased TSA antitumor effects and have a synergistic effect on osteosarcoma cell line proliferation and apoptosis.

 

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[251]

TÍTULO / TITLE:  - Recurrent Dermatofibrosarcoma Protuberans With Pulmonary Metastases Presenting Twelve Years After Initial Diagnosis: 18 F-FDG PET/CT Imaging Findings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Mar 22.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e318279f28e

AUTORES / AUTHORS:  - Suman S; Sharma P; Jain TK; Sahoo MK; Bal C; Kumar R

INSTITUCIÓN / INSTITUTION:  - From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

RESUMEN / SUMMARY:  - Dermatofibrosarcoma protuberans is a rare cutaneous tumor that is locally aggressive and has a high rate of recurrence after surgical excision. The tumor grows slowly, typically over years. On rare occasions, metastasis to distant sites (especially the lung) or regional lymph nodes may occur. Here, we present F-FDG PET/CT imaging findings of a 52-year-old man with a local recurrence of dermatofibrosarcoma protuberans in the anterior abdominal wall with metastases to bilateral lungs.

 

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[252]

TÍTULO / TITLE:  - Rupture of a degenerated uterine fibroid as a cause of acute abdomen: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Reprod Med. 2013 Jan-Feb;58(1-2):72-4.

AUTORES / AUTHORS:  - Takai H; Tani H; Matsushita H

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Shizuoka General Hospital, Shizuoka, Japan.

RESUMEN / SUMMARY:  - BACKGROUND: Uterine fibroid is one of the most common pelvic neoplasms. It is rare for this condition to manifest as acute symptoms necessitating emergency surgical intervention. CASE: A 46-year-old, Japanese woman was referred to our emergency room for sudden epigastric discomfort. A pelvic mass was felt, and computed tomography demonstrated a 13-cm hypodense multilocular cystic mass adjacent to the uterus. The anterior wall of the cyst was thinned and discontinued, suggesting rupture of the cyst. There was also massive ascites. Peritoneal irritation caused by rupture of an ovarian cyst was suspected, and an  emergency exploratory laparotomy was performed. The patient was found to have a distended cystic mass protruding from the posterior surface of the uterus with 3,200 mL of blood-stained ascites. Closer examination revealed a 1-cm tear on the tumor surface, and both solid and cystic parts to the mass. Microscopically the tumor showed a proliferation of myometrial cells without atypia and hyaline degeneration. These findings were interpreted as a rupture of uterine fibroid after cystic degeneration. CONCLUSION: Rupture of degenerated cystic fibroid is rare, but it should be included in the differential diagnosis when encountering patients with a cystic tumor and massive ascites.

 

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[253]

TÍTULO / TITLE:  - Juvenile angiofibroma of the maxillary sinus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Coll Antropol. 2012 Nov;36 Suppl 2:197-9.

AUTORES / AUTHORS:  - Malvic G; Manestar D; Krstulja M; Corak D; Candrlic B; Kujundzic M; Velepic M; Starcevic R

INSTITUCIÓN / INSTITUTION:  - University of Rijeka, Rijeka University Hospital Center, Clinic of Otorhinolaryngology, Head and Neck Surgery, Rijeka, Croatia. goran.malvic@gmail.com

RESUMEN / SUMMARY:  - Juvenile angiofibromas are benign fibro-vascular tumours of the nasopharynx that  develop in prepubertal and adolescent males. Typical symptoms are longstanding unilateral nasal obstruction occasionally followed by epistaxes and frequent severe intraoperative haemorrhage of the discovered mass. We report the case of a 14-year-old boy histologically diagnosed with a juvenile angiofibroma in spite of the atypical localisation of the polyploid mass of the left maxillary sinus.

 

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[254]

TÍTULO / TITLE:  - Congenital Myxoid and Pigmented Dermatofibrosarcoma Protuberans: A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Dermatol. 2013 Mar 28. doi: 10.1111/pde.12131.

            ●● Enlace al texto completo (gratuito o de pago) 1111/pde.12131

AUTORES / AUTHORS:  - El Hachem M; Diociaiuti A; Latella E; Zama M; Lambiase C; Giraldi L; Surrenti T; Callea F

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, Bambino Gesu Children’s Hospital Istituto Di Ricovero  e Cura a Carattere Scientifico, Rome, Italy.

RESUMEN / SUMMARY:  - Dermatofibrosarcoma protuberans (DFSP) is a low-grade, mesenchymal, spindle cell  tumor. In addition to the classical form characterized by a storiform pattern of  tumor cells, pigmented (Bednar’s tumor) and myxoid variants can be observed. Classical DFSP and Bednar’s tumor are easily diagnosed. The myxoid variant represents a diagnostic challenge. Pigmented and myxoid variants are rare and thus far have never been reported in association in congenital DFSP. We came across a unique DFSP that was, at the same time, congenital, pigmented, and myxoid. The tumor was surgically excised with broad free margins and no recurrence. The differential diagnosis with other entities such as giant cell fibroblastoma, CD34-positive plaque-like dermal fibroma, superficial plaque-like  CD34 DFSP, and neurocristic hamartoma is discussed. The recognition of this hybrid variant of congenital DFSP is important to avoid under- or overtreatment.

 

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[255]

TÍTULO / TITLE:  - The levonorgestrel-releasing intrauterine system: its effect on the number of hysterectomies performed in perimenopausal women with uterine fibroids.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gynecol Endocrinol. 2013 May;29(5):492-5. doi: 10.3109/09513590.2013.769517. Epub 2013 Mar 6.

            ●● Enlace al texto completo (gratuito o de pago) 3109/09513590.2013.769517

AUTORES / AUTHORS:  - Machado RB; de Souza IM; Beltrame A; Bernardes CR; Morimoto MS; Santana N

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Jundiai School of Medicine , Jundiai, Sao Paulo , Brazil.

RESUMEN / SUMMARY:  - Abstract This prospective observational study was designed to determine the percentage of hysterectomies avoided following insertion of a levonorgestrel-releasing intrauterine system (LNG-IUS) in perimenopausal women with uterine fibroids and a prior indication for surgery. The study also compared the progress of patients using the LNG-IUS with those submitted to hysterectomy,  with particular emphasis on the patient’s satisfaction with treatment. Sixty perimenopausal patients with uterine fibroids and excessive bleeding referred for hysterectomy were included. After counseling on the possibility of non-surgical treatment, 39 patients opted to use an LNG-IUS while 21 opted for hysterectomy. Continuation of LNG-IUS use and the patient’s satisfaction with the chosen procedure were assessed. A secondary analysis evaluated hemoglobin levels, clinical complications, bleeding patterns and uterine volume at ultrasonography over time. After 24 months of follow-up, four of the patients who had opted to use an LNG-IUS were submitted to surgery, while 35 continued using the device, thus avoiding hysterectomy in 89.5% of cases. LNG-IUS users were more satisfied with treatment (p = 0.02) compared to those submitted to hysterectomy. In conclusion, the use of the LNG-IUS enables the number of hysterectomies to be reduced in women with uterine fibroids and is associated with greater satisfaction compared to surgical treatment.

 

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[256]

TÍTULO / TITLE:  - Low-Grade Fibromyxoid Sarcoma With Cystic Appearance and Osseous Metaplasia in the Cheek: A Case Report and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Maxillofac Surg. 2013 Mar 14. pii: S0278-2391(12)01735-1. doi: 10.1016/j.joms.2012.12.017.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.joms.2012.12.017

AUTORES / AUTHORS:  - He KF; Jia J; Zhao YF

INSTITUCIÓN / INSTITUTION:  - PhD Student, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University; State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan, China.

 

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[257]

TÍTULO / TITLE:  - Sarcomatoid carcinoma represents a complete phenotype with various pathways of epithelial mesenchymal transition.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Pathol. 2013 Mar 26.

            ●● Enlace al texto completo (gratuito o de pago) 1136/jclinpath-2012-201271

AUTORES / AUTHORS:  - Sung CO; Choi H; Lee KW; Kim SH

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

RESUMEN / SUMMARY:  - AIMS: Sarcomatoid carcinoma (SC) is considered to be a result of the sarcomatoid  change of epithelial carcinoma. However, epithelial-mesenchymal transition (EMT)  in SC has been insufficiently studied. METHODS: We evaluated the expression patterns of EMT-related phenotypic markers with transcription factors in 27 SCs originating from various organs, and we investigated the phenotypic characteristics of SCs classified as complete, incomplete or wild-type. We further analysed correlations between EMT-related phenotype markers and transcription factors. RESULTS: Epithelial markers (E-cadherin, claudin-3 and claudin-4) were consistently down-regulated, whereas mesenchymal markers (S100A4, alpha-smooth muscle actin (SMA), vimentin, PDGFRalpha and beta-catenin) were variously expressed except for vimentin. EMT-related transcription factors (SIP1, Snail1, Slug, Twist1, ZEP1 and Oct-4) also showed various expression patterns. The expression patterns of phenotypic markers showed that most SCs (22/27, 81.5%, 95% CI 65.8 to 97.1%) had complete EMT phenotypes, whereas the remaining 5 (18.5%, 95% CI 2.8 to 24.1%) were of incomplete type. Unsupervised hierarchical clustering analysis revealed that SCs were clustered into several subgroups by EMT-related protein expression pattern. Twist1 positivity was significantly concordant with alpha-SMA positivity (kappa value: 0.908; 95% CI 0.73 to 1.00, p<0.001, adjusted p<0.001). The EMT phenotypes of SC were simple, with complete phenotype being the predominant form, and the morphological changes of the SCs were also relevant in terms of EMT. CONCLUSIONS: SC seems to be an irreversible,  permanent change in the EMT phenomenon, with complete EMT phenotypes and various  EMT-related pathways being involved in SC.

 

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[258]

TÍTULO / TITLE:  - Signet Ring Cell Angiosarcoma: A Hitherto Unreported Pitfall in the Diagnosis of  Epithelioid Cutaneous Malignancies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Dermatopathol. 2013 Mar 27.

            ●● Enlace al texto completo (gratuito o de pago) 1097/DAD.0b013e3182892261

AUTORES / AUTHORS:  - Salviato T; Bacchi CE; Luzar B; Falconieri G

INSTITUCIÓN / INSTITUTION:  - *Department of Pathology, General Hospital “S. Maria degli Angeli”, Pordenone, Italy; daggerConsultoria em Patologia, Botucatu, Sao Paulo, Brazil; double daggerInstitute of Pathology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia; and section signDepartment of Pathology, General University  Hospital “S. Maria della Misericordia”, Udine, Italy.

RESUMEN / SUMMARY:  - : We report 2 cases of cutaneous epithelioid angiosarcoma featuring predominantly signet ring cells. The patients-a woman, 68 years of age, and a man, 85 years of  age, respectively-were referred for slowly growing indurated plaques on their parietal and retroauricular skin. Microscopic examination showed diffuse dermal proliferations comprising polygonal cells and relatively abundant cytoplasm. Because the tumor cells often were distended by variably sized vacuoles pushing the nuclei to the periphery, the nuclear profile tended toward a crescent-like morphology. Abortive luminal formations were recognized. The tumor cells were positive for CD31, CD34, and D2-40/podoplanin, with no expression of epithelial or melanocytic markers. In 1 case, upon ultrastructural examination of paraffin-embedded tissue-cut from wax tissue and reprocessed-the optically empty  spaces were surrounded by a membrane with ultrastructural features identical to those of the outer cell membrane, suggesting that these spaces corresponded to the formation of primitive intracytoplasmic lumina within the tumor cells. A few  Weibel-Palade bodies also were noted. Our report offers further evidence that epithelioid angiosarcoma of the skin has a broad microscopic spectrum and that tumors displaying a preponderant population of signet ring cells pose further diagnostic challenges. A brief overview of cutaneous malignant tumors in the differential diagnosis of signet ring cell angiosarcoma is provided.

 

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[259]

TÍTULO / TITLE:  - Diagnostic Utility of Fli-1 and D2-40 in Distinguishing Atypical Fibroxanthoma From Angiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Dermatopathol. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 1097/DAD.0b013e318266b197

AUTORES / AUTHORS:  - Cuda J; Mirzamani N; Kantipudi R; Robbins J; Welsch MJ; Sundram UN

INSTITUCIÓN / INSTITUTION:  - *Department of Pathology, Stanford University Medical Center, Stanford, CA daggerPathology Associates of St. Thomas, Nashville, TN double daggerSkinMD, Orland Park, IL section signDepartment of Dermatology, Stanford University Medical Center, Stanford, CA.

RESUMEN / SUMMARY:  - : Although in most cases one can easily distinguish between atypical fibroxanthomas and angiosarcomas, hemorrhagic atypical fibroxanthomas can pose a  diagnostic problem. In rare cases, the large atypical cells of atypical fibroxanthoma can stain with CD31, leading to the erroneous diagnosis of angiosarcoma. We elected to further study this conundrum with 2 additional markers of lymphatic and vascular elements, namely D2-40 (podoplanin) and Fli-1,  respectively. We studied 26 cases of atypical fibroxanthoma and 20 cases of angiosarcoma with Fli-1 and D2-40. We found that both Fli-1 and D2-40 stained a majority of cases of angiosarcoma (16/20 and 12/20, respectively), although only  staining a minority of cases of atypical fibroxanthoma (8/26 for both). In addition, D2-40 staining of atypical fibroxanthoma was usually weak when positive, whereas Fli-1 staining of angiosarcomas was mostly strong and nuclear.  Thus, both D2-40 and Fli-1 seem to be useful in distinguishing between atypical fibroxanthomas and angiosarcomas.

 

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[260]

TÍTULO / TITLE:  - Alveolar Soft-Part Sarcoma of the Orbit: Report of 2 Cases With Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ophthal Plast Reconstr Surg. 2013 Mar 25.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IOP.0b013e318281ecb9

AUTORES / AUTHORS:  - Kim HJ; Wojno T; Grossniklaus HE; Shehata BM

INSTITUCIÓN / INSTITUTION:  - *Departments of Ophthalmology and daggerPathology, Emory University School of Medicine, Atlanta, Georgia, U.S.A.

RESUMEN / SUMMARY:  - Alveolar soft-part sarcoma (ASPS) is a translocation-associated sarcoma that occurs most commonly in the lower extremities and rarely in orbit. Only 34 orbital cases have been reported in the literature, and it is often misdiagnosed  due to its rare occurrence and nonspecific clinical findings. The optimal treatment remains controversial, although in general, aggressive surgical resection is advocated. Here, the authors present 2 cases of orbital ASPS and a review of the literature.

 

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[261]

TÍTULO / TITLE:  - Hysteroscopic Enucleation of Type II Submucosal Uterine Leiomyomas Using a TRUCLEAR Hysteroscopic Morcellator: Case Report and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Laparoendosc Adv Surg Tech A. 2013 Mar 11.

            ●● Enlace al texto completo (gratuito o de pago) 1089/lap.2012.0425

AUTORES / AUTHORS:  - Pakrashi T; Ressler IB; Sroga JM; Dipaola KB; Thomas MA; Lindheim SR

INSTITUCIÓN / INSTITUTION:  - 1 Department of Obstetrics and Gynecology, Eastern Virginia Medical School , Norfolk, Virginia.

RESUMEN / SUMMARY:  - Abstract Objective: We describe a case of complete enucleation of a Type II leiomyoma using the TRUCLEAR (Smith & Nephew Endoscopy, Andover, MA) hysteroscopic morcellator (THM) and demonstrate appropriate preoperative assessment and intraoperative surgical principles during this case. Complete hysteroscopic enucleation of Type II leiomyomas is also systematically reviewed.  Materials and Methods: In this case report and review, performed in a tertiary-care university setting, the THM was used for hysteroscopic resection of two submucosal leiomyomas. Results: A 41-year-old gravida 1 para 0010 presented with infertility and symptomatic leiomyomas. Preoperative assessment included a hysterosalpingogram, magnetic resonance imaging, and sonohysterography demonstrating several extrinsic impressions on the uterine cavity and two submucosal leiomyomas (Type I and Type II). Diagnostic hysteroscopy confirmed findings. As the THM blade started resecting the Type II leiomyoma, it began to separate from the underlying myometrium. Attempts to release the edge of the leiomyoma, including reverse rotation of the blade, completely enucleated the leiomyoma, which was subsequently removed from the cavity with the THM. Minimal bleeding was encountered; intraoperative ultrasound confirmed normal overlying myometrium. Postoperatively, sonohysterography showed complete closure of the dead space with only a slightly distorted endometrial cavity. Conclusions: Hysteroscopic uterine leiomyoma enucleation should only be performed in experienced hands. Inadvertent enucleation of a Type II leiomyoma with a THM device is described, with review of key surgical principles that guided safe resection.

 

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[262]

TÍTULO / TITLE:  - A “complicated” fracture: a Philadelphia chromosome-positive myeloid sarcoma of the bone.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Hematol. 2013 Feb 13.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00277-013-1691-7

AUTORES / AUTHORS:  - van Groningen LF; Preijers FW; Jansen JH; Hebeda KM; van der Velden WJ

INSTITUCIÓN / INSTITUTION:  - Department of Hematology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500, HB, Nijmegen, the Netherlands, l.vangroningen@aig.umcn.nl.

 

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[263]

TÍTULO / TITLE:  - Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma: characterization  of five cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Skeletal Radiol. 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00256-013-1577-8

AUTORES / AUTHORS:  - Amary MF; O’Donnell P; Berisha F; Tirabosco R; Briggs T; Pollock R; Flanagan AM

INSTITUCIÓN / INSTITUTION:  - Departments of Histopathology, Radiology and Surgery, Royal National Orthopaedic  Hospital NHS trust, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK.

RESUMEN / SUMMARY:  - OBJECTIVE: To describe the imaging and histopathology of pseudomyogenic hemangioendothelioma. MATERIALS AND METHODS: Five cases of pseudomyogenic hemangioendothelioma, which presented over the last 5 years, were retrieved from  the files of the Royal National Orthopaedic Hospital. The imaging and histopathology were reviewed in all cases. Magnetic resonance imaging, which was  available from all cases, was assessed for the following features: the number of  lesions, location in soft tissue (superficial and or deep/subfascial) and bone, and the signal characteristics and morphology of individual lesions. Immunohistochemistry was performed in all cases to characterize the lesions. RESULTS: Four of the five patients had multiple lesions involving a single limb.  Bone was involved in 3 of the 5 individuals. All tumors diffusely expressed ERG and cytokeratins AE1/3, but not MNF116. CD31 was weakly positive in 4 cases. INI-1 expression was retained in all cases. Imaging features included ill-defined, infiltrative lesions in subcutaneous fat with extension to the adjacent skin, poor- to well-defined intramuscular nodules and predominantly intracortical focal bone lesions with rare medullary involvement. CONCLUSION: Pseudomyogenic hemangioendothelioma represents a distinct recently characterized  tumor type presenting in young adults, with a tendency towards multicentric bone  and soft tissue involvement.

 

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[264]

- CASTELLANO -

TÍTULO / TITLE:Angiomiolipoma nasal.

TÍTULO / TITLE:  - Nasal angiomyolipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Otorrinolaringol Esp. 2013 Feb 20. pii: S0001-6519(12)00261-0. doi: 10.1016/j.otorri.2012.10.005.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.otorri.2012.10.005

AUTORES / AUTHORS:  - Ibanez Rodriguez JA; Segura Sanchez J; Gomez Galan MJ; Garcia-Eloy Carrasco C

INSTITUCIÓN / INSTITUTION:  - Servicio de Otorrinolaringologia, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla, España. Electronic address: juanantonio_ibanez_rodriguez@hotmail.com.

 

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[265]

- CASTELLANO -

TÍTULO / TITLE:Sarcoma de celulas foliculares dendriticas de la amigdala.

TÍTULO / TITLE:  - Follicular dendritic cell sarcoma of the tonsil.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Otorrinolaringol Esp. 2013 Feb 14. pii: S0001-6519(12)00259-2. doi: 10.1016/j.otorri.2012.11.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.otorri.2012.11.001

AUTORES / AUTHORS:  - Ribeiro L; Lima N; Almeida A; Conde A

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology, Vila Nova de Gaia/Espinho Hospital, Vila Nova  de Gaia, Portugal.

 

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[266]

TÍTULO / TITLE:  - Littoral Cell Angiosarcoma in a Dog.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Comp Pathol. 2013 Feb 28. pii: S0021-9975(13)00017-0. doi: 10.1016/j.jcpa.2013.01.003.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcpa.2013.01.003

AUTORES / AUTHORS:  - Gal A; Yamate J; Golbar HM; Spoerer K; Fredrickson R

INSTITUCIÓN / INSTITUTION:  - University of Illinois, College of Veterinary Medicine, Department of Pathobiology, Urbana, IL 61802, USA. Electronic address: agal2@illinois.edu.

RESUMEN / SUMMARY:  - This report describes the microscopical and immunohistochemical characteristics of littoral cell angiosarcoma in a 12-year-old, neutered female, beagle dog. The  dog succumbed to metastatic disease 3 months after diagnosis of a mid-splenic mass. The tumour was characterized by two histological patterns: anastomosing microvascular channels and microvascular papillary fronds. The neoplastic cells expressed both endothelial and histiocytic markers and were erythrophagocytic. Immunohistochemical findings consistent with malignancy were CD34 expression and  high Ki67 nuclear immunoreactivity.

 

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[267]

TÍTULO / TITLE:  - Minnelide reduces tumor burden in preclinical models of osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Lett. 2013 Mar 14. pii: S0304-3835(13)00213-9. doi: 10.1016/j.canlet.2013.02.050.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.canlet.2013.02.050

AUTORES / AUTHORS:  - Banerjee S; Thayanithy V; Sangwan V; Mackenzie TN; Saluja AK; Subramanian S

INSTITUCIÓN / INSTITUTION:  - Division of Basic and Translational Research, Department of Surgery, University of Minnesota, United States.

RESUMEN / SUMMARY:  - Osteosarcoma is the most common bone cancer in children and adolescents with a 5-year survival rate of about 70%. In this study, we have evaluated the preclinical therapeutic efficacy of the novel synthetic drug, Minnelide, a prodrug of triptolide on osteosarcoma. Triptolide was effective in significantly  inducing apoptosis in all osteosarcoma cell lines tested but had no significant effect on the human osteoblast cells. Notably, Minnelide treatment significantly  reduced tumor burden and lung metastasis in the orthotopic and lung colonization  models. Triptolide/Minnelide effectively downregulated the levels of pro-survival proteins such as heat shock proteins, cMYC, survivin and targets NF-kappaB pathway.

 

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[268]

TÍTULO / TITLE:  - First identification of Ewing’s sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biol Cell. 2013 Mar 22. doi: 10.1111/boc.201200086.

            ●● Enlace al texto completo (gratuito o de pago) 1111/boc.201200086

AUTORES / AUTHORS:  - Miller IV; Raposo G; Welsch U; Prazeres da Costa O; Thiel U; Lebar M; Maurer M; Bender HU; von Luettichau I; Richter GH; Burdach S; Grunewald TG

INSTITUCIÓN / INSTITUTION:  - Children’s Cancer Research Center and Roman Herzog Comprehensive Cancer Center, Department of Pediatrics, Klinikum rechts der Isar, Technische Universitat Munchen, Kolner Platz 1, 80804 Munich, Germany.

RESUMEN / SUMMARY:  - BACKGROUND INFORMATION: Exosomes are small RNA- and protein-containing extracellular vesicles that are thought to mediate hetero- and homotypic intercellular communication between normal and malignant cells. Tumor-derived exosomes are believed to promote reprogramming of the tumor-associated stroma to  favor tumor growth and metastasis. Currently, exosomes have been intensively studied in carcinomas. However, little is known about their existence and possible role in sarcomas. RESULTS: Here, we report on the identification of vesicles with exosomal features derived from Ewing’s sarcoma (ES), the second most common soft-tissue or bone cancer in children and adolescents. ES cell line-derived extracellular vesicles have been isolated by ultracentrifugation and analyzed by flow-cytometric assessment of the exosome-associated proteins CD63 and CD81 as well as by electron microscopy. They proved to contain ES-specific transcripts including EWS-FLI1, which were suitable for the sensitive detection of ES cell line-derived exosomes by qRT-PCR in a preclinical model for patient plasma. Microarray analysis of ES cell line-derived exosomes revealed that they share a common transcriptional signature potentially involved in G-protein-coupled signaling, neurotransmitter signaling, and stemness. CONCLUSIONS: In summary, our results imply that ES-derived exosomes could eventually serve as biomarkers for minimal residual disease diagnostics in peripheral blood and prompt further investigation of their potential biological role in modification of the ES-associated microenvironment.

 

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[269]

TÍTULO / TITLE:  - Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastroenterol. 2013 Jan 28;19(4):523-7. doi: 10.3748/wjg.v19.i4.523.

            ●● Enlace al texto completo (gratuito o de pago) 3748/wjg.v19.i4.523

AUTORES / AUTHORS:  - Belev B; Brcic I; Prejac J; Golubic ZA; Vrbanec D; Bozikov J; Aleric I; Boban M; Razumovic JJ

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Clinic of Oncology, Clinical Hospital Center Zagreb, 10000 Zagreb, Croatia. borislavbelev@gmail.com

RESUMEN / SUMMARY:  - AIM: To investigate primarily the prognostic value of Ki-67, as well as other parameters, in gastrointestinal stromal tumors (GISTs). METHODS: Ki-67, c-KIT, platelet-derived growth factor receptor-alpha (PDGFRalpha), smooth muscle actin (SMA), CD34, S100 were stained for immunohistochemistry which was performed on formalin-fixed, paraffin-embeded sections on representative block from each case. Proliferation index counted by Ki-67 antibody was calculated as a number of positive nuclear reaction over 100 cells. Immunoreactivity for c-KIT and PDGFRalpha was evaluated semiquantitatively (weak, intermediate, strong) and for  c-KIT type of reactivity was analyzed (cytoplasmic, membrane and “dot-like” staining). Immunoreactivity for SMA, CD34 and S100 were was evaluated as positive or negative antigen expression. Pathologic parameters investigated in this study  included tumor size, cell type (pure spindle, pured epitheloid mixed spindle and  epitheloid), mitotic count, hemorrhage, necrosis, mucosal ulceration. Clinical data included age, gender, primary tumor location and spread of disease. chi(2) test and Student’s t-test were used for comparisons of baseline characteristics.  The Cox’s proportional hazard model was used for univariable and multivariable analyses. Survival rates were calculated by Kaplan-Meier method and statistical significance was determined by the log-rank test. RESULTS: According to the stage of disease, there were 36 patients with localized disease, 29 patients with initially localized disease but with its recurrence in the period of follow up, and finally, 35 patients had metastatic disease from the very beginning of disease. Tumor originated most commonly in the stomach (41%), small intestine was the second most common location (36%). The mean size of primary tumors was 6.5 cm. The mean duration of follow-up was 60 mo. Multiple parameters were analyzed for their effect on overall survival, but no one reached statistical significance (P = 0.06). Analysis of time to progression/relapse in initially localized disease (univariate analysis), tumor size, mitotic count, Ki-67 and type of d-KIT distribution (cytoplasmic vs membrane/”dot-like”) showed statistically significant correlation. In multivariate analysis in the group of patients with localized disease, there were only 2 parameters that have impact on relapse, Ki-67 and SMA (P < 0.0001 and P < 0.034, respectively). Furthermore, Ki-67 was analyzed in localized disease vs localized with recurrence and metastatic disease. It was shown that there is a strict difference between these 2 groups of patients (median value was 2.5 for localized disease vs 10.0 for recurrent/metastatic disease, P < 0.0001). It was also shown that the cut-off value which is still statistically significant in terms of relapse on the level of 6%. The curves for survival on that cut-off level are significantly different  (P < 0.04, Cox F). CONCLUSION: Ki-67 presents a significant prognostic factor for GIST recurrence which could be of great importance in evaluating malignant potential of disease.

 

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[270]

TÍTULO / TITLE:  - C86Y: as a Destructive Homozygous Mutation Deteriorating Pex7p Function Causing Rhizomelic Chondrodysplasia Punctata Type I.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Clin Lab Sci. 2013 Winter;43(1):76-80.

AUTORES / AUTHORS:  - Salamian A; Mohamadynejad P; Ghaedi K; Nejati AS; Shafeghati Y; Ahnak MB; Nematollahi M; Karbalaie K; Hadipour F; Baharvand H; Nasr-Esfahani MH

INSTITUCIÓN / INSTITUTION:  - Department of Cell and Molecular Biology, Cell Science research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran; e mails: kamranghaedi@royaninstitute.org.

RESUMEN / SUMMARY:  - Rhizomelic Chondrodysplasia Punctata (RCDP) type 1 is a peroxisomal biogenesis disorder with a genetic abnormality in PEX7 gene. In the present study, mutational analysis was performed on two Iranian RCDP patients with distinct clinical phonotype. Mutation detection was carried out by sequencing of RT-PCR product consisting the whole length of PEX7 cDNA. Sequence data revealed the same missense homozygous mutation of G to A at nucleotide 257 in exon3 of PEX7 coding  sequence in both patients. Moreover, genomic analysis of the PEX7 gene confirmed  the RT-PCR data. This mutation caused one amino acid residue substitution of Cys  to Tyr at codon 86 located on WD1 repeat domain region of Pex7p, which severely affected the functionality of PEX7 protein. Back-transfection of vector encoding  mutant Pex7p did not restore the normal peroxisomal function in RCDP patient’s fibroblast cells dissimilar to the native type of PEX7.

 

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[271]

TÍTULO / TITLE:  - Chondrosarcoma of the Subglottic Larynx: Submucosal Microdissection With the Operating Microscope.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Laryngoscope. 2013 Feb 12. doi: 10.1002/lary.23957.

            ●● Enlace al texto completo (gratuito o de pago) 1002/lary.23957

AUTORES / AUTHORS:  - Jackson RS; Leon ME; McCaffrey TV

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology, University of South Florida College of Medicine, Tampa, FL; H. Lee Moffitt Cancer Center, Tampa, FL.

RESUMEN / SUMMARY:  - OBJECTIVES/HYPOTHESIS: Chondrosarcoma is a rare malignancy of the head and neck with fewer than 600 cases described in the literature. Treatment typically consists of conservation surgery with preservation of airway and preoperative voice quality. We describe five patients treated with a conservative transcervical approach utilizing the operating microscope for submucosal microdissection. STUDY DESIGN: Retrospective case series at a National Cancer Institute-designated comprehensive cancer center. METHODS: A retrospective case series from February 2004 to February 2011 was performed for all consecutive patients with laryngeal chondrosarcoma treated by the senior author with transcervical submucosal microdissection utilizing the operating microscope. RESULTS: Five patients with laryngeal chondrosarcoma were treated between February 2004 and February 2011. There were three male and two female patients who ranged in age from 56 to 87 years (mean, 72 years) at presentation. All five  tumors were located at the level of the cricoid cartilage. Hoarseness was the most common presenting symptom (60%). Eighty percent of patients had limited vocal cord mobility. No patients required neck dissection or received radiation or chemotherapy. None of the five patients had recurrence after this approach. CONCLUSIONS: Laryngeal chondrosarcoma is a rare tumor. Conservative surgical resection remains the mainstay of treatment. The use of an operating microscope can aid in successful resection of laryngeal chondrosarcoma while preserving laryngeal mucosa and function. LEVEL OF EVIDENCE: 4. Laryngoscope, 2013.

 

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[272]

TÍTULO / TITLE:  - Lipomas of the cerebellopontine angle and internal auditory canal: Primum Non Nocere.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Laryngoscope. 2013 Feb 9. doi: 10.1002/lary.23882.

            ●● Enlace al texto completo (gratuito o de pago) 1002/lary.23882

AUTORES / AUTHORS:  - White JR; Carlson ML; Van Gompel JJ; Neff BA; Driscoll CL; Lane JI; Link MJ

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First Street S.W., Rochester, Minnesota, U.S.A.

RESUMEN / SUMMARY:  - OBJECTIVES/HYPOTHESIS: To describe the presentation and clinical course of cerebellopontine angle (CPA) and internal auditory canal (IAC) lipomas. STUDY DESIGN: Retrospective cohort study at a tertiary academic referral center. METHODS: All patients presenting with a CPA or IAC mass radiographically consistent with a lipoma on high-resolution magnetic resonance imaging (MRI) were identified. Data including presenting symptomatology, tumor characteristics, management strategy, and patient course were collected. RESULTS: Between 1996 and 2012, 15 patients were diagnosed with a CPA or IAC lipoma at the authors’ institution and were included in the analysis. The mean duration of radiological  and clinical follow-up was 3.4 years and 5.1 years, respectively. Eight lesions were confined to the IAC, while seven involved the CPA. The median tumor size at  diagnosis was 7.2 mm; one patient demonstrated tumor growth on serial MRI while the remaining subjects did not have radiological progression. The most common presenting symptoms were sensorineural hearing loss (40%) and tinnitus (33%); five patients were diagnosed after incidental discovery on MRI. Fourteen patients were managed with observation, while one subject underwent subtotal resection. None of the observed patients reported worsening symptoms at last follow-up. CONCLUSIONS: While rare, lipomas should be included in the differential diagnosis of CPA and IAC lesions. Owing to a generally benign clinical course and high morbidity associated with resection, microsurgery should only be considered in cases of definite tumor enlargement with intractable symptoms from mass effect. Careful radiological evaluation is critical for establishing an accurate diagnosis in order to prevent unnecessary morbidity associated with resection. LEVEL OF EVIDENCE: 2b.

 

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[273]

TÍTULO / TITLE:  - Intermittent and continuous imatinib in a human GIST xenograft model carrying KIT exon 17 resistance mutation D816H.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Oncol. 2013 Mar 13.

            ●● Enlace al texto completo (gratuito o de pago) 3109/0284186X.2013.770920

AUTORES / AUTHORS:  - Revheim ME; Kristian A; Malinen E; Bruland OS; Berner JM; Holm R; Joensuu H; Seierstad T

INSTITUCIÓN / INSTITUTION:  - Department of Radiology and Nuclear Medicine, Oslo University Hospital , Nydalen, Oslo , Norway.

RESUMEN / SUMMARY:  - Background. Acquired resistance to imatinib is frequently caused by secondary KIT mutations. We have investigated the effects of imatinib in mice with human gastrointestinal stromal tumour (GIST) xenograft which harbours a primary exon 11 deletion mutation and a secondary imatinib resistance mutation D816H in exon 17.  Such mutations are commonly present in imatinib-resistant GIST in humans. Material and methods. The mice were randomly allocated to receive imatinib either continuously or intermittently. Dynamic 18F-FDG PET was performed and blood volume fraction (vB), rate transfer constants (k1, k2, k3) and metabolic rate of  18F-FDG (MRFDG) were computed using a three-compartment model. Tumours were evaluated for the mitotic rate and the expression of HIF-1alpha , caspase-3 and glucose transporters (GLUTs). Results. Both intermittent and continuous imatinib  delayed tumour growth significantly compared to controls, significantly in favour of the latter. k1 (representing perfusion, vascular permeability and binding of 18F-FDG to the GLUTs) was significantly higher in the intermittent group compared to the continuous group, as was tumour GLUT-3 expression. k3 (representing internalisation of 18F-FDG to the cells) and MRFDG were significantly lower. Conclusion. Imatinib delays GIST xenograft growth despite the presence of the D816H resistance mutation. The schedule of imatinib administration may influence  tumour glucose uptake rate and metabolic rate.

 

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[274]

TÍTULO / TITLE:  - Radiologic case study. Neurofibroma causing tarsal tunnel syndrome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orthopedics. 2013 Feb;36(2):81, 154-7. doi: 10.3928/01477447-20130122-01.

            ●● Enlace al texto completo (gratuito o de pago) 3928/01477447-20130122-01

AUTORES / AUTHORS:  - Mirick AL; Bornstein GB; Bancroft LW

INSTITUCIÓN / INSTITUTION:  - University of Central Florida College of Medicine, Florida Hospital, Orlando, Florida, USA.

 

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[275]

TÍTULO / TITLE:  - When a thymic carcinoma “becomes” a GIST.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Lung Cancer. 2013 Apr;80(1):106-8. doi: 10.1016/j.lungcan.2013.01.003. Epub 2013  Feb 1.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.lungcan.2013.01.003

AUTORES / AUTHORS:  - Rossi V; Donini M; Sergio P; Passalacqua R; Rossi G; Buti S

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Istituti Ospitalieri of Cremona, Italy. Electronic address: valentina.rossi@ircc.it.

RESUMEN / SUMMARY:  - Thymic carcinoma (TC) is a rare intrathoracic malignancy that it can be invasive  and refractory to conventional treatment. Comprehensive genomic analysis evidenced a molecularly distinct subset of thymic carcinoma with high prevalence  of c-kit mutation, which may behave as a gastrointestinal stromal tumor (GIST). Here, we present a case report of TC with c-Kit mutation, who has relapsed after  exposure to multiple lines of combination chemotherapy, but he has shown an impressive and long lasting response to sunitinib after imatinib failure.

 

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[276]

TÍTULO / TITLE:  - Can HMGI-C be used as an aid with MDM2 and CDK4 to differentiate liposarcoma subtypes from their mimics?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cancer Res Clin Oncol. 2013 Mar 26.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00432-013-1420-6

AUTORES / AUTHORS:  - Alshenawy H

INSTITUCIÓN / INSTITUTION:  - , Tanta, Egypt, hanan_alshenawy@yahoo.com.

RESUMEN / SUMMARY:  - PURPOSE: Liposarcoma represents the most common soft tissue tumors in adults. The tumors are characterized by a high morphological diversity and a great variation  in biological behavior. Atypical lipomatous tumors represent a distinctive subset of mesenchymal neoplasms featuring mature adipocytic differentiation. Histologically, atypical lipomatous tumor might be easily confused with lipoma. Conversely, dedifferentiated liposarcoma may be confused with other spindle cell/pleomorphic undifferentiated tumors. METHODS: A group of liposarcomas was analyzed by investigating the MDM2, CDK4, and HMGI-C proteins. The study was extended to a group of lipomas and non-lipomatous sarcomas, to determine whether  the immunohistochemical investigation of these proteins might play any diagnostic role. RESULTS: Our data suggest that ordinary lipomas may form a molecular genetic and morphological continuum with atypical lipomatous tumor. At one end of the spectrum are lipomas characterized by HMGI-C activation and at the other end  are atypical lipomatous tumors with overrepresentation of the HMGI-C, CDK4, or MDM2 proteins. These findings not only provide insights into the molecular pathogenesis of lipomatous tumors, but also indicate that the immunohistochemical analysis of HMGI-C, CDK4, or MDM2 may help to increase diagnostic accuracy. CONCLUSIONS: HMGI-C is a useful adjunct in the diagnosis of atypical lipomatous tumor and dedifferentiated liposarcoma and differentiates them from their mimics. Therefore, in our experience, HMGI-C expression alone is of rather limited value  in the differential diagnosis of liposarcoma subtypes.

 

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[277]

TÍTULO / TITLE:  - A Case of Concomitant Occurrence of Solitary Fibrous Tumor and Urothelial High-Grade Invasive Carcinoma of the Urinary Bladder.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Pathol. 2013 Mar 19.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1066896913481061

AUTORES / AUTHORS:  - Spairani C; Squillaci S; Pitino A; Ferrari M; Montefiore F; Rossi C; Fusco W; Bigatti GL

RESUMEN / SUMMARY:  - Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm, most commonly arising from the pleura. It has also been recently described to occur in extrapleural sites. To our knowledge, only 16 cases of SFT have been reported in  the urinary bladder to date. We report the clinicopathological features of a vesical SFT occurring in a 60-year-old man who presented a concomitant invasive high-grade urothelial cell carcinoma. No similar association has been found in the accessible literature. The morphologic and immunohistochemical clues leading  to the correct diagnosis of SFT have been correlated with the data of the literature, and the differential diagnosis is briefly discussed.

 

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[278]

TÍTULO / TITLE:  - Hibernoma: comparing imaging appearance with more commonly encountered benign or  low-grade lipomatous neoplasms.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Skeletal Radiol. 2013 Feb 6.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00256-013-1583-x

AUTORES / AUTHORS:  - Liu W; Bui MM; Cheong D; Caracciolo JT

INSTITUCIÓN / INSTITUTION:  - Department of Sarcoma, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA, liuweifengjst@126.com.

RESUMEN / SUMMARY:  - OBJECTIVE: Hibernoma is a benign neoplasm comprised of brown fat and characteristic hibernoma cells often occurring in adults with proximal extremity/truncal predilection. Limited reports regarding imaging appearance and  clinicopathological features of this rare tumor are available. Four histological  subtypes have been described. We present nine patients with hibernoma evaluating  preoperative imaging findings (eight MRI; one PET, CT), which may distinguish hibernoma from more common benign or low-grade lipomatous neoplasms and attempt to correlate imaging with histological subtype. Clinicopathological data of 14 patients are presented. MATERIALS AND METHODS: Following IRB approval, retrospective review identified 14 patients from our institution between 2000 and 2012. Preoperative imaging, pathology, and medical records were reviewed. We tested the reader’s ability to distinguish hibernoma from lipoma and atypical lipomatous tumor (ALT) at preoperative MRI based on specific imaging criteria. In a separate test, another reader attempted to predict histological subtype. Diagnostic accuracy was recorded. RESULTS: Six men and eight women with a mean age of 53 years were identified. Tumors involved the thigh (4), buttock (3), paraspinal muscles (3), retroperitoneum (2), shoulder (1), and knee (1). Eleven underwent margin negative resection; three excisional biopsy. When asked to differentiate hibernoma from lipoma and ALT, readers correctly identified 80 %, 80 %, and 100 % of hibernomas. Specific histological subtype was accurately predicted in most cases. Mean follow-up was 38 months with no local recurrences or metastases. CONCLUSIONS: Hibernomas can be difficult to differentiate from other lipomatous neoplasms, but identification of certain imaging features, common location, and patient demographics can improve preoperative confidence. Given benignity, accurate prospective diagnosis may affect treatment planning and surveillance strategy.

 

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[279]

TÍTULO / TITLE:  - Recurrent cotyledonoid dissecting leiomyoma of the uterus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Gynecol Pathol. 2013 Mar;32(2):215-20. doi: 10.1097/PGP.0b013e318257dff4.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PGP.0b013e318257dff4

AUTORES / AUTHORS:  - Roth LM; Kirker JA; Insull M; Whittaker J

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Indiana University School of Medicine, Indianapolis, IN  46202-5120, USA. lroth@iupui.edu

RESUMEN / SUMMARY:  - Cotyledonoid dissecting leiomyoma is a benign smooth muscle neoplasm with an unusual growth pattern that is characterized by intramural dissection within the  uterine corpus and often a placental-like appearance macroscopically in its extrauterine component that may be alarming to the surgeon. All cases reported to date have been nonaggressive. We report a case in a 33-yr-old woman who had a history of prolonged uterine bleeding. She was operated upon for uterine leiomyomas, and the diagnosis of cotyledonoid dissecting leiomyoma was made at the time of intraoperative consultation. To maintain fertility, the intrauterine  tumor was resected by myomectomy and the extrauterine tumor by excision. However, persistent uterine bleeding that eventually became intractable and continued growth of the neoplasm in the uterus necessitated hysterectomy 5 yr later. She was living and well 2.5 yr after hysterectomy with no evidence of disease.

 

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[280]

TÍTULO / TITLE:  - Myeloid Sarcoma of the Head and Neck Region.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Pathol Lab Med. 2013 Mar 26.

            ●● Enlace al texto completo (gratuito o de pago) 5858/arpa.2012-0537-OA

AUTORES / AUTHORS:  - Zhou J; Bell D; Medeiros LJ

INSTITUCIÓN / INSTITUTION:  - From the Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston.

RESUMEN / SUMMARY:  - Context.-Myeloid sarcoma of the head and neck region can pose diagnostic challenges because of the low frequency of myeloid sarcoma and the potential for  tumors of almost any lineage to occur in the head and neck. Objective.-To study the clinicopathologic and immunohistochemical characteristics of myeloid sarcoma  in the head and neck region and to review the differential diagnosis. Design.-We  searched for cases of myeloid sarcoma involving the head and neck region for a 24-year period at our institution. The medical records and pathology slides were  reviewed. Additional immunohistochemical stains were performed. Results.-We identified 17 patients, age 17 to 85 years. Most tumors involved the oral cavity. Myeloid sarcoma was the initial diagnosis in 9 patients (53%); the remaining 8 patients (47%) had a history of bone marrow disease. Immunohistochemical analysis using antibodies specific for lysozyme, CD43, and CD68 were highly sensitive for  diagnosis but were not specific. By contrast, assessment for myeloperoxidase in this study was less sensitive but more specific. We also used antibodies specific for CD11c and CD33 in a subset of cases, and these reagents seem helpful as well. Conclusions.-The clinical presentation of myeloid sarcoma involving the head and  neck, particularly the mouth, is often nonspecific, and a high degree of suspicion for the possibility of myeloid sarcoma is needed. Immunohistochemistry  is very helpful for establishing the diagnosis.

 

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[281]

TÍTULO / TITLE:  - Acral myxoinflammatory fibroblastic sarcoma: cytopathologic findings on fine-needle aspiration.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Cytol. 2013;57(2):134-8. doi: 10.1159/000345901. Epub 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000345901

AUTORES / AUTHORS:  - Toll AD; Wakely PE Jr; Ali SZ

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA.

RESUMEN / SUMMARY:  - BACKGROUND: Acral myxoinflammatory fibroblastic sarcoma (AMFS) is a rare low-grade sarcoma with somewhat unique morphologic characteristics. While recurrences are relatively common, distant metastases are infrequent. Cytopathologic descriptions of AMFS are limited, prompting the current study. METHODS: A retrospective review was performed at two tertiary-care hospitals, and 3 patients with this diagnosis were identified. The cytopathologic and clinical features were reviewed. The following clinical data was collected for each case:  age, gender, site of lesion, treatment, and follow-up information. RESULTS: Pertinent cytologic features included large atypical epithelioid cells with occasional macronucleoli and lipoblast-like features in a background of bland spindle cells, myxoid stroma, and inflammation. All patients presented with acral mass lesions. Metastatic disease to an inguinal lymph node was found in 1 patient. CONCLUSIONS: AMFS is a low-grade sarcoma which shows some characteristic cytologic features. However, due to the presence of occasional bizarre and pleomorphic giant cells, there can be overlap with higher-grade sarcomas, and correlation with histology, immunohistochemistry, and imaging are required to make this diagnosis.

 

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[282]

TÍTULO / TITLE:  - Perivascular epithelioid cell tumor located retroperitoneally with pulmonary lymphangioleiomyomatosis: report of a case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Surg Today. 2013 Mar 21.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00595-013-0541-5

AUTORES / AUTHORS:  - Pata G; Tironi A; Solaini L; Tiziano T; Ragni F

INSTITUCIÓN / INSTITUTION:  - 2nd Division of General Surgery, Department of Medical and Surgical Sciences, Brescia Civic Hospital, P.le Spedali Civili 1, 25124, Brescia, Italy, giacomopata@alice.it.

RESUMEN / SUMMARY:  - Perivascular epithelioid cell neoplasms, also known as “PEComas”, are unusual mesenchymal tumors, exhibiting perivascular epithelioid cell differentiation and  characterized by a mixed myogenic and melanocytic phenotype. “PEComas not otherwise specified” (PEComas-NOS) are especially rare; consequently, there are no published large series, but only case reports. These tumors are rarely located retroperitoneally, with only about 15 such cases reported. We report a case of pulmonary diffuse lymphangioleiomyomatosis with large retroperitoneal PEComa-NOS  in a 66-year-old woman. Treatment consisted only of tumor resection, without additional adjuvant therapy. We emphasize the importance of correct immunohistochemistry diagnosis, initiation of recommended treatment, and surveillance of this unique family of tumors.

 

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[283]

TÍTULO / TITLE:  - Perplexing imaging manifestations of multiple metastatic intracranial lesions associated with atrial myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniofac Surg. 2013 Mar;24(2):651-2. doi: 10.1097/SCS.0b013e318264690f.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SCS.0b013e318264690f

AUTORES / AUTHORS:  - Zhan R; Ji T; Fan Z; Pan D

INSTITUCIÓN / INSTITUTION:  - From the Department of Neurosurgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, China.

RESUMEN / SUMMARY:  - Neurological manifestations of atrial myxomas may be encountered in different pathological circumstances: cerebral embolism, intracranial aneurysms, and metastatic mass lesions. We report a case of multiple metastatic intracranial lesions associated with atrial myxoma and discuss the potential mechanisms of its perplexing neuroimaging manifestations. Comparing with previous reports of myxoma-associated intracranial lesions, the most notable features of the present  case were the multiple high-density “calcified” lesions accompanying the aneurysms on computed tomography scan and the significant contrast-enhanced mass  in the left parietal lobe on magnetic resonance scan. This suggested an extremely rare case of coexistence of aneurysms and intracranial metastatic mass lesion associated with cardiac myxoma, although the pathological evidence was not available.

 

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[284]

TÍTULO / TITLE:  - Bilateral Adrenal Myelolipomas in a Woman With Chronic Anticoagulation, Postmenopausal Uterine Bleeding, Primary Hyperparathyroidism, and Hyperthyroidism.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Med Sci. 2013 Feb 19.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MAJ.0b013e3182804a87

AUTORES / AUTHORS:  - Saunders RN; Koch CA; Brown KB; Hairston FJ; Daley WP; Ahmed N; Vanderlan WB

INSTITUCIÓN / INSTITUTION:  - Division of Trauma, Surgical Critical Care and Acute Care Surgery, Department of  Surgery (RNS, NA, WBV), University of Mississippi Medical Center, Jackson, Mississippi; and Department of Medicine/Endocrinology (CAK), University of Mississippi Medical Center, Jackson, Mississippi; Cancer Institute (CAK), University of Mississippi Medical Center, Jackson, Mississippi; GV Sonny Montgomery VA Medical Center (CAK), Jackson, Mississippi; Department of Pathology (KBB, FJH, WPD), University of Mississippi Medical Center, Jackson, Mississippi;  and Department of Surgery (WBV), Uniformed Services University of the Health Sciences, Bethesda, Maryland.

RESUMEN / SUMMARY:  - ABSTRACT:: Adrenal myelolipomas are rare, usually benign unilateral tumors. Their management has controversially been discussed. The authors here present a 53-year-old African American female Jehovah’s witness with postmenopausal uterine bleeding on chronic anticoagulation and episodic right flank pain who was found to have bilateral myelolipomas in addition to primary hyperparathyroidism. In collaboration with gynecology, midline laparotomy was performed to remove uterus  and both ovaries in addition to the right adrenal gland for a 62- x 79-mm myelolipoma. An open biopsy of the left adrenal mass measuring 42 x 43 mm revealed myelolipoma and ruled out malignancy. Pathology confirmed bilateral myelolipomas, endometrial polyps, and leiomyomata uteri. After an uneventful recovery, the patient then underwent a right inferior parathyroidectomy for parathyroid adenoma. This case illustrates the challenges in deciding when to surgically intervene for adrenal myelolipoma and, for the first time, associates  various other endocrinopathies, although no known endocrine neoplasia syndrome variant was present.

 

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[285]

TÍTULO / TITLE:  - Acetabular osteoid osteoma excision by controlled hip dislocation: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Orthop B. 2013 May;22(3):195-9. doi: 10.1097/BPB.0b013e32835f57fc.

            ●● Enlace al texto completo (gratuito o de pago) 1097/BPB.0b013e32835f57fc

AUTORES / AUTHORS:  - de Los Santos O; Filomeno P; Rey R; Cuneo A

INSTITUCIÓN / INSTITUTION:  - aUniversity Clinic of Traumatology and Orthopaedics bDepartment of Clinical Pediatric Orthopedics, Faculty of Medicine, University of the Republic, Montevideo, Uruguay.

RESUMEN / SUMMARY:  - Osteoid osteoma of the acetabulum is rare and its treatment represents a challenge for the orthopedic surgeon. We report a case of a 12-year-old boy with  osteoid osteoma in the acetabulum who was treated with a controlled hip dislocation and a gamma probe guide to facilitate excision. The diagnosis was confirmed by pathology. The patient was asymptomatic immediately after surgery and remained so at long-term follow-up.

 

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[286]

TÍTULO / TITLE:  - Primary and Secondary Leiomyosarcoma of the Oral and Perioral Region-Clinicopathological and Immunohistochemical Analysis of a Rare Entity With a Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Maxillofac Surg. 2013 Feb 20. pii: S0278-2391(12)01729-6. doi: 10.1016/j.joms.2012.12.011.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.joms.2012.12.011

AUTORES / AUTHORS:  - Schutz A; Smeets R; Driemel O; Hakim SG; Kosmehl H; Hanken H; Kolk A

INSTITUCIÓN / INSTITUTION:  - Postgraduate, Department of Oral and Maxillofacial Surgery, University of Regensburg, Regensburg, Germany.

RESUMEN / SUMMARY:  - PURPOSE: Leiomyosarcoma (LMS) rarely occurs in the head and neck region. These tumors present with a wide range of clinical features, so the diagnosis is predicated on conventional microscopic findings coupled with immunohistochemical  analysis. PATIENTS AND METHODS: Clinical and histologic data of 7 patients with LMS of the head and neck were recorded retrospectively. In addition to routine immunohistochemistry, staining for cell cycle regulator proteins p16 and p21 was  performed. RESULTS: Five LMSs (4 intraoral, 1 dermal cheek) occurred primarily in the oral and perioral region. Two LMSs (parietal and sinonasal) were diagnosed as metastases originating from the uterus and pelvis. Treatment of the primary LMSs  consisted of radical tumor resection with clear margins. Distant metastases from  LMSs were irradiated or excised as palliative treatment. Three of 5 patients (60%) with primarily excised LMS developed recurrence after an average of 7 months, with lung metastases occurring after 17 months. In 1 patient, cervical lymph node metastases were detected after 10 months. Of all patients, 5 died after an average survival period of 2.4 years. The mean survival period of the 5  patients with primary LMS of the head and neck was 3.3 years. All tumors were positive for vimentin and alpha-smooth muscle actin, with 57% of tumors showing positive nuclear expression of p16 and 71% of p21. Lack of p16 nuclear expression was associated with a shorter mean survival time (1.3 vs 4.3 yr for p16 positivity). CONCLUSION: Lung and cervical lymph node metastases often occur in LMS of the head and neck. Presurgical staging, including gynecologic examination, whole-body computed tomography, and sometimes positron-emission or computed tomography, to rule out LMS metastasis is mandatory. Surgical resection of the tumor should be given top priority. Lack of p16 reactivity may have a prognostic  value for LMS because it was related to a trend toward poorer survival.

 

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[287]

TÍTULO / TITLE:  - Radical multidisciplinary approach to primary cardiac sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cardiothorac Surg. 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1093/ejcts/ezt029

AUTORES / AUTHORS:  - Shapira OM; Korach A; Izhar U; Koler T; Wald O; Ayman M; Erez E; Blackmon SH; Reardon MJ

INSTITUCIÓN / INSTITUTION:  - Department of Cardiothoracic Surgery, Hebrew University, Hadassah Medical Center, Jerusalem, Israel.

RESUMEN / SUMMARY:  - OBJECTIVES: Primary cardiac sarcomas are extremely rare, but aggressive, tumours. The median survival with conventional treatment is 6-12 months. Recent data suggest that a radical multidisciplinary approach may improve patient outcome. We sought to evaluate our institutional experience with these tumours. METHODS: A multidisciplinary cardiac tumour programme was established 3 years ago based on the experience and support of our collaborating institution. Treatment consisted  of pre- and postoperative chemotherapy, complete (R0) resection of the tumour with structural reconstruction and radiation therapy in selected cases. Left atrial tumours were resected using the cardiac autotransplantation technique. Bovine pericardium was used to reconstruct free-chamber walls or the septum. Valves were replaced by bioprostheses. A variety of autologous, allogeneic and synthetic vascular grafts were used to reconstruct the aorta, pulmonary arteries  (PAs) and coronary arteries. RESULTS: Seven patients (3 males), age 51 +/- 11 years (35-63), underwent eight operations. Tumour sites were PAs in 2 patients, left atrium in 3, right atrium in 2 and both great vessels in 1. Complete resection was achieved in all cases. There was no operative mortality. Two patients required implantation of a permanent pacemaker. Median survival was 24 months. Three patients died of metastatic disease and 1 sudden death 7, 23, 31 and 33 months after diagnosis. Three patients are alive at 2, 8 and 33 months, in functional Class I or II. One patient developed tumour recurrence and 2 have no evidence of disease. CONCLUSIONS: A radical multidisciplinary approach to cardiac sarcomas consisting of multimodality treatment and complex, technically demanding surgery, is safe and markedly improves (doubling) patient survival.

 

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[288]

TÍTULO / TITLE:  - Editorial Comment: Forty years on: pulmonary metastasectomy for sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cardiothorac Surg. 2013 Apr;43(4):799-800. doi: 10.1093/ejcts/ezs448.

            ●● Enlace al texto completo (gratuito o de pago) 1093/ejcts/ezs448

AUTORES / AUTHORS:  - Treasure T; Moller H; Fiorentino F; Utley M

INSTITUCIÓN / INSTITUTION:  - Clinical Operational Research Unit, University College London, London, UK.

 

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[289]

TÍTULO / TITLE:  - Giant liposarcoma elongating mediastinal vessels with intrathoracic inferior vena cava replacement.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cardiothorac Surg. 2013 Mar 18.

            ●● Enlace al texto completo (gratuito o de pago) 1093/ejcts/ezt149

AUTORES / AUTHORS:  - Bille A; Garofalo G; Leo F; Pastorino U

INSTITUCIÓN / INSTITUTION:  - Thoracic Surgery Department, Istituto Nazionale dei Tumori, Milan, Italy.

RESUMEN / SUMMARY:  - Intrathoracic infiltration of the inferior vena cava (IVC) is rare; mobilization  and prosthetic replacement may increase the risk of cardiac arrest and postoperative complications. We report a case of a giant liposarcoma which elongated and grew around the IVC, invading both hemithoraces. The removal of this mass required a bypass between the left femoral and ipsilateral axillary vein to guarantee an adequate venous return. The IVC was replaced by a polytetrafluoroethylene prosthesis. A postoperative paralysis of patient’s lower  limbs occurred. Hypotension or involvement of aberrant medullary artery origin could be responsible for this complication.

 

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[290]

TÍTULO / TITLE:  - Escalating Topotecan in Combination with Treosulfan has Acceptable Toxicity in Advanced Pediatric Sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Hematol Oncol. 2013 Mar 19.

            ●● Enlace al texto completo (gratuito o de pago) 3109/08880018.2013.777948

AUTORES / AUTHORS:  - Bauer F; Filipiak-Pittroff B; Wawer A; von Luettichau I; Burdach S

INSTITUCIÓN / INSTITUTION:  - Department of Pediatrics, Pediatric Oncology Center and Roman-Herzog-Comprehensive Cancer Center (RHCCC), Kinderklinik Munchen Schwabing, Klinik und Poliklinik fur Kinder- und Jugendmedizin, Klinikum Schwabing, StKM GmbH und Klinikum Rechts der Isar der Technischen Universitat Munchen , Munich ,  Germany.

RESUMEN / SUMMARY:  - Patients with advanced pediatric sarcomas have a poor prognosis and novel combination therapies are needed to improve the response rates. Hematological and organ related toxicities have been observed when administering topotecan in combination with, e.g., high dose thiotepa. This study evaluates the toxicity of  escalating doses of topotecan alone or in combination with thiotepa or treosulfan. We compared the toxicity including death of complication (DOC) of topotecan alone or in combination with thiotepa or treosulfan in advanced pediatric sarcomas (n = 12). Ten of 12 patients (0.83) suffered from advanced tumors of the Ewing family (i.e., bone or marrow metastases or relapse <24 month  after diagnosis, including one neuroepithelial tumor of the kidney) and two from  alveolar rhabdomyosarcoma stage IV (0.17). Median age was 15 years (range 5-28).  Ratio of female to male was 1:1. Two patients received topotecan alone (1.25 mg/m2 q 5d and 1.5 mg/m2 q 5d), three patients received four courses of topotecan (2 mg/m2 q d 1-5) in combination with thiotepa (100 mg/m2 q d 1-5), and seven patients received topotecan (2 mg/m2 q d 1-5) in combination with treosulfan (10g/m2 q d 3-5). Overall toxicity was not different between all three groups; mean scores were 1.6, 1.8, and 1.7 according to WHO grading (Scale 0-4). Organ related toxicity ranged between 0 and 4 and was not different as well. DOC was 0/2, 1/3, and 0/7 patients respectively. Escalating therapy with topotecan in combination with treosulfan has acceptable toxicity and warrants further investigation in advanced pediatric sarcomas.

 

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[291]

TÍTULO / TITLE:  - Radiation-induced fibrosarcoma in the neck.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniofac Surg. 2013 Mar;24(2):685-6. doi: 10.1097/SCS.0b013e31827c7f95.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SCS.0b013e31827c7f95

AUTORES / AUTHORS:  - Ibrahimov M; Dag H; Akil F; Mamanov M; Karaman E

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology Head and Neck Surgery Cerrahpasa Medical School Istanbul University Istanbul metinibrahimov@gmail.com.

 

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[292]

TÍTULO / TITLE:  - DNA Repair Systems in Rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Histol Histopathol. 2013 Mar 21.

AUTORES / AUTHORS:  - Tsioli PG; Patsouris ES; Giaginis C; Theocharis SE

INSTITUCIÓN / INSTITUTION:  - First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

RESUMEN / SUMMARY:  - Rhabdomyosarcoma (RMS) represents the most common soft tissue sarcoma in children and adolescent population. There are two major histological subtypes, embryonal (ERMS) and alveolar (ARMS), differing in cytogenetic and morphological features.  RMS pathogenesis remains controversial and several cellular mechanisms and pathways have been implicated. Application of intense chemo- and radio-therapy improves survival rates for RMS patients, but significant efficacy has not been proved as DNA damage induced-resistance frequently occurs. The present review is  aimed at summarizing the current evidence on DNA repair systems, implications in  RMS development, focusing on gene expression alterations and point mutations of genes encoding for DNA repair enzymes. Understanding of DNA repair systems involvement in RMS pathogenesis could diversify RMS patients and provide novel individualized therapeutic targets.

 

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[293]

TÍTULO / TITLE:  - Unusual coexistence of sinonasal myeloid sarcoma and acute fulminant invasive fungal sinusitis: a diagnostic dilemma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Laryngol Otol. 2013 Apr;127(4):415-8. doi: 10.1017/S0022215113000285. Epub 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1017/S0022215113000285

AUTORES / AUTHORS:  - Kuo CL; Yu YB; Li WY; Lee YL

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General  Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan.

RESUMEN / SUMMARY:  - Objective: We report a rare case of concurrent myeloid sarcoma and acute fulminant invasive fungal sinusitis in a patient with relapsed acute myeloid leukaemia. Case report: A 73-year-old man was diagnosed with acute myeloid leukaemia and developed relapse one year later. After two courses of azacytidine, he began suffering from a dull pain in the left temporal and orbital regions. Sinus computed tomography showed a localised lesion in the left ethmoid sinus, which rapidly progressed to an extensive intracranial mass within one month. Surgical debridement was performed, and histopathological analysis revealed the coexistence of myeloid sarcoma and acute fulminant invasive fungal sinusitis. The patient responded well to prompt surgical debridement, antifungal medication and  radiotherapy. Conclusion: Coexistence of sinonasal myeloid sarcoma and acute fulminant invasive fungal sinusitis poses an urgent diagnostic and management challenge to clinicians. Timely recognition of this rare comorbid condition is warranted as application of appropriate treatment can save lives.

 

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[294]

TÍTULO / TITLE:  - Diagnosis and management of Mullerian adenosarcoma of the uterine cervix.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Gynaecol Obstet. 2013 Mar 9. pii: S0020-7292(13)00061-1. doi: 10.1016/j.ijgo.2012.12.015.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijgo.2012.12.015

AUTORES / AUTHORS:  - Chin PS; Chia YN; Lim YK; Yam KL

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Kandang Kerbau Women’s and Children’s Hospital, Singapore. Electronic address: peishi@starhub.net.sg.

RESUMEN / SUMMARY:  - OBJECTIVE: To report on the diagnosis and management of Mullerian adenosarcoma of the uterine cervix at a gynecologic oncology unit in Singapore. METHODS: Nine cases (1992-2008) were identified from the unit registry. All hospital records were retrospectively analyzed. RESULTS: Mean age at diagnosis was 45+/-12years (range, 17-61years). Presenting symptoms were abnormal vaginal bleeding (5 [55.6%] patients), introital mass (3 [33.3%] patients), and foul-smelling vaginal discharge (1 [11.1%] patient). Two (22.2%) patients were asymptomatic, with cervical polyps discovered incidentally on routine gynecologic check-up. All women had benign-looking cervical polyps and underwent polypectomy. Histology showed increased stromal cellularity with periglandular cuffs in all patients, and heterologous differentiation in 1(11.1%) patient. All 9 women had FIGO stage  1B disease. Seven (77.8%) patients underwent radical hysterectomy with bilateral  adnexectomy and pelvic lymphadenectomy. One (11.1%) woman underwent cervical wedge resection and 1 (11.1%) refused definitive surgery. There was no recurrence in the 6 patients for whom complete follow-up data were available. CONCLUSION: Clinical diagnosis of Mullerian adenosarcoma of the uterine cervix may be challenging owing to the benign gross appearance of the cervical polyps. Surgery  provides a good chance of cure with no recurrence.

 

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[295]

TÍTULO / TITLE:  - Radiotherapy for Dermatofibrosarcoma Protuberans.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Clin Oncol. 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1097/COC.0b013e31827dee86

AUTORES / AUTHORS:  - Williams N; Morris CG; Kirwan JM; Dagan R; Mendenhall WM

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL.

RESUMEN / SUMMARY:  - OBJECTIVES:: Dermatofibrosarcoma protuberans (DFSP) is a rare indolent cutaneous  tumor. In this analysis, we assess the effectiveness of postoperative radiotherapy (RT) in treating patients with DFSP. METHODS:: From 1983 to 2011, 14 patients with DFSP were treated with RT at our institution. One patient had gross disease at the time of RT as he did not have a prior resection. The remaining 13  patients were treated with surgery and postoperative RT. Two patients had DFSP with a fibrosarcomatous component (DFSP-FS). External-beam RT was administered in a continuous course to doses ranging from 55.8 to 66.0 Gy. RESULTS:: Follow-up ranged from 1.0 to 23.5 years (median, 10.5). Twelve patients (86%) with DFSP remained disease-free after RT; of those, 11 received postoperative RT and 1 received RT alone. One patient with DFSP-FS died with a local recurrence after surgery, external-beam RT, and a brachytherapy boost. Another patient with DFSP-FS died with diffuse metastatic disease to the lung and chest wall after surgery and RT. There were no serious complications from RT. CONCLUSIONS:: RT may improve local control and reduce the risk of recurrence postoperatively in patients with DFSP.

 

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[296]

TÍTULO / TITLE:  - Gastrointestinal: A cecal lipoma covered by adenomatous epithelium.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastroenterol Hepatol. 2013 Apr;28(4):752. doi: 10.1111/jgh.12129.

            ●● Enlace al texto completo (gratuito o de pago) 1111/jgh.12129

AUTORES / AUTHORS:  - Kim Y; Chang EC; Seo K; Cho YS

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea, College of Medicine, Uijeongbu, South Korea.

 

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[297]

TÍTULO / TITLE:  - Infrarenal transcaval extraction of intracardiac leiomyomatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Vasc Surg. 2013 Feb;27(2):238.e1-4. doi: 10.1016/j.avsg.2012.06.012.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.avsg.2012.06.012

AUTORES / AUTHORS:  - Hinojosa CA; Medina-Franco H; Orozco-Zepeda V; Martinez Mijangos O; Valdes KA; Aragon Han P

INSTITUCIÓN / INSTITUTION:  - Department of Vascular Surgery and Oncological Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico. carlos.a.hinojosa@gmail.com

RESUMEN / SUMMARY:  - Intravascular leiomyomatosis is a rare, histologically benign disease, and can spread through the venous system to the right cavities of the heart. We report the case of a 39-year-old woman who presented with intravenous leiomyomatosis with extension to the right ventricle, causing heart failure. She underwent surgery successfully, undergoing a total resection of this tumor through the infrarenal cava and the hysterectomy in one surgical stage. Surgical technique considerations are discussed and the literature is reviewed.

 

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[298]

TÍTULO / TITLE:  - Cholesterotic Fibrous Histiocytoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Dermatopathol. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 1097/DAD.0b013e3182817be2

AUTORES / AUTHORS:  - Yu M; Kim MS; Han TY; Lee JH; Son SJ

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea.

 

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[299]

TÍTULO / TITLE:  - Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cutan Pathol. 2013 Apr;40(4):379-84. doi: 10.1111/cup.12095.

            ●● Enlace al texto completo (gratuito o de pago) 1111/cup.12095

AUTORES / AUTHORS:  - Al-Zaid T; Wang WL; Lopez-Terrada D; Lev D; Hornick JL; Hafeez Diwan A; Fletcher CD; Lazar AJ

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

RESUMEN / SUMMARY:  - Pleomorphic fibromas represent dome-shaped or polypoid cutaneous lesions characterized by a paucicellular and densely fibrotic background punctuated by scattered atypical to pleomorphic spindle and multinucleated giant cells. Some of these tumors will have incorporated adipose tissue, although these adipocytic areas lack distinct cytologic atypia and may represent entrapped normal periadnexal or subcutaneous adipose tissue. Nonetheless, owing to the similarity  of some of the morphologic features of pleomorphic fibroma with cutaneous atypical lipomatous tumor, diagnostic confusion can ensue. The potential diagnostic challenges are further highlighted by a recent report of a lesion with histopathologic features of both. In response, we studied the presence of 12q15/  MDM2 amplification by fluorescence in situ hybridization and MDM2 expression by immunohistochemistry in a series of 15 pleomorphic fibromas to investigate whether these two entities share a common pathogenic origin. One case of cutaneous atypical lipomatous tumor was used as positive control for 12q15 amplification. All 15 cases were negative for MDM2 by immunohistochemistry with no demonstrable 12q15/MDM2 amplification by fluorescence in situ hybridization. Therefore, these two entities are best regarded as pathogenetically distinct. MDM2 immunohistochemistry or fluorescence in situ hybridization studies can be used to differentiate between the two if needed.

 

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[300]

TÍTULO / TITLE:  - Enhancement of osteosarcoma cell sensitivity to cisplatin using paclitaxel in the presence of hyperthermia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Hyperthermia. 2013 Mar 25.

            ●● Enlace al texto completo (gratuito o de pago) 3109/02656736.2013.775511

AUTORES / AUTHORS:  - Huang T; Gong W; Li X; Zou C; Jiang G; Li X; Feng D

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, First Affiliated Hospital of China Medical University , Shenyang, Liaoning , China and.

RESUMEN / SUMMARY:  - Abstract Purpose: This paper aimed to evaluate the effects of a combination of paclitaxel and cisplatin on osteosarcoma (OS) cell lines in the presence of hyperthermia and to investigate the related mechanism. Materials and methods: Two types of OS cell lines (OS732 and MG63) were treated with paclitaxel and cisplatin in the presence of hyperthermia. The survival rate was measured by MTT  assay, and the clonogenic rate was measured by a clonogenic assay. The cellular changes were observed with an inverted phase contrast microscope and a fluorescence microscope. The apoptotic effect was analysed with flow cytometry (FCM). Fas expression by the OS cell lines was measured by western blot. Fas expression in OS tissue was measured by immunohistochemistry. Results: Our study  indicated that 1 h after the application of a combination of 10 mug/mL paclitaxel and 5 mug/mL cisplatin to OS cells at 43 degrees C, the survival rate of the OS cells was 11.96%, which was significantly lower than when either 10 mug/mL paclitaxel (45.02%) or 5 mug/mL cisplatin (48.69%) was applied alone (p < 0.01).  Additionally, the clonogenic assay demonstrated that the clonogenic survival rate in the OS cells of the combination group was lower than that in the individual groups. Moreover, the cellular changes and apoptosis rates indicated that apoptosis in the combined application group was much greater than when either drug was applied individually. Fas expression by OS cell lines was increased by the combination of paclitaxel and cisplatin under hyperthermic conditions. More importantly, our study revealed low Fas expression in OS, which better explained  the up-regulation of Fas achieved by the combination of paclitaxel and cisplatin  in the presence of hyperthermia. Conclusions: The combination of paclitaxel and cisplatin increases the effects of thermochemotherapy on OS cell lines, primarily through the induction of apoptosis by the up-regulation of Fas expression.

 

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[301]

TÍTULO / TITLE:  - Planned preservation surgery for soft tissue sarcomas adjacent to critical structures.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Orthop Trauma Surg. 2013 Apr;133(4):481-6. doi: 10.1007/s00402-013-1690-0. Epub 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00402-013-1690-0

AUTORES / AUTHORS:  - Tsukushi S; Nishida Y; Urakawa H; Arai E; Kozawa E; Ishiguro N

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan, s-tsuku@med.nagoya-u.ac.jp.

RESUMEN / SUMMARY:  - BACKGROUND: Whether to preserve or sacrifice critical structures (bone, major vessels and major nerves) adjacent to soft tissue sarcomas is still controversial. Referring to characteristic imaging and intraoperative findings, we perform planned preservation surgery for these critical structures. The aim of this study was to investigate the clinical outcome of soft tissue sarcomas adjacent to critical structures and to validate this procedure. METHODS: Of 202 cases of soft tissue sarcomas surgically treated at our department of orthopedic  surgery from 2004 to 2010, 57 cases (28 %) whose tumors were adjacent to the critical structures were studied. There were 36 men and 21 women. In 32 cases critical structures were preserved, and in 25 resected together with the tumor. The oncological outcome and histological surgical margin were analyzed. RESULTS:  The overall survival and local recurrence-free survival rates at 5 years were 75.9 and 83.2 %. In 26 of the 32 (81 %) preserved cases histologically the surgical margin was negative, and in 17 (53 %) radiotherapy could be avoided. Neither overall survival (p = 0.9669) nor local recurrence-free survival (p = 0.7819) differed significantly between two groups. CONCLUSIONS: When soft tissue  sarcomas are located adjacent to bone or major vessels, by meticulously detaching the periosteum or neurovascular sheath referring to characteristic imaging and intraoperative findings, a histologically negative surgical margin can be achieved in the majority, allowing avoidance of postoperative radiotherapy. Planned preservation surgery provided no significant adverse effect on survival or local recurrence rates, validating this procedure.

 

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[302]

TÍTULO / TITLE:  - Multiple Intramural Right Atrial Myxomas Encountered Incidentally during Coronary Artery Bypass Surgery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tex Heart Inst J. 2013;40(1):102-3.

AUTORES / AUTHORS:  - Mehrotra D; Riordon J

INSTITUCIÓN / INSTITUTION:  - Department of Cardiothoracic Surgery, Wellington Hospital, Wellington 6021, New Zealand.

 

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[303]

TÍTULO / TITLE:  - Novel p53 splicing site mutation in Li-Fraumeni-like syndrome with osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Int. 2013 Feb;55(1):107-11. doi: 10.1111/j.1442-200X.2012.03641.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1442-200X.2012.03641.x

AUTORES / AUTHORS:  - Sakurai N; Iwamoto S; Miura Y; Nakamura T; Matsumine A; Nishioka J; Nakatani K; Komada Y

INSTITUCIÓN / INSTITUTION:  - Departments of Pediatrics and Developmental Science Orthopaedic Surgery, Mie University Graduate School of Medicine Division of Personalized Medicine, Mie University Hospital, Tsu, Mie, Japan.

RESUMEN / SUMMARY:  - We describe a 15-year-old girl with a novel germline p53 splice site mutation who developed an osteosarcoma. She received several cycles of chemotherapy with complete resection of the primary tumor without amputation, and has maintained remission for 18 months. Li-Fraumeni-like syndrome was suspected based on familial history. Sequence analysis revealed the presence of a novel germline p53 gene mutation resulting in a G to A transition at position +1 at the donor splice site of intron 6, creating a 6 amino acid insertion. This case provides interesting insight into the phenotype-genotype correlation in LFL syndrome with  a TP53 splicing mutation.

 

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[304]

TÍTULO / TITLE:  - Anti-N-methyl-d-aspartate encephalitis with ovarian cystadenofibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Neurol. 2013 Mar;48(3):232-5. doi: 10.1016/j.pediatrneurol.2012.10.013.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.pediatrneurol.2012.10.013

AUTORES / AUTHORS:  - Sanmaneechai O; Song JL; Nevadunsky N; Moshe SL; Overby PJ

INSTITUCIÓN / INSTITUTION:  - Saul R. Korey Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA. oranee141@gmail.com

RESUMEN / SUMMARY:  - We report the case of an adolescent girl with anti-N-methyl-D-aspartate-receptor  (NMDAR) encephalitis who presented with focal seizures and hemichorea, followed by agitation, speech disturbance, mutism, and autonomic dysfunction. The institution of immunotherapy and removal of an ovarian cystadenofibroma led to full resolution of her symptoms with disappearance of serum NMDAR antibodies. This is the first report linking ovarian cystadenofibroma to anti-NMDAR encephalitis.

 

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[305]

TÍTULO / TITLE:  - Evaluation of novel serum biomarkers and the proteomic differences of endometriosis and adenomyosis using MALDI-TOF-MS.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Gynecol Obstet. 2013 Feb 1.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00404-012-2700-0

AUTORES / AUTHORS:  - Long X; Jiang P; Zhou L; Zhang W

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, XuanWu Hospital, Capital Medical University, 45# Changchun Street, XuanWu District, Beijing, China.

RESUMEN / SUMMARY:  - BACKGROUND: Both endometriosis and adenomyosis are common benign gynecological diseases. This study aimed to find the novel noninvasive, biochemical diagnostic  markers for detection of endometriosis and adenomyosis, and evaluate the correlation of these two diseases at the protein level. METHODS: Serum samples from patients with endometriosis or adenomyosis were compared with control groups to detect specific serum biomarkers and to explore the different protein fingerprint of endometriosis and adenomyosis using MALDI-TOF-MS. RESULT(S): There were 13 protein peaks abnormally expressed in endometriosis as well as twelve in  adenomyosis compared with control groups (P < 0.05). And five-peak mass was found downregulated significantly both in the women with endometriosis and adenomyosis. The common diagnostic model of endometriosis and adenomyosis we set up had a lower sensitivity and specificity than the separate diagnostic model of these two diseases. CONCLUSION(S): MALDI-TOF-MS technology plays an important role in screening the diagnostic biomarkers of endometriosis and adenomyosis. And our study found the correlation between endometriosis and adenomyosis in protein fingerprint and it is hard to separate the endometriosis from adenomyosis with the serum biomarkers.

 

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[306]

TÍTULO / TITLE:  - Mixed epithelial and stromal tumor-cytologic findings of an unusual renal cyst.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Cytopathol. 2013 Feb 27. doi: 10.1002/dc.22964.

            ●● Enlace al texto completo (gratuito o de pago) 1002/dc.22964

AUTORES / AUTHORS:  - Defanti LE; Nodit L

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee.

 

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[307]

TÍTULO / TITLE:  - An accessory limb with lipomyelomeningocele in a male.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Surg Int. 2013 Feb 8.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00383-013-3269-9

AUTORES / AUTHORS:  - Murphy RF; Cohen BH; Muhlbauer MS; Eubanks JW 3rd; Sawyer JR; Moisan A; Kelly DM

INSTITUCIÓN / INSTITUTION:  - Le Bonheur Children’s Hospital, University of Tennessee-Campbell Clinic Department of Orthopaedic Surgery, 1211 Union Avenue, Suite 510, Memphis, TN, 38104, USA.

RESUMEN / SUMMARY:  - At 7 months, an infant born with a third limb attached to a lumbosacral mass with an associated lipomyelomeningocele underwent removal of the limb and spinal cord  detethering. Depending on the complexity of the pathology and proximity of the limb to viscera, consultation with neurosurgical and surgical colleagues is recommended.

 

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[308]

TÍTULO / TITLE:  - Aneurysmal bone cyst within fibrous dysplasia of the anterior skull base: continued intracranial extension after endoscopic resections requiring craniofacial approach with free tissue transfer reconstruction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Childs Nerv Syst. 2013 Feb 26.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00381-013-2034-7

AUTORES / AUTHORS:  - Manjila S; Zender CA; Weaver J; Rodgers M; Cohen AR

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Neurosurgery & Minimally Invasive Neurosurgical Laboratory, University Hospitals Case Medical Center, Cleveland, OH, USA.

 

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[309]

TÍTULO / TITLE:  - The contribution of electron microscopy to the characterization of soft tissue fibrosarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ultrastruct Pathol. 2013 Feb;37(1):9-14. doi: 10.3109/01913123.2012.670017.

            ●● Enlace al texto completo (gratuito o de pago) 3109/01913123.2012.670017

AUTORES / AUTHORS:  - Franchi A; Santucci M

INSTITUCIÓN / INSTITUTION:  - Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy. Franchi@unifi.it

RESUMEN / SUMMARY:  - In recent years, with the application of immunohistochemical and cytogenetic methods, numerous lesions formerly diagnosed as fibrosarcoma were reclassified as other malignant soft tissue tumors, and therefore conventional fibrosarcoma has largely become a diagnosis of exclusion. On the other hand, several new entities  belonging to the group of fibrosarcomas have been characterized, including low-grade fibromyxoid sarcoma / hyalinizing spindle cell tumor with giant rosettes, sclerosing epithelioid fibrosarcoma, acral myxoinflammatory fibroblastic sarcoma, and the epithelioid variant of myxofibrosarcoma. Electron microscopy has contributed to the identification of the fibroblastic phenotype in these fibrosarcoma variants and still retains a central role in the differential  diagnosis of these soft tissue sarcomas, thus helping to render specific diagnoses and to broaden the spectrum of fibrosarcoma variants.

 

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[310]

TÍTULO / TITLE:  - Small intestinal lipoma causing obscure gastrointestinal bleeding.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Intern Med. 2013;52(5):633-4. Epub 2013 Mar 1.

AUTORES / AUTHORS:  - Sawada T; Yoshida M; Adachi Y; Endo T

INSTITUCIÓN / INSTITUTION:  - Division of Gastroenterology, Department of Internal Medicine, Sapporo Shirakaba-dai Hospital, Japan.

 

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[311]

TÍTULO / TITLE:  - A novel combined surgical approach to head and neck dermatofibrosarcoma protuberans.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniomaxillofac Surg. 2013 Feb 25. pii: S1010-5182(13)00010-3. doi: 10.1016/j.jcms.2013.01.009.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcms.2013.01.009

AUTORES / AUTHORS:  - Agostini T; Dini M; Quattrini Li A; Grassetti L; Mori A; Spinelli G; Russo GL; Lazzeri D

INSTITUCIÓN / INSTITUTION:  - Department of Plastic and Reconstructive, CTO-AOUC, University of Florence, Largo Palagi 1, 50134, Italy; Department of Maxillo-Facial Surgery, CTO-AOUC, University of Florence, Italy. Electronic address: tommasoagostini@ymail.com.

RESUMEN / SUMMARY:  - INTRODUCTION: The surgical management of dermatofibrosarcoma protuberans has historically been a challenge, particularly in the head and neck and other aesthetic areas. The current priority is to achieve local oncologic control and a good reconstructive outcome. Here, we present our experience using a novel combined approach with a dermal regenerative template, sub-atmospheric pressure and skin graft. MATERIALS AND METHODS: Five patients presenting at the Department of Plastic and Reconstructive Surgery of the University of Florence between January 2010 and October 2011 were included in the study following Institutional  Review Board approval. All patients underwent a wide local excision of dermatofibrosarcoma protuberans affecting the head and neck. RESULTS: The combined approach using the negative-pressure device, a dermal regenerative template and skin grafting proved effective in the management of this type of sarcoma with a good aesthetic and functional outcome, particularly on the neck or the supraclavicular region. CONCLUSION: Although the present multi-step technique requires patient compliance, it results in good local oncologic control of the resection margins. It is possible to perform a wider excision in the event of positive margins without interfering with the last reconstructive outcome.

 

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[312]

TÍTULO / TITLE:  - Feasibility of a new two-step procedure for office hysteroscopic resection of submucous myomas: results of a pilot study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Obstet Gynecol Reprod Biol. 2013 Jan 30. pii: S0301-2115(13)00027-4. doi: 10.1016/j.ejogrb.2013.01.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejogrb.2013.01.002

AUTORES / AUTHORS:  - Haimovich S; Mancebo G; Alameda F; Agramunt S; Sole-Sedeno JM; Hernandez JL; Carreras R

INSTITUCIÓN / INSTITUTION:  - Service of Obstetrics and Gynecology, Hospital Universitari Parc de Salut Mar, Auniversitat Autonoma de Barcelona, Barcelona, España. Electronic address: sergio@haimovich.net.

RESUMEN / SUMMARY:  - OBJECTIVE: To assess the feasibility of a new two-step technique for office hysteroscopic resection of submucous myomas. STUDY DESIGN: Between January 2010 and December 2011, all consecutive patients of reproductive age with symptomatic  lesions sonographically diagnosed as single mainly intracavitary (G1 or G2) myoma </=4.0cm were eligible to participate in a prospective study. They underwent a two-step hysteroscopic procedure, which included preparation of partially intramural myomas with incision of the endometrial mucosa and the pseudocapsule covering the myoma in the first step, and excision of the myoma by means of diode laser four weeks later. All procedures were performed on an outpatient basis and  without anesthesia. RESULTS: A total of 43 women (mean age 36.7 years) were included. The two-step myomectomy technique was successfully performed in 34 (79.1%) patients. All myomas </=18mm were successfully enucleated as compared with 85% of 19-30mm, and 0% of >/=30mm (P<0.001). Also, myomas located in the anterior/posterior walls and those located in the fundus/lateral walls were enucleated in 87.9% and 50% of cases, respectively (P=0.020). Success of surgery  was not influenced by the initial type of myoma. CONCLUSION: The new two-step hysteroscopic myomectomy carried out as an outpatient procedure and without anesthesia is feasible for the excision of symptomatic submucous fibroids.

 

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[313]

TÍTULO / TITLE:  - Fibrolipoma of the Orbit.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ophthal Plast Reconstr Surg. 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IOP.0b013e318272f32b

AUTORES / AUTHORS:  - Ali SF; Farber M; Meyer DR

INSTITUCIÓN / INSTITUTION:  - Department of Ophthalmology, Albany Medical College, Albany, New York, U.S.A.

RESUMEN / SUMMARY:  - Herein we present a retrospective case report of a very rare fibrolipoma originating in the orbit. Lipomas and related variants presenting in the orbit are very rare. Only 2 documented orbital fibrolipomas were noted in our review of literature. A 26-year-old woman presented with a growing mass below the left eyebrow 4 years after suffering facial trauma after being kicked in the face by a horse. CT demonstrated a hypodense nodule adherent to the orbital portion of the  left frontal bone that was not encapsulated. An elective left anterior orbitotomy with excisional biopsy was performed, and fibrolipoma was confirmed on histopathologic examination. There was no evidence of tumor after 2-year follow up. The presence of a fibrolipoma in the periosteum of the orbital rim is very rare and might be a result of inflammatory transformation following facial trauma.

 

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[314]

TÍTULO / TITLE:  - Collagenous Fibroma (Desmoplastic Fibroblastoma) of the Orbital Rim.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ophthal Plast Reconstr Surg. 2013 Feb 26.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IOP.0b013e31827deffe

AUTORES / AUTHORS:  - Stacy RC; Jakobiec FA; Fay A

INSTITUCIÓN / INSTITUTION:  - *David G. Cogan Ophthalmic Pathology Laboratory, and daggerOculoplastics Division, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.

RESUMEN / SUMMARY:  - A 40-year-old woman with left periorbital swelling for 1 month presented without  diplopia or change in vision. Imaging studies revealed a 1-cm mass at the frontozygomatic junction at the orbital rim with slight bony erosion and spiculation. The lesion was applied to the periosteum and was excised along with  a portion of the bony orbital rim. Histopathology revealed elongated and stellate fibroblasts within a dense collagenous matrix. Vimentin and Masson trichrome staining was consistent with a collagenous fibroma, a rare tumor that has, only once before, been reported in the orbit in the lacrimal fossa region. The current collagenous fibroma arose from the periosteum to grow exophytically, causing minimal bone changes. A literature review shows that this condition predominantly affects middle-aged and older adults rather than children.

 

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[315]

TÍTULO / TITLE:  - Validity and reproducibility of Ki-67 assessment in gastrointestinal stromal tumors and leiomyosarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Int. 2013 Feb;63(2):102-7. doi: 10.1111/pin.12038. Epub 2013 Feb 22.

            ●● Enlace al texto completo (gratuito o de pago) 1111/pin.12038

AUTORES / AUTHORS:  - Ogino J; Asanuma H; Hatanaka Y; Matsuno Y; Gotoda H; Muraoka S; Tsuji T; Fukazawa Y; Yamashiro K; Kondo N; Iwaki H; Miyokawa N; Hasegawa T

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Pathology, Sapporo Medical University School of Medicine,  Sapporo, Japan.

RESUMEN / SUMMARY:  - With the aim of standardizing Ki-67 immunohistochemistry, we assessed interobserver and interlaboratory variability of the Ki-67 labeling index and Ki-67 score among eight general pathologists for 24 gastrointestinal stromal tumors (GISTs) and 12 leiomyosarcomas, which were predominantly of the gastrointestinal (GI) tract, mesentery and retroperitoneum, based on a review of  a tissue microarrays subjected to immunohistochemistry with antibodies for Ki-67. For Ki-67 immunostaining of mesenchymal tumors of the GI tract, including GISTs,  differences were seen in the scores given by regional hospitals. Conversely, for  two categories of the Ki-67 labeling index, namely <10% and >/=10%, concordance of the Ki-67 score between microscopic observation and image analysis, and between the observers, was good, but it was not good for the other four categories of the index for <5%, 5-9%, 10-29%, and >/=30%. The concordance of the Ki-67 scores between the observers in two categories was higher using the Ki-67 pre-stained tissue microarrays (TMAs) within each participating institute than that using the Ki-67 stained TMAs between the participating institutes. The reproducibility of a 10% cut-off value for the Ki-67 labeling index to predict the prognosis of GISTs was relatively high, but there is an urgent need to standardize the staining technique.

 

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[316]

TÍTULO / TITLE:  - Ovarian osteoma mimicking a teratoma on ultrasound.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Gynaecol Obstet. 2013 Mar 14. pii: S0020-7292(13)00097-0. doi: 10.1016/j.ijgo.2013.01.015.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijgo.2013.01.015

AUTORES / AUTHORS:  - Yung SS; Cheung VY; Chan GS

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: yungsofie@gmail.com.

 

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[317]

TÍTULO / TITLE:  - Ewing’s sarcoma of the patella.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Skeletal Radiol. 2013 May;42(5):729-33. doi: 10.1007/s00256-013-1580-0. Epub 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00256-013-1580-0

AUTORES / AUTHORS:  - Gorelik N; Dickson BC; Wunder JS; Bleakney R

INSTITUCIÓN / INSTITUTION:  - Faculty of Medicine, McGill University, Montreal, QC, Canada, natalia.gorelik@mail.mcgill.ca.

RESUMEN / SUMMARY:  - Ewing’s sarcoma is a relatively rare malignancy, occurring mainly between 4 and 25 years of age. It usually arises from the pelvis, followed by the femur, tibia, and remainder of both the long bones of the extremities and flat bones of the axial skeleton. To the best of our knowledge, Ewing’s sarcoma of the patella has  never been reported previously. Patellar tumors occur infrequently and represent  an uncommon etiology of anterior knee pain. We describe the rare case of a 41-year-old man who presented with a 3-4 month history of escalating right anterior knee pain and swelling. Imaging demonstrated an aggressive patellar tumor with an adjacent soft tissue mass. The diagnosis of Ewing’s sarcoma was confirmed by pathology. Physicians should be aware of atypical locations for Ewing’s sarcoma and, conversely, of rare tumors arising in the patella and accounting for anterior knee pain. Early recognition of such malignancies allows  prompt initiation of treatment, hence improving prognosis.

 

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[318]

TÍTULO / TITLE:  - Intra-articular synovial sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Skeletal Radiol. 2013 Mar 1.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00256-013-1589-4

AUTORES / AUTHORS:  - Friedman MV; Kyriakos M; Matava MJ; McDonald DJ; Jennings JW; Wessell DE

INSTITUCIÓN / INSTITUTION:  - Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO, 63110, USA, friedmanm@mir.wustl.edu.

RESUMEN / SUMMARY:  - A case of right knee intra-articular synovial sarcoma in a 26-year-old man is reported. The patient had experienced 12 to 18 months of chronic posterior right  knee pain with flexion contracture of the leg. Magnetic resonance imaging (MRI) examination demonstrated nonspecific characteristics of a well-circumscribed, homogeneous mass within the posterior lateral compartment of the knee joint. The  mass was isointense and hyperintense to muscle on T1- and T2-weighted sequences respectively, and initially clinically diagnosed as a localized tenosynovial giant cell tumor. However, histological examination showed the lesion to be a synovial sarcoma arising from the synovium of the knee joint. Synovial sarcoma may have a nonspecific MR appearance, especially when less than 5 cm in size, often simulating a less aggressive process. Primary intra-articular origin may predispose to earlier presentation, and therefore, radiological evaluation of smaller masses. Nonspecific MR characteristics of small, intra-articular masses provide a diagnostic dilemma. Synovial sarcoma should be considered in the differential diagnosis when distinguishing MR characteristics of other common joint-centered entities are not present.

 

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[319]

TÍTULO / TITLE:  - Heart extension of an intravenous leiomyomatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Mar;37(2):369-73. doi: 10.1016/j.clinimag.2012.04.022.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.04.022

AUTORES / AUTHORS:  - Matos AP; Ramalho M; Palas J; Heredia V

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Hospital Garcia de Orta, Almada, Setubal 2801-951, Portugal.

RESUMEN / SUMMARY:  - Intravenous leiomyomatosis is a rare growth pattern of benign uterine leiomyomas. Approximately 300 cases of intravenous leiomyomatosis have been reported in the English literature; however, there have only been a few in radiology journals. Even more rare is its extension through the inferior vena cava and heart chambers. Radiologic diagnosis can be challenging, as it is often difficult to differentiate it from other entities. We present a case of a 45-year-old woman with a cardiac extension of an intravenous leiomyomatosis and discuss the cross-sectional imaging appearance of this entity as well as the differential diagnosis.

 

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[320]

TÍTULO / TITLE:  - Chondroma of the nasal tip.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniofac Surg. 2013 Mar;24(2):e153-5. doi: 10.1097/SCS.0b013e31827c8319.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SCS.0b013e31827c8319

AUTORES / AUTHORS:  - Ozturan O; Degirmenci N; Yenigun A

INSTITUCIÓN / INSTITUTION:  - From the Medical Faculty, Department of Otorhinolaryngology and Head and Neck Surgery, Bezmialem Vakif University, Istanbul, Turkey.

RESUMEN / SUMMARY:  - Chondromas are benign lesions composed of mature hyaline cartilage. A nasal chondroma is an infrequent entity and it arises rarely from the nasal septum. Most of the nasal chondroma cases in the medical literature have originated from  the posterior part of the septum. This article presents a rare case of nasal chondroma. A 47-year-old female patient consulted to our clinic complaining of a  lump of medium hardness at the tip of her nose. Surgery revealed a nasal chondroma, localized at the domal alar cartilage. The case was presented in detail, and the diagnosis, treatment, and follow-up of nasal chondromas were discussed in light of relevant literature.

 

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[321]

TÍTULO / TITLE:  - Radiologic evaluation of right ventricular outflow tract myxomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tex Heart Inst J. 2013;40(1):68-70.

AUTORES / AUTHORS:  - Lacey BW; Lin A

INSTITUCIÓN / INSTITUTION:  - Departments of Internal Medicine (Dr. Lacey) and Cardiology (Dr. Lin), Naval Medical Center, San Diego, California 92134.

RESUMEN / SUMMARY:  - A 22-year-old man was referred for palpitations. On transthoracic echocardiography, he was found to have a right ventricular outflow tract mass. Further cardiac imaging was conducted by means of transesophageal echocardiography, computed tomography, and cardiac magnetic resonance. Complete surgical resection of the tumor was achieved, and pathologic examination revealed the lesion to be a myxoma. Cardiac tumors located in the right ventricular outflow tract are rare and can present unusual diagnostic and therapeutic challenges. Cardiac computed tomography and magnetic resonance are becoming more  widely available and can be useful adjuncts in the management of such tumors.

 

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[322]

TÍTULO / TITLE:  - Intramasseteric solitary fibrous tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniofac Surg. 2013 Mar;24(2):e157-9. doi: 10.1097/SCS.0b013e31827c8336.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SCS.0b013e31827c8336

AUTORES / AUTHORS:  - Dogan E; Erdag TK; Ikiz AO; Guneri A; Sarioglu S

INSTITUCIÓN / INSTITUTION:  - From the *Department of Otorhinolaryngology Head and Neck Surgery, and daggerDepartment of Pathology, Dokuz Eylul University School of Medicine, Izmir,  Turkey.

RESUMEN / SUMMARY:  - Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm that usually arises  from the pleura. SFTs occurring within the head and neck region are uncommon. Recently, it has been described in various head and neck sites such as oral cavity, nasal cavity, paranasal sinuses, salivary glands, thyroid, buccal space,  and larynx. Here, we report a case of SFT originating in the masseter muscle of a 27-year-old woman. To our knowledge, this is the first description of a SFT of the head and neck region, arising within the masseter muscle. We present the clinical history, radiologic and histopathologic findings as well as immunoreactivity of this tumor.

 

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[323]

TÍTULO / TITLE:  - Isolated intraosseous lipoma of the ethmoid sinus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniomaxillofac Surg. 2013 Feb 28. pii: S1010-5182(13)00011-5. doi: 10.1016/j.jcms.2013.01.010.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcms.2013.01.010

AUTORES / AUTHORS:  - Elsurer C; Hanci D; Cakir A; Dal T

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology, Acibadem Healthcare Group, Fulya Hospital, Istanbul, Turkey. Electronic address: cagdaselsurer@yahoo.com.

RESUMEN / SUMMARY:  - Intraosseous lipoma is an extremely rare variant of lipoma. It is most commonly found in the appendicular skeleton and only very rarely in skull base. We present a 38-year-old male patient who was admitted to our clinic with the symptoms of nasal obstruction and headache. Computed tomography (CT) showed a hyperdense area with surrounding calcification was demonstrated in the anteromedial part of ethmoid sinus. Endoscopic left anterior ethmoidectomy was performed and the mass  was totally excised. Histopathological examination was consistent with Milgram’s  stage 1 intraosseous lipoma. To our knowledge, this is the first reported case of isolated intraosseous lipoma of the ethmoid sinuses in the literature.

 

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[324]

TÍTULO / TITLE:  - Juvenile hyalin fibromatosis as a cause of external nasal obstruction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniofac Surg. 2013 Mar;24(2):686-7. doi: 10.1097/SCS.0b013e31827c7fad.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SCS.0b013e31827c7fad

AUTORES / AUTHORS:  - Aytekin AH; Coban YK

INSTITUCIÓN / INSTITUTION:  - Inuno University Malatya, Turkey ykenanc@yahoo.com.

 

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[325]

TÍTULO / TITLE:  - Intra-articular osteoid osteoma of the first metatarsal.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Foot Ankle Int. 2013 Mar;34(3):448-54. doi: 10.1177/1071100712465847. Epub 2013 Jan 11.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1071100712465847

AUTORES / AUTHORS:  - Asuncion J; Torrent J; Gonzalez C; Poggio D

INSTITUCIÓN / INSTITUTION:  - Foot and Ankle Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, España.

 

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[326]

TÍTULO / TITLE:  - Primary intradural extraosseous Ewing’s sarcoma of the lumbar spine presenting with acute bleeding.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Neurosurg. 2013 Mar 8.

            ●● Enlace al texto completo (gratuito o de pago) 3109/02688697.2013.772102

AUTORES / AUTHORS:  - Khalatbari MR; Jalaeikhoo H; Moharamzad Y

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Arad Hospital , Tehran , Iran.

RESUMEN / SUMMARY:  - We report the case of a 28-year-old female with primary extraosseous Ewing’s sarcoma who presented initially with a low back pain and a right S1 radicular pain. Before scheduled surgical removal, she suddenly developed an unusual complication of an acute hemorrhage and an acute cauda equina syndrome. Emergency surgery was done which demonstrated an acute bleeding. Treatment was followed by  the chemotherapy and the adjuvant radiotherapy. Follow-up has been done for 6 years after presentation.

 

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[327]

TÍTULO / TITLE:  - Neurofibroma of the bile duct: a rare cause of obstructive jaundice.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann R Coll Surg Engl. 2013 Mar;95(2):38-40. doi: 10.1308/003588413X13511609955931.

            ●● Enlace al texto completo (gratuito o de pago) 1308/003588413X13511609955931

AUTORES / AUTHORS:  - De Rosa A; Gomez D; Zaitoun AM; Cameron IC

INSTITUCIÓN / INSTITUTION:  - Nottingham University Hospitals NHS Trust, UK.

RESUMEN / SUMMARY:  - Neurofibromas of the common bile duct are extremely rare. The lack of specific clinical or radiological features makes preoperative diagnosis in the absence of  histology difficult. We report the case of a female patient who presented with obstructive jaundice and evidence of a common bile duct stricture on imaging. She underwent an exploratory laparotomy, and intraoperative frozen section confirmed  clear margins and a benign lesion. Excision of the extrahepatic bile duct and A Rouxen-Y hepaticojejunostomy was performed. We discuss the clinical features and  management of neurofibromas of the bile duct in light of the literature.

 

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[328]

TÍTULO / TITLE:  - Multiplanar osteotomies guided by navigation in chondrosarcoma of the knee.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orthopedics. 2013 Mar 1;36(3):e325-30. doi: 10.3928/01477447-20130222-21.

            ●● Enlace al texto completo (gratuito o de pago) 3928/01477447-20130222-21

AUTORES / AUTHORS:  - Aponte-Tinao LA; Ritacco LE; Ayerza MA; Muscolo DL; Farfalli GL

RESUMEN / SUMMARY:  - Surgical resection with adequate margins is the treatment of choice in chondrosarcoma. However, well-circumscribed lesions can be completely resected by performing multi-planar osteotomies guided by computer-assisted navigation. This  type of resection had been recently described in select patients with sarcomas; however, these osteotomies are technically demanding to plan and perform intraoperatively. The use of navigation to assist in surgery is becoming more frequently described in orthopedic oncology.The authors performed multiplanar osteotomy resections guided by navigation and reconstruction with intercalary allografts in 5 patients with chondrosarcoma around the knee. All the patients were women, with a mean age of 56 years. Four tumors were located in the distal femur and 1 in the proximal tibia. The 5 surgical anatomic specimens were 3-dimensionally reconstructed postoperatively and superimposed on a preoperative  plan to check whether the resected specimen was consistent with the preoperative  planned resection. At final follow-up, no patient experienced a local recurrence  or metastasis. Four osteotomies each were performed in 3 patients, and 3 osteotomies each were performed in 2 patients, so 18 planes were evaluated. Mean  difference in distance between preoperative vs final planes was 2.43 mm. Average  functional score was 29 points. All patients resumed activities of daily living without restriction. This study’s results show that navigation with adequate preoperative planning allows surgeons to intraoperatively reproduce the planned resection with accuracy in complex multiplanary resections.

 

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[329]

TÍTULO / TITLE:  - Predictors of local recurrence in high-grade soft tissue sarcomas: hydrogen peroxide as a local adjuvant.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orthopedics. 2013 Feb;36(2):e207-15. doi: 10.3928/01477447-20130122-24.

            ●● Enlace al texto completo (gratuito o de pago) 3928/01477447-20130122-24

AUTORES / AUTHORS:  - Wooldridge AN; Kolovich GP; Crist MK; Mayerson JL; Scharschmidt TJ

INSTITUCIÓN / INSTITUTION:  - Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.

RESUMEN / SUMMARY:  - Soft tissue sarcomas have a mortality rate of 40% to 60%, with local recurrence being a poor prognostic factor for overall survival. Three-percent nondiluted hydrogen peroxide is hypothesized to be an effective local adjuvant. The purpose  of this study was to identify risk factors for local recurrence in high-grade soft tissue sarcomas and to determine whether using hydrogen peroxide as a local  adjuvant reduced the risks of local recurrence and surgical-site infection. Retrospective data were collected for 106 patients surgically treated for high-grade soft tissue sarcomas between 2002 and 2010. The primary endpoint was local recurrence. Eighteen (16.98%) cases of local recurrence occurred. Predictors of local recurrence were margin status, estimated blood loss, and histology (ie, malignant peripheral nerve sheath tumor), with hazard ratios of 4.44 (95% confidence interval [CI], 1.32-14.95), 1.19 (95% CI, 1.06-1.35), and 9.21 (95% CI, 2.11-40.16), respectively. Hydrogen peroxide yielded a statistically insignificant improvement in local recurrence, with a hazard ratio  of 0.81 (95% CI, 0.27-2.48) and a reduced risk of surgical site infection, with a hazard ratio of 0.52 (95% CI, 0.15-1.81). Margin status, increased blood loss, and histologic subtype are associated with increased local recurrence risk. Using hydrogen peroxide improved local control and infection rates, but the difference  was not statistically significant.

 

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[330]

TÍTULO / TITLE:  - Osteosarcoma and chondrosarcoma of the shoulder: site-specific comparative analysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orthopedics. 2013 Feb;36(2):e179-85. doi: 10.3928/01477447-20130122-20.

            ●● Enlace al texto completo (gratuito o de pago) 3928/01477447-20130122-20

AUTORES / AUTHORS:  - Shin SH; Jeong HJ; Han I; Cho HS; Kim HS

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.

RESUMEN / SUMMARY:  - Osteosarcoma and chondrosarcoma compose most of the primary malignancies of the shoulder. The literature lacks site-specific comparative analyses of these 2 major shoulder sarcomas. The purposes of this study were to describe the different characteristics of the 2 major sarcomas near the glenohumeral joint, examine differences in treatment outcomes, and evaluate the functional outcomes of limb salvage surgery. Thirty-two patients with osteosarcoma or chondrosarcoma  who underwent a wide resection including the glenohumeral joint were enrolled in  this study. The characteristics of tumor development and treatment, oncologic and functional outcomes, and factors affecting outcomes were compared between groups  and with the literature. The results showed shoulder osteosarcoma developing similarly to the literature reports, whereas chondrosarcoma tended to be of a high histologic grade. Nonetheless, the osteosarcoma group had a poorer overall 5-year survival rate (53.0%) than the chondrosarcoma group (85.7%) or those in previous reports. The osteosarcoma group had a tendency toward a worse 5-year metastasis-free survival rate than the chondrosarcoma group (35.4% vs 75.0%, respectively), although the 5-year local recurrence-free survival rate was not significantly different between the 2 groups (75.0% vs 87.5%, respectively). Histologic grade, surgical stage, and chemotherapy affected the oncologic outcomes in univariate analysis, although not a single factor was independent in  multivariate analysis. The functional outcomes were not significantly affected by clinical characteristics or surgical methods in patients who had undergone a wide resection including the glenohumeral joint.

 

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[331]

TÍTULO / TITLE:  - Congenital dermatofibrosarcoma protuberans.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cutis. 2012 Dec;90(6):285-8.

AUTORES / AUTHORS:  - de Morais OO; de Araujo LC; Gomes CM; Coutinho AS; Souza FA; Costa IM

INSTITUCIÓN / INSTITUTION:  - Hospital Universitario de Brasilia, Universidade de Brasilia, Brasil.

RESUMEN / SUMMARY:  - Congenital dermatofibrosarcoma protuberans (DFSP) is a rare dermal and subcutaneous neoplasm of low-grade malignant behavior that is characterized by a  low frequency of metastases with locally invasive growth. Its occurrence at birth and during childhood is rare. We present a case of a patient who was born with a  light brown macule on his right buttock that was misdiagnosed as localized scleroderma. The lesion progressed into reddish atrophic plaques and nodules extending to the iliac region and the gluteal fold. At 5 years of age, a diagnosis of congenital DFSP was made based on clinical and immunohistochemical characteristics (CD34 positivity and spindle cell proliferation). Although there  was a delay in diagnosis, a 3-step excision was proposed with a final step of Mohs micrographic surgery (MMS).

 

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[332]

TÍTULO / TITLE:  - Gastrointestinal stromal tumors in Turkey: experiences from 3 centers.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Onkologie. 2013;36(1-2):18-24. doi: 10.1159/000346673. Epub 2013 Jan 28.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000346673

AUTORES / AUTHORS:  - Selcukbiricik F; Yalcin S; Tural D; Erdamar S; Demir G; Dogusoy G; Mandel NM

INSTITUCIÓN / INSTITUTION:  - Cerrahpasa Faculty of Medicine, Internal Medicine, Medical Oncology, Istanbul University, Istanbul, Turkey. drfatih74@yahoo.com

RESUMEN / SUMMARY:  - BACKGROUND: Gastrointestinal stromal tumors (GIST) are rare tumors of the gastrointestinal system. The most common primary site of GIST is the stomach. The treatment is primarily surgery, and the standard medical therapy is imatinib. Long-term survival can be obtained with good follow-up and treatment. MATERIALS AND METHODS: In this study, data entry was performed using a web-based patient registry system for patients who were referred to 3 centers and retrospectively were diagnosed with GIST. RESULTS: The study cohort consisted of 249 patients, including 160 men (64.3%) and 89 women (35.7%). The mean age was 59 years (range  21-90 years). Initially, 69.9% of the patients had local disease, while 30.1% had metastatic disease. The tumor was located in the stomach in 45.6% of patients. According to the Fletcher risk classification, the very low risk group included 8 subjects (3.2%), the low risk group included 40 subjects (16.1%), the moderate risk group included 56 subjects (22.5%), and the high risk group included 117 subjects (47%); the unspecified group included 28 subjects (11.5%). CONCLUSION: These data are important for revealing the clinicopathologic characteristics and  survival data of patients with GIST, who are treated and followed up in Turkey.

 

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[333]

TÍTULO / TITLE:  - Left Atrial Myxoma on FDG-PET/CT.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Mar 18.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e31827086a3

AUTORES / AUTHORS:  - Gheysens O; Cornillie J; Voigt JU; Bogaert J; Westhovens R

INSTITUCIÓN / INSTITUTION:  - From the Departments of *Nuclear Medicine, daggerRheumatology, double daggerCardiology, and section signRadiology, University Hospital Leuven, Leuven,  Belgium.

RESUMEN / SUMMARY:  - A 56-year-old woman with rheumatoid factor-positive rheumatoid arthritis underwent FDG-PET/CT because of fatigue, fever, coughing, and weight loss for several months. FDG-PET/CT solely revealed a mildly hypermetabolic hypodense area in the left atrium. Subsequently, transthoracic echocardiography and contrast-enhanced MRI showed a left atrial pedunculated soft tissue mass suggestive for myxoma, with histological confirmation. Myocardial involvement by  tumors is rare, and FDG-PET/CT has been very useful for identifying cardiac metastases. However, very few cases have been reported using FDG-PET/CT for detecting primary cardiac tumors, but as shown here, abnormal focal myocardial uptake should trigger further morphological assessment.

 

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[334]

TÍTULO / TITLE:  - A Large Soft-Tissue Lipoma Shown on Bone Scintigraphy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Mar 18.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e31828733d0

AUTORES / AUTHORS:  - Yang H; Miroshnichenko T

INSTITUCIÓN / INSTITUTION:  - From the Department of Radiology/Nuclear Medicine, New York Methodist Hospital, Brooklyn, New York.

RESUMEN / SUMMARY:  - A 74-year-old male patient with a newly diagnosed prostate cancer had whole-body  bone scintigraphy for staging. The images did not demonstrate osseous metastasis. However, there was a large ring-shaped, relatively photopenic region with peripherally increased MDP activity in the left back, which was caused by a large lipoma.

 

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[335]

TÍTULO / TITLE:  - Primary Cardiac Angiosarcoma with Spontaneous Ruptures of the Right Atrium and Right Coronary Artery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Echocardiography. 2013 Mar 12. doi: 10.1111/echo.12176.

            ●● Enlace al texto completo (gratuito o de pago) 1111/echo.12176

AUTORES / AUTHORS:  - Tang K; Shang QL; Zhou QC; Zhou JW; She XL; Zhang M

INSTITUCIÓN / INSTITUTION:  - Department of Ultrasound, the 2nd Xiangya Hospital of Central South University, Hunan, China.

RESUMEN / SUMMARY:  - Primary tumors of the heart are rarely seen. Cardiac angiosarcomas are malignant  tumors that almost always have a poor prognosis. Atrium rupture and coronary artery fistula are very rare complications of primary cardiac angiosarcoma. We describe a 57-year-old man suffering from primary cardiac angiosarcoma with spontaneous ruptures of the right atrium and right coronary artery (RCA). Theoretically, either of these ruptures invariably results in pericardial effusion and tamponade that is rare but potentially life threatening. In this instance, however, the patient might have developed fibrous adhesions resulted from previous bloody pericardial effusion. A massive pericardial effusion was localized, which consequently prevented cardiac tamponade and hemodynamic collapse. Echocardiography revealed the tumor progression leading to detectable infiltration of solid mass into the right atrial (RA) wall, which is close to RCA. And color Doppler displayed the flow into the pericardial cavity through a disrupted RA wall and perforated RCA. Echocardiography remains the primary method of choice for evaluation of cardiac masses.

 

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[336]

TÍTULO / TITLE:  - Urinary Bladder Leiomyosarcoma: Staging With 18F-FDG PET/CT.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Jan 31.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e3182523e33

AUTORES / AUTHORS:  - Makis W; Rakheja R; Nahal A; Hickeson M; Lisbona R

INSTITUCIÓN / INSTITUTION:  - From the *Department of Nuclear Medicine, Brandon Regional Health Centre, Brandon, Manitoba; and daggerDepartment of Nuclear Medicine, Royal Victoria Hospital, and double daggerDepartment of Pathology, Montreal General Hospital, McGill University, Montreal, Quebec, Canada.

RESUMEN / SUMMARY:  - ABSTRACT: A 28-year-old woman with a history of prior bilateral retinoblastoma presented with general fatigue, anemia, and a urinary bladder mass seen on abdominal ultrasound and CT. She was referred for a staging F-FDG PET/CT, which showed an intensely FDG-avid bladder mass that was biopsied to reveal a leiomyosarcoma, with no evidence of metastases, which guided her management. F-FDG PET/CT is routinely used in the evaluation of leiomyosarcomas; however, its use in the staging of a leiomyosarcoma of the urinary bladder has not been previously described in the literature. This case highlights the usefulness of PET/CT in the staging of this rare tumor.

 

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[337]

TÍTULO / TITLE:  - Osteosarcoma Pulmonary Metastasis Mimicking Abnormal Skeletal Uptake in Bone Scan: Utility of SPECT/CT.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Mar 11.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e318266cdcb

AUTORES / AUTHORS:  - Mebarki M; Medjahedi A; Menemani A; Betterki S; Terki S; Berber N

INSTITUCIÓN / INSTITUTION:  - From the Faculty of Medicine, Department of Nuclear Medicine, University Hospital of Tlemcen, Tlemcen, Algeria.

RESUMEN / SUMMARY:  - We present a case of a 15-year-old boy with osteoblastic osteosarcoma of the left distal femur. The patient was referred to bone scan for initial staging.On planar bone scan, there is increased uptake of Tc-MDP (Tc-methylene diphosphonate) in the left distal femur. There are also multiple sites of abnormal tracer uptake projecting to the thoracic cage, initially assumed to be localized in the ribs. SPECT/CT correctly identified them as pulmonary metastases.This case illustrates  the potential advantages and utility of SPECT/CT imaging of skeletal bone scan in order to decide on the optimal treatment.

 

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[338]

TÍTULO / TITLE:  - Primary rhabdomyosarcoma of pulmonary artery: 18F-FDG PET/CT for detecting recurrence in a rare tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Mar;38(3):e155-6. doi: 10.1097/RLU.0b013e31826392dc.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e31826392dc

AUTORES / AUTHORS:  - Suman KC; Sharma P; Singh H; Bal C; Kumar R

INSTITUCIÓN / INSTITUTION:  - Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

RESUMEN / SUMMARY:  - Primary pulmonary artery rhabdomyosarcomas are very rare tumors with a small number of cases reported in the literature. Here we show (18)F-flurodeoxyglucose  (FDG) positron emission tomography-computed tomography (PET/CT) images of a 58-year-old man with left pulmonary artery rhabdomyosarcoma who had undergone surgery for the primary tumor followed by chemotherapy. Restaging FDG PET/CT showed local recurrence and pulmonary metastasis. This case highlights that FDG PET/CT can be useful for restaging rare tumors such as pulmonary artery rhabdomyosarcoma.

 

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[339]

TÍTULO / TITLE:  - Angiomyolipoma of the liver: analysis of typical features and pitfalls based on own experience and literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Mar;37(2):320-6. doi: 10.1016/j.clinimag.2012.05.010. Epub 2012 Jun 21.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.05.010

AUTORES / AUTHORS:  - Anysz-Grodzicka A; Pacho R; Grodzicki M; Koperski L; Gornicka B; Cieszanowski A; Zieniewicz K; Krawczyk M

INSTITUCIÓN / INSTITUTION:  - 2nd Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland. Electronic address: aanyszgrodzicka@gmail.com.

RESUMEN / SUMMARY:  - We present imaging findings (ultrasound, computed tomography, and magnetic resonance imaging) of eight patients with hepatic angiomyolipoma (HAML). The lesions were solitary in seven patients, and one patient had multiple tumors (n=11). Angiomyolipoma, even though a rare liver tumor, should be included in the differential diagnosis in cases of highly vascularized lesion containing a significant amount of fat. Suggestion of the diagnosis of HAML might be helpful for the pathologist in the selection of the typical histochemical staining of the tumor, allowing accurate diagnosis, which, in turn, determines the implementation of appropriate therapeutic intervention.

 

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[340]

TÍTULO / TITLE:  - Radiology-pathology conference: malignant solitary fibrous tumor of the seminal vesicle.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Mar;37(2):409-13. doi: 10.1016/j.clinimag.2012.04.027. Epub 2012 Jun 8.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.04.027

AUTORES / AUTHORS:  - Khandelwal A; Virmani V; Amin MS; George U; Khandelwal K; Gorsi U

INSTITUCIÓN / INSTITUTION:  - Division of Abdominal Radiology, University of Ottawa, Ottawa, Canada. Electronic address: drashish83@gmail.com.

RESUMEN / SUMMARY:  - Mesenchymal neoplasms are rarely encountered in the seminal vesicle. Only four cases of the seminal vesicle solitary fibrous tumor have been reported in English literature, all of which were benign in nature. We are describing the clinicoradiological and pathological features of a locally aggressive malignant solitary fibrous tumor arising from the seminal vesicle, which posed the therapeutic challenge for the surgical management in a 52-year-old male patient.  To our knowledge, this is the first reported case of the malignant solitary fibrous tumor arising from the seminal vesicle.

 

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[341]

TÍTULO / TITLE:  - Low-Grade, Metastasizing Splenic Littoral Cell Angiosarcoma Presenting With Hepatic Cirrhosis and Splenic Artery Aneurysm.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Pathol. 2013 Feb 19.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1066896913476737

AUTORES / AUTHORS:  - Larsen BT; Bishop MC; Hunter GC; Renner SW

RESUMEN / SUMMARY:  - The behavior of littoral cell neoplasms ranges from benign (littoral cell angioma, LCA) to highly malignant (angiosarcoma). Two unusual cases of low-grade  metastatic littoral cell angiosarcoma (LCAS) have been reported with late recurrence and bulky metastases. We present the third case of this rare neoplasm  in a 38-year-old man with cirrhosis and a large splenic artery aneurysm, without  extrasplenic masses. The spleen showed nodules resembling LCA, immunoreactive for CD31, factor VIII, CD68, and CD163 but not CD8 or CD34. Also present were solid areas of immunophenotypically identical bland spindle cells, although lighter CD31 immunostaining distinguished them from LCA-like angiomatous channels. Similar cells diffusely infiltrated the cirrhotic liver. After splenectomy, pancytopenia resolved, and he is asymptomatic 19 months later. Low-grade LCAS is  a previously unreported cause of cirrhosis and may metastasize without forming masses. In cases of LCA, CD31 immunohistochemistry may facilitate detection of LCAS and indicate metastatic potential.

 

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[342]

TÍTULO / TITLE:  - Dedifferentiated Liposarcoma of the Retroperitoneum With Osteosarcomatous Component.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Pathol. 2013 Feb 19.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1066896913476749

AUTORES / AUTHORS:  - Aurello P; Virgilio E; Sirimarco D; Novi L; D’Angelo F; Ramacciato G

 

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[343]

TÍTULO / TITLE:  - Parathyroid Carcinosarcoma: A Rare Parathyroid Carcinoma With Normal Parathyroid  Hormone Levels.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Pathol. 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1066896913480830

AUTORES / AUTHORS:  - Taggartj J; Summerlin DJ; Moore MG

INSTITUCIÓN / INSTITUTION:  - Indiana University School of Medicine, Indianapolis, IN, USA.

RESUMEN / SUMMARY:  - Parathyroid carcinosarcoma was first described by Nacamuli et al in 2002. We present the second case of this rare disease. This rare carcinosarmoca presented  as a parathyroid carcinoma with uncharacteristically normal parathyroid hormone levels. The patient is a 57-year-old woman with long-standing right-sided vocal cord paralysis presented with a progressive 3 x 2 x 3 cm mass in the right neck.  She had previously undergone a total thyroidectomy revealing benign pathology. Parathyroid hormone and calcium blood levels were within normal limits. The mass  was removed with negative surgical margins. Histopathology and immunohistochemical analysis showed a biphasic pattern, with positive for chromogranin and vimentin, consistent with carcinoma and sarcoma. The disease in  our patient, as in the previously reported case, has shown systemic progression despite aggressive surgical resection and adjuvant therapy.

 

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[344]

TÍTULO / TITLE:  - CORAL: Classification Model for Predictions of Anti-Sarcoma Activity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Curr Top Med Chem. 2012 Dec 1;12(24):2741-4.

AUTORES / AUTHORS:  - Toropov AA; Toropova AP; Benfenati E; Gini G; Leszczynska D; Leszczynski J

INSTITUCIÓN / INSTITUTION:  - Istituto di Ricerche Farmacologiche Mario Negri, 20156, Via La Masa 19, Milano, Italy. andrey.toropov@marionegri.it.

RESUMEN / SUMMARY:  - A modified version of the CORAL software (insilico.eu/coral) allows building up the classification model for the case of the Yes/No data on the anti-sarcoma activity of organic compounds. Three random splits into the sub-training, calibration, and test sets of the data for 3017 compounds were examined. The performance of the proposed approach is satisfactory. The average values of the statistical characteristics for external test set on three random splits are as follows: n=1173-1234, sensitivity = 0.8903+/-0.0390, specificity =  0.9869+/-0.0013, and accuracy = 0.9759+/-0.0043. Mechanistic interpretation of the suggested model is discussed.

 

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[345]

TÍTULO / TITLE:  - Unplanned excision of soft tissue sarcoma: The impact of the referring hospital.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Surg Oncol. 2013 Mar 15. pii: S0960-7404(13)00024-8. doi: 10.1016/j.suronc.2013.02.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.suronc.2013.02.006

AUTORES / AUTHORS:  - Kang S; Han I; Lee SA; Cho HS; Kim HS

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, Seoul 110-744, Republic of Korea. Electronic address: ziozio79@daum.net.

RESUMEN / SUMMARY:  - BACKGROUND: : Unplanned excision of soft tissue sarcoma (STS) remains a common problem performed at various levels of hospitals, where clinical characteristics  may differ. However, there is little literature describing the impact of the referring hospital on patient characteristics and/or outcome in unplanned excision of STS. This study examined the possible different patient characteristics and prognoses according to the level of referring hospitals where unplanned excision was performed. METHODS: : Patients referred to our institute after unplanned excision of STS on their extremities were reviewed. Referring hospitals were categorized into two groups according to their referral grades; tertiary hospitals (general hospitals with tertiary [highest] referral grade, n = 42) and non-tertiary hospitals (others, n = 79). RESULTS: : Patients referred from tertiary hospitals had significantly larger number of high-grade tumors (p = 0.019) but lower chance of finding a residual tumor at re-excision (p = 0.020) than non-tertiary hospitals. For oncological outcomes, referral from tertiary hospital was an independent factor for better local control (hazard ratio, 0.211; 95% confidence interval, 0.061-0.730). However, there was no difference in disease-specific death (p = 0.729) or metastasis (p = 0.978) between the two groups. CONCLUSIONS: : Despite having worse clinicopathologic characteristics, patients referred from tertiary hospitals had fewer local recurrences than patients from non-tertiary hospitals. The impact of the referring hospital on patient outcome and disease characteristics needs to be considered in unplanned excision of STS.

 

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[346]

TÍTULO / TITLE:  - Finding an optimum immuno-histochemical feature set to distinguish benign phyllodes from fibroadenoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Micron. 2013 Feb 22. pii: S0968-4328(13)00025-5. doi: 10.1016/j.micron.2013.02.004.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.micron.2013.02.004

AUTORES / AUTHORS:  - Maity PP; Chatterjee S; Das RK; Mukhopadhyay S; Maity A; Maulik D; Ray AK; Dhara S; Chatterjee J

INSTITUCIÓN / INSTITUTION:  - School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India.

RESUMEN / SUMMARY:  - PURPOSE: Benign phyllodes and fibroadenoma are two well-known breast tumors with  remarkable diagnostic ambiguity. The present study is aimed at determining an optimum set of immuno-histochemical features to distinguish them by analyzing important observations on expressions of important genes in fibro-glandular tissue. METHODS: Immuno-histochemically, the expressions of p63 and alpha-SMA in  myoepithelial cells and collagen I, III and CD105 in stroma of tumors and their normal counterpart were studied. Semi-quantified features were analyzed primarily by ANOVA and ranked through F-scores for understanding relative importance of group of features in discriminating three classes followed by reduction in F-score arranged feature space dimension and application of inter-class Bhattacharyya distances to distinguish tumors with an optimum set of features. RESULTS: Among thirteen studied features except one all differed significantly in three study classes. F-Ranking of features revealed highest discriminative potential of collagen III (initial region). F-Score arranged feature space dimension and application of Bhattacharyya distance gave rise to a feature set of lower dimension which can discriminate benign phyllodes and fibroadenoma effectively. CONCLUSIONS: The work definitely separated normal breast, fibroadenoma and benign phyllodes, through an optimal set of immuno-histochemical features which are not only useful to address diagnostic ambiguity of the tumors  but also to spell about malignant potentiality.

 

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[347]

TÍTULO / TITLE:  - Intramedullary spinal metastasis of a gastrointestinal leiomyosarcoma without vertebral bone lesions.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neurol Sci. 2013 Mar 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10072-013-1341-9

AUTORES / AUTHORS:  - Helmchen C; Greggersen W; Geaid A; Nowak G; Bos I; Petersen D

INSTITUCIÓN / INSTITUTION:  - Department of Neurology, University Hospitals Schleswig-Holstein, Luebeck, Germany, christoph.helmchen@neuro.uni-luebeck.de.

 

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[348]

TÍTULO / TITLE:  - Case of leptosuccin induced malignant hyperthermia in a patient with GIST of the  rectum.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Chir Iugosl. 2012;59(2):121-3.

AUTORES / AUTHORS:  - Natasa N; Snezana P; Nemanja Z; Zoran K; Durasic L

INSTITUCIÓN / INSTITUTION:  - Center for anesthesiology and reanimatology, Clinical Center of Serbia.

RESUMEN / SUMMARY:  - Malignant hyperthermia (MH) is a form of myopathy that is usually triggered by volatile anaesthetics such as halothane, sevoflurane and desflurane and depolarising muscle relaxants such as succinylcholine. Pathologic response in MH  include increase in oxygen consumption, increase in endtidal CO2, tachycardia, hyperthermia, hyperkalemia and muscle rigidity. Immediate recognition and treatment are crucial to avoid lethal outcome. Molecular genetic studies have confirmed that ryanodine muscle receptors are responsible for MH. We present a case of leptosuccin induced MH with masseter muscle rigidity, mild pCO2 increase  (6.3 kPa), elevated body temperature measured with esophageal temperature probe (39.5 degrees C), tachycardia (115 beats/min) and respiratory and metabolic acidosis (pH was 7,23) in a patient who underwent low anterior resection of the rectum for gastrointestinal stromal tumor (GIST) of the rectum.

 

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[349]

TÍTULO / TITLE:  - Epithelioid PEComa (epithelioid angiomyolipoma) of the kidney: a rare tumor subtype for patients presenting with an enhancing renal mass.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Can J Urol. 2013 Feb;20(1):6643-5.

AUTORES / AUTHORS:  - Shrewsberry AB; Sica GL; Osunkoya AO; Canter DJ

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

RESUMEN / SUMMARY:  - Epithelioid angiomyolipomas, or perivascular epithelioid cell tumors (epithelioid PEComas) of the kidney, are histologically related to renal angiomyolipomas (AMLs). However, in contrast to typical AMLs, this rare tumor can exhibit an aggressive clinical course with approximately 50% of reported cases demonstrating disease progression. In this report, we present a case of a 24-year-old female with a history of stone disease who was incidentally found to have a 9.0 cm right renal mass that was difficult to characterize radiographically preoperatively. The patient underwent a right radical nephrectomy, and pathology revealed a renal epithelioid PEComa.

 

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[350]

TÍTULO / TITLE:  - Survival following disease recurrence of primary localized alveolar rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2013 Feb 15. doi: 10.1002/pbc.24488.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24488

AUTORES / AUTHORS:  - Dantonello TM; Int-Veen C; Schuck A; Seitz G; Leuschner I; Nathrath M; Schlegel PG; Kontny U; Behnisch W; Veit-Friedrich I; Kube S; Hallmen E; Kazanowska B; Ladenstein R; Paulussen M; Ljungman G; Bielack SS; Klingebiel T; Koscielniak E

INSTITUCIÓN / INSTITUTION:  - Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology, Rheumatology, Gastroenterology, and General Pediatrics), Klinikum Stuttgart, Stuttgart, Germany. tobias.dantonello@olgahospital-stuttgart.de, t.dantonello@klinikum-stuttgart.de.

RESUMEN / SUMMARY:  - BACKGROUND: Recurrences in primary localized alveolar rhabdomyosarcoma (RMA) are  common. Post-relapse survival is poor. We evaluated prognostic factors including  relapse treatment in patients with recurrent RMA. METHODS: Relapses occurred in 115/235 patients with nonmetastatic RMA treated in four consecutive CWS-trials after achievement of a complete remission. Sufficient information about post-relapse treatment and outcome could be obtained in 99 patients and was retrospectively analyzed. RESULTS: Nine of 99 patients received no salvage therapy and died after a median of 2 months. The remaining 90 patients received multimodal relapse treatment including mandatory chemotherapy. Recurrences were grossly resected in 39 patients; 57 patients received radiation. At a median follow-up from relapse of 8 years, 20 patients were alive and disease-free (5-year post-relapse survival [PROS] 21.3 +/- 8). All surviving patients apart from a single individual had an isolated, circumscribed recurrence. Sixteen of 20 survivors were treated with adequate local relapse therapy (ALRT, i.e., either complete resection or gross resection + radiation). Survival in the subgroup of 27 individuals with circumscribed recurrences and ALRT was significantly better (PROS 53.7 +/- 19) compared with disseminated recurrences and/or tumors treated without ALRT. Absence of primary lymph node involvement, circumscribed relapses,  ALRT, and achievement of a second CR were identified as independent favorable risk factors. CONCLUSION: Post-relapse survival for primary localized RMA is generally poor. However, certain patient groups differed significantly in their likelihood of survival and 50% of patients with circumscribed relapses treated with ALRT survived. These findings may form the basis for an evidence-based risk-stratification for recurrent disease including relapse treatment. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.

 

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[351]

TÍTULO / TITLE:  - Analysis of immediate vascular reconstruction for lower-limb salvage in patients  with lower-limb bone and soft-tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Plast Reconstr Aesthet Surg. 2013 May;66(5):608-16. doi: 10.1016/j.bjps.2013.01.001. Epub 2013 Feb 5.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bjps.2013.01.001

AUTORES / AUTHORS:  - Umezawa H; Sakuraba M; Miyamoto S; Nagamatsu S; Kayano S; Taji M

INSTITUCIÓN / INSTITUTION:  - Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo, Japan; Division of Plastic and Reconstructive Surgery, National Cancer Center Hospital, Tokyo, Japan. Electronic address: s8013@nms.ac.jp.

RESUMEN / SUMMARY:  - BACKGROUND: Limb amputation has historically been the first choice of treatment for patients with bone or soft-tissue sarcomas involving major blood vessels. However, recent advances in surgical technique have allowed limb-salvage surgery. We reviewed our experiences with limb-salvage surgery and immediate vascular reconstruction following en bloc resection of bone or soft-tissue sarcomas of the lower extremity. MATERIALS AND METHOD: We reviewed 23 patients (15 male and eight female; mean age, 43.6 years) who underwent limb-salvage surgery and immediate vascular reconstruction. Details of surgical factors and postoperative complications were evaluated. RESULTS: Reconstructed vessels remained patent in 21 cases. The rate of limb oedema was higher in patients who underwent only arterial reconstruction after arteriovenous resection. Twenty patients could walk well without crutches a few months after reconstructive surgery. All patients avoided amputation. Two patients died of disseminated disease within 3 years after surgery. CONCLUSION: The high rate of limb oedema suggests that venous reconstruction is necessary after arteriovenous resection. Vascular reconstruction and musculocutaneous flap techniques are useful in limb-salvage surgery and are indicated for patients who have achieved good disease control. Evidence Rating Scale for Therapeutic Studies: Level III.

 

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[352]

TÍTULO / TITLE:  - Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: an analysis of 181 patients of the French ATU compassionate use program.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - BMC Cancer. 2013 Feb 6;13(1):64.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1471-2407-13-64

AUTORES / AUTHORS:  - Blay JY; Italiano A; Ray-Coquard I; Cesne A; Duffaud F; Rios M; Collard O; Bertucci F; Bompas E; Isambert N; Chaigneau L; Cassier P; Bui B; Decanter G; Derbel O; Coindre JM; Zintl P; Badri N; Penel N

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: The long term outcome of advanced sarcoma patients treated  with trabectedin outside of clinical trials and the utility of maintenance treatment has not been reported. METHODS: Between 2003 and 2008, patients with advanced sarcoma failing doxorubicin could be treated within a compassionate use  program (ATU, Temporary Use Authorization) of trabectedin in France using the standard 3-weekly regimen. Data from 181 patients (55%) were collected from 11 centres and analyzed. RESULTS: Trabectedin was given in first, second, third or fourth line in metastatic phase in 6%, 37%, 33% and 23% of patients respectively. With a median follow-up of 6 years, median PFS and OS were 3.6 months and 16.1 months respectively. The median number of cycles was 3 (range 1--19). Best response were partial response (PR, n = 18, 10%), stable disease (SD, n = 69, 39%) and progressive disease (PD, n = 83, 46%), non evaluable (NE, n = 9, 5%). Thirty patients (17%) had to be hospitalized for treatment- related side effects. Independent prognostic factors in multivariate analysis (Cox model) were myxoid LPS and line of trabectedin for PFS, and myxoid LPS and retroperitoneal sarcomas  for OS. Patients in PR or SD after 6 cycles continuing treatment had a better PFS (median 5.3 vs 10.5 months, p = 0.001) and OS (median 13.9 vs 33.4 months, p = 0.009) as compared to patients who stopped after 6 cycles. CONCLUSIONS: In this compassionate use program, trabectedin yielded similar or better PFS and OS than  in clinical trials. Maintenance treatment beyond 6 cycles was associated with an  improved survival.

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[353]

TÍTULO / TITLE:  - Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Sci. 2013 Feb 19. doi: 10.1111/cas.12133.

            ●● Enlace al texto completo (gratuito o de pago) 1111/cas.12133

AUTORES / AUTHORS:  - Takeuchi A; Yamamoto Y; Munesue S; Harashima A; Watanabe T; Yonekura H; Yamamoto H; Tsuchiya H

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

RESUMEN / SUMMARY:  - The receptor for advanced glycation end products (RAGE) is a pattern-recognition  receptor and its engagement by ligands such as high mobility group box 1 (HMGB1)  is implicated in tumor growth and metastasis. Low molecular weight heparin (LMWH) has an antagonistic effect on the RAGE axis and is also reported to exert an antitumor effect beyond the known activity of anticoagulation. However, the link  between the anti-RAGE and antitumor activities of LMWH has not yet to be fully elucidated. In this study, we investigated whether LMWH could inhibit tumor cell  proliferation, invasion, and metastasis by blocking the RAGE axis using in vitro  and in vivo assay systems. Stably transformed HT1080 human fibrosarcoma cell lines were obtained, including human full-length RAGE-overexpressing (HT1080RAGE  ), RAGE dominant-negative, intracellular tail-deleted RAGE-overexpressing (HT1080dnRAGE ), and mock-transfected control (HT1080mock ) cells. Confocal microscopy showed the expression of HMGB1 and RAGE in HT1080 cells. The LMWH significantly inhibited HMGB1-induced NFkappaB activation through RAGE using an NFkappaB-dependent luciferase reporter assay and the HT1080 cell lines. Overexpression of RAGE significantly accelerated, but dnRAGE expression attenuated HT1080 cell proliferation and invasion in vitro, along with similar effects on local tumor mass growth and lung metastasis in vivo. Treatment with LMWH significantly inhibited the migration, invasion, tumor formation, and lung metastasis of HT1080RAGE cells, but not of HT1080mock or HT1080dnRAGE cells. In conclusion, this study revealed that RAGE exacerbated the malignant phenotype of  human fibrosarcoma cells, and that this exacerbation could be ameliorated by LMWH. It is suggested that LMWH has therapeutic potential in patients with certain types of malignant tumors.

 

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[354]

TÍTULO / TITLE:  - Role of macrophage targeting in the antitumor activity of trabectedin.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Cell. 2013 Feb 11;23(2):249-62. doi: 10.1016/j.ccr.2013.01.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ccr.2013.01.008

AUTORES / AUTHORS:  - Germano G; Frapolli R; Belgiovine C; Anselmo A; Pesce S; Liguori M; Erba E; Uboldi S; Zucchetti M; Pasqualini F; Nebuloni M; van Rooijen N; Mortarini R; Beltrame L; Marchini S; Fuso Nerini I; Sanfilippo R; Casali PG; Pilotti S; Galmarini CM; Anichini A; Mantovani A; D’Incalci M; Allavena P

INSTITUCIÓN / INSTITUTION:  - Department Immunology and Inflammation, IRCCS Clinical and Research Institute Humanitas, 20089 Rozzano, Milan, Italy.

RESUMEN / SUMMARY:  - There is widespread interest in macrophages as a therapeutic target in cancer. Here, we demonstrate that trabectedin, a recently approved chemotherapeutic agent, induces rapid apoptosis exclusively in mononuclear phagocytes. In four mouse tumor models, trabectedin caused selective depletion of monocytes/macrophages in blood, spleens, and tumors, with an associated reduction of angiogenesis. By using trabectedin-resistant tumor cells and myeloid cell transfer or depletion experiments, we demonstrate that cytotoxicity on mononuclear phagocytes is a key component of its antitumor activity. Monocyte depletion, including tumor-associated macrophages, was observed in treated tumor  patients. Trabectedin activates caspase-8-dependent apoptosis; selectivity for monocytes versus neutrophils and lymphocytes is due to differential expression of signaling and decoy TRAIL receptors. This unexpected property may be exploited in different therapeutic strategies.

 

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[355]

TÍTULO / TITLE:  - Clinical Characteristics and Outcomes of HIV-Infected Children Diagnosed With Kaposi Sarcoma in Malawi and Botswana.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2013 Mar 11. doi: 10.1002/pbc.24516.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24516

AUTORES / AUTHORS:  - Cox CM; El-Mallawany NK; Kabue M; Kovarik C; Schutze GE; Kazembe PN; Mehta PS

INSTITUCIÓN / INSTITUTION:  - Baylor College of Medicine International Pediatric AIDS Initiative at Texas Children’s Hospital, Houston, Texas.

RESUMEN / SUMMARY:  - BACKGROUND: Kaposi sarcoma (KS) is the most common HIV-associated malignancy in sub-Saharan Africa. The presentation and outcomes of pediatric KS are not well understood. PROCEDURE: We performed a retrospective cohort analysis of 81 HIV-infected children with KS at the Baylor Children’s Clinical Centres of Excellence in Malawi and Botswana from March 2003 to October 2009. RESULTS: Eighty-one children with KS were identified whose median age was 8.0 (inter-quartile range 5.1-11.3) years. KS lesions were presented primarily on the skin (83%), lymph nodes (52%), and oral mucosa (41%). Occasionally disease was limited to the lymph nodes only (10%). Severe immunosuppression (70%), anemia (29%), and thrombocytopenia (17%) were common laboratory findings. Highly active  antiretroviral therapy (HAART) was administered to 94% of children, including 77% who received HAART plus chemotherapy. KS immune reconstitution inflammatory syndrome (IRIS) occurred in 22%. Disease status 12 months after KS diagnosis was  determined for 69 children: 43% were alive and 57% had died. Severe immunosuppression was independently associated with mortality in multivariate analysis (OR = 4.3; 95% CI 1.3-14.6; P = 0.02). CONCLUSION: KS occurs in a significant number of HIV infected children in sub-Saharan Africa. Pediatric KS is distinct from KS in adults. Lymph node involvement was a common manifestation  of KS in children, and severe immunosuppression was associated with the highest mortality risk. Though overall mortality was high in children with KS, patients did achieve clinical remission in settings with limited diagnostic and therapeutic resources. Pediatr Blood Cancer 2013;9999:XX-XX. © 2013 Wiley Periodicals, Inc.

 

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[356]

TÍTULO / TITLE:  - Low ING4 protein expression detected by paraffin-section immunohistochemistry is  associated with poor prognosis in untreated patients with gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gastric Cancer. 2013 Mar 16.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10120-013-0248-8

AUTORES / AUTHORS:  - Nanding A; Tang L; Cai L; Chen H; Geng J; Liu X; Ning X; Li X; Zhang Q

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, The Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Street, Harbin, 150040, China.

RESUMEN / SUMMARY:  - BACKGROUND: Inhibitor of growth 4 (ING4) has deserved attention as a tumor suppressor gene in many malignant tumors. In our study, we investigated ING4 immunoexpression in gastrointestinal stromal tumors (GISTs) and its prognostic value. METHOD: The expression of ING4 and Ki67 was investigated in 41 samples of  various risk gastrointestinal stromal tumors by immunohistochemical technique. The associations of ING4 expression and clinicopathological parameters, and prognosis of the patients, were analyzed by multivariate Cox regression analysis. RESULTS: ING4 expression showed a decreased trend from lower-risk to high-risk gastrointestinal stromal tumors, and an opposite trend for Ki67 expression. In lower-risk tumors, it was found the expression level of ING4 was 78.95 % +/- 27.90 % and that of Ki67 was 4.42 % +/- 3.75 %. However, in high-risk tumors, the expression level of ING4 was 9.23 % +/- 7.66 % and that of Ki67 was 18.50 % +/- 9.09 %. There was a strongly negative correlation between the expression levels of ING4 and Ki67. A significant difference was observed in the expression of ING4 between invasion and non-invasion (p < 0.001). The expression of ING4 was markedly correlated with tumor size (p < 0.001), mitotic index (p < 0.001), tumor necrosis (p = 0.021), invasion (p < 0.001), recurrence and metastasis (p = 0.021), and mortality (p < 0.001). CONCLUSION: The low expression level of ING4 protein was correlated with high-risk GISTs. ING4 might be involved in the progression of GISTs and inhibit its invasion. ING4 might be one of the prognostic indicators in GISTs.

 

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[357]

- CASTELLANO -

TÍTULO / TITLE:Gastrointestinale Stromatumoren: Empfehlungen fur Diagnose, Behandlung und Nachsorge in Osterreich.

TÍTULO / TITLE:  - Gastrointestinal stromal tumors: Diagnosis, therapy and follow-up care in Austria.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Wien Med Wochenschr. 2013 Mar;163(5-6):137-152. Epub 2013 Mar 19.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10354-013-0187-3

AUTORES / AUTHORS:  - Bareck E; Ba-Ssalamah A; Brodowicz T; Eisterer W; Hafner M; Hogenauer C; Kastner U; Kuhr T; Langle F; Liegl-Atzwanger B; Schoppmann SF; Widmann G; Wrba F; Zacherl J; Ploner F

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, General Hospital, Wiener Neustadt, Vienna, Austria, evelyne.bareck@wienerneustadt.lknoe.at.

RESUMEN / SUMMARY:  - Optimal treatment for patients suffering from gastrointestinal stromal tumors (GIST) is based on an interdisciplinary treatment approach. Austrian representatives of Medical and Surgical Oncology, Pathology, Radiology, Nuclear Medicine, Gastroenterology, and Laboratory Medicine issued this manuscript on a consensual base within the context of currently available and published literature. This paper contains guidelines and recommendations for diagnosis, therapy, and follow-up of GIST patients in Austria.

 

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[358]

TÍTULO / TITLE:  - PAX-FOXO1 Fusion Status Drives Unfavorable Outcome for Children With Rhabdomyosarcoma: A Children’s Oncology Group Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2013 Mar 22. doi: 10.1002/pbc.24532.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24532

AUTORES / AUTHORS:  - Skapek SX; Anderson J; Barr FG; Bridge JA; Gastier-Foster JM; Parham DM; Rudzinski ER; Triche T; Hawkins DS

INSTITUCIÓN / INSTITUTION:  - Children’s Medical Center and University of Texas Southwestern Medical Center, Dallas, Texas.

RESUMEN / SUMMARY:  - BACKGROUND: Rhabdomyosarcoma (RMS) is divided into two major histological subtypes: alveolar (ARMS) and embryonal (ERMS), with most ARMS expressing one of  two oncogenic genes fusing PAX3 or PAX7 with FOXO1 (P3F and P7F, respectively). The Children’s Oncology Group (COG) carried out a multi-institutional clinical trial to evaluate the prognostic value of PAX-FOXO1 fusion status. METHODS: Study participants were treated on COG protocol D9803 for intermediate risk ARMS or ERMS using multi-agent chemotherapy, radiotherapy, and surgery. Central diagnostic pathology review and molecular testing for fusion genes were carried out on prospectively collected specimens. Event-free (EFS) and overall survival (OS) at 5 years were correlated with histological subtype and PAX-FOXO1 status. RESULTS: Of 616 eligible D9803 enrollees, 434 cases had adequate clinical, molecular, and pathology data for definitive classification as ERMS, ARMS P3F+ or P7F+, or ARMSn (without detectable fusion). EFS was worse for those with ARMS P3F+ (54%) and P7F+ (65%) than those with ERMS (77%; P < 0.001). EFS for ARMSn and ERMS were not statistically different (90% vs. 77%, P = 0.15). ARMS P3F+ had  poorer OS (64%) than ARMS P7F+ (87%), ARMSn (89%), and ERMS (82%; P = 0.006). CONCLUSIONS: ARMSn has an outcome similar to ERMS and superior EFS compared to ARMS with either P3F or P7F, when given therapy designed for children with intermediate risk RMS. This prospective analysis supports incorporation of PAX-FOXO1 fusion status into risk stratification and treatment allocation. Pediatr Blood Cancer 2013;9999:XX-XX. © 2013 Wiley Periodicals, Inc.

 

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[359]

TÍTULO / TITLE:  - Chloroma of Pancreas-Initial Manifestation of a Secondary Leukemia after Stem Cell Transplantation Case Report and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Surg. 2013 Feb 16.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11605-013-2166-9

AUTORES / AUTHORS:  - Tabriz N; Tannapfel A; Griesinger F; Weyhe D

INSTITUCIÓN / INSTITUTION:  - Department of Visceral Surgery, Pius-Hospital Oldenburg, Georgstrasse 12, 26121,  Oldenburg, Germany, ntabriz@gmx.de.

RESUMEN / SUMMARY:  - INTRODUCTION: Chloroma is an extramedullary solid tumor consisting of immature myeloid cells. CASE PRESENTATION: We report a patient with painless jaundice 6 years after allogeneic peripheral stem cell transplantation because of an acute myeloid leukemia leading us to the diagnosis of a chloroma of the pancreas as the first manifestation of a secondary host leukemia. DISCUSSION: A histological examination of unclear pancreatic tumors should be mandatory in patients with a history of leukemia. If surgical therapy is unavoidable because of stenosis symptoms or for histological proof, a resection should be avoided. CONCLUSION: Bypass surgery can ease the symptoms and it allows timely curative chemotherapy or stem cell transplantation.

 

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[360]

TÍTULO / TITLE:  - Association of Genetic Variations in RTN4 3’-UTR with Risk of Uterine Leiomyomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Oncol Res. 2013 Mar 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12253-013-9604-6

AUTORES / AUTHORS:  - Zhang K; Bai P; Shi S; Zhou B; Wang Y; Song Y; Rao L; Zhang L

INSTITUCIÓN / INSTITUTION:  - Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China.

RESUMEN / SUMMARY:  - This pilot case-control study was conducted to test the hypothesis that the TATC  (rs71682890) and CAA (rs34917480) insertion/deletion polymorphisms of RTN4 3’-UTR are associated with the susceptibility to uterine leiomyoma (UL). The study recruited 286 premenopausal women with UL and 450 unrelated postmenopausal women  not presenting the disease as control subjects. The polymorphisms of rs71682890 and rs34917480 were genotyped with the method of polymerase chain reaction polyacrylamide gel electrophoresis (PCR - PAGE). No statistically significant association was observed between the TATC insertion/deletion polymorphism and UL  risk. However, increased UL risk was identified to be significantly associated with CAA insertion/deletion polymorphism in the recessive and codominant model. The present study provided evidence for the first time that CAA polymorphism in RTN4 3’-UTR, but not TATC polymorphism may be involved in susceptibility to UL.

 

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[361]

TÍTULO / TITLE:  - Outpatient uterine artery embolization for symptomatic fibroids: short- and long-term single institution-based outcomes.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Obstet Gynaecol Can. 2013 Feb;35(2):156-63.

AUTORES / AUTHORS:  - Rasuli P; Sabri A; Hammond I; French GJ; Gamache N; Jolly EE

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic Imaging, University of Ottawa, The Ottawa Hospital, Ottawa ON.

RESUMEN / SUMMARY:  - Objective: To assess the short- and long-term efficacy and safety of uterine artery embolization (UAE) in the management of uterine fibroids, and to assess patient satisfaction with this procedure when performed on an outpatient basis. Methods: One hundred one patients who had undergone UAE for symptomatic uterine fibroids in the past five years were interviewed over the telephone, using a standard uterine fibroid symptom and quality-of-life questionnaire. The severity  of post-procedural pain, occurrence of adverse reactions, complications, need for subsequent hysterectomy or myomectomy, and overall patient satisfaction were also recorded. Results: UAE resulted in a mean 39.1 point improvement in fibroid symptom scores and a mean rise of health-related quality of life score to 93.6, which is near normal. The mean pain score was highest (3.7/10) on the first night after the procedure. Ten patients returned to the hospital in the first 48 hours  after UAE, but of these only one required admission because of sepsis. The only other major complication was spontaneous fibroid expulsion in one patient. Fourteen patients remained hypermenorrheic, 78 had regained normal or light menses, five reported spotting, and four became amenorrheic. Six patients underwent subsequent hysterectomy and one a subsequent myomectomy. Six patients found the procedure less than satisfactory. Conclusion: UAE is a safe, effective, and durable alternative to hysterectomy and myomectomy in women with symptomatic  fibroids who wish to avoid surgery. It can be performed safely on an outpatient basis.

 

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[362]

TÍTULO / TITLE:  - Multimodality treatment of two cases of intracardiac leiomyomatosis with enormous mass in the abdominopelvic cavity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Expert Rev Anticancer Ther. 2013 Feb;13(2):137-41. doi: 10.1586/era.12.145.

            ●● Enlace al texto completo (gratuito o de pago) 1586/era.12.145

AUTORES / AUTHORS:  - Zhang Y; Zhu J; Wang C; Tu R; Jiang J; Lu W

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin  Road, Shanghai 200032, Shanghai, China.

RESUMEN / SUMMARY:  - Difficulties in the preoperative preparation and surgical management of patients  with intravenous leiomyomatosis involving the heart and pulmonary artery resulting in intracardiac leiomyomatosis necessitate further investigation of this condition. In this report, we describe the interdisciplinary treatment of two cases of intracardiac leiomyomatosis with enormous mass in the abdominopelvic cavity. A single-stage surgical procedure with a combined thoracic and abdominal  approach was performed in both cases and the tumors were successfully excised. The procedure also involved removal of the atrial, caval and other venular extensions, and total hysterectomy with bilateral salpingo-oophorectomy. Postoperative pathology findings confirmed the diagnosis of intravenous leiomyomatosis. Neither patient died perioperatively, and no complications were observed.

 

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[363]

TÍTULO / TITLE:  - Comparison of pregnancy outcomes in different localizations of uterine fibroids.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Exp Obstet Gynecol. 2012;39(4):516-8.

AUTORES / AUTHORS:  - Deveer M; Deveer R; Engin-Ustun Y; Sarikaya E; Akbaba E; Senturk B; Danisman N

INSTITUCIÓN / INSTITUTION:  - Department of Radiology Dr. Nafiz, Zekai Tahir Burak Women’s Health Research Hospital, Ankara, Turkey. deveer3@hotmail.com

RESUMEN / SUMMARY:  - OBJECTIVE: The basic aim of this study is to compare the pregnancy outcomes in cases with uterine fibroids located at the anterior and posterior uterine walls.  MATERIALS AND METHODS: A total of 84 pregnant women with a diagnosis of uterine myoma larger than 30 millimeter (mm) in diameter were included in the study to determine the obstetric outcomes. In 64 (76.20%) patients, myomas were detected at the anterior uterine wall (group 1), while 20 (23.80%) were detected at the posterior uterine wall (group 2). All patients were followed monthly until the end of pregnancy. Demographic and obstetric characteristics were compared between the two groups. RESULTS: There were no significant differences in age, gravida, parity, and myoma size between the two groups. A significant difference existed between the groups with regard to pelvic pain. Posterior located fibroids were associated with more pelvic pain (p = 0.001). No difference was observed between  the two groups with regard to the rates of preterm delivery, bleeding in early pregnancy, infants with small for gestational age, and hospitalization period during pregnancy. Women with posterior located myomas had significantly higher miscarriage rates. CONCLUSION: Our findings suggest that pregnancies with uterine fibroids are at increased risk for complications. Posterior located fibroids larger than 30 mm in diameter are associated with severe pelvic pain compared to  anterior located fibroids.

 

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[364]

TÍTULO / TITLE:  - A Case Study of Personalized Therapy for Osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2013 Mar 22. doi: 10.1002/pbc.24512.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24512

AUTORES / AUTHORS:  - Davis LE; Hofmann NE; Li G; Huang ET; Loriaux MM; Bracha S; Helfand SC; Mata JE; Marley K; Mansoor A; Tyner JW; Abraham J; Seguin B; Keller C

INSTITUCIÓN / INSTITUTION:  - Pediatric Cancer Biology Program, Pape Family Pediatric Research Institute, Oregon Health & Sciences University, Portland, Oregon; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Oregon Health & Sciences University, Portland, Oregon; Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Sciences University, Portland, Oregon; Knight Cancer Institute, Oregon Health & Sciences University, Portland, Oregon.

RESUMEN / SUMMARY:  - BACKGROUND: Effective targeted therapies are needed in sarcomas, but the biological heterogeneity of these tumors has presented a challenge to clinical integration of small molecule inhibitors in sarcoma treatment. Here we outline a  process to personalize therapy for sarcomas through a case study of a canine with spontaneous osteosarcoma. PROCEDURE: Rapid establishment of a primary tumor cell  culture is described, followed by efficient functional characterization of the tumor that identified the Src inhibitor dasatinib as the most effective targeted  therapy for this individual dog. RESULTS: Adjuvant dasatinib was administered for a total of 26 weeks following treatment with chemotherapy. Pharmacokinetic studies confirm that a therapeutic serum concentration was achieved at a tolerable dose of 0.75 mg/kg/day. The canine patient remains without evidence of  recurrent disease 24 months following initial diagnosis. CONCLUSIONS: The approach described through this illustrative case study is broadly applicable and might be used for other solid tumors in canines as well as in humans. Pediatr Blood Cancer 2013;9999:XX-XX. © 2013 Wiley Periodicals, Inc.

 

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[365]

TÍTULO / TITLE:  - Generalized eruptive histiocytoma: a rare disease in an elderly patient*.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - An Bras Dermatol. 2013 Feb;88(1):105-8.

AUTORES / AUTHORS:  - Cardoso F; Serafini NB; Reis BD; Nunez MD; Nery JA; Lupi O

RESUMEN / SUMMARY:  - Generalized eruptive histiocytoma is considered an extremely rare subtype of non-Langerhans cells histiocytosis. In the literature, there are few reports of this disease that mainly affects adults. In this report, we present a case of generalized eruptive histiocytoma in an elderly patient who had presented symptoms for over two months. Multiple erythematous papules, asymptomatic and symmetrically distributed were observed on the trunk and limbs. Histological examination showed a dense mononuclear cell dermal infiltrate. In the immunohistochemical analysis, the cells were CD68 positive, but CD1a, S100 and CD34 negative. A diagnosis of generalized eruptive histiocytoma was established.  The aim of our paper is to report a case of a very rare disease, whose subtype and affected age group are even more unusual.

 

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[366]

TÍTULO / TITLE:  - The Histone Deacetylase Inhibitor, MS-275 (Entinostat), Downregulates c-FLIP, Sensitizes Osteosarcoma Cells to FasL, and Induces the Regression of Osteosarcoma Lung Metastases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Curr Cancer Drug Targets. 2013 Jan 21.

AUTORES / AUTHORS:  - Rao-Bindal K; Koshkina NV; Stewart J; Kleinerman ES

INSTITUCIÓN / INSTITUTION:  - Division of Pediatrics and The Metastasis Research Center, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. ekleiner@mdanderson.org.

RESUMEN / SUMMARY:  - The purpose of this study was to determine the effects of the histone deacetylase inhibitor, MS-275, on the Fas signaling pathway and susceptibility of osteosarcoma (OS) to Fas ligand (FasL)-induced cell death. OS metastasizes almost exclusively to the lungs. We have shown that Fas expression in OS cells is inversely correlated with their metastatic potential. Fas+ cells are rapidly eliminated when they enter the lungs via interaction with FasL, which is constitutively expressed in the lungs. Fas- OS cells escape this FasL-induced apoptosis and survive in the lung microenvironment. Moreover, upregulation of Fas in established OS lung metastases results in tumor regression. Therefore, agents  that upregulate Fas expression or activate the Fas signaling pathway may have therapeutic potential. Treatment of Fas- metastatic OS cell lines with 2 microM MS-275 sensitized cells to FasL-induced cell death in vitro. We found that MS-275 did not alter the expression of Fas on the cell surface; rather it resulted in the downregulation of the anti-apoptotic protein, c-FLIP (cellular FLICE-inhibitory protein), by inhibiting c-FLIP mRNA. Downregulation of c-FLIP correlated with caspase activation and apoptosis induction. Treatment of nu/nu-mice with established OS lung metastases with oral MS-275 resulted in tumor regression, increased apoptosis and a significant inhibition of c-FLIP expression in tumors. Histopathological examination of mice showed no evidence of significant toxicity. Overall, these results suggest that the mechanism by which  MS-275 sensitizes OS cells and lung metastases to FasL-induced cell death may be  by a direct reduction in the expression of c-FLIP.

 

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[367]

TÍTULO / TITLE:  - Molecular Analysis of the KIT Gene in Gastrointestinal Stromal Tumors With Novel  Mutations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Appl Immunohistochem Mol Morphol. 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAI.0b013e318284a074

AUTORES / AUTHORS:  - Calibasi G; Baskin Y; Alyuruk H; Cavas L; Oztop I; Sagol O; Atila K; Ellidokuz H; Yilmaz U

INSTITUCIÓN / INSTITUTION:  - *Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University daggerGraduate School of Natural and Applied Sciences double daggerDepartment of  Chemistry, Division of Biochemistry, Faculty of Science, Kaynaklar Campus Departments of section signMedical Oncology parallelPathology paragraph signSurgery, Faculty of Medicine #Department of Preventive Oncology, Institute of Oncology, Inciralti, Izmir-Turkey.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. KIT gene mutations have great importance for GISTs. This study evaluated the relationship between KIT mutations and GIST clinicopathologic features to define region-specific and population-specific differences. Genomic DNA was extracted from 60 GISTs, and polymerase chain reaction was performed for KIT gene exons 9, 11, 13, and 17. Polymerase chain reaction amplicons were sequenced in both directions. This study represents the first mutation data of the KIT gene in GISTs from a Turkish population and reports novel mutations. The mutation rate in exon 11 (46.7%) was remarkably higher than those of the other exons (8.3% for exon 9; 11.7% for exon 13; 1.7% for exon 17). There was an association between malignancy potential and the presence of KIT mutations (odds ratio=3.18). Cases with mutations in codons W557-K558 in exon 11 had 11-fold greater risk of malignancy when compared with those without a mutation in this exon (odds ratio=11). We report different mutations than those previously reported, which emphasizes the importance of personalized medicine that could be empowered by the use of bioinformatics tools  in the diagnostic process and therapeutic approaches.

 

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[368]

TÍTULO / TITLE:  - Contemporary minimally invasive treatment options for renal angiomyolipomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Curr Urol Rep. 2013 Apr;14(2):147-53. doi: 10.1007/s11934-013-0311-3.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11934-013-0311-3

AUTORES / AUTHORS:  - Sivalingam S; Nakada SY

INSTITUCIÓN / INSTITUTION:  - University of Wisconsin-Madison, Madison, WI, USA.

RESUMEN / SUMMARY:  - Renal angiomyolipomas (AMLs) are benign renal masses that are often asymptomatic  and detected incidentally. However, treatment might be necessary in symptomatic presentations or when the mass exceeds 4 cm in size. While the goal of management for renal AMLs is to relieve symptoms and prevent hemorrhage, a priority is renal function preservation, especially given the propensity of these lesions to recur. The traditional treatment for renal AMLs is renal angioembolization or surgical excision of the lesion. With advancements in minimally invasive surgery, several  other modalities have now emerged for nephron sparing approaches. These include angioembolization, laparoscopic and percutaneous ablative therapies such as radiofrequency ablation, cryoablation and microwave ablation, and pure or robot-assisted laparoscopic partial nephrectomy. Given the relatively low frequency of renal AMLs requiring treatment, much of the available literature on  these minimally invasive approaches is largely extrapolative, based on series on  small renal masses, i.e. renal cell carcinoma (RCC). This report is based on a thorough review of the published literature to date on the minimally invasive treatment and outcomes of renal AMLs.

 

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[369]

TÍTULO / TITLE:  - Differential clinical and pathological characteristics of esophageal stromal tumors and leiomyomata.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dis Esophagus. 2013 Feb 5. doi: 10.1111/dote.12032.

            ●● Enlace al texto completo (gratuito o de pago) 1111/dote.12032

AUTORES / AUTHORS:  - Fei BY; Yang JM; Zhao ZS

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, Zhejiang Provincial People’s Hospital, Hangzhou,  China.

RESUMEN / SUMMARY:  - The objective of the study was to assess the differences in clinical and pathological characteristics between esophageal stromal tumor and leiomyoma. Data from 93 esophageal stromal tumors and leiomyomata cases were retrospectively analyzed, including clinical symptoms, endoscopic features, pathological characteristics, immunohistochemistry (IHC), and treatment. All cases underwent endoscopic ultrasonography examination before treatment. Lesions arising from the muscularis mucosa were resected by endoscopic mucosal resection or endoscopic submucosal dissection. Lesions arising from the muscularis propria were resected  by surgery. All specimens were examined by IHC. Patients were followed up after endoscopic mucosal resection or endoscopic submucosal dissection. No difference was observed in clinical symptoms and endoscopic features between the two groups. Endoscopic ultrasonography demonstrated all lesions to be hypoechoic and well circumscribed. Most lesions >2 cm had heterogeneous internal ultrasound signal. In esophageal stromal tumor, 100% (29/29) were CD117-positive and DOG-1-positive; 72.4% (21/29) and 51.7% (15/29) were CD34-positive and smooth muscle actin-positive, respectively. In esophageal leiomyomata, 100% (64/64) were smooth muscle actin-positive and desmin-positive; 100% were CD117-negative and DOG-1-negative. No local recurrence was detected in followed up patients (n = 49) after an average of 1.8 years (1.0-3.0 years). IHC analyses are important for distinguishing esophageal stromal tumor from leiomyoma. Early endoscopic resection is an effective treatment option for esophageal stromal tumors >1 cm.

 

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[370]

TÍTULO / TITLE:  - Pazopanib , a new therapy for metastatic soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Expert Opin Pharmacother. 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1517/14656566.2013.780030

AUTORES / AUTHORS:  - Verweij J; Sleijfer S

INSTITUCIÓN / INSTITUTION:  - Erasmus MC Cancer Institute, Department of Medical Oncology , ‘ s-Gravendijkwal 230, Room He-116, 3015 CE Rotterdam , The Netherlands j.verweij@erasmusmc.nl.

RESUMEN / SUMMARY:  - Introduction: Pazopanib (GW786034, Votrient®) is a vascular endothelial growth  factor receptor-focused multi-tyrosine kinase inhibitor involved in inhibiting the angiogenesis pathway. The agent was recently registered for use in soft tissue sarcomas, a group of diseases with a major unmet medical need. Areas covered: The relevance of angiogenesis in soft tissue sarcomas is discussed. These data were the basis to decide on the development of pazopanib in these diseases. The clinical pharmacology of pazopanib, as far as practically relevant, is summarized. After the first observations of possible activity in soft tissue sarcomas in the Phase I study, a Phase II and subsequent randomized placebo-controlled Phase III study were performed and are being put into perspective in this review. Expert opinion: Pazopanib is an active drug for the treatment of chemotherapy-failing nonadipocytic soft tissue sarcomas. It almost triples progression-free survival significantly from 1.6 to 4.6 months in this heavily pretreated population. The safety profile is manageable, exemplified by the high dose intensity that can be achieved over time. Pazopanib can be considered as part of the standard of care for patients with soft tissue sarcomas.

 

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[371]

TÍTULO / TITLE:  - The evolution of systemic therapy in sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Expert Rev Anticancer Ther. 2013 Feb;13(2):211-23. doi: 10.1586/era.12.161.

            ●● Enlace al texto completo (gratuito o de pago) 1586/era.12.161

AUTORES / AUTHORS:  - Constantinidou A; Pollack S; Loggers E; Rodler E; Jones RL

INSTITUCIÓN / INSTITUTION:  - The Royal Marsden Hospital, London, UK.

RESUMEN / SUMMARY:  - Approximately 50% of patients with localized soft tissue sarcomas will develop recurrent disease after complete surgical resection, requiring alternative means  of treatment. Conventional chemotherapy comprising of doxorubicin and ifosfamide  has shown benefit in advanced disease, however, there remains a clear need for more effective, less toxic, therapies for the treatment of this heterogeneous group of mesenchymal malignancies. Recently, greater emphasis has been placed on  the underlying biology of individual sarcoma subtypes, with the development and evaluation of novel therapies both in common and in rare subtypes. In addition, there is a greater specificity in the selection of chemotherapy agents based on activity in individual histological subtypes. Despite these advances the management of sarcoma, and in particular of rare subtypes, remains a major challenge. Some histological subtypes are resistant to conventional chemotherapy  and patients with these diseases should be offered participation in early phase clinical trials of novel drugs.

 

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[372]

TÍTULO / TITLE:  - Gastrointestinal stromal tumors and its frequency in our clinical samples.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Arh. 2012;66(6):369-71.

AUTORES / AUTHORS:  - Vukobrat-Bijedic Z; Husic-Selimovic A; Bijedic N; Saray A; Djuran A; Gogov B; Bjelogrlic I

INSTITUCIÓN / INSTITUTION:  - Clinical Center of University of Sarajevo, Bolnicka 25, Sarajevo, Bosnia and Herzegovina.

RESUMEN / SUMMARY:  - BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. The majority of GISTs are located in the stomach. Only 3-5% of GISTs are located in the duodenum associated with an increased risk of gastrointestinal bleeding as primary manifestation. AIM: The aim of our study was to present frequencies of GIST in patients who underwent endoscopic procedures at Gastroenterohepatology Department due to different reasons. We also investigated the most frequent localization of GIST tumors and pathohistologicall pattern of tissue samples. PATIENTS AND METHODS: Twenty two patients examined at gastroenterology department were analyzed in the period from 2005 until 2012. All of the patients were endoscopically examined ( gastroscopy,  colonoscopy, endoscopic ultrasound). A few patients were referred from surgery where GIST was diagnosed during surgical procedure. Macroscopically noticed changes were pathohistologically analyzed by immunohistochemical staining (Alpha-smooth muscle actin (SMA), CD34, CD117, Ki-67 antigen, cytokeratin i desmin). RESULTS: No significant difference in gender distribution of patients with GIST-s was found. We also analyzed the appearance of GIST with respect to mean patient age and no statistically significant difference was found either. However, investigation of tumor localization related to gender of patients we found a difference in gender distribution of tumor localization. In female GIST-s are more often located in the stomach than in men, with a significance level of 0.05. Immunohistochemical analysis of biopsy samples showed that CD 117 is statistically significant more frequent in men than in woman. CONCLUSION: Taking  in account the small sample size in our investigation over a period of seven years, we are not able to give a definitive conclusion about GIST. Further studies and observations are necessary to give a definite conclusion.

 

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[373]

TÍTULO / TITLE:  - Calcified brain metastases from osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Can J Neurol Sci. 2013 Mar;40(2):247-8.

AUTORES / AUTHORS:  - De Pablo-Fernandez E; Gomez-Herrera JJ; Sierra-Hidalgo F; Sanchez-Ferro A

INSTITUCIÓN / INSTITUTION:  - Neurology Department, King’s College Hospital, Denmark Hill, London, United Kingdom.

 

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[374]

TÍTULO / TITLE:  - A case of congenital myofibroma of the orbit presenting at birth.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orbit. 2013 Feb;32(1):33-5. doi: 10.3109/01676830.2012.736594.

            ●● Enlace al texto completo (gratuito o de pago) 3109/01676830.2012.736594

AUTORES / AUTHORS:  - Bloom RI; Schwarcz RM; Zhang C; Rosenberg JB

INSTITUCIÓN / INSTITUTION:  - Department of Ophthalmology and Visual Sciences, Montefiore Medical Center, Bronx, NY, USA. rachelbloommd@gmail.com

RESUMEN / SUMMARY:  - PURPOSE: The purpose of this report is to highlight a rare cause of congenital proptosis. METHODS: This is a case report. RESULTS: We present a case of a baby girl born with a large myofibroma in the right retrobulbar space. This case is unusual because it presented from birth and was in a critical location. A prenatal ultrasound performed two days prior to birth did not reveal this mass to the technician or obstetrician. At birth, the tumor induced severe proptosis, with the eyelids unable to close around the globe. Deterioration of the ocular surface secondary to exposure was evident immediately after birth. One week after birth, the mass was excised by the Oculoplastics service in conjunction with a Neurosurgical team using a transcranial approach. The tumor was diagnosed by histopathology and immunologic staining as a myofibroma, a rare condition. CONCLUSIONS: Orbital myofibroma is a rare cause of congenital proptosis presenting at birth.

 

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[375]

TÍTULO / TITLE:  - Two cases of right atrial myxoma in redo patients. A mere coincidence?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - G Chir. 2013 Jan;34(1-2):11-3.

AUTORES / AUTHORS:  - Sansone F; Ceresa F; Patane F

RESUMEN / SUMMARY:  - We describe two cases of right atrial myxoma in redo patients who had previously  undergone to coronary artery by-pass grafting (CABGs) and mitral valve replacement respectively. Both of patients experienced effort dyspnea and were assessed by trans-thoracic echocardiography, revealing the right atrial masses. They were operated on for myxoma resection and postoperative course was uneventful. Our report deals with the interesting topic of the location of benign masses that are usually more common in the left atrium. Should we hypothesize that the right atrial manipulation during the previous surgery induces the onset  of the right atrial mass? It is an interesting matter to debate.

 

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[376]

TÍTULO / TITLE:  - Lesson of the month. (2). Stroke in a 53-year-old woman: getting to the heart of  the problem. Diagnosis. LA myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Med. 2013 Feb;13(1):106-9.

AUTORES / AUTHORS:  - Pearce AW; Rana BS; O’Donovan DG

INSTITUCIÓN / INSTITUTION:  - Papworth Hospital NHS Foundation Trust, Cambridge. alex.pearce@papworth.nhs.uk

 

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[377]

TÍTULO / TITLE:  - A large soft tissue mass of the chest wall.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neth J Med. 2013 Mar;71(2):86-89.

AUTORES / AUTHORS:  - Beenen LF; Koolen MK; Hoogerwerf JJ; Schep NW

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Academic Medical Centre, Amsterdam, the Netherlands.

RESUMEN / SUMMARY:  - No abstract available.

 

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[378]

TÍTULO / TITLE:  - Oral soft-tissue angiolipoma: report of two cases of rare oral lipomatous lesion  with emphasis on morphological and immunohistochemical features.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Sci. 2013;55(1):85-8.

AUTORES / AUTHORS:  - O Silva-Junior G; L Picciani B; C Costa R; M Barbosa S; G Silvares M; B Souza R; H Cantisano M; R Pires F

INSTITUCIÓN / INSTITUTION:  - Department of Stomatology, School of Dentistry, State University of Rio de Janeiro.

RESUMEN / SUMMARY:  - Oral angiolipomas are exceedingly rare and little is known about their morphological and etiological features. Here, we report two cases of oral angiolipoma and discuss their clinicopathological and immunohistochemical features, focusing on endothelial markers. Both lesions presented mature adipocytes interspersed by small blood vessels containing fibrin thrombi. Immunohistochemical analysis showed numerous mast cells and expression of CD34, vascular endothelial growth factor, intercellular adhesion molecule-1, interferon-gamma and interleukin 6 in most endothelial and stromal cells. Mast cell-endothelial cell interaction may be responsible for the reactive or neoplastic origin of the vascular proliferation of these entities. (J Oral Sci 55, 85-88, 2013).

 

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[379]

TÍTULO / TITLE:  - A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Expert Opin Ther Targets. 2013 Feb 25.

            ●● Enlace al texto completo (gratuito o de pago) 1517/14728222.2013.772136

AUTORES / AUTHORS:  - Olanich ME; Barr FG

INSTITUCIÓN / INSTITUTION:  - National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Pathology , Bethesda, MD 20892 , USA +1 301 594 3780 ; +1 301 480 0853 ; barrfg@mail.nih.gov.

RESUMEN / SUMMARY:  - Introduction: Expression of fusion oncoproteins generated by recurrent chromosomal translocations represents a major tumorigenic mechanism characteristic of multiple cancers, including one-third of all sarcomas. Oncogenic fusion genes provide novel targets for therapeutic intervention. The PAX3-FOXO1 oncoprotein in alveolar rhabdomyosarcoma (ARMS) is presented as a paradigm to examine therapeutic strategies for targeting sarcoma-associated fusion genes. Areas covered: This review discusses the role of PAX3-FOXO1 in ARMS tumors. Besides evaluating various approaches to molecularly target PAX3-FOXO1 itself, this review highlights therapeutically attractive downstream genes activated by PAX3-FOXO1. Expert opinion: Oncogenic fusion proteins represent desirable therapeutic targets because their expression is specific to tumor cells, but these fusions generally characterize rare malignancies. Full development and testing of potential drugs targeted to these fusions are complicated by the small numbers of patients in these disease categories. Although efforts to develop targeted therapies against fusion proteins should continue, molecular targets that are applicable to a broader tumor landscape should be pursued. A shift of the traditional paradigm to view therapeutic intervention as target-specific rather than tumor-specific will help to circumvent the challenges posed by rare tumors and maximize the possibility of developing successful new treatments for patients with these rare translocation-associated sarcomas.

 

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[380]

TÍTULO / TITLE:  - Multiple primary malignancies in elderly patients with high-grade soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Clin Oncol. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10147-013-0543-8

AUTORES / AUTHORS:  - Kozawa E; Sugiura H; Tsukushi S; Urakawa H; Arai E; Futamura N; Nakashima H; Yamada Y; Ishiguro N; Nishida Y

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan.

RESUMEN / SUMMARY:  - BACKGROUND: Several previous reports have described multiple cancers with regard  to epithelial tumors, but few reports have focused on multiple primary malignancies including soft tissue sarcomas (STS). METHODS: The purpose of this study was to analyze the clinical features of patients with high-grade STS with multiple malignancies and possible clinical problems, compared with those with STS as a single malignancy, focusing on elderly patients. This study enrolled 107 patients aged 65 years or over with high-grade STS. RESULTS: Eighty-four patients (79 %) had sarcomas only (S group), and 23 (21 %) had multiple primary malignancies (M group). STS preceded carcinoma in 10 patients, and carcinoma preceded STS in 13. In 7 patients (30 %), the interval between the first and second malignancy was less than a year. Of 7 patients who received treatment for  sarcoma and carcinoma at the same time, the presence of other malignancies had an impact on determination of the treatment modality in 5 patients. The overall survival rate at 5 years was higher in M group (79 %) than in S group (69 %), although this difference was not significant (P = 0.095). CONCLUSIONS: This study demonstrates that the presence of multiple malignancies was not correlated with a poor prognosis, and was actually associated with a better prognosis in elderly patients with STS. Physicians should be aware of the possible occurrence of a second malignancy, and on occasion the treatment modalities and their logistical  aspects need to be well organized and carefully selected for patients with ongoing multiple malignancies.

 

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[381]

TÍTULO / TITLE:  - Atypical Fibroxanthoma of the Medial Canthus: A Rare Presentation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orbit. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 3109/01676830.2013.771680

AUTORES / AUTHORS:  - Rathore D; Mohyudin MN; Mehta P; Ahluwalia HS

INSTITUCIÓN / INSTITUTION:  - University Hospitals of Coventry and Warwickshire, Ophthalmology , Coventry , UK.

RESUMEN / SUMMARY:  - ABSTRACT Purpose: Atypical fibroxanthoma (AFX) is an uncommon skin tumour occurring primarily in the head and neck. It has rarely been reported in the periocular region. We report a rare case of atypical fibroxanthoma of the medial  canthus. Methods: Clinical and histological findings and management of this case  are presented.Results: A 90-year-old Caucasian female had primary excision of a medial canthal mass, which was clinically suspected as basal cell carcinoma by our Plastic surgery colleagues. Histology revealed an atypical fibroxanthoma with incomplete excision, with the tumour involving the deep and peripheral resection  margins. Within a few weeks she developed a recurrent mass, which was clinically  fixed to deep tissues. She was referred to the Oculoplastic service where she underwent a two-stage excision and reconstruction of the right medial canthus with a full thickness skin graft from her arm. Paraffin fixed sections were used  to ensure margin clearance. Conclusion: This case emphasises the importance of a  diagnostic biopsy. A panel of immunohistochemical markers is essential to make the correct diagnosis of AFX and distinguish it from malignant fibrohistiocytoma  and non-keratin expressing squamous cell carcinoma. It usually follows a benign course, but can occasionally demonstrate aggressive local recurrence as well as distant metastasis. Invasion beyond the dermis and a rapid rate of recurrence are suggestive of a more aggressive clinical course. Paraffin fixed sections are preferred over frozen section techniques for this tumour. Medial canthal AFX has  not been reported previously.

 

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[382]

TÍTULO / TITLE:  - Primary Dermatofibrosarcoma Protuberans of Orbit-A Rare Entity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orbit. 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 3109/01676830.2013.764450

AUTORES / AUTHORS:  - Rahman T; Bhattacharjee K; Sarma JD; Dey D; Kuri G

INSTITUCIÓN / INSTITUTION:  - Dr. B. Borooah Cancer Institute, Regional Cancer Centre, Assistant Professor, Department of Head and Neck Oncology , Assam, Guwahati , India , and.

RESUMEN / SUMMARY:  - Abstract Primary Dermatofibrosarcoma Protuberance (DFSP) is a rare neoplasm of dermal origin. Though it is a locally aggressive tumor with high recurrence rate, however distant metastasis can also occur. Orbital DFSP is an uncommon phenomenon. It has been reported due to distant metastasis or invasion from adjacent structures but Primary Orbital DFSP is a unique entity in itself. Herein we report a rare case of primary DFSP of the orbit in a 70-year- old lady who underwent orbital exenteration. Histopathology examination (HPE) revealed spindle cells arranged in storiform pattern and immunohistochemistry (IHC) revealed CD34  positive and S100 negative.

 

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[383]

TÍTULO / TITLE:  - Isolated Diffuse Episcleral Neurofibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orbit. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 3109/01676830.2013.764447

AUTORES / AUTHORS:  - Mohyudin MN; Darrad M; Murray A; Thaung C

INSTITUCIÓN / INSTITUTION:  - Department of Ophthalmology, Birmingham Midlands Eye Centre , Birmingham , United Kingdom , and.

RESUMEN / SUMMARY:  - Abstract Aims: To report a rare case of isolated diffuse episcleral neurofibroma  and to discuss possible differential diagnoses. Case report: A 37 year old Caucasian female was found to have an epibulbar tumour arising from the superior  aspect of her left eye. Clinical examination revealed a 12 mm x 8 mm “salmon pink” coloured lesion. Results: A biopsy was performed and histopathologic examination and subsequent systemic evaluation showed it to be a rare case of isolated diffuse episcleral neurofibroma. Conclusion: There are many differential diagnoses for an epibulbar lesion and neurofibroma should be added to these. Even though a small risk of malignant transformation exists, we recommend a conservative approach for slow growing lesions.

 

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[384]

TÍTULO / TITLE:  - Dermatofibrosarcoma Protuberans with Primary Orbital Manifestation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orbit. 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 3109/01676830.2012.758748

AUTORES / AUTHORS:  - Schittkowski MP; Wrede A

INSTITUCIÓN / INSTITUTION:  - University Eye Department and.

RESUMEN / SUMMARY:  - Abstract A 45-year-old, otherwise healthy woman presented with mild epiphora and  a palpable mass in the lacrimal sac area. After transcutaneus orbitotomy and complete excision histopathology revealed a primary Dermatofibrosarcoma protuberans invading the orbit. During the 24-months follow-up, no recurrence occurred. To the best of our knowledge this is the first report of a primary DFSP with the orbit involved.

 

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[385]

TÍTULO / TITLE:  - A rare case of massive carpal osteoblastoma requiring complex reconstructive surgery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Plast Reconstr Aesthet Surg. 2013 Mar 10. pii: S1748-6815(13)00110-1. doi: 10.1016/j.bjps.2013.02.026.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bjps.2013.02.026

AUTORES / AUTHORS:  - Dunda SE; Kauczok J; Demir E; Braunschweig T; Pallua N

INSTITUCIÓN / INSTITUTION:  - Department of Plastic Surgery, Reconstructive and Hand Surgery, Burn Center, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. Electronic address: sdunda@ukaachen.de.

RESUMEN / SUMMARY:  - An osteoblastoma is a rare, commonly benign, osteoid-producing neoplasm of the bone with an incidence of 2% of all primary bone tumours. We present a case of a  54-year-old patient with persisting carpal pain and massive swelling of the hand  for a period of 4 years. Incision biopsies revealed the histopathological finding of a carpal osteoblastoma. After complete tumour excision, including the carpal and, in parts, metacarpal bones, reconstructive surgery was performed with a free osteocutaneous iliac crest flap to obtain a natural hand contour and the best possible hand function. Follow-up revealed improvement of the hand function in terms of flexion, extension and strength without discomfort or further pain. Thus, ongoing carpal pain should lead to an intensive search with further diagnostic measures such as magnetic resonance imaging (MRI) scan as well as biopsies, if necessary, to obtain the correct diagnosis.

 

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[386]

TÍTULO / TITLE:  - Early tendon transfer after wide resection of an undifferentiated sarcoma of the  forearm in a neonate: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Plast Reconstr Aesthet Surg. 2013 Feb 6. pii: S1748-6815(13)00009-0. doi: 10.1016/j.bjps.2013.01.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bjps.2013.01.002

AUTORES / AUTHORS:  - van Bommel A; Aslam R; Brundler MA; Hobin D; Jester A

INSTITUCIÓN / INSTITUTION:  - Department of Plastic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address: acmvanbommel@gmail.com.

RESUMEN / SUMMARY:  - A 1-month-old female baby was diagnosed with an undifferentiated sarcoma of her forearm after incisional biopsy. She received five cycles of chemotherapy before  a wide resection of her extensor muscles including the radial nerve was undertaken, resulting in a complete drop of wrist and fingers. At this stage, primary tendon transfer of the brachioradialis to extensor carpi radial brevis muscle was performed, which proved to be not sufficient. Five months after resection of the tumour, restoration of the extensor function was achieved by flexor tendon transfers to provide wrist, finger and thumb extension. After 2 years, the patient did not show any signs of recurrence and she has a good wrist, finger and thumb extension and flexion. The diagnosis of an undifferentiated sarcoma is one per exclusion. Treatment includes chemotherapy and complete resection of the tumour with a wide margin. We discuss the diagnosis of undifferentiated sarcoma as well as early restoration of hand function in neonates.

 

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[387]

TÍTULO / TITLE:  - Echocardiographic Study of Intravenous Leiomyomatosis with Intracardiac Extension: Two Case Reports and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Heart Lung Circ. 2013 Feb 3. pii: S1443-9506(12)01394-7. doi: 10.1016/j.hlc.2012.11.018.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.hlc.2012.11.018

AUTORES / AUTHORS:  - Li RJ; Zhang CC; Yang Y; Song L; Wang Z; Luo XH; Su RJ

INSTITUCIÓN / INSTITUTION:  - Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

 

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[388]

TÍTULO / TITLE:  - Leiomyomatosis peritonealis disseminata and pregnancy: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Exp Obstet Gynecol. 2012;39(4):541-3.

AUTORES / AUTHORS:  - Kouakou F; Adjoby R; Gondo D; Loue V; N’Guessan K; Kouame A; Effoh D

INSTITUCIÓN / INSTITUTION:  - Department of Gynecology and Obstetrics of the University Hospital of Cocody, Mother-Child Department, Faculty of Medical Sciences University of Cocody, Abidjan, Cote d’Ivoire. drlouevedi@yahoo.fr

RESUMEN / SUMMARY:  - Leimyomatosis peritonealis disseminata (LPD) is a benign tumor of smooth muscle tissue. It is rare and is characterized by the development of multiple peritoneal nodules mimicking peritoneal carcinomatosis. We report a case of LPD diagnosed in a 35-year-old patient, G4/P1, without any major gynecological history. The patient underwent an elective cesarean section at 42 weeks, during which numerous peritoneal nodules ranging in size from 0.1 to 0.5 cm were found. Microscopic examination showed a proliferation of smooth-muscle cells without mitosis or atypia or necrosis.

 

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[389]

TÍTULO / TITLE:  - Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Transl Med. 2013 Feb 21;11:46. doi: 10.1186/1479-5876-11-46.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1479-5876-11-46

AUTORES / AUTHORS:  - Katz SC; Burga RA; Naheed S; Licata LA; Thorn M; Osgood D; Nguyen CT; Espat NJ; Fletcher JA; Junghans RP

INSTITUCIÓN / INSTITUTION:  - Roger Williams Medical Center, Department of Surgery, Providence, RI/Boston University School of Medicine, Boston, MA, USA. skatz@chartercare.org.

RESUMEN / SUMMARY:  - BACKGROUND: Imatinib mesylate is an effective treatment for metastatic gastrointestinal stromal tumor (GIST). However, most patients eventually develop  resistance and there are few other treatment options. Immunotherapy using genetically modified or designer T cells (dTc) has gained increased attention for several malignancies in recent years. The aims of this study were to develop and  test novel anti-KIT dTc engineered to target GIST cells. METHODS: Human anti-KIT  dTc were created by retroviral transduction with novel chimeric immune receptors  (CIR). The gene for stem cell factor (SCF), the natural ligand for KIT, was cloned into 1st generation (SCF-CD3zeta, 1st gen) and 2nd generation (SCF-CD28-CD3zeta, 2nd gen) CIR constructs. In vitro dTc proliferation and tumoricidal capacity in the presence of KIT+ tumor cells were measured. In vivo assessment of dTc anti-tumor efficacy was performed by treating immunodeficient mice harboring subcutaneous GIST xenografts with dTc tail vein infusions. RESULTS: We successfully produced the 1st and 2nd gen anti-KIT CIR and transduced murine and human T cells. Average transduction efficiencies for human 1st and 2nd gen dTc were 50% and 42%. When co-cultured with KIT+ tumor cells, both 1st and 2nd gen dTc proliferated and produced IFNgamma. Human anti-KIT dTc were efficient at lysing GIST in vitro compared to untransduced T cells. In mice with established GIST xenografts, treatment with either 1st or 2nd gen human anti-KIT  dTc led to significant reductions in tumor growth rates. CONCLUSIONS: We have constructed a novel anti-KIT CIR for production of dTc that possess specific activity against KIT+ GIST in vitro and in vivo. Further studies are warranted to evaluate the therapeutic potential and safety of anti-KIT dTc.

 

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[390]

TÍTULO / TITLE:  - Red flags and alarm bells: an atypical lesion masquerading as a diabetic foot ulcer.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Wound Care. 2012 Nov;21(11):550, 552.

AUTORES / AUTHORS:  - Koo E; Walsh A; Dickson H

INSTITUCIÓN / INSTITUTION:  - Department of Podiatry, High Risk Foot Service, Liverpool Hospital, Liverpool, Australia. erika.koo@sswahs.nsw.gov.au

RESUMEN / SUMMARY:  - An 88-year-old male presented at a high-risk foot service with a non-healing, plantar wound on his right foot, which had the appearance of a neuropathic ulcer. On further examination, the lesion was confirmed asymmetrical in shape and atypical in appearance. It also presented with surrounding violaceous, pigmented  nodules in the arch of the foot, and several small, similar nodules on the plantar surface of the contralateral foot, giving the appearance of an exophytic  lesion and suggesting melanoma. Following biopsy, it was diagnosed as classic Kaposi sarcoma.

 

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[391]

TÍTULO / TITLE:  - Functional outcome following upper limb soft tissue sarcoma resection with flap reconstruction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Plast Reconstr Aesthet Surg. 2013 May;66(5):601-7. doi: 10.1016/j.bjps.2013.01.034. Epub 2013 Feb 21.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bjps.2013.01.034

AUTORES / AUTHORS:  - Payne CE; Hofer SO; Zhong T; Griffin AC; Ferguson PC; Wunder JS

INSTITUCIÓN / INSTITUTION:  - Division of Plastic Surgery, University Health Network, University of Toronto, Toronto, Canada.

RESUMEN / SUMMARY:  - BACKGROUND: Upper limb preservation after soft tissue sarcoma resection often requires flap reconstruction. The aim of this study was to compare pre- and post-operative upper limb function following shoulder, elbow or wrist/hand sarcoma resection and soft tissue reconstruction with a pedicled or free flap. PATIENTS: Between 1989 and 2008, 113 patients underwent resection of an upper limb soft tissue sarcoma and required flap reconstruction. Perioperative morbidity, mortality and flap loss were studied. Functional outcome was assessed  pre and postoperatively using the Toronto Extremity Salvage Score (TESS), a measure of disability, and the Musculoskeletal Tumour Society Rating Scale (MSTS), a measure of impairment. Statistical analyses were performed to evaluate  the relationship between flap type and functional outcome scores. RESULTS: Patients underwent soft tissue sarcoma excision in the shoulder (n = 64), elbow (n = 27) or wrist/hand (n = 22) region with soft tissue reconstruction using either a pedicled (n = 76) or free flap (n = 37). Comparison of the post-operative MSTS (n = 88) and TESS (n = 84) revealed no significant differences between the free and pedicled flap groups. A significant pre- to post-operative difference was identified in MSTS 87 scores for patients in both the pedicled (p < 0.02) and free flap groups (p < 0.04). Comparison of the pre- and post-operative MSTS 93 scores also revealed a significant difference (p < 0.01) but this was limited to the free flap group. The most notable post-operative score reductions in these patients were due to major joint, nerve, tendon or muscle group resection. CONCLUSION: Reconstruction of the soft tissue defect following sarcoma resection in the upper limb maintains a similar satisfactory level of upper limb activity with either pedicled or free flap reconstructions. Based on TESS scores, patients rated themselves as having better function compared to impairment measures such as MSTS.

 

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[392]

TÍTULO / TITLE:  - An ectopic tooth concealing an odontogenic myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dent Update. 2013 Jan-Feb;40(1):32-5.

AUTORES / AUTHORS:  - Singh P; Davies HT

INSTITUCIÓN / INSTITUTION:  - Chelsea and Westminster Hospital, UK.

RESUMEN / SUMMARY:  - This case report presents a 13-year-old girl who attended an orthodontic clinic for an ectopic UR5. After investigation, a diagnosis of an odontogenic myxoma was made and the tumour was excised. A panoramic radiograph taken almost two years earlier for another dental problem was found to show an ectopic UR5 associated with a subtle radiolucency. Odontogenic myxomas may be of higher frequency than once thought in the paediatric population and therefore should always be considered in the differential diagnosis of any intraosseous radiolucency. Any radiolucent area associated with an unerupted tooth should be investigated further or closely followed up. Clinical Relevance: The odontogenic myxoma is a rare but potentially serious benign tumour of the jaws.

 

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[393]

TÍTULO / TITLE:  - Parasitic leiomyoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mymensingh Med J. 2013 Jan;22(1):173-5.

AUTORES / AUTHORS:  - Jebunnaher S; Begum SA

INSTITUCIÓN / INSTITUTION:  - Dr Sultana Jebunnaher, Assistant Professor, Obstetrics & Gynecology, Bangladesh Medical College, Dhanmondi, Dhaka, Bangladesh; E-mail: dr.trishna@yahoo.com.

RESUMEN / SUMMARY:  - To report a case of parasitic myomas and examine associations and risk factors, a 35 years old lady presented with a lump in the lower abdomen in Bangladesh Medical College Hospital, Dhaka. Retrospective review was performed based on indications for surgery; types of prior surgeries; prior use of morcellation; and locations of parasitic myomas. Pathologic confirmation of specimen was obtained.  Surgery performed by laparotomy. Myoma was found occupying the pelvis and upper abdomen. Parasitic myomas may occur spontaneously as pedunculated subserosal myomas lose their uterine blood supply and parasitize to other organs. More parasitic myomas may be iatrogenically created after surgery, particularly surgery using morcellation techniques. With increasing rates of laparoscopic procedures, surgeons should be aware of the potential for iatrogenic parasitic myoma formation, their likely increasing frequency, and intraoperative precautions should be taken to minimize occurrence of the type of myoma.

 

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[394]

TÍTULO / TITLE:  - Rare case of gastrointestinal stromal tumour from Meckel’s diverticulum.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - ANZ J Surg. 2013 Mar;83(3):184-5. doi: 10.1111/ans.12061.

            ●● Enlace al texto completo (gratuito o de pago) 1111/ans.12061

AUTORES / AUTHORS:  - Koppad SN; Sonawane SR; Kapoor VB; Deshmukh AM; Borole KA

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, Rural Medical College, Loni, Maharashtra, India.

 

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[395]

TÍTULO / TITLE:  - Congenital peripheral developing odontoma accompanied by congenital teratomatous  fibroma in a 9-month-old boy: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Sci. 2013;55(1):89-91.

AUTORES / AUTHORS:  - Mikami T; Yagi M; Mizuki H; Takeda Y

INSTITUCIÓN / INSTITUTION:  - Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University.

RESUMEN / SUMMARY:  - Peripheral odontoma is rare, and only two cases of congenital peripheral odontoma have been reported. Congenital oral fibroma is also rare. We describe a unique case of congenital peripheral developing odontoma accompanied by congenital teratomatous fibroma in an infant. Both tumors were difficult to detect on radiography. Two small masses were seen in the median anterior portion of the palatal mucosa of a 9-month-old boy. The masses had been present since birth and  were surgically removed at age 28 months, when one of the masses had grown to a diameter of 8 mm. Histopathologic examination showed a fibrous lesion and a tooth germ-like rounded lesion composed of dental papilla, enamel organ, dentin, and cementum. Although congenital odontoma is rare, it should be considered when selecting appropriate treatment, as early radiographic detection is difficult. (J Oral Sci 55, 89-91, 2013).

 

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[396]

TÍTULO / TITLE:  - Intraosseous Lipoma of the Calcaneus: Report of a Case and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Foot Ankle Surg. 2013 Mar 1. pii: S1067-2516(12)00586-8. doi: 10.1053/j.jfas.2012.12.019.

            ●● Enlace al texto completo (gratuito o de pago) 1053/j.jfas.2012.12.019

AUTORES / AUTHORS:  - Aumar DK; Dadjo YB; Chagar B

INSTITUCIÓN / INSTITUTION:  - Orthopedist, Department of Traumatology and Orthopaedics, Military Teaching Hospital Mohamed V, Rabat, Morocco. Electronic address: dakaumar@yahoo.fr.

RESUMEN / SUMMARY:  - Intraosseous lipoma is a rare, benign primary tumor occurring in bone. In the present report, a case of an intraosseous lipoma of the calcaneus is presented, together with a focused review of published studies. Radiographically, the lesions will appear osteolytic and well delineated, displaying a central area of  calcification. Curettage and packing with autogenous bone grafts was our treatment for this rare tumor. In the present case, and 1 previously published case, a central sclerotic mass was observed. The histologic findings were typical, with mature adipose tissue mixed with a few degenerated bone trabeculae.

 

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[397]

TÍTULO / TITLE:  - Do we still need chemotherapy for AIDS-associated Kaposi’s sarcoma?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Expert Rev Anticancer Ther. 2013 Feb;13(2):203-9. doi: 10.1586/era.12.179.

            ●● Enlace al texto completo (gratuito o de pago) 1586/era.12.179

AUTORES / AUTHORS:  - Dalla Pria A; Hayward K; Bower M

INSTITUCIÓN / INSTITUTION:  - National Centre for HIV Malignancy, Chelsea & Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

RESUMEN / SUMMARY:  - The widespread introduction of effective combination antiretroviral therapy (cART) has had a major influence on the epidemiology and natural history of AIDS-associated Kaposi’s sarcoma (AIDS-KS). cART has reduced the incidence of AIDS-KS, and it has been shown to be an effective treatment for early-stage KS. So with the widespread availability of cART, is systemic chemotherapy still required for AIDS-KS? Two indications appear to remain: advanced-stage AIDS-KS and patients who have progressive KS despite effective cART including immune reconstitution inflammatory syndrome KS.

 

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[398]

TÍTULO / TITLE:  - Rhabdomyosarcomatous differentiation in gastrointestinal stromal tumors after imatinib resistance: a potential diagnostic pitfall.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Biol Med (Maywood). 2013 Jan 1;238(1):120-4. doi: 10.1258/ebm.2012.012173.

            ●● Enlace al texto completo (gratuito o de pago) 1258/ebm.2012.012173

AUTORES / AUTHORS:  - Zheng S; Huang KE; Jia J; Li X; Tao DY

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, Hangzhou First People’s Hospital of Zhejiang Province, Hangzhou Cancer Hospital, Hangzhou, 310006.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of  the digestive tract and characterized by expression of protein-tyrosine kinase (KIT) protein. Treatment of advanced GISTs has been improved dramatically following the development of imatinib. Despite the often long-lasting clinical benefit seen in most patients treated with imatinib, many will eventually suffer  disease progression. In general, progressing GISTs retain their typical morphology. In this study, we present a patient with metastatic GISTs, who received more than 16 months of treatment with imatinib and whose tumors changed  their morphological and immunohistochemical characteristics after imatinib-resistance. Histological, immunohistochemical and mutational analysis was performed on the prior and post-imatinib treatment GIST samples. The imatinib-resistant tumor cells in the progressing metastases showed marked pleomorphism which proved to be rhabdomyoblastic differentiation with Desmin and  Myogenin immunopositivity. However, there was no secondary mutation of KIT, PDGFRA, KRAS and BRAF genes found in the imatinib-resistant lesion, except primary KIT V559D mutation. To our knowledge, this case represents the few reports on this unusual type of transdifferentiation in GISTs under imatinib therapy. Awareness of this phenomenon would help to avoid diagnostic confusion when evaluating post-imatinib samples from GISTs.

 

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[399]

TÍTULO / TITLE:  - Radiation-induced angiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dermatol Online J. 2013 Jan 15;19(1):2.

AUTORES / AUTHORS:  - Anzalone CL; Cohen PR; Diwan AH; Prieto VG

INSTITUCIÓN / INSTITUTION:  - Medical School, University of Texas at Houston School of Medicine, Houston, TX, USA.

RESUMEN / SUMMARY:  - BACKGROUND: Radiation-induced angiosarcomas are uncommon adverse sequelae related to treatment of tumors. Early diagnosis and treatment are key to successful management. PURPOSE: The purpose of this case study is to describe the clinical characteristics of radiation-induced angiosarcomas. MATERIALS AND METHODS: We retrospectively reviewed the medical literature using PubMed, searching the terms angiosarcoma, breast, post, radiation, and treatment. Patient reports and previous reviews of the subject were critically assessed and the salient features are presented. RESULTS: Approximately one hundred patients have been diagnosed with radiation-induced angiosarcomas. The condition presents within the radiation field, approximately six years after initial treatment. We describe the dramatic  efficacious response of our patient’s angiosarcoma to adjuvant chemotherapy both  preoperatively (gemcitabine and docetaxel) and postoperatively (gemcitabine and docetaxel followed by ifosfamide and adriamycin). CONCLUSION: We recommend that new skin lesions within or adjacent to radiation ports should be considered for biopsy. Also, for lesions that are larger, ill-defined, or both, several sites should be sampled to ensure an accurate diagnosis and to prevent the possibility  of a false negative interpretation.

 

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[400]

TÍTULO / TITLE:  - Large pericoronal radiolucency. Odontogenic myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gen Dent. 2012 Nov-Dec;60(6):549-50.

AUTORES / AUTHORS:  - Damm DD

 

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[401]

TÍTULO / TITLE:  - Pharmacologic Inhibition of Epigenetic Modification Reveals Targets of Aberrant Promoter Methylation in Ewing Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2013 Mar 18. doi: 10.1002/pbc.24526.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24526

AUTORES / AUTHORS:  - Nestheide S; Bridge JA; Barnes M; Frayer R; Sumegi J

INSTITUCIÓN / INSTITUTION:  - Faculty of Medicine, Division of Bone Marrow Transplantation and Immune Deficiency, Blood and Cancer Research Institute, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.

RESUMEN / SUMMARY:  - BACKGROUND: Ewing sarcoma (ES), a highly aggressive tumor of children and young adults, is characterized most commonly by an 11;22 chromosomal translocation that fuses EWSR1 located at 22q12 with FLI1, coding for a member of the ETS family of  transcription factors. Although genetic changes in ES have been extensively researched, our understanding of the role of epigenetic modifications in this neoplasm is limited. PROCEDURE: In an effort to improve our knowledge in the role of epigenetic changes in ES we evaluated the in vitro antineoplastic effect of the DNA methyltransferase inhibitor 5-Aza-deoxycytidine (5-Aza-dC) and identified epigenetically silenced genes by pharmacologic unmasking of DNA methylation coupled with genome-wide expression profiling. RESULTS: Comparisons between untreated and 5-Aza-dC treated ES cell lines (n = 5) identified 208 probe sets with at least twofold difference in expression (P </= 0.05). The 208 probe sets represented 145 upregulated and 31 down-regulated genes. Of the 145 genes upregulated after 5-Aza-dC treatment, four: were further characterized. ACRC, CLU, MEST, and NNAT were found to be hypermethylated and transcriptionally down-regulated in ES cell lines. Further studies revealed that ACRC, CLU, MEST, and NNAT were often hypermethylated in primary ES tumors. Transfection-mediated reexpression of ACRC, CLU, MEST, and NNAT in ES cell lines resulted in decreased  growth in culture. CONCLUSIONS: This study demonstrated epigenetically modified genes in ES cell lines and primary tumors and suggested that epigenetic dysregulation may contribute to disease pathogenesis in ES. Pediatr Blood Cancer  2013;9999:xxx-xxx. © 2013 Wiley Periodicals, Inc.

 

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[402]

TÍTULO / TITLE:  - Anthracycline induced cardiac toxicity in pediatric Ewing sarcoma: A longitudinal study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2013 May;60(5):842-8. doi: 10.1002/pbc.24404. Epub 2013 Feb 4.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24404

AUTORES / AUTHORS:  - Brown TR; Vijarnsorn C; Potts J; Milner R; Sandor GG; Fryer C

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Hematology, Oncology & Bone Marrow Transplantation, The British Columbia Children’s Hospital, Vancouver, British Columbia, Canada. tanya.brown@saskcancer.ca, tbrown@cw.bc.ca.

RESUMEN / SUMMARY:  - BACKGROUND: Reports on incidence and factors associated with anthracycline cardiotoxicity in patients with Ewing sarcoma vary and few studies evaluate effect over time. Longitudinal trends in cardiac function and prognostic value of % decline in ejection fraction (EF) during therapy have not been previously described in Ewing sarcoma. PROCEDURE: A retrospective review of patients age <17 years, diagnosed with Ewing sarcoma during 1978-2006, treated at British Columbia Children’s Hospital with anthracycline chemotherapy was undertaken. Echocardiograms performed pre-treatment, worst function during treatment, on therapy completion; worst function during surveillance and the most recent echocardiogram were reviewed. Cardiac toxicity was graded using Common Terminology Criteria for Adverse Events v 3.0 and 4.0. RESULTS: Among 71 eligible patients, median age at diagnosis 11.1 years, median cumulative dose of anthracycline was 365 mg/m(2) . There were 397 echocardiograms with 153 (39%) abnormal. There were 21/71 patients with EF < 50%, 11 with EF < 40% and five cardiac deaths including 2/3 patients post-cardiac transplant. The median time to worst cardiac function was 51 months. Post-therapy completion 16/71 patients with progressive decline in cardiac function were noted. No patient with 10-15% decline in EF during therapy developed cardiotoxicity. Younger age (P = 0.004) and low BMI (P = 0.034) as continuous variables with anthracycline administration by IV push (P = 0.03) were risk factors for cardiotoxicity on univariate analysis but not significant within logistic regression models. CONCLUSIONS: The high incidence of cardiotoxicity associated with higher administered anthracycline dose, young age, bolus infusion, and EF decline warrants evaluation in a larger cohort. Pediatr Blood Cancer 2013; 60: 842-848. © 2013 Wiley Periodicals, Inc.

 

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[403]

TÍTULO / TITLE:  - Endothelin-1 enhances cell migration through COX-2 up-regulation in human chondrosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochim Biophys Acta. 2013 Mar 21. pii: S0304-4165(13)00092-5. doi: 10.1016/j.bbagen.2013.03.014.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bbagen.2013.03.014

AUTORES / AUTHORS:  - Wu MH; Chen LM; Hsu HH; Lin JA; Lin YM; Tsai FJ; Tsai CH; Huang CY; Tang CH

INSTITUCIÓN / INSTITUTION:  - Graduate Institute of Basic Medical Science, China Medical University, Taichung,  Taiwan.

RESUMEN / SUMMARY:  - BACKGROUND: Chondrosarcoma is a type of highly malignant tumor with a potent capacity of local invasion and distant metastasis. The effect of endothelin-1 (ET-1) on migration activity in human chondrosarcoma cells is not clearly understood. Here, we found that ET-1 increased the migration and expression of cyclooxygenase (COX)-2 in human chondrosarcoma cells. METHODS: ET-1-mediated COX-2 expression was assessed by qPCR and Western blot analysis. The mechanisms of action of ET-1 in different signaling pathways were studied using Western blotting. Knockdown of proteins was achieved by transfection with siRNA. Chromatin immunoprecipitation assays were used to study in vivo binding of c-Jun  to the COX-2 promoter. RESULTS: Human chondrosarcoma tissues had significant expression levels of ET-1 and COX-2, which were higher than that in normal cartilage. Exogenous ET-1 increased cell migration and the expression of COX-2. In addition, COX-2 protein levels and cell migration ability were abolished by ET receptor antagonists. Activation of the mitogen-activated protein kinase (MAPK) and activator protein-1 (AP-1) pathways after ET-1 treatment was demonstrated, and ET-1-induced COX-2 expression and cell migration activity were inhibited by the specific inhibitor and mutant of MAPK and AP-1 cascades. ET-1 increased the binding of c-Jun to the AP-1 element on the COX-2 promoter. Furthermore, knockdown of ET-1 decreased cell metastasis in vitro and in vivo. CONCLUSIONS: Our results indicated that ET-1 enhances the cell migration of chondrosarcoma by  increasing COX-2 expression through the ET receptors, MAPK, and AP-1 signal transduction pathway. GENERAL SIGNIFICANCE: We link high ET-1 and COX-2 expression to chondrosarcoma.

 

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[404]

TÍTULO / TITLE:  - Reducing surgical margins in dermatofibrosarcoma protuberans using the pathological analysis technique ‘vertical modified technique’: A 5-year experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Plast Reconstr Aesthet Surg. 2013 May;66(5):617-22. doi: 10.1016/j.bjps.2013.01.016. Epub 2013 Feb 16.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bjps.2013.01.016

AUTORES / AUTHORS:  - Hersant B; May P; Battistella M; Pages C; Lebbe C; Revol M

INSTITUCIÓN / INSTITUTION:  - Plastic and Reconstructive Surgery Department, Hopital Saint Louis, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Assistance Publique Hopitaux de  Paris, France. Electronic address: barbara.hersant@gmail.com.

RESUMEN / SUMMARY:  - BACKGROUND: For the treatment of dermatofibrosarcoma protuberans (DFSP), wide surgical excision has been recommended, with 3-5-cm margins, including the first  underlying clear fascia. Since 2006, a technical improvement in pathological analysis called the vertical modified technique (VMT) has allowed us to reduce the surgical margin without increased oncological risk. METHODS: Between 2006 and 2011, 66 cases of DFSP were analysed in our hospital, using VMT. We reviewed patient records, considering the initial margin, total margin, number of surgeries and outcomes. Functional and aesthetic consequences were assessed by the surgeon and by the patients. RESULTS: Mean initial margin for the first resection was 18 mm (10-30 mm). First resection allowed complete resection of the tumour in 52 cases (78.8%). Mean total surgical margin was 21.3 mm (10-60 mm). There were no cases of local tumour recurrence at a median follow-up of 30 months. Reconstruction was performed using direct sutures in 53 cases (80.3%), split-thickness skin grafts in six cases (9.1%), full-thickness skin grafts in five cases (7.6%) and flaps in two patients (3%). For 90.9% of the patients, the  aesthetic result was acceptable, whereas 84.8% patients were satisfied with the functional result. CONCLUSION: VMT reduces surgical margins and allows for extensive analysis of margins. This technique represents a safe and reliable strategy in DFSP, without increasing the risk of recurrence. The outcomes of our  study have confirmed the data from the literature regarding oncological safety.

 

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[405]

TÍTULO / TITLE:  - Hypopharyngeal lipoma causing obstructive sleep apnea: Discovery on dental cone-beam CT.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ear Nose Throat J. 2013 Mar;92(3):E1-4.

AUTORES / AUTHORS:  - Balasundaram A

INSTITUCIÓN / INSTITUTION:  - Department of Biomedical and Diagnostic Sciences, School of Dentistry, University of Detroit Mercy, 2700 Martin Luther King Blvd., Detroit, MI 48208, USA. balasuas@udmercy.edu.

RESUMEN / SUMMARY:  - Cone-beam computed tomography (CBCT) is primarily used for a variety of dental purposes, but it may also yield nondental findings that can have significant implications for patient health. For example, physicians should be aware that CBCT can identify some of the etiopathogenic causes of obstructive sleep apnea, as occurred in the case described in this report. The patient was a 76-year-old man who presented to a dentist for implant therapy. A CBCT that had been performed in preparation for dental implant placement revealed the presence of a  large hypopharyngeal lesion that was obstructing the airway. An otolaryngologist  excised the lesion, which on biopsy proved to be a lipoma. Following removal of the lesion, the patient’s episodic sleep apnea and snoring resolved. Medical physicians should be aware of maxillofacial CBCT technology and its ability to identify lesions that could cause potential life-threatening situations.

 

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[406]

TÍTULO / TITLE:  - Aggressive angiomyxoma of the female pelvic and perineum.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tunis Med. 2013 Jan;91(1):76-7.

AUTORES / AUTHORS:  - Mathlouthi N; Slimani O; Soumaya R; Ben Jilani Sarra B; Ben Temime R; Makhlouf T; Abdelhamid K; Attia L; Chachia A

 

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[407]

TÍTULO / TITLE:  - Left Cerebellopontine Angle Lipoma With Mild Brainstem Compression in a 13-Year-Old Female.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Otol Neurotol. 2013 Mar 15.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MAO.0b013e3182814d6e

AUTORES / AUTHORS:  - Crowson MG; Symons SP; Chen JM

INSTITUCIÓN / INSTITUTION:  - *Department of Otolaryngology-Head and Neck Surgery, and daggerDivision of Neuroradiology, Department of Medical Imaging, University of Toronto, Sunnybrook  Health Sciences Centre, Toronto, Ontario, Canada.

 

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[408]

TÍTULO / TITLE:  - Effects of fish collagen peptides on collagen post-translational modifications and mineralization in an osteoblastic cell culture system.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dent Mater J. 2013;32(1):88-95.

AUTORES / AUTHORS:  - Yamada S; Nagaoka H; Terajima M; Tsuda N; Hayashi Y; Yamauchi M

INSTITUCIÓN / INSTITUTION:  - NC Oral Health Institute, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

RESUMEN / SUMMARY:  - Collagen is one of the most widely used biomaterials for tissue engineering and regenerative medicine. Fish collagen peptides (FCP) have been used as a dietary supplement, but their effects on the cellular function are still poorly understood. The objective of this study was to investigate the effects of FCP on  collagen synthesis, quality and mineralization using an osteoblastic MC3T3-E1 cell culture system. Cells treated with FCP significantly upregulated the gene expression of several collagen modifying enzymes and more collagen was deposited  in the cultures. Collagen in the treated group showed a greater extent of lysine  hydroxylation, higher levels of hydroxylysine-aldehyde derived cross-links and accelerated cross-link maturation compared with the untreated group. Furthermore, the treated group showed accelerated matrix mineralization. These results indicate that FCP exerts a positive effect on osteoblastic cells in terms of collagen synthesis, quality and mineralization, thereby suggesting the potential  utility of FCP for bone tissue engineering.

 

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[409]

TÍTULO / TITLE:  - Resection of an Intrapericardial Lipoma with Nonsustained Ventricular Tachycardia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Card Surg. 2013 Mar 28. doi: 10.1111/jocs.12095.

            ●● Enlace al texto completo (gratuito o de pago) 1111/jocs.12095

AUTORES / AUTHORS:  - Taguchi S; Mori A; Suzuki R; Ishida O; Hasegawa I; Irie R

INSTITUCIÓN / INSTITUTION:  - Department of Cardiovascular Surgery, Kawasaki Municipal Hospital, Kawasaki, Japan.

RESUMEN / SUMMARY:  - A 35-year-old female presented with nonsustained ventricular tachycardia (NSVT) and a large intrapericardial mass. The mass was attached to the left ventricular  wall with a broad stalk. On histopathology, the tumor was diagnosed as a lipoma.  Postoperatively, the NSVT disappeared.

 

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[410]

TÍTULO / TITLE:  - Parasitic myomas after laparoscopic-assisted myomectomy in multiple endocrine neoplasia type 1.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Obstet Gynaecol Res. 2013 Mar 17. doi: 10.1111/jog.12009.

            ●● Enlace al texto completo (gratuito o de pago) 1111/jog.12009

AUTORES / AUTHORS:  - Takeda A; Sakurai A; Imoto S; Nakamura H

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.

RESUMEN / SUMMARY:  - Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary disorder that develops multiple tumors arising from various endocrine  organs, including the parathyroid gland, endocrine pancreas and pituitary gland.  Although mesenchymal tumors can be an integral part of the syndrome, parasitic peritoneal myomas have never been described in an MEN1 patient. Seven years after laparoscopic-assisted myomectomy, parasitic peritoneal myomas were diagnosed in a 31-year-old woman with situs inversus totalis and previous history of parathyroid adenoma. Subsequently, MEN1 was clinically diagnosed by identification of endocrine pancreatic, adrenal and pituitary tumors. Genetic analysis revealed a heterozygous germline mutation in the splice donor sequence of intron 6 of the MEN1 gene. Although rare, parasitic peritoneal myomas could potentially be associated with MEN1 syndrome.

 

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[411]

TÍTULO / TITLE:  - Array comparative genomic hybridization in osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Methods Mol Biol. 2013;973:227-47. doi: 10.1007/978-1-62703-281-0_15.

            ●● Enlace al texto completo (gratuito o de pago) 1007/978-1-62703-281-0_15

AUTORES / AUTHORS:  - Sadikovic B; Park PC; Selvarajah S; Zielenska M

INSTITUCIÓN / INSTITUTION:  - Department of Molecular and Human Genetics, Baylor College of Medicine, Houston,  TX, USA, sadikovic@hhsc.ca.

RESUMEN / SUMMARY:  - Osteosarcoma, the most frequent primary bone tumor, is a malignant mesenchymal sarcoma with a peak incidence in young children and adolescents. Left untreated,  it progresses relentlessly to local and systemic disease, ultimately leading to death within months. Genomically, osteosarcomas are aneuploid with chaotic karyotypes, lacking the pathognomonic genetic rearrangements characteristic of most sarcomas. The familial genetics of osteosarcoma helped in elucidating some of the etiological molecular disruptions, such as the tumor suppressor genes RB1  in retinoblastoma and TP53 in Li-Fraumeni, and RECQL4 involved in DNA repair/replication in Rothmund-Thomson syndrome. Genomic profiling approaches such as array comparative genomic hybridization (aCGH) have provided additional insights concerning the mechanisms responsible for generating complex osteosarcoma genomes. This chapter provides a brief introduction to the clinical  features of conventional osteosarcoma, the predominant subtypes, and a general overview of materials and analytical methods of osteosarcoma aCGH, followed by a  more detailed literature overview of aCGH studies and a discussion of emerging genes, molecular mechanisms, and their clinical implications, as well as more recent application of integrative genomics in osteosarcoma. aCHG is helping elucidate genomic events leading to tumor development and evolution as well as identification of prognostic markers and therapeutic targets in osteosarcoma.

 

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[412]

TÍTULO / TITLE:  - Hemangioblastoma-like clear cell stromal tumor of the lung.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Adv Anat Pathol. 2013 Mar;20(2):130-5. doi: 10.1097/PAP.0b013e318286245d.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAP.0b013e318286245d

AUTORES / AUTHORS:  - Falconieri G; Mirra M; Michal M; Suster S

INSTITUCIÓN / INSTITUTION:  - Department of Anatomic Pathology, General University Hospital of Udine, Udine, Italy. falconieri.giovanni@aoud.sanita.fvg.it

RESUMEN / SUMMARY:  - The authors report 2 cases of an apparently unpublished stromal tumor of the lung characterized by a predominantly endobronchial growth pattern and benign-appearing clear cells. Both tumors were discovered incidentally in adult patients during routine workups for other medical reasons and treated with lobectomy. On gross inspection there was no evidence of infiltration of the adjacent lung tissue. Microscopically, both lesions featured monotonous oval-shaped to spindle-shaped cells growing in a vaguely nested pattern. The cytoplasm was slightly vacuolated or granular. In 1 case there was a variable admixture with mature fat. Immunohistochemistry was negative for markers of epithelial and stromal differentiation except for vimentin. A focal reaction for  CD34 was seen in 1 case. No mutation of coding sequence of VHL gene was seen in one case. Medical follow-up at 1 year was negative for tumor recurrence or metastases. The broad differential diagnosis within the spectrum of stromal lung  tumor is discussed. Owing to distinctive microscopic features such as the nesting of clear cells within a vascularized background, both tumors appeared similar to  hemangioblastoma, although the expected immunohistochemical profile of the latter was not fully expressed. Because of pattern of growth seen in both lesions we believe that the appellation of endobronchial, hemangioblastoma-like clear cell stromal tumor may be provisionally designed.

 

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[413]

TÍTULO / TITLE:  - Fibroma of the tendon sheath - a rare hand tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pol Przegl Chir. 2012 Dec 1;84(12):651-6. doi: 10.2478/v10035-012-0107-z.

            ●● Enlace al texto completo (gratuito o de pago) 2478/v10035-012-0107-z

AUTORES / AUTHORS:  - Heckert R; Bear J; Summers T; Frew M; Gwinn D; McKay P

RESUMEN / SUMMARY:  - Abstract Fibroma of the tendon sheath (FTS) is a rare, benign, soft tissue lesion. Clinically, FTS presents similarly to the more common giant cell tumor of the tendon sheath. It is distinguished histologically by the lack of giant cells, foamy histiocytes and synovial cells. We presented a case of FTS involving the common tendon sheath surrounding the flexor tendons leading to the third metacarpal. A 63-year-old man presented with a 3-month history of a painless mass in his right palm that had recently tripled in size. Examination demonstrated a 5x4 cm firm, nodular, superficial mass that was adherent to the overlying skin. Radiographs of the hand revealed a soft tissue mass without bony abnormality. Ultrasound demonstrated a solid, heterogeneous and hypoechoic mass and computed tomography demonstrated that the mass centered predominantly at the mid and distal portions of the third metacarpal. The patient underwent excisional biopsy  of the lesion and a palmar, longitudinal incision was made from the wrist to the  third metacarpal. Submitted histologic sections revealed a well-circumscribed lesion closely resembling hyalinized collagen. Neither vascular proliferations, necrosis, nor mitoses were observed. Similarly, multinucleated giant cells, pigment-laden macrophages, and inflammatory cells were also not identified. A diagnosis of FTS was rendered. We provided an additional rare case to the literature of a FTS and highlight the need to consider this entity in the differential diagnosis for any soft tissue lesion in the hand. Three months post  surgery the patient demonstrated full range of motion of the hand.

 

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[414]

TÍTULO / TITLE:  - Non-Islet Cell Tumor Hypoglycemia Associated with Recurrent Carcinosarcoma of the Ovary.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Endocr Pract. 2013 Mar 19:1-13.

            ●● Enlace al texto completo (gratuito o de pago) 4158/EP13002.CR

AUTORES / AUTHORS:  - Kojima G; Terada KY; Miki N; Miki K

INSTITUCIÓN / INSTITUTION:  - The John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii.

RESUMEN / SUMMARY:  - Objective: To describe the first reported case of non-islet cell tumor hypoglycemia (NICTH) associated with carcinosarcoma of the ovary.Methods: We report the clinical course, imaging and pathologic findings, and relevant literature review.Results: A 48-year-old woman had a surgery to remove ovarian masses, which turned out to be carcinosarcoma of the ovary, stage IIIc. However she declined postoperative adjuvant chemotherapy. Six months later, she became unconscious with severe hypoglycemia. A large pelvic mass was found and thought to represent a recurrence. Serum insulin and C-peptide were undetectable. Morning cortisol was mildly elevated. Thyroid stimulating hormone, amylase, lipase, and renal and hepatic functions were normal. While insulin-like growth factor (IGF)-I was low, IGF-II was inappropriately elevated. Increased IGF-II/IGF-I ratio was suggestive of NICTH in light of the large pelvic tumor. She required frequent meals, dextrose boluses and continuous infusions, oral prednisone, and glucagon continuous infusion to prevent recurrent hypoglycemic attacks. Chemotherapy with  carboplatin and paclitaxel was initiated and glucose control started to improve.  After four cycles of the chemotherapy, the tumor regressed substantially and was  surgically removed. She had three more cycles of postoperative chemotherapy. Although reported median survival of this aggressive neoplasm is less than two years, this patient has been free of recurrent disease and hypoglycemia for six years.Conclusion: This is the first study to report NICTH in a patient with carcinosarcoma of the ovary. Clinicians should be aware of NICTH as a cause of hypoglycemia especially in a patient with a tumor or history of tumor.

 

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[415]

TÍTULO / TITLE:  - Another cystic lesion in the calcaneus: benign fibrous histiocytoma of bone.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Am Podiatr Med Assoc. 2013 Mar-Apr;103(2):141-4.

AUTORES / AUTHORS:  - Keskinbora M; Kose O; Karslioglu Y; Demiralp B; Basbozkurt M

INSTITUCIÓN / INSTITUTION:  - Orthopaedics and Traumatology Department, Gulhane Military Medical Academy, Ankara, Turkey.

RESUMEN / SUMMARY:  - Benign fibrous histiocytoma is a rare benign primary skeletal tumor that occurs frequently in the long bones and the pelvis. The calcaneus is an unusual location for benign fibrous histiocytoma. We did not identify any case of benign fibrous histiocytoma involving the calcaneus in the relevant literature. We describe a 22-year-old male patient with benign fibrous histiocytoma involving the calcaneus treated with curettage and bone grafting. At the final follow-up visit, 1 year after surgery, the patient was free of pain and walking unaided. We discuss the differential diagnosis of cystic lesions of the calcaneus.

 

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[416]

TÍTULO / TITLE:  - Malignant solitary fibrous tumor with hypoglycemia (Doege-Potter syndrome).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Postgrad Med. 2013 Jan-Mar;59(1):64-6. doi: 10.4103/0022-3859.109503.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0022-3859.109503

AUTORES / AUTHORS:  - Yang CY; Chou CW; Hao LJ

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, Kaohsiung Veteran General Hospital Tainan Branch; Department of Optometry, Chung Hwa University of Medical and Technology,  Tainan, Taiwan, Republic of China.

 

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[417]

TÍTULO / TITLE:  - Cardiac Angiofibroma: A Rare Primary Cardiac Tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Card Surg. 2013 Feb 26. doi: 10.1111/jocs.12081.

            ●● Enlace al texto completo (gratuito o de pago) 1111/jocs.12081

AUTORES / AUTHORS:  - Issa OM; Reyna J; Santana O; Debeer S; Lapietra A; Lamelas J

INSTITUCIÓN / INSTITUTION:  - Division of Internal Medicine at Mount Sinai Medical Center, Mount Sinai Heart Institute, Miami Beach, Florida.

RESUMEN / SUMMARY:  - Cardiac angiofibromas are rare tumors. We report a patient with an angiofibroma of the mitral valve and discuss the management of these tumors.

 

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[418]

TÍTULO / TITLE:  - Hereditary gingival fibromatosis with distinctive facies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Contemp Dent Pract. 2012 Nov 1;13(6):892-6.

AUTORES / AUTHORS:  - Prasad SS; Radharani C; Sinha S; Kumar SK

INSTITUCIÓN / INSTITUTION:  - Department of Periodontics, Drs Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Krishna, Andhra Pradesh, India.

RESUMEN / SUMMARY:  - Hereditary gingival enlargement also known as gingivitis or familial elephantiasis is a rare type of gingival enlargement. It appears as an isolated autosomal dominant disorder or maybe associated with other conditions. Oral manifestations may vary from minimal involvement of only tuberosity area and the  buccal gingiva around the lower molars to a generalized enlargement inhibiting eruption of the teeth. This paper discusses the case of a 13-year-old female patient with distinctive facial characteristics who presented to the department with a chief complaint of swollen gums since 1 year. She had severe diffuse gingival enlargement of the maxilla and mandible. Diagnosis was made based upon clinical examination and family history. Quadrant wise internal bevel gingivectomy procedure was done for the patient to restore her functional and esthetic needs.

 

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[419]

TÍTULO / TITLE:  - Enhanced osteoblastic cell response on zirconia by bio-inspired surface modification.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Colloids Surf B Biointerfaces. 2013 Jun 1;106:37-45. doi: 10.1016/j.colsurfb.2013.01.023. Epub 2013 Jan 23.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.colsurfb.2013.01.023

AUTORES / AUTHORS:  - Liu YT; Lee TM; Lui TS

INSTITUCIÓN / INSTITUTION:  - Department of Materials Science and Engineering, National Cheng Kung University,  Tainan, Taiwan.

RESUMEN / SUMMARY:  - Excellent esthetic properties and limited plaque adhesion make zirconia ceramics  an ideal material for implants in the fields of dentistry and orthopedics. Unfortunately, the physicochemical stability of zirconia makes it difficult to improve biocompatibility through surface modification. The dopamine-derived residue, 3,4-dihydroxy-l-phenylalanine (l-DOPA), has been identified as an important molecule secreted by marine mussels for the formation of adhesive pads. This study coated zirconia with l-DOPA to improve the biocompatibility of ZrO2. As confirmed by contact angle and X-ray photoelectron spectroscopy (XPS), the formation of l-DOPA film can be controlled by varying the process temperature. Results from scanning electron microscopy (SEM) and atomic force microscopy (AFM) show that the topography of the zirconia substrate was preserved after being coated with a film of l-DOPA. Specifically, the thickness of the coating and initial cell spreading ability were both enhanced by preparing samples at higher  temperatures. l-DOPA coated zirconia demonstrated better cyto-compatibility than  uncoated specimens, as indicated by cell responses such as cell spreading and proliferation. These preliminary results suggest that l-DOPA film could be used to improve the cyto-compatibility of zirconia and further has the potential to immobilize other biofunctional molecules in biomedical applications.

 

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[420]

TÍTULO / TITLE:  - Adenomyosis and subfertility: evidence of association and causation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Semin Reprod Med. 2013 Mar;31(2):101-8. doi: 10.1055/s-0032-1333475. Epub 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 1055/s-0032-1333475

AUTORES / AUTHORS:  - Tomassetti C; Meuleman C; Timmerman D; D’Hooghe T

INSTITUCIÓN / INSTITUTION:  - Department Obstetrics and Gynecology, Leuven University Fertility Center, Leuven, Belgium.

RESUMEN / SUMMARY:  - Due to the confounding or unknown presence of endometriosis in both cases and controls, it is difficult to test the hypothesis that adenomyosis causes infertility. Based on the limited available evidence, there is evidence to support a causal association between adenomyosis and subfertility: Adenomyosis is associated with lifelong infertility in baboons, is associated with impaired reproductive outcome after assistive reproductive technique, and a dose-effect relationship between the degree of adenomyosis and the degree of abnormal uterotubal contractility has been demonstrated. More and better designed studies  are needed to assess the impact of adenomyosis on infertility in women with the laparoscopic-proven presence or absence of endometriosis.

 

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[421]

TÍTULO / TITLE:  - Thoracoscopic enucleation of a giant leiomyoma of the esophagus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Surg Laparosc Endosc Percutan Tech. 2013 Feb;23(1):e32-4. doi: 10.1097/SLE.0b013e318275b2a3.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SLE.0b013e318275b2a3

AUTORES / AUTHORS:  - Iscan Y; Tunca F; Senyurek YG; Tezelman S; Terzioglu T

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Capa, Topkapi, Istanbul, Turkey.

RESUMEN / SUMMARY:  - Minimally invasive surgery has gained a rapid development and popularity in the recent years. With these developments in minimally invasive surgery, video-thoracoscopic approaches has become more frequently preferred interventions for benign esophageal lesions. Herein, we report a case of a giant esophageal leiomyoma which was successfully enucleated by video-thoracoscopic approach without any peroperative or postoperative complications.

 

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[422]

TÍTULO / TITLE:  - Intraperitoneal accessory spleen and adrenal myelolipoma: removal by simultaneous bilateral posterior retroperitoneoscopy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Surg Laparosc Endosc Percutan Tech. 2013 Feb;23(1):e29-31. doi: 10.1097/SLE.0b013e3182680c13.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SLE.0b013e3182680c13

AUTORES / AUTHORS:  - Wu ZS; Chiou SS; Lee JY; Chang YT

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, College of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

RESUMEN / SUMMARY:  - Posterior retroperitoneoscopic approach (PRA) has become an established procedure for retroperitoneal lesions. The authors encountered a 30-year-old male patient who had beta-thalassemia major and received splenectomy 15 years previously. Bilateral suprarenal tumors were noted on follow-up sonography. Subsequent computed tomography of the abdomen showed a right adrenal tumor and a left intraperitoneal lesion with homogenous enhancement. Successful bilateral PRA was  performed, and histology confirmed the diagnosis of right adrenal myelolipoma and an accessory spleen. For the present case who had a large abdominal scar, PRA is  technically feasible for treating patients with intraperitoneal and/or retroperitoneal suprarenal lesions while eliminating the necessity of dissection  for intra-abdominal adhesions and patient repositioning for bilateral lesions.

 

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[423]

TÍTULO / TITLE:  - Paranasal sinus osteoma: is there any association with anatomical variations?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Rhinology. 2013 Mar;51(1):54-60. doi: 10.4193/Rhin.

            ●● Enlace al texto completo (gratuito o de pago) 4193/Rhin

AUTORES / AUTHORS:  - Janovic A; Antic S; Rakocevic Z; Djuric M

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, University of Belgrade, Belgrade, Serbia.

RESUMEN / SUMMARY:  - BACKGROUND: Developmental disturbances of the paranasal sinuses are proposed as the cause of osteoma. We examined whether such disturbances may result in the frequent presence of anatomical variations of the paranasal sinuses in patients with osteoma. METHODOLOGY/PRINCIPAL: The study was performed retrospectively on 2,820 patients subjected to CT examination during 2005 - 2011. Demographic and CT characteristics of osteoma, and associated pathological findings were evaluated for 104 patients with diagnosed osteoma. The presence of anatomical variations was assessed for 51 osteoma patients with a complete medical history, and for 1,233 patients from a control group. RESULTS: The prevalence of osteomas was found to be 3.69%, with male to female ratio 1.08:1. The frontal sinus was most commonly affected. The presence of anatomical variations was more frequent in patients with osteoma than in controls, with significant differences confirmed for the sphenomaxillary plate, infraorbital cell, and crista galli pneumatization. CONCLUSIONS: The paranasal sinus osteoma is associated with higher prevalence of anatomical variations. This can be explained either by the stronger influence of genetic and/or environmental factors on the development of  the paranasal sinuses in patients with osteoma, or by their higher susceptibility to above mentioned factors.

 

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[424]

TÍTULO / TITLE:  - An Unusual Presentation of a Small-size Synovial Sarcoma With an Indolent Course  of Over 30 Years: A Cautionary Tale!

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Appl Immunohistochem Mol Morphol. 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAI.0b013e318280f4c1

AUTORES / AUTHORS:  - Kurt H; Mayerson JL; Iwenofu OH

INSTITUCIÓN / INSTITUTION:  - Departments of *Pathology and Laboratory Medicine daggerOrthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH.

 

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[425]

TÍTULO / TITLE:  - Targeting FoxM1 effectively retards p53-null lymphoma and sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Cancer Ther. 2013 Feb 20.

            ●● Enlace al texto completo (gratuito o de pago) 1158/1535-7163.MCT-12-0903

AUTORES / AUTHORS:  - Wang Z; Zheng Y; Park HJ; Li J; Carr JR; Chen YJ; Kiefer MM; Kopanja D; Bagchi S; Tyner AL; Raychaudhuri P

INSTITUCIÓN / INSTITUTION:  - 1Biochemistry and Molecular Genetics M/C 669, University of Illinois, Chicago.

RESUMEN / SUMMARY:  - The forkhead box transcription factor FOXM1 is considered to be a promising target for cancer therapy. However, the significance of FOXM1 in tumors harboring mutation in p53, which is very common, is unclear. In this study, we investigated the efficacy of FoxM1-targeting in spontaneous p53-null tumors using genetic ablation as well as using a peptide-inhibitor of FOXM1. We show that conditional  deletion of FoxM1 inhibits growth of the p53 null thymic lymphoma and sarcoma cells. In addition, deletion of FoxM1 induces apoptotic cell death of the p53 null tumors, accompanied by reduced expression of the FOXM1 target genes Survivin and Bmi1. An ARF-derived peptide that inhibits the activity of FOXM1, by targeting it to the nucleolus, also induces apoptosis in the p53 null sarcoma and lymphoma, leading to a strong inhibition of their metastatic colonization. Together, our observations suggest that FOXM1 is critical for survival and growth of the p53-null lymphoma and sarcoma, and provide proof-of-principle that FOXM1 is an effective therapeutic target for sarcoma and lymphoma carrying loss of function mutation in p53.

 

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[426]

TÍTULO / TITLE:  - Metastasis of femoral osteosarcoma to the abdominal wall detected on 99m Tc-MDP skeletal scintigraphy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Nucl Med. 2013 Mar 2.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12149-013-0708-6

AUTORES / AUTHORS:  - Pirayesh E; Rakhshan A; Amoui M; Rakhsha A; Poor AS; Assadi M

INSTITUCIÓN / INSTITUTION:  - Department of Nuclear Medicine, Shohada e Tajrish Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

RESUMEN / SUMMARY:  - Osteosarcoma is the most frequent primary malignancy of bone, and usually metastasizes to the lung and bones, while other sites are rare. In most reported  cases, soft tissue metastasis of osteosarcoma is unusual, and only develops in the advanced stages of the disease, especially following multiple recurrences. We present a patient with recently diagnosed osteosarcoma of the right femur, showing abdominal wall metastasis diagnosed by technetium-99m-methylene diphosphonate (99m Tc-MDP) whole body bone scintigraphy and confirmed histologically. The present case highlights the importance of whole body imaging  of patients with osteosarcoma for detecting unusual sites of metastasis, especially in soft tissue organs.

 

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[427]

TÍTULO / TITLE:  - Pseudomyogenic hemangioendothelioma (epithelioid sarcoma-like hemangioendothelioma, fibroma-like variant of epithelioid sarcoma) of the thoracic spine.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Spine J. 2013 Feb 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00586-013-2727-3

AUTORES / AUTHORS:  - McGinity M; Bartanusz V; Dengler B; Birnbaum L; Henry J

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl drive, San Antonio, TX, 78229-3900, USA.

RESUMEN / SUMMARY:  - PURPOSE: Pseudomyogenic hemangioendothelioma is a soft tissue tumor found in young adults, predominantly males. The tumor has been reported in various locations in the body, including the head, neck, chest wall, abdominal wall, genital region, and extremities. Until now, there has been no indication of occurrence in the spine. METHODS: A 25-year-old male presented with spinal cord compression, due to an extradural tumor involving the third and fourth thoracic vertebrae with extension into the right pleural cavity. RESULTS: Histopathologic  examination revealed a pseudomyogenic hemangioendothelioma, also described as epithelioid sarcoma-like hemangioendothelioma, or fibroma-like variant of epithelioid sarcoma. CONCLUSION: We describe the first occurrence of pseudomyogenic hemangioendothelioma in the thoracic spine. According to previous  reports based on other locations, the tumor has an indolent clinical course with  a small risk of metastasis, therefore complete macroscopic excision is the treatment of choice. Local recurrence may occur even with complete surgical resection, requiring close follow-up; adjuvant therapy is warranted.

 

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[428]

TÍTULO / TITLE:  - Subcutaneous fluid port-associated soft tissue sarcoma in a cat.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Feline Med Surg. 2013 Feb 14.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1098612X13478267

AUTORES / AUTHORS:  - McLeland SM; Imhoff DJ; Thomas M; Powers BE; Quimby JM

INSTITUCIÓN / INSTITUTION:  - 1Department of Microbiology, Immunology, and Pathology Colorado State University, Fort Collins, CO, USA.

RESUMEN / SUMMARY:  - A 20-year-old male castrated domestic longhair cat was evaluated for assessment of its chronic kidney disease (CKD) and a non-healing ulcerated mass at the site  of a previously placed and subsequently removed GIF-tube. The cat had been diagnosed with CKD 10 years prior and two GIF tubes had been placed over a 5-year period, the second of which was associated with secondary infection. Biopsy of the non-healing ulcerated mass was consistent with grade 2 soft tissue sarcoma. At necropsy there was a discrete, serpentine, subcutaneous mass measuring approximately 8 mm in diameter that extended approximately 20 cm along the dorsum to the caudal thorax, following the path of the GIF-tube, from the main intrascapular, ulcerated mass where the fluid port injection site was located. This is the first report of a fibrosarcoma arising at the site of a subcutaneous  fluid port in a cat. Although the cat’s owners were pleased with the 4 years of quality of life provided by this device, this complication should be considered when a decision to place ports for long-term management of disease is made.

 

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[429]

TÍTULO / TITLE:  - Malignant transformation of orbital solitary fibrous tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int Ophthalmol. 2013 Mar 23.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10792-012-9637-y

AUTORES / AUTHORS:  - Wang X; Qian J; Bi Y; Ping B; Zhang R

INSTITUCIÓN / INSTITUTION:  - Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai,  200031, China.

RESUMEN / SUMMARY:  - Orbital solitary fibrous tumor (SFT) is a rare tumor and may recur or undergo malignant transformation without complete excision. We present a case of orbital  SFT which recurred twice and underwent malignant transformation. The patient was  treated with en bloc excision via a lateral orbitotomy. The postoperative histopathologic diagnosis of this case was an adult fibrosarcoma. Postoperative adjuvant radiation therapy was given. In 18 months of further follow-up, there has been no evidence of recurrence, both clinically and in regular imaging studies.

 

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[430]

TÍTULO / TITLE:  - Left ventricular myxoma producing cardiac failure.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Heart Surg Forum. 2013 Feb 1;16(1):E57-9. doi: 10.1532/HSF98.20121063.

            ●● Enlace al texto completo (gratuito o de pago) 1532/HSF98.20121063

AUTORES / AUTHORS:  - Simsek E; Durdu S; Hodo B; Yazicioglu L; Uysalel A

INSTITUCIÓN / INSTITUTION:  - Department of Cardiovascular Surgery, Etlik Ihtisas Training and Research Hospital, Ankara, Turkey. erdaldr@yahoo.com

RESUMEN / SUMMARY:  - INTRODUCTION: Seventy-five percent of primary cardiac tumors are benign, and most are myxomas. Seventy-five percent of myxomas originate from the left atrium, and  2.5% arise from the left ventricle. Heart failure is a rare complication of myxoma. CASE: A 54-year-old male patient with chronic obstructive pulmonary disease was admitted to the pulmonology department with a diagnosis of pneumonia  and congestive heart failure during hospitalization. An echocardiography evaluation revealed a mobile mass (3.3 cm X 1.2 cm) in the left ventricle. The measured ejection fraction was 22%. Transthoracic and transesophageal echocardiography and magnetic resonance imaging examinations confirmed the presence of a myxoma in the left ventricle. The myxoma was a hanging mass with a  stalk on the interventricular septum near the anterior mitral valve annulus. We visualized the gelatinous fragile mass on the septum; we then extracted the myxoma via a transaortic approach with the patient on cardiopulmonary bypass. The patient was discharged 10 days after surgery. DISCUSSION: Myxoma is treated by early surgical resection because of the potential for serious complications. Left ventricular myxomas have been reported to lead to a silent heart failure. This case is important because of its location and the patient’s resultant heart failure.

 

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[431]

TÍTULO / TITLE:  - The coexistence of clear cell renal cell carcinoma and gastrointestinal stromal tumor with portal vein metastasis, and its favorable response to sunitinib.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Expert Rev Anticancer Ther. 2013 Feb;13(2):131-6. doi: 10.1586/era.12.162.

            ●● Enlace al texto completo (gratuito o de pago) 1586/era.12.162

AUTORES / AUTHORS:  - Tao J; Ni C; Jin Y; Yuchun Z; Peng Z; Yuru Y; Hao Z

INSTITUCIÓN / INSTITUTION:  - Department of Urology, West China Hospital, Sichuan University, Sichuan, China.

RESUMEN / SUMMARY:  - The authors report the case of a 42-year-old man with a rare coexistence of clear cell renal cell carcinoma and gastrointestinal stromal tumor of the stomach with  concurrent portal vein metastasis. After surgical resection of the two original masses, the patient was treated with sunitinib malate to control the portal vein  metastasis. The metastatic lesion completely disappeared after two cycles of treatment. This is the first known reported case of synchronous clear cell renal  cell carcinoma and gastrointestinal stromal tumor with distal metastasis, and the first report of the favorable efficacy and safety of sunitinib in treating this rare synchronous dual malignancy.

 

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[432]

TÍTULO / TITLE:  - Leiomyoma of the vulva.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tunis Med. 2013 Jan;91(1):78-80.

AUTORES / AUTHORS:  - Youssef A; Neji K; M’barki M; Ben Amara F; Malek M; Reziga H

 

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[433]

TÍTULO / TITLE:  - A misleading hepatic tumour: epithelioid angiomyolipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Gastroenterol Belg. 2012 Dec;75(4):443-5.

AUTORES / AUTHORS:  - Limaiem F; Korbi S; Lahmar A; Bouraoui S; Aloui S; Jedidi S; Miloudi N; Mzabi-Regaya S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Mongi Slim Hospital, Sidi Daoued, La Marsa, Tunisia. fatenlimaiem@yahoo.fr

RESUMEN / SUMMARY:  - Hepatic angiomyolipoma (HAML) is a rare, benign mesenchymal neoplasm composed of  varying amounts of smooth muscle cells, adipose tissue, and vessels. Its morphological diversity often poses diagnostic problems. In this paper, the authors report a peculiar case of epithelioid HAML mimicking histologically hepatocellular carcinoma with focal areas resembling inflammatory pseudotumour. A 57 year-old male patient presented with abdominal pain and discomfort. Non enhanced CT scan demonstrated a heterogeneous hypodense mass located in segment II and IV of the liver. Hepatocellular carcinoma was suspected and the patient underwent left lobectomy. Histologically, the tumour was mainly composed of epithelioid cells arranged in trabeculae and sheets (50% of the tumour surface) admixed with mature fat cells (20%) and thick-walled blood vessels. Lymphocytic aggregates and clusters of foamy histiocytes were focally found in the stroma (30%). Most of the epithelioid tumour cells were immunoreactive to homatropine methylbromide 45 (HMB-45) and smooth muscle actin. Morphological pattern and immunophenotype were consistent with epithelioid HAML.

 

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[434]

TÍTULO / TITLE:  - Editorial Comment to Role of mammalian target of rapamycin inhibitor in the treatment of metastatic epithelioid angiomyolipoma: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Urol. 2013 Feb 5. doi: 10.1111/iju.12116.

            ●● Enlace al texto completo (gratuito o de pago) 1111/iju.12116

AUTORES / AUTHORS:  - Nagashima Y

INSTITUCIÓN / INSTITUTION:  - Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan. ynagas@med.yokohama-cu.ac.jp.

 

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[435]

TÍTULO / TITLE:  - Ewing Sarcoma Arising After Treatment of Diffuse Large B-cell Lymphoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Jpn J Clin Oncol. 2013 Apr;43(4):417-21. doi: 10.1093/jjco/hyt011. Epub 2013 Mar  8.

            ●● Enlace al texto completo (gratuito o de pago) 1093/jjco/hyt011

AUTORES / AUTHORS:  - Hiramoto N; Kobayashi Y; Nomoto J; Maruyama D; Watanabe T; Tochigi N; Furuta K; Takeda K; Chuman H; Yagyu S; Hosoi H; Tobinai K

INSTITUCIÓN / INSTITUTION:  - *Department of Hematology, National Cancer Center Hospital, Tokyo, Japan 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ykkobaya@ncc.go.jp.

RESUMEN / SUMMARY:  - We report the case of a patient in whom the diagnosis of Ewing sarcoma arising from a soft tissue was made after successful treatment of diffuse large B-cell lymphoma. A 65-year-old woman presented with a rapidly growing mass in her left scapular region 8 years after successful chemotherapy with the cyclophosphamide,  hydroxydaunomycin hydrochloride, vincristine, prednisolone regimen for diffuse large B-cell lymphoma. Computed tomographic examination and magnetic resonance imaging of the thorax revealed an intramuscular tumour measuring 40 mm in size in the left scapular region. Histopathological examination of an open biopsy specimen revealed a small round cell tumour that showed positive staining for CD99. Fluorescence in situ hybridization showed a split signal by a break-apart probe for the EWS gene in chromosome 22q12. Reverse transcriptase-polymerase chain reaction confirmed the expression of EWS-FLI1 fusion transcripts. Based on  these findings, the patient was diagnosed as having secondary Ewing sarcoma. Despite adjuvant chemotherapy, however, she died of pulmonary metastases 2 years  after the diagnosis of Ewing sarcoma. Therapy-related haematological malignancies with balanced translocations have been reported previously. A mechanism similar to that underlying the development of secondary malignancy might explain the occurrence of this solid cancer.

 

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[436]

- CASTELLANO -

TÍTULO / TITLE:Plevine Ewing-Sarkome : Dreidimensionale konformale vs. intensitatsmodulierte Strahlentherapie.

TÍTULO / TITLE:  - Pelvic Ewing sarcomas : Three-dimensional conformal vs. intensity-modulated radiotherapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Strahlenther Onkol. 2013 Apr;189(4):308-314. Epub 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00066-012-0304-z

AUTORES / AUTHORS:  - Mounessi FS; Lehrich P; Haverkamp U; Willich N; Bolling T; Eich HT

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, University of Munster, Albert-Schweitzer-Campus 1, 48149, Munster, Germany, f@mounessi.com.

RESUMEN / SUMMARY:  - PURPOSE: The goal of the present work was to assess the potential advantage of intensity-modulated radiotherapy (IMRT) over three-dimensional conformal radiotherapy (3D-CRT) planning in pelvic Ewing’s sarcoma. PATIENTS AND METHODS: A total of 8 patients with Ewing sarcoma of the pelvis undergoing radiotherapy were analyzed. Plans for 3D-CRT and IMRT were calculated for each patient. Dose coverage of the planning target volume (PTV), conformity and homogeneity indices, as well as further parameters were evaluated. RESULTS: The average dose coverage  values for PTV were comparable in 3D-CRT and IMRT plans. Both techniques had a PTV coverage of V95 > 98 % in all patients. Whereas the IMRT plans achieved a higher conformity index compared to the 3D-CRT plans (conformity index 0.79 +/- 0.12 vs. 0.54 +/- 0.19, p = 0.012), the dose distribution across the target volumes was less homogeneous with IMRT planning than with 3D-CRT planning. This difference was statistically significant (homogeneity index 0.11 +/- 0.03 vs. 0.07 +/- 0.0, p = 0.035). For the bowel, Dmean and D1%, as well as V2 to V60 were reduced in IMRT plans. For the bladder and the rectum, there was no significant difference in Dmean. However, the percentages of volumes receiving at least doses of 30, 40, 45, and 50 Gy (V30 to V50) were lower for the rectum in IMRT plans. The volume of normal tissue receiving at least 2 Gy (V2) was significantly higher in IMRT plans compared with 3D-CRT, whereas at high dose levels (V30) it was significantly lower. CONCLUSION: Compared to 3D-CRT, IMRT showed significantly better results regarding dose conformity (p = 0.012) and bowel sparing at dose levels above 30 Gy (p = 0.012). Thus, dose escalation in the radiotherapy of pelvic Ewing’s sarcoma can be more easily achieved using IMRT.

 

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[437]

TÍTULO / TITLE:  - Ewing’s sarcoma of the rib in a child.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JBR-BTR. 2012 Nov-Dec;95(6):378.

AUTORES / AUTHORS:  - Van Petegem S; Jans L; Lambrecht V; Huysse W; Verstraete K

INSTITUCIÓN / INSTITUTION:  - Department of Radiology and Medical Imaging, Ghent University Hospital, Gent, Belgium.

 

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[438]

TÍTULO / TITLE:  - The prognostic value of the serum level of C-reactive protein for the survival of patients with a primary sarcoma of bone.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bone Joint J. 2013 Mar;95-B(3):411-8. doi: 10.1302/0301-620X.95B3.30344.

            ●● Enlace al texto completo (gratuito o de pago) 1302/0301-620X.95B3.30344

AUTORES / AUTHORS:  - Nakamura T; Grimer RJ; Gaston CL; Watanuki M; Sudo A; Jeys L

INSTITUCIÓN / INSTITUTION:  - The Royal Orthopaedic Hospital, Oncology Service, Bristol Road South, Northfield, Birmingham B31 2AP, UK.

RESUMEN / SUMMARY:  - The aim of this study was to determine whether the level of circulating C-reactive protein (CRP) before treatment predicted overall disease-specific survival and local tumour control in patients with a sarcoma of bone. We retrospectively reviewed 318 patients who presented with a primary sarcoma of bone between 2003 and 2010. Those who presented with metastases and/or local recurrence were excluded. Elevated CRP levels were seen in 84 patients before treatment; these patients had a poorer disease-specific survival (57% at five years) than patients with a normal CRP (79% at five years) (p < 0.0001). They were also less likely to be free of recurrence (71% at five years) than patients  with a normal CRP (79% at five years) (p = 0.04). Multivariate analysis showed the pre-operative CRP level to be an independent predictor of survival and local  control. Patients with a Ewing’s sarcoma or chondrosarcoma who had an elevated CRP before their treatment started had a significantly poorer disease-specific survival than patients with a normal CRP (p = 0.02 and p < 0.0001, respectively). Patients with a conventional osteosarcoma and a raised CRP were at an increased risk of poorer local control. We recommend that CRP levels are measured routinely in patients with a suspected sarcoma of bone as a further prognostic indicator of survival. Cite this article: Bone Joint J 2013;95-B:411-18.

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[439]

TÍTULO / TITLE:  - A large extraskeletal chondroma in the hand of an elderly patient—a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hand Surg. 2013;18(1):111-4. doi: 10.1142/S0218810413720088.

            ●● Enlace al texto completo (gratuito o de pago) 1142/S0218810413720088

AUTORES / AUTHORS:  - Ikeda K; Osamura N; Kasashima S

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Kanazawa Medical Center, Kanazawa 920-8650, Japan. ikeikemed@yahoo.co.jp

RESUMEN / SUMMARY:  - This paper examines a case of extraskeletal chondroma in the hand of an 82-year-old female, first noticed about two years ago. Magnetic resonance imaging showed a mass in the carpal tunnel which extended from the wrist to the palm. The tumor was located between the thenar area and the hypothenar area at the palm level. There was no continuity to the carpal bone or radius bone. The entire size of the tumor was 120 mm x 45 mm x 42 mm. Although extraskeletal chondroma is sometimes seen, a large one in the hand is extremely rare. Since the tumor was too large to excise totally because median nerve entrapped it, it was divided into two parts and excised. After the operation, there was no neurological deficit or pain in the median nerve lesion.

 

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[440]

TÍTULO / TITLE:  - Prognostic variables in patients with primary soft tissue sarcoma of the extremity and trunk treated with neoadjuvant radiotherapy or neoadjuvant sequential chemoradiotherapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Radiat Oncol. 2013 Mar 14;8(1):60.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1748-717X-8-60

AUTORES / AUTHORS:  - Bedi M; King DM; Shivakoti M; Wang T; Zambrano EV; Charlson J; Hackbarth D; Neilson J; Whitfield R; Wang D

RESUMEN / SUMMARY:  - BACKGROUND: Neoadjuvant radiotherapy (NRT) is an effective strategy to treat soft tissue sarcomas (STS). However, the role of neoadjuvant chemoradiotherapy (NCRT)  remains to be determined. METHODS: From May 1999 to July 2010, 112 patients with  localized STS of the extremity and trunk who were treated with NRT or NCRT followed by surgery were retrospectively reviewed. Clinical outcomes including overall survival (OS), disease-free survival (DFS), and distant metastasis free survival (DMFS) were calculated using Kaplan-Meier survival analyses. Prognostic  variables were determined by univariate (UVA) and multivariate analyses (MVA). RESULTS: Median follow-up was 37 months. Median RT dose was 50 Gy. Forty-nine patients received NCRT. Overall limb-preservation rate was 99% and local control  was 97%. The estimated 3-year OS, DFS, and DMFS were 86%, 68%, and 72%, respectively. Age was the only variable to predict for OS, DFS and DMFS on UVA. Age >= 70 predicted for poor OS, stage III disease predicted for poor DFS and DMFS, and the addition of chemotherapy predicted for improved DMFS on MVA. CONCLUSIONS: Excellent rates of local control and limb-preservation were observed in patients with primary STS treated with neoadjuvant therapy followed by surgery. Neoadjuvant sequential chemotherapy followed by radiotherapy may be considered for young patients with stage III STS.

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[441]

TÍTULO / TITLE:  - The use of radiation therapy in the management of selected patients with atypical lipomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2013;2013:485483. doi: 10.1155/2013/485483. Epub 2013 Jan 15.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/485483

AUTORES / AUTHORS:  - Kang J; Botros M; Goldberg S; Giraud C; Nielsen GP; Chen YL; Raskin K; Schwab J; Yoon SS; Hornicek FJ; Delaney TF

INSTITUCIÓN / INSTITUTION:  - Harvard Radiation Oncology Program, Boston, MA 02215, USA ; Flushing Radiation Oncology Services, Queens, NY 11354, USA.

RESUMEN / SUMMARY:  - Background and Objectives. Atypical lipomas are uncommon, slow-growing benign tumors. While surgery has been the primary treatment modality, we have managed some patients with radiation (RT) as a component of the treatment and have reported their outcomes in this study. Methods. A retrospective review of all cases of extremity and trunk atypical lipomas in The Sarcoma Database at the study institution was conducted. Results. Thirteen patients were identified. All  patients underwent surgical resection at initial presentation and received pre- or postoperative radiation for subtotal resection (n = 2), local recurrence (n =  8), or progressive disease (n = 3). The median total radiation dose was 50 Gy. Median followup was 65.1 months. All patients treated with RT remained free of disease at the last followup. No grade 3 or higher late toxicity from radiation was observed. No cases of tumor dedifferentiation occurred. Conclusion. For recurrent or residual atypical lipomas, a combination of reexcision and RT can provide long-term local control with acceptable morbidity. For recurrent tumors,  pre-op RT of 50 Gy appears to be an effective and well-tolerated management approach.

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[442]

TÍTULO / TITLE:  - Vulval epithelioid leiomyoma in a pregnant woman.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Obstet Gynaecol. 2013 Feb;33(2):210. doi: 10.3109/01443615.2012.737051.

            ●● Enlace al texto completo (gratuito o de pago) 3109/01443615.2012.737051

AUTORES / AUTHORS:  - Kim HR; Yi BH; Lee HK; Hong HS; Lee MH; Lee HH; Kwak JJ

INSTITUCIÓN / INSTITUTION:  - Departments of Radiology.

 

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[443]

TÍTULO / TITLE:  - Unusual gingival fibromatosis with aggressive periodontitis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Minerva Stomatol. 2013 Jan;62(1-2):89-91.

AUTORES / AUTHORS:  - Agarwel A

INSTITUCIÓN / INSTITUTION:  - Department of Periodontics, Institute of Dental Sciences, Bareilly, India - drashish.aag@gmail.com.

 

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[444]

TÍTULO / TITLE:  - Renal angiomyolipoma rupture.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JBR-BTR. 2012 Nov-Dec;95(6):371.

AUTORES / AUTHORS:  - Lee CH; Chan WP

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Wan Fang Hospital, Taipei Medical University.

 

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[445]

TÍTULO / TITLE:  - Synovial chondrosarcoma arising from synovial chondromatosis of the knee.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JBR-BTR. 2012 Nov-Dec;95(6):360-2.

AUTORES / AUTHORS:  - Yao MS; Chang CM; Chen CL; Chan WP

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

RESUMEN / SUMMARY:  - We report the case of a 51-year-old woman who had suffered from right knee pain and stiffness for 40 years. Her symptoms had gradually worsened over the past 5 years. One year previously, when she first visited our clinic, plain radiographs  and CT scan images had revealed synovial chondromatosis over the right knee. At the current admission, follow-up MRI showed synovial masses around the knee and worsening of endosteal cortical scalloping in the patella, femoral condyle, and tibial plateau. After diagnosis on the basis of frozen sections, the patient had  total excision of the lesions and total knee athroplasty. Histological examination revealed synovial chondromatosis in the joint cavity and grade 1 chondrosarcoma invasion into the adjacent bone. In long-standing synovial chondromatosis, presentation with aggravated symptoms and deterioration on imaging findings should alert clinicians to the potential for malignant change.

 

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[446]

TÍTULO / TITLE:  - A retrospective analysis of 140 patients with giant cell tumor in the extremity:  A multicenter study based on four hospitals in South China.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Epidemiol. 2013 Feb 15. pii: S1877-7821(13)00020-9. doi: 10.1016/j.canep.2013.01.009.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.canep.2013.01.009

AUTORES / AUTHORS:  - Jiang N; Qin CH; Tan CX; Wen SF; Ma YF; Dong F; Diao XC; Zhang P; Yu B

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, PR China. Electronic address: hnxyjn@126.com.

RESUMEN / SUMMARY:  - Background: Update reports are rarely available regarding the bone giant cell tumors (GCTs) in the extremity in Chinese people. The aim of this study was to review the epidemiological characteristics of bone GCT in the extremity based on  the clinical data from four hospitals in South China. Methods: We searched medical electronic records from January 2001 to December 2011 in four hospitals in South China to identify patients with definite diagnosis of extremity GCT. Epidemiological data including gender, tumor site, age at the time of first diagnosis, local recurrence and pulmonary metastasis were collected and analyzed  statistically. Differences between-genders were particularly analyzed regarding first diagnosis age, tumor site, local recurrence and pulmonary metastasis. T-test and Chi-square test were used for continuous and dichotomous variables, respectively. Results: A total of 140 GCT patients (87 males and 53 females) were identified. The gender ratio was 1.64 for a male predominance. GCTs were mostly located around the knee (67 cases). 92 patients were in their 20s to 40s upon first diagnosis. The average age at the time of first diagnosis for all was 30.49 years, 30.76 years for males and 30.06 years for females (P=0.757). GCT recurred  locally in 50 patients (26 males and 24 females) with no gender difference (P=0.065). The average interval from first surgery to local recurrence was 21.42  months. Pulmonary metastasis was found in 11 patients (8 males and 3 females) also with no gender difference (P=0.667). The average interval from first diagnosis to metastasis was 36.45 months. Conclusions: Extremity GCT may have a male predominance in Chinese population and mostly occur at 20-40 years of age and around the knee. Follow-ups for GCT patients should be carried on for at least 3 years after primary surgery according to the average intervals for possible local recurrence and pulmonary metastasis.

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[447]

TÍTULO / TITLE:  - Peripheral blood mononuclear CD133 mRNA levels correlates with response to treatment in patients with gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(2):e55520. doi: 10.1371/journal.pone.0055520. Epub 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0055520

AUTORES / AUTHORS:  - Deng Y; Hassan MM; Mo J; Lin EH

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yatsen University, Guangzhou, China. dengyanh@mail.sysu.edu.cn

RESUMEN / SUMMARY:  - BACKGROUND: CD133 is a marker that identifies/enriches cancer stem cell implicated in tumor initiation. We hypothesize that changes in the CD133 mRNA expression levels and vascular endothelial growth factor (VEGF) may correlate tumor response in GIST. METHODOLOGY/PRINCIPAL FINDINGS: After informed consent, we obtained peripheral blood samples from 24 evaluable patients with gastrointestinal stromal tumors (GIST). There were 7 -paired samples before and after treatment, We measured CD133 mRNA levels by real time RT-PCR method and vascular endothelial growth factor (VEGF) levels by ELISA. All measurements were  done in duplicates in two separate experiments. The treatment resulted in significant reduction of CD133 mRNA expression (p = 0.048) as well as the level of VEGF (p = 0.003). The mean CD133 mRNA levels for GIST patients was 615. We found no correlation between the CD133 mRNA levels and VEGF levels. (p = 0.826).  Logistic regression analysis suggested a relationship between elevated CD133 mRNA levels and fitted probability of eventual progressive disease (PD) and mixed response at 37% for CD133 mRNA of 2.25, and the probability of eventual PD/MR is  84% for a CD133 of 2072 (p = 0.08). CONCLUSIONS/SIGNIFICANCE: CD133 mRNA expression levels in GIST patients measured by real time RT-PCR assay appeared to correlate with tumor response to surgery or imatinib and may be used to predict tumor progression. Additional prospective studies are warranted.

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[448]

TÍTULO / TITLE:  - Effect of lichong decoction on expression of IGF-I and proliferating cell nuclear antigen mRNA in rat model of uterine leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Tradit Chin Med. 2012 Dec;32(4):636-40.

AUTORES / AUTHORS:  - Li D; Zhang Y; Han H; Geng J; Xie X; Zheng J; Wang Y; Zou X

INSTITUCIÓN / INSTITUTION:  - School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China. dududoctor@yahoo.com.cn

RESUMEN / SUMMARY:  - OBJECTIVE: To study the effect of Lichong Decoction (Lichong Decoction for strengthening anti-pathogenic Qi and eliminating blood stasis) on the expression  of insulin-like growth factor-I (IGF-I) and proliferating cell nuclear antigen (PCNA) mRNA in a rat model of uterine leiomyoma. METHODS: Fifty female Wistar rats were randomized into a normal control group, model group, Lichong Decoction  group, Guizhifuling Capsule (Capsule containing Cassia Twig and Poria) group, and Mifepristone group. The uterine leiomyoma model was established by peritoneal injections of exogenous estrogen and progesterone hormone. The ultrastructural changes in cells of rat uterine tissues were observed with transmission electron  microscopy, and the expression of IGF-I and PCNA mRNA was detected by real-time fluorescent quantitative PCR. RESULTS: Following treatment, cells in the Lichong  Decoction group appeared to be arranged normally, the cellular morphology were almost in a normal state, hyperplasia and hypertrophy of the chondriosome was reduced, collagen fibers were arranged in a regular manner, without obvious hyperplasia, and the expression of IGF-I and PCNA mRNA was significantly decreased compared with the model group (P < 0.01). CONCLUSIONS: The effect of Lichong Decoction on uterine leiomyoma is related to its function in reducing the expression of IGF-I and PCNA mRNA.

 

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[449]

TÍTULO / TITLE:  - Epstein-Barr Virus Associated Smooth Muscle Tumors in Post Transplant Pediatric Patients Two Cases of Rare Locations, and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Fetal Pediatr Pathol. 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 3109/15513815.2012.701265

AUTORES / AUTHORS:  - Elawabdeh N; Cone BM; Abramowsky CR; Wrubel DM; Grossniklaus H; Walrath J; Bashir MZ; Shehata BM

INSTITUCIÓN / INSTITUTION:  - Children’s Healthcare of Atlanta, Pathology Laboratory , Atlanta, Georgia , USA.

RESUMEN / SUMMARY:  - Epstein-Barr virus (EBV) may present few or no symptoms in immunocompetent individuals; however, in immunocompromised patients as in the case of AIDS and post-transplant patients, the virus occasionally stimulates neoplastic transformations. Epstein-Barr virus may play a role in the development of smooth  muscle tumors (SMT). In the case of Epstein-Barr associated smooth muscle tumors  (EBV+SMT), the virus is thought to be the leading factor to the tumorigenic pathway. We report two pediatric patients (6 and 13 years old) who underwent liver transplantation and developed EBV+SMT in the colon and orbit. These two cases represent rare locations for this kind of lesion.

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[450]

TÍTULO / TITLE:  - Mutations in the EXT1 and EXT2 genes in Spanish patients with multiple osteochondromas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sci Rep. 2013 Feb 26;3:1346. doi: 10.1038/srep01346.

            ●● Enlace al texto completo (gratuito o de pago) 1038/srep01346

AUTORES / AUTHORS:  - Sarrion P; Sangorrin A; Urreizti R; Delgado A; Artuch R; Martorell L; Armstrong J; Anton J; Torner F; Vilaseca MA; Nevado J; Lapunzina P; Asteggiano CG; Balcells S; Grinberg D

INSTITUCIÓN / INSTITUTION:  - Department of Genetics, Faculty of Biology, Universitat de Barcelona, CIBERER, IBUB, España.

RESUMEN / SUMMARY:  - Multiple osteochondromas is an autosomal dominant skeletal disorder characterized by the formation of multiple cartilage-capped tumours. Two causal genes have been identified, EXT1 and EXT2, which account for 65% and 30% of cases, respectively.  We have undertaken a mutation analysis of the EXT1 and EXT2 genes in 39 unrelated Spanish patients, most of them with moderate phenotype, and looked for genotype-phenotype correlations. We found the mutant allele in 37 patients, 29 in EXT1 and 8 in EXT2. Five of the EXT1 mutations were deletions identified by MLPA. Two cases of mosaicism were documented. We detected a lower number of exostoses in patients with missense mutation versus other kinds of mutations. In conclusion, we found a mutation in EXT1 or in EXT2 in 95% of the Spanish patients. Eighteen of the mutations were novel.

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[451]

TÍTULO / TITLE:  - Results of a phase I dose escalation study of eltrombopag in patients with advanced soft tissue sarcoma receiving doxorubicin and ifosfamide.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - BMC Cancer. 2013 Mar 16;13:121. doi: 10.1186/1471-2407-13-121.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1471-2407-13-121

AUTORES / AUTHORS:  - Chawla SP; Staddon A; Hendifar A; Messam CA; Patwardhan R; Kamel YM

INSTITUCIÓN / INSTITUTION:  - GlaxoSmithKline, 1250 S, Collegeville Road, Collegeville, PA, USA. conrad.a.messam@gsk.com.

RESUMEN / SUMMARY:  - BACKGROUND: The objective of this Phase I dose escalation study was to explore the safety and tolerability of eltrombopag, an oral, nonpeptide, thrombopoietin receptor agonist, in patients with advanced soft tissue sarcoma (STS) and thrombocytopenia due to treatment with doxorubicin and ifosfamide (AI) combination chemotherapy. METHODS: Patients aged 18 or older with histologically  confirmed, locally advanced or metastatic STS were treated with 1 cycle of AI followed by AI with eltrombopag starting at Cycle 2, using 2 different dosing schedules. The study design included an eltrombopag dose escalation phase starting at 75 mg daily to determine the optimal biological dose (OBD). RESULTS:  Eighteen patients were enrolled and 15 received at least 1 dose of chemotherapy;  3 patients withdrew prior to receiving eltrombopag. Seven, 4, and 1 patients received 75 mg, 100 mg, and 150 mg eltrombopag daily, respectively. No dose-limiting toxicities were reported. Due to slow recruitment, the study was closed prior to identifying an OBD. The most common hematologic adverse events (AEs) were thrombocytopenia (80%), neutropenia (73%), and anemia (67%). The most  common nonhematologic AEs were fatigue (53%), alanine aminotransferase increased, constipation, and nausea (47% each). Eleven of 12 patients who received eltrombopag completed at least 2 chemotherapy cycles; all had increased platelet  counts on Day 1 of Cycle 2 (cycle with eltrombopag) compared to Day 1 of Cycle 1  (cycle without eltrombopag). CONCLUSIONS: Although data are limited, safety data  were consistent with the known toxicities of AI combination chemotherapy or the side effect profile of eltrombopag seen in other studies. Available data suggest  a potential pre- and post-chemotherapy dosing scheme for eltrombopag when administered with AI chemotherapy, and support further investigation of eltrombopag treatment in patients with chemotherapy-induced thrombocytopenia.

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[452]

TÍTULO / TITLE:  - Nutritional and Pharmacological Management during Chemotherapy in a Patient with  Propionic Acidaemia and Rhabdomyosarcoma Botryoides.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JIMD Rep. 2012;6:73-8. doi: 10.1007/8904_2012_137. Epub 2012 Mar 21.

            ●● Enlace al texto completo (gratuito o de pago) 1007/8904_2012_137

AUTORES / AUTHORS:  - Martin-Hernandez E; Quijada-Fraile P; Oliveros-Leal L; Garcia-Silva M; Perez-Cerda C; Baro-Fernandez M; Perez-Alonso V; Vivanco J

INSTITUCIÓN / INSTITUTION:  - Unidad Pediatrica de Enfermedades Raras. E. Mitocondriales-Metabolicas Hereditarias. Departamento de Pediatria, Hospital Universitario 12 de Octubre, Madrid, España, emartinh.hdoc@salud.madrid.org.

RESUMEN / SUMMARY:  - We present the nutritional and pharmacological management of a 2-year-old girl with a severe form of propionic acidaemia and a genitourinary embryonal rhabdomyosarcoma. This association has not been described before, nor the utilization of chemotherapy in patients with propionic acidaemia.The patient is a girl with neonatal onset of propionic acidaemia, homozygous for the c.2041-2924del3889 mutation in PCCA gene. At 23 months of age she was diagnosed with genitourinary embryonal rhabdomyosarcoma. Conservative surgery, brachytherapy and nine cycles of chemotherapy with iphosphamide, vincristine and  actinomycin were recommended by oncologists. Due to the possibility that the child could present decompensations, we elaborated three different courses of treatment: when the patient was stable (treatment 1), intermittent bolus feeding  through gastrostomy, containing 70 kcal/kg/day and 1.4 g/kg/day of total protein  (0.6 g/kg/day of natural protein and 0.8 g/kg/day of amino acid-based formula) was prescribed; on the chemotherapy-days (treatment 2), diet consisted on continuous feeding, with the same energy and amino acid-based formula but half of natural protein intake; in case of decompensation (treatment 3), we increased by  10% the energy intake, and completely stopped natural protein in the diet but maintaining the amino acid-based formula. On chemotherapy- days carnitine was increased from 100 mg/kg/day to 150 mg/kg/day, and N-carbamylglutamate was added.Through the 7 months with chemotherapy the patient did not suffer decompensations, while she maintained good nutritional status.Enteral continuous  feeding by gastrostomy, amino acid-based formula, and preventive use of N-carbamylglutamate during chemotherapy-days are the principal measures we propose in these situations.

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[453]

TÍTULO / TITLE:  - Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - BMC Clin Pathol. 2013 Mar 15;13:9. doi: 10.1186/1472-6890-13-9.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1472-6890-13-9

AUTORES / AUTHORS:  - Sorbye SW; Kilvaer TK; Valkov A; Donnem T; Smeland E; Al-Shibli K; Bremnes RM; Busund LT

INSTITUCIÓN / INSTITUTION:  - Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway. sveinung.sorbye@unn.no.

RESUMEN / SUMMARY:  - BACKGROUND: S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and  progesterone receptor (PGR) in soft tissue sarcomas (STS). Skp2 has been demonstrated to display an oncogenic function since its overexpression has been observed in many human cancers. Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant therapy. The  prognostic significance of Skp2 related to ER and PGR in STS has not been sufficiently investigated. METHODS: Tissue microarrays from 193 STS patients were constructed from duplicate cores of viable and representative neoplastic tumor areas. Immunohistochemistry was used to evaluate the expression of Skp2, ER and PGR. RESULTS: In univariate analyses, high tumor expression of Skp2 correlated (p = 0.050) with reduced disease-specific survival (DSS). In subgroup analyses expression of PGR in males (p = 0.010) and in patients older than 60 years (p = 0.043) were negative prognostic factors for DSS. Expression of ER in females was  a positive prognostic factor for DSS (p = 0.041). In co-expression analyses in the whole cohort, low expression of Skp2 in combination with low expression of ER was positive for DSS (p = 0.049). In females high expression of Skp2 in combination with low expression of ER was a negative prognosticator (p = 0.021).  In the multivariate analyses, age (p = 0.012), malignancy grade (p < 0.001), wide resection margins (P = 0.010), ER negative / PGR positive co-expression profile (p = 0.002) and ER positive / PGR negative co-expression profile (p = 0.015) were independent negative prognostic factors for DSS. In females expression of Skp2 (p = 0.006) was associated with shorter DSS. CONCLUSIONS: We found diverse prognostic impacts of expression of Skp2, ER, PGR and DSS in male and female patients with STS. In men, but not women, ER positive / PGR negative co-expression profile was an independent negative prognostic factor for DSS. In women, but not men, high expression of Skp2 was associated with reduced DSS.

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[454]

TÍTULO / TITLE:  - Renal transplant in a tuberous sclerosis patient with bilateral giant renal angiomyolipomas and concurrent renal carcinoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Saudi J Kidney Dis Transpl. 2013 Mar-Apr;24(2):318-21.

AUTORES / AUTHORS:  - Hussain M; Mubarak M; Sultan G; Ahmed E; Yunus M; Salehi MA; Asif M; Anwer Naqvi SA; Rizvi SA

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.

RESUMEN / SUMMARY:  - Co-existence of angiomyolipoma (AML) and renal cell carcinoma (RCC) in the same tumor mass is very rare and only eight cases have been reported. We present a case of a young female with tuberous sclerosis complex (TSC) with bilateral huge  renal AMLs. Both tumors were removed, one of which revealed co-incidental RCC. She was subsequently successfully transplanted a kidney from her brother and is maintaining normal graft function eight months post-transplant. No recurrence or  metastases of RCC has been detected till the last follow-up.

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[455]

TÍTULO / TITLE:  - Giant extragastrointestinal stromal tumor in the transverse mesocolon concomitant with gastric cancer in an elderly patient: Case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Feb;5(2):627-630. Epub 2012 Nov 16.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1030

AUTORES / AUTHORS:  - Xue D; Chen H; Chen Y

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, Qilu Hospital, Shandong University, Jinan 250012,  P.R. China.

RESUMEN / SUMMARY:  - Extragastrointestinal stromal tumors (EGISTs) are neoplasms located outside the gastrointestinal tract in sites including the omentum, mesentery and retroperitoneum. EGISTs of the transverse mesocolon are rarely noted in the literature. Herein, we describe a rare case of giant EGIST concomitant with gastric cancer in a 78-year-old male who presented with upper abdominal pain and  a palpable mass. The patient underwent en bloc resection of the tumor with a distal gastrectomy, with a D2 lymphadenectomy for the gastric cancer, accompanied with resection of a segment of the transverse colon. The patient received targeted therapy (imatinib 400 mg, daily) and adjuvant chemotherapy with FOLFOX (six cycles). Neither recurrence nor metastasis was observed after 24 months of follow-up.

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[456]

TÍTULO / TITLE:  - Low-grade endometrial stromal sarcoma in young age: a clinicopathological report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Obstet Gynaecol India. 2012 Feb;62(1):73-5. doi: 10.1007/s13224-012-0137-9. Epub 2012 Apr 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13224-012-0137-9

AUTORES / AUTHORS:  - Jassal CD; Patnaik BL; Divya A; Prasad S

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110 002 India ; Department of Obstetrics and Gynecology, Saroj Hospital and Heart Institute, Madhuban Chowk, Rohini, New Delhi, 110 085 India ; A1 block, House No. 171A, Lawrence Road, Keshav Puram, Delhi, 110035 India.

 

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[457]

TÍTULO / TITLE:  - Outcome of patients with advanced solitary fibrous tumors: the Centre Leon Berard experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - BMC Cancer. 2013 Mar 11;13(1):109.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1471-2407-13-109

AUTORES / AUTHORS:  - Levard A; Derbel O; Meeus P; Ranchere D; Ray-Coquard I; Blay JY; Cassier PA

RESUMEN / SUMMARY:  - BACKGROUND: Solitary Fibrous Tumor is a rare type of soft tissue tumor of intermediate malignant potential which may recur or metastasize in 15-20% of cases. Data on the management of patients with advanced SFT is scarce: chemotherapy has been described as ineffective, while recent data suggests that anti-angiogenic therapies may be more efficient. METHODS: We conducted a retrospective study on patients treated for advanced SFT at a single institution: from January 1994 to December 2011, 30 patients were treated in the Centre Leon Berard for an advanced SFT. RESULTS: Twenty-three patients received cytotoxic chemotherapy as first-line therapy. Best responses were 2 (9%) partial responses, 13 (57%) stable diseases (SD) and 8 (35%) progressive diseases (PD). Median Progression Free Survival (PFS) was 5.2 (95%CI: 3.2-7.1) months and 9 patients were free of progression at 6 months. Ten patients received an anti-angiogenic treatment (sunitinib or pazopanib) as a 2nd, 3rd or 4th line. Best responses were 5 SD and 5 PD; median PFS was 5.1 months (95%CI 0.7-9.6). Four patients (36%) were progression-free for more than 6 months. Two patients receiving pazopanib were without progression at 6 and 8 months and two patients receiving sunitinib were free of progression at 30 months. CONCLUSION: Response rate with standard chemotherapy was low and PFS appear similar between cytotoxic chemotherapy and anti-angiogenic agents.

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[458]

TÍTULO / TITLE:  - Pseudoangiosarcomatous squamous cell carcinoma in an old surgical scar of an African woman.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Afr J Med Med Sci. 2012 Sep;41(3):317-20.

AUTORES / AUTHORS:  - Olaofe OO; Omoniyi-Esan GO; Omonisi AE; Alakinyoola AL

INSTITUCIÓN / INSTITUTION:  - Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University, Nigeria. rindeolaofe@yahoo.com

RESUMEN / SUMMARY:  - BACKGROUND: Squamous cell carcinoma, a malignant proliferation of keratinocytes,  can be found in many regions of the body covered by stratified squamous epithelium and in areas covered by other epithelia but which had undergone squamous metaplasia. Squamous cell carcinoma has many variants. METHODOLOGY: We,  retrospectively, reviewed the case file and histological features of a 75 year old trader with a rare variant of squamous cell carcinoma arising from an old surgical scar. CASE REPORT: The 75-year-old African female trader presented to the hospital with three and a-half month history of a swelling in the anterior aspect of the left leg arising from an old surgical scar. Clinical examination showed an irregularly shaped ulcer measuring 14 x 16 cm with an everted edge and  a hyperpigmented floor. Histologic sections of the specimen showed the infiltration of the papillary and reticular dermis of the skin by sheets of atypical spindle cells with areas of squamous differentiation. There was a contiguous area of capillary-like structures constituting about 30% of the sections examined. The neoplastic cells were positive for vimentin and cytokeratin but were negative for CD34. The diagnosis was pseudoangiosarcomatous  squamous cell carcinoma. CONCLUSION: This tumour can be found in Africans and in  an old surgical scar. It can coexist with other variants of squamous cell carcinoma. There may be need in the future to add a new mixed variant to the current classification scheme.

 

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[459]

TÍTULO / TITLE:  - Clinical outcomes of giant cell tumor of bone treated with bone cement filling and internal fixation, and oral bisphosphonates.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Feb;5(2):447-451. Epub 2012 Nov 20.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1036

AUTORES / AUTHORS:  - Yu X; Xu M; Xu S; Su Q

INSTITUCIÓN / INSTITUTION:  - Orthopedic Department, General Hospital of Jinan Military Commanding Region, Jinan, Shandong 250031, P.R. China.

RESUMEN / SUMMARY:  - Giant cell tumor (GCT) of the bone is a relatively common primary bone tumor. Treatment with simple curettage often results in a high local recurrence rate. Tumor resection and reconstruction with prosthesis or an allograft has a low rate of local recurrence; however, the patient’s native joint function becomes significantly impaired. With the development and usage of aggressive curettage, it is a priority to treat GCT with a method that reduces the local recurrence rate and preserves the native joint. To evaluate the feasibility of treating GCT  with aggressive curettage and cement filling using internal fixation and oral bisphosphonates, 16 patients with GCT of the bone located in the distal femur and treated in our department from January 2008 to June 2011, were followed up. The patients had received aggressive curettage, bone cement filling, internal fixation and oral administration of bisphosphonates.There were seven males and nine females in total, with a mean age of 38 years. All patients were carefully assessed prior to surgery in order to determine the integrity of the tumor cavity. Subsequently, patients were treated with aggressive curettage by high-speed burring and cementation with internal fixation, and were administered  postoperative oral alendronate sodium tablets (10 mg/day) for two years. The median follow-up time was 25 months. None of the patients were lost to follow-up. No local recurrence or metastasis was observed in the last follow-up. The Enneking limb function score range of the affected limb was 24-29 (average, 26.7). At the last follow-up, all patients exhibited solid fixation without fracture of the subchondral bone in plain radiographs. Based on these data, we suggest that patients with distal femoral GCT may be treated with aggressive curettage and cement filling, with internal fixation and oral bisphosphonates. The advantages of this method are its safety and efficacy. However, the long-term outcomes require further investigation.

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[460]

TÍTULO / TITLE:  - A comparison between patients with gastrointestinal stromal tumours diagnosed with isolated liver metastases and liver metastases plus sarcomatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - HPB (Oxford). 2012 Dec 27. doi: 10.1111/hpb.12011.

            ●● Enlace al texto completo (gratuito o de pago) 1111/hpb.12011

AUTORES / AUTHORS:  - de la Fuente SG; Deneve JL; Parsons CM; Zager JS; Conley AP; Gonzalez RJ

INSTITUCIÓN / INSTITUTION:  - Department of Sarcoma Oncology, Moffitt Cancer Center, Tampa, FL, USA.

RESUMEN / SUMMARY:  - OBJECTIVES: This study was conducted to compare overall survival (OS) in patients presenting with isolated hepatic metastases with that of patients with synchronous metastatic disease to the liver and sarcomatosis on a background of gastrointestinal stromal tumours (GISTs). METHODS: Patients presenting with metastatic GISTs during 1999-2009 were identified. Survival outcomes were compared between groups. RESULTS: Of the 193 patients with GISTs, 43 patients presented with isolated hepatic metastases and 16 presented with synchronous metastases to the liver and sarcomatosis. Thirteen patients with metastases to the liver and sarcomatosis underwent surgery, and 34 patients with metastatic disease solely to the liver underwent hepatic resection. The proportion of patients treated with preoperative tyrosine kinase inhibitor (TKI) therapy was similar in both groups. Similar OS was observed in both groups (isolated liver metastases group: 40.5 months; liver metastases and sarcomatosis group: 28.7 months; P = 0.620). CONCLUSIONS: Overall survival in patients with GIST and metastatic disease to the liver and sarcomatosis is similar to that in patients with isolated metastatic liver disease. Although patients with a greater disease  burden might be expected to show worse survival, these data do not reflect this assumption.

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[461]

TÍTULO / TITLE:  - Osteosarcoma arising on a background of Paget’s disease report of an unusual case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 29;2013. pii: bcr2012007770. doi: 10.1136/bcr-2012-007770.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007770

AUTORES / AUTHORS:  - Qureshi A; Zahid KF; Ibrahim SI; Burney I

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Sultan Qaboos University Hospital, Muscat, Oman. asimqureshi32@hotmail.com

RESUMEN / SUMMARY:  - One of the serious complications of Paget’s disease (PD) is a significant increase in the risk of developing osteosarcoma. Approximately 1% of the patients with PD develop osteosarcoma. This contributes significantly to the mortality and morbidity of the patients with PD. We present the case of an elderly person, who  developed osteosarcoma 1 year after being diagnosed to have PD. The patient had been diagnosed to have lymphoma 8 years prior to the diagnosis of PD. The association between PD and follicular lymphoma is discussed.

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[462]

TÍTULO / TITLE:  - Radical surgery and different types of urinary diversion in patients with rhabdomyosarcoma of bladder or prostate - A single institution experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Urol. 2013 Feb 2. pii: S1477-5131(13)00015-6. doi: 10.1016/j.jpurol.2013.01.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpurol.2013.01.008

AUTORES / AUTHORS:  - Stein R; Frees S; Schroder A; Russo A; Gutjahr P; Faber J; Thuroff JW

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Urology, Department of Urology, University of Mainz, Medical School, Mainz, Germany. Electronic address: Raimund.Stein@unimedizin-mainz.de.

RESUMEN / SUMMARY:  - PURPOSE: In a retrospective study we analyzed the outcome of patients treated for rhabdomyosarcoma (RMS) of the bladder/prostate with special attention to radical  surgery. METHODS: In 25 patients with genitourinary RMS (15 bladder/10 prostate)  the median age at diagnosis was 4 years [1-18], and 8 patients had a stage II RMS, 12 stage III and 5 stage IV. In 19/25 (12 bladder/7 prostate), radical surgery and urinary diversion were performed. Urinary diversion comprised 2 continent anal diversions, 11 continent cutaneous diversions, 4 colon conduits and 2 urethral diversions (2 + 3 years of age). In the younger child with urethral diversion, a cutaneous appendix stoma was additionally constructed in case of inability to void spontaneously. RESULTS: 4/19 patients who underwent radical surgery died of metastatic RMS; 1 patient with neurofibromatosis died of  a secondary tumor. After median follow-up of 132 months (14-420), 14 patients currently have no evidence of disease. 8/14 patients who survived developed 17 complications requiring operative revision. All patients with a continent diversion are continent. The patients with orthotopic bladder substitution are continent day & night and void spontaneously. CONCLUSION: For RMS confined to the bladder or bladder neck, radical cystoprostatectomy and orthotopic bladder substitution are an option. Urethral diversion using the ileocecal segment (Mainz-pouch I) offers the advantage of utilizing the appendix as an additional continent cutaneous stoma, which enables parents to evacuate residual urine in young boys, until able to empty the pouch completely themselves. For all other patients with vital tumor after primary chemotherapy, cutaneous urinary diversion is an option. Long-term complication rates in this complex group of patients are  acceptable.

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[463]

TÍTULO / TITLE:  - Mast cells density in fibrotic capsule of enchondroma and well-differentiated chondrosarcoma: a method for histopathologic differentiation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med J Islam Repub Iran. 2012 Feb;26(1):1-6.

AUTORES / AUTHORS:  - Naderi NJ; Tarabghan SS; Merati M; Ashouri M; Majidi A; Fard MJ

INSTITUCIÓN / INSTITUTION:  - Assistant Professor, Oral and Maxillofacial Pathology Dept, Faculty of Dentistry, Shahed University. Tehran, Iran.

RESUMEN / SUMMARY:  - BACKGROUND: An enchondroma is a benign and a well-differentiated chondrosarcoma is an invasive chondroid tumor with high recurrence potential. In spite of biologic differences, these two tumors have very similar histopathologic appearance. It has been shown that the biologic nature of the connective tissue around benign and malignant tumors varies in the number of mast cells. The aim of this study was to study the histopathologic distinction of enchondroma and well-differentiated chondrosarcoma using the density of the mast cells in fibrotic capsule. METHODS: Twelve enchondroma and 15 well-differentiated chondrosarcoma were collected from Pathology department of Cancer Institute and Central Pathology department of Imam Khomeini Hospital in Tehran. 3 micron paraffin embedded tissue sections were stained by toluidine blue for mast cells counting. Mast cells were counted in fibrous capsule of all cases. Mast cells counts were accomplished in 10 high power fields. The average number of mast cells in 10HPF was determined as an index for each lesion. Mann-Whitney U test was used for statistical analysis. RESULTS: Mean index in enchondroma and well-differentiated chondrosarcoma groups were 0.1+/-0.12 and 0.31+/-0.33 respectively, showing a significant difference between number of mast cells in the fibrotic capsule in these two lesions (p = 0.028). Comparison of the corresponding points in ROC curve, showed a cut-off point = 0.15, with positive predictive value of 61%, negative predictive value 71%, specificity of 33.3% and  sensitivity of 66.7%, (p = 0.025). CONCLUSION: Average density of the mast cells  in the surrounding fibrotic capsules of enchondroma and well-differentiated chondrosarcoma along with other criterions, could be a beneficial factor for histologically differentiation between these two lesions.

 

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[464]

- CASTELLANO -

TÍTULO / TITLE:Doxiciclina em pacientes com linfangioleiomiomatose: biomarcadores e resposta funcional pulmonar.

TÍTULO / TITLE:  - Doxycycline use in patients with lymphangioleiomyomatosis: biomarkers and pulmonary function response.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Bras Pneumol. 2013 Feb;39(1):5-15.

AUTORES / AUTHORS:  - Pimenta SP; Baldi BG; Kairalla RA; Carvalho CR

INSTITUCIÓN / INSTITUTION:  - Hospital A. C. Camargo, Sao Paulo, SP, Brasil.

RESUMEN / SUMMARY:  - OBJECTIVE: To assess blockade of matrix metalloproteinase (MMP)-2 and MMP-9, as well as the variation in FEV1, in patients with lymphangioleiomyomatosis (LAM) treated with doxycycline (a known MMP inhibitor) for 12 months. METHODS: An open-label, single-arm, interventional clinical trial in which LAM patients received doxycycline (100 mg/day) for 12 months. Patients underwent full pulmonary function testing, a six-minute walk test, and quality of life assessment, as well as blood and urine sampling for quantification of MMP-2, MMP-9, and VEGF-D levels-at baseline, as well as at 6 and 12 months after the initiation of doxycycline. RESULTS: Thirty-one LAM patients received doxycycline  for 12 months. Although there was effective blockade of urinary MMP-9 and serum MMP-2 after treatment, there were no significant differences between pre- and post-doxycycline serum levels of MMP-9 and VEGF-D. On the basis of their response to doxycycline (as determined by the variation in FEV1), the patients were divided into two groups: the doxycycline-responder (doxy-R) group (n = 13); and the doxycycline-nonresponder (doxy-NR) group (n = 18). The patients with mild spirometric abnormalities responded better to doxycycline. The most common side effects were mild epigastric pain, nausea, and diarrhea. CONCLUSIONS: In patients with LAM, doxycycline treatment results in effective MMP blockade, as well as in  improved lung function and quality of life in those with less severe disease. However, these benefits do not seem to be related to the MMP blockade, raising the hypothesis that there is a different mechanism of action. (Brazilian Registry of Clinical Trials - ReBEC; identification number RBR-6g8yz9 [ensaiosclinicos.gov.br]).

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[465]

TÍTULO / TITLE:  - 13-year-old tuberous sclerosis patient with renal cell carcinoma associated with  multiple renal angiomyolipomas developing multifocal micronodular pneumocyte hyperplasia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - BMC Clin Pathol. 2013 Feb 5;13:4. doi: 10.1186/1472-6890-13-4.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1472-6890-13-4

AUTORES / AUTHORS:  - Behnes CL; Schutze G; Engelke C; Bremmer F; Gunawan B; Radzun HJ; Schweyer S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, University Medicine Gottingen, Robert-Koch-Str, 40, Gottingen, D-37075, Germany. clbehnes@med.uni-goettingen.de.

RESUMEN / SUMMARY:  - BACKGROUND: The autosomal dominant tumor syndrome tuberous sclerosis complex is caused by the mutated TSC1 gene, hamartin, and the TSC2 gene, tuberin. Patients with this complex develop typical cutaneus symptoms such as peau chagrin or angiofibromas of the skin as well as other lesions such as astrocytomas in the brain and lymphangioleiomyomatosis in the lung. Only a few tuberous sclerosis patients have been described who showed a multifocal micronodular pneumocyte hyperplasia of the lung. Another benign tumor which often occurs together with tuberous sclerosis is the angiomyolipoma of the kidney. Furthermore, an increased incidence of renal cell carcinoma in connection with tuberous sclerosis has also  been proven. CASE PRESENTATION: We report a 13-year-old white girl with epilepsy  and hypopigmented skin lesions. Radiological studies demonstrated the typical cortical tubers leading to the diagnosis of tuberous sclerosis. In the following  examinations a large number of angiomyolipomas were found in both kidneys. One lesion showed an increasing size and tumor like aspects in magnetic resonance imaging. The pathological examination of the following tumorectomy demonstrated an unclassified renal cell carcinoma. Four months postoperatively, a follow-up computer tomography revealed multiple bilateral pulmonary nodules. To exclude lung metastases of the renal cell carcinoma, multiple open-lung biopsies were performed. CONCLUSION: Here we report a diagnostically challenging case of a 13-year-old patient with tuberous sclerosis and angiomyolipomas of the kidney who developed an unclassified renal cell carcinoma as well as multifocal micronodular pneumocyte hyperplasia.

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[466]

TÍTULO / TITLE:  - Uterine carcinosarcoma in a patient with didelphys uterus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Obstet Gynecol. 2013;2013:401962. doi: 10.1155/2013/401962. Epub 2013 Mar 7.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/401962

AUTORES / AUTHORS:  - Iavazzo C; Kokka F; Sahdev A; Singh N; Reynolds K

INSTITUCIÓN / INSTITUTION:  - Gynaecological Department, St Bartholomews Hospital, London EC1A 7BE, UK.

RESUMEN / SUMMARY:  - Background. Didelphys uterus is a noncommon finding in women. Till now, few cases with benign mesenchymal tumors in patients with didelphys uterus are described. We present a case of a patient with carcinosarcoma arising in a didelphys uterus. Case. A 73-year-old patient presented with profuse watery postmenopausal bleeding. On examination under anesthesia, left and right cervixes were identified. Tumor extended from the left cervix into the lower third of the vagina and was adherent to the right vaginal sidewall. There was no evidence of parametrial extension. Tissue was sent for biopsy which revealed high-grade uterine carcinosarcoma. Two uterine fundi and two vaginas in keeping with uterine didelphys were identified on imaging. The patient underwent vaginal excision of the protruding tumor measuring 8 x 6 cm with harmonic scalpel followed by total abdominal hysterectomy and bilateral salpingooophorectomy. Although a number of pelvic and paraaortic lymph nodes were also identified on imaging, she was not planned for lymphadenectomy after MDT (multidisciplinary team) discussion because of her comorbidities. The final histology confirmed the diagnosis. Conclusion. According to our knowledge, this is the second case of carcinosarcoma arising in  didelphys uterus in the world literature.

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[467]

TÍTULO / TITLE:  - Management of a renal calculus larger than 4 cm in a patient with tuberous sclerosis complex-associated angiomyolipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Urol. 2012 Oct;28(4):442-4. doi: 10.4103/0970-1591.105770.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0970-1591.105770

AUTORES / AUTHORS:  - Kodama K; Takase Y; Motoi I

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Toyama City Hospital, Toyama, Japan.

RESUMEN / SUMMARY:  - Renal calculi in patients with renal angiomyolipomas are difficult to treat because of the hemorrhagic potential of these tumors. We describe the case of a 65-year-old man having tuberous sclerosis complex-associated multifocal renal angiomyolipomas with a large renal calculus. The patient presented with left flank dullness and a previous history of spontaneous angiomyolipoma rupture. Intravenous pyelography revealed a 43 x 16 mm calculus in the pelvis and lower calyx of the left kidney. The calculus was successfully removed by retrograde flexible ureterorenoscopy and holmium-YAG lithotripsy. Flexible ureterorenoscopy  is an effective, minimally invasive therapy for patients at high risk of renal hemorrhage.

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[468]

TÍTULO / TITLE:  - Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2013;2013:608964. doi: 10.1155/2013/608964. Epub 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/608964

AUTORES / AUTHORS:  - Cain JE; McCaw A; Jayasekara WS; Rossello FJ; Marini KD; Irving AT; Kansara M; Thomas DM; Ashley DM; Watkins DN

INSTITUCIÓN / INSTITUTION:  - Centre for Cancer Research, Monash Institute of Medical Research, Monash University, 27-31 Wright St, Clayton, VIC 3168, Australia.

RESUMEN / SUMMARY:  - Histone deacetylase inhibitors (HDACi) were identified nearly four decades ago based on their ability to induce cellular differentiation. However, the clinical  development of these compounds as cancer therapies has focused on their capacity  to induce apoptosis in hematologic and lymphoid malignancies, often in combination with conventional cytotoxic agents. In many cases, HDACi doses necessary to induce these effects result in significant toxicity. Since osteosarcoma cells express markers of terminal osteoblast differentiation in response to DNA methyltransferase inhibitors, we reasoned that the epigenetic reprogramming capacity of HDACi might be exploited for therapeutic benefit. Here, we show that continuous exposure of osteosarcoma cells to low concentrations of HDACi LBH589 (Panobinostat) over a three-week period induces terminal osteoblast  differentiation and irreversible senescence without inducing cell death. Remarkably, transcriptional profiling revealed that HDACi therapy initiated gene  signatures characteristic of chondrocyte and adipocyte lineages in addition to marked upregulation of mature osteoblast markers. In a mouse xenograft model, continuous low dose treatment with LBH589 induced a sustained cytostatic response accompanied by induction of mature osteoblast gene expression. These data suggest that the remarkable capacity of osteosarcoma cells to differentiate in response to HDACi therapy could be exploited for therapeutic benefit without inducing systemic toxicity.

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[469]

TÍTULO / TITLE:  - RNA-Dependent Protein Kinase Is Essential for 2-Methoxyestradiol-Induced Autophagy in Osteosarcoma Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(3):e59406. doi: 10.1371/journal.pone.0059406. Epub 2013 Mar 19.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0059406

AUTORES / AUTHORS:  - Yang C; Shogren KL; Goyal R; Bravo D; Yaszemski MJ; Maran A

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, Mayo Clinic, Rochester, Minnesota, United States of America ; Department of Orthopedic, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

RESUMEN / SUMMARY:  - Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Surgical resection and adjunctive chemotherapy are the only widely  available options of treatment for this disease. Anti-tumor compound 2-Methoxyestradiol (2-ME) triggers cell death through the induction of apoptosis  in osteosarcoma cells, but not in normal osteoblasts. In this report, we have investigated whether autophagy plays a role in 2-ME actions on osteosarcoma cells. Transmission electron microscopy imaging shows that 2-ME treatment leads to the accumulation of autophagosomes in human osteosarcoma cells. 2-ME induces the conversion of the microtubule-associated protein LC3-I to LC3-II, a biochemical marker of autophagy that is correlated with the formation of autophagosomes. Conversion to LC3-II is accompanied by protein degradation in 2-ME-treated cells. 2-ME does not induce autophagosome formation in normal primary human osteoblasts. In addition, 2-ME-dependent autophagosome formation in osteosarcoma cells requires ATG7 expression. Furthermore, 2-ME does not induce accumulation of autophagosomes in osteosarcoma cells that express dominant negative mutant RNA-dependent protein kinase (PKR) and are resistant to anti-proliferative and anti-tumor effects of 2-ME. Taken together, our study shows that 2-ME treatment induces PKR-dependent autophagy in osteosarcoma cells,  and that autophagy could play an important role in 2-ME-mediated anti-tumor actions and in the control of osteosarcoma.

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[470]

TÍTULO / TITLE:  - Long-term outcome of giant cell tumor of bone involving sacroiliac joint treated  with selective arterial embolization and curettage: a case report and literature  review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Mar 18;11:72. doi: 10.1186/1477-7819-11-72.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-72

AUTORES / AUTHORS:  - Yu X; Xu M; Xu S; Fu Z

INSTITUCIÓN / INSTITUTION:  - Orthopedic Department, General Hospital of Jinan Military Commanding Region, Jinan, 250031, China. yxch36@yahoo.com.cn.

RESUMEN / SUMMARY:  - BACKGROUND: Giant cell tumor of the sacrum, especially involving the sacroiliac joint, is rare, but is particularly challenging to treat. The long term outcome of a patient was studied with giant cell tumor involving the sacroiliac joint treated with selective arterial embolization and curretage. METHOD: One patient with giant cell tumor involving the sacroiliac joint was treated with selective arterial embolization and curettage in our hospital in October 2002. The curettage and bone grafting was done after two times of selective arterial embolization;1600 ml of blood were transfused and no complications developed during the operation. RESULTS: At the final follow-up of 9 years after the operation, no local recurrence and metastasis developed and she retained normal activity in daily life. CONCLUSION: We think it is an optimal treatment for giant cell tumor involving the sacroiliac joint, with repeated selective arterial embolization and curettage, which has the advantage of less injury, less blood loss and fewer complications.

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[471]

TÍTULO / TITLE:  - Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: An uncommon cause of severe urological disease in an infant.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Urol. 2013 Feb 1. pii: S1477-5131(13)00013-2. doi: 10.1016/j.jpurol.2013.01.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpurol.2013.01.006

AUTORES / AUTHORS:  - Salvitti M; Celestino F; Gerocarni Nappo S; Caione P

INSTITUCIÓN / INSTITUTION:  - Dept. of Urology, Sapienza University, Viale del Policlinico, Rome, Italy. Electronic address: mari.salvitti@gmail.com.

RESUMEN / SUMMARY:  - Neurofibromatosis of the urinary tract occurs infrequently: fewer than 70 cases with bladder involvement have been reported to date and of these, only 25 cases occurred in the pediatric population. We describe an unusual case of plexiform neurofibroma and diffuse ganglioneuromatosis of the bladder in a small infant, diagnosed with neurofibromatosis 1 (NF1) at 3 months of age. At the moment, there are no established criteria for the treatment of this rare lesion. Due to the high morbidity, although not very common, bladder involvement should be considered in infants with NF1.

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[472]

TÍTULO / TITLE:  - Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Immunopathol Pharmacol. 2013 Jan-Mar;26(1):179-88.

AUTORES / AUTHORS:  - Zhang Y; Tang YJ; Man Y; Pan F; Li ZH; Jia LS

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, Zhabei District Central Hospital, Shanghai, China.

RESUMEN / SUMMARY:  - Dysregulation of the Axl receptor tyrosine kinase (RTK) has been implicated in the development and progression of a variety of malignancies. Axl is known to activate strong anti-apoptotic signaling pathways that promote oncogenesis. However, the role of Axl plays in osteosarcoma (OS) remains elusive. The present  study aimed to investigate the clinical significance and function of Axl in human OS. Forty cases of OS and corresponding adjacent non-cancerous tissues (ANCT) were collected. The expression of Axl was assessed using immunohistochemical assay through tissue microarray procedure. A loss-of-function experiment was performed to investigate the effects of small hairpin RNA (shRNA)-mediated knockdown of Axl on the expression of p-AKT, poly ADP-ribose polymerase (PARP) and Ki-67, the proliferative activities, indicated by MTT assay, and the apoptotic index in OS MG-63 cells. As a result, the expression of Axl was found in OS tissues with higher strong reactivity rate, compared with the ANCT (75.0 percent vs 20.0 percent, P=0.000), but it did not associate with the age, gender, tumor size, TNM staging and distant metastases (each Pgreater than0.05). Furthermore, knockdown of Axl inhibited the proliferative activities and induced  apoptosis in MG-63 cells with decreased expression of p-AKT, and Ki-67 and increased expression of PARP. In conclusion, our findings suggest that Axl is highly expressed in most of the OS tissues compared with the ANCT, and knockdown  of Axl inhibits proliferation and induces apoptosis of OS cells possibly through  downregulation of the AKT pathway, suggesting that our findings may provide new insights into the potential therapeutic target for cancer.

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[473]

TÍTULO / TITLE:  - Increased invasiveness of osteosarcoma mesenchymal stem cells induced by bone-morphogenetic protein-2.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - In Vitro Cell Dev Biol Anim. 2013 Mar 22.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11626-013-9598-0

AUTORES / AUTHORS:  - Yang X; Wang YP; Liu FX; Zeng K; Qian MQ; Chen G; Shi L; Zhu GX

INSTITUCIÓN / INSTITUTION:  - Division of Orthopedics, Second People’s hospital of Wuxi, Nanjing Medical University, Wuxi, 214000, People’s Republic of China.

RESUMEN / SUMMARY:  - To evaluate the different traits of mesenchymal stem cell (MSC) isolated from osteosarcoma (OS) and normal bone marrow (BM) induced by bone-morphogenetic protein-2 (BMP-2). MSCs from implanted osteosarcoma or femur bone marrow were isolated and cultured. Differentiation potency was verified and phenotypes were evaluated by flow cytometry. Increased or decreased expressions of BMP-2 were delivered by adenovirus and lentivirus vector, respectively. Expressions of VEGF, EMMPRIN, and MMP-9 were examined. Cell cycle, apoptosis, invasiveness, and proliferation assays were performed between the transfected groups and controls.  Increased BMP-2 induced over-expression of VEGF, EMMPRIN, and MMP-9 in OS- and BM-MSCs both intra- and extra-cellularly. Decreased BMP-2 expression induced inhibition of the factors. Increased BMP-2 also induced less population of cells  at G1 phase, more apoptotic cells, more cells that invade through Transwell membrane, and faster proliferation in OSMSC compared to those in BMMSC. BMP-2 induced higher expression of tumorigenic factors, which could be responsible for  promoting the proliferation and aggressiveness of OSMSC over BMMSC.

 

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[474]

TÍTULO / TITLE:  - Extranodal Rosai-Dorfman disease: a rare soft tissue neoplasm masquerading as a sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Mar 9;11:63. doi: 10.1186/1477-7819-11-63.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-63

AUTORES / AUTHORS:  - Komaragiri M; Sparber LS; Santos-Zabala ML; Dardik M; Chamberlain RS

INSTITUCIÓN / INSTITUTION:  - Saint George’s University School of Medicine, University Centre, Grenada, West Indies. rchamberlain@barnabashealth.org.

RESUMEN / SUMMARY:  - INTRODUCTION: Rosai-Dorfman disease (RDD) is a rare proliferative histiocytic disorder of unknown etiology. RDD typically presents with generalized lymphadenopathy and polymorphic histiocytic infiltration of the lymph node sinuses; however, occurrences of extranodal soft tissue RDD may rarely occur when masquerading as a soft tissue sarcoma. MATERIALS AND METHODS: A comprehensive search of all published cases of soft tissue RDD without associated lymphadenopathy was conducted using PubMed and Google Scholar for the years 1988  to 2011. Ophthalmic RDD was excluded. RESULTS: Thirty-six cases of extranodal soft tissue RDD, including the current one, have been reported since 1988. Anatomical distribution varied among patients. Four (11.1%) patients presented with bilateral lesions in the same anatomic region. Pain was the most common symptom in six (16.8%) patients. Sixteen (41.6%) patients were managed surgically, of which one (2.8%) case experienced recurrence of disease. CONCLUSION: RDD is a rare inflammatory non-neoplastic process that should be considered in the differential diagnosis of a soft tissue tumor. Thus, differentiation of extranodal RDD from more common soft tissue tumors such as soft tissue sarcoma or inflammatory myofibroblastic tumor is often difficult and  typically requires definitive surgical excision with histopathological examination. While the optimal treatment for extranodal RDD remains ill-defined and controversial, surgical excision is typically curative.

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[475]

TÍTULO / TITLE:  - Outcome of Radical Surgery for Pulmonary Metastatic Osteosarcoma with Secondary Spontaneous Pneumothorax: Case Series Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2013 Mar 22.

AUTORES / AUTHORS:  - Nakada T; Okumura S; Kuroda H; Uehara H; Mun M; Sakao Y; Nakagawa K

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgical Oncology, Japanese Foundation for Cancer Research, Cancer Institute Hospital.

RESUMEN / SUMMARY:  - Secondary spontaneous pneumothorax (SSP) caused by malignant tumors is rare, which often makes the choice of treatment difficult. In our hospital, we performed radical surgery for all pulmonary metastases arising from osteosarcoma  (OS) in seven patients with SSP from February 1988 to February 2008 and retrospectively examined the clinicopathological features and postoperative outcomes. The common SSP etiology was tumor tissue rupture at the lung periphery. All patients died of OS recurrence within 18 months. A short disease-free interval (DFI) and a short interval to the second recurrence were the common clinical risk factors of poor prognosis. Curative surgery for pulmonary metastases in OS with SSP is unlikely, but in OS patients with peripheral metastatic lesions that are not accompanied by SSP and have a satisfactory DFI and few lesions, surgical resection should be strongly considered.

 

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[476]

TÍTULO / TITLE:  - Kaposi sarcoma-associated herpesvirus g protein-coupled receptor enhances endothelial cell survival in part by upregulation of bcl-2.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ochsner J. 2013 Spring;13(1):66-75.

AUTORES / AUTHORS:  - Abboud ER; Shelby BD; Angelova M; Nelson AB; Ferris M; McFerrin HE; Morris CA; Sullivan DE

INSTITUCIÓN / INSTITUTION:  - Department of Microbiology and Immunology, Tulane University School of Medicine,  New Orleans, LA.

RESUMEN / SUMMARY:  - BACKGROUND: Kaposi sarcoma-associated herpesvirus (KSHV) encoded G protein-coupled receptor (vGPCR) is a constitutively active lytic phase protein with significant homology to the human interleukin-8 receptor. vGPCR is necessary and sufficient to induce angiogenesis as well as the spindle cell proliferation characteristic of Kaposi sarcoma (KS) lesions. We previously demonstrated that Bcl-2, an antiapoptotic protein, is upregulated in KS lesions. The aim of this study was to determine if vGPCR enhances endothelial cell survival through upregulation of Bcl-2 expression and to elucidate the signaling pathways involved. METHODS: Primary human umbilical vein endothelial cells were transduced with a recombinant retrovirus expressing vGPCR and then subjected to serum starvation. Cell viability and apoptosis were analyzed by fluorescence-activated  cell sorting. Bcl-2 expression was determined by real-time quantitative reverse transcription polymerase chain reaction and immunoblotting. Specific pharmacological inhibitors of phosphatidylinositol 3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) were employed to elucidate the signaling pathways involved. Bcl-2 expression was knocked down using small interfering RNA  (siRNA). RESULTS: Endothelial cells expressing vGPCR showed increased survival after serum starvation and upregulation of Bcl-2 messenger RNA (mRNA) and protein. The vGPCR-induced increases in both Bcl-2 mRNA and protein levels were dependent on PI3K signaling but not on mTOR. Moreover, siRNA inhibition of Bcl-2  resulted in significant abrogation of the observed vGPCR-mediated cell survival advantage. CONCLUSIONS: Taken together, the results demonstrate that Bcl-2 is a mediator of vGPCR-induced endothelial cell survival and is a downstream effector  of Akt in this process.

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[477]

TÍTULO / TITLE:  - Collagen osteoid-like model allows kinetic gene expression studies of non-collagenous proteins in relation with mineral development to understand bone  biomineralization.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(2):e57344. doi: 10.1371/journal.pone.0057344. Epub 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0057344

AUTORES / AUTHORS:  - Silvent J; Nassif N; Helary C; Azais T; Sire JY; Guille MM

INSTITUCIÓN / INSTITUTION:  - UMR 7574, Chimie de la Matiere Condensee de Paris, Ecole Pratique des Hautes Etudes, Universite Pierre et Marie Curie, Paris, France ; UMR 7138, Equipe Evolution et developpement du squelette, Universite Pierre et Marie Curie, Paris, France.

RESUMEN / SUMMARY:  - Among persisting questions on bone calcification, a major one is the link between protein expression and mineral deposition. A cell culture system is here proposed opening new integrative studies on biomineralization, improving our knowledge on  the role played by non-collagenous proteins in bone. This experimental in vitro model consisted in human primary osteoblasts cultured for 60 days at the surface  of a 3D collagen scaffold mimicking an osteoid matrix. Various techniques were used to analyze the results at the cellular and molecular level (adhesion and viability tests, histology and electron microscopy, RT- and qPCR) and to characterize the mineral phase (histological staining, EDX, ATG, SAED and RMN). On long term cultures human bone cells seeded on the osteoid-like matrix displayed a clear osteoblast phenotype as revealed by the osteoblast-like morphology, expression of specific protein such as alkaline phosphatase and expression of eight genes classically considered as osteoblast markers, including BGLAP, COL1A1, and BMP2. Von Kossa and alizarine red allowed us to identify divalent calcium ions at the surface of the matrix, EDX revealed the correct Ca/P ratio, and SAED showed the apatite crystal diffraction pattern. In addition RMN led to the conclusion that contaminant phases were absent and that the hydration  state of the mineral was similar to fresh bone. A temporal correlation was established between quantified gene expression of DMP1 and IBSP, and the presence of hydroxyapatite, confirming the contribution of these proteins to the mineralization process. In parallel a difference was observed in the expression pattern of SPP1 and BGLAP, which questioned their attributed role in the literature. The present model opens new experimental possibilities to study spatio-temporal relations between bone cells, dense collagen scaffolds, NCPs and  hydroxyapatite mineral deposition. It also emphasizes the importance of high collagen density environment in bone cell physiology.

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[478]

TÍTULO / TITLE:  - CT-guided radiofrequency ablation of osteoid osteoma: correlation of clinical outcome and imaging features.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Interv Radiol. 2013 Mar 8. doi: 10.5152/dir.2013.096.

            ●● Enlace al texto completo (gratuito o de pago) 5152/dir.2013.096

AUTORES / AUTHORS:  - Rehnitz C; Sprengel SD; Lehner B; Ludwig K; Omlor G; Merle C; Kauczor HU; Ewerbeck V; Weber MA

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic and Interventional Radiology, University of Heidelberg,  Heidelberg, Germany.

RESUMEN / SUMMARY:  - PURPOSE: We aimed to retrospectively evaluate the computed tomog- raphy (CT) and  magnetic resonance imaging (MRI) findings of patients with osteoid osteoma treated with CT-guided ra- diofrequency ablation (RFA) along with the clinical outcome and long-term success. MATERIALS AND METHODS: Seventy-three CT-guided RFA procedures were performed in 72 patients. The long-term success was assessed using a questionnaire including several visual analog scale scores. The CT evaluation included pre- and immediate postproce- dural imaging of all 72 patients, and MRI was performed in 18 patients with follow-up imaging (mean, 3.4+/-2.2 months). The evaluation criteria included nidus morphology and a cor- relation with markers of clinical success. RESULTS: The primary technique effectiveness rate was 71/72 (99%). One relapse was successfully retreated, leading to a second- ary technique effectiveness rate of 72/72 (100%). The long-  term follow-up (mean, 51.2+/-31.2 months; range, 3-109 months) revealed a highly  significant reduction of all as- sessed limitation scores (P < 0.001). The CT morphology was typical in all cases and did not change during the short-term follow-up. The follow-up MRI patterns varied considerably, in- cluding persistent nidus contrast enhancement in one-third (6/18) and persistent marrow edema in half (9/18) of the patients. None of the investigated MRI and CT patterns cor- related with the clinical outcome. CONCLUSION: The long-term outcome of CT-guided RFA of osteoid oste- oma is excellent. There is no correlation of the CT and MRI  patterns with the clinical outcome. Thus, the treatment de- cisions should not be solely based on the imaging findings. Investigators should also be aware of the variety of imaging patterns after RFA.

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[479]

TÍTULO / TITLE:  - The surprising outcome of a giant primary mediastinal synovial sarcoma treated with neoadjuvant chemotherapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Thorac Dis. 2013 Feb;5(1):94-6. doi: 10.3978/j.issn.2072-1439.2012.12.05.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2072-1439.2012.12.05

AUTORES / AUTHORS:  - Balieiro MA; Lopes AJ; Costa BP; Veras GP; Perelson PS; Acatauassu Nunes R; Saito EH

INSTITUCIÓN / INSTITUTION:  - Division of Thoracic Surgery, State University of Rio de Janeiro, Rio de Janeiro, Brazil;

RESUMEN / SUMMARY:  - There are only a few cases of primary mediastinal synovial sarcoma in the literature. Normally, they do not respond well to chemotherapy. In our case, a 30-year-old patient was admitted due to thoracic pain, dyspnea, orthopnea, cough, hoarseness and weight loss over a 3-month period as well as a dramatic worsening  a week before the admission. A chest radiography showed a completely white left hemithorax and contralateral mediastinal shift; in addition, a chest tomography revealed a giant heterogeneous mediastinal mass, lung atelectasia and a small pleural effusion. The patient was submitted to Chamberlain procedure (biopsy) under local anesthesia and the diagnosis of a synovial sarcoma was obtained after immunohistochemical analysis. Due to his poor general condition, he received chemotherapy first, with a dramatic response, after what, the mass that had been  reduced was removed surgically. After a 5-year- follow-up period there are no signs of disease recurrence.

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[480]

TÍTULO / TITLE:  - Sinonasal rhabdomyosarcoma: prognostic factors and treatment outcomes.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int Forum Allergy Rhinol. 2013 Feb 19. doi: 10.1002/alr.21157.

            ●● Enlace al texto completo (gratuito o de pago) 1002/alr.21157

AUTORES / AUTHORS:  - Thompson CF; Kim BJ; Lai C; Grogan T; Elashoff D; St John MA; Wang MB

INSTITUCIÓN / INSTITUTION:  - Department of Head and Neck Surgery, University of California, Los Angeles, CA.

RESUMEN / SUMMARY:  - BACKGROUND: Despite the improvement in survival of pediatric patients with rhabdomyosarcoma, the outcome of patients with sinonasal rhabdomyosarcoma is poor and has not significantly changed. Since few institutions have extensive experience with sinonasal rhabdomyosarcoma in children and adults, our objective  was to determine prognostic factors and treatment outcomes for this rare malignancy. METHODS: A retrospective review was performed of consecutive patients with sinonasal rhabdomyosarcoma treated at our institution from 1992 to 2012. Kaplan-Meier estimates and the log-rank test were performed to determine factors  associated with disease recurrence and disease-specific survival. RESULTS: Initial remission was achieved in 12 of the 16 patients. Age younger than 18 years (n = 9) was a positive prognostic factor, as there were no recurrences (p < 0.01) and no deaths (p < 0.01). The alveolar subtype was a poor prognostic factor, as 4 of the 5 patients with this histology died of disease (p < 0.01), and both patients with initial remission developed recurrence (p < 0.01). Presentation with later tumor-node-metastasis classification of malignant tumors  (TNM) stage was also significant for poorer survival, as 2 of the 3 patients with stage IV died of disease (p = 0.05). Patient sex and treatment modality were not  significant. CONCLUSION: Although the sinonasal region is an unfavorable site for rhabdomyosarcomas, in our series patients younger than 18 years and those with embryonal or botryoid subtypes responded very well to current multimodality treatment. However, a poor prognostic trend is evident in patients with sinonasal alveolar rhabdomyosarcomas, as they appear to present more often with regional and distant metastases, have increased recurrence, and decreased survival.

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[481]

TÍTULO / TITLE:  - Successful Sleeve Lobectomy of Inflammatory Myofibroblastic Tumor in a 4-year-old Child.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2013 Feb 28.

AUTORES / AUTHORS:  - Pan W; Du L; Wu Y; Cai W

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

RESUMEN / SUMMARY:  - Primary pulmonary tumors in small children have remained a challenge for pediatric surgeons. Pneumonectomy and radical lobectomy are limitedly indicated due to surgical difficulties and sequelae. Here, we present our experience with a 4-year-old patient who suffered from an inflammatory myofibroblastic tumor. A left lower sleeve lobectomy was performed, and the patient recovered significantly after surgery. At the last follow-up, the child was growing well without any sequel, which supports our hypothesis that in small children, sleeve  resection is the preferred treatment for tumors on the main stem bronchus and presents an alternative to an otherwise unavoidable pneumonectomy.

 

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[482]

TÍTULO / TITLE:  - Pediatric gliosarcoma with fibrosarcomatous differentiation: Report of a rare case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Pathol Microbiol. 2012 Oct;55(4):521-4. doi: 10.4103/0377-4929.107797.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0377-4929.107797

AUTORES / AUTHORS:  - Ravisankar S; Chander RV; Devadoss PK

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Institute of Neurology, Madras Medical College, Chennai, India.

RESUMEN / SUMMARY:  - Gliosarcoma is a rare variant of glioblastoma with a biphasic pattern showing glial and mesenchymal differentiation. It is seen in adults during their fifth to sixth decades of life and is extremely rare in children. We report a case of primary gliosarcoma with fibrosarcomatous differentiation in an 11-year-old boy presenting with headache and vomiting. Imaging showed a contrast-enhancing isodense space-occupying lesion with areas of calcification in the right temporoparietal cortex. A total excision was done and, on histopathologic examination, a differential diagnostic consideration of gliosarcoma and teratoma  with malignant transformation was made. After immunohistochemical analysis, a final diagnosis of gliosarcoma with fibrosarcomatous differentiation was then made. Primary gliosarcoma is a very rare tumor in children with a poor prognosis.

 

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[483]

TÍTULO / TITLE:  - The role and clinical significance of YES-associated protein 1 in human osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Immunopathol Pharmacol. 2013 Jan-Mar;26(1):157-67.

AUTORES / AUTHORS:  - Zhang YH; Li B; Shen L; Shen Y; Chen XD

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

RESUMEN / SUMMARY:  - Yes-associated protein 1 (YAP1) is an oncogene that plays multiple roles in the tumorigenesis and progression of many malignances. The present study aimed to investigate the clinical significance of YAP1 expression in human osteosarcoma (OS) and explore the molecular mechanisms of YAP1 activity in OS MG-63 cells. The expression of YAP1 was assessed by immunohistochemical assay using a tissue microarray procedure. A loss-of-function approach was used to investigate the effects of small hairpin RNA-mediated knockdown of YAP1 on the expression of RUNX2, CyclinD1, and matrix metalloproteinase-9 (MMP-9) as well as the proliferative activities and invasive potential in OS MG-63 cells (evaluated by MTT and Transwell assays, respectively). The expression of YAP1 protein in OS tissues was significantly higher than that in ANCT, and was closely associated with gender (P = 0.013) and Enneking staging (P = 0.035), but it did not correlate with age, tumor location, or distant metastases of OS patients (P greater than 0.05, each). Knockdown of YAP1 resulted in downregulation of the expression of RUNX2, CyclinD1, and MMP-9 and inhibited the proliferation and invasion of MG-63 cells. Our findings suggest that YAP1 is highly expressed in OS tissues, and increased expression of this molecule is correlated with the gender  and Enneking staging of osteosarcoma patients. Knockdown of YAP1 may inhibit the  proliferation and invasion of OS cells through downregulation of the RUNX2 pathway, thereby representing a potential therapeutic target for the treatment of cancer.

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[484]

TÍTULO / TITLE:  - Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Target Oncol. 2013 Feb 21.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11523-013-0267-8

AUTORES / AUTHORS:  - Sikaria S; Heim-Hall J; Diaz EH; Williams R; Sankhala K; Laabs B; Mita M

INSTITUCIÓN / INSTITUTION:  - Experimental Therapeutics Program, Samuel Oschin Comprehensive Cancer Institute,  Cedars-Sinai Medical Center, SCCT Mezzanine MS 35, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.

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[485]

TÍTULO / TITLE:  - ATF4 Promotes beta-Catenin Expression and Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Biol Sci. 2013;9(3):256-66. doi: 10.7150/ijbs.5898. Epub 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 7150/ijbs.5898

AUTORES / AUTHORS:  - Yu S; Zhu K; Lai Y; Zhao Z; Fan J; Im HJ; Chen D; Xiao G

INSTITUCIÓN / INSTITUTION:  - 1. Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA.

RESUMEN / SUMMARY:  - Bone marrow mesenchymal stem cells (MSCs) can differentiate into multiple cell types including osteoblasts. How this differentiation process is controlled, however, is not completely understood. Here we show that activating transcription factor 4 (ATF4) plays a critical role in promoting bone marrow MSC differentiation towards the osteoblast lineage. Ablation of the Atf4 gene blocked the formation of osteoprogenitors and inhibited osteoblast differentiation without affecting the expansion and formation of MSCs in bone marrow cultures. Loss of ATF4 dramatically reduced the level of beta-catenin protein in MSCs in vitro and in osteoblasts/osteoprogenitors located on trabecular and calvarial surfaces. Loss of ATF4 did not decrease the expression of major canonical Wnt/beta-catenin signaling components such as Wnt3a, Wnt7b, Wnt10b, Lrp5, and Lrp6 in MSCs. Furthermore, shRNA knockdown of ATF4 expression decreased the level of beta-catenin protein in MC-4 preosteoblasts. In contrast, overexpression of ATF4 increased beta-catenin protein levels in MC-4 cells. Finally, ATF4 and beta-catenin formed a protein-protein complex in COS-7 cells coexpressing both factors or in MC-4 preosteoblastic cells. This study establishes a new role of ATF4 in controlling the beta-catenin protein levels and MSC differentiation towards the osteoblast lineage.

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[486]

TÍTULO / TITLE:  - Diffuse leiomyomatosis of the uterus diagnosed during pregnancy with successful vaginal delivery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Pathol Microbiol. 2012 Oct;55(4):585-6. doi: 10.4103/0377-4929.107836.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0377-4929.107836

AUTORES / AUTHORS:  - Agarwal K; Madan NK; Pujani M

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Lady Hardinge Medical College, New Delhi, India.

 

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[487]

TÍTULO / TITLE:  - Cardiac myxoma: sixteen-year experience in Central Chest Institute of Thailand.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Assoc Thai. 2012 Dec;95(12):1509-16.

AUTORES / AUTHORS:  - Porapakkham P; Porapakkham P; Petchyungtong P

INSTITUCIÓN / INSTITUTION:  - Department of Cardiothoracic Surgery, Central Chest Institute of Thailand, Nonthaburi, Thailand. prpkm@yahoo.co.th

RESUMEN / SUMMARY:  - BACKGROUND: Among the rare diseases of primary cardiac tumor myxoma is a leading  pathology. A sixteen-year clinical experience and follow-up ofpatients with surgical removal of this particular mass is reported. MATERIAL AND METHOD: Medical records of intracardiac tumor patients between April 1995 and June 2012 were reviewed and only cardiac myxoma patients who underwent surgical resection were studied The data of clinical presentations, investigations, operative details, and results were analyzed. RESULTS: Forty-five cardiac myxoma patients with a mean age of 52.6 +/- 2.3 (14 to 82) years were on operated during the sixteen-year period; of these, 76% were female. Dyspnea was the most common symptom accounting for approximately 78%,followed by heart failure 38%, and stroke 18%. Constitutional symptoms of weight loss, fatigue, and fever were found 33%, 13%, and 11%, respectively. Mean ejection fraction was 62% and the tumor size varied from 1.4 to 10 centimeters in diameter Site distribution of tumors were left atrium (89%), right atrium (9%), and multiple site (2%), with the interatrial septum as the most frequent site of attachment (69%). Patients with irregular surface tumors had 29% greater chance of having stroke than those with  smooth surface tumors (p = 0.015). There was no operative or post-operative mortality. The complete follow-up was 98% with 99.8 +/- 52 months of mean follow-up. Ten and fifteen-year survival were 97%. A recurrence was found in one  patient with multiple site tumors at eight-year follow-up. CONCLUSION: Myxoma is  a rare disease with a variety of clinical presentation. Surgical resection provides excellent operative and long-term survival. Despite a very insignificant chance of recurrence, long-term follow-up is still necessary.

 

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[488]

TÍTULO / TITLE:  - Cytotoxic T-Lymphocyte Antigen-4 Genetic Variants and Risk of Ewing’s Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genet Test Mol Biomarkers. 2013 Mar 12.

            ●● Enlace al texto completo (gratuito o de pago) 1089/gtmb.2012.0488

AUTORES / AUTHORS:  - Feng D; Yang X; Li S; Liu T; Wu Z; Song Y; Wang J; Gao W; Huang Q; Huang W; Zheng W; Xiao J

INSTITUCIÓN / INSTITUTION:  - 1 Spine Center, Changzheng Hospital, Second Military Medical University , Shanghai, China .

RESUMEN / SUMMARY:  - Despite the knowledge of many genetic alterations present in Ewing’s sarcoma (ES), the complexity of this disease precludes placing its biology into a simple  conceptual framework. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) can decrease T-cell activation and attenuate antitumor responses. Polymorphisms in the CTLA-4  gene have been shown to be associated with different diseases. Here, we investigated the association of four CTLA-4 gene polymorphisms, -1661A/G (rs4553808), -318C/T (rs5742909), +49G/A (rs231775), and CT60A/G (rs3087243), with ES in the Chinese population. A total of 308 ES cases and 362 healthy controls were recruited and CTLA-4 polymorphisms were tested by polymerase chain  reaction-restriction fragment length polymorphism. Results showed that frequencies of the CTLA-4 gene +49AA genotype, +49A allele, and GTAG haplotype were significantly increased in ES patients compared to healthy controls (odds ratio [OR]=2.42, 95% confidence interval [CI] 1.43-4.09, p<0.001; OR 1.38, 95% CI 1.11-1.73, p=0.005, and OR=1.46, 95% CI 1.06-2.02, p=0.020, respectively). We further compared CTLA-4 polymorphisms in ES patients based on different clinical  parameters and data revealed that ES patients with metastasis had higher numbers  of the +49AA genotype than those without metastasis (p=0.004). These results indicated that the CTLA-4 polymorphism could be a risk factor for ES and suggested a potential role of CTLA-4 in the metastasis of this malignancy.

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[489]

TÍTULO / TITLE:  - Magnetic Resonance-guided Focused Ultrasound Treatment for Uterine Fibroids: First Study in Indian Women.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Imaging Sci. 2012;2:74. doi: 10.4103/2156-7514.104307. Epub 2012 Dec 4.

            ●● Enlace al texto completo (gratuito o de pago) 4103/2156-7514.104307

AUTORES / AUTHORS:  - Desai SB; Patil AA; Nikam R; Desai AS; Bachhav V

INSTITUCIÓN / INSTITUTION:  - Department of Imaging and Interventional Radiology, Jaslok Hospital and Research  Center, Mumbai, Maharashtra, India.

RESUMEN / SUMMARY:  - OBJECTIVES: To study the results of magnetic resonance-guided focused ultrasound  surgery (MRgFUS) treatment carried out on Indian patients in our Hospital. MATERIALS AND METHODS: Fifty Indian women (mean age = 36.2 +/- 8.3 years) were treated for fibroids as outpatients using the ExAblate MRgFUS system (InSightec). Non-perfused volumes (NPVs) were measured immediately after treatment to calculate the treatment outcomes. A validated symptom-specific questionnaire to record their symptoms prior to treatment and six months following treatment was completed by patients. The size of the fibroids was measured on the day of the treatment and during the 6-month checkup to calculate shrinkage. Adverse events during and following treatment were recorded and monitored. RESULTS: The average  NPV ratio measured after the treatment was 88% +/- 6%, indicative of high ablated fibroid tissue. Prior to treatment, the mean Symptoms Severity Score was 56.9 +/- 4.8 (n = 50), which is indicative of highly symptomatic patients. Six months following treatment, there was an average fibroid shrinkage of 30% +/- 11%, and a significant decrease in the mean score to 28.6 +/- 6.0 (n = 50) (P < 0.001). There were no reports of serious or unexpected adverse events at any point during treatment or during the follow-up period from any of the 50 women treated in the  current study. CONCLUSIONS: The current results obtained after 6 months of treatment corroborated previous data on the safety and efficacy of MRgFUS for treating uterine fibroids. This is the first publication that provides such data  for a large cohort of Indian women.

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[490]

TÍTULO / TITLE:  - p38 MAPK regulates the expression of ether a go-go potassium channel in human osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Radiol Oncol. 2013 Mar;47(1):42-9. doi: 10.2478/v10019-012-0043-x. Epub 2013 Feb  1.

            ●● Enlace al texto completo (gratuito o de pago) 2478/v10019-012-0043-x

AUTORES / AUTHORS:  - Wu X; Zhong D; Lin B; Zhai W; Ding Z; Wu J

INSTITUCIÓN / INSTITUTION:  - Department of Neurology, the Affiliated Southeast Hospital of Xiamen University,  Zhangzhou, China.

RESUMEN / SUMMARY:  - BACKGROUND: The ether a go-go (Eag) channel has been shown to be overexpressed in a variety of cancers. However, the expression and function of Eag in osteosarcoma are poorly understood. In addition, the molecular mechanisms responsible for Eag  overexpression in cancer cells remain unclear. METHODS: The expression of Eag in  human osteosarcoma cell line MG-63 was detected by reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis. The effect of Eag inhibition on MG-63 cell proliferation was assessed in vitro. The effect of short hairpin RNA (shRNA) mediated knockdown of Eag on osteosarcoma growth was evaluated in xenograft model in vivo. The activation of mitogen-activated protein kinase (MAPK) pathway and p53 in MG-63 cells was detected by Western blot analysis. RESULTS: Eag was overexpressed in MG-63 cells. Imipramine or Eag shRNA  significantly suppressed the proliferation of MG-63 cells in vitro and in vivo. MG-63 cell proliferation was specifically inhibited by p38 MAPK inhibitor SB203580 or small interference RNA (siRNA). The inhibition of p38 MAPK activation by SB203580 or siRNA reduced Eag protein level but increased p53 protein level. Moreover, the activation of p53 by nutlin-3 induced cell growth arrest in MG-63 cells and reduced Eag protein level, while the inactivation of p53 by pifithrin-alpha (PFT-alpha) promoted MG-63 cell growth and increased Eag protein  expression. CONCLUSIONS: Eag channel functions as an oncogene to promote the proliferation of human osteosarocma cells. Furthermore, the high expression of Eag in osteosarcoma cells is regulated by p38 MAPK/p53 pathway.

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[491]

TÍTULO / TITLE:  - PET/CT imaging of HIV-negative Kaposi’s sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ir J Med Sci. 2013 Mar 25.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11845-013-0936-8

AUTORES / AUTHORS:  - Sager S; Engin B; Kutlubay Z; Asa S; Sager SG; Gucluer B; Kanmaz B

INSTITUCIÓN / INSTITUTION:  - Department of Nuclear Medicine, Cerrahpasa Medical Faculty, Istanbul University,  Fatih, Istanbul, Turkey, msaitsager@hotmail.com.

 

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[492]

TÍTULO / TITLE:  - What is in N A M E?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Assoc Physicians India. 2012 Aug;60:50-2.

AUTORES / AUTHORS:  - Gupta VK; Das U; Kumar G; Sharma SC; Agarwal N; Jain AK

INSTITUCIÓN / INSTITUTION:  - Department of Medicine, PGIMER, Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi 110001.

RESUMEN / SUMMARY:  - An interesting and rare case of name syndrome is reported here. A young patient presented with stroke (left side hemiperesis due to cardiac embolic stroke) and cutaneous lesions. Further investigations revealed that left atrial myxoma was the cause of cardioembolic stroke. Skin lesions were also present which included, nevi, ephelides and neurofibroma hence diagnosis of “NAME SYNDROME” was made.

 

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[493]

TÍTULO / TITLE:  - Similar Trends in Serum VEGF-D Levels and Kidney Angiomyolipoma Responses with Longer Duration Sirolimus Treatment in Adults with Tuberous Sclerosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(2):e56199. doi: 10.1371/journal.pone.0056199. Epub 2013 Feb 20.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0056199

AUTORES / AUTHORS:  - Malinowska IA; Lee N; Kumar V; Thiele EA; Franz DN; Ashwal S; Sagalowsky A; Dimario FJ Jr; Cutler D; Krueger D; Camposano S; Paolini J; Dabora SL

INSTITUCIÓN / INSTITUTION:  - Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America.

RESUMEN / SUMMARY:  - CONTEXT: We have previously shown that serum VEGF-D is elevated at baseline, correlates with kidney angiomyolipoma size at baseline and 12 months, and decreases with sirolimus treatment in adults with tuberous sclerosis complex (TSC). To further investigate the utility of serum VEGF-D for longer term monitoring of TSC kidney disease, we present VEGF-D level results with 24 month follow-up. OBJECTIVE: To compare 24 month VEGF-D levels in two subgroups of sirolimus treated patients (OFF SIROLIMUS AFTER 12 MONTHS or ON SIROLIMUS AFTER 12 MONTHS). DESIGN AND INTERVENTION(S): Serum VEGF-D was measured in samples collected from subjects enrolled in a phase 2 multicenter trial evaluating sirolimus for the treatment of kidney angiomyolipomas associated with TSC or TSC/LAM. All participants were treated with sirolimus from 0-12 months. During months 12-24, sirolimus was discontinued in one subgroup. The other subgroup was  treated with additional sirolimus. SETTING: Adult TSC participants were recruited from six clinical sites in the United States (comprehensive TSC clinics, 5; urology clinic, 1). PATIENTS: There were 28 TSC patients who completed all 24 months of the study and serum samples were available at 24 months from 18/28 patients. MAIN OUTCOME MEASURE(S): We compared the percent change in VEGF-D levels (baseline to 24 months) in patients from the two treatment subgroups. RESULTS: At 24 months, VEGF-D levels decreased by 67% compared with baseline (to  787+/-426 pg/ml) in the ON SIROLIMUS AFTER 12 MONTHS group versus a 13% decrease  (to 2971+/-4014 pg/ml) in the OFF SIROLIMUS AFTER 12 MONTHS group (p = 0.013, Mann-Whitney test). A similar trend was observed in kidney angiomyolipoma size but not in pulmonary function tests. Conclusions Serum VEGF-D may be useful for monitoring response to treatment with sirolimus and kidney angiomyolipoma size in patients with TSC, but confirmation is needed. TRIAL REGISTRATION: Clinical trials.gov NCT00126672.

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[494]

TÍTULO / TITLE:  - Osteoid osteoma of the acetabular fossa: Five cases treated with percutaneous resection.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orthop Traumatol Surg Res. 2013 Mar 25. pii: S1877-0568(13)00028-5. doi: 10.1016/j.otsr.2013.01.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.otsr.2013.01.006

AUTORES / AUTHORS:  - Raux S; Kohler R; Canterino I; Chotel F; Abelin-Genevois K

INSTITUCIÓN / INSTITUTION:  - Paediatric Orthopaedics Department, Children’s Hospital, Lyon Civilian Hospital Group, Lyon 1 University, Lyon, France.

RESUMEN / SUMMARY:  - BACKGROUND: Osteoid osteoma is a painful benign osteogenic tumour for which the treatment objective is surgical resection of the nidus. The acetabular fossa is an uncommon site of involvement where surgical access can prove challenging. MATERIALS AND METHODS: We report a case-series composed of five patients with osteoid osteoma of the acetabular fossa treated with percutaneous bone resection  and drilling under computed tomography guidance. RESULTS: All five patients had an uneventful postoperative course with immediate pain relief that was sustained  over time. DISCUSSION: The outcomes achieved using our percutaneous technique compare favourably with those of other percutaneous methods, most notably regarding pain relief and patient tolerance of the procedure. CONCLUSION: Percutaneous bone resection and drilling under computed tomography guidance proved effective for the treatment of osteoid osteoma involving the acetabular fossa. LEVEL OF EVIDENCE: Level IV.

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[495]

TÍTULO / TITLE:  - Result of arthroscopic removal of an enchondroma at the talar dome: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Assoc Thai. 2012 Oct;95 Suppl 10:S226-9.

AUTORES / AUTHORS:  - Laoruengthana A; Galassi M; Weerakul S; Assawaboonyadej P; Somran J

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand. artitlao@gmail.com

RESUMEN / SUMMARY:  - Enchondroma is a benign tumor that is generally asymptomatic and rarely found in  the talus. A forty-nine-year-old man, had a chronic left ankle pain which related to moderate to heavy activity. A plain radiograph and magnetic resonance imaging  (MRI) revealed a 1.3 cm benign lobulated intramedullary lesion at the middle 1/3  of medial part of talar dome with sclerotic rim. An arthroscopic intralesional curettage of the ankle joint was performed without bone grafting. Histologic examination was consistent with the diagnosis of an enchondroma. The patient was  asymptomatic and without restriction on his job at 6 months. At 1 year of follow-up, the CT scan and MRI demonstrated no recurrence of the tumor but the defect was not filled up.

 

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[496]

TÍTULO / TITLE:  - Understanding cardiac myxoma recurrence: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Rev Port Cardiol. 2013 Mar;32(3):239-42. doi: 10.1016/j.repc.2012.05.027. Epub 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.repc.2012.05.027

AUTORES / AUTHORS:  - Carvalho MS; Andrade MJ; Abecasis J; Gouveia R; Branco L; Neves JP; Mendes M

INSTITUCIÓN / INSTITUTION:  - Servico de Cardiologia, Hospital de Santa Cruz, Carnaxide, Oeiras, Portugal. Electronic address: mariasalomecarvalho@gmail.com.

RESUMEN / SUMMARY:  - Recurrence of cardiac myxoma is a rare condition, observed in about 3% of patients in sporadic cases, although it is more frequent in familial ones. Several mechanisms have been proposed to explain such recurrence, and the importance of increased vascularization as a facilitating feature is the subject  of debate. The authors report the case of a non-familial right atrial myxoma, unusual for both its histopathology and recurrence.

 

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[497]

TÍTULO / TITLE:  - A case of collision tumor or transdifferentiation between malignant melanoma and  leiomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Pathol Microbiol. 2012 Oct;55(4):538-9. doi: 10.4103/0377-4929.107806.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0377-4929.107806

AUTORES / AUTHORS:  - Ul-Mulk J; Rasmussen H; Breiting L; Siim E

INSTITUCIÓN / INSTITUTION:  - Department of Plastic Surgery and Reconstruction, Herlev University Hospital, Herlev Ringvej 75, Herlev, Copenhagen, Denmark.

RESUMEN / SUMMARY:  - A 73-year-old woman was referred to the hospital due to a pigmented, asymptomatic nevus on her right arm that had changed in size and color. The histopathological  examination showed a superficial spreading malignant melanoma, Clark level III, 2.26 mm in thickness. Two years later, the patient presented a 10 cm rapidly growing mass in her right axilla. The mass in the axilla measured 12.5 9 cm. It revealed a lymph node metastases with a tumor growth composed of two different contiguous morphological and immunohistochemical components, respectively, melanosomes and leiomyosarcoma. The combination of a melanocytic nevus with other tumor of epidermal or adnexal origin has been described before, but still the co-existence of two different neoplasms within a lesion is still uncommon. The most common combination is basal cell carcinoma and melanocytic nevus or one of them together with a seborrheic keratosis. There have also been occasional reports of rhabdomyosarcomatous differentiation. However, mesenchymal differentiation, and in this case leiomysarcoma, with formation of heterologous elements in melanocytic tumor is very rare. Another plausible explanation may be  that malignant melanoma cells could have transdifferentiated into a leiomyosarcomatoid phenotype with resulting metastases of either type. Malignant  melanomas have shown a wide variety of cytological changes and can mimic carcinomas, lymphomas, and sarcomas. Spindle cell melanomas commonly simulate spindle cell carcinomas. It has also been documented that desmoplastic melanomas  can change into fibroblastic, Schwannian, and myofibroblastic differentiation.

 

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[498]

TÍTULO / TITLE:  - A case of alveolar soft part sarcoma of the pleura.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Korean Med Sci. 2013 Feb;28(2):331-5. doi: 10.3346/jkms.2013.28.2.331. Epub 2013 Jan 29.

            ●● Enlace al texto completo (gratuito o de pago) 3346/jkms.2013.28.2.331

AUTORES / AUTHORS:  - Ju HU; Seo KW; Jegal Y; Ahn JJ; Lee YJ; Kim YM; Oak C; Ra SW

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan,  Korea.

RESUMEN / SUMMARY:  - Alveolar soft part sarcoma (ASPS) is a rare malignant soft-tissue neoplasm of unknown histogenesis. The two main sites of occurrence are the lower extremities  in adults and the head and neck in children. We report the first case of pleural  ASPS occurring in a 58-yr-old man who presented with progressive dyspnea. A computed tomographic scan of the thorax revealed a large enhancing pleural mass with pleural effusion in the left hemithorax. Wide excision of the pleural mass was performed. Histologically, the tumor consisted of organoid nests of large polygonal cells, the cytoplasm of which had eosinophilic and D-PAS positive granules. Immunohistochemical staining showed that the tumor cell nuclei were positive for transcription factor 3 (TFE3). The pleural ASPS with multiple bone metastases recurred 1 yr after surgery and the patient died of acute pulmonary embolism 1.5 yr after diagnosis.

 

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[499]

TÍTULO / TITLE:  - A Case of Rapidly Growing Osteosarcoma of the Rib.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2013 Jan 31.

AUTORES / AUTHORS:  - Ikeda H; Takeo M; Kayata H; Mikami R; Nakamoto Y; Yamamoto M

INSTITUCIÓN / INSTITUTION:  - Kobe City Hospital Organization Kobe City Center West Hospital, Kobe, Hyogo, Japan.

RESUMEN / SUMMARY:  - A 37-year-old woman noticed a right anterior chest mass and pain. The mass had been rapidly growing and she visited our hospital. The mass was hard and 8 x 7 cm in size. It was detected in the upper inner quadrant of her anterior chest wall.  A computed tomography (CT) examination and magnetic resonance imaging (MRI) of the chest revealed a large heterogeneously enhanced mass arising from the right chest wall with lytic destruction of the rib and coarse calcification. An image diagnosis of osteogenic sarcoma originating from a rib was made. She underwent surgical excision of the tumor and chest wall reconstruction. Microscopic examination of the resected tumor showed multiple neoplastic cells accompanied by osteoid formation within the tumor. The tumor was diagnosed as high-grade malignant osteosarcoma of the rib. Primary osteosarcoma commonly originates in the long bone in children and adolescents, but it occurs very rarely in the ribs  in adults. Surgical resection plays an important role in the treatment for this disease. We report a case of primary osteosarcoma that originated in the rib of a young woman and was treated successfully by surgery.

 

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[500]

TÍTULO / TITLE:  - Huge Solitary Fibrous Tumor of the Pleura with Hypoglycemia and Hypokalemia: A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2013 Jan 31.

AUTORES / AUTHORS:  - Li Z; Wang J; Zhu Q; Li H; Chen Y; Chen L

INSTITUCIÓN / INSTITUTION:  - Department of Cardiothoracic Surgery, the First Affiliated Hospi tal of Nanjing Medical University, Nanjing, China.

RESUMEN / SUMMARY:  - The occurrence of hypoglycemia with an intrathoracic tumor is referred to as Doege- Potter syndrome (DPS). However, the association between hypokalemia and DPS is rare. We report a case of a solitary fibrous tumor of the pleura with refractory hypoglycemia and hypokalemia. A 57-year-old male was admitted to our hospital for unconsciousness. His serum glucose and potassium levels were low. Radiological findings revealed a large tumor occupying the left hemithorax. Despite being treated with glucose and potassium replacement therapy, the patient still suffered from repetitive fasting hypoglycemic and hypokalemia episodes. After the tumor was completely resected, his serum levels of glucose and potassium returned to normal level.

 

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[501]

TÍTULO / TITLE:  - Thyroid synovial sarcoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Med Iran. 2013 Jan;51(1):69-72.

AUTORES / AUTHORS:  - Ghafouri A; Anbara T; Mir A; Lashkari M; Nazari M

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Iran.

RESUMEN / SUMMARY:  - Sarcomas are rare tumors account for about 1% of cancers in adult. Soft tissue sarcomas are the most common one. Synovial sarcoma’s incident is about 10% of all sarcomas and most commonly rise from para-articular regions in young adults. Based on our knowledge there have been only two reports of thyroid synovial sarcoma in medical literature. We report a 44-year old woman presented with a rapid growing neck mass. The pathology report revealed sarcoma and the immunohistochemistry (IHC) was compatible with synovial sarcoma. It could be understood that synovial sarcoma can be found in various tissues even if there is no synovial cells.

 

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[502]

TÍTULO / TITLE:  - Osteoid osteoma of a scapula: a case report in a 34 years old woman.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med J Islam Repub Iran. 2012 Aug;26(3):143-6.

AUTORES / AUTHORS:  - Pourfeizi HH; Sales JG; Elmi A; Tabrizi A

INSTITUCIÓN / INSTITUTION:  - Associate Professor of Orthopedics, Orthopedics Department, Tabriz Medical University, Tabriz, Iran. hojjat.pourfeizi@gmail.com.

RESUMEN / SUMMARY:  - Osteoid osteoma is a benign bone tumor and accounts for 10% of benign tumors. Almost any bones can be involved but half of cases involving femur or tibia. Osteoid osteoma is a rare tumor of the scapula with only 18 reported cases in the literature. We presented a case of osteoid osteoma of the scapula in right shoulder in angle of coracoid and geloneid in a 34- year old woman. She had right radicular shoulder pain increased at night for 4 years. An important point about  this case is that, patient was treated in long-term with miss diagnosis of cervicospinal discopathy. The key of diagnosis in this patient was paying attention to the nature of night increasing pain and performing bone scan. After  the operative curettage of the tumor, the pain dramatically stopped and a few weeks of physical therapy led to full range of motion in her shoulder.

 

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[503]

TÍTULO / TITLE:  - Misdiagnosis of a large uterine vein thrombosis as a uterine myoma prior to hysterectomy: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Acad Med Singapore. 2013 Feb;42(2):88-90.

AUTORES / AUTHORS:  - Hoh JK; Lee WM; Lee HJ; Hwang JH

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul, Korea.

 

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[504]

TÍTULO / TITLE:  - Embryonal rhabdomyosarcoma arising from a mediastinal teratoma: an unusual case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Korean Med Sci. 2013 Mar;28(3):476-9. doi: 10.3346/jkms.2013.28.3.476. Epub 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 3346/jkms.2013.28.3.476

AUTORES / AUTHORS:  - Ryu YJ; Yoo SH; Jung MJ; Jang S; Cho KJ

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ; Laboratory of Veterinary Theriogenology, Seoul National University College of Veterinary Medicine, Seoul, Korea.

RESUMEN / SUMMARY:  - We report an unusual case of 9.5-cm-sized embryonal rhabdomyosarcoma arose from a mediastinal mature teratoma in a 46-yr-old man. A man presented with chest trauma as a result of an accident at 10 September 2011. On chest X-ray, an anterior mediastinal mass was detected. To obtain further information, chest computed tomography (CT) with contrast enhancement was performed, revealing an anterior mediastinal mass. Complete surgical excision was performed and entire specimen was evaluated. Pathologic diagnosis was embryonal rhabdomyosarcoma arising in mature cystic teratoma. After surgical excision, two cycles of dactinomycin-based chemotherapy were performed. Lung metastasis was detected on follow up CT in September 2012, and wedge resection was performed. Pathological finding of the lung lesion showed same feature with that of primary rhabdomyosarcoma.

 

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[505]

TÍTULO / TITLE:  - Chondrosarcoma in childhood: the radiologic and clinical conundrum.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Radiol Case Rep. 2012 Dec;6(12):32-42. doi: 10.3941/jrcr.v6i12.1241. Epub 2012  Dec 1.

            ●● Enlace al texto completo (gratuito o de pago) 3941/jrcr.v6i12.1241

AUTORES / AUTHORS:  - Mosier SM; Patel T; Strenge K; Mosier AD

INSTITUCIÓN / INSTITUTION:  - Department of Pediatrics, Ireland Army Community Hospital, Fort Knox, KY, USA.

RESUMEN / SUMMARY:  - Less than 10% of chondrosarcomas occur in children. In addition, as little as 0.5% of low-grade chondrosarcomas arise secondarily from benign chondroid lesions. The presence of focal pain is often used to crudely distinguish a chondrosarcoma (which is usually managed with wide surgical excision), from a benign chondroid lesion (which can be followed by clinical exams and imaging surveillance). Given the difficulty of localizing pain in the pediatric population, initial radiology findings and short-interval follow-up, both imaging and clinical, are critical to accurately differentiate a chondrosarcoma from a benign chondroid lesion. To our knowledge, no case in the literature discusses a  chondrosarcoma possibly arising secondarily from an enchondroma in a pediatric patient. We present a clinicopathologic and radiology review of conventional chondrosarcomas. We also attempt to further the understanding of how to manage a  chondroid lesion in the pediatric patient with only vague or bilateral complaints of pain.

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[506]

TÍTULO / TITLE:  - Cyclin-Dependent Kinase 4 Phosphorylates and Positively Regulates PAX3-FOXO1 in Human Alveolar Rhabdomyosarcoma Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(2):e58193. doi: 10.1371/journal.pone.0058193. Epub 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0058193

AUTORES / AUTHORS:  - Liu L; Wu J; Ong SS; Chen T

INSTITUCIÓN / INSTITUTION:  - Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America.

RESUMEN / SUMMARY:  - Alveolar rhabdomyosarcoma (ARMS) is an aggressive childhood muscle sarcoma with a 5-year survival rate of less than 30%. More than 80% of ARMSs harbor a PAX3-FOXO1 fusion transcription factor. However, expression of PAX3-FOXO1 in muscle cells alone is not sufficient and requires the loss of function of Ink4a/ARF to promote malignant proliferation of muscle cells in vitro or initiate ARMS tumor formation in vivo. This prompted us to examine the signaling pathways required to activate  the function of PAX3-FOXO1 and to explore the functional interaction between the  Ink4a/ARF and PAX3-FOXO1 signaling pathways. Here we report that inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin (a small molecule selective inhibitor of Cdk4/cyclin D1 that we identified in a screen for compounds that inhibit PAX3-FOXO1) led to inhibition of the transcriptional activity of PAX3-FOXO1 in ARMS cell line Rh30. Consistent with this finding, activation of Cdk4 enhanced the activity of PAX3-FOXO1. In vitro kinase assays revealed that Cdk4 directly phosphorylated PAX3-FOXO1 at Ser(430). Whereas fascaplysin did not  affect the protein level of PAX3-FOXO1, it did increase the cytoplasmic level of  PAX3-FOXO1 in a portion of cells. Our findings indicate that Cdk4 phosphorylates  and positively regulates PAX3-FOXO1 and suggest that inhibition of Cdk4 activity  should be explored as a promising avenue for developing therapy for ARMS.

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[507]

TÍTULO / TITLE:  - Digestive tract hemorrhage due to complications with gastrointestinal stromal tumor treated with sunitinib: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Feb;5(2):699-701. Epub 2012 Nov 28.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1050

AUTORES / AUTHORS:  - Liu Y; Zhang HL; Zhang Y; Mei JZ; Lin HW; Guo YW; Li RJ; Meng XR; Liu GJ; Li M; Xiao P; Bai H

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, Zhengzhou People’s Hospital, Southern Medical University, Zhengzhou, Henan 450003;

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs) are rare, and account for 1% of all gastrointestinal neoplasms. GISTs are the most frequent mesenchymal tumors of the gastrointestinal tract. However, the clinical and pathological characteristics of these neoplasms are not adequately understood. The best treatment approach for GISTs remains unclear. In the present study, we report a case of a GIST originating from the stomach. A digestive tract hemorrhage occurred as a complication of sunitinib treatment. This is the first report of a digestive tract hemorrhage due to sunitinib treatment.

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[508]

TÍTULO / TITLE:  - Interstitial laser photocoagulation for the treatment of osteoid osteoma: Retrospective study on 35 cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Interv Imaging. 2013 Mar;94(3):300-10. doi: 10.1016/j.diii.2012.11.002. Epub 2013 Feb 14.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.diii.2012.11.002

AUTORES / AUTHORS:  - Etienne A; Waynberger E; Druon J

INSTITUCIÓN / INSTITUTION:  - CHU de Tours, Hopital Trousseau, Radiology Department, avenue de la Republique, 37170 Chambray-les-Tours, France. Electronic address: amelie_etienne@yahoo.fr.

RESUMEN / SUMMARY:  - PURPOSE: The aim of our retrospective study was to evaluate the efficacy of interstitial laser photocoagulation for the treatment of osteoid osteomas and to  identify the factors leading to failure of the procedure. MATERIAL AND METHODS: Thirty-five patients received interstitial laser photocoagulation treatment. A minimum of 3months follow-up was required. The laser fibre was positioned within  the nidus under CT guidance, and energy between 500 and 1800J was delivered at a  power of 2 Watts/s. Follow-up was by outpatient appointment and through a questionnaire sent to the patients. RESULTS: Thirty patients replied to the questionnaire. Mean follow-up was 40months. The technical success rate was 100%.  The primary success rate (no pain at 1month) was 94.3%. The rate of recurrence was 6%. The rate of complications was 11.4% (a skin burn, patellar enthesopathy,  a broken item of material, sacro-iliac fibrous alterations). Factors likely to favour failure of the procedure are the size of the nidus (P=0.04) and poor positioning of the laser fibre (P=0.03). CONCLUSION: Interstitial laser photocoagulation is an effective and safe treatment for osteoid osteomas.

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[509]

TÍTULO / TITLE:  - Fibrous dysplasia; confirmation of clinical diagnosis by DNA tests instead of biopsy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Musculoskelet Neuronal Interact. 2013 Mar;13(1):120-3.

AUTORES / AUTHORS:  - Stathopoulos IP; Balanika AP; Baltas CS; Lampropoulou-Adamidou K; Koromila T; Kollia P; Tournis S; Papaioannou NA; Katsalira A

INSTITUCIÓN / INSTITUTION:  - Laboratory for the Research of the Musculoskeletal System “Theodoros Garofalidis”, University of Athens, KAT hospital, Athens, Greece.

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[510]

TÍTULO / TITLE:  - Nasal congenital fibrolipomatous hamartoma in a premature infant.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Turk J Pediatr. 2012 Sep-Oct;54(5):555-7.

AUTORES / AUTHORS:  - Oncel MY; Ozdemir R; Yurttutan S; Erdeve O; Akyol U; Tanas O; Dilmen U

INSTITUCIÓN / INSTITUTION:  - Division of Neonatology, Zekai Tahir Burak Maternity Training Hospital, Turkey. dryekta@gmail.com

RESUMEN / SUMMARY:  - Hamartomas are tumor-like lesions composed of tissue elements normally found at the site where they are located, but which grow in a disorganized manner. They generally occur at birth or soon after, although presentations during adult life  have been reported. Hamartomas of the head and neck are very rare. The exact mechanisms behind the development of hamartomas remain unknown; however, their benign nature renders complete surgical excision sufficient for their management. Here, we describe a case of a premature infant with a hamartomatous polypoid lesion containing both fibrous and adipose components, originating from the dorsum of the nose. The differential diagnosis and management of hamartomas of the head and neck are also discussed. Although several cases series on precalcaneal fibrolipomatous hamartomas have been encountered in the literature,  to the best of our knowledge, this is the first report of a nasally located congenital fibrolipomatous hamartoma.

 

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[511]

TÍTULO / TITLE:  - Limited resection for duodenal gastrointestinal stromal tumors: Surgical management and clinical outcome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastrointest Surg. 2013 Feb 27;5(2):16-21. doi: 10.4240/wjgs.v5.i2.16.

            ●● Enlace al texto completo (gratuito o de pago) 4240/wjgs.v5.i2.16

AUTORES / AUTHORS:  - Hoeppner J; Kulemann B; Marjanovic G; Bronsert P; Hopt UT

INSTITUCIÓN / INSTITUTION:  - Jens Hoeppner, Birte Kulemann, Goran Marjanovic, Ulrich Theodor Hopt, Department  of General Surgery, University of Freiburg, 79106 Freiburg, Germany.

RESUMEN / SUMMARY:  - AIM: To analyze our experience in patients with duodenal gastrointestinal stromal tumors (GIST) and review the appropriate surgical approach. METHODS: We retrospectively reviewed the medical records of all patients with duodenal GIST surgically treated at our medical institution between 2002 and 2011. Patient files, operative reports, radiological charts and pathology were analyzed. For surgical therapy open and laparoscopic wedge resections and segmental resections  were performed for limited resection (LR). For extended resection pancreatoduodenectomy was performed. Age, gender, clinical symptoms of the tumor, anatomical localization, tumor size, mitotic count, type of resection resectional status, neoadjuvant therapy, adjuvant therapy, risk classification and follow-up  details were investigated in this retrospective study. RESULTS: Nine patients (5  males/4 females) with a median age of 58 years were surgically treated. The median follow-up period was 45 mo (range 6-111 mo). The initial symptom in 6 of 9 patients was gastrointestinal bleeding (67%). Tumors were found in all four parts of the duodenum, but were predominantly located in the first and second part of the duodenum with each 3 of 9 patients (33%). Two patients received neoadjuvant medical treatment with 400 mg imatinib per day for 12 wk before resection. In one patient, the GIST resection was done by pancreatoduodenectomy. The 8 LRs included a segmental resection of pars 4 of the duodenum, 5 wedge resections with primary  closure and a wedge resection with luminal closure by Roux-Y duodeno-jejunostomy. One of these LRs was done minimally invasive; seven were done in open fashion. The median diameter of the tumors was 54 mm (14-110 mm). Using the Fletcher classification scheme, 3/9 (33%) tumors had high risk, 1/9 (11%) had intermediate risk, 4/9 (44%) had low risk, and 1/9 (11%) had very low risk for aggressive behaviour. Seven resections showed microscopically negative transsection margins  (R0), two showed positive margins (R1). No patient developed local recurrence during follow-up. The one patient who underwent pancreatoduodenectomy died due to progressive disease with hepatic metastasis but without evidence of local recurrence. Another patient died in complete remission due to cardiac disease. Seven of the nine patients are alive disease-free. CONCLUSION: In patients with duodenal GIST, limited surgical resection with microscopically negative margins,  but also with microscopically positive margins, lead to very good local and systemic disease-free survival.

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[512]

TÍTULO / TITLE:  - Giant juvenile fibroadenoma: A case and review of novel modalities in treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Breast Dis. 2013 Feb 26.

            ●● Enlace al texto completo (gratuito o de pago) 3233/BD-130342

AUTORES / AUTHORS:  - Sosin M; Feldman E

INSTITUCIÓN / INSTITUTION:  - Georgetown University Hospital, Department of General Surgery, Washington, DC, USA.

RESUMEN / SUMMARY:  - A giant juvenile fibroadenoma is defined as a fibroadenoma greater than 5 centimeters in size occurring in the pediatric population. It frequently affects  adolescents. Rapid growth of the mass may result in breast asymmetry and deformity. Varying techniques in surgical extirpation have been described in order to optimize aesthetics and minimize distortion. The advent of new methods to remove benign breast disease is in its infancy stages. Many practitioners are  unaware of the novel options that are emerging in the treatment of fibroadenoma.  We describe an excision of a 12 centimeter giant juvenile fibroadenoma and adjacent juvenile fibroadenoma using a strategically atypical incision that resulted in excellent cosmesis and contour of the breast without subsequent reconstruction. Multiple modalities of removing a fibroadenoma are described with a review of the associated risks, benefits, and long term implications as well as a discussion on the indication for reconstructive surgery in patients with giant  juvenile fibroadenoma.

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[513]

TÍTULO / TITLE:  - Angiomyolipoma with minimal fat: differentiation from renal cell carcinoma at helical CT.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chin Med J (Engl). 2013 Mar;126(5):991-2.

AUTORES / AUTHORS:  - Zhao XJ; Pu JX; Ping JG; Zang J; Lu Y; Xi QL; Hou WJ

INSTITUCIÓN / INSTITUTION:  - Department of Urology, First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215006, China.

 

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[514]

TÍTULO / TITLE:  - Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncotarget. 2013 Mar 19.

AUTORES / AUTHORS:  - Yan S; Li Z; Thiele CJ

INSTITUCIÓN / INSTITUTION:  - Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer  Research, National Cancer Institute.

RESUMEN / SUMMARY:  - The IL-6/JAK/STAT pathway is a key signal transduction pathway implicated in the  pathogenesis of many human cancers, suggesting that kinase inhibitors targeting JAK/STAT3 may have a broad spectrum of antitumor activity. AZD1480, a pharmacological JAK1/2 inhibitor, exhibits anti-tumor potency in multiple adult malignancies. To evaluate the efficacy of inhibition of JAK/STAT3 signal transduction pathway we assessed the activity of AZD1480 in pediatric malignancies using preclinical models of three highly malignant pediatric solid tumors: neuroblastoma (NB), rhabdomyosarcoma (RMS) and the Ewing Sarcoma Family Tumors (ESFT). In this study, we employed panels of biomedical and biological experiments to evaluate the in vitro and in vivo activity of AZD1480 in NB, RMS and ESFT. Our data indicate that AZD1480 blocks endogenous as well as IL-6 induced STAT3 activation. AZD1480 decreases cell viability in 7/7NB, 7/7RMS and 2/2 ESFT cell lines (median EC50 is 1.5 muM, ranging from 0.36-5.37muM). AZD1480  induces cell growth inhibition and caspase-dependent apoptosis in vitro and decreases expression of STAT3 target genes, including cell cycle regulators CyclinD1, 3 and CDC25A, anti-apoptotic genes Bcl-2 and survivin, the metastasis-related factor TIMP-1 and c-Myc. In vivo studies showed AZD1480 significantly decreased tumor growth and prolonged overall survival in tumor-bearing mice. Tumors from AZD1480-treated mice showed inhibition of activated STAT3 as well as decreased expression of STAT3 downstream targets. Our  study provides strong evidence of the anti-tumor growth potency of JAK inhibitor  AZD1480 in pediatric solid tumors, providing proof-of principle that inhibition of the JAK/STAT3 signal transduction could be a promising therapeutic target for  high-risk pediatric solid tumors.

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[515]

TÍTULO / TITLE:  - Cutaneous leiomyoma: novel histologic findings for classification and diagnosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Med Iran. 2013 Jan;51(1):19-24.

AUTORES / AUTHORS:  - Ghanadan A; Abbasi A; Kamyab Hesari K

INSTITUCIÓN / INSTITUTION:  - Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

RESUMEN / SUMMARY:  - Smooth muscle tumors rather benign or malignant can arise wherever the muscular tissue presents but cutaneous leiomyoma is one of the rare benign tumors of the which even the diagnostic criteria from the malignant type of the tumor is still  in doubt. This study was aimed to compare the subtypes of cutaneous leiomyoma from different histologic aspects in order to find unique criteria for better classification and diagnosis. The six year data base of our center was reviewed and 25 patients with cutaneous leiomyoma were included in this study. Of 25 patients, 5 were female and 20 were male. 5 patients had angioleiomyoma (ALM) and 20 had pilar leiomyoma (PLM). ALM had following characteristics: dilated vascular canals intermingled with compact smooth muscle bundles; well circumscribe counter and myxoid and hyaline changes through the tumor. In contrast, PLMs had following histologic features: poor defined outline, entrapped hair follicles and eccrine glands, acanthosis and elongated rete ridges with hyperpigmentation and smooth muscle bundles which are interdigitated with elongated rete ridges. Here we introduced some distinct histological features for each subtype of the cutaneous  leiomyoma which can lead to create novel criteria for classification and diagnosis of the lesion.

 

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[516]

TÍTULO / TITLE:  - Large Segmental Mandibulectomy for Treatment of an Undifferentiated Sarcoma in a  Horse.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Vet Surg. 2013 Feb 21. doi: 10.1111/j.1532-950X.2013.01086.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1532-950X.2013.01086.x

AUTORES / AUTHORS:  - Carmalt JL; Linn KA

INSTITUCIÓN / INSTITUTION:  - Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

RESUMEN / SUMMARY:  - OBJECTIVE: To describe a large segmental (sub-total) mandibulectomy for removal of an undifferentiated sarcoma in a horse. STUDY DESIGN: Clinical report. ANIMALS: A 10-year-old mare. METHODS: A combination of methods including computed tomography (CT) were used to diagnose a large undifferentiated sarcoma of the right mandible. A large segmental mandibulectomy extending from 3 cm below the right temporomandibular joint to immediately caudal to tooth 407 was used to perform an en-bloc resection of the mass under general anesthesia. RESULTS: Surgery time was 11 hours and 35 minutes and total anesthesia time, 12 hours and  40 minutes. The mare was eating well 3 days after surgery. Some postoperative skin sloughing occurred, but the cosmetic and functional outcome was good. The mare continued to do well, with no evidence of disease recurrence, 24 months after surgery. CONCLUSIONS: Three-dimensional reconstruction of the CT images was instrumental in surgical planning. A very large portion of the mandible can be removed in a horse with acceptable cosmetic and functional outcome.

 

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[517]

TÍTULO / TITLE:  - 1,2,3,4-Diepoxybutane-Induced DNA-Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Proteome Res. 2013 Apr 3.

            ●● Enlace al texto completo (gratuito o de pago) 1021/pr3011974

AUTORES / AUTHORS:  - Gherezghiher TB; Ming X; Villalta PW; Campbell C; Tretyakova NY

INSTITUCIÓN / INSTITUTION:  - Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota , Minneapolis, Minnesota 55455, United States.

RESUMEN / SUMMARY:  - 1,2,3,4-Diepoxybutane (DEB) is the key carcinogenic metabolite of 1,3-butadiene (BD), an important industrial and environmental chemical present in urban air and in cigarette smoke. DEB is a genotoxic bis-electrophile capable of cross-linking  cellular biomolecules to form DNA-DNA and DNA-protein cross-links (DPCs). In the  present work, mass spectrometry-based proteomics was employed to characterize DEB-mediated DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. Over 150 proteins including histones, high mobility group proteins, transcription factors, splicing factors, and tubulins were found among those covalently cross-linked to chromosomal DNA in the presence of DEB. A large portion of the cross-linked proteins are known factors involved in DNA binding, transcriptional  regulation, cell signaling, DNA repair, and DNA damage response. HPLC-ESI+-MS/MS  analysis of total proteolytic digests revealed the presence of 1-(S-cysteinyl)-4-(guan-7-yl)-2,3-butanediol conjugates, confirming that DEB forms DPCs between cysteine thiols within proteins and the N-7 guanine positions  within DNA. However, relatively high concentrations of DEB were required to achieve significant DPC formation, indicating that it is a poor cross-linking agent as compared to antitumor nitrogen mustards and platinum compounds.

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[518]

TÍTULO / TITLE:  - High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e55769. doi: 10.1371/journal.pone.0055769. Epub 2013 Jan 30.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0055769

AUTORES / AUTHORS:  - Satija NK; Sharma D; Afrin F; Tripathi RP; Gangenahalli G

INSTITUCIÓN / INSTITUTION:  - Stem Cell & Gene Therapy Research Group, Institute of Nuclear Medicine & Allied Sciences, Brig. S K Mazumdar Marg, Timarpur, Delhi, India.

RESUMEN / SUMMARY:  - Human mesenchymal stem cells (hMSCs) present in the bone marrow are the precursors of osteoblasts, chondrocytes and adipocytes, and hold tremendous potential for osteoregenerative therapy. However, achieving directed differentiation into osteoblasts has been a major concern. The use of lithium for enhancing osteogenic differentiation has been documented in animal models but its effect in humans is not clear. We, therefore, performed high throughput transcriptome analysis of lithium-treated hMSCs to identify altered gene expression and its relevance to osteogenic differentiation. Our results show suppression of proliferation and enhancement of alkaline phosphatase (ALP) activity upon lithium treatment of hMSCs under non-osteogenic conditions. Microarray profiling of lithium-stimulated hMSC revealed decreased expression of  adipogenic genes (CEBPA, CMKLR1, HSD11B1) and genes involved in lipid biosynthesis. Interestingly, osteoclastogenic factors and immune responsive genes (IL7, IL8, CXCL1, CXCL12, CCL20) were also downregulated. Negative transcriptional regulators of the osteogenic program (TWIST1 and PBX1) were suppressed while genes involved in mineralization like CLEC3B and ATF4 were induced. Gene ontology analysis revealed enrichment of upregulated genes related  to mesenchymal cell differentiation and signal transduction. Lithium priming led  to enhanced collagen 1 synthesis and osteogenic induction of lithium pretreated MSCs resulted in enhanced expression of Runx2, ALP and bone sialoprotein. However, siRNA-mediated knockdown of RRAD, CLEC3B and ATF4 attenuated lithium-induced osteogenic priming, identifying a role for RRAD, a member of small GTP binding protein family, in osteoblast differentiation. In conclusion, our data highlight the transcriptome reprogramming potential of lithium resulting in higher propensity of lithium “primed” MSCs for osteoblastic differentiation.

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[519]

TÍTULO / TITLE:  - Astrocyte elevated gene-1 regulates osteosarcoma cell invasion and chemoresistance via endothelin-1/endothelin A receptor signaling.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Feb;5(2):505-510. Epub 2012 Dec 3.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1056

AUTORES / AUTHORS:  - Liu B; Wu Y; Peng D

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

RESUMEN / SUMMARY:  - Astrocyte elevated gene-1 (AEG-1) and endothelin-1 (ET-1)/endothelin A receptor (ETAR) signaling have been demonstrated to be important in osteosarcoma (OS) progression. In the present study, we explored the interaction between AEG-1 and  ET-1/ETAR signaling in OS cells, and investigated the mechanism(s) through which  the functional interaction may impact OS cell invasion and chemoresistance. Overexpression and knockdown of AEG-1 were performed in Saos-2 and MG-63 OS cells, respectively. Overexpression of AEG-1 in Saos-2 cells significantly increased ET-1 expression (at both the mRNA and protein levels), cell invasion, MMP-2 expression and cell survival against cisplatin. These effects were eradicated using a selective phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, or a selective ETAR inhibitor, BQ123. Knockdown of AEG-1 in MG-63 cells significantly decreased ET-1 expression (at both the mRNA and protein levels), cell invasion, MMP-2 expression and cell survival against cisplatin. Exogenous ET-1 restored cell invasion and MMP-2 expression levels in MG-63 cells, in which  AEG-1 had been knocked down, in the presence of LY294002, but not in the presence of BQ123. However, exogenous ET-1 only partially rescued cell survival against cisplatin-induced apoptosis in the presence of LY294002, in cells in which AEG-1  had been knocked down. In conclusion, we have demonstrated that AEG-1 regulates ET-1 expression at the transcriptional level in a PI3K-dependent manner in OS cells. Downstream of PI3K, ET-1/ETAR signaling primarily mediates the promoting effect of AEG-1 on OS cell invasion, likely through the upregulation of MMP-2 expression, thus, ET-1/ETAR signaling partially, but significantly, mediates the  AEG-1-induced chemoresistance in OS cells. To the best of our knowledge, this study has provided the first evidence of a functional association between AEG-1 and ET-1/ETAR signaling in OS cells, which adds novel insights into the molecular mechanism of OS metastasis and chemoresistance.

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[520]

TÍTULO / TITLE:  - Juvenile female with chest wall fibromatosis located posteriorly to the right breast: radiation therapy or wait and watch?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Feb 20;2013. pii: bcr2012006355. doi: 10.1136/bcr-2012-006355.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-006355

AUTORES / AUTHORS:  - Akhavan A; Binesh F; Kargar K; Navabii H

INSTITUCIÓN / INSTITUTION:  - Department of Radiotherapy, Shahid Sadoghi University of Medical Sciences, Yazd,  Iran. ali52akhavan@yahoo.com

RESUMEN / SUMMARY:  - Fibromatosis is a slow-growing monoclonal proliferation of fibroblasts. Although  histologically benign it is locally invasive and can recur, however, without metastatic potential. Extra-abdominal fibromatosis is not common. Surgical resection is the cornerstone of treatment and radiation therapy is used in incomplete resection, however, its role is not proved through prospective randomised trials. This article presents a 17-year-old Iranian girl with chest wall fibromatosis located just behind the right breast. The patient was operated  with positive margin, however, we decided to postpone radiation therapy because of potential risks.

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[521]

TÍTULO / TITLE:  - Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - BMB Rep. 2013 Feb;46(2):113-8.

AUTORES / AUTHORS:  - Zhou C; Shen Q; Xue J; Ji C; Chen J

INSTITUCIÓN / INSTITUTION:  - State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.

RESUMEN / SUMMARY:  - TTRAP is a multi-functional protein that is involved in multiple aspects of cellular functions including cell proliferation, apoptosis and the repair of DNA  damage. Here, we demonstrated that the lentivirus-mediated overexpression of TTRAP significantly inhibited cell growth and induced apoptosis in osteosarcoma cells. The ectopic TTRAP suppressed the growth and colony formation capacity of two osteosarcoma cell lines, U2OS and Saos-2. Cell apoptosis was induced in U2OS  cells and the cell cycle was arrested at G2/M phase in Saos-2 cells. Exogenous expression of TTRAP in serum-starved U2OS and Saos-2 cells induced an increase in caspase-3/-7 activity and a decrease in cyclin B1 expression. In comparison with  wild-type TTRAP, mutations in the 5’-tyrosyl-DNA phosphodiesterase activity of TTRAP, in particular TTRAP(E152A), showed decreased inhibitory activity on cell growth. These results may aid in clarifying the physiological functions of TTRAP, especially its roles in the regulation of cell growth and tumorigenesis.

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[522]

TÍTULO / TITLE:  - Clinical outcomes of gastrointestinal stromal tumor in southern Thailand.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastrointest Oncol. 2012 Nov 15;4(11):216-22. doi: 10.4251/wjgo.v4.i11.216.

            ●● Enlace al texto completo (gratuito o de pago) 4251/wjgo.v4.i11.216

AUTORES / AUTHORS:  - Pornsuksiri K; Chewatanakornkul S; Kanngurn S; Maneechay W; Chaiyapan W; Sangkhathat S

INSTITUCIÓN / INSTITUTION:  - Kittima Pornsuksiri, Siripong Chewatanakornkul, Walawee Chaiyapan, Surasak Sangkhathat, Department of Surgery and Tumor Biology Research Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

RESUMEN / SUMMARY:  - AIM: To review a single institutional experience in clinical management of gastrointestinal stromal tumors (GIST) and analyze for factors determining treatment outcome. METHODS: Clinicopathological data of patients with a diagnosis of GIST who were treated at our institute during November 2004 to September 2009  were retrospectively reviewed. RESULTS: Ninety-nine cases were included in the analysis. Primary tumor sites were at the stomach in and small bowel in 44% and 33%, respectively. Thirty-one cases already had metastasis at presentation and the most common metastatic site was the liver. Sixty-four cases (65%) were in the high-risk category. Surgical treatment was performed in 77 cases (78%), 3 of whom received upfront targeted therapy. Complete resection was achieved in 56 cases (73% of operative cases) and of whom 27 developed local recurrence or distant metastasis at a median duration of 2 years. Imatinib was given as a primary therapy in unresectable cases (25 cases) and as an adjuvant in cases with residual tumor (21 cases). Targeted therapy gave partial response in 7 cases (15%), stable disease in 27 cases (57%) and progressive disease in 13 cases (28%). Four-year overall survival was 74% (95% CI: 61%-83%). Univariate survival  analysis found that low-risk tumor, gastric site, complete resection and response to imatinib were associated with better survival. CONCLUSION: The overall outcomes of GIST can be predicted by risk-categorization. Surgery alone may not be a curative treatment for GIST. Response to targeted therapy is a crucial survival determinant in these patients.

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[523]

TÍTULO / TITLE:  - Metastasis of osteosarcoma to stomach made clinically evident by hematemesis: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Feb 26;11:48. doi: 10.1186/1477-7819-11-48.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-48

AUTORES / AUTHORS:  - Urakawa H; Tsukushi S; Tsurudome I; Hirata A; Arai E; Kozawa E; Futamura N; Miyahara R; Ishiguro N; Nishida Y

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, Nagoya University Graduate School and School of Medicine, 65 Tsurumai, Showa-ku, 466-8550, Nagoya, Aichi, Japan. urakawa@med.nagoya-u.ac.jp.

RESUMEN / SUMMARY:  - BACKGROUND: Gastric metastasis from osteosarcoma is very rare and its clinical features are not well recognized. CASE PRESENTATION: A 73-year-old man was diagnosed with osteosarcoma and treated with four cycles of preoperative chemotherapy with ifosfamide and doxorubicin followed by wide resection. Two cycles of postoperative chemotherapy with ifosfamide and doxorubicin and ten cycles of chemotherapy with carboplatin and etoposide were administered. Eleven months after the surgery, he vomited fresh blood. Unusual progression of anemia was observed with the hematemesis. A biopsy was performed by gastrointestinal endoscopy, and the stomach tumor was diagnosed as metastasis of osteosarcoma. CONCLUSIONS: Even though gastric metastasis from osteosarcoma is very rare, all three previous reports and our case showed the presence of ulcer on the surface of the gastric lesion. We should consider the possibility of gastric metastasis in patients with osteosarcoma in whom progression of anemia or gastric hemorrhage is observed.

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[524]

TÍTULO / TITLE:  - Multiply recurrent solitary fibrous tumor of the orbit without malignant degeneration: a 45-year clinicopathologic case study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JAMA. Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista jama.ama-assn.org/search.dtl 

            ●● Cita: JAMA: <> Ophthalmol. 2013 Feb;131(2):265-7. doi: 10.1001/2013.jamaophthalmol.69.

            ●● Enlace al texto completo (gratuito o de pago) 1001/2013.jamaophthalmol.69

AUTORES / AUTHORS:  - Griepentrog GJ; Harris GJ; Zambrano EV

INSTITUCIÓN / INSTITUTION:  - Section of Oculofacial and Orbital Surgery, Department of Ophthalmology, Medical  College of Wisconsin, 925 N 87th St, Milwaukee, WI 53226, USA. ggriepentrog@mcw.edu

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[525]

TÍTULO / TITLE:  - Imaging features of primary anorectal gastrointestinal stromal tumors with clinical and pathologic correlation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Imaging. 2013 Feb 8;12:557-65. doi: 10.1102/1470-7330.2012.0048.

            ●● Enlace al texto completo (gratuito o de pago) 1102/1470-7330.2012.0048

AUTORES / AUTHORS:  - Koch MR; Jagannathan JP; Shinagare AB; Krajewski KM; Raut CP; Hornick JL; Ramaiya NH

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA.

RESUMEN / SUMMARY:  - PURPOSE: To evaluate the imaging features of anorectal gastrointestinal stromal tumors (GISTs) with clinical and histopathologic correlation. MATERIALS AND METHODS: In this Institutional Review Board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study, 16 patients (12 men; mean age 66 years (30-89 years)) with pathologically proven anorectal GISTs  seen at our institution from January 2001 to July 2011 were identified. Electronic medical records were reviewed to obtain clinical data. Pretreatment imaging studies (computed tomography (CT) in 16 patients, magnetic resonance imaging (MRI) in 9 patients and fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT in 8 patients) were evaluated by 2 radiologists until consensus. The location, size and imaging features of the primary tumor and metastases at presentation, if any, were recorded, and correlated with clinical data and pathologic features (histologic type, presence of necrosis, mitotic activity, risk category, immunohistochemical profile). RESULTS: The mean tumor size was 6.9 x 6.0 cm. Of the 16 tumors, 11 (68.7%) were infralevator, 4 (25%) supra and infralevator and 1 (6.3%) supralevator; 9 (56.2%) were exophytic, 6 (37.5%) both exophytic and intraluminal, and 1 (6.3%) was intraluminal. The tumors were iso- to minimally hypoattenuating to muscle on CT, iso- to minimally  hypointense on T1-weighted images, hyperintense on T2-weighted images and showed  variable enhancement. Necrosis was seen in 4 (25%), and hemorrhage and calcification in 2 (12.5%) patients each. The tumors were FDG avid with a mean maximum standardized uptake value of 11 (8.4-16.8). All tumors were positive for  KIT and CD34. Distant metastasis to liver was seen in 1 patient (6.3%) at presentation. CONCLUSION: Anorectal GISTs are well-circumscribed, non-circumferential, predominantly infralevator, intramural or exophytic, FDG-avid, hypoattenuating masses, and present without lymphadenopathy or intestinal obstruction.

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[526]

TÍTULO / TITLE:  - Cardiac angiosarcoma discovered at a pacemaker implantation procedure.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Med Res. 2012 Dec;136(6):1063.

AUTORES / AUTHORS:  - Pop C; Fetcu A

INSTITUCIÓN / INSTITUTION:  - “ Vasile Goldis” West University Faculty of Medicine Arad; County Emergency Hospital Baia Mare, Romania.

 

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[527]

TÍTULO / TITLE:  - Three cases of intraocular mesectodermal leiomyoma expressing progesterone and androgen receptors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eye (Lond). 2013 Mar 22. doi: 10.1038/eye.2013.37.

            ●● Enlace al texto completo (gratuito o de pago) 1038/eye.2013.37

AUTORES / AUTHORS:  - Quhill H; Rennie IG; Rundle PA; Mudhar HS

INSTITUCIÓN / INSTITUTION:  - Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.

RESUMEN / SUMMARY:  - Background/AimsA prospective study identified three patients between 2004 and 2010 with mesectodermal leiomyoma. The study was conducted to analyse the presence or absence of sex steroid hormone receptors in mesectodermal leiomyomas.MethodsThe clinical features were collated. All three patients had operative procedures to either remove or sample the mesectodermal leiomyomas. The tissue was fixed in formalin and exposed to conventional histological processing. Immunohistochemistry using antibodies to androgen (AR), oestrogen (ER), and progesterone (PR) receptors was performed, followed by stain scoring to assess for expression status.ResultsAll three cases were confirmed by histology to be examples of mesectodermal leiomyomas. All three expressed sex steroid hormone receptors. One case expressed both PR and AR, one case PR only and another case AR only. None of the cases expressed ER receptors.ConclusionAll three cases displayed some sex steroid hormone receptor expression. This is supportive evidence that sex steroid hormones may have a role in the pathogenesis of this tumour and suggest that it may be amenable to hormonal manipulation therapy, in a manner similar to conventional uterine leiomyomas.Eye advance online publication, 22 March 2013; doi:10.1038/eye.2013.37.

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[528]

TÍTULO / TITLE:  - TWIST interacts with endothelin-1/endothelin A receptor signaling in osteosarcoma cell survival against cisplatin.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Mar;5(3):857-861. Epub 2013 Jan 7.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2013.1111

AUTORES / AUTHORS:  - Zhou Y; Zang X; Huang Z; Zhang C

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, The Third Xiangya Hospital, Central South University, Hunan, Changsha 410013, P.R. China.

RESUMEN / SUMMARY:  - Both TWIST and the endothelin-1 (ET-1)/endothelin A receptor (ETAR) signaling are important in osteosarcoma (OS) progression. In the present study, the interaction between TWIST and ET-1/ETAR signaling in OS cells was investigated, and the impact of the functional interaction on OS cell survival against chemotherapy agent-induced apoptosis was assessed. TWIST was overexpressed and knocked down in Saos-2 and MG-63 OS cells, respectively. In Saos-2 cells, overexpression of TWIST significantly decreased ET-1 mRNA and protein expression levels, cell survival against cisplatin and phosphorylation of Akt at serine 473 (ser473), which was abolished by the selective phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, or the selective ETAR inhibitor, BQ123. In MG-63 cells, knockdown of TWIST significantly increased ET-1 expression, cell survival against cisplatin and phosphorylation of Akt at ser473. However, exogenous ET-1 only partially rescued cell survival against cisplatin-induced apoptosis in the cells in which TWIST had been knocked down in the presence of LY294002. In conclusion, we have demonstrated that TWIST significantly, although only partially, decreases OS cell survival against cisplatin by downregulating ET-1/ETAR signaling via inhibition of the PI3K/Akt pathway. To the best of our knowledge, the present study has provided the first evidence of a functional interaction between TWIST and ET-1/ETAR signaling in OS cells. This finding adds novel insights into the molecular mechanisms underlying OS progression, cell survival and chemoresistance.

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[529]

TÍTULO / TITLE:  - Follicular dendritic cell sarcoma of the omentum: multidetector computed tomography findings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Radiol. 2013 Mar;14(2):213-7. doi: 10.3348/kjr.2013.14.2.213. Epub 2013  Feb 22.

            ●● Enlace al texto completo (gratuito o de pago) 3348/kjr.2013.14.2.213

AUTORES / AUTHORS:  - Chien JC; Lao WT; Chen CL; Chan WP

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.

RESUMEN / SUMMARY:  - We report computed tomography (CT) findings for a rare case of follicular dendritic cell sarcoma of the greater omentum from a 47-year-old female patient.  The tumor presented ash a palpable mass lesion in the umbilical region for the last two months. Multidetector CT scan of the abdomen showed a 14-cm soft-tissue  mass with calcification and necrosis within the greater omentum. As a result, a follicular dendritic cell sarcoma should be considered in the differential diagnosis of a solitary omentum mass, especially one with coarse and chunk-like calcifications.

 

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[530]

TÍTULO / TITLE:  - Incessant ventricular tachycardia due to multiple cardiac rhabdomyomas in an infant with Tuberous Sclerosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian Heart J. 2013 Jan-Feb;65(1):111-3. doi: 10.1016/j.ihj.2012.12.003. Epub 2012 Dec 25.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ihj.2012.12.003

AUTORES / AUTHORS:  - Kathare PA; Muthuswamy KS; Sadasivan J; Calumbar N; Koneti NR

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Cardiology, CARE Institute of Medical Sciences, Road No 1, Banjara Hills, Hyderabad 500034, Andhra Pradesh, India.

RESUMEN / SUMMARY:  - We report a case of incessant ventricular tachycardia managed successfully with medications. The transthoracic echocardiogram showed multiple cardiac rhabdomyomas involving ventricular free wall and outflow tracts. Computerized tomography of brain showed multiple subependymal tubers confirming Tuberous Sclerosis. The follow up assessment showed sinus rhythm and regressing cardiac rhabdomyomas.

 

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[531]

TÍTULO / TITLE:  - FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and  in vivo.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e55034. doi: 10.1371/journal.pone.0055034. Epub 2013 Jan 28.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0055034

AUTORES / AUTHORS:  - Brun J; Dieudonne FX; Marty C; Muller J; Schule R; Patino-Garcia A; Lecanda F; Fromigue O; Marie PJ

INSTITUCIÓN / INSTITUTION:  - INSERM UMR 606, Paris, France.

RESUMEN / SUMMARY:  - BACKGROUND: The molecular mechanisms that are involved in the growth and invasiveness of osteosarcoma, an aggressive and invasive primary bone tumor, are  not fully understood. The transcriptional co-factor FHL2 (four and a half LIM domains protein 2) acts as an oncoprotein or as a tumor suppressor depending on the tissue context. In this study, we investigated the role of FHL2 in tumorigenesis in osteosarcoma model. METHODOLOGY/PRINCIPAL FINDINGS: Western blot analyses showed that FHL2 is expressed above normal in most human and murine osteosarcoma cells. Tissue microarray analysis revealed that FHL2 protein expression is high in human osteosarcoma and correlates with osteosarcoma aggressiveness. In murine osteosarcoma cells, FHL2 silencing using shRNA decreased canonical Wnt/beta-catenin signaling and reduced the expression of Wnt  responsive genes as well as of the key Wnt molecules Wnt5a and Wnt10b. This effect resulted in inhibition of osteosarcoma cell proliferation, invasion and migration in vitro. Using xenograft experiments, we showed that FHL2 silencing markedly reduced tumor growth and lung metastasis occurence in mice. The anti-oncogenic effect of FHL2 silencing in vivo was associated with reduced cell  proliferation and decreased Wnt signaling in the tumors. CONCLUSION/SIGNIFICANCE: Our findings demonstrate that FHL2 acts as an oncogene in osteosarcoma cells and  contributes to tumorigenesis through Wnt signaling. More importantly, FHL2 depletion greatly reduces tumor cell growth and metastasis, which raises the potential therapeutic interest of targeting FHL2 to efficiently impact primary bone tumors.

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[532]

TÍTULO / TITLE:  - Extensive Resection and Double-Patch Reconstruction for Left Atrial Myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2013 Mar 26.

AUTORES / AUTHORS:  - Morokuma H; Katayama Y; Kamohara K; Minematsu N; Koga S

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic and Cardiovascular Surgery, Fukuoka Tokushukai Hospital.

RESUMEN / SUMMARY:  - The efficacy and safety of surgical intervention for atrial myxoma are established, but the operative approach to tumor resection and atrial reconstruction are controversial. A biatrial approach is generally used for excision of atrial myxoma and has many advantages. In contrast, there are a few reports about the method of double-patch reconstruction, and the right and left atrium are individually reconstructed with the two patches. We found it to be effective in the case reported here. We suggest that this method can be applied to atrial myxoma in which extensive resection is necessary.

 

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[533]

TÍTULO / TITLE:  - CT-guided percutaneous drilling is a safe and reliable method of treating osteoid osteomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Springerplus. 2013 Dec;2(1):34. Epub 2013 Jan 31.

            ●● Enlace al texto completo (gratuito o de pago) 1186/2193-1801-2-34

AUTORES / AUTHORS:  - Engel EE; Gava NF; Nogueira-Barbosa NF; Botter FA

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics and Traumatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Hospital das Clinicas 11 degrees andar, Av. Bandeirantes, 3900, Monte Alegre, Ribeirao Preto, SP 14049-900 Brazil.

RESUMEN / SUMMARY:  - Computed tomography (CT)-guided percutaneous drilling is an alternative for osteoid osteoma treatment. This study aims to evaluate the remodeling of the drill orifice. The success rate and complications were also recorded and compared with other treatment methods. Fifteen patients with an average age of fourteen years (ranging from 4 to 25) submitted to CT-guided percutaneous drilling between 2003 and 2009 were retrospectively analyzed according to clinical and radiological criteria. Fourteen cases showed complete alleviation of pain one week after surgery. No relapse was detected even in the subject who continued complaining of pain. All patients were treated with a day-hospital regimen and were discharged with partial weight bearing. Total weight bearing was allowed after one month, and sports were allowed after consolidation, which occurred in all but one case after the third month. One patient, who did not follow our medical advice, returned to sports activities after two weeks and experienced a fracture as a result. Atrophy of the vastus lateralis muscle developed after the  procedure in another patient. Our case series suggests that this method is reliable and safe. The level of complexity is comparable with other minimally invasive percutaneous procedures. The cost is low because there is no need to buy probes or other equipment. The negative points include weakening of the bone and  the logistical problem of assembling the orthopedic surgeon, radiologist, and anesthesiologist in the tomography room.

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[534]

TÍTULO / TITLE:  - Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hand Surg. 2013;18(1):115-20. doi: 10.1142/S021881041372009X.

            ●● Enlace al texto completo (gratuito o de pago) 1142/S021881041372009X

AUTORES / AUTHORS:  - Deshmukh SD; Gulati HK; Yadav P; Naik P

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Smt Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra, India.

RESUMEN / SUMMARY:  - The most common soft tissue sarcomas of hand are epitheloid sarcomas, synovial sarcomas and malignant fibrous histiocytomas which are high grade, aggressive tumors. Liposarcomas of the hand are extremely rare and to the best of our knowledge less than 20 cases have been reported so far in the literature. Well differentiated spindle cell liposarcoma is an extremely rare subtype of well differentiated liposarcoma/atypical lipomatous tumor which is different from the  other subtypes clinicopathologically, genetically and prognostically. Palmar localization of this rare variant of liposarcoma at this site makes ours only the second case reported in the world literature so far. This recently described entity is low grade lesion and the hand surgeons need to adopt a less aggressive  approach in the treatment of this subtype.

 

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[535]

TÍTULO / TITLE:  - OstemiR: A Novel Panel of MicroRNA Biomarkers in Osteoblastic and Osteocytic Differentiation from Mesencymal Stem Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(3):e58796. doi: 10.1371/journal.pone.0058796. Epub 2013 Mar 22.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0058796

AUTORES / AUTHORS:  - Eguchi T; Watanabe K; Hara ES; Ono M; Kuboki T; Calderwood SK

INSTITUCIÓN / INSTITUTION:  - Department of Oral Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan ; Division of Molecular and Cellular Biology, Department  of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

RESUMEN / SUMMARY:  - MicroRNAs (miRNAs) are small RNA molecules of 21-25 nucleotides that regulate cell behavior through inhibition of translation from mRNA to protein, promotion of mRNA degradation and control of gene transcription. In this study, we investigated the miRNA expression signatures of cell cultures undergoing osteoblastic and osteocytic differentiation from mesenchymal stem cells (MSC) using mouse MSC line KUSA-A1 and human MSCs. Ninety types of miRNA were quantified during osteoblastic/osteocytic differentiation in KUSA-A1 cells utilizing miRNA PCR arrays. Coincidently with mRNA induction of the osteoblastic  and osteocytic markers, the expression levels of several dozen miRNAs including miR-30 family, let-7 family, miR-21, miR-16, miR-155, miR-322 and Snord85 were changed during the differentiation process. These miRNAs were predicted to recognize osteogenic differentiation-, stemness-, epinegetics-, and cell cycle-related mRNAs, and were thus designated OstemiR. Among those OstemiR, the miR-30 family was classified into miR-30b/c and miR-30a/d/e groups on the basis of expression patterns during osteogenesis as well as mature miRNA structures. In silico prediction and subsequent qRT-PCR in stable miR-30d transfectants clarified that context-dependent targeting of miR-30d on known regulators of bone formation including osteopontin/spp1, lifr, ccn2/ctgf, ccn1/cyr61, runx2, sox9 as well as novel key factors including lin28a, hnrnpa3, hspa5/grp78, eed and pcgf5.  In addition, knockdown of human OstemiR miR-541 increased Osteopontin/SPP1 expression and calcification in hMSC osteoblastic differentiation, indicating that miR-541 is a negative regulator of osteoblastic differentiation. These observations indicate stage-specific roles of OstemiR especially miR-541 and the  miR-30 family on novel targets in osteogenesis.

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[536]

TÍTULO / TITLE:  - Virus activated artificial ECM induces the osteoblastic differentiation of mesenchymal stem cells without osteogenic supplements.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sci Rep. 2013;3:1242. doi: 10.1038/srep01242. Epub 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1038/srep01242

AUTORES / AUTHORS:  - Wang J; Wang L; Li X; Mao C

INSTITUCIÓN / INSTITUTION:  - Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK 73019, USA.

RESUMEN / SUMMARY:  - Biochemical and topographical features of an artificial extracellular matrix (aECM) can direct stem cell fate. However, it is difficult to vary only the biochemical cues without changing nanotopography to study their unique role. We took advantage of two unique features of M13 phage, a non-toxic nanofiber-like virus, to generate a virus-activated aECM with constant ordered ridge/groove nanotopography but displaying different fibronectin-derived peptides (RGD, its synergy site PHSRN, and a combination of RGD and PHSRN). One feature is the self-assembly of phage into a ridge/groove structure, another is the ease of genetically surface-displaying a peptide. We found that the unique ridge/groove nanotopography and the display of RGD and PHSRN could induce the osteoblastic differentiation of mesenchymal stem cells (MSCs) without any osteogenic supplements. The aECM formed through self-assembly and genetic engineering of phage can be used to understand the role of peptide cues in directing stem cell behavior while keeping nanotopography constant.

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[537]

TÍTULO / TITLE:  - Successful management of an intra-operative pulmonary tumor embolism during resection of a retroperitoneal leiomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chin Med J (Engl). 2013 Mar;126(5):980-1.

AUTORES / AUTHORS:  - Zhu SM; Guo SH; Li LJ; Luo LH; Yao YX

INSTITUCIÓN / INSTITUTION:  - Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.

 

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[538]

TÍTULO / TITLE:  - Cost effectiveness of liposomal doxorubicin vs. paclitaxel for the treatment of advanced AIDS-Kaposi’s sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Econ. 2013 Mar 1.

            ●● Enlace al texto completo (gratuito o de pago) 3111/13696998.2013.777347

AUTORES / AUTHORS:  - Raimundo K; Biskupiak J; Goodman M; Silverstein S; Asche C

INSTITUCIÓN / INSTITUTION:  - University of Utah, Pharmacotherapy Outcomes Research Center , Salt Lake City , USA.

RESUMEN / SUMMARY:  - Abstract Objective: Epidemic Kaposi’s sarcoma (KS) is one of the most common acquired immune deficiency syndrome (AIDS) defining malignancies, a disease with  stigmatized clinical features that characterizes the diagnosis of AIDS. This study aims to perform a cost-effectiveness analysis between liposomal doxorubicin and paclitaxel in treating AIDS-KS. Methods: A 21 week decision tree analysis was created using a hospital perspective to compare treatment patterns with liposomal doxorubicin and paclitaxel. All costs were calculated in 2011 US dollars and obtained from an academic treatment center. Acquisition costs were obtained from  public estimates using wholesale acquisition cost (WAC). Effectiveness was estimated based on a Phase 3 study of liposomal doxorubicin and paclitaxel (Von-Roenn et al.). Adverse events (AEs) associated with treatment and not the disease were included in the analysis. One-way sensitivity analysis was performed to test the robustness of the results. Results: Cost minimization analysis showed that treatment with liposomal doxorubicin was $18,125 whereas paclitaxel costs $12,347. After accounting for response rate, the results showed that liposomal doxorubicin costs $39,403 versus $21,661 for paclitaxel. This study has some limitations. Clinical data were derived from different clinical trials. In addition, many assumptions were made. Conclusion: Paclitaxel is dominant due to its lower acquisition cost and high response rate. Acquisition cost of liposomal  doxorubicin and paclitaxel are significantly different. After accounting for all  the factors that contribute to cost and response rate, paclitaxel is more cost effective than liposomal doxorubicin.

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[539]

TÍTULO / TITLE:  - Successful surgical treatment of a right atrial myxoma complicated by pulmonary embolism.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Thorac Cardiovasc Surg. 2013 Feb;46(1):63-7. doi: 10.5090/kjtcs.2013.46.1.63. Epub 2013 Feb 6.

            ●● Enlace al texto completo (gratuito o de pago) 5090/kjtcs.2013.46.1.63

AUTORES / AUTHORS:  - Jung J; Hong YS; Lee CJ; Lim SH; Choi H; Lee S

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, Korea.

RESUMEN / SUMMARY:  - A 76-year-old woman with hypertension was admitted to the hospital with complaints of chest pain and dyspnea. An echocardiogram and pulmonary computed tomography angiography showed right atrial myxoma complicated with pulmonary thromboembolism. An operation to resect the right atrial myxoma and pulmonary embolism was recommended; however, the patient refused and was discharged with anticoagulation therapy. Two years later, she developed dyspnea. Radiological studies and echocardiography showed similar results with the previous findings. The patient underwent mediastinotomy with resection of the right atrial myxoma and pulmonary embolectomy. As there are few reports on right atrial myxoma complicated with pulmonary embolism, we report a successful case of surgical removal of right atrial myxoma and pulmonary embolism.

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[540]

TÍTULO / TITLE:  - Misdiagnosed myeloid sarcoma of the vulva.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chin Med J (Engl). 2013 Mar;126(5):984-5.

AUTORES / AUTHORS:  - He Y; Li XD; Huang Y; Wang DN; Hu Y; Huang RW

INSTITUCIÓN / INSTITUTION:  - Department of Hematology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.

 

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[541]

TÍTULO / TITLE:  - Bleeding popliteal mass: a diagnostic dilemma and novel clinical presentation of  angiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Hosp Med (Lond). 2012 Dec 11;73(12):713-Unknown.

AUTORES / AUTHORS:  - Morley O; Naughton J; Witherspoon J; H Lewis M

RESUMEN / SUMMARY:  - Images in medicine.

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[542]

TÍTULO / TITLE:  - Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cell Death Dis. 2013 Mar 28;4:e566. doi: 10.1038/cddis.2013.101.

            ●● Enlace al texto completo (gratuito o de pago) 1038/cddis.2013.101

AUTORES / AUTHORS:  - Fu W; Sharma SS; Ma L; Chu B; Bui MM; Reed D; Pledger WJ

INSTITUCIÓN / INSTITUTION:  - Department of Molecular Oncology, Gonzmart Research Laboratory, and the Sarcoma Research Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

RESUMEN / SUMMARY:  - Osteosarcoma (OS) is an aggressive bone cancer typically observed in adolescents  and young adults. Metastatic relapse accounts primarily for treatment failure, and obstacles to improving cure rates include a lack of efficacious agents. Our studies show apoptosis of OS cells prepared from localized and metastatic tumors  by a novel drug combination: SCH727965 (SCH), a cyclin-dependent kinase inhibitor, and NVP-AUY922 (AUY) or other heat shock protein 90 inhibitor. SCH and AUY induced apoptosis when added simultaneously to cells and when AUY was added to and removed from cells before SCH addition. Sequential treatment was most effective when cells received AUY for approximately 12 h and when SCH was presented to cells immediately after AUY removal. The apoptotic protein Bax accumulated in mitochondria of cotreated cells but was primarily cytosolic in cells receiving either agent alone. Additional data show that SCH and AUY cooperatively induce the apoptosis of other sarcoma cell types but not of normal  osteoblasts or fibroblasts, and that SCH and AUY individually inhibit cell cycle  progression throughout the cell cycle. We suggest that the combination of SCH and AUY may be an effective new strategy for treatment of OS.

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[543]

TÍTULO / TITLE:  - The KIT Exon 11 Stop Codon Mutation in Gastrointestinal Stromal Tumors: What Is the Clinical Meaning?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gut Liver. 2013 Jan;7(1):35-40. doi: 10.5009/gnl.2013.7.1.35. Epub 2012 Dec 5.

            ●● Enlace al texto completo (gratuito o de pago) 5009/gnl.2013.7.1.35

AUTORES / AUTHORS:  - Michelucci A; Chiappetta C; Cacciotti J; Veccia N; Astri E; Leopizzi M; Prosperi Porta R; Petrozza V; Della Rocca C; Bevilacqua G; Cavazzana A; Di Cristofano C

INSTITUCIÓN / INSTITUTION:  - Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, Pisa University Hospital, University of Pisa, Pisa, Italy.

RESUMEN / SUMMARY:  - BACKGROUND/AIMS: Gastrointestinal stromal tumors (GISTs) strongly express a receptor tyrosine kinase (RTK, c-KIT-CD117) harboring a KIT mutation that causes  constitutive receptor activation leading to the development and growth of tumors; 35% of GISTs without KIT mutations have platelet-derived growth factor receptor alpha (PDGFRA) mutations, and the type of mutation plays an important role in the response to treatment. This study aimed to establish the frequency of stop codon  mutations in the RTKs, KIT, and PDGFRA, in GISTs and correlate this molecular alteration with protein expression and treatment responsiveness. METHODS: Seventy-nine GISTs were analyzed for both KIT and PDGFRA mutations. Immunohistochemical expression was studied in tissue microarray blocks. RESULTS:  We found three rare KIT mutations in exon 11 that induced a stop codon, two at position 563 and one at position 589, which have never been described before. All three tumors were CD117-, DOG1-, and CD34-positive. Two patients with a KIT stop  codon mutation did not respond to imatinib therapy and died shortly after treatment. CONCLUSIONS: The association between stop codon mutations in KIT and patient survival, if confirmed in a larger population, may be useful in choosing  effective therapies.

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[544]

TÍTULO / TITLE:  - Susceptibility artifacts in lipomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neurol India. 2013 Jan-Feb;61(1):56-9. doi: 10.4103/0028-3886.108012.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0028-3886.108012

AUTORES / AUTHORS:  - Lingegowda D; Rajashekar C; Belaval VV; Thomas B; Keshavdas C

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic and Interventional Radiology, Narayana Hrudayalaya and Muzumdar Shaw Cancer Center, Bangalore, Karnataka, India.

RESUMEN / SUMMARY:  - Background: Intracranial lipomas are uncommon tumors, which produce susceptibility artifacts on susceptibility weighted images. The cause for the susceptibility artifact on SWI images remains speculative. Our purpose was identifying the possible causes of susceptibility artifacts in lipoma. Materials  and Methods: We retrospectively reviewed 15 cases harboring 16 lipomas of head region. All the lipomas are evaluated on SWI images for the presence of blooming  and types of blooming artifacts. Computed tomography (CT) images were evaluated for presence of calcification. Results: All three pericallosal tubulonodular lipomas showed peripheral rim-like susceptibility artifacts. All the curvilinear  lipomas (four cases) showed complete blooming. Five out of eight nodular lipomas  showed peripheral susceptibility artifacts, whereas, one showed complete blooming. Two nodular lipomas showed peripheral and central susceptibility artifacts. Scalp and craniovertebral lipomas (four in number) showed peripheral susceptibility artifacts. Specks of calcification were identified in two out of seven cases on CT scan. Conclusions: Contribution of the macroscopic calcification to susceptibility blooming appears to be insignificant. Microscopic mineralization and chemical shift artifact appears to be a major cause of susceptibility blooming.

 

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[545]

TÍTULO / TITLE:  - Chronic lymphedema of filarial origin: a very rare etiology of cutaneous lymphangiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Dermatol. 2013 Jan;58(1):71-3. doi: 10.4103/0019-5154.105315.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0019-5154.105315

AUTORES / AUTHORS:  - Agale SV; Khan WA; Chawlani K

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Grant Medical College and Sir J.J. Group of Hospitals, Mumbai, India.

RESUMEN / SUMMARY:  - Lymphedema-associated angiosarcoma also known as lymphangiosarcoma is the commonest type of cutaneous angiosarcoma. Post-mastectomy lymphedema is the most  frequent cause, while chronic filarial lymphedema is one of the most uncommon etiology for development of lymphangiosarcoma. We report a case of a 50 year old  male suffering from chronic filarial lymphedema of right lower extremity, presented with brownish nodules on the right leg, which were diagnosed histopathologically as lymphangiosarcoma.

 

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[546]

TÍTULO / TITLE:  - Radiofrequency ablation for treatment for osteoid osteoma of the scapula using a  new three-dimensional fluoroscopic navigation system.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Orthop Surg Traumatol. 2013 Feb 15.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00590-013-1180-7

AUTORES / AUTHORS:  - Okada K; Myoui A; Hashimoto N; Takenaka S; Moritomo H; Murase T; Yoshikawa H

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan, kokada2433@snow.ocn.ne.jp.

RESUMEN / SUMMARY:  - Osteoid osteoma is a relatively common benign skeletal tumor. The traditional standard treatment has been surgical resection of the nidus. Recently, computed tomography (CT)-guided radiofrequency ablation (RFA) has gained favor as a more precise alternative due to potentially less bone destruction. However, CT-guided  RFA is limited in treatment for osteoid osteoma involving complex anatomic structures such as cervical spine, pelvis, or scapula because of difficulty in approach and proximity to neurovascular structures. To solve this problem, we investigated RFA using a new real-time three-dimensional fluoroscopic navigation  system. We report its technical procedure and use in a rare case of osteoid osteoma of the scapula.

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[547]

TÍTULO / TITLE:  - Complete response of endemic Kaposi sarcoma lesions with high-dose-rate brachytherapy: Treatment method, results, and toxicity using skin surface applicators.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Brachytherapy. 2013 Mar 1. pii: S1538-4721(13)00192-X. doi: 10.1016/j.brachy.2012.09.007.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.brachy.2012.09.007

AUTORES / AUTHORS:  - Kasper ME; Richter S; Warren N; Benda R; Shang C; Ouhib Z

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL. Electronic address: MKasper@brrh.com.

RESUMEN / SUMMARY:  - PURPOSE: To analyze the clinical outcome of Kaposi sarcoma skin lesions treated with high-dose-rate (HDR) brachytherapy in patients with a minimum of 2 years of  followup. METHODS AND MATERIALS: Between February 2006 and July 2008, all patients with Kaposi sarcoma who received 192Ir HDR brachytherapy using a skin surface applicator were evaluated for clinical response. Responses to treatment and toxicity were scored using standard criteria. RESULTS: Sixteen cases were collected. Treatment was delivered in four to six fractions, over a period of approximately 12 days. The specified dose ranged from 24 to 35Gy. Median followup the lesion was 41.4 months. No lesion was greater than 2cm. All patients had a complete response to treatment, with no evidence of local recurrence or tumor progression. Thirteen lesions developed Grade 1 and two lesions had Grade 2 acute skin reactions. One patient developed late skin changes with telangiectasias and  hypopigmentation. CONCLUSIONS: HDR brachytherapy treatment seems to be an effective noninvasive option for patients with small cutaneous Kaposi sarcoma lesions, delivering excellent cosmesis and local control in our small series. Fewer fractions over a shorter period used in our group offer patients more convenience compared with other common regimens. Although HDR is being used more  frequently for many surface applications, additional clinical studies with larger numbers of patients and longer followup are needed to confirm the general impression that it is an excellent option for many patients.

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[548]

TÍTULO / TITLE:  - Leiomyomatosis peritonealis disseminata with formation of endometrial cysts within tumors arising after supracervical laparoscopic hysterectomy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ginekol Pol. 2013 Jan;84(1):68-71.

AUTORES / AUTHORS:  - Bogusiewicz M; Rosinska-Bogusiewicz K; Walczyna B; Drop A; Rechberger T

INSTITUCIÓN / INSTITUTION:  - 2nd Department of Gynaecology, Medica University of Lublin, Lublin, Poland. mbogusiewicz@yahoo.com

RESUMEN / SUMMARY:  - BACKGROUND: Use of morcellation during laparoscopic hysterectomy may result in seeding of uterine tissue throughout the abdominal cavity and development of ‘iatrogenic’ leiomyomatosis peritonealis disseminata. CASE: Two years after a supracervical laparoscopic hysterectomy a 42-year-old parous women presented with abdominal pain and bloating. CT scans and subsequent surgical exploration reveled multiple solid tumors containing cysts filled with altered blood. Histologically  the tumors had characteristic features of a benign leiomyoma with smooth muscle cells infiltrated by endometrial glands. CONCLUSION: Pieces of smooth muscle cell and endometrial uterine tissue lost in the abdominal cavity during morcellation may progress to leiomyomatosis peritonealis disseminata with unusual appearance.

 

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[549]

TÍTULO / TITLE:  - (125)I brachytherapy seeds implantation for inoperable low-grade leiomyosarcoma of inferior vena cava.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Radiol. 2013 Mar;14(2):278-82. doi: 10.3348/kjr.2013.14.2.278. Epub 2013 Feb 22.

            ●● Enlace al texto completo (gratuito o de pago) 3348/kjr.2013.14.2.278

AUTORES / AUTHORS:  - Li Y; Wang Y; Liu B; Li Z; Wang W

INSTITUCIÓN / INSTITUTION:  - Department of Interventional Therapy, The Second Hospital of Shandong University, Jinan 250033, China.

RESUMEN / SUMMARY:  - A 60-year-old female presented with abdominal pain and tenderness of five-day duration. Contrast enhanced CT showed a mass of 9 x 6 x 5.5 cm in size with almost complete obliteration of the inferior vena cava and massive extension to the extravascular space. CT-guided biopsy demonstrated a low-grade leiomyosarcoma. The patient underwent (125)Iodine seeds implantation in two sessions, and another balloon cavoplasty. Abdominal pain and tenderness gradually improved and the patient continues to remain as disease free state for three years after the procedures.

 

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[550]

TÍTULO / TITLE:  - An Intrathoracic Low-Grade Fibromyxoid Sarcoma Arising from the Chest Wall with Massive Pleural Effusion.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2013 Mar 22.

AUTORES / AUTHORS:  - Tominaga Y; Eguchi T; Shiina T; Hamanaka K; Amano J; Asaka S; Yoshida K

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, Shinshu University School of Medicine.

RESUMEN / SUMMARY:  - We herein report a case of an intrathoracic low-grade fibromyxoid sarcoma arising from the chest wall and associated with massive pleural effusion. A 70-year-old man presented with a persistent cough. A chest computed tomography scan revealed  a large mass in the right pleural cavity with massive pleural effusion. No malignant cells were recognized in the pleural effusion by thoracentesis. A malignant soft tissue tumor was suspected, and surgery was performed. The tumor arose from the posterior chest wall and was resected with the connected chest wall. The definitive diagnosis was a low grade fibromyxoid sarcoma. Because the posterior margin of the chest wall was microscopically tumor positive, postoperative irradiation was performed. The patient has now been followed up for 30 months with no evidence of recurrence.

 

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[551]

TÍTULO / TITLE:  - Asymptomatic grade-2 central chondrosarcoma of the distal femur with non-aggressive radiological features.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hong Kong Med J. 2013 Feb;19(1):85-7.

AUTORES / AUTHORS:  - Lam YL; Koljonen PA; Ho WY; Ng TP; Shek TW; Wong JS

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics and Traumatology, Queen Mary Hospital, Pokfulam, Hong  Kong. albertlam2000@yahoo.com

RESUMEN / SUMMARY:  - This paper discusses the case of a 57-year-old man with an incidental finding of  a radiologically non-aggressive chondroid lesion and concomitant osteonecrosis in the left distal femur. The final resected specimen showed a grade-2 chondrosarcoma. This case illustrates that long-term follow-up is necessary for non-aggressive chondroid lesions. If surgical management is considered, resection with an adequate margin is superior to intralesional curettage.

 

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[552]

TÍTULO / TITLE:  - Peripheral fibroma obstructing the eruption pathway.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Dent Res. 2012 Sep-Oct;23(5):677-9. doi: 10.4103/0970-9290.107397.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0970-9290.107397

AUTORES / AUTHORS:  - Shetty P; Padmanabhan V; Kavitha PR; Thomas H

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric and Preventive Children Dentistry, Triveni Institute of Dental Sciences and Research Centre, Bilaspur, Chhattisgarh, India.

RESUMEN / SUMMARY:  - Reactive hyperplasias comprise a group of fibrous connective tissue lesions that  commonly occur in oral mucosa secondary to injury. Peripheral fibroma is also a type of reactive hyperplasia. Peripheral fibroma is a reactive hyperplastic mass  that occurs on the gingiva and is derived from connective tissue of the submucosa or periodontal ligament. It may occur at any age, although it does have a predilection for young adults. Females develop these lesions more commonly than do males. Here, we are presenting a case report of a child who is 6 years old and presented to us with a swelling in the lower anterior region which was providing  discomfort to the child and also was obstructing the eruption pathway of the permanent central incisor in the region. The lesion was surgically excised.

 

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[553]

TÍTULO / TITLE:  - FDG PET or PET/CT in Evaluation of Renal Angiomyolipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Radiol. 2013 Mar;14(2):337-42. doi: 10.3348/kjr.2013.14.2.337. Epub 2013 Feb 22.

            ●● Enlace al texto completo (gratuito o de pago) 3348/kjr.2013.14.2.337

AUTORES / AUTHORS:  - Lin CY; Chen HY; Ding HJ; Yen KY; Kao CH

INSTITUCIÓN / INSTITUTION:  - Department of Nuclear Medicine, Show Chwan Memorial Hospital, Changhua 500, Taiwan.

RESUMEN / SUMMARY:  - OBJECTIVE: Angiomyolipoma is the most common benign kidney tumor. However, literature describing FDG PET findings on renal angiomyolipoma (AML) is limited.  This study reports the FDG PET and PET/CT findings of 21 cases of renal AML. MATERIALS AND METHODS: The study reviews FDG PET and PET/CT images of 21 patients diagnosed with renal AML. The diagnosis is based on the classical appearance of an AML on CT scan with active surveillance for 6 months. The study is focused on  the observation of clinical and radiographic features. RESULTS: Six men and 15 women were included in our study. The mean age of the patients was 57.14 +/- 9.67 years old. The mean diameter of 21 renal AML on CT scans was 1.76 +/- 1.00 cm (Min: 0.6 cm; Max: 4.4 cm). CT scans illustrated renal masses typical of AMLs, and the corresponding FDG PET scans showed minimal FDG activities in the area of  the tumors. None of the 21 AMLs showed a maximum standardized uptake value (SUVmax) greater than 1.98. No statistically significant correlation was present  between SUVmax and tumor size. CONCLUSION: Renal AMLs demonstrate very low to low uptake on FDG PET and PET/CT imaging in this study. When a fat-containing tumor in the kidney is found on a CT scan, it is critical to differentiate an AML from  a malignant tumor including an RCC, liposarcoma, and Wilms tumor. This study suggests that FDG PET or PET/CT imaging is useful for differentiating a renal AML from a fat-containing malignant tumor.

 

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[554]

TÍTULO / TITLE:  - Chloroma of perianal region masquerading as perianal abscess.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Dermatol. 2013 Jan;58(1):85. doi: 10.4103/0019-5154.105326.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0019-5154.105326

AUTORES / AUTHORS:  - Sen R; Singh S; Qury MS; Marwah S; Aggarwal G; Singla S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India.

RESUMEN / SUMMARY:  - Chloroma, also called granulocytic sarcoma (GS) or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but its appearance may precede the onset of leukaemia. The presence of a chloroma is certainly a sign of poor prognosis. We report a case of chloroma in a middle aged female without a prior history of leukemia in the perianal skin region with clinical diagnosis of perianal abscess. When there is no concomitant leukaemia, diagnosis of chloroma may be difficult. Differential diagnoses include acute lymphoblastic leukemia, large cell NHL, lymphoblastic lymphoma, Ewing’s sarcoma and cutaneous T cell lymphoma.

 

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[555]

TÍTULO / TITLE:  - Intrathoracic Thyroid Solitary Fibrous Tumor Presenting with Respiratory Failure.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2013 Feb 28.

AUTORES / AUTHORS:  - Lin MW; Wu CT; Lee YH; Chang YL

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, National Taiwan University Hospital Yun-Lin Branch, Yunlin, Taiwan.

RESUMEN / SUMMARY:  - Solitary fibrous tumor (SFT) is an uncommon mesenchymal neoplasm that arises primarily from the pleura, but recognized also in other tissues. SFT in the thyroid gland is extremely rare. Here we presented the second reported SFT arising in an intrathoracic goiter. The88-year-old woman was referred with a huge goiter involving upper mediastinum accompanied by airway obstruction and tracheostomy. The patient underwent a left subtotal thyroidectomy, which revealed a SFT. No recurrence was noted during 3 years of follow-up.

 

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[556]

TÍTULO / TITLE:  - Cutaneous lymphangiosarcoma following chronic lymphedema of filarial origin.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Dermatol. 2013 Jan;58(1):68-70. doi: 10.4103/0019-5154.105314.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0019-5154.105314

AUTORES / AUTHORS:  - Acharya AS; Sulhyan K; Ramteke R; Kunghadkar V

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, 2 Floor, RCSM Government Medical College and CPR Hospital, Kolhapur, India.

RESUMEN / SUMMARY:  - We are reporting a case of 36 yr old female with chronic filarial lymphedema of both legs. Subsequently she developed lymphangiosarcoma of her left leg which was confirmed histologically and on immunohistochemistry. Only three more cases of lymphagiosarcoma occurring in patients with filarial lymphedema are reviewed from available literature.

 

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[557]

TÍTULO / TITLE:  - Angioleiomyoma of the superficial palmar arterial arch.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hand Surg. 2013;18(1):121-3. doi: 10.1142/S0218810413720106.

            ●● Enlace al texto completo (gratuito o de pago) 1142/S0218810413720106

AUTORES / AUTHORS:  - Kobayashi K; Otsuka H; Fukasawa K

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Kanto Rosai Hospital, Kawasaki City, 211-8510, Japan. kck829@pa3.so-net.ne.jp

RESUMEN / SUMMARY:  - Angioleiomyomas are benign solitary soft-tissue tumors that originate from the vascular smooth muscle of vessels and rarely occur in the hand. Pain and tenderness are the only clinical characteristics. This report presents a rare case of angioleiomyoma arising from both the superficial palmar arch and a concomitant vein of the artery. The MRI findings lack specific radiological features. However, three-dimensional magnetic resonance angiography demonstrated  the existence of a relationship between the tumor and its feeding vessels. The diagnosis was made after a histopathological study of the tumor. Adequate collateral circulation should be confirmed both before and during surgery if the  lesion occurs within an artery. Angioleiomyoma should therefore be included in the differential diagnosis of painful vascular tumors with no neurological findings in the hand.

 

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[558]

TÍTULO / TITLE:  - Giant intrapericardial lipoma: An unusual cause of dyspnoea.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian Heart J. 2013 Jan-Feb;65(1):104-6. doi: 10.1016/j.ihj.2012.12.008. Epub 2012 Dec 26.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ihj.2012.12.008

AUTORES / AUTHORS:  - Vijay SK; Dwivedi SK; Chandra S; Saran RK

INSTITUCIÓN / INSTITUTION:  - Senior Resident, Department of Cardiology, King George Medical University (KGMU)  Chowk, Lucknow 226003, U.P., India. Electronic address: skvijay1980@rediffmail.com.

RESUMEN / SUMMARY:  - The pericardial lipomas are rare benign cardiac tumors. The clinical presentation of these cardiac neoplasms varies according to the site of growth. We describe here a case of massive intrapericardial lipoma leading to severe dyspnea, its diagnostic work up and briefly review the existing literature of this uncommon disorder. The patient underwent successful surgical resection of the tumor with complete alleviation of the symptoms.

 

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[559]

TÍTULO / TITLE:  - Modeling of the kinetics of vitamin D3 in osteoblastic cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Math Biosci Eng. 2013 Apr 1;10(2):319-44. doi: 10.3934/mbe.2013.10.319.

AUTORES / AUTHORS:  - Gilbert RP; Guyenne P; Liu Y

INSTITUCIÓN / INSTITUTION:  - Department of Mathematical Sciences, University of Delaware, Newark, DE 19716, United States. gilbert@math.udel.edu.

RESUMEN / SUMMARY:  - A one-dimensional model for the transport of vitamin D3 in an osteoblast cell is  proposed, from its entry through the membrane to its activation of RANKL synthesis in the nucleus. In the membrane and cytoplasm, the transport of D3 and  RANKL is described by a diffusion process, while their interaction in the nucleus is modeled by a reaction-diffusion process. For the latter, an integral equation  involving the boundary conditions, as well as an asymptotic solution in the regime of small concentrations, are derived. Numerical simulations are also performed to investigate the kinetics of D3 and RANKL through the entire cell. Comparison between the asymptotics and numerics in the nucleus shows an excellent agreement. To our knowledge, this is the first time, albeit using a simple model, a description of the complete passage of D3 through the cell membrane, the cytoplasm, into the cell nucleus, and finally the production of RANKL with its passage to the exterior of the cell, has been modeled.

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[560]

TÍTULO / TITLE:  - Cobalt chloride inhibits tumor formation in osteosarcoma cells through upregulation of HIF-1alpha

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Mar;5(3):911-916. Epub 2013 Jan 10.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2013.1127

AUTORES / AUTHORS:  - Zhang B; Guo W; Yu L; Wang F; Xu Y; Liu Y; Huang C

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan 430060, P.R.  China.

RESUMEN / SUMMARY:  - The exact effect of hypoxia on cancer development is controversial. The present study investigates the ability of osteosarcoma to form tumors in the hypoxic microenvironment induced by CoCl(2). MG63 human osteosarcoma cells were cultured  with different concentrations (0, 150 and 300 muM) of CoCl(2) for 24 h to simulate hypoxia in vitro. The expression of hypoxia-inducible factor (HIF)-1alpha was analyzed by western blotting. The proliferation and drug resistance of MG63 cells were examined using the CCK-8 assay, the apoptosis rate  was detected by flow cytometry, the ability to form spheroids was assessed by a sarcosphere culture system and invasiveness was determined by a vertical invasion assay. A transplantation assay was used to evaluate the ability to form tumors in vivo. Our results showed that the proliferation of MG63 cells was inhibited by treatment with CoCl(2), while no effect on drug toxicity was observed. The apoptotic rate was increased in a dose-dependent manner, the ability to form sarcospheroids was suppressed, the invasiveness was inhibited and the expression  of HIF-1alpha was upregulated following CoCl(2) treatment. We also found that the ability to form tumors in vivo was inhibited. In conclusion, we provide strong evidence that CoCl(2) has the ability to inhibit osteosarcoma development; the mechanism may be related to the hypoxic microenvironment and HIF-1alpha may be a  critical regulatory factor.

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[561]

TÍTULO / TITLE:  - Salient features of mesenchymal stem cells-implications for Ewing sarcoma modeling.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Front Oncol. 2013;3:24. doi: 10.3389/fonc.2013.00024. Epub 2013 Feb 25.

            ●● Enlace al texto completo (gratuito o de pago) 3389/fonc.2013.00024

AUTORES / AUTHORS:  - Monument MJ; Bernthal NM; Randall RL

INSTITUCIÓN / INSTITUTION:  - Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, University of Utah Salt Lake City, UT, USA.

RESUMEN / SUMMARY:  - Despite a heightened appreciation of the many defining molecular aberrations in Ewing sarcoma, the cooperative genetic environment and permissive cell of origin  essential for EWS/ETS-mediated oncogenesis remain elusive. Consequently, inducible animal and in vitro models of Ewing sarcoma from a native cellular context are unable to fully recapitulate malignant transformation. Despite these  shortcomings, human, and murine mesenchymal stem cells (MSCs) are the closest working in vitro systems available. MSCs are tolerant of ectopic EWS/FLI expression, which is accompanied by a molecular signature most similar to Ewing sarcoma. Whether MSCs are the elusive cell of origin or simply a tolerant platform of the EWS/FLI transcriptome, these cells have become an excellent molecular tool to investigate and manipulate oncogenesis in Ewing sarcoma. Our understanding of the biological complexity and heterogeneity of human MSCs (hMSCs) has increased substantially over time and as such, appreciation and utilization of these salient complexities may greatly enhance the efficient use of these cells as surrogate models for Ewing sarcoma tumorigenesis.

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[562]

TÍTULO / TITLE:  - UV-irradiated 7-dehydrocholesterol coating on polystyrene surfaces is converted to active vitamin D by osteoblastic MC3T3-E1 cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Photochem Photobiol Sci. 2013 Mar 28.

            ●● Enlace al texto completo (gratuito o de pago) 1039/c3pp50025j

AUTORES / AUTHORS:  - Satue M; Cordoba A; Ramis JM; Monjo M

INSTITUCIÓN / INSTITUTION:  - Department of Fundamental Biology and Health Sciences, Research Institute on Health Sciences (IUNICS), University of Balearic Islands, España. marta.monjo@uib.es.

RESUMEN / SUMMARY:  - The aim of the present study was to determine the effects of UV irradiation on the conversion of 7-dehydrocholesterol (7-DHC), which has been coated onto a polystyrene surface, to cholecalciferol (D3), and the resulting effect on the formation of vitamin D (1,25-D3) by MC3T3-E1 cells. The changes in gene expression of the enzymes regulating its hydroxylation, Cyp27b1 and Cyp27a1, were monitored as well as the net effect of the UV-treated 7-DHC coating on cell viability and osteoblast differentiation. MC3T3-E1 cells were found to express the enzymes required for synthesizing active 1,25-D3, and we found a dose-dependent increase in the production of both 25-D3 and 1,25-D3 levels for UV-activated 7-DHC samples unlike UV-untreated ones. Cell viability revealed no cytotoxic effect for any of the treatments, but only for the highest dose of 7-DHC (20 nmol per well) that was UV-irradiated. Furthermore, osteoblast differentiation was increased in cells treated with some of the higher doses of 7-DHC when UV-irradiated, as shown by collagen-I, osterix and osteocalcin relative mRNA levels. The conversion of 7-DHC to preD3 exogenously by UV irradiation and later to 25-D3 by MC3T3-E1 cells was determined for the optimum 7-DHC dose (0.2 nmol per well), i.e. 8.6 +/- 0.7% of UV-activated 7-DHC was converted to preD3 and 6.7 +/- 2.8% of preD3 was finally converted to 25-D3 under the conditions studied. In conclusion, we demonstrate that an exogenous coating of 7-DHC, when UV-irradiated, can be used to endogenously produce active vitamin  D. We hereby provide the scientific basis for UV-activated 7-DHC coating as a feasible approach for implant therapeutics focused on bone regeneration.

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[563]

TÍTULO / TITLE:  - Histological characterization of bone marrow in ectopic bone, induced by devitalized Saos-2 human osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Clin Exp Med. 2013;6(2):119-25. Epub 2013 Jan 26.

AUTORES / AUTHORS:  - Nahar NN; Tague SE; Wang J; Danley M; Garimella R; Anderson HC

INSTITUCIÓN / INSTITUTION:  - Departments of Pathology and Laboratory Medicine, The University of Kansas Medical Center Kansas City, KS, USA.

RESUMEN / SUMMARY:  - Devitalized Saos-2, cultured human osteosarcoma cells, or guanidinium-hydrochloride (GuHCl) extracts of these cells, induce ectopic bone and marrow formation when implanted subcutaneously in Nu/Nu mice. The aim of the  present study was to characterize the bone marrow induced by Saos-2 cell extracts, specifically to determine which of the four major hematopoietic cell lineages: erythropoietic, granulopoietic, lymphopoietic and megakaryocytic, are induced by Saos-2 cell derivatives. METHODS: Immunohistochemical localization of  specific antigens was used to determine the presence of each major cell type (glycophorin A for erythropoietic, neutrophil elastase for granulopoietic, factor-VIII related antigen for megakaryocytes, and CD79a for B lymphocytes). RESULTS: Standard H & E stains confirmed the presence of normally organized apparently complete bone marrow within all newly induced bone at 3 weeks post-implantation of devitalized Saos-2 cells. Immunohistochemistry confirmed the presence of erythropoietic cells, granulopoietic cells, megakaryocytes and B lymphocytes in the ectopic marrow. CONCLUSION: Saos-2 cells (freeze-dried) or their extracts, implanted subcutaneously into Nu/Nu mice, can induce normal marrow that is host-derived, and contains all major hematopoietic cell lineages.  Clinical Significance: Saos-2 induced marrow could potentially restore deficient  marrow and promote bone repair.

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[564]

TÍTULO / TITLE:  - Endoscopic endonasal approach for the treatment of a large clival giant cell tumor complicated by an intraoperative internal carotid artery rupture.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Manag Res. 2013;5:21-4. doi: 10.2147/CMAR.S38768. Epub 2013 Jan 30.

            ●● Enlace al texto completo (gratuito o de pago) 2147/CMAR.S38768

AUTORES / AUTHORS:  - Iacoangeli M; Di Rienzo A; Re M; Alvaro L; Nocchi N; Gladi M; De Nicola M; Scerrati M

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Universita Politecnica delle Marche, Umberto I General Hospital, Ancona, Italy.

RESUMEN / SUMMARY:  - Giant cell tumors (GCTs) are primary bone neoplasms that rarely involve the skull base. These lesions are usually locally aggressive and require complete removal,  including the surrounding apparently healthy bone, to provide the best chance of  cure. GCTs, as well as other lesions located in the clivus, can nowadays be treated by a minimally invasive fully endoscopic extended endonasal approach. This approach ensures a more direct route to the craniovertebral junction than other possible approaches (transfacial, extended lateral, and posterolateral approaches). The case reported is a clival GCT operated on by an extended endonasal approach that provides another contribution on how to address one of the most feared complications attributed to this approach: a massive bleed due to an internal carotid artery injury.

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[565]

TÍTULO / TITLE:  - Recurrent spontaneous pneumothorax in a 42 years old woman with pulmonary lymphangioleiomyomatosis: insights and pitfalls of the surgical treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Med Res. 2013 Feb;5(1):70-4. doi: 10.4021/jocmr1170w. Epub 2013 Jan 11.

            ●● Enlace al texto completo (gratuito o de pago) 4021/jocmr1170w

AUTORES / AUTHORS:  - Spiliopoulos K; Tsantsaridou A; Papamichali R; Kimpouri K; Salemis NS; Koukoulis GK; Tsilimingas NB

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic and Cardiovascular Surgery, University of Thessaly, Larissa, Greece.

RESUMEN / SUMMARY:  - Lymphangioleiomyomatosis (LAM) is a rare disease that occurs predominantly in females between the ages of 30 and 50 years and is clinically characterized by progressive dyspnoea on exertion, recurrent pneumothoraces, abdominal and thoracic lymphadenopathy, as well tumors-like angiomyolipomas and lymphangiomyomas. We present the case of a 42-year-old woman, who developed recurrent pneumothoraces and was subsequently diagnosed with LAM. Although pneumothorax is a common complication of the disease, its optimal approach to treatment and prevention remains unclear. Chemical or surgical pleurodesis are often performed in order to prevent recurrence, but may predispose to perioperative complications in the event of future lung transplantation.

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[566]

TÍTULO / TITLE:  - Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Orthop Traumatol. 2013 Mar 6.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10195-013-0230-6

AUTORES / AUTHORS:  - Campanacci DA; Scoccianti G; Franchi A; Roselli G; Beltrami G; Ippolito M; Caff G; Frenos F; Capanna R

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Oncology and Reconstructive Surgery, Azienda Ospedaliera Universitaria Careggi, Florence, Italy, campanaccid@gmail.com.

RESUMEN / SUMMARY:  - BACKGROUND: Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. MATERIALS AND METHODS: A retrospective review of 85 patients was performed (61 females and 24 males, age range 20-76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients  with aggressive radiological patterns were treated with wide resection. RESULTS:  Mean follow-up was 67 months (range 24-206 months). Two patients developed local  recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. CONCLUSIONS: Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. Wide resection, following surgical principles of malignant bone tumors, should be considered only when aggressive biologic behavior is evident on imaging.

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[567]

TÍTULO / TITLE:  - Solitary enchondroma presenting with an intra-articular comminuted fracture treated with ligamentaxis and percutaneous curettage.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Hand Surg Eur Vol. 2013 Feb 6.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1753193413476224

AUTORES / AUTHORS:  - Karthik K; Compson J

INSTITUCIÓN / INSTITUTION:  - Upper Limb Unit, Department of Orthopaedic Surgery, King’s College Hospital, London, UK.

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[568]

TÍTULO / TITLE:  - Radiologically guided percutaneous cryotherapy for soft tissue tumours: A promising treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Interv Imaging. 2013 Apr;94(4):364-70. doi: 10.1016/j.diii.2013.02.001. Epub 2013 Mar 11.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.diii.2013.02.001

AUTORES / AUTHORS:  - Cornelis F; Havez M; Lippa N; Al-Ammari S; Verdier D; Carteret T; Amoretti N; Gangi A; Palussiere J; Hauger O; Grenier N

INSTITUCIÓN / INSTITUTION:  - Adult Diagnostic and Interventional Imaging Department, hopital Pellegrin, CHU de Bordeaux, place Amelie-Raba-Leon, 33076 Bordeaux, France. Electronic address: francois.cornelis@chu-bordeaux.fr.

RESUMEN / SUMMARY:  - Studies of percutaneous cryotherapy in the treatment of benign or malignant soft  tissue tumours are rare and mainly involve small populations. Nevertheless, results show cryotherapy’s potential in terms of local control of tumours, analgesic efficacy, reduced intra- and postoperative complications, and reduction in the length of convalescence after the procedure. The objective of this update  is to set out the short-term prospects for this technique in the treatment of soft tissue tumours, so that it may be more widely offered in these indications.

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[569]

TÍTULO / TITLE:  - Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2013;2013:153640. doi: 10.1155/2013/153640. Epub 2013 Jan 14.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/153640

AUTORES / AUTHORS:  - Holzapfel BM; Chhaya MP; Melchels FP; Holzapfel NP; Prodinger PM; von Eisenhart-Rothe R; van Griensven M; Schantz JT; Rudert M; Hutmacher DW

INSTITUCIÓN / INSTITUTION:  - Regenerative Medicine Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4049, Australia ; Department of Orthopaedic Surgery, Konig-Ludwig-Haus, Orthopaedic Center for Musculoskeletal Research, University of Wurzburg, Brettreich Strasse 11, 97072 Wurzburg, Germany.

RESUMEN / SUMMARY:  - Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infection. Therefore, reconstruction of these defects is still one of the most demanding procedures in orthopaedic surgery. The constraints of common treatment  strategies have triggered a need for new therapeutic concepts to design and engineer unparalleled structural and functioning bone grafts. To satisfy the need for long-term repair and good clinical outcome, a paradigm shift is needed from methods to replace tissues with inert medical devices to more biological approaches that focus on the repair and reconstruction of tissue structure and function. It is within this context that the field of bone tissue engineering can offer solutions to be implemented into surgical therapy concepts after resection  of bone and soft tissue sarcoma. In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology.

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[570]

TÍTULO / TITLE:  - Quasi-Complete Response of Classic Kaposi’s Sarcoma Treated with Weekly Paclitaxel.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol Med. 2013;2013:196878. doi: 10.1155/2013/196878. Epub 2013 Feb 14.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/196878

AUTORES / AUTHORS:  - Benbrahim Z; Arifi S; Benhammane H; Inani K; Gallouj S; Meziane M; Mernissi FZ; Mellas N; El Mesbahi O

INSTITUCIÓN / INSTITUTION:  - Medical Oncology, Hassan II University Hospital, P.O. Box 8743, Fes, Morocco.

RESUMEN / SUMMARY:  - Classic Kaposi’s sarcoma (CKS) is a subtype that traditionally occurs in elderly  HIV-negative males of Mediterranean origin. Patients with CKS characteristically  present with skin lesions in the distal extremities. Involvement of the viscera is uncommon but may occur in the late stages of the disease. Patients with extensive KS can be treated with systemic chemotherapy. A number of drugs approved for treatment of AIDS-associated KS, especially Paclitaxel, have activity against CKS after failure of prior therapy. We report a patient treated  with weekly Paclitaxel, as initial chemotherapy, for CKS presenting with multiple visceral involvement and having a contraindication for Bleomycin. The patient had quasi-complete response after three months of chemotherapy suggesting that weekly Paclitaxel might be effective as a first-line therapy for classical type KS with  visceral involvement.

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[571]

TÍTULO / TITLE:  - Targeted treatment for advanced soft tissue sarcoma: profile of pazopanib.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Onco Targets Ther. 2013;6:217-22. doi: 10.2147/OTT.S32200. Epub 2013 Mar 18.

            ●● Enlace al texto completo (gratuito o de pago) 2147/OTT.S32200

AUTORES / AUTHORS:  - Rajendra R; Jones RL; Pollack SM

INSTITUCIÓN / INSTITUTION:  - University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

RESUMEN / SUMMARY:  - Soft tissue sarcomas comprise approximately 1% of all adult solid malignancies. While chemotherapy is the mainstay of treatment for patients with metastatic or inoperable disease, overall survival for these patients is approximately 12 months, highlighting the need for novel agents. Both laboratory and clinical data have suggested that antiangiogenic agents may have a role in the treatment of soft tissue sarcomas. Pazopanib is a multitargeted receptor tyrosine kinase inhibitor with antiangiogenic activity. The randomized, double-blind, placebo-controlled, Phase III PALETTE (pazopanib for metastatic soft-tissue sarcoma) study demonstrated improved progression-free survival in patients receiving pazopanib compared with placebo. In this review, we discuss the rationale and clinical evidence for the use of pazopanib in the treatment of metastatic and inoperable soft tissue sarcomas.

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[572]

TÍTULO / TITLE:  - Genome-wide analyses of sarcoma: implications for future treatment options.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Future Oncol. 2013 Mar;9(3):307-10. doi: 10.2217/fon.13.1.

            ●● Enlace al texto completo (gratuito o de pago) 2217/fon.13.1

AUTORES / AUTHORS:  - Schiffman JD

INSTITUCIÓN / INSTITUTION:  - Pediatric Hematology Oncology, Center for Children’s Cancer Research, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USA. joshua.schiffman@hci.utah.edu.

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[573]

TÍTULO / TITLE:  - Cell-based small-molecule compound screen identifies fenretinide as potential therapeutic for translocation-positive rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e55072. doi: 10.1371/journal.pone.0055072. Epub 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0055072

AUTORES / AUTHORS:  - Herrero Martin D; Boro A; Schafer BW

INSTITUCIÓN / INSTITUTION:  - Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich, Zurich, Switzerland.

RESUMEN / SUMMARY:  - A subset of paediatric sarcomas are characterized by chromosomal translocations encoding specific oncogenic transcription factors. Such fusion proteins represent tumor specific therapeutic targets although so far it has not been possible to directly inhibit their activity by small-molecule compounds. In this study, we hypothesized that screening a small-molecule library might identify already existing drugs that are able to modulate the transcriptional activity of PAX3/FOXO1, the fusion protein specifically found in the pediatric tumor alveolar rhabdomyosarcoma (aRMS). Towards this end, we established a reporter cell line based on the well characterized PAX3/FOXO1 target gene AP2ss. A library enriched  in mostly FDA approved drugs was screened using specific luciferase activity as read-out and normalized for cell viability. The most effective inhibitor identified from this screen was Fenretinide. Treatment with this compound resulted in down-regulation of PAX3/FOXO1 mRNA and protein levels as well as in reduced expression of several of its direct target genes, but not of wild-type FOXO1, in a dose- and time-dependent manner. Moreover, fenretinide induced reactive oxygen species and apoptosis as shown by caspase 9 and PARP cleavage and upregulated miR-9. Importantly, it demonstrated a significant anti-tumor effect in vivo. These results are similar to earlier reports for two other pediatric tumors, namely neuroblastoma and Ewing sarcoma, where fenretinide is under clinical development. Our results suggest that fenretinide might represent a novel treatment option also for translocation-positive rhabdomyosarcoma.

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[574]

TÍTULO / TITLE:  - Compound In Vivo Inactivation of Pml and p53 Uncovers a Functional Interaction in Angiosarcoma Suppression.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genes Cancer. 2012 Sep;3(9-10):599-603. doi: 10.1177/1947601912473604.

            ●● Enlace al texto completo (gratuito o de pago) 1177_1947601912473604 [pii

            ●● Enlace al texto completo (gratuito o de pago) 1177/1947601912473604

AUTORES / AUTHORS:  - Papa A; Cordon-Cardo C; Bernardi R; Pandolfi PP

INSTITUCIÓN / INSTITUTION:  - Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA ; Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

RESUMEN / SUMMARY:  - The promyelocytic leukemia (PML) tumor suppressor gene was initially identified as part of the t(15:17) chromosomal translocation associated with acute promyelocytic leukemia (APL). The PML protein is responsible for the assembly and function of characteristic nuclear domains known as PML-nuclear bodies (PML-NBs), which have been implicated in a variety of cellular functions, including growth suppression, apoptosis, and cellular senescence. PML’s many roles have been linked, at least in part, to its functional interaction with the tumor suppressor p53. It has been shown that PML favors both p53 accumulation and transcriptional  activity; in turn, PML expression is directly regulated by p53, and this reciprocal regulation contributes to p53-mediated apoptosis and senescence. Nevertheless, genetic proof and in vivo assessment of the relevance of this functional crosstalk are still missing. Here we show that complete Pml inactivation, in a context of p53 heterozygosity, redistributes and expands the tumor spectrum leading to the formation of angiosarcomas and increased lymphomagenesis. Importantly, we find that Pml inactivation decreases the rate of loss of heterozygosity (LOH) in the remaining p53 allele, revealing the relevancy of p53 haploinsufficiency to tumorigenesis. Our results thus lend in vivo genetic support to the importance of the crosstalk between these two critical tumor suppressor genes.

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[575]

TÍTULO / TITLE:  - Ewing sarcoma of the bone in children under 6 years of age.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e53223. doi: 10.1371/journal.pone.0053223. Epub 2013 Jan 31.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0053223

AUTORES / AUTHORS:  - De Ioris MA; Prete A; Cozza R; Podda M; Manzitti C; Pession A; Schiavello E; Contoli B; Balter R; Fagioli F; Bisogno G; Amoroso L; Locatelli F; Luksch R

INSTITUCIÓN / INSTITUTION:  - Haematology-Oncology Department, Ospedale Pediatrico Bambino Gesu-IRCCS, Rome, Italy.

RESUMEN / SUMMARY:  - BACKGROUND: Ewing Sarcoma Family Tumours (ESFT) are rare in early childhood. The  aim of this study was to report the clinical characteristics and outcome of children under 6 years of age affected by ESFT of the bone in Italy. METHODS: The records of all the children diagnosed with osseous ESFT in centres members of the Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP) from 1990 to  2008 were reviewed. The Kaplan-Meier method was used for estimating overall and progression-free survival (OS, PFS) curves; multivariate analyses were performed  using Cox proportional hazards regression model. RESULTS: This study includes 62  patients. An axial primary localization was present in 66% of patients, with the  primary site in the chest wall in 34%. Fourteen (23%) patients presented metastatic disease. The 5-year OS and PFS were 73% (95% confidence interval, CI,  58-83%) and 72% (95% CI 57-83%) for patients with localized disease and 38% (95%  CI 17-60%) and 21% (95% CI 5-45%) for patients with metastatic disease. Metastatic spread, skull/pelvis/spine primary localization, progression during treatment and no surgery predicted worse survival (P<0.01), while patients treated in the last decade had better survival (P = 0.002). In fact, the 5-year OS and PFS for patients diagnosed in the period 2000-2008 were 89% (95% CI 71-96%) and 86% (95% CI 66-94%), respectively. CONCLUSION: The axial localization is the most common site of ESFT in pre-scholar children. Patients treated in the  most recent period have an excellent outcome.

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[576]

TÍTULO / TITLE:  - Clinical and pathological features of intradural retroclival chordoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World Neurosurg. 2013 Feb 13. pii: S1878-8750(13)00314-8. doi: 10.1016/j.wneu.2012.12.037.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.wneu.2012.12.037

AUTORES / AUTHORS:  - Wang L; Wu Z; Tian K; Li G; Zhang J

INSTITUCIÓN / INSTITUTION:  - Dept Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, P R China Tiantan Xili 6, Dongcheng District, Beijing, 100050, P R China. Electronic address: saintage7@126.com.

RESUMEN / SUMMARY:  - OBJECTIVE: The aim of this study was to investigate the clinical and pathological characteristics of primary intradural retroclival chordoma and improve the understanding of this rare disease. METHODS: A retrospective study was conducted  on 6 cases of intradural chordoma in the retroclival region, which underwent surgery and were confirmed by pathology and imaging. Expression of Brachyury, Galectin-3 and Ki-67 in paraffin-embedded sections of the specimens was detected  by SP immunohistochemistry. RESULTS: Lesions were located in the subdural prepontine cistern. CT scan showed that the bone of the skull base was not destructed and MRI findings were variable, resulting in a misdiagnosis of 50% of  the cases in the preoperative imaging. By pathology, all the 6 cases were classified into the classical subtype. They presented a strong positive staining  for Brachyury and Galectin-3, and the Ki-67 labeling index was between 2.5% and 8.2%. Three cases presented no signs of recurrence or regrowth, while that ocurred at 7 approximately 14 months after initial surgery in the other 3 cases,  2 of which died of this disease. CONCLUSIONS: Our study suggests that a positive  staining for Brachyury, Galectin-3 and Ki-67 would be helpful for differential diagnosis, discriminating intradural retroclival chordoma from EP and chordoid meningioma. Additionally, it shows that within intradural retroclival chordoma there are significant prognostic differences. Tumors with an abundant blood supply, flake-like cellular arrangement and a Ki-67 labeling index above 5% belong to a rapid-growth type and are prone to short-term recurrence and poorer prognosis.

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[577]

TÍTULO / TITLE:  - Systemic therapy in primary angiosarcoma of the spleen.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Rare Tumors. 2012 Oct 10;4(4):e55. doi: 10.4081/rt.2012.e55. Epub 2012 Nov 13.

            ●● Enlace al texto completo (gratuito o de pago) 4081/rt.2012.e55

AUTORES / AUTHORS:  - Ferreira BP; Rodler ET; Loggers ET; Pollack SM; Jones RL

INSTITUCIÓN / INSTITUTION:  - School of Medicine, Federal University of Rio Grande do Sul, RS, Brazil;

RESUMEN / SUMMARY:  - Primary splenic angiosarcoma is a very rare neoplasm with a high propensity for metastatic disease and poor prognosis. There is a paucity of literature concerning this specific sarcoma subtype and the role of systemic therapy is not  well defined. A retrospective review of the prospectively maintained University of Washington/Seattle Cancer Care Alliance Sarcoma Unit database was performed to identify patients with splenic angiosarcoma treated between 2007 and 2012. In total there were 19 patients with angiosarcoma treated at the Seattle Cancer Care Alliance from 2007 to 2012. The number of patients with splenic angiosarcoma was  2 (11%). The first patient was a woman aged 57 years who was referred with metastatic splenic angiosarcoma to the liver, post-splenectomy. She was treated with 4 cycles of weekly paclitaxel prior to metastatic resection and 4 cycles of  the same drug in an adjuvant scenario, achieving a pathological complete response to treatment. She is alive and on third-line systemic therapy. The second patient was a male patient aged 30 years who presented with metastatic high-grade splenic angiosarcoma and was treated with 3 lines of systemic therapy, including doxorubicin, paclitaxel and gemcitabine+docetaxel, but developed a gastrointestinal metastasis with subsequent gastrointestinal bleeding. Splenic angiosarcoma is a very rare neoplasm. Surgery remains the mainstay of management  for localized disease. Paclitaxel administered weekly proved to be well-tolerated and resulted in a good radiological response in one of our patients, enabling resection of metastatic disease. Durable clinical benefit can be achieved in metastatic splenic angiosarcoma with multi modality management.

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[578]

TÍTULO / TITLE:  - Chondrosarcoma of the petrous bone: a challenging clinical entity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Head Neck Oncol. 2013 Feb 6;5(2):13.

AUTORES / AUTHORS:  - Maslehaty H; Petridis A; Kinzel A; Binay Y; Scholz M

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Klinikum Duisburg, Academic Teaching Hospital of University Essen-Duisburg, Germany * Corresponding author dagger These authors contributed equally to this study.

RESUMEN / SUMMARY:  - Skull base chondrosarcomas are challenging lesions to treat. In this manuscript,  we present a brief overview about this clinical entity. Furthermore, we present an illustrated case with chondrosarcoma of the petrous bone and highlight microsurgical treatment options.

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[579]

TÍTULO / TITLE:  - Clinical, histological, and immunohistochemical features of a mandibular metastasis from a primary cardiac angiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar 16. pii: S2212-4403(13)00005-9. doi: 10.1016/j.oooo.2012.12.017.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.oooo.2012.12.017

AUTORES / AUTHORS:  - Fernandes CP; Oliveira FA; Costa FW; Patrocinio RM; Mota MR; Alves AP; Sousa FB

INSTITUCIÓN / INSTITUTION:  - Master Student in Dentistry (Stomatology), Department of Stomatology and Oral Pathology, School of Dentistry, Federal University of Ceara. Electronic address:  clarissa_pf@hotmail.com.

RESUMEN / SUMMARY:  - Primary cardiac angiosarcoma is an extremely rare malignant tumor. Distant metastases are common at the time of diagnosis but have never been reported in the jaw. A 45-year-old female patient with primary cardiac angiosarcoma was referred for dental care due to pain in the mandibular alveolar ridge. Oral examination revealed a red-violet lesion that was soft on palpation and had been  present for 3 months. Histological analysis confirmed the diagnosis of metastatic cardiac angiosarcoma. The patient died of multiple metastases.

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[580]

TÍTULO / TITLE:  - Clinical Presentation of Uterine Fibroids in Nnewi, Nigeria: A 5-year Review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Med Health Sci Res. 2012 Jul;2(2):114-8. doi: 10.4103/2141-9248.105656.

            ●● Enlace al texto completo (gratuito o de pago) 4103/2141-9248.105656

AUTORES / AUTHORS:  - Ezeama C; Ikechebelu J; Obiechina Nj; Ezeama N

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.

RESUMEN / SUMMARY:  - BACKGROUND: Uterine leiomyomas are the commonest benign tumors in women, with a higher preponderance amongst Africans. Several etiological factors have been suggested, with subtle variations in clinical presentation being reported in different studies. This may constitute a determinant for the management measures  undertaken. AIM: To review the clinical presentation and management measures undertaken for uterine leiomyoma. SUBJECTS AND METHODS: A retrospective study was conducted at Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, from January 2002 to December 2006. A review of case records of patients with a diagnosis of uterine leiomyoma was done. The data were analyzed and presented in  tables using comparative percentages. RESULTS: Uterine leiomyoma constituted 117  of the 1094 gynecological admissions during this study period (10.7%, 117/1094).  The mean (SD) age of presentation was 35.7 (6.1) years. Most of the patients were nulliparous (76.7%, 79/103) and 51.5% (53/103) were married. The commonest mode of presentation was lower abdominal mass (66.9%, 67/103) and the least was recurrent abortion (1%, 1/103). Surgery was employed in all cases, with myomectomy being the commonest modality used in 90.3% (93/103) of cases. The common postoperative complications were prolonged pain (49.5%, 51/103) and postoperative pyrexia (34.9%, 36/103). CONCLUSION: The symptom of lower abdominal mass correlates with late presentations in our setting. This makes the application of newer therapies like laparoscopic myomectomy difficult even when they are available. Other therapies which are independent of fibroid size (like uterine artery embolization) are not readily available in our environment. This further emphasizes the importance of myomectomy as the most important treatment modality in our environment.

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[581]

TÍTULO / TITLE:  - Expression of steroid and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Mar;5(3):835-839. Epub 2012 Dec 28.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1094

AUTORES / AUTHORS:  - Yue X; Utsunomiya H; Akahira JI; Suzuki F; Ito K; Nagase S; Sasano H; Yaegashi N

INSTITUCIÓN / INSTITUTION:  - Departments of Obstetrics and Gynecology, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan ; ; Department of Obstetrics and Gynecology, Fudan University, Shanghai 042465, P.R. China.

RESUMEN / SUMMARY:  - We analyzed the expression of the steroid and xenobiotic receptor (SXR) in human  uterine sarcomas and evaluated its clinical significance. Forty-seven cases with  archival specimens were examined for SXR expression using immunohistochemistry. All cases were scored using a semi-quantitative histological scoring (HSCORE) method. Specimens with a HSCORE >40 were regarded as SXR-positive. Various clinicopathological variables, including the expression status of estrogen receptor (ER)-alpha, progesterone receptor (PR) and Ki67 (MIB-1) were examined. The mean SXR HSCOREs of carcinosarcoma (CS) and leiomyosarcoma (LMS) were 9.13 and 23.6, respectively, and SXR-positive rates were 3 out of 24 (12.5%) and 4 out of 17 (23.5%), respectively. SXR was not detected in endometrial stromal sarcoma  (ESS). In CS cases, significant differences were detected between the expression  of SXR and age and disease stages. There was no significant correlation between SXR-positive status and either disease-free survival or overall survival. Our results support an association between SXR and malignant behavior. Our results show that overexpression of SXR may represent a useful marker to identify patients with advanced-stage CS. In addition, our results showed that SXR may aid in the diagnosis of uterine sarcomas.

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[582]

TÍTULO / TITLE:  - Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNR.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(2):e58056. doi: 10.1371/journal.pone.0058056. Epub 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0058056

AUTORES / AUTHORS:  - Lang SM; Bynoe MO; Karki R; Tartell MA; Means RE

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of multicentric Castleman’s disease, primary effusion lymphoma and Kaposi’s sarcoma. In this study, we show that like the C-type lectin DC-SIGN, the closely related DC-SIGNR can also enhance KSHV infection. Following infection, they are both targeted for down modulation and our data indicate that the KSHV MARCH-family ubiquitin ligase K5 is mediating this regulation and subsequent targeting for degradation of DC-SIGN and DC-SIGNR in the context of the virus. The closely related viral K3 protein, is also able to target these lectins in exogenous expressions studies, but only weakly during viral infection. In addition to requiring a functional RING-CH domain, several protein trafficking motifs in the  C-terminal region of both K3 and K5 are important in regulation of DC-SIGN and DC-SIGNR. Further exploration of this modulation revealed that DC-SIGN is endocytosed from the cell surface in THP-1 monocytes, but degraded from an internal location with minimal endocytosis in HEK-293 cells. Pull-down data indicate that both K3 and K5 preferentially associate with immature forms of the  lectins, mediating their ubiquitylation and degradation. Together, these data emphasize the molecular complexities of K3 and K5, while expanding the repertoire of targets of these two viral proteins.

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[583]

TÍTULO / TITLE:  - Alveolar ethmoidal rhabdomyosarcoma in a young adult male.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Mar 8;2013. pii: bcr2013008737. doi: 10.1136/bcr-2013-008737.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-008737

AUTORES / AUTHORS:  - Kelly A; Moran M; Primrose W

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology, Portadown, Ulster, UK.

RESUMEN / SUMMARY:  - We report a 22-year-old man who presented with a 3 week history of left-sided headache, orbital pain and epiphora progressing to diplopia. He was being treated by his general practitioner with a beta-blocker and simple analgesia for possible diagnosis of cluster headaches. Initial examination revealed a reduction in visual acuity and poor abduction and upward gaze. Routine blood tests were normal. CT imaging was reported as a left ethmoid sinusitis with extension into a left orbit subperiosteal abscess. No pus was obtained on frontal sinus trephine and a biopsy was taken, which proved to be an alveolar-type rhabdomyosarcoma. The patient has completed a full course of chemoradiotherapy and has responded well to the treatment. His vision is back to normal and an MRI has shown complete regression of tumour.

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[584]

TÍTULO / TITLE:  - A Decade in Banking Ewing Sarcoma: A Report from the Children’s Oncology Group.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Front Oncol. 2013;3:57. doi: 10.3389/fonc.2013.00057. Epub 2013 Mar 20.

            ●● Enlace al texto completo (gratuito o de pago) 3389/fonc.2013.00057

AUTORES / AUTHORS:  - Borinstein SC; Beeler N; Block JJ; Gorlick R; Grohar P; Jedlicka P; Krailo M; Morris C; Phillips S; Siegal GP; Lawlor ER; Lessnick SL

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Hematology/Oncology, Department of Pediatrics, Vanderbilt University Nashville, TN, USA.

RESUMEN / SUMMARY:  - Outcomes for patients with metastatic and recurrent Ewing sarcoma remain poor and a better understanding of the biology of this malignancy is critical to the development of prognostic biomarkers and novel therapies. Therefore, the Children’s Oncology Group (COG) has created tissue banking protocols designed to  collect high quality, clinically annotated, tumor specimens that can be distributed to researchers to perform basic science and correlative investigation. Data from the COG Ewing sarcoma tissue banking protocols AEWS02B1  and its successor study AEWS07B1 were reviewed in this study. Six-hundred and thirty five patients were enrolled on AEWS02B1 and 396 patients have had tissue submitted to AEWS07B1. The average age of participation was 13.2 years. About 86% were less than 19 years old and only 6% were greater than 21 years of age at diagnosis. When compared to SEER data, approximately 18% of all cases and only 8% of all patients >20 years old diagnosed with Ewing sarcoma annually in the United States have had tumor banked. The majority of participants submitted formalin fixed, paraffin embedded, primary tumor and blood samples. In total, fresh frozen tissue was submitted for only 29% of cases. Only seven metastatic tumor samples have been collected. Although the COG has been successful in collecting tumor samples from patients newly diagnosed with Ewing sarcoma, fresh frozen tumor specimens from primary and metastatic disease are critically needed, especially from young adult patients, in order to conduct high quality basic science and translational research investigation with a goal of developing better treatments.

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[585]

TÍTULO / TITLE:  - Osseous metaplastic meningioma in the thoracic spine mimicking osteosarcoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Spine (Phila Pa 1976). 2013 Feb 1.

            ●● Enlace al texto completo (gratuito o de pago) 1097/BRS.0b013e31828a34e3

AUTORES / AUTHORS:  - Mannoji C; Koda M; Murakami M; Kubosawa H; Yamazaki M; Okawa A; Furuya T; Takahashi K

INSTITUCIÓN / INSTITUTION:  - Affiliations: *Department of Orthopaedic Surgery, Chiba Aoba Municipal Hospital,  Aobacho 1273-2, Chuo-ku, Chiba 260-0852, Japan daggerDepartment of Pathology, Chiba Aoba Municipal Hospital, Aobacho 1273-2, Chuo-ku, Chiba 260-0852, Japan double daggerDepartment of Orthopaedic Surgery, Chiba University Graduate School  of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan section signDepartment of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

RESUMEN / SUMMARY:  - Study Design: Case reportObjective: We describe a case of osseous metaplastic meningioma in the thoracic spine that pathologically mimicked osteosarcoma.Summary of background data: As meningioma presents in many pathological forms, it is sometimes difficult to diagnose it pathologically.Methods: The patient’s medical records, imaging results, and pathological findings were reviewed, as was the relevant literature.Results: A 20-year-old woman with a 6-month history of lumbago and right sciatica was referred to our hospital because magnetic resonance imaging (MRI) showed a tumor  compressing her spinal cord at the T11 vertebra level. Computed tomography (CT) showed calcification of the tumor, and the preoperative diagnosis was meningioma. Surgery was performed and the tumor was entirely removed. The tumor was very hard, and pathological findings suggested atypical meningioma with massive ossification. Some parts of the tumor appeared malignant, as spindle cells with a high nucleo-cytoplasmic ratio were highly concentrated, which led to the possibility of osteosarcoma. The tumor was conclusively diagnosed as osseous metaplastic meningioma based not only on the pathology, but also on CT and MRI findings and the postoperative course.Conclusions: As meningioma presents in many pathological forms, it is sometimes difficult to diagnose it pathologically. Results of imaging studies including CT and MRI, as well as patients’ postoperative course, should be considered when making a final diagnosis of meningioma.

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[586]

TÍTULO / TITLE:  - Presacral myelolipoma: a case report and review of imaging findings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Radiol Case Rep. 2012 Jun;6(6):1-9. doi: 10.3941/jrcr.v6i6.1095. Epub 2012 Jun  1.

            ●● Enlace al texto completo (gratuito o de pago) 3941/jrcr.v6i6.1095

AUTORES / AUTHORS:  - Baker KS; Lee D; Huang M; Gould ES

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA. Kevin.Baker@sbumed.org

RESUMEN / SUMMARY:  - Extra-adrenal myelolipoma is a relatively rare entity, with fewer than 50 cases reported in literature. We present a case of a 79 year-old female who presented for evaluation of hip fracture following trauma, where a lobulated presacral mass with mixed fat/soft tissue attenuation was incidentally seen on initial bone algorithm pelvic CT. Subsequent MRI showed signal characteristics of a lesion with mixed fat and soft tissue composition. The lesion demonstrated stability on  follow-up imaging. An elective surgical resection was performed which yielded a grossly fatty mass. The diagnosis of presacral myelolipoma was confirmed on microscopic examination. Following description of our case, we conduct a literature review of the imaging characteristics, diagnosis, and treatment of presacral myelolipoma.

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[587]

TÍTULO / TITLE:  - MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e53906. doi: 10.1371/journal.pone.0053906. Epub 2013 Jan 23.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0053906

AUTORES / AUTHORS:  - Zhao G; Cai C; Yang T; Qiu X; Liao B; Li W; Ji Z; Zhao J; Zhao H; Guo M; Ma Q; Xiao C; Fan Q; Ma B

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, Orthopedics Oncology Institute of Chinese PLA,  Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China.

RESUMEN / SUMMARY:  - BACKGROUND: MicroRNAs are short regulatory RNAs that negatively modulate protein  expression at a post-transcriptional and/or translational level and are deeply involved in the pathogenesis of several types of cancers. Specifically, microRNA-221 (miR-221) is overexpressed in many human cancers, wherein accumulating evidence indicates that it functions as an oncogene. However, the function of miR-221 in human osteosarcoma has not been totally elucidated. In the present study, the effects of miR-221 on osteosarcoma and the possible mechanism  by which miR-221 affected the survival, apoptosis, and cisplatin resistance of osteosarcoma were investigated. METHODOLOGY/PRINCIPAL FINDINGS: Real-time quantitative PCR analysis revealed miR-221 was significantly upregulated in osteosarcoma cell lines than in osteoblasts. Both human osteosarcoma cell lines SOSP-9607 and MG63 were transfected with miR-221 mimic or inhibitor to regulate miR-221 expression. The effects of miR-221 were then assessed by cell viability,  cell cycle analysis, apoptosis assay, and cisplatin resistance assay. In both cells, upregulation of miR-221 induced cell survival and cisplatin resistance and reduced cell apoptosis. In addition, knockdown of miR-221 inhibited cell growth and cisplatin resistance and induced cell apoptosis. Potential target genes of miR-221 were predicted using bioinformatics. Moreover, luciferase reporter assay  and western blot confirmed that PTEN was a direct target of miR-221. Furthermore, introduction of PTEN cDNA lacking 3’-UTR or PI3K inhibitor LY294002 abrogated miR-221-induced cisplatin resistance. Finally, both miR-221 and PTEN expression levels in osteosarcoma samples were examined by using real-time quantitative PCR  and immunohistochemistry. High miR-221 expression level and inverse correlation between miR-221 and PTEN levels were revealed in osteosarcoma tissues. CONCLUSIONS/SIGNIFICANCE: These results for the first time demonstrate that upregulation of miR-221 induces the malignant phenotype of human osteosarcoma whereas knockdown of miR-221 reverses this phenotype, suggesting that miR-221 could be a potential target for osteosarcoma treatment.

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[588]

TÍTULO / TITLE:  - Immunohistochemical diagnosis of gastrointestinal stromal tumors - an analysis of 80 cases from 2004 to 2010.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Adv Clin Exp Med. 2013 Jan-Feb;22(1):33-9.

AUTORES / AUTHORS:  - Kisluk J; Gryko M; Guzinska-Ustymowicz K; Kemona A; Kedra B

INSTITUCIÓN / INSTITUTION:  - Second Department of General and Gastroenterological Surgery, Medical University  of Bialystok, Bialystok, Poland.

RESUMEN / SUMMARY:  - BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common cancers of mesenchymal origin in the abdomen. An approximately 95% of GISTs show positive expression of the membrane receptor c-kit (CD117 antigen), which currently constitutes the basis for histopathological diagnosis if this type of tumor is suspected. OBJECTIVES: The aim of this study was to perform and investigate wide  parametric immunohistochemical and morphological analyses of stromal tumors diagnosed in the Podlasie province in the years 2004-2010. MATERIAL AND METHODS:  The study group consisted of 80 patients who had undergone surgical treatment for mesenchymal tumors of the gastrointestinal tract. The immunostaining technique was performed using the surgically resected material that was formalin-fixed and  embedded in paraffin blocks, then sliced into sections and stained with the monoclonal antibodies CD117, CD34, SMA, S-100 and Ki-67. RESULTS: CD117 was positively expressed in 77 cases, which confirmed the diagnosis of GIST. In 66 of the cases of CD117-positive stromal tumors, positive immunoreactivity for CD43 was observed. Nearly 49% (38 cases) of the GISTs were negative for SMA by immunohistochemistry. Most of the cases (57.5%) were reported in the stomach, while 17.5% were located in the intestines; 18.75% presented in different locations (the colon, ovary or gall bladder). CONCLUSIONS: The use of a highly sensitive IHC panel can increase the accuracy of GIST diagnoses. Detailed immunohistochemical studies are useful in successfully identifying any case of GIST, which is crucial to clinical treatment.

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[589]

TÍTULO / TITLE:  - Unusual MR Findings in Ovarian Leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Magn Reson Med Sci. 2013 Mar 25;12(1):57-61. Epub 2013 Mar 11.

AUTORES / AUTHORS:  - Kozawa E; Inoue K; Tanaka J; Meguro S; Yasuda M; Fujiwara K; Kimura F

INSTITUCIÓN / INSTITUTION:  - Department of Imaging Diagnosis, Saitama Medical University, International Medical Center.

RESUMEN / SUMMARY:  - We report a rare case of ovarian leiomyoma with extensive edema in a 55-year-old  woman. Magnetic resonance (MR) imaging revealed an ovarian mass with distinct portions of predominantly low intensity and predominantly high intensity on T2-weighted image. The portion with low signal showed weak enhancement on contrast study, and the portion with high intensity suggested extensive edema of  fibrous stroma. Furthermore, the mass showed low signal intensity similar to that of the myometrium on diffusion-weighted image and yielded high values on apparent diffusion coefficient (ADC) map image. Extensive edema of ovarian leiomyoma shows unusual MR imaging findings that require careful interpretation.

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[590]

TÍTULO / TITLE:  - Calcaneal osteosarcoma: a rare cause of heel pain in the paediatric population.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Feb 4;2013. pii: bcr2012008497. doi: 10.1136/bcr-2012-008497.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-008497

AUTORES / AUTHORS:  - Taslakian B; Issa G; Saab R; Jabbour MN; Khoury NJ

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon.

RESUMEN / SUMMARY:  - Osteosarcoma is the most common primary non-haemopoietic malignant bone tumour in children and adolescents. However, it rarely occurs in the calcaneus with only a  few case reports in the literature. We report a case of a 14-year-old boy with calcaneal osteosarcoma, who presented with heel pain followed by swelling. The pain was initially thought to be related to a benign process and treated with analgesics, delaying the diagnosis. We discuss the clinical presentation, the differential diagnosis, multi-imaging and pathological findings of a calcaneal osteosarcoma, its clinical outcome and the importance of early diagnosis to improve outcome.

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[591]

TÍTULO / TITLE:  - Occult osteoid osteoma presenting as shoulder pain: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Chiropr Med. 2012 Sep;11(3):207-14. doi: 10.1016/j.jcm.2012.06.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcm.2012.06.002

AUTORES / AUTHORS:  - Zoboski RJ

INSTITUCIÓN / INSTITUTION:  - Chiropractor, Private Practice, Summit, IL.

RESUMEN / SUMMARY:  - OBJECTIVE: The purpose of this case study is to describe the clinical course and  treatment of a patient with recalcitrant shoulder pain and osteoid osteoma. CLINICAL FEATURES: A 28-year-old man had a 2-year history of progressively worsening shoulder and midscapular pain. INTERVENTION AND OUTCOME: Before chiropractic consultation, he had been evaluated and treated by his family physician, an orthopedic surgeon, a neurologist, and a pain management specialist. The patient underwent arthroscopy with examination under anesthesia and debridement of a posterior labral tear and cervical spine epidural injections, but neither procedure relieved his symptoms. After seeking chiropractic care, presenting symptoms were reproducible during direct clinical examination; and an initial working diagnosis of secondary right glenohumeral impingement syndrome with coexisting scapulothoracic dyskinesis was made. After 2 weeks of chiropractic rehabilitation, therapy was stopped because of no change in symptoms. The patient was referred for orthopedic consultation. Another series of plain films were ordered, and follow-up magnetic resonance imaging revealed an osseous mass at the medial aspect of the proximal metadiaphyseal region of the right humerus, with a diagnosis of osteoid osteoma. The patient underwent radiofrequency thermoablation of the tumor nidus, which was unsuccessful and resulted in open surgical resection. Resolution of symptoms with minimal pain was reported 3 weeks after the surgery. Four years later, the patient’s shoulder remains asymptomatic. CONCLUSION: This case demonstrates that osteoid osteoma may present with clinical features that mimic common functional musculoskeletal conditions of the shoulder. Information from the patient history and diagnostic imaging are important for diagnosis and appropriate management.

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[592]

TÍTULO / TITLE:  - A rare malignant tumor of scalp in a 3-month-old Taiwanese infancy: case report of primitive myxoid mesenchymal tumor of infancy with molecular study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Mol Morphol. 2013 Mar 5.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00795-013-0032-1

AUTORES / AUTHORS:  - Su TC; Hwang MJ; Li CF; Wang SC; Lee CH; Chen CJ

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Pathology, Changhua Christian Hospital, 135 Nanxiao Street, Changhua, Taiwan.

RESUMEN / SUMMARY:  - Primitive myxoid mesenchymal tumor of infancy is an extremely rare and recently recognized soft tissue tumor entity with a tendency for multiple recurrences. Only ten cases have been described in the literature and most cases are reported  in Western countries. This tumor ranges in size from 2 to 15 cm and is characterized microscopically by a diffuse growth of primitive cells in a myxoid  background with focal fascicles or a herringbone pattern. In this study, we describe a primitive myxoid mesenchymal tumor of infancy on the scalp of a 3-month-old Taiwanese boy. The histology showed typical morphology and the tumor  cells showed vimentin and CD99 immunoreactivities. The translocation t(12,15)(p13;q25) was not found by fluorescence in situ hybridization. After complete surgical excision, no recurrence was noted during an 18-month follow-up.

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[593]

TÍTULO / TITLE:  - Analysis of Epithelial Growth Factor-Receptor (EGFR) Phosphorylation in Uterine Smooth Muscle Tumors: Correlation to Mucin-1 and Galectin-3 Expression.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Mol Sci. 2013 Feb 28;14(3):4783-92. doi: 10.3390/ijms14034783.

            ●● Enlace al texto completo (gratuito o de pago) 3390/ijms14034783

AUTORES / AUTHORS:  - Weissenbacher T; Vrekoussis T; Roeder D; Makrigiannakis A; Mayr D; Ditsch N; Friese K; Jeschke U; Dian D

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology, Innenstadt Campus, Ludwig-Maximilians-University, Munich 80337, Germany. udo.jeschke@med.uni-muenchen.de.

RESUMEN / SUMMARY:  - Uterine fibroids are the commonest uterine benign tumors. A potential mechanism of malignant transformation from leiomyomas to leiomyosarcomas has been described. Tyrosine phosphorylation is a key mechanism that controls biological functions, such as proliferation and cell differentiation. The aim of the current study was to evaluate the phosphorylation of epithelial growth factor-receptor (EGFR) in normal myometrium, uterine myomas and uterine leiomyosarcomas. Formalin-fixed paraffin-embedded tissue samples from normal myometrium, leiomyomas and leiomyosarcomas were studied. Samples were immunohistochemically (IHC) assessed using the anti-EGFR phosphorylation of Y845 (pEGFR-Y845) and anti-pEGFR-Y1173 phosphorylation-specific antibodies. IHC staining was evaluated  using a semiquantitative score. The expression of pEGFR-Y845 was significantly upregulated in leiomyosarcomas (p < 0.001) compared to leiomyomas and normal myometrium. In contrast, pEGFR-Y1173 did not differ significantly between the three groups of the study. Correlation analysis revealed an overall positive correlation between pEGFR Y845 and mucin 1 (MUC1). Further subgroup analysis within the tumoral group (myomas and leiomyosarcomas) revealed an additional negative correlation between pEGFR Y845 and galectin-3 (gal-3) staining. On the contrary no significant correlation was noted within the non-tumoral group. An upregulated EGFR phosphorylation of Y845 in leiomyosarcomas compared to leiomyomas implicates EGFR activation at this special receptor site. Due to these pEGFR-Y845 variations, it can be postulated that MUC1 interacts with it, whereas  gal-3 seems to be cleaved from Y845 phosphorylated EGFR. Further research on this field could focus on differences in EGFR pathways as a potentially advantageous diagnostic tool for investigation of benign and malignant signal transduction processes.

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[594]

TÍTULO / TITLE:  - Fibromatous lesions of antler velvet and haired skin in reindeer (Rangifer tarandus).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Vet Rec. 2013 Mar 27.

            ●● Enlace al texto completo (gratuito o de pago) 1136/vr.101499

AUTORES / AUTHORS:  - Foster AP; Barlow AM; Nasir L; Wilson CD; Everest DJ; Erdelyi K; Finnegan CJ; Schock A

INSTITUCIÓN / INSTITUTION:  - Animal Health and Veterinary Laboratories Agency (AHVLA)-Shrewsbury, Kendal Road, Harlescott, Shrewsbury, Shropshire SY1 4HD, UK.

 

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[595]

TÍTULO / TITLE:  - Anterior interhemispheric calcified lipoma together with subcutaneous lipoma and  agenesis of corpus callosum: a rare manifestation of midline craniofacial dysraphism.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Jpn J Radiol. 2013 Mar 17.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11604-013-0200-1

AUTORES / AUTHORS:  - Karakas O; Karakas E; Boyaci FN; Celik B; Cullu N

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Faculty of Medicine, Harran University, 63300, Sanliurfa, Turkey, dromerkarakas@hotmail.com.

RESUMEN / SUMMARY:  - Frontonasal dysplasia (FND) or craniofacial dysraphism includes a variety of craniofacial defects. FNDs are rarely associated with intracranial lipoma. The majority of intracranial lipomas are incidentally identified on radiological examinations. They are commonly accompanied by other congenital intracranial malformations. Moreover, they are rarely associated with subcutaneous lipoma. We  present a rare case of midline craniofacial dysraphism with interhemispheric calcified lipoma together with subcutaneous lipoma and agenesis of the corpus callosum.

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[596]

TÍTULO / TITLE:  - Expression of stem cell factor in gastrointestinal stromal tumors: Implications for proliferation and imatinib resistance.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Feb;5(2):552-558. Epub 2012 Nov 9.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1019

AUTORES / AUTHORS:  - Hou XW; Bai CG; Liu XH; Qiu C; Huang L; Xu JJ; Ma DL

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433; ; Department of Oncology, 401 Hospital of PLA, Qingdao, Shandong 266071;

RESUMEN / SUMMARY:  - KIT autophosphorylation caused by mutation of KIT is considered to be a critical  mechanism for the oncogenesis of gastrointestinal stromal tumors (GISTs). However, little is known regarding whether stem cell factor (SCF), the KIT ligand, is able to induce the proliferation of GIST cells by activating the wild-type KIT receptor in GISTs. Imatinib, a tyrosine kinase inhibitor, has been  demonstrated to be effective as treatment for the majority of GISTs. However, primary resistance to imatinib in GISTs with wild-type KIT and acquired resistance in GISTs with mutant KIT are becoming increasingly significant problems. The aims of this study were to detect the expression and function of SCF in 68 GIST samples, and to explore the relationship between SCF activity and  imatinib resistance using immunohistochemical staining and western blot analysis. Results showed abundant expression of SCF in GISTs and demonstrated that SCF is capable of enhancing GIST cell proliferation. Similar to its ineffectiveness in wild-type GISTs, imatinib also failed to inhibit SCF-induced KIT activation in GISTs with mutant KIT. We also found increased SCF expression in GIST cells treated with imatinib. Overall, our results indicated that SCF-induced KIT activation is a novel essential pathway for the proliferation of GISTs. Imatinib  was not able to inhibit the activity of SCF, while it promoted the expression of  SCF, which may have contributed to acquired imatinib resistance.

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[597]

TÍTULO / TITLE:  - Surgical resection with adjuvant brachytherapy in soft tissue sarcoma of the extremity - a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Contemp Brachytherapy. 2012 Dec;4(4):227-31. doi: 10.5114/jcb.2012.32557. Epub  2012 Dec 28.

            ●● Enlace al texto completo (gratuito o de pago) 5114/jcb.2012.32557

AUTORES / AUTHORS:  - Guzik G; Lyczek J; Kowalik L

INSTITUCIÓN / INSTITUTION:  - Oncologic Orthopaedics Department.

RESUMEN / SUMMARY:  - PURPOSE: Surgery is the major therapeutic method in soft tissue sarcomas of the extremity (E-STS). Treatment of large high-grade tumours, which resection cannot  be performed with a wide safe margin, should include complementary radiation and/or chemo-therapy. Hopefully, the use of adjuvant brachytherapy will improve the prognosis of E-STS. CASE DESCRIPTION: After a long process of diagnosing a tumour in the medial compartment of the thigh, a 65-year-old woman with diagnosed synovial sarcoma underwent a surgery. Compartment resection was performed and the tumour was removed with a 10 mm safety margin of healthy tissue. Adjuvant brachytherapy was delivered with (192)Ir (MicroSelectron, Nucletron Electa Group, Stockholm, Sweden(®)) with 10 Ci of nominal activity to a dose of 55 Gy in 16 days because of large tumour size (99 x 78 x 73 mm) and its proximity to the neurovascular bundle. No complications were reported. The patient was discharged  from the hospital on the 28(th) day after the surgery. The wound healed without any complications and the outpatient follow-up is being continued. DISCUSSION: Adjuvant brachytherapy is rarely used after surgical treatment due to its limited accessibility in hospitals with surgical and orthopaedic departments. There are numerous publications proving positive influence of brachytherapy on local control and decreased number of recurrences. The recurrence-free survival time also increased significantly, however no direct impact on the number of distant metastases was found. Treatment is well tolerated and short. The complication rate varies between centres from 5 to 30%. The most common adverse effects include: peripheral neuropathy, skin necrosis and osteonecrosis of the long bones. CONCLUSIONS: Treatment of large soft tissue sarcomas of the extremity (E-STS) should include combination of surgical intervention and external beam radiotherapy or brachytherapy. Adjuvant brachytherapy improves local control rate up to 78%, is well tolerated and rarely causes complications. We couldn’t determine which type of adjuvant radiation therapy is more effective.

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[598]

TÍTULO / TITLE:  - Endometrial stromal tumors: immunohistochemical and molecular analysis of potential targets of tyrosine kinase inhibitors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Sarcoma Res. 2013 Mar 7;3(1):3. doi: 10.1186/2045-3329-3-3.

            ●● Enlace al texto completo (gratuito o de pago) 1186/2045-3329-3-3

AUTORES / AUTHORS:  - Sardinha R; Hernandez T; Fraile S; Tresserra F; Vidal A; Gomez MC; Astudillo A; Hernandez N; Saenz de Santamaria J; Ordi J; Goncalves L; Ramos R; Balana C; de Alava E

INSTITUCIÓN / INSTITUTION:  - Centro de Investigacion del Cancer-IBMCC USAL-CSIC, Salamanca, España. edealava@usal.es.

RESUMEN / SUMMARY:  - BACKGROUND: The systemic treatment of malignant endometrial stromal tumors (EST)  is not well established. A few reports describe objective responses to imatinib,  which suggest a novel therapeutic strategy for these tumors. Due to these facts,  we aimed to perform a retrospective analysis of possible molecular targets of tyrosine kinase inhibitors (TKI) in EST: KIT, PDGFRA and EGFR. METHODS: 52 endometrial stromal sarcomas and 13 undifferentiated endometrial sarcomas were examined and reviewed. Mutational analysis were performed for exons 9, 11, 13, and 17 of the KIT gene, exons 12 and 18 of the PDGFRA gene and exons 18, 19, 20 and 21 of the EGFR gene. The incidence and distribution of the KIT, PDGFRA, and EGFR expression were examined by immunohistochemistry, and EGFR amplification was assessed by fluorescence in situ hybridization. RESULTS: No mutations in KIT, PDGFRA and EGFR genes were detected. Overexpression of KIT, PDGFRA, EGFR, was detected in 2 (3%), 23 (35.4%), 7 (10.8%) cases respectively, whereas amplification of EGFR gene was not found. CONCLUSIONS: Absence of significant expression, amplification and activating mutations on these tyrosine kinase receptors suggest that it is unlikely that EST can benefit from therapies such as TKI on the systemic setting.

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[599]

TÍTULO / TITLE:  - A rare cervical dystonia mimic in adults: congenital muscular torticollis (fibromatosis colli).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Front Neurol. 2013;4:6. doi: 10.3389/fneur.2013.00006. Epub 2013 Feb 12.

            ●● Enlace al texto completo (gratuito o de pago) 3389/fneur.2013.00006

AUTORES / AUTHORS:  - Gonzalez-Usigli H; Espay AJ

INSTITUCIÓN / INSTITUTION:  - Department of Neurology, Gardner Family Center for Parkinson’s Disease and Movement Disorders, University of Cincinnati School of Medicine Cincinnati, OH, USA.

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[600]

TÍTULO / TITLE:  - Angiolipoma: rare cause of adult ileoileal intussusception.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Mar 26;2013. pii: bcr2013008921. doi: 10.1136/bcr-2013-008921.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-008921

AUTORES / AUTHORS:  - Esnakula AK; Sinha A; Fidelia-Lambert M; Tammana VS

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Howard University Hospital, Washington, DC, USA.

RESUMEN / SUMMARY:  - Intussusception in adults is rare and more common in the paediatric population. Clinically, most adult patients have chronic non-specific symptoms due to partial obstruction. In contrast, most paediatric patients present with the classic triad of abdominal pain, vomiting and blood in stool. Adult intussusception is commonly associated with an organic aetiology, most likely a benign or malignant neoplasm  as a lead point of intussusception. We describe a case of a 29-year-old woman with subacute presentation due to ileoileal intussusception secondary to a polypoid submucosal angiolipoma. Angiolipoma is a benign lesion composed of mature adipose tissue and thin-walled capillaries. The presence of thin-walled vessels differentiates it from a lipoma. Angiolipomas of the small intestine are  extremely rare with very few reported cases. This case not only demonstrates an unusual benign lesion as a cause of intussusception, but also illustrates an atypical clinical presentation in adults with intussusception.

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[601]

TÍTULO / TITLE:  - Colo-colic intussusception secondary to lipomatous polyp in an adult.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Mar 5;2013. pii: bcr2012008037. doi: 10.1136/bcr-2012-008037.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-008037

AUTORES / AUTHORS:  - Rutherford CL; Alkhaffaf B; Massa E; Turner P

INSTITUCIÓN / INSTITUTION:  - Lancashire Teaching Hospitals NHS Trust, Preston, UK.

RESUMEN / SUMMARY:  - A woman in her early 50s presented with a 2-week history of gradually worsening colicky abdominal pain with associated vomiting, loose stools and reduced appetite. There was no malaena or perrectal bleeding. On examination, there was tenderness in the epigastric region with an associated palpable fullness. Subsequent imaging revealed a substantial colo-colic intussusception with the lead point being a lipoma of the ascending colon. Subsequent colonic resection was undertaken with histology confirming a lipomatous polyp.

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[602]

TÍTULO / TITLE:  - Hemangiosarcoma in a geriatric Labrador retriever.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Can Vet J. 2012 Aug;53(8):889-92.

AUTORES / AUTHORS:  - Sharma D

INSTITUCIÓN / INSTITUTION:  - Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.

RESUMEN / SUMMARY:  - A geriatric Labrador retriever dog was presented for acute collapse. The dog was  conscious but lethargic, tachypneic, tachycardic with weak femoral pulses, occasional pulse deficits, and pale mucous membranes. Radiography, ultrasonography, quick assessment tests, and a complete blood (cell) count (CBC)/biochemistry panel indicated internal hemorrhage and potential problems with hemostasis. The dog was euthanized. A necropsy, histopathology, and immunohistochemistry for CD31 and Factor VIII-related antigen cell markers supported a diagnosis of splenic hemangiosarcoma.

 

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[603]

TÍTULO / TITLE:  - Management of a female with recurrence of fibromatosis of the chest wall adjacent to the breast: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cardiothorac Surg. 2013 Mar 8;8:41. doi: 10.1186/1749-8090-8-41.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1749-8090-8-41

AUTORES / AUTHORS:  - Shen C; Zhou Y; Che G

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, West-China Hospital, Sichuan University, Chengdu, 610041, China. cheguowei@yahoo.com.cn.

RESUMEN / SUMMARY:  - Extra-abdominal desmoid tumor is a rare soft tissue tumor that is histologically  benign, but may behave aggressively. This case report specifically describes the  clinical, radiographic, and pathologic features of 27 year-old female who experienced a post-surgical recurrence of fibromatosis of the chest wall over a two-year period of time secondary to previous inadequate excision. The fibromatosis was found to be involving the lower-inner quadrant of her right breast and causing worsening pain. A surgical management strategy was successfully undertaken.

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[604]

TÍTULO / TITLE:  - Variable Ki67 proliferative index in 65 cases of nodular fasciitis, compared with fibrosarcoma and fibromatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2013 Mar 26;8(1):50.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-8-50

AUTORES / AUTHORS:  - Lin XY; Wang L; Zhang Y; Dai SD; Wang EH

RESUMEN / SUMMARY:  - Nodular fasciitis is the most common pseudosarcomatous lesion of soft tissue. Ki67 was considered as a useful marker for distinguishing some benign and malignant lesions. To study the usefulness of Ki67 in diagnosis of nodular fasciitis, the expression of Ki67 was examined by using immunostaining in 65 nodular fasciitis specimens, 15 desmoid fibromatosis specimens and 20 fibrosarcoma specimens. The results showed that there was a variable Ki67 index in all 65 cases of nodular fasciitis, and the mean labeling index was 23.71+/-15.01%. In majority (70.77%) of all cases,the index was ranged from 10% to 50%, in 6.15% (4/65) of cases the higher Ki67 index (over 50%) could be seen.  The Ki67 proliferative index was closely related to duration of lesion, but not to age distribution, lesion size, sites of lesions and gender. Moreover, the mean proliferative index in desmoid fibromatosis and fibrosarcoma was 3.20+/-1.26% and 26.15+/-3.30% respectively. The mean Ki67 index of nodular fasciitis was not significantly lower than fibrosarcoma, but higher than desmoid fibromatosis. The  variable and high Ki67 index in nodular fasciitis may pose a diagnostic challenge. We should not misdiagnose nodular fasciitis as a sarcoma because of its high Ki67 index. The recurrence of nodular fasciitis is rare; and the utility of Ki67 immunostaining may be not suitable for recurrence assessment in nodular fasciitis. Virtual slides The virtual slide(s) for this article can be found here: diagnosticpathology.diagnomx.eu/vs/4782335818876666.

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[605]

TÍTULO / TITLE:  - Is this a mediastinal tumor? A case of Morgagni hernia complicated with intestinal incarceration mistaken for the mediastinal lipoma previously.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Case Rep. 2013;4(3):302-4. doi: 10.1016/j.ijscr.2012.12.010. Epub 2013 Jan 16.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2012.12.010

AUTORES / AUTHORS:  - Komatsu T; Takahashi Y

INSTITUCIÓN / INSTITUTION:  - Department of General Thoracic Surgery, Kobe City Medical Center General Hospital, Japan. Electronic address: tk.thoracic@gmail.com.

RESUMEN / SUMMARY:  - INTRODUCTION: Morgagni’s hernia is a congenital herniation of abdominal viscera into the thoracic cavity through a retrosternal diaphragmatic defect. PRESENTATION OF CASE: We present a case of incarcerated Morgagni hernia in a 69-year-old woman. Three years previously, she had undertaken a video-assisted thoracoscopic resection (VATS) of a mediastinal mass, which had been mistaken for a lipoma. Following the primary repair of the hernia at emergency laparotomy, the patient was discharged home uneventfully. DISCUSSION: Irrespective of the radiologically characteristic findings of our case, the possibility of Morgagni hernia had not been entertained at the first operation. Thorough exploration around the diaphragm at the first VATS operation could have revealed the Morgagni hernia, ultimately avoiding the hernia-related complication such as an incarceration. CONCLUSION: Morgagni hernia as a differential diagnosis in case of anterior mediastinal mass should not be missed.

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[606]

TÍTULO / TITLE:  - Endoscopic endonasal resection of skull base chordoma: case series and review of  literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Inj Violence Res. 2012 Nov;4(3 Suppl 1). pii: Paper No. 54.

AUTORES / AUTHORS:  - Samadian M; Samimi SH; Akbari Dilmaghani N; Moghadasi H; Ebrahimzadeh K; Ghorbani J; Khazanehdari S

INSTITUCIÓN / INSTITUTION:  - Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

RESUMEN / SUMMARY:  - BACKGROUND: Skull base chordoma is a rare tumor with slow and progressive growth. Significance of this tumor is it’s difficult to access location in skull base. This is the reason for various proposed techniques for resection of the tumor. Endoscopic endonasal technique is a minimally invasive approach that gives surgeons opportunity of total resection of tumor and low morbidity. Total resection of the tumor is the main determining factor of prognosis. METHODS: In this article we retrospectively studied 18 patients with pathological diagnosis of skull base chordoma treated in Amiralam hospital, Loghman-Hakim hospital and Day general hospital, Tehran, Iran, between 2005 and 2012. All patients underwent endoscopic endonasal surgery. Thirteen patients were primary cases but 3 and 2 cases were referred respectively after radiation failure and recurrence after craniotomy. Mean follow-up time was 23 months. Difficulty in swallowing and speech, diplopia and nasal obstruction was common presenting symptoms. RESULTS: Gross tumor resection was feasible in 13 cases. Subtotal resection was done in 5  cases. During follow-up, 1 case died from disease and tumor recurred in other 8 cases. Nine patients are disease free. Eight recurrences and 1 mortality were in  cases that underwent subtotal resection or referred to us after radiation failure. The major operative complication was a case of pneumocephalus. CONCLUSIONS: Endoscopic endonasal resection of skull base chordoma is a low morbidity approach, advisable in most cases. We think that total resection is the best surgical strategy. We recommend postoperative radiation in all patients. KEYWORDS: Endoscopic, Endonasal, Skull base, Chordoma.

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[607]

TÍTULO / TITLE:  - Case images: volume measurement of a cardiac myxomatous lesion with three-dimensional echocardiography.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Turk Kardiyol Dern Ars. 2012 Oct;40(7):651. doi: 10.5543/tkda.2012.56588.

AUTORES / AUTHORS:  - Demirkol S; Arslan Z; Balta S; Kucuk U

INSTITUCIÓN / INSTITUTION:  - Department of Cardiology, GATA Medical Faculty, Ankara, Turkey.

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[608]

TÍTULO / TITLE:  - Giant omental lipoblastoma and CD56 expression.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Afr J Paediatr Surg. 2013 Jan-Apr;10(1):32-4. doi: 10.4103/0189-6725.109389.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0189-6725.109389

AUTORES / AUTHORS:  - Miyano G; Hayashi T; Arakawa A; Goto S; Lane GJ; Okazaki T; Yamataka A

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan.

RESUMEN / SUMMARY:  - We report a case of giant omental lipoblastoma in a 13-month-old boy, which was treated successfully by total excision. Tumor cells were positive for S100, CD34  and CD56. This is the first report of lipoblastoma expressing CD56, a fact that could be used to differentiate lipoblastoma from liposarcoma.

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[609]

TÍTULO / TITLE:  - Evaluation of the expression and role of IGF pathway biomarkers in human sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Immunopathol Pharmacol. 2013 Jan-Mar;26(1):169-77.

AUTORES / AUTHORS:  - Lin F; Shen Z; Xu X; Hu BB; Meerani S; Tang LN; Zheng SE; Sun YJ; Min DL; Yao Y

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, Shanghai Jiaotong University Affiliated Sixth Peoples Hospital, Shanghai, China.

RESUMEN / SUMMARY:  - Recent studies have shown that insulin-like growth factor (IGF) signaling components have been involved in the pathogenesis and progression of different types of sarcomas. There has been some evidence to indicate the differential expression of IGF2 and insulin-like growth factor 1 receptor (IGF1R) in human sarcomas. The present study utilized immunohistochemistry (IHC) and in situ hybridization (ISH) to determine the expression of IGF2 and IGF1R in eighty-two cases of human sarcoma specimens and eight cases of non-tumor tissue (NTT). IGF2/IGF1R signaling was blocked by recombinant adenovirus-mediated IGF1R small hairpin RNA (shIGF1R), which was used to transfect into human osteosarcoma (OS) MG-63 cells. The expression of IGF2, IGF1R, matrix metallopeptidase-2 (MMP-2) and MMP-9 was detected by Real-time PCR. Cell migration was evaluated by wound healing assay. As a consequence, the expression of IGF1R and IGF2 was found in human OS with higher strong reactivity rate compared with the NTT (85.0 percent vs 50.0 percent, P=0.022; 95.0 percent vs 100.0 percent, P=0.042), elevating with the ascending order of tumor malignancy. Also, IGF1R had differential expression  in different types of sarcomas (P=0.002), while IGF2 had no significant difference (P=0.105). Targeted blockade of IGF2/IGF1R signaling decreased the expression of IGF2, IGF1R, and MMP-2/-9, and diminished the migration capabilities of MG-63 cells. In conclusion, IGF1R is differentially-expressed in  different types of human sarcomas, and targeted blockade of IGF1R pathway may inhibit human OS migration through down-regulation of MMP-2/-9 expression. IGF1R  pathway may represent a significant therapeutic modality for the treatment of sarcomas.

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[610]

TÍTULO / TITLE:  - Expression of Phosphoinositide-specific phospholipase C enzymes in human osteosarcoma cell lines.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cell Commun Signal. 2013 Feb 22.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12079-013-0194-6

AUTORES / AUTHORS:  - Lo Vasco VR; Leopizzi M; Chiappetta C; Puggioni C; Di Cristofano C; Della Rocca C

INSTITUCIÓN / INSTITUTION:  - Department of Sensitive Organs, Policlinic Umberto I, Faculty of Medicine and Odontoiatry, Sapienza University of Rome, viale del Policlinico 155, Rome, 00185, Italy, ritalovasco@hotmail.it.

RESUMEN / SUMMARY:  - The definition of the number and nature of signal transduction pathways networking in the pathogenesis of osteosarcoma raised great interest. Intracellular calcium ions are important second messengers implicated in the control of cell death. The calcium concentration is regulated by signal transduction pathways, including the Phosphoinositides (PI) signaling. Phosphatydil inositol (4,5) bisphosphate (PIP2) is critical for many cellular activities. The levels of PIP2 are regulated by means of Phosphoinositide-specific Phospholipase C (PI-PLC) family of enzymes. We delineated the panel of expression of PI-PLC enzymes in four human osteosarcoma cell lines. In MG-63 cell line, PI-PLC beta1, beta2, beta3, beta4, gamma1, gamma2, delta1, delta3 and epsilon resulted expressed. In 143B cell line, PI-PLC  beta1, beta2, beta3, beta4, gamma1, gamma2, delta1, delta3 and epsilon were expressed. In SaOS-2 cell line, PI-PLC beta1, beta3, beta4, gamma1, gamma2, delta1, delta3, epsilon and eta1. In Hs888 cell line, PI-PLC beta1, beta3, beta4, gamma1, delta1, delta3, delta4, epsilon and eta1 the administration of U-73122 to cultures briefly modifies the levels of PI-PLC transcripts. The obtained complete expression panel of PI-PLC isoforms will be a useful tool for further functional  studies about the role of the PI signal transduction pathway in osteosarcoma.

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[611]

TÍTULO / TITLE:  - Genitourinary rhabdomyosarcoma: Unusual diagnosis presenting within hours of delivery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Urol. 2013 Mar 16. pii: S1477-5131(13)00050-8. doi: 10.1016/j.jpurol.2013.02.010.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpurol.2013.02.010

AUTORES / AUTHORS:  - Marietti S; Saenz N; Willert J; Holmes N

INSTITUCIÓN / INSTITUTION:  - University of California, San Diego and Rady Children’s Hospital, 3020 Children’s Way, San Diego, CA 92123, USA. Electronic address: smarietti@rchsd.org.

RESUMEN / SUMMARY:  - Genitourinary rhabdomyosarcoma of the newborn is extremely rare. We present a case report of a newborn delivered with a palpable abdominal mass revealing rhabdomyosarcoma on biopsy. Prenatal care was normal. The child was treated with  multimodal therapy including extensive chemotherapy, surgical excision, and radiation therapy. Surgical excision included cystoprostatectomy, ureterostomy, abdominoperineal resection and colostomy placement. He continued to progress and  eventually succumbed to his disease.

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[612]

TÍTULO / TITLE:  - Odontogenic fibromyxoma of maxilla: a rare case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Dent. 2013;2013:345479. doi: 10.1155/2013/345479. Epub 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/345479

AUTORES / AUTHORS:  - Reddy GS; Kumar BS; Muppa R; Regonda SK; Tvs HK

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, Panineeya Institute of Dental Sciences, Road No. 5, Kamala Nagar, Dilsukhnagar, Hyderabad, Andhra Pradesh 500060, India.

RESUMEN / SUMMARY:  - Fibromyxoma is a rare odontogenic tumour which is benign, but locally aggressive. The etiology of these tumours is unknown, but because of its limitation to the teeth bearing areas and occasional presence of odontogenic epithelial fragments within the tumour which suggest that it is of odontogenic origin. It is a slow growing painless tumour that frequently occurs in second and third decades of life. Females are more commonly affected than males. The tumour can cause gradual expansion of the cortical plates and cause loosening and displacement of teeth, although root resorption may be rare. The surgical treatment of these tumours consists of complete enucleation or radical excision. The aim of this paper is to present the rarity of a fibromyxoma of the maxilla.

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[613]

TÍTULO / TITLE:  - Primary epiphyseal Ewing sarcoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Orthop Traumatol Turc. 2012;46(6):460-3.

AUTORES / AUTHORS:  - Bulbul M; Ozger H; Bilgic B; Eralp L

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics and Traumatology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey. muratbulbul@yahoo.com

RESUMEN / SUMMARY:  - Ewing sarcoma is a frequently seen malignant bone tumor of the childhood. The tumor involves the diaphyseal and metaphyseal bone and cases located in the epiphysis are unusual. We present a case of Ewing sarcoma limited to the epiphysis in an immature skeleton. We would like to emphasize the importance of the biopsy without contaminating the joint space which will reduce the morbidity  during the curative surgery.

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[614]

TÍTULO / TITLE:  - Myelolipoma of the posterior mediastinum: report of a case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gen Thorac Cardiovasc Surg. 2013 Mar 11.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11748-013-0230-8

AUTORES / AUTHORS:  - Ema T; Kawano R

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, Itabashi Central Medical Center, 2-12-7 Azusawa,  Itabashi-ku, Tokyo, 174-0051, Japan, toshinariema09@yahoo.co.jp.

RESUMEN / SUMMARY:  - Myelolipoma is an uncommon tumor composed of adipose tissue and normal hematopoietic elements, and is most often found in the adrenal glands. We report  a patient with a posterior mediastinal myelolipoma. The 68-year-old male patient  showed a right lower mediastinal shadow in a chest X-ray. A computed tomographic  scan demonstrated a right posterior mediastinal mass. Magnetic resonance imaging  provided additional useful information. The patient underwent a successful resection under video-assisted thoracoscopic surgery.

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[615]

TÍTULO / TITLE:  - Dedifferentiated chondrosarcoma of the cervical spine: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Feb 2;11:32. doi: 10.1186/1477-7819-11-32.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-32

AUTORES / AUTHORS:  - Matsumoto Y; Takahashi Y; Harimaya K; Nakagawa T; Kawaguchi K; Okada S; Hayashida M; Doi T; Sakamoto A; Matsunobu T; Oda Y; Iwamoto Y

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ymatsu@ortho.med.kyushu-u.ac.jp.

RESUMEN / SUMMARY:  - Dedifferentiated chondrosarcoma (DDCS) is a rare and aggressive bone tumor with poor prognosis. Primary DDCS of the mobile spine is extremely rare, particularly  in the cervical spine. We herein describe a first case of cervical DDCS in an 81-year-old male presenting with a slowly growing mass. Radiographs showed an expansion of the cortical contour of the C2 lamina and a soft tissue mass with punctate calcification. Magnetic resonance imaging demonstrated a lobulated lesion expanding over the entire lamina and pedicles of C2 with the tumor protuberant to the adjacent soft tissue. A complete tumor resection was performed. Histologically, the majority of the tumor was a low-grade chondrosarcoma component. However, atypical spindle cells that had proliferated in a fascicular pattern with a collagenous stroma, mimicking fibrosarcoma, were focally observed without a transitional zone, and these features confirmed that the tumor was DDCS.

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[616]

TÍTULO / TITLE:  - Ciliary body leiomyoma: case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Clin Croat. 2012 Dec;51 Suppl 1:83-6.

AUTORES / AUTHORS:  - Abraham-Marin M; Villar-Kuri J; Stangogiannis-Druya E; Velasco-Barona C; Rodriguez-Reyes A; Moragrega-Adame E

INSTITUCIÓN / INSTITUTION:  - Department of Ultrasonography, Hospital Luis Sanchez Bulnes Asociacion Para Evitar la Ceguera en Mexico IAP, DF Mexico. maura.abraham@gmail.com

RESUMEN / SUMMARY:  - A 41-year-old female complained of impaired vision on her left eye in the past year. Her visual acuity was 20/20 on the right eye and 20/50 on the left eye. In  her left eye, there was an ill-defined, irregularly pigmented, orange lesion at 7 o’clock meridian behind the iris. Standardized ultrasound A-scan and B-scan revealed a large, rounded ciliary body lesion with inner homogeneous structure, medium internal reflectivity and positive vascularity. Under the ultrasonographic diagnosis of leiomyoma, iridocyclectomy was performed. Histopathologic examination revealed ciliary body leiomyoma.

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[617]

TÍTULO / TITLE:  - A Rare Case of Primary osteosarcoma of urinary bladder.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Imaging Sci. 2012;2:82. doi: 10.4103/2156-7514.105145. Epub 2012 Dec 27.

            ●● Enlace al texto completo (gratuito o de pago) 4103/2156-7514.105145

AUTORES / AUTHORS:  - Siddappa JK; Singla S; Jain A; Kumar A

INSTITUCIÓN / INSTITUTION:  - Department of Radiodiagnosis, M. S. Ramaiah Medical College and Teaching Hospital MSRIT Post, New BEL Road, Bangalore, India.

RESUMEN / SUMMARY:  - Extraskeletal osteosarcoma is a malignant mesenchymal soft tissue tumor without attachment to the bone, and is able to produce osteoid or cartilaginous matrix. This entity accounts for 1% of all soft tissue sarcomas. Thus far, less than 35 cases of bladder osteosarcomas have been reported in the literature. These tumors are associated with very poor prognosis. We report a case of primary osteosarcoma of the urinary bladder presenting with intermittent hematuria, dysuria, and right flank pain. Contrast-enhanced computed tomography scan of the abdomen, pelvis, and chest revealed a bladder mass and pulmonary metastases with specks of calcification.

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[618]

TÍTULO / TITLE:  - Malignant solitary fibrous tumor of the kidney: report of the first case managed  with interferon.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol Med. 2013;2013:564980. doi: 10.1155/2013/564980. Epub 2013 Jan 15.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/564980

AUTORES / AUTHORS:  - Cuello J; Bruges R

INSTITUCIÓN / INSTITUTION:  - Clinical Oncology Group, Cancerology National Institute, E.S.E., Bogota, Colombia ; El Bosque University, Bogota, Colombia.

RESUMEN / SUMMARY:  - Solitary fibrous tumors of the kidney are extremely rare tumors with unpredictable behavior. We describe a case of a patient with a solitary fibrous tumor of kidney with malignant findings with distant metastasis and nephrectomy managed with subcutaneous interferon achieving 23 months of progression-free survival. To date there is no prospective evaluation of any specific modality of  treatment, but the surgical management and long-term followup are the only ones so far recommended strategies in the management of these patients. Studies are awaited with more patients to evaluate the different strategies of systemic therapy reported so far to allow adding survival benefit.

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[619]

TÍTULO / TITLE:  - Sclerosing rhabdomyosarcoma presenting in the masseter muscle: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2013 Feb 4;8:18. doi: 10.1186/1746-1596-8-18.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-8-18

AUTORES / AUTHORS:  - Lin XY; Wang Y; Yu JH; Liu Y; Wang L; Li QC; Wang EH

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang 110001, China.

RESUMEN / SUMMARY:  - Sclerosing rhabdomyosarcoma (SRMS) is exceedingly rare, and may cause a great diagnostic confusion. Histologically, it is characterized by abundant extracellular hyalinized matrix mimicking primitive chondroid or osteoid tissue.  So, it may be easily misdiagnosed as chondrosarcoma, osteosarcoma, angiosarcoma and so on. Herein, we report a case of SRMS occurring in the masseter muscle in a 40-year-old male. The tumor showed a diverse histological pattern. The tumor cells were arranged into nests, cords, pseudovascular, adenoid, microalveoli and  even single-file arrays. Immunostaining showed that the tumor was positive for the Vimentin, Desmin and MyoD1, and was negative for CK, P63, NSE, CD45, CD30, S-100, CD99, Myoglobin, CD68, CD34, CD31, and alpha-SMA. Based on the morphological finding and immunostaining, it was diagnosed as a SRMS. In addition, focally, our case also displayed a cribriform pattern resembling adenoid cystic carcinoma. This may represent a new histological feature which can broaden the histological spectrum of this tumor and also may lead to diagnostic confusion. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: diagnosticpathology.diagnomx.eu/vs/1615846455818924.

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[620]

TÍTULO / TITLE:  - Paratesticular pleomorphic rhabdomyosarcoma: a report of two cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Urol. 2013;2013:807979. doi: 10.1155/2013/807979. Epub 2013 Feb 12.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/807979

AUTORES / AUTHORS:  - Boulma R; Gargouri MM; Sallemi A; Chlif M; Fitouri Z; Kallel Y; Nouira Y

INSTITUCIÓN / INSTITUTION:  - Department of Urology, La Rabta University Hospital, 1007 Tunis, Tunisia.

RESUMEN / SUMMARY:  - Pleomorphic rhabdomyosarcoma (RMS) is a rare tumor with an aggressive behavior, described mainly in adulthood. Herein we present two cases of paratesticular pleomorphic RMS in 71- and 16-year-old patients with metastases at initial diagnosis. Histological, immunohistochemical, and ultrastructural findings were essential to confirm diagnosis. Few months after radical orchiectomy, both patients died before or just after starting adjuvant chemotherapy.

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[621]

TÍTULO / TITLE:  - Infarcted fibroadenoma of the breast: report of two new cases with review of the  literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2013 Feb 27;8:38. doi: 10.1186/1746-1596-8-38.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-8-38

AUTORES / AUTHORS:  - Skenderi F; Krakonja F; Vranic S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Clinical Center of the University of Sarajevo, Bolnicka  25, Sarajevo, BA-71000, Bosnia and Herzegovina. semir.vranic@gmail.com.

RESUMEN / SUMMARY:  - INTRODUCTION: Fibroadenomas are the most common benign breast tumors in young women. Infarction is rarely observed in fibroadenomas and when present, it is usually associated with pregnancy or lactation. Infarction can exceptionally occur as a complication of previous fine-needle aspiration biopsy or during lactation and pregnancy. MATERIALS AND METHODS: Retrospective review of 650 cases of fibroadenomas diagnosed at our institution during the 8-years period identified two cases of fibroadenomas with infarction (rate ~0.3%). RESULTS: Two  partially infarcted fibroadenomas were diagnosed on core biopsy and frozen section in an adolescent girl (13 years old) and in a young woman (25 years old), respectively. No preceding fine-needle aspiration biopsy was performed in these cases, nor were the patients pregnant or lactating at the time of the diagnosis.  CONCLUSION: Spontaneous infarction within fibroadenoma is a rare phenomenon in younger patients. The presence of necrosis on core biopsy or frozen section should be cautiously interpreted and is not a sign of malignancy. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: diagnosticpathology.diagnomx.eu/vs/1556060549847356.

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[622]

TÍTULO / TITLE:  - Primary intimal (spindle cell) sarcoma of the heart: a case report and review of  the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Med. 2013;2013:461815. doi: 10.1155/2013/461815. Epub 2013 Jan 28.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/461815

AUTORES / AUTHORS:  - Ibrahim A; Luk A; Singhal P; Wan B; Zavodni A; Cusimano RJ; Butany J

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Toronto General Hospital, University Health Network, Toronto, ON, Canada M5G 2C4.

RESUMEN / SUMMARY:  - Intimal (spindle cell) sarcomas of the left atrium are extremely rare primary cardiac tumours with three cases reported (Li et al. (2013), Cho et al. (2006), and Modi et al. (2009)). We present a 69-year-old man who first came to medical attention after experiencing abdominal discomfort. He had a 30 lb weight loss apparently due to dieting. He denied any other constitutional symptoms. His symptoms persisted despite a course of antibiotics for presumed diverticulitis. Laboratory values were within normal limits, though the haemoglobin was 131 g/L (normal: 140-180). Subsequent abdominal computed tomography (CT) scan revealed an abdominal wall mass and intracardiac lesion; the cardiac mass was further characterized by transesophageal echo (TEE), magnetic resonance imaging (MRI), and dedicated cardiac CT. TEE revealed a mass attached to the posterolateral wall of the left atrium above the mitral annulus, and the cardiac CT and MRI confirmed the TEE findings. The patient underwent extensive surgical resection and repair of the left side of the heart. Postoperatively, he developed acute renal failure  requiring dialysis and reintubation for volume overload. He became acutely hypotensive, developed multiorgan failure, and succumbed to his illness. Histopathologic examination of the left atrial mass showed an intimal sarcoma.

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[623]

TÍTULO / TITLE:  - Chondroblastoma associated with aneurysmal cyst of the navicular bone: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Feb 28;11:50. doi: 10.1186/1477-7819-11-50.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-50

AUTORES / AUTHORS:  - Fang Z; Chen M

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, PuAi Hospital, affiliated to TongJi medical college, HuaZhong University of Science and Technology, Hanzheng Jie No, 473, Qiaokou District, 430033, Wuhan, China. cm19720@163.com.

RESUMEN / SUMMARY:  - Chondroblastoma is a rare tumor. It is usually benign; however, it can have an aggressive course before or after operative treatment, even resulting in pulmonary metastases. The foot is a rare location for chondroblastoma, and to our knowledge, chondroblastoma occurring in the navicular bone has not been reported  previously in the English literature. We describe a case of navicular chondroblastoma case associated with an aneurysmal bone cyst. Treatment consisted of aggressive curettage, phenolization, and bone allograft. The patient was able  to resume normal activities after treatment, and there was no recurrence of the chondroblastoma during a follow-up of 3 years.

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[624]

TÍTULO / TITLE:  - Desmoplastic Fibroblastoma Presenting as a Parotid Tumour: A Case Report and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Head Neck Pathol. 2013 Mar 16.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12105-013-0435-2

AUTORES / AUTHORS:  - Nagaraja V; Coleman HG; Morgan GJ

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Westmead Hospital, Unit19 7-9 Queens Road, Westmead, Sydney, NSW, 2145, Australia, vinayaknraj@gmail.com.

RESUMEN / SUMMARY:  - Desmoplastic fibroblastomas (DFs) are rare fibrous soft tissue tumours that usually arise in subcutaneous tissue or skeletal muscle in a variety of anatomical sites. These lesions most frequently present as painless, slow-growing mobile masses. A case of DF is described in a 47-year-old man who presented with  a painless right parotid mass of 2 months duration. At surgery, the lesion was attached to the tail of the right parotid gland. Histopathological examination demonstrated a fibrous lesion comprising spindled and stellate shaped fibroblasts with focal myxoid stromal change. The features were consistent with a DF. This report documents a rare parotid lesion which may mimic other more common parotid  gland neoplasms.

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[625]

TÍTULO / TITLE:  - Parapharyngeal liposarcoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2013 Mar 7;8:42. doi: 10.1186/1746-1596-8-42.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-8-42

AUTORES / AUTHORS:  - Li H; Zhou X; Ran Q; Wang L

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology and Head-Neck Surgery, Xinqiao Hospital, PLA, Third Military Medical University, Chongqing, PR, 400037, China. leehong7118@yahoo.com.cn.

RESUMEN / SUMMARY:  - BACKGROUND: Parapharyngeal liposarcoma is a very rare malignant tumor that often  causes nonspecific clinical symptoms, such as progressive dysphagia, globus sensation and/or respiratory disturbances. The combination of radiological imaging techniques and histopathological analysis provides information for diagnosis; however, the pathogenesis is still uncertain. CASE PRESENTATION: A 30-year-old male patient presented with a pharyngeal cavity mass, which had been  present for 2 years. The clinical syndrome included obstructive sleep apnea symptoms (i.e., respiratory disturbances, excessive daytime somnolence, and headache) and difficulty swallowing. The radiological examination (CT) demonstrated that there was a low-density irregular solid lesion on the posterior wall of the oropharynx and laryngopharynx, which descended to the superior mediastinum and extended to the left parapharyngeal space and sternocleidomastoid muscle. The boundaries of the lesion were clear, and the lesion’s density was nonuniform. Several septations inside the lesion were observed. The CT values of  the lesion at the epiglottis and the vocal folds were 11 HU and minus 30 HU, respectively. After enhanced scanning, there was no apparent enhancement of the lesion: the surrounding tissue and blood vessels were squeezed and shifted, but the neighboring sclerotin of the cervical vertebrae was not invaded. The mass was removed via a transcervical approach, resulting in a complete amelioration of the patient’s symptoms. Interestingly, immunohistochemistry showed that the tumor cells expressed members of the B7 superfamily, including B7-H1, B7-DC and B7-H3.  In addition, the expression of TIM-containing molecules, including TIM-3 and TIM-4, was observed. CONCLUSIONS: CT and MRI demonstrated that the mass was a parapharyngeal liposarcoma. Furthermore, carcinoma-associated B7 and TIM-containing molecules were observed in the tissue, indicating that these molecules are most likely active in the pathogenesis of this disease. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: diagnosticpathology.diagnomx.eu/vs/1907794973876202.

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[626]

TÍTULO / TITLE:  - Pancreatic carcinosarcoma: case report of a rare type of pancreatic neoplasia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JOP. 2013 Mar 10;14(2):212-5. doi: 10.6092/1590-8577/1309.

AUTORES / AUTHORS:  - Oymaci E; Argon A; Coskun A; Ucar AD; Carti E; Erkan N; Yildirim M

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, Izmir Bozyaka Training and Research Hospital. Izmir, Turkey. erkan.oymaci@hotmail.com.

RESUMEN / SUMMARY:  - CONTEXT: Carcinosarcoma of the pancreas is a rare entity comprising a small subset of all pancreatic neoplasms. Diagnosis is usually established by immunohistochemical examination of the resected specimen. Prognosis is limited to several months after resection. CASE REPORT: We review the current literature on  this rare type of neoplasia, considering histopathological and clinical features. The pathologic findings revealed areas of both adenocarcinoma and sarcoma of the  pancreas. The adenocarcinomatous areas localized to the tumor within the head of  the pancreas whereas the sarcomatous areas localized to regions of the intraductal component. DISCUSSION: Carcinosarcoma of the pancreas is a rare disease having a dismal prognosis. To our knowledge, this carcinosarcoma is the very rare reported case of a primary pancreatic neoplasm with mixed carcinomatous and sarcomatous components.

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[627]

TÍTULO / TITLE:  - Angioleiomyoma in a rare location: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hawaii J Med Public Health. 2013 Feb;72(2):45-8.

AUTORES / AUTHORS:  - Willoughby AD; Schlussel AT; Freeman JH; Lin-Hurtubise K

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, Tripler Army Medical Center, Honolulu, HI (A.D.W., A.T.S., K.L-H).

RESUMEN / SUMMARY:  - A case report of a 38-year-old man with a 10 year history of left buttock mass associated with pain and numbness. A computed tomography scan showed a subcutaneous enhancing 1cm lesion that was not communicating with surrounding structures to include neurovascular structures. The mass was removed without complication and sent to pathology for extensive review. This case report signifies the importance of maintaining a broad differential with a subcutaneous  mass presentation and includes thorough histology and pathology for angioleiomyoma.

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[628]

TÍTULO / TITLE:  - Submandibular myofibroma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oral Maxillofac Surg. 2013 Feb 13.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10006-013-0388-3

AUTORES / AUTHORS:  - Heitz C; de Barros Berthold RC; Machado HH; Sant’ana L; de Oliveira RB

INSTITUCIÓN / INSTITUTION:  - Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do  Sul, Brazil, profheitz@hotmail.com.

RESUMEN / SUMMARY:  - PURPOSE: Myofibroma is a rare benign spindle cell neoplasm, and the aim of the present study was to carry out a literature review and present a clinical case of a patient with a myofibroma in the submandibular region and its management. CONCLUSIONS: Diagnosis of myofibroma can be reached by a histopathologic and immunohistochemical analysis and surgical excision is the treatment of choice.

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[629]

TÍTULO / TITLE:  - An unusual cause for trismus caused by mandibular coronoid osteoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Imaging Sci Dent. 2013 Mar;43(1):45-8. doi: 10.5624/isd.2013.43.1.45. Epub 2013 Mar 11.

            ●● Enlace al texto completo (gratuito o de pago) 5624/isd.2013.43.1.45

AUTORES / AUTHORS:  - Vashishth S; Garg K; Patil P; Sreenivasan V

INSTITUCIÓN / INSTITUTION:  - Department of Oral Medicine and Radiology, Subharati Dental College, Meerut, India.

RESUMEN / SUMMARY:  - Osteoma is a dense bony proliferation of otherwise normal membranous bone. This tumor is essentially restricted to the craniofacial skeleton and is rarely diagnosed in other bones. The mandible and the paranasal sinuses are the most common sites, while the involvement of the coronoid process has been reported in  only 6 cases so far. This report demonstrated a case of osteoma occurring at the  mandibular coronoid process in a 26-year-old female patient. The patient was managed with surgical resection of the osteoma followed by physiotherapy.

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[630]

TÍTULO / TITLE:  - Giant lipoma of the thigh: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Ultrasound. 2012 Jun;15(2):124-6. doi: 10.1016/j.jus.2012.02.010. Epub 2012 Mar 7.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jus.2012.02.010

AUTORES / AUTHORS:  - Righi A; Pantalone O; Tagliaferri G

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, San Paolo Hospital, Civitavecchia, Roma, Italy.

RESUMEN / SUMMARY:  - A lipoma is a benign tumor which can occur in any part of the body; it is very frequent and can reach a considerable size. Differentiation between lipoma and liposarcoma of low grade malignancy represents an important diagnostic problem, and valuable help in the differential diagnosis is provided by ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), biopsy and/or modern immunohistochemistry. The authors report the case of a 50-year-old man who was referred to their department due to the presence of a large mass growing on the upper thigh of the right leg; over 7 years it had steadily increased in size  causing pain and functional impotence. US of the soft tissues and CT scanning were performed. Densitometric values of the mass suggested adipose tissue, which  was subsequently confirmed by biopsy.

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[631]

TÍTULO / TITLE:  - Lipoma within Inverted Meckel’s Diverticulum: A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Pathol. 2013 Feb;47(1):86-8. doi: 10.4132/KoreanJPathol.2013.47.1.86. Epub 2013 Feb 25.

            ●● Enlace al texto completo (gratuito o de pago) 4132/KoreanJPathol.2013.47.1.86

AUTORES / AUTHORS:  - Kim SM; Jung MJ; Kim YO

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.

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[632]

TÍTULO / TITLE:  - A 35-year-old woman presenting with an unusual post-traumatic leiomyoma of the nipple: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Case Rep. 2013 Feb 19;7(1):49. doi: 10.1186/1752-1947-7-49.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1752-1947-7-49

AUTORES / AUTHORS:  - Pavlidis L; Vakirlis E; Spyropoulou GA; Pramateftakis MG; Dionyssiou D; Demiri E

INSTITUCIÓN / INSTITUTION:  - Plastic Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital Thessaloniki, Thessaloniki, Greece. leopavlidis@gmail.com.

RESUMEN / SUMMARY:  - INTRODUCTION: Leiomyoma of the mammary papilla is one of the most uncommon nipple tumors with only 50 cases reported in the literature until now. To the best of our knowledge we present the first report of a nipple leiomyoma that originated from a traumatic abrasion caused by breastfeeding. CASE PRESENTATION: A 35-year-old healthy Caucasian female with a cauliflower-like tender and pink nodular mass that was approximately 10mm in diameter presented to our out-patients department. The patient suggested that the mass originated from a traumatic abrasion caused by breastfeeding three years ago and it has been slowly growing ever since.An excision biopsy was performed. The histological and immunohistochemical examination confirmed the diagnosis of leiomyoma. There were  no postoperative complications or any sign of local recurrence four years postoperatively. CONCLUSIONS: Leiomyoma of the mammary papilla is a rare benign neoplasm that usually appears as a solid tender nodule. Differential diagnosis comprises breast carcinoma, leiomyosarcoma and myoid hamartoma. The recommended treatment is complete excision of the tumor with histologically confirmed tumor-free margins otherwise recurrence is possible. A detailed history of the patient’s disease can reveal the original etiology. This is an original case report that will have particular interest to plastic surgeons, dermatologists, and pathologists. The pathogenetic mechanism was trauma of the nipple. According  to our review of the literature this particular information has never been reported and we think that it may advance our knowledge of this very infrequent tumor.

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[633]

TÍTULO / TITLE:  - Primary angiosarcoma of breast: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Case Rep. 2013;4(4):362-4. doi: 10.1016/j.ijscr.2013.01.016. Epub 2013 Jan 30.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2013.01.016

AUTORES / AUTHORS:  - Bhosale SJ; Kshirsagar AY; Patil MV; Wader JV; Nangare N; Patil PP

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Krishna Institute of Medical Sciences, Karad 415 110, Maharashtra, India.

RESUMEN / SUMMARY:  - INTRODUCTION: Primary breast angiosarcoma is a rare form of breast cancer, accounting for only 0.04% of all malignant breast tumours. PRESENTATION OF CASE:  A 28-year-old woman presented with a progressive lump in the right breast for one month. Fine needle aspiration cytology (FNAC) was highly suspicious of angiosarcoma, and this diagnosis was confirmed on core needle biopsy. Modified radical mastectomy was performed as sole treatment. DISCUSSION: Primary breast angiosarcoma is a rare type of breast malignancy, usually occurring in the third  to fourth decade and only reported in women. The histological features of angiosarcoma of the breast are conventionally graded I, II or III. Total mastectomy appears to be the only treatment conferring benefit, chemotherapy and  radiation therapy being of little proven value to date. The 5-year disease-free survival for grade I tumours can be as high as 76%, and up to 70% for grade II tumours whereas for grade III tumours it is reportedly about 15%. CONCLUSION: Primary angiosarcoma of the breast is a rare malignancy with a poor prognosis, even after complete resection. Surgery is the mainstay of treatment with a limited role for chemotherapy and radiotherapy.

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[634]

TÍTULO / TITLE:  - Elastofibroma dorsi: case series of a rare benign tumour of the back.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Orthop Surg Traumatol. 2012 Aug 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00590-012-1064-2

AUTORES / AUTHORS:  - Giannotti S; Bottai V; Dell’osso G; Bugelli G; Cazzella N; Guido G

INSTITUCIÓN / INSTITUTION:  - Universita’ Di Pisa II Clinica Ortopedica E Traumatologica, Via Paradisa 2, Pisa, Italy, s.giannotti@med.unipi.it.

RESUMEN / SUMMARY:  - We analyse this rare pseudotumour with few case reports in the orthopaedic literature. Elastofibroma dorsi is an uncommon benign soft tissue pseudotumour usually located at the lower pole of the scapula. This study is a clinical assessment of 5 patients. All the patients had their diagnosis based on clinical  and MRI findings and had excision biopsy. The patients were followed for a mean period of 24 months. No patient had residual symptoms. We have only one recurrence. Surgical excision is recommended when it causes functional disability, compression symptoms, an asymmetric outline of the chest wall, or when it is more than 5 cm in diameter. Pre-operative tissue diagnosis is not necessary in most cases. Despite its rarity, the elastofibroma dorsi should always be suspected with the emergence of a swelling in the subscapularis, especially in females and in old age.

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[635]

TÍTULO / TITLE:  - Specific Biomimetic Hydroxyapatite Nanotopographies Enhance Osteoblastic Differentiation and Bone Graft Osteointegration.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tissue Eng Part A. 2013 Mar 19.

            ●● Enlace al texto completo (gratuito o de pago) 1089/ten.TEA.2012.0560

AUTORES / AUTHORS:  - Loiselle AE; Wei L; Faryad M; Paul EM; Lewis GS; Gao J; Lakhtakia A; Donahue HJ

INSTITUCIÓN / INSTITUTION:  - Penn State College of Medicine, Orthopaedics and Rehabilitation, Hershey, Pennsylvania, United States ; aloiselle@hmc.psu.edu.

RESUMEN / SUMMARY:  - Impaired healing of cortical bone grafts represents a significant clinical problem. Cadaveric bone grafts undergo extensive chemical processing to decrease  the risk of disease transmission, however, these processing techniques alter the  bone surface and decrease the osteogenic potential of cells at the healing site.  Extensive work has been done to optimize the surface of bone grafts and hydroxyapatite (HAP) and nanotopography both increase osteoblastic differentiation. HAP is the main mineral component of bone and can enhance osteoblastic differentiation and bone implant healing in vivo, while nanotopography can enhance osteoblastic differentiation, adhesion and proliferation. This is the first study to test the combined effects of HAP and nanotopographies on bone graft healing. With the goal of identifying optimized surface features to improve bone graft healing, we tested the hypothesis that HAP based nanotopographic resurfacing of bone grafts improves integration of cortical bone grafts by enhancing osteoblastic differentiation. Here we show that osteoblastic cells cultured on processed bones coated with specific-scale (50-60nm) HAP nanotopographies display increased osteoblastic differentiation compared to cells on un-coated bone, bones coated with Poly-L-Lactic Acid (PLLA)  nanotopographies, or other HAP nanotopographies. Furthermore, bone grafts coated  with 50-60nm HAP exhibited increased formation of new bone and improved healing,  with mechanical properties equivalent to live autografts. These data indicate the potential for specific HAP nanotopographies to not only increase osteoblastic differentiation but also improve bone graft incorporation, which could significantly increase patient quality of life following traumatic bone injuries  or resection of an osteosarcoma.

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[636]

TÍTULO / TITLE:  - An integrative genomic and transcriptomic analysis reveals potential targets associated with cell proliferation in uterine leiomyomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(3):e57901. doi: 10.1371/journal.pone.0057901. Epub 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0057901

AUTORES / AUTHORS:  - Cirilo PD; Marchi FA; Barros Filho Mde C; Rocha RM; Domingues MA; Jurisica I; Pontes A; Rogatto SR

INSTITUCIÓN / INSTITUTION:  - Department of Genetics, Institute of Biosciences, UNESP - Sao Paulo State University, Botucatu, Sao Paulo, Brazil ; CIPE - NeoGene Laboratory, AC Camargo Hospital, Fundacao Antonio Prudente, Sao Paulo, Sao Paulo, Brazil.

RESUMEN / SUMMARY:  - BACKGROUND: Uterine Leiomyomas (ULs) are the most common benign tumours affecting women of reproductive age. ULs represent a major problem in public health, as they are the main indication for hysterectomy. Approximately 40-50% of ULs have non-random cytogenetic abnormalities, and half of ULs may have copy number alterations (CNAs). Gene expression microarrays studies have demonstrated that cell proliferation genes act in response to growth factors and steroids. However, only a few genes mapping to CNAs regions were found to be associated with ULs. METHODOLOGY: We applied an integrative analysis using genomic and transcriptomic  data to identify the pathways and molecular markers associated with ULs. Fifty-one fresh frozen specimens were evaluated by array CGH (JISTIC) and gene expression microarrays (SAM). The CONEXIC algorithm was applied to integrate the  data. PRINCIPAL FINDINGS: The integrated analysis identified the top 30 significant genes (P<0.01), which comprised genes associated with cancer, whereas the protein-protein interaction analysis indicated a strong association between FANCA and BRCA1. Functional in silico analysis revealed target molecules for drugs involved in cell proliferation, including FGFR1 and IGFBP5. Transcriptional and protein analyses showed that FGFR1 (P = 0.006 and P<0.01, respectively) and IGFBP5 (P = 0.0002 and P = 0.006, respectively) were up-regulated in the tumours  when compared with the adjacent normal myometrium. CONCLUSIONS: The integrative genomic and transcriptomic approach indicated that FGFR1 and IGFBP5 amplification, as well as the consequent up-regulation of the protein products, plays an important role in the aetiology of ULs and thus provides data for potential drug therapies development to target genes associated with cellular proliferation in ULs.

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[637]

TÍTULO / TITLE:  - Multimodality imaging of aortic valve fibroelastoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Heart J Cardiovasc Imaging. 2013 Mar 10.

            ●● Enlace al texto completo (gratuito o de pago) 1093/ehjci/jet032

AUTORES / AUTHORS:  - Saboo SS; Chatzizisis YS; Khandelwal A; Bolman RM 3rd; Steigner M

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School, 70 Francis Street, Boston, MA, USA.

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[638]

TÍTULO / TITLE:  - A comparison of cell-cycle markers in skull base and sacral chordomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World Neurosurg. 2013 Feb 14. pii: S1878-8750(13)00319-7. doi: 10.1016/j.wneu.2013.01.131.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.wneu.2013.01.131

AUTORES / AUTHORS:  - Yakkioui Y; Temel Y; Creytens D; Jahanshahi A; Fleischeuer R; Santegoeds RG; Van Overbeeke JJ

INSTITUCIÓN / INSTITUTION:  - Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands; European Graduate School of Neuroscience, Maastricht, The Netherlands; School for Oncology and Developmental Biology, Maastricht, The Netherlands.

RESUMEN / SUMMARY:  - OBJECTIVE: Despite refinement of surgical techniques and adjuvant radiotherapy ,  the prognosis for patients suffering from a chordoma remains poor. Identification of prognostic factors related to tumor biology might improve this assessment and  result in molecular markers for targeted therapy. Limited studies have been performed to unravel the impact of cell cycle markers in chordoma and those performed have shown inconclusive results. In the current study, we aimed at discovering the impact of cyclin dependent kinase 4 (CDK4) expression and its relation to prognosis and other cell cycle markers in chordoma. METHODS: Twenty-five human formalin fixed paraffin-embedded chordoma specimens were examined by immunohistochemistry for the expression of CDK4, protein 53 (p53) and murine double minute 2 (MDM2). The MIB-1 labeling index (MIB1-LI) and mitotic index (MI) were used for the examination of proliferation. We collected detailed  demographic and clinical data. RESULTS: Overexpression of CDK4, p53 and MDM2 were found in 5 (20%), 7 (28%) and 14 (56%) of the cases, respectively. All three cell cycle markers showed a significant correlation with MIB1-LI. Expression of CDK4 (p=0.02) and P53 (p<0.01) were both significantly correlated to poor overall survival (OS). Also, histologically observed necrosis (p<0.05) and a dedifferentiated tumor subtype (p<0.01) were related to adverse patient outcome.  CONCLUSION: Our results show that the expression of CDK4 and p53 are linked to cell proliferation capacity and worse outcome in patients with chordoma.

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[639]

TÍTULO / TITLE:  - Surgical guides (patient-specific instruments) for pediatric tibial bone sarcoma  resection and allograft reconstruction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2013;2013:787653. doi: 10.1155/2013/787653. Epub 2013 Mar 4.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/787653

AUTORES / AUTHORS:  - Bellanova L; Paul L; Docquier PL

INSTITUCIÓN / INSTITUTION:  - Computer-Assisted Robotic Surgery (CARS), Institut de Recherche Experimentale et  Clinique (IREC), Tour Pasteur +4, Avenue Mounier 53, 1200 Brussels, Belgium ; Department of Orthopaedic Surgery, Cliniques Universitaires Saint-Luc, (Universite Catholique de Louvain), Avenue Hippocrate 10, 1200 Brussels, Belgium.

RESUMEN / SUMMARY:  - To achieve local control of malignant pediatric bone tumors and to provide satisfactory oncological results, adequate resection margins are mandatory. The local recurrence rate is directly related to inappropriate excision margins. The  present study describes a method for decreasing the resection margin width and ensuring that the margins are adequate. This method was developed in the tibia, which is a common site for the most frequent primary bone sarcomas in children. Magnetic resonance imaging (MRI) and computerized tomography (CT) were used for preoperative planning to define the cutting planes for the tumors: each tumor was segmented on MRI, and the volume of the tumor was coregistered with CT. After preoperative planning, a surgical guide (patient-specific instrument) that was fitted to a unique position on the tibia was manufactured by rapid prototyping. A second instrument was manufactured to adjust the bone allograft to fit the resection gap accurately. Pathologic evaluation of the resected specimens showed  tumor-free resection margins in all four cases. The technologies described in this paper may improve the surgical accuracy and patient safety in surgical oncology. In addition, these techniques may decrease operating time and allow for reconstruction with a well-matched allograft to obtain stable osteosynthesis.

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[640]

TÍTULO / TITLE:  - Mucosal Cutting Biopsy Technique for Histological Diagnosis of Suspected Gastrointestinal Stromal Tumors of the Stomach.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dig Endosc. 2012 Nov 8. doi: 10.1111/j.1443-1661.2012.01384.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1443-1661.2012.01384.x

AUTORES / AUTHORS:  - Kataoka M; Kawai T; Yagi K; Sugimoto H; Yamamoto K; Hayama Y; Nonaka M; Aoki T; Fukuzawa M; Fukuzawa M; Itoi T; Moriyasu F

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology and Hepatology, International University of Health And Welfare Mita Hospital, Tokyo, Japan; Department of Gastroenterology and Hepatology, Tokyo Medical University Hospital, Tokyo, Japan.

RESUMEN / SUMMARY:  - BACKGROUND AND AIM: The Japanese Gastrointestinal Stromal Tumor (GIST) therapeutic guidelines recommend endoscopic ultrasound-guided fine-needle aspiration biopsy for histological diagnosis. However, before 2010, this technique was only carried out at a minority of medical institutions in Japan. In the present study, we investigated the usefulness of mucosal cutting biopsy. METHODS: In 18 asymptomatic gastric submucosal tumors, mucosal cutting biopsies were carried out. We examined tumor size, tumor site (lower third: L; middle third: M; upper third: U), histopathological diagnostic yield and complications.  In cases that proceeded to surgical resection with a diagnosis of GIST, we compared the pre- and postoperative histopathological diagnosis, and the histological degrees of malignancy. RESULTS: The tumors had a mean size of 20.3 mm and were located at the L site in five cases, M in four, and U in nine. Histological diagnosis of submucosal tumor was obtained in all the cases. (GIST,  n = 13; heterotopic pancreas, n = 2; and leiomyoma, n = 3). No complications (e.g. bleeding, perforation or peritonitis) were seen after this procedure. In all 11 patients with GIST who underwent surgical resection, the histopathological findings from the mucosal cutting biopsy specimens were similar to those from the surgically resected specimens, with agreement between the immunostaining findings and the histological degree of malignancy (90.9%) in 10 patients. CONCLUSIONS: The mucosal cutting biopsy technique is a useful diagnostic modality for the diagnosis of gastric GIST and for selection of the appropriate treatment.

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[641]

TÍTULO / TITLE:  - Histiocytic sarcoma of the nasal cavity in a horse.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Res Vet Sci. 2013 Feb 5. pii: S0034-5288(13)00007-6. doi: 10.1016/j.rvsc.2013.01.005.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.rvsc.2013.01.005

AUTORES / AUTHORS:  - Paciello O; Passantino G; Costagliola A; Papparella S; Perillo A

INSTITUCIÓN / INSTITUTION:  - Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy. Electronic address: paciello@unina.it.

RESUMEN / SUMMARY:  - Histiocytic diseases in veterinary medicine have been revised in the last few decades, but these are considered relatively rare in horses. This report describes a 9-year-old female horse, Dutch Warmblood, presented for investigation of severe nasal bleeding. A multinodular bilateral mass of 5cm, reddish to white  in color, that invaded and destroyed the surrounding tissues, was observed during a clinical examination of the nostril The morphological features of the tumor cells were represented by cytologically bizarre, highly phagocytic, multinucleated giant cells. These findings, together with immunohistochemical results allowed a diagnosis of histiocytic sarcoma.

 

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[642]

TÍTULO / TITLE:  - Radiation-induced sarcoma in spine.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pol J Radiol. 2013 Jan;78(1):69-71. doi: 10.12659/PJR.883770.

            ●● Enlace al texto completo (gratuito o de pago) 12659/PJR.883770

AUTORES / AUTHORS:  - Kam LS; Anthony MP; Shek H

INSTITUCIÓN / INSTITUTION:  - The University of Hong Kong, Hong Kong, China.

RESUMEN / SUMMARY:  - Although radiotherapy is a part of treatment in cancers, it can also induce malignancy as a late complication. The presence of radiation-induced sarcomas in  bone, although not very common, is acknowledged. The onset of radiation-induced sarcoma in the spine however, is not well recognized. We present here a case of radiation-induced fibrosarcoma in the T1 lamina and spinous process in a patient  with a history of breast cancer treated with radiotherapy 30 years prior.

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[643]

TÍTULO / TITLE:  - Inhibition of Growth and Induction of Apoptosis in Fibrosarcoma Cell Lines by Echinophora platyloba DC: In Vitro Analysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Adv Pharmacol Sci. 2013;2013:512931. doi: 10.1155/2013/512931. Epub 2013 Jan 14.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/512931

AUTORES / AUTHORS:  - Shahneh FZ; Valiyari S; Azadmehr A; Hajiaghaee R; Yaripour S; Bandehagh A; Baradaran B

INSTITUCIÓN / INSTITUTION:  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

RESUMEN / SUMMARY:  - Echinophora platyloba DC plant (Khousharizeh) is one of the indigenous medicinal  plants which is used as a food seasoning and medicine in Iran. The objective of this study was to examine the in vitro cytotoxic activity and the mechanism of cell death of crude methanolic extracts prepared from Echinophora platyloba DC, on mouse fibrosarcoma cell line (WEHI-164). Cytotoxicity and viability of methanolic extract was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and dye exclusion assay. Cell death ELISA was employed to quantify the nucleosome production result from nuclear DNA fragmentation during apoptosis and determine whether the mechanism involves induction of apoptosis or necrosis. The cell death was identified as apoptosis using terminal deoxynucleotidyl transferase- (TdT-) mediated dUTP nick end labeling (TUNEL) assay. Our results demonstrated that the  extract decreased cell viability, suppressed cell proliferation, and induced cell death in a time- and dose-dependent manner in WEHI-164 cells (IC50 = 196.673 +/-  12.4 mug/mL) when compared with a chemotherapeutic anticancer drug, Toxol. Observation proved that apoptosis was the major mechanism of cell death. So the Echinophora platyloba DC extract was found to time- and dose-dependently inhibit  the proliferation of fibrosarcoma cell possibly via an apoptosis-dependent pathway.

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[644]

TÍTULO / TITLE:  - Chordoma characterization of significant changes of the DNA methylation pattern.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(3):e56609. doi: 10.1371/journal.pone.0056609. Epub 2013 Mar 22.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0056609

AUTORES / AUTHORS:  - Rinner B; Weinhaeusel A; Lohberger B; Froehlich EV; Pulverer W; Fischer C; Meditz K; Scheipl S; Trajanoski S; Guelly C; Leithner A; Liegl B

INSTITUCIÓN / INSTITUTION:  - Center for Medical Research, Medical University Graz, Graz, Austria.

RESUMEN / SUMMARY:  - Chordomas are rare mesenchymal tumors occurring exclusively in the midline from clivus to sacrum. Early tumor detection is extremely important as these tumors are resistant to chemotherapy and irradiation. Despite continuous research efforts surgical excision remains the main treatment option. Because of the often challenging anatomic location early detection is important to enable complete tumor resection and to reduce the high incidence of local recurrences. The aim of this study was to explore whether DNA methylation, a well known epigenetic marker, may play a role in chordoma development and if hypermethylation of specific CpG islands may serve as potential biomarkers correlated with SNP analyses in chordoma. The study was performed on tumor samples from ten chordoma  patients. We found significant genomic instability by Affymetrix 6.0. It was interesting to see that all chordomas showed a loss of 3q26.32 (PIK 3CA) and 3q27.3 (BCL6) thus underlining the potential importance of the PI3K pathway in chordoma development. By using the AITCpG360 methylation assay we elucidated 20 genes which were hyper/hypomethylated compared to normal blood. The most promising candidates were nine hyper/hypomethylated genes C3, XIST, TACSTD2, FMR1, HIC1, RARB, DLEC1, KL, and RASSF1. In summary, we have shown that chordomas are characterized by a significant genomic instability and furthermore we demonstrated a characteristic DNA methylation pattern. These findings add new insights into chordoma development, diagnosis and potential new treatment options.

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[645]

TÍTULO / TITLE:  - Multiple splice variants of EWSR1-ETS fusion transcripts co-existing in the Ewing sarcoma family of tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cell Oncol (Dordr). 2013 Mar 14.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13402-013-0126-8

AUTORES / AUTHORS:  - Patocs B; Nemeth K; Garami M; Arato G; Kovalszky I; Szendroi M; Fekete G

INSTITUCIÓN / INSTITUTION:  - 2nd Department of Paediatrics, Semmelweis University, Tuzolto u. 7-9, Budapest, 1094, Hungary, barbarapatocs@gmail.com.

RESUMEN / SUMMARY:  - PURPOSE: The Ewing sarcoma family of tumors (EFT) is characterized by fusions of  the EWSR1 gene on chromosome 22q12 with either one of the genes encoding members  of the ETS family of transcription factors, in the majority of cases FLI1 or ERG. Many alternative EWSR1-ETS gene fusions have been encountered, due to variations  in the locations of the EWSR1 and ETS genomic breakpoints. The resulting heterogeneity in EWSR1-ETS fusion transcripts may further be increased by the occurrence of multiple splice variants within the same tumor. Here we present a retrospective study designed to detect all of the EWSR1-FLI1 and EWSR1-ERG fusion transcripts in a series of 23 fresh frozen EFT tissues. METHODS: RT-PCR and nested fluorescent multiplex PCR were used to amplify EWSR1-FLI1 and EWSR1-ERG transcripts from EFT tissues. Fusion transcripts were identified by laser-induced fluorescent capillary electrophoresis and confirmed by sequence analysis. RESULTS: Nine different EWSR1-FLI1 fusion transcripts and one EWSR1-ERG fusion transcript were identified in 21 out of 23 fresh frozen EFT tissue samples. In five cases multiple fusion transcripts were found to coexist in the same tumor sample. We additionally reviewed previous reports on twelve cases with multiple EWSR1-ETS fusion transcripts. CONCLUSIONS: Alternative splicing may frequently affect the process of EFT-associated fusion gene transcription and, as such, may  significantly contribute to the pathogenic role of EFT-associated chromosome translocations. In a considerable number of cases this may result in multiple splice variants within the same tumor.

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[646]

TÍTULO / TITLE:  - Functional Results Following Vascularized Versus Nonvascularized Bone Grafts for  Wrist Arthrodesis Following Excision of Giant Cell Tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Hand Surg Am. 2013 Feb 27. pii: S0363-5023(12)01840-0. doi: 10.1016/j.jhsa.2012.12.026.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jhsa.2012.12.026

AUTORES / AUTHORS:  - Clarkson PW; Sandford K; Phillips AE; Pazionis TJ; Griffin A; Wunder JS; Ferguson PC; Masri BA; Goetz T

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, University of British Columbia, Vancouver, British Columbia; Department of Orthopaedics, McMaster University, Hamilton, Ontario; Division of Orthopaedic Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address: pclarkson@bccancer.bc.ca.

RESUMEN / SUMMARY:  - PURPOSE: Wrist arthrodesis after resection of a giant cell tumor of the distal radius can be performed using a vascularized free fibular transfer (VFFT) or a nonvascularized structural iliac crest transfer (NICT). The purpose of this study was to compare the union times, functional outcomes, and complications after these procedures. METHODS: We identified 27 patients at 2 centers: 14 underwent VFFT, and 13 NICT. The 2 groups were comparable for age, sex, and tumor grade. We assessed functional outcomes of the wrist with the Toronto Extremity Salvage Score, Musculoskeletal Tumor Society 1987 and 1993 scores, and Disabilities of the Arm, Shoulder, and Hand scores. RESULTS: Two local recurrences occurred in the VFFT group and 1 in the NICT group. The VFFT group had 3 patients who had already undergone or were planning to undergo surgery for improved appearance, hardware removal, or tendon release. In the NICT group, 2 infections required debridement, 1 of which went on to free fibular transfer, but there were no reoperations for nonunion or donor site morbidity. The surgical time was significantly shorter for NICT. Functional scores showed no differences between groups on any of the parameters studied for the upper limb. CONCLUSIONS: Both VFFT and NICT were effective surgical techniques for wrist fusion after distal radial resection for giant cell tumor. Vascularized free fibular transfer should  be considered when a major skin defect is anticipated, because it allows the inclusion of a vascularized skin paddle, or when the osseous defect is too long (> 10 cm) for NICT. We were unable to demonstrate a difference in upper limb functional scores between VFFT and NICT. Because the surgical time is significantly shorter and reoperation rate is lower for NICT, we recommend NICT whenever possible. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic III.

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[647]

TÍTULO / TITLE:  - CASE REPORT Sternal Chondrosarcoma After Sternotomy for Coronary Artery Bypass Grafting.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eplasty. 2013;13:e7. Epub 2013 Jan 24.

AUTORES / AUTHORS:  - Singh VA; Abreu J; Bowman K; Shariff MA; McGinn JT Jr

INSTITUCIÓN / INSTITUTION:  - Cardiothoracic Surgery Department.

RESUMEN / SUMMARY:  - Objective: Primary bony tumors of the chest wall are usually benign and most commonly located in the ribs or sternum. Chondrosarcoma is regarded as one of the most frequent primary malignancies of the chest wall and its incidence after a sternotomy for a cardiac procedure is extremely rare. We present a case of sternal chondrosarcoma. Methods: The patient presented with a sternal mass 4 years after undergoing coronary artery bypass grafting for ischemic coronary artery disease. The mass originally emanated from the upper portion of the patients’ sternum and then rapidly enlarged to include the anterior aspects of his neck. Radiologic imaging studies were undertaken: computed tomographic scan and magnetic resonance imaging, with surgical intervention for excision. Results: Computed tomographic scan and magnetic resonance imaging established an 8.4 x 6.2 x 8.6 cm(3) complex solid tissue mass within the lower neck arising from the sternal manubrium, with extensive bone destruction. Computed tomography-guided biopsy showed cells of uncertain significance. Surgical excision was performed and the mass was diagnosed as a grade II chondrosarcoma. Discussion: Primary sarcomas of the sternum though uncommon are potentially curable with wide surgical excision. Success depends on tumor histologic type and grade, which dictate recurrence.

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[648]

TÍTULO / TITLE:  - Iatrogenic giant cell tumor at bone graft harvesting site.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Orthop. 2013 Jan;47(1):107-10. doi: 10.4103/0019-5413.106936.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0019-5413.106936

AUTORES / AUTHORS:  - Kundu ZS; Gupta V; Sangwan SS; Goel S; Rana P

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, PGIMS, Rohtak, India.

RESUMEN / SUMMARY:  - 30 year old female patient with giant cell tumor of the distal tibia initially treated at a peripheral nononcological center by curettage and autologous bone grafting from the ipsilateral iliac crest reported to us with local recurrence and an implantation giant cell tumor at the graft harvesting site which required  extensive surgeries at both sites. The risk of iatrogenic direct implantation of  tumor, often attributable to inadequate surgical planning or poor surgical techniques, and the steps to prevent such complication is reported here.

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[649]

TÍTULO / TITLE:  - Volume changes in soft tissue sarcomas during preoperative radiotherapy of extremities evaluated using cone-beam CT.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Radiat Oncol. 2013 Mar;2(1):55-62. Epub 2013 Jan 4.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13566-012-0085-0

AUTORES / AUTHORS:  - Betgen A; Haas RL; Sonke JJ

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

RESUMEN / SUMMARY:  - The objective of this study is to quantify volume changes in the gross target volume (GTV) during preoperative radiotherapy for extremity soft tissue sarcomas  (ESTS). Twenty-seven patients with ESTS, treated with preoperative radiotherapy,  were included in this study. Weekly cone-beam CT scans acquired for setup correction were used for GTV delineation in order to quantify volume changes over the course of treatment. Age, anatomical location, tumour type and tumour volume  were evaluated as predictive factors for volume changes. Finally, the optimal time point for adaptive intervention was quantified. A GTV increase to a maximum  of 28 % occurred in five patients. Thirteen patients showed no change and nine patients (all diagnosed with myxoid liposarcoma (MLS)) showed a GTV decrease to a maximum of 57 % of the GTV volume at start of treatment. In the multivariate analysis, only the relative volume change for tumour type was significant (p = 0.001). The optimal time point for adaptive intervention in non-MLS patients was  the first week and for MLS patients the third week. Volume changes were quantified during preoperative RT of ESTS. Volume decrease was observed only in MLS patients. Individualised treatment resulting in plan adaptations could result in a clinically useful volume reduction for MLS patients.

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[650]

TÍTULO / TITLE:  - Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathogens. 2012 Dec;1(2):102-127. Epub 2012 Oct 22.

            ●● Enlace al texto completo (gratuito o de pago) 3390/pathogens1020102

AUTORES / AUTHORS:  - Zhang W; Gao SJ

INSTITUCIÓN / INSTITUTION:  - Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA90033, USA.

RESUMEN / SUMMARY:  - As obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi’s sarcoma and several other lymphoproliferative malignancies. KSHV entry into cells is tightly  regulated by diverse viral and cellular factors. In particular, KSHV actively engages cellular integrins and ubiquitination pathways for successful infection.  Emerging evidence suggests that KSHV hijacks both actin and microtubule cytoskeletons at different phases during entry into cells. Here, we review recent findings on the early events during primary infection of KSHV and its closely related primate homolog rhesus rhadinovirus with highlights on the regulation of  cellular cytoskeletons and signaling pathways that are important for this phase of virus life cycle.

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[651]

TÍTULO / TITLE:  - Intra-articular neurofibroma: an unusual source of anterior knee pain.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Orthop (Belle Mead NJ). 2012 Nov;41(11):492-5.

AUTORES / AUTHORS:  - Kelly DW; Ovanessoff SA; Rubin JP

INSTITUCIÓN / INSTITUTION:  - Attending Orthopaedic Surgeon, Phoenix Baptist Hospital, and in Private Practice, Arizona. drdougk@aol.com.

RESUMEN / SUMMARY:  - The infrapatellar fat pad of the knee is often implicated as a source of anterior knee pain. We present an unusual case of anterior knee pain in an adult patient from a solitary neurofibroma arising in an intra-articular location associated with the infrapatellar fat pad. Clinical, radiographic, magnetic resonance imaging (MRI), and histopathologic features are presented, as well as, a review of the literature. This case adds to the differential diagnosis of fat pad lesions seen on MRI and contributes to understanding the spectrum of clinical presentations of neurofibromas and pathology involving this region.

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[652]

TÍTULO / TITLE:  - Clivus Chordomas: Role of Surgery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World Neurosurg. 2013 Jan 31. pii: S1878-8750(13)00222-2. doi: 10.1016/j.wneu.2013.01.123.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.wneu.2013.01.123

AUTORES / AUTHORS:  - Guinto G; Guinto-Nishimura Y

INSTITUCIÓN / INSTITUTION:  - Professor and Chairman. Department of Neurosurgery. Hospital de Especialidades Centro Medico Nacional Siglo XXI. Member of the Centro Neurologico ABC. Mexico City, Mexico. Electronic address: gguinto@prodigy.net.mx.

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[653]

TÍTULO / TITLE:  - Understanding the cell cycle in the pathophysiology of chordomas: a molecular look.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World Neurosurg. 2013 Feb 1. pii: S1878-8750(13)00225-8. doi: 10.1016/j.wneu.2013.01.126.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.wneu.2013.01.126

AUTORES / AUTHORS:  - Kaloostian PE; Gokaslan ZL

INSTITUCIÓN / INSTITUTION:  - The Johns Hopkins Hospital, Baltimore, Maryland.

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[654]

TÍTULO / TITLE:  - Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi’s  sarcoma and P. falciparum malaria.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Front Microbiol. 2013;4:35. doi: 10.3389/fmicb.2013.00035. Epub 2013 Mar 12.

            ●● Enlace al texto completo (gratuito o de pago) 3389/fmicb.2013.00035

AUTORES / AUTHORS:  - Conant KL; Kaleeba JA

INSTITUCIÓN / INSTITUTION:  - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences Bethesda, MD, USA.

RESUMEN / SUMMARY:  - The most severe manifestations of malaria (caused by Plasmodium falciparum) occur as a direct result of parasitemia following invasion of erythrocytes by post-liver blood-stage merozoites, and during subsequent cyto-adherence of infected erythrocytes to the vascular endothelium. However, the disproportionate  epidemiologic clustering of severe malaria with aggressive forms of endemic diseases such as Kaposi’s sarcoma (KS), a neoplasm that is etiologically linked to infection with KS-associated herpesvirus (KSHV), underscores the significance  of previously unexplored co-pathogenetic interactions that have the potential to  modify the overall disease burden in co-infected individuals. Based on recent studies of the mechanisms that P. falciparum and KSHV have evolved to interact with their mutual human host, several new perspectives are emerging that highlight a surprising convergence of biological themes potentially underlying their associated co-morbidities. Against this background, ongoing studies are rapidly constructing a fascinating new paradigm in which the major host receptors that control parasite invasion (Basigin/CD147) and cyto-adherence (CD36) are, surprisingly, also important targets for exploitation by KSHV. In this article, we consider the major pathobiological implications of the co-option of Basigin/CD147 and CD36 signaling pathways by both P. falciparum and KSHV, not only as essential host factors for parasite persistence but also as important mediators of the pro-angiogenic phenotype within the virus-infected endothelial microenvironment. Consequently, the triangulation of interactions between P. falciparum, KSHV, and their mutual human host articulates a syndemic relationship that points to a conceptual framework for prevalence of aggressive forms of KS in malaria-endemic areas, with implications for the possibility of dual-use therapies against these debilitating infections in resource-limited parts of the  world.

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[655]

TÍTULO / TITLE:  - Pulmonary artery intimal sarcoma: poor 18F-fluorodeoxyglucose uptake in positron  emission computed tomography.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cardiothorac Surg. 2013 Mar 7;8:40. doi: 10.1186/1749-8090-8-40.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1749-8090-8-40

AUTORES / AUTHORS:  - Lee DH; Jung TE; Lee JH; Shin DG; Park WJ; Choi JH

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yeungnam  University, Daemyeong 5-dong, Nam-gu, Daegu, South Korea. tejung@med.yu.ac.kr.

RESUMEN / SUMMARY:  - Intimal sarcoma of the pulmonary artery is a rare malignant tumor that may be misdiagnosed as chronic pulmonary thromboembolism, even if various imaging techniques are used. We report a case of a 58-year-old man with pulmonary artery  intimal sarcoma.18F-fleuorodeoxyglucose (FDG) uptake was poor in the mass of the  pulmonary artery, and no other hypermetabolic lesions were noted elsewhere. Our presumptive diagnosis was a massive mural thrombus and a concomitant chronic thromboembolism. Intravenous heparin and recombinant human tissue-type plasminogen activator was subsequently administered. However, the patient needed  an emergency operation for sudden aggravation of the vital signs, and the tissue  diagnosis was intimal sarcoma with poor clinical outcomes.

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[656]

TÍTULO / TITLE:  - Primary ocular chondrosarcoma in a discus (Symphisodon aequifasciatus).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Zoo Wildl Med. 2013 Mar;44(1):225-31.

AUTORES / AUTHORS:  - Magi GE; Renzoni G; Piccionello AP; Rossi G

INSTITUCIÓN / INSTITUTION:  - School of Veterinary Medical Sciences, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica, Italy. gianenrico.magi@unicam.it

RESUMEN / SUMMARY:  - An adult discus (Symphisodon aequifasciatus) with a history of buphthalmia and anorexia was referred, from an aquarium, for clinical examination. Surgery was performed to enucleate the eye and obtain a definitive diagnosis. Macroscopic examination revealed a yellowish mass that affected the eye. Histologic examination of the mass revealed a poorly demarcated, high cellular infiltrative  mesenchymal neoplasm composed of ovoidal-spindloid cells with elongated nuclei and with scant cytoplasm arranged in a solid pattern. Throughout the tumor, there were scattered foci of cartilaginous differentiation that stained deeply with alcian blue and stained metachromatically with toluidine blue. The neoplastic cells were immunolabeled to varying degrees by antibodies against vimentin and SOX-9. Based on morphologic, histochemical, and immunohistochemical characteristics, the tumor was diagnosed as a chondrosarcoma.

 

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[657]

TÍTULO / TITLE:  - Surgical resection of a leiomyosarcoma of the inferior vena cava mimicking hepatic tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Med. 2013;2013:235698. doi: 10.1155/2013/235698. Epub 2013 Feb 20.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/235698

AUTORES / AUTHORS:  - Ueda J; Yoshida H; Mamada Y; Taniai N; Yoshioka M; Kawano Y; Mizuguchi Y; Shimizu T; Takata H; Uchida E

INSTITUCIÓN / INSTITUTION:  - Department of Gastrointestinal Hepatobiliary-Pancreatic Surgery, Nippon Medical School, Tokyo 113-8603, Japan.

RESUMEN / SUMMARY:  - Introduction. Leiomyosarcomas of vascular origin are particularly rare tumors occurring mainly in the inferior vena cava (IVC). They are malignant, slow-growing tumors with a poor prognosis. This paper reports on a rare case of surgical resection of an IVC leiomyosarcoma mimicking a hepatic tumor. Case Presentation. A 65-year-old Japanese male was admitted for evaluation of an abdominal tumor. Enhanced computed tomography of the abdomen revealed a slightly  enhanced heterogeneous tumor, 18 mm in diameter, between the Spiegel lobe of the  liver and the IVC in early-phase images, with no enhancement or washout in late-phase images. We diagnosed this tumor as either a hepatic tumor in the Spiegel lobe or a retroperitoneal tumor such as leiomyosarcoma or liposarcoma and performed a laparotomy. On the basis of surgical findings, we extirpated the tumor by performing a wedge resection of the wall of the IVC and suturing the primary IVC wall. Pathological findings led to a further diagnosis of the tumor as a leiomyosarcoma originating in the IVC. Thirty-seven months after the operation, multiple liver and lung metastases were detected, and the patient died from multiple organic failures. Conclusion. We experienced a rare case of a leiomyosarcoma of IVC mimicking hepatic tumor.

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[658]

TÍTULO / TITLE:  - Giant esophageal lipoma presenting with gastroesophageal reflux symptoms.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointestin Liver Dis. 2013 Mar;22(1):8.

AUTORES / AUTHORS:  - Yapali S; Oruc N; Harman M; Aydin A

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, Ege University, School of Medicine, Izmir, Turkey; Email:sunayapali@yahoo.com.

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[659]

TÍTULO / TITLE:  - Intradural lipoma: timely intervention is what matters.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Mar 14;2013. pii: bcr2013008820. doi: 10.1136/bcr-2013-008820.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-008820

AUTORES / AUTHORS:  - Kumar N; Kumar G; Dembla G; Trisal D

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, PGIMER & Dr Ram Manohar Lohia Hospital, New Delhi, India.

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[660]

TÍTULO / TITLE:  - Pediatric primitive intraneural synovial sarcoma of L-5 nerve root.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurosurg Pediatr. 2013 Apr;11(4):473-7. doi: 10.3171/2013.1.PEDS12181. Epub 2013 Feb 15.

            ●● Enlace al texto completo (gratuito o de pago) 3171/2013.1.PEDS12181

AUTORES / AUTHORS:  - Peia F; Gessi M; Collini P; Ferrari A; Erbetta A; Valentini LG

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery and.

RESUMEN / SUMMARY:  - Primitive intraneural synovial sarcomas are rare in children. The authors report  the case of a 7-year-old girl affected by intraneural synovial sarcoma of a lumbar nerve root, the first such lesion in this location described in a child. The lesion mimicked a schwannoma clinically and radiologically. There was long-lasting leg pain in a radicular distribution, and a well-demarcated intraneural tumor was seen on MRI. On this basis, the first resection was conservative. However, histological examination documented a classic biphasic synovial sarcoma, which was confirmed by immunohistochemistry. After radical resection and adjuvant treatment, complete disease control was achieved and verified at 5-year follow-up. This case strongly suggests that early diagnosis and a multidisciplinary approach to this unusual spinal lesion are essential to achieving a better prognosis.

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[661]

TÍTULO / TITLE:  - BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF  inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncotarget. 2013 Feb;4(2):310-5.

AUTORES / AUTHORS:  - Falchook GS; Trent JC; Heinrich MC; Beadling C; Patterson J; Bastida CC; Blackman SC; Kurzrock R

INSTITUCIÓN / INSTITUTION:  - Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

RESUMEN / SUMMARY:  - Activating oncogenic mutations of BRAF have been described in patients with gastrointestinal stromal tumor (GIST), but treatment of GIST with BRAF inhibitors and mechanisms of mediating the emergence of resistance in GIST have not been reported. Dabrafenib is a potent ATP-competitive inhibitor of BRAF kinase and is  highly selective for mutant BRAF in kinase panel screening, cell lines, and xenografts. We report prolonged antitumor activity in the first patient with V600E BRAF-mutated GIST who was treated with a BRAF inhibitor. Whole exome sequencing performed in tumor tissue obtained at the time of progressive disease  demonstrated a somatic gain-of-function PIK3CA mutation (H1047R) as well as a CDKN2A aberration, which may have contributed to eventual resistance to treatment.

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[662]

- CASTELLANO -

TÍTULO / TITLE:Hemoperitoneo secundario a GIST gastrico c-KIT negativo e anticorpo anti-DOG1 positivo.

TÍTULO / TITLE:  - Hemoperitoneum secondary to gastric GIST negative for c-KIT and positive for antibody anti-DOG1.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Einstein (Sao Paulo). 2012 Sep;10(3):377-379.

AUTORES / AUTHORS:  - Epstein MG; Pasquetti AF; Costa SV; Favaro MD; Contrucci Filho O; Ribeiro Junior MA

INSTITUCIÓN / INSTITUTION:  - Servico de Cirurgia Geral, Universidade de Santo Amaro, Sao Paulo, SP.

RESUMEN / SUMMARY:  - Although relatively rare, the gastrointestinal stromal tumors comprise most mesenchymal tumors of the digestive tract and account for 5% of all sarcomas. The most common symptoms are pain, gastrointestinal bleeding and palpable mass. This  study reported the case of a young patient who developed hemoperitoneum due to gastric neoplasm rupture and required urgent surgical treatment. Pathology and immunohistochemistry analysis showed an epidemiologically rare case: epithelioid  and c-KIT negative tumor.

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[663]

TÍTULO / TITLE:  - Metastatic chordoma detected by endobronchial ultrasound-guided transbronchial needle aspiration.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Thorac Dis. 2013 Feb;5(1):90-3. doi: 10.3978/j.issn.2072-1439.2012.12.01.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2072-1439.2012.12.01

AUTORES / AUTHORS:  - Fearon C; Fabre A; Heffernan EJ; Skehan SJ; Swan N; Keane MP; Butler MW

INSTITUCIÓN / INSTITUTION:  - Saint Vincent’s University Hospital, Education and Research Center, Elm Park, Dublin 4, Ireland;

RESUMEN / SUMMARY:  - Chordomas are rare, slow-growing malignant bone tumours arising from cellular remnants of the notochord. These tumours are locally invasive but have also a metastastic potential.Chordomas are characterized by the presence of physaliferous cells in a myxofibrillary stromal background. In cytological aspirates, these characteristic cells are usually absent, revealing only clusters of cells with varying degrees of vacuolation. This makes definitive diagnosis of  chordoma difficult as the tumor can mimic other myxoid neoplasms including renal  cell carcinomas and well-differentiated chondrosarcomas. In such situations, a confident diagnosis of chordoma requires comparison with histology of the primary tumor.We describe the first case of metastatic chordoma diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).

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[664]

TÍTULO / TITLE:  - Complex biological reconstruction after wide excision of osteogenic sarcoma in lower extremities.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Plast Surg Int. 2013;2013:538364. doi: 10.1155/2013/538364. Epub 2013 Jan 17.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/538364

AUTORES / AUTHORS:  - Abbas K; Umer M; Ur Rashid H

INSTITUCIÓN / INSTITUTION:  - Islam Medical College, Sialkot, Pakistan ; H No. 88 K-1, Wapda Town, Lahore, Pakistan.

RESUMEN / SUMMARY:  - Wide margin resection of extremity tumor sometimes leaves a huge soft tissue and  bony defects in limb salvage surgery. Adequate management of these defects is an  absolute requirement when aiming for functional limb. Multidisciplinary management in such cases is an answer when complex biologic reconstruction is desired. We aim to present cases of osteogenic sarcoma of lower extremity requiring combined surgical approach to achieve effective musculoskeletal reconstruction. Patients and Methods. From 2006 to 2010 ten patients were operated on for osteogenic sarcoma of lower extremity requiring complex musculoskeletal reconstruction. Results. Six patients had pathology around knee joint, whereas one each with mid tibia, mid femur, proximal femur, and heel bone. Locking compression plate was used in 7 patients including six with periarticular disease. Eight out of ten patients underwent biologic reconstruction using autograft; endoprosthetic reconstruction and hindquarter amputation were done in  the remaining two patients. Vascularized fibula was done in five patients, sural  artery flap which was primarily done in three patients, spare part fillet flap, free iliac crest flap, and Gastrocnemius flap was done in one patient each. Secondary hemorrhage, infection, nonunion, wound dehiscence, and flap failure were notable complications in four patients. The Average Musculoskeletal Tumor Society score was 89%. Conclusion. Combined surgical approach results in cosmetically acceptable and functional limb.

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[665]

TÍTULO / TITLE:  - Cellular microRNAs 498 and 320d regulate herpes simplex virus 1 induction of Kaposi’s sarcoma-associated herpesvirus lytic replication by targeting RTA.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(2):e55832. doi: 10.1371/journal.pone.0055832. Epub 2013 Feb 13.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0055832

AUTORES / AUTHORS:  - Yan Q; Li W; Tang Q; Yao S; Lv Z; Feng N; Ma X; Bai Z; Zeng Y; Qin D; Lu C

INSTITUCIÓN / INSTITUTION:  - State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People’s Republic of China.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma-associated herpesvirus (KSHV) infection was necessary but not sufficient for KS development without other cofactors. We have previously reported that herpes simplex virus (HSV)-1 was an important cofactor that reactivated KSHV from latency by inducing the expression of KSHV replication and  transcription activator (RTA), the lytic switch protein. Here, we further investigated the possible cellular microRNAs (miRNAs) involved in regulation of RTA during HSV-1-induced KSHV replication. The differential profiles of miRNAs expression between Mock- and HSV-1-infected body cavity-based lymphoma (BCBL-1) cells were identified by miRNA microarray analysis. Bioinformatics and luciferase reporter analyses showed that two of the HSV-1-downregulated cellular miRNAs, miR-498 and miR-320d, directly targeted the 3’ untranslated region (UTR) of KSHV  RTA. As a result, overexpression of these two miRNAs significantly inhibited HSV-1-induced KSHV replication, whereas repression of these miRNAs with specific  suppressors enhanced HSV-1-mediated KSHV replication. In addition, miR-498 or miR-320d alone, without HSV-1 infection, regulated KSHV replication in BCBL-1 cells. Finally, bioinformatics Gene Ontology (GO) analysis indicated that targets of HSV-1-regulated miRNAs were enriched for proteins, whose roles were involved in protein binding, enzyme activity, biological regulation, and several potential signaling pathways including transforming growth factor (TGF)-beta were likely to participate in HSV-1-induced KSHV replication. Collectively, these novel findings demonstrated that host-encoded miR-498 and miR-320d regulated HSV-1 induction of  KSHV lytic replication by targeting RTA, which provided further insights into the molecular mechanisms controlling KSHV lytic replication.

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[666]

TÍTULO / TITLE:  - Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Mar 8;11:59. doi: 10.1186/1477-7819-11-59.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-59

AUTORES / AUTHORS:  - Wicherts DA; van Coevorden F; Klomp HM; van Huizum MA; Kerst JM; Haas RL; van Boven HH; van der Hage J

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, Amsterdam, 1066CX, the Netherlands. j.vd.hage@nki.nl.

RESUMEN / SUMMARY:  - Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of  cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors.

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[667]

TÍTULO / TITLE:  - Recurrent phyllodes sarcoma of breast with complete chest wall invasion; a multidisciplinary approach for radical resection.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Feb 19;2013. pii: bcr2012008110. doi: 10.1136/bcr-2012-008110.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-008110

AUTORES / AUTHORS:  - Chaudhry IU; Asban A; Mahboub T; Arini A

INSTITUCIÓN / INSTITUTION:  - Department of Chest Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia. drihc@hotmail.com

RESUMEN / SUMMARY:  - Phyllodes tumour of the breast is a relatively uncommon condition, and rarely invades the chest wall. We report a case of young women who had recurrent large phyllodes tumour invading the chest wall, following mastectomy, chemotherapy and  radiotherapy. A multidisciplinary approach was used for radical resection of the  tumour, chest wall and reconstruction.

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[668]

TÍTULO / TITLE:  - Left ventricular apical papillary fibroelastoma resection via mediastinoscope through the aortic valve.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Innovations (Phila). 2012 Nov-Dec;7(6):452-3. doi: 10.1097/IMI.0b013e3182811be9.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IMI.0b013e3182811be9

AUTORES / AUTHORS:  - Toeg HD; Cusimano RJ

INSTITUCIÓN / INSTITUTION:  - Division of Cardiac Surgery, University of Ottawa Heart Institute, University of  Ottawa, Ottawa, Canada. htoeg@ottawaheart.ca

RESUMEN / SUMMARY:  - This case report describes a novel minimally invasive technique for complete resection of a cardiac papillary fibroelastoma by directly visualizing the mass via an intraoperative mediastinoscope placed through the aortic valve. A 68-year-old man presented to the emergency department with two episodes of transient ischemic attack. Echocardiography demonstrated a pedunculated, mobile mass in the left ventricular apex. Cardiac surgery was consulted, and complete resection of the fibroelastoma was carried out by inserting a mediastinoscope through the aortic valve and into the left ventricle, whereby the mass was directly visualized and excised with biopsy forceps. There were no postoperative  complications, and at 1-year follow-up, the patient had no further evidence of embolic events.

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[669]

TÍTULO / TITLE:  - Thoracoscopic resection and re-resection of an anterior chest wall chondrosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Innovations (Phila). 2012 Nov-Dec;7(6):445-7. doi: 10.1097/IMI.0b013e318284b12b.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IMI.0b013e318284b12b

AUTORES / AUTHORS:  - Hennon MW; Demmy TL

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. mark.hennon@roswellpark.org

RESUMEN / SUMMARY:  - The limits of thoracoscopic resections are expanding, with improved instruments for manipulating and dividing tissues such as the bone. We encountered a patient  with a primary chest wall tumor that had exposure characteristics similar to our  limited, but promising, experience with en bloc rib resections for primary lung cancer. A 71-year-old female patient presented with a symptomatic right meningocele, at which time a 7.7-cm left anterior mediastinal mass bulging through the second interspace was detected. With the patient in the lateral decubitus position, a modified three-incision approach similar to that for a video-assisted thorascopic surgery (VATS) lobectomy was performed but angled slightly different to expose the anterior chest wall. Using this approach, the mass was excised intact en bloc, with ribs 2 and 3 (9.5-cm total specimen with 6-cm longest rib). No chest wall reconstruction was necessary. The patient did well and had her chest tube removed on postoperative day (POD) 1, was discharged  with minimal pain on POD 3, and was pain free on POD 14. Because a microscopic focus of chondrosarcoma was found at the second rib intramedullary margin on the  final pathologic review, she returned for VATS re-resection of an additional 5 cm of rib on POD 43 using the same incisions, and her postoperative recovery was replicated. The operative times were 160 and 90 minutes, and blood loss was 400 and 100 mL, respectively. This case demonstrates that if traditional surgical values of exposure and oncologic safety can be replicated using enhanced instrumentation, it is reasonable to attempt more complex operations thoracoscopically. Even though ribs were removed, pain control was similar to other VATS operations.

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[670]

TÍTULO / TITLE:  - Endoscopic removal of a giant ethmoid osteoma with orbital extension.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Inform Med. 2012 Dec;20(4):266-8. doi: 10.5455/aim.2012.20.266-268.

            ●● Enlace al texto completo (gratuito o de pago) 5455/aim.2012.20.266-268

AUTORES / AUTHORS:  - Muderris T; Bercin S; Sevil E; Kiris M

INSTITUCIÓN / INSTITUTION:  - Ataturk Education and Research Hospital, Department of Otorhinolaryngology, Head  and Neck Surgery, Ankara, Turkey.

RESUMEN / SUMMARY:  - Osteomas are slow growing bony tumours of the paranasal sinuses. They are usually asymptomatic but they may present with headache, cerebral symptoms, or visual disturbances, depending on their anotomical location. A computerized tomography scan is the imaging modality that should be choosen for the diagnosis of osteomas. Radiographically, osteoid osteoma appears as an opaque lesion with a nidus which has a radioluscent center surrounded by dense sclerosis. If treatment is indicated, external or endoscopic approaches can be chosen. We report a rare case of giant ethmoido-orbital osteoma which was treated via endoscopic approach. The endoscopic way is convenient and safe enough with advantages over the external approach. The decreased morbidity and better cosmetic results are clear  advantages of this technique which has the potential to become the treatment of choice for selected ethmoid tumours, such as a giant tumour mentioned in this study.

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[671]

TÍTULO / TITLE:  - Assessing the contribution of HRPT2 to the pathogenesis of jaw fibrous dysplasia, ossifying fibroma, and osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar;115(3):359-67. doi: 10.1016/j.oooo.2012.11.015.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.oooo.2012.11.015

AUTORES / AUTHORS:  - de Mesquita Netto AC; Gomez RS; Diniz MG; Fonseca-Silva T; Campos K; De Marco L; Carlos R; Gomes CC

INSTITUCIÓN / INSTITUTION:  - Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

RESUMEN / SUMMARY:  - OBJECTIVE: To investigate HRPT2 in jaw ossifying fibroma (OF), fibrous dysplasia  (FD), and osteosarcoma (OS). STUDY DESIGN: We combined microsatellite loss of heterozygosity (LOH), HRPT2 sequence alterations at the mRNA level by reverse-transcription polymerase chain reaction (PCR), cDNA sequencing, and quantitative PCR (qPCR) and immunohistochemistry (IHC) in a total of 19 OF, 15 FD, and 9 OS. Because HRPT2 (parafibromin) interacts with cyclin D1, we investigated cyclin D1 expression with the use of qPCR and IHC. RESULTS: LOH was  detected in 3/5 FD, 6/9 OF, and 2/2 OS heterozygous samples. LOH was not associated with decreased mRNA levels or HRPT2 protein expression except for 1 OF which harbored an inactivating mutation. However, this tumor did not display altered transcription or protein levels of HRPT2 nor cyclin compared with the other OF. CONCLUSIONS: The contribution of HRPT2 inactivation to the pathogenesis of OF, FD, and OS is marginal at best and may be limited to progression rather than tumor initiation.

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[672]

TÍTULO / TITLE:  - A gasless laparoscopic technique of wide excision for gastric gastrointestinal stromal tumor versus open method.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Feb 25;11:44. doi: 10.1186/1477-7819-11-44.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-44

AUTORES / AUTHORS:  - Lee PC; Lai PS; Yang CY; Chen CN; Lai IR; Lin MT

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, National Taiwan University Hospital, No,7 Chung-Shan South Road, Taipei 100, Taiwan. d97421103@ntu.edu.tw.

RESUMEN / SUMMARY:  - BACKGROUND: Traditional open surgery for gastrointestinal stromal tumors (GIST) requires a long incision. Moreover, the gas-filling laparoscopic technique used in GIST surgery still has its limitations. Therefore, we developed a gasless laparoscopic (GL) surgery for GIST and compared it with traditional open surgery. METHODS: Between October 2007 and September 2009, 62 GIST patients in the National Taiwan University Hospital received wide excisions. Of these 62 patients, 30 underwent the new procedure (GL group) and 32 had open surgery (OS group). Preoperative and postoperative clinicopathologic characteristics were compared between the groups. RESULTS: There were no significant differences in preoperative characteristics or blood loss. However, the days to first flatus, postoperative hospital stay, wound length, white blood cell count at postoperative day one, and peak daily body temperature were all significantly improved in the GL group. Usage of postoperative analgesia on postoperative days  one to five was also significantly lower in the GL group. CONCLUSIONS: Wide-excision laparoscopy for gastric GIST can be performed more safely, more effectively, and with faster postoperative recovery using the gasless technique as compared with the open method. We, therefore, recommend this new surgical technique, which hybridizes the advantages of both the traditional open method and pure laparoscopic surgery.

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[673]

TÍTULO / TITLE:  - Uterine angioleiomyoma: unusual appearance at laparoscopy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Minim Invasive Gynecol. 2013 Mar;20(2):149-50. doi: 10.1016/j.jmig.2012.08.777.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jmig.2012.08.777

AUTORES / AUTHORS:  - Jin CH; Yi KW; Kim YS; Shin JH; Kim T; Hur JY; Kim SH

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Eulji University Hospital, Daejeon, Korea.

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[674]

TÍTULO / TITLE:  - Plantar fibromatosis may adopt the brain gyriform pattern of a low-grade fibromyxoid sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Foot (Edinb). 2013 Feb 14. pii: S0958-2592(12)00138-1. doi: 10.1016/j.foot.2012.12.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.foot.2012.12.006

AUTORES / AUTHORS:  - Touraine S; Bousson V; Kaci R; Parlier-Cuau C; Haddad S; Laouisset L; Petrover D; Laredo JD

INSTITUCIÓN / INSTITUTION:  - Radiologie Osteo-Articulaire, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France. Electronic address: sebastien.touraine@lrb.aphp.fr.

RESUMEN / SUMMARY:  - We report the case of a 42-year-old man with histologically proven plantar fibromatosis (Ledderhose disease) demonstrating an uncommon brain gyriform pattern at MRI, so far exclusively described in the low-grade fibromyxoid sarcoma (LGFMS). An acoustic posterior enhancement at ultrasound, a high intensity on T2w and post-contrast T1wMR images were unusual and related to a high tumor cellularity at histology with no myxoid tissue. The juxtaposition of areas of high and low cellularity (with more fibrous material) in a multilobulated mass built a brain gyriform pattern at MR, similar to what was so far described exclusively in LGFMS. This case demonstrates that the brain gyriform pattern may  also be observed in other soft tissue fibrous tumors with no myxoid material but  with high cellularity areas alternating with fibrous zones of low cellularity.

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[675]

TÍTULO / TITLE:  - Localized Ewing sarcoma of the tibia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Sarcoma Res. 2013 Feb 4;3(1):2. doi: 10.1186/2045-3329-3-2.

            ●● Enlace al texto completo (gratuito o de pago) 1186/2045-3329-3-2

AUTORES / AUTHORS:  - Kashima TG; Gamage NG; Dirksen U; Gibbons CL; Ostlere SJ; Athanasou NA

INSTITUCIÓN / INSTITUTION:  - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford OX7HE, UK. nick.athanasou@ndorms.ox.ac.uk.

RESUMEN / SUMMARY:  - Ewing sarcoma (ES) is a high-grade malignant primary round cell tumour of bone in which there is commonly extension into extraosseous soft tissues at the time of diagnosis. This report details the clinical, radiological and pathological features of a case of ES of the tibia in which there was extensive osseous involvement but no infiltration beyond the periosteum into surrounding soft tissue. We also record the findings of one other ES case that exhibited similar behaviour. Both cases were male, involved the tibia and had the characteristic t  (11;22) (q24;q12) translocation. No recurrence of tumour or metastasis has been seen in these two cases, both of which have had 6 years follow-up. Our findings indicate that there is heterogeneity in the behaviour of ES and show that localized ES is associated with a good prognosis.

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[676]

TÍTULO / TITLE:  - Infiltrative laryngeal lipoma in a Yorkshire Terrier as cause of severe dyspnoea.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tierarztl Prax Ausg K Kleintiere Heimtiere. 2013;41(1):53-6.

AUTORES / AUTHORS:  - Brunnberg M; Cinquoncie S; Burger M; Plog S; Nakladal B

INSTITUCIÓN / INSTITUTION:  - Small Animal Clinic, Faculty of Veterinary Medicine, Freie Universitat Berlin, Germany. mathias.brunnberg@fu-berlin.de

RESUMEN / SUMMARY:  - A 10-year-old Yorkshire Terrier with suspected laryngeal paralysis was referred for further examination and surgical treatment. The dog displayed severe dyspnoea and dysphonia. Ventrolateral to the larynx a soft-elastic mass of 2 cm diameter was palpated and confirmed by radiography. Histopathological examination of the resected mass revealed an infiltrative lipoma/lipoma. Although the dog totally recovered after surgery, the prognosis remains guarded due to the high risk of a  recurrence. Tumours of the larynx in general and an infiltrative lipoma specifically should be added to the list of differential diagnosis in dogs presented with clinical signs that could be misinterpreted as laryngeal paralysis.

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[677]

TÍTULO / TITLE:  - Unusual Concentration of Tc-99m methylendiphosphonate in Rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Radiol Case Rep. 2012 Sep;6(9):29-34. doi: 10.3941/jrcr.v6i9.1144. Epub 2012 Sep 1.

            ●● Enlace al texto completo (gratuito o de pago) 3941/jrcr.v6i9.1144

AUTORES / AUTHORS:  - Franco A; Henderson PR; McDonough CH

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Georgia Health Sciences University, Augusta, GA 30912, USA. afranco@georgiahealth.edu

RESUMEN / SUMMARY:  - Extraosseous accumulation of bone-seeking agents is rare, but has been previously reported in pediatric sarcomas and neuroblastomas. We present an unusual case of  a 5-month-old male with an abdominal mass observed clinically by his parents and  referring pediatrician. Contrast abdominal computerized tomography confirmed the  presence of a large pelvic mass that was diagnosed pathologically as embryonal rhabdomyosarcoma. A bone scintigraphy that was performed for staging of the disease revealed accumulation of the radiopharmaceutical in the tumor. There was  no evidence for skeletal metastatic disease. This case further demonstrates the nonspecificity of soft-tissue tumor uptake on bone scintigraphy.

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[678]

TÍTULO / TITLE:  - Extra-skeletal Osteosarcoma Presenting as a Peri-ampullary Mass.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Cancer. 2013 Mar 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12029-013-9488-4

AUTORES / AUTHORS:  - Khalaf A; Heller MT

INSTITUCIÓN / INSTITUTION:  - University of Pittsburgh School of Medicine, Office of Medical Education, 3550 Terrace St, M211 Scaife Hall, Pittsburgh, PA, 15261, USA.

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[679]

TÍTULO / TITLE:  - CITRATE-CAPPED SILVER NANOPARTICLES SHOW GOOD BACTERICIDAL EFFECT AGAINST BOTH PLANKTONIC AND SESSILE BACTERIA AND A LOW CYTOTOXICITY TO OSTEOBLASTIC CELLS.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - ACS Appl Mater Interfaces. 2013 Mar 27.

            ●● Enlace al texto completo (gratuito o de pago) 1021/am400044e

AUTORES / AUTHORS:  - Flores CY; Minan AG; Grillo CA; Salvarezza RC; Vericat C; Schilardi PL

RESUMEN / SUMMARY:  - A common problem with implants is that bacteria can form biofilms on their surfaces which can lead to infection and, eventually, to implant rejection. An interesting strategy to inhibit bacterial colonization is the immobilization of silver species on the surface of the devices. The aim of this paper is to investigate the action of citrate-capped silver nanoparticles (AgNPs) on clinically relevant Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria in two different situations: (i) dispersed AgNPs (to assess the effect against planktonic bacteria) and (ii) adsorbed AgNPs  on titanium (Ti) substrates, a material widely used for implants (to test their effect against sessile bacteria). In both cases the number of surviving cells was quantified. The small amount of silver on the surface of Ti has an antimicrobial  effect similar to that of pure silver surfaces. We have also investigated the capability of AgNPs to kill planktonic bacteria and their cytotoxic effect on UMR-106 osteoblastic cells. The minimum bactericidal concentration (MBC) found for both strains is much lower than the AgNP concentration that results cytotoxic to osteoblasts. Planktonic P. aeruginosa show a higher susceptibility to silver than S. aureus, which can be caused by the different wall structure, while for sessile bacteria, similar results are obtained for both strains. This result can  be explained by the presence of extracellular polymeric substances (EPS) in the early stages of P. aeruginosa biofilm formation. Our findings can be important to improve the performance of Ti-based implants, as a good bactericidal action is obtained with very small quantities of silver which do not result detrimental to  the cells involved in the osseointegration process.

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[680]

TÍTULO / TITLE:  - Bronchial carcinosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Radiol Case Rep. 2012 Oct;6(10):26-31. doi: 10.3941/jrcr.v6i10.1049. Epub 2012  Oct 1.

            ●● Enlace al texto completo (gratuito o de pago) 3941/jrcr.v6i10.1049

AUTORES / AUTHORS:  - Carcano C; Savage E; Diacovo MJ; Kirsch J

INSTITUCIÓN / INSTITUTION:  - Division of Radiology, Cleveland Clinic Florida, Weston, FL, USA. carcanc@ccf.org

RESUMEN / SUMMARY:  - Carcinosarcoma is an uncommon mixed tumor of the lung. We present the case of a 65 year-old-male with cough and a right lower lobe radio-opacity who underwent resection, showing a large endobronchial tumor with an epithelial component of non-small cell carcinoma and malignant mesenchymal elements. The radiologic and histopathologic features are reviewed with reference to relevant literature.

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[681]

TÍTULO / TITLE:  - Management of gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Future Oncol. 2013 Feb;9(2):193-206. doi: 10.2217/fon.12.178.

            ●● Enlace al texto completo (gratuito o de pago) 2217/fon.12.178

AUTORES / AUTHORS:  - Rajendra R; Pollack SM; Jones RL

INSTITUCIÓN / INSTITUTION:  - University of Washington/Fred Hutchinson Cancer Research Center, 825 Eastlake Avenue E., G3630, Seattle, WA 98109-1023, USA.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs) comprise <1% of all gastrointestinal tumors, but are the most common mesenchymal tumors of the GI tract. This review highlights the dramatic changes in clinical practice with regards to GIST in the  last decade, with a focus on overall management and recent developments. For localized primary GISTs, surgical resection is the mainstay of therapy with the 5-year survival rate after complete resection averaging approximately 50-65%. Factors such as tumor size, mitotic rate, tumor location, kinase mutational status and occurrence of tumor rupture have been extensively studied and proposed to be predictors of outcome. Adjuvant imatinib is proposed as an option for those patients with a substantial risk of relapse. Unresectable metastatic or recurrent GIST can be treated with imatinib, with a remarkable response rate (50-70%) and prolonged survival (median progression-free survival: 18-20 months; median overall survival: 51-57 months). Sunitinib is licensed as a second-line therapy following progression on imatinib. Other promising systemic therapies include regorafenib and agents targeting the PI3K/mTOR pathway.

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[682]

TÍTULO / TITLE:  - Soft tissue tumors of the anorectum: rare, complex and misunderstood.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Oncol. 2013 Mar;4(1):82-94. doi: 10.3978/j.issn.2078-6891.2012.042.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2078-6891.2012.042

AUTORES / AUTHORS:  - Nassif MO; Trabulsi NH; Bullard Dunn KM; Nahal A; Meguerditchian AN

INSTITUCIÓN / INSTITUTION:  - Division of Experimental Surgery, McGill University, 845 Sherbrooke Street West Montreal, Quebec, Canada H3A 2T5; ; Department of Surgery, King Abdulaziz University, P.O. Box 80205, Zip Code 21589, Jeddah, Saudi Arabia;

RESUMEN / SUMMARY:  - Anorectal soft tissue tumors are uncommon and often present both diagnostic and therapeutic challenges. Although many of these tumors are identified with imaging performed for unrelated reasons, most present with nonspecific symptoms that can  lead to a delay in diagnosis. Historically, radical surgery (abdominoperineal resection) has been the mainstay of treatment for both benign and malignant anorectal soft tissue tumors. However, a lack of proven benefit in benign disease along with changes in technology has called this practice into question. In addition, the role of radiation and/or chemotherapy remains controversial. In this manuscript, we review the history and current status of anorectal soft tissue tumor management, with a particular focus on challenges in optimizing survival.

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[683]

TÍTULO / TITLE:  - Letter to the Editor: Chordoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurosurg Spine. 2013 Feb 15.

            ●● Enlace al texto completo (gratuito o de pago) 3171/2012.2.SPINE111060

AUTORES / AUTHORS:  - Hueng DY; Ma HI; Sytwu HK

INSTITUCIÓN / INSTITUTION:  - Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

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[684]

TÍTULO / TITLE:  - Low-Grade Uterine Epithelioid Hemangioendothelioma Presented as a Submucosal Leiomyoma during Labor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Pathol. 2013;2013:423584. doi: 10.1155/2013/423584. Epub 2013 Jan 20.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/423584

AUTORES / AUTHORS:  - Koutsopoulos AV; Sivridis E; Tsikouras P; Liberis V; Karpathiou G; Giatromanolaki A

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Faculty of Medicine, Democritus University of Thrace and University General Hospital of Alexandroupolis, Thrace, 68100 Alexandroupolis, Greece.

RESUMEN / SUMMARY:  - With the exception of leiomyomas, soft tissue tumors of the uterine corpus are not common. This is particularly true for vascular neoplasms, with the epithelioid hemangioendothelioma being a curiosity; not more than twenty-two cases of malignant hemangioendotheliomas have been reported in the literature so  far, all of which were high-grade hemangioendotheliomas (hemangiosarcomas). We present herewith a unique case of low-grade epithelioid hemangioendothelioma of the uterus in a pregnant woman aged 29 years. The clinical, histological, and immunohistochemical characteristics of this entity, together with its differential diagnosis, are discussed.

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[685]

TÍTULO / TITLE:  - Soft tissue chondroma of hard palate associated with cleft palate.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Plast Surg. 2012 Sep;45(3):550-2. doi: 10.4103/0970-0358.105974.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0970-0358.105974

AUTORES / AUTHORS:  - Nehete R; Nehete A; Singla S; Sankalecha S

INSTITUCIÓN / INSTITUTION:  - Vedant (Nehete) Hospital, Nashik, Maharashtra, India.

RESUMEN / SUMMARY:  - Soft tissue chondroma of palate is very rare. It has never been reported in a cleft palate patient. We report a case of 22-year-old male who came with asymptomatic swelling on the palate since birth, along with complete cleft of secondary palate. He had symptoms related to cleft palate only, i.e., nasal regurgitation and speech abnormalities. Swelling was excised and the cleft palate was repaired. Histopathological examination revealed chondroma of the palate. The patient had no recurrence after 2 years of follow-up.

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[686]

TÍTULO / TITLE:  - Inflammatory myofibroblastic tumor of the lung and the maxillary region: a benign lesion with aggressive behavior.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Dent. 2013;2013:879792. doi: 10.1155/2013/879792. Epub 2013 Mar 6.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/879792

AUTORES / AUTHORS:  - Gallego L; Santamarta TR; Blanco V; Garcia-Consuegra L; Cutilli T; Junquera L

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, Cabuenes Hospital, 33394 Gijon, España.

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumor (IMT) is a rare mass-forming lesion characterized by fibroblastic or myofibroblastic spindle cell proliferation with  varying degrees of inflammatory cell infiltration. Although it has been reported  in virtually every organ in the body, the lung is the most common site of involvement. Extrapulmonary IMTs, although rare, have been reported and are characterized by different, more aggressive behavior. We report an extremely rare case of maxillary metastases of pulmonary IMT. Lung IMT was initially misdiagnosed, and oral lesion mimicked clinically and radiologically a radicular  cyst. On histologic examination, cells exhibited diffuse and intense immunoreactivity for alpha -smooth muscle actin and vimentin whereas both pulmonary and oral IMTs presented absence of cellular atypia and lack of expressivity of oncogenic determinants. Distant metastases of lung IMT are extremely unusual, and this is the first report to our knowledge with this particular clinical course. Despite the possibility that the present case could also represent a metachronous multifocal IMT, with pulmonary and extrapulmonary lesions, similar histopathological and immunohistochemical patterns in lung and maxillary region suggest a metastatic course.

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[687]

TÍTULO / TITLE:  - Large gastric lipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Kathmandu Univ Med J (KUMJ). 2012 Jul;10(39):70-2.

AUTORES / AUTHORS:  - Sharma BK; Dhakal OP

INSTITUCIÓN / INSTITUTION:  - Department Of Radiodiagnosis, Sikkim Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital (CRH), Sikkim, India.

RESUMEN / SUMMARY:  - Gastric lipoma is a rare benign tumor and seen in five percent of gastro-intestinal lipomas and accounts for less than one percent of all gastric tumors. Gastric lipomas are located submucosally and usually in antral region of  Stomach. Computed tomography is considered as valuable tool in the diagnosis of gastrointestinal lipomas. Due to their relative rarity, gastric lipomas are often left out of the differential diagnosis for upper gastro-intestinal submucosal masses. We report a case of 70 year female that presented with upper abdominal pain since last two years. Abdominal Computed tomography revealed a large gastric lipoma in antral region. Patient refused for any surgical intervention due to old age. Patient was provided symptomatic treatment and was under regular followup.

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[688]

TÍTULO / TITLE:  - Microsatellite instability in sarcoma: fact or fiction?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - ISRN Oncol. 2012;2012:473146. doi: 10.5402/2012/473146. Epub 2012 Jul 18.

            ●● Enlace al texto completo (gratuito o de pago) 5402/2012/473146

AUTORES / AUTHORS:  - Monument MJ; Lessnick SL; Schiffman JD; Randall RT

INSTITUCIÓN / INSTITUTION:  - Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.

RESUMEN / SUMMARY:  - Microsatellite instability (MSI) is a unique molecular abnormality, indicative of a deficient DNA mismatch repair (MMR) system. Described and characterized in the  colorectal cancer literature, the MSI-positive phenotype is predictive of disease susceptibility, pathogenesis, and prognosis. The clinical relevance of MSI in colorectal cancer has inspired similar inquisition within the sarcoma literature, although unfortunately, with very heterogeneous results. Evolving detection techniques, ill-defined sarcoma-specific microsatellite loci and small study numbers have hampered succinct conclusions. The literature does suggest that MSI  in sarcoma is observed at a frequency similar to that of sporadic colorectal cancers, although there is little evidence to suggest that MSI-positive tumors share distinct biological attributes. Emerging evidence in Ewing sarcoma has demonstrated an intriguing mechanistic role of microsatellite DNA in the activation of key EWS/FLI-target genes. These findings provide an alternative perspective to the biological implications of microsatellite instability in sarcoma and warrant further investigation using sophisticated detection techniques, sensitive microsatellite loci, and appropriately powered study designs.

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[689]

TÍTULO / TITLE:  - Triggering of the finger at the wrist due to a leiomyoma arising from the lumbrical muscle of the middle finger.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Hand Surg Eur Vol. 2013 Feb 6.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1753193413475583

AUTORES / AUTHORS:  - Karaarslan AA; Ozturk AM; Sesli E

INSTITUCIÓN / INSTITUTION:  - Sifa University Hospital Department of Orthopaedic Surger, Ege University Hospital Department of Orthopaedic Surgery, Izmir, Turkey.

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[690]

TÍTULO / TITLE:  - Leiomyoma of the forehead.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Plast Surg. 2013 Mar;40(2):165-7. doi: 10.5999/aps.2013.40.2.165. Epub 2013  Mar 11.

            ●● Enlace al texto completo (gratuito o de pago) 5999/aps.2013.40.2.165

AUTORES / AUTHORS:  - Kwon JH; Lim SY; Lim HS

INSTITUCIÓN / INSTITUTION:  - Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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[691]

TÍTULO / TITLE:  - Effect of Thermal Stress on MICA/B Induction in a Human Liposarcoma Cell Line.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Iran J Immunol. 2013 Mar;10(1):31-9. doi: IJIv10i1A4.

AUTORES / AUTHORS:  - Farjadian S; Rahimifar S; Erfani N; Lotfi R

INSTITUCIÓN / INSTITUTION:  - Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran, farjadsh@sums.ac.ir.

RESUMEN / SUMMARY:  - Background: A possible mechanism by which hyperthermia enhances tumor immunogenicity is the induction of NKG2D ligands on tumor cells. Although the expression of MHC class I chain-related protein A and B (MICA/B) has previously been reported in different carcinomas, there is no information about MICA/B expression in liposarcomas. Objective: To investigate MICA/B induction in a human liposarcoma cell line (SW-872) after thermotherapy. Methods: SW-872 and HeLa cell lines were subjected to thermal stress for 1 h at 42, 44 and 46C, and after 2, 4  and 6 h of incubation at 37C, MICA/B expression was assessed at the mRNA and protein levels. Results: Despite high levels of MICA/B transcripts in SW-872 cells at baseline, the expression of these genes decreased significantly at both  the mRNA and protein levels after almost all thermal treatments. Conclusion: Our  data conclude that thermotherapy under 42-46 C had no effect on MICA/B induction  on SW-872 liposarcoma cell line but the effects of fever-range temperatures remain to be tested on this cell line.

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[692]

TÍTULO / TITLE:  - Fibrous Dysplasia and Fibroblast Growth Factor-23 Regulation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Curr Osteoporos Rep. 2013 Mar 27.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11914-013-0144-5

AUTORES / AUTHORS:  - Boyce AM; Bhattacharyya N; Collins MT

INSTITUCIÓN / INSTITUTION:  - Bone Health Program, Division of Orthopaedics and Sports Medicine, Children’s National Medical Center, 111 Michigan Ave NW, Washington, DC, 20010, USA, aboyce@childrensnational.org.

RESUMEN / SUMMARY:  - Fibrous dysplasia (FD) is a skeletal disorder caused by activating mutations in Gsalpha that result in elevations in cAMP. A feature of FD is elevated blood levels of the bone cell-derived phosphaturic hormone, fibroblast growth factor-23 (FGF23). FGF23 regulates serum phosphorus and active vitamin D levels by action on proximal renal tubule cells. An essential step in the production of biologically active FGF23 is glycosylation by the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl transferase (ppGalNAc-T3). In the absence of glycosylation, FGF23 is processed into inactive  N- and C-terminal proteins by a subtilisin proprotein convertase, probably furin. Normally, most if not all circulating FGF23 is intact. In FD, C-terminal levels are elevated, suggesting altered FGF23 processing. Altered processing in FD is the result of a cAMP-dependent, coordinated decrease in ppGalNAc-T3 and an increase in furin enzyme activity. These findings, and emerging data from other diseases, suggest regulation of FGF23 processing may be a physiologically important process.

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[693]

TÍTULO / TITLE:  - Robotic-assisted enucleation of a large lower esophageal leiomyoma and review of  literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Med Robot. 2013 Feb 12. doi: 10.1002/rcs.1484.

            ●● Enlace al texto completo (gratuito o de pago) 1002/rcs.1484

AUTORES / AUTHORS:  - Khalaileh A; Savetsky I; Adileh M; Elazary R; Abu-Gazala M; Gazala SA; Schlager A; Rivkind A; Mintz Y

INSTITUCIÓN / INSTITUTION:  - Hadassah Hebrew University Medical Center, General - Surgery, PO Box 12000, Jerusalem, 91120, Israel.

RESUMEN / SUMMARY:  - Leiomyoma is the most common benign esophageal neoplasm. Different invasive surgical approaches have been described for management of such lesions. The literature is reviewed and a robotic assisted left thoracoscopic enucleation with the patient in the right side position is described. A 40-year-old male patient,  otherwise healthy, found to have a lower midiastinal mass on screening X-ray, is  described. Physical examination and blood tests were within normal limits. Diagnostic work-up included: computerized tomography (CT) scanning of the chest and midiastinum that revealed a 40 x 30 mm mass of the distal esophagus, an upper gastrointestinal endoscopy showed a lower protruding esophageal submucosal mass with intact mucosa, a filling defect was apparent on esophagography. Endoscopic ultrasonography (EUS) showed the same findings, biopsies were taken and leimyoma  was diagnosed. Under general anesthesia with a double-lumen endotracheal tube, the patient was positioned on his right side. A 30 robotic scope was introduced in the left 7th intercostal space on the posterior axillary line. Two 8-mm robotic trocars were inserted in the left 5th and 9th intercostals spaces on the  same line. Operative field was clearly exposed and an additional 5-mm ethicon trocar was inserted. The inferior pulmonary ligament was released, the parietal pleural space opened, proximal and distal control was achieved using Penrose. The muscular layer of the lower esophagus was opened by coagulation hook, the lesion  was enucleated without mucosal penetration. Intraoperative endoscopy permitted localization of the lesion and ensured mucosal integrity. The muscular layer was  not closed and the chest drain was left. Total operative time was 200 min and blood loss was less than 20 mL. A Gastrograffin swallow on the first post-operative day showed good esophageal clearance and absence of leak, the patient was allowed a liquid diet. He was discharged on the third post-operative  day in a good general condition, benign pathology was confirmed. Copyright © 2013 John Wiley & Sons, Ltd.

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[694]

TÍTULO / TITLE:  - Epigenetic Deregulation of MicroRNAs in Rhabdomyosarcoma and Neuroblastoma and Translational Perspectives.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Mol Sci. 2012 Dec 5;13(12):16554-79. doi: 10.3390/ijms131216554.

            ●● Enlace al texto completo (gratuito o de pago) 3390/ijms131216554

AUTORES / AUTHORS:  - Romania P; Bertaina A; Bracaglia G; Locatelli F; Fruci D; Rota R

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Hematology-Oncology, Ospedale Pediatrico Bambino Gesu, IRCCS, Piazza S. Onofrio 4, Roma 00165, Italy. doriana.fruci@opbg.net.

RESUMEN / SUMMARY:  - Gene expression control mediated by microRNAs and epigenetic remodeling of chromatin are interconnected processes often involved in feedback regulatory loops, which strictly guide proper tissue differentiation during embryonal development. Altered expression of microRNAs is one of the mechanisms leading to  pathologic conditions, such as cancer. Several lines of evidence pointed to epigenetic alterations as responsible for aberrant microRNA expression in human cancers. Rhabdomyosarcoma and neuroblastoma are pediatric cancers derived from cells presenting features of skeletal muscle and neuronal precursors, respectively, blocked at different stages of differentiation. Consistently, tumor cells express tissue markers of origin but are unable to terminally differentiate. Several microRNAs playing a key role during tissue differentiation are often epigenetically downregulated in rhabdomyosarcoma and neuroblastoma and  behave as tumor suppressors when re-expressed. Recently, inhibition of epigenetic modulators in adult tumors has provided encouraging results causing re-expression of anti-tumor master gene pathways. Thus, a similar approach could be used to correct the aberrant epigenetic regulation of microRNAs in rhabdomyosarcoma and neuroblastoma. The present review highlights the current insights on epigenetically deregulated microRNAs in rhabdomyosarcoma and neuroblastoma and their role in tumorigenesis and developmental pathways. The translational clinical implications and challenges regarding modulation of epigenetic chromatin remodeling/microRNAs interconnections are also discussed.

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[695]

TÍTULO / TITLE:  - Primary Ewing sarcoma of the anterior mandible localized to the midline.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan 31. pii: S2212-4403(12)01718-X. doi: 10.1016/j.oooo.2012.11.010.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.oooo.2012.11.010

AUTORES / AUTHORS:  - Ko E; Brouns ER; Korones DN; Pochal WF; Philipone EM; Zegarelli DJ; Yoon AJ

INSTITUCIÓN / INSTITUTION:  - Division of Oral and Maxillofacial Pathology, Columbia University, College of Dental Medicine, New York, NY.

RESUMEN / SUMMARY:  - Ewing sarcoma is a malignant, small, round blue-cell tumor of the bone that is usually located in the long bones and the pelvis. Fewer than 3% of all Ewing sarcomas originate in the head and neck region and these are mostly located in the posterior mandible. We report the case of a 17-year-old girl with a primary Ewing sarcoma localized at the midline of the anterior mandible.

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[696]

TÍTULO / TITLE:  - Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(3):e57523. doi: 10.1371/journal.pone.0057523. Epub 2013 Mar 8.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0057523

AUTORES / AUTHORS:  - Kreahling JM; Foroutan P; Reed D; Martinez G; Razabdouski T; Bui MM; Raghavan M; Letson D; Gillies RJ; Altiok S

INSTITUCIÓN / INSTITUTION:  - Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America.

RESUMEN / SUMMARY:  - Sarcomas are rare and heterogeneous mesenchymal tumors affecting both pediatric and adult populations with more than 70 recognized histologies. Doxorubicin and ifosfamide have been the main course of therapy for treatment of sarcomas; however, the response rate to these therapies is about 10-20% in metastatic setting. Toxicity with the drug combination is high, response rates remain low, and improvement in overall survival, especially in the metastatic disease, remains negligible and new agents are needed. Wee1 is a critical component of the G2/M cell cycle checkpoint control and mediates cell cycle arrest by regulating the phosphorylation of CDC2. Inhibition of Wee1 by MK1775 has been reported to enhance the cytotoxic effect of DNA damaging agents in different types of carcinomas. In this study we investigated the therapeutic efficacy of MK1775 in various sarcoma cell lines, patient-derived tumor explants ex vivo and in vivo both alone and in combination with gemcitabine, which is frequently used in the treatment of sarcomas. Our data demonstrate that MK1775 treatment as a single agent at clinically relevant concentrations leads to unscheduled entry into mitosis and initiation of apoptotic cell death in all sarcomas tested. Additionally, MK1775 significantly enhances the cytotoxic effect of gemcitabine in sarcoma cells lines with different p53 mutational status. In patient-derived bone and soft tissue sarcoma samples we showed that MK1775 alone and in combination with gemcitabine causes significant apoptotic cell death. Magnetic resonance imaging (MRI) and histopathologic studies showed that MK1775 induces significant cell death and terminal differentiation in a patient-derived xenograft mouse model of osteosarcoma in vivo. Our results together with the high safety profile of MK1775 strongly suggest that this drug can be used as a potential therapeutic agent in the treatment of both adult as well as pediatric sarcoma patients.

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[697]

TÍTULO / TITLE:  - Large hepatic angiomyolipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Res Hepatol Gastroenterol. 2013 Feb 20. pii: S2210-7401(13)00031-4. doi: 10.1016/j.clinre.2013.01.004.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinre.2013.01.004

AUTORES / AUTHORS:  - Qi X; Yan H; Han G; Wu K; Fan D

INSTITUCIÓN / INSTITUTION:  - Department of Digestive Interventional Radiology, Xijing Hospital of Digestive Diseases, Xi’an, China.

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[698]

TÍTULO / TITLE:  - BCL11B Is Up-Regulated by EWS/FLI and Contributes to the Transformed Phenotype in Ewing Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(3):e59369. doi: 10.1371/journal.pone.0059369. Epub 2013 Mar 19.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0059369

AUTORES / AUTHORS:  - Wiles ET; Lui-Sargent B; Bell R; Lessnick SL

INSTITUCIÓN / INSTITUTION:  - Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America.

RESUMEN / SUMMARY:  - The EWS/FLI translocation product is the causative oncogene in Ewing sarcoma and  acts as an aberrant transcription factor. EWS/FLI dysregulates gene expression during tumorigenesis by abnormally activating or repressing genes. The expression levels of thousands of genes are affected in Ewing sarcoma, however, it is unknown which of these genes contribute to the transformed phenotype. Here we characterize BCL11B as an up-regulated EWS/FLI target that is necessary for the maintenance of transformation in patient derived Ewing sarcoma cells lines. BCL11B, a zinc finger transcription factor, acts as a transcriptional repressor in Ewing’s sarcoma and contributes to the EWS/FLI repressed gene signature. BCL11B repressive activity is mediated by the NuRD co-repressor complex. We further demonstrate that re-expression of SPRY1, a repressed target of BCL11B, limits the transformation capacity of Ewing sarcoma cells. These data define a new pathway downstream of EWS/FLI required for oncogenic maintenance in Ewing sarcoma.

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[699]

TÍTULO / TITLE:  - Successful removal of endobronchial lipoma by flexible bronchoscopy using electrosurgical snare.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tuberc Respir Dis (Seoul). 2013 Feb;74(2):82-5. doi: 10.4046/trd.2013.74.2.82. Epub 2013 Feb 28.

            ●● Enlace al texto completo (gratuito o de pago) 4046/trd.2013.74.2.82

AUTORES / AUTHORS:  - Yun SC; Na MJ; Choi E; Kwon SJ; Lee SJ; Oh SH; Cha EJ; Son JW

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, Konyang University Hospital, Konyang University  College of Medicine, Daejeon, Korea.

RESUMEN / SUMMARY:  - A 62-year-old man with a chronic cough presented with atelectasis of the left upper lobe on chest X-ray. Chest computed tomography showed an atelectasis in the left upper lobe with bronchial wall thickening, stenosis, dilatation, and mucoid  impaction. We performed bronchoscopy and found a well-circumscribed mass on the left upper lobe bronchus. The mass was removed by flexible bronchoscopy using an  electrosurgical snare and diagnosed with lipoma. An endobronchial lipoma is a rare benign tumor that can be treated by a surgical or endoscopic approach. We report the successful removal of endobronchial lipoma via flexible bronchoscopic  electrosurgical snare.

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[700]

TÍTULO / TITLE:  - Two-stage, combined, three-level en bloc spondylectomy for a recurrent post-radiation sarcoma of the lumbar spine.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Orthop Surg Traumatol. 2013 Jan 13.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00590-012-1160-3

AUTORES / AUTHORS:  - Casadei R; Mavrogenis AF; De Paolis M; Ruggieri P

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Pupilli, 1, 40136, Bologna, BO, Italy, roberto.casadei@ior.it.

RESUMEN / SUMMARY:  - En bloc or extralesional resection means resection of the tumor in one piece together with a layer of healthy tissue: the margin is either marginal or wide. The prerequisite for an en bloc or extralesional spondylectomy is a tumor involvement of no more than one side of the posterior structures, so that a corridor can be created through which the spinal cord is released. This article presents a two-stage, combined anterior and posterolateral, three-level en bloc spondylectomy, and local flap wound coverage for a patient with a recurrent post-radiation sarcoma of the lumbar spine and infected wound after intralesional treatment. The patient had radiation therapy for an L4 Hodgkin’s lymphoma 5 years before the development of the post-radiation sarcoma. Two-stage, three-level en bloc spondylectomy was done through a combined anterior and posterolateral approach. The resection margins were microscopically negative. Dural tear occurred intraoperatively because of tightly adherent dense scar tissue. Two years after spondylectomy, there was no evidence of tumor or infection recurrence; however, the patient died from her lymphoma. In surgically difficult  spinal resections, we recommend the two-stage, combined anterior and posterolateral approach for en bloc spondylectomy. The staged procedure may provide for reduced perioperative complications and mortality, and meticulous dissection in the irradiated area, especially if infected. The combined approach  provides for easier and safer dissection of the tumor and the spine from the anterior elements under direct visual control, and wide tumor resection.

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[701]

TÍTULO / TITLE:  - Extraskeletal osteosarcoma with synchronous regional lymph node and soft tissue metastasis: a rare presentation of an uncommon tumour.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Orthop Surg Traumatol. 2012 Oct 16.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00590-012-1097-6

AUTORES / AUTHORS:  - Gulia A; Puri A; Jain S; Rekhi B; Juvekar S

INSTITUCIÓN / INSTITUTION:  - Tata Memorial Hospital, Room no: 43, Bone and Soft Tissue Services, E. Borges Marg, Parel, Mumbai, Maharashtra, 400012, India, aashishgulia@gmail.com.

RESUMEN / SUMMARY:  - Extraskeletal osteosarcoma is a rare soft tissue neoplasm arising from mesenchymal elements with characteristic production of osteoid. These tumours are known to have high rate of distant metastasis and dismal prognosis. We present a  rare case of extraskeletal osteosarcoma arising in medial aspect of knee joint with synchronous inguinal node and soft tissue metastasis. The patient was initially diagnosed as myositis ossificans at an outside institute and excised without prior imaging or biopsy. The patient presented to our hospital with recurrent lesion along with palpable inguinal lymph nodes and soft tissue metastasis in thigh. The patient underwent neoadjuvant chemotherapy and wide excision of the primary lesion, soft tissue metastasis and complete groin node dissection. We also discuss the importance of PET scan and intra-operative ultrasonography in the management of these lesions.

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[702]

TÍTULO / TITLE:  - Primary synovial osteochondromatosis of the ankle.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Mar 25;2013. pii: bcr2013009046. doi: 10.1136/bcr-2013-009046.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-009046

AUTORES / AUTHORS:  - Ozyurek S; Atik A; Sivrioglu AK; Ege T

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, Aksaz Military Hospital, Mugla, Istanbul, Turkey.

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[703]

TÍTULO / TITLE:  - Leiomyoma of the bladder.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Mar 25;2013. pii: bcr2013008749. doi: 10.1136/bcr-2013-008749.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-008749

AUTORES / AUTHORS:  - Muoka OE; Muoka O; Daruwalla P

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Lincoln County Hospital, Lincoln, UK.

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[704]

TÍTULO / TITLE:  - Secondary Chondrosarcoma of the Lumbosacral Region: Are any Bones Spared in the Multiple Hereditary Exostoses?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Diagn Res. 2012 Dec;6(10):1778-80. doi: 10.7860/JCDR/2012/4241.2611. Epub  2012 Dec 15.

            ●● Enlace al texto completo (gratuito o de pago) 7860/JCDR/2012/4241.2611

AUTORES / AUTHORS:  - Anantharamaiah H; Kalyani R; Kumar M L H; P V M

INSTITUCIÓN / INSTITUTION:  - Assistant Professor, Department of Pathology, Sri Devaraj Urs Medical College , Tamaka, Kolar 563101, Karnataka, India.

RESUMEN / SUMMARY:  - Osteochondromas are the most common benign bone tumors. Usually solitary, multiple osteochondromas (exostoses) are seen in patients with Multiple Hereditary Exostoses (MHE). Chondromatous transformation of lumbar osteochondroma in a patient with multiple exostoses is a rare phenomenon. We present a rare case of secondary chondrosarcoma of lumbar exostoses with patient presenting with symptoms of pain in the right lumbar region and paresis of right lower limb. Patients with multiple exostoses are prone to develop chondrosarcoma early in life. These patients need long term follow up with regular clinical and radiological examination.

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[705]

TÍTULO / TITLE:  - Unusual cutaneous Langerhans cell sarcoma without extracutaneous involvement.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2013 Feb 6;8:20. doi: 10.1186/1746-1596-8-20.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-8-20

AUTORES / AUTHORS:  - Li Y; Li B; Tian XY; Li Z

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, 58, Zhongshan Road II, Guangzhou, 510080, China.

RESUMEN / SUMMARY:  - Langerhans cell sarcoma (LCS) typically presents as cytologic atypia and clinical aggressiveness and may involve multiple organs during the progression of the disease. Primary skin LCS without any extra-cutaneous site association is extremely rare and only a few such cases have been described in the literature. We present a case of unusual primary LCS in skin occurring in a middle-aged male  patient. Physical examination revealed a large ulcerated cutaneous lesion and a smaller nodular lesion were located in the skin of the extensor side of his right knee. There was no regional lymph node or any other extra-cutaneous organ involvement. Histologically, typical large and pleomorphological tumor cells with epithelioid appearance and significantly malignant cytological features were observed to infiltrate in dermis and subcutaneous tissue. By immunohistochemistry, the tumor cells were positive for CD1a, S-100 protein and largerin strongly and diffusely. However, these cells were negative for CD3, CD20, CD21, pan-cytokeratin, HMB-45, Melan-A, and MPO. A diagnosis of primary cutaneous LCS was made. The patient received systemic chemotherapy of CHOP regimen, and was on a regular follow-up period for 12 months. There was no sign of relapse of tumor or any other extra-cutaneous organ involvement by whole body  positron emission tomography/computed tomography (PET/CT) study. Because LCS is a high-grade malignancy with poor prognosis, it suggests that strict histological analysis and thorough radiographic examination are necessary for accurately diagnosing this tumor even if cutaneous involvement presented only. VIRTUAL SLIDES: diagnosticpathology.diagnomx.eu/vs/6527428618381393.

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[706]

TÍTULO / TITLE:  - Management of forearm deformities with ulnar shortening more than 15 mm caused by hereditary multiple osteochondromas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Orthop Surg Traumatol. 2012 Jul 1.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00590-012-1033-9

AUTORES / AUTHORS:  - Tang ZW; Cao YL; Liu T; Chen T; Zhang XS

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, The 2nd Xiangya Hospital, Center South University, ren-min road, No.139, Changsha, 410011, Hunan, People’s Republic of China.

RESUMEN / SUMMARY:  - BACKGROUND: Treatment for forearm deformities caused by hereditary multiple osteochondromas is still controversial. The purpose of the study was to describe  the outcome of treatment with the combined use of ulnar lengthening and excision  of osteochondromas. METHODS: Fourteen patients with hereditary multiple osteochondromas had forearm deformities which belongs to type I Masada deformity. The mean relative ulnar shortening was 19.9 mm (range, 16-23). All patients ranging from 4 to 15 years old had operative treatment. Clinical evaluation involving the assessment of pain, activities of daily living, and range of motion of the wrist and forearm was performed. The radiographic evaluation was relative  ulnar shortening (RUS), radial articular angle (RAA), carpal slip (CS), and radial bowing. Besides, we also evaluated the amount of ulnar lengthening, external fixation time, and external fixation index. RESULTS: The mean EFT was 101 days (range, 84-133), and the mean external fixation index was 44.4 days/cm (range, 33.6-51.2). During the mean 43.1 months follow-up, four patients had mild pain and two patients had mild restriction of daily activities. The rotation of forearm and motion of wrist had increased except in Case 3. The RAA, CS, and radial bowing had been improved except in Case 6 and 7. In all patients, relative ulnar shortening had been corrected. According to the functional evaluation criteria recommended by Krimmer, there were ten excellent and four good. CONCLUSIONS: The combined use of ulna lengthening and excision of osteochondromas is a proper and effective treatment method to the type I Masada deformity with the relative ulnar shortening more than 15 mm.

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[707]

TÍTULO / TITLE:  - Hypercalcemia: an unusual manifestation of uterine leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Med. 2013;2013:815252. doi: 10.1155/2013/815252. Epub 2013 Feb 12.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/815252

AUTORES / AUTHORS:  - Garcha AS; Gumaste P; Cherian S; Khanna A

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, SUNY Upstate Medical University, 750 East Adams  Street, Syracuse, NY 13210, USA.

RESUMEN / SUMMARY:  - We present a case of hypercalcemia in a 79-year-old female likely secondary to uterine leiomyoma. To the best of our knowledge, hypercalcemia due to a benign tumor has only been described in five cases. Of these above five cases, uterine leiomyoma was thought to be the cause of hypercalcemia in three cases.

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[708]

TÍTULO / TITLE:  - Genomic EWS-FLI1 fusion sequences in Ewing sarcoma resemble breakpoint characteristics of immature lymphoid malignancies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(2):e56408. doi: 10.1371/journal.pone.0056408. Epub 2013 Feb 18.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0056408

AUTORES / AUTHORS:  - Berger M; Dirksen U; Braeuninger A; Koehler G; Juergens H; Krumbholz M; Metzler M

INSTITUCIÓN / INSTITUTION:  - University Hospital Erlangen, Department of Pediatrics, Erlangen, Germany.

RESUMEN / SUMMARY:  - Chromosomal translocations between the EWS gene and members of the ETS gene family are characteristic molecular features of the Ewing sarcoma. The most common translocation t(11;22)(q24;q12) fuses the EWS gene to FLI1, and is present in 85-90% of Ewing sarcomas. In the present study, a specifically designed multiplex long-range PCR assay was applied to amplify genomic EWS-FLI1 fusion sites from as little as 100 ng template DNA. Characterization of the EWS-FLI1 fusion sites of 42 pediatric and young adult Ewing sarcoma patients and seven cell lines revealed a clustering in the 5’ region of the EWS-breakpoint cluster region (BCR), in contrast to random distribution of breakpoints in the FLI1-BCR.  No association of breakpoints with various recombination-inducing sequence motifs was identified. The occurrence of small deletions and duplications at the genomic junction is characteristic of involvement of the non-homologous end-joining (NHEJ) repair system, similar to findings at chromosomal breakpoints in pediatric leukemia and lymphoma.

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[709]

TÍTULO / TITLE:  - Mucosal Kaposi sarcoma, a Rare Cancer Network study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Rare Tumors. 2012 Oct 10;4(4):e49. doi: 10.4081/rt.2012.e49. Epub 2012 Oct 17.

            ●● Enlace al texto completo (gratuito o de pago) 4081/rt.2012.e49

AUTORES / AUTHORS:  - Thariat J; Kirova Y; Sio T; Choussy O; Vees H; Schick U; Poissonnet G; Saada E; Thyss A; Miller RC

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Centre Laccasagne, Nice, France;

RESUMEN / SUMMARY:  - Kaposi’s sarcoma (KS) most often affect the skin but occasionally affect the mucosa of different anatomic sites. The management of mucosal KS is seldom described in the literature. Data from 15 eligible patients with mucosal KS treated between 1994 and 2008 in five institutions within three countries of the  Rare Cancer Network group were collected. The inclusion criteria were as follows: age >16 years, confirmed pathological diagnosis, mucosal stages I and II, and a minimum of 6 months’ follow-up after treatment. Head and neck sites were the most common (66%). Eleven cases were HIV-positive. CD4 counts correlated with disease  stage. Twelve patients had biopsy only while three patients underwent local resection. Radiotherapy (RT) was delivered whatever their CD4 status was. Median  total radiation dose was 16.2 Gy (0-45) delivered in median 17 days (0-40) with four patients receiving no RT. Six patients underwent chemotherapy and received from 1 to 11 cycles of various regimens namely vinblastin, caelyx, bleomycine, or interferon, whatever their CD4 counts was. Five-year disease free survival were 81.6% and 75.0% in patients undergoing RT or not, respectively. Median survival was 66.9 months. Radiation-induced toxicity was at worse grade 1-2 and was manageable whatever patients’ HIV status. This small series of mucosal KSs revealed that relatively low-dose RT is overall safe and efficient in HIV-positive and negative patients. Since there are distant relapses either in multicentric cutaneous or visceral forms in head and neck cases, the role of systemic treatments may be worth investigations in addition to RT of localized disease. Surgery may be used for symptomatic lesions, with caution given the risk of bleeding.

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[710]

TÍTULO / TITLE:  - Myxoma of the vomer bone.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Radiol Case Rep. 2013 Jan;7(1):12-7. doi: 10.3941/jrcr.v7i1.1284. Epub 2013 Jan 1.

            ●● Enlace al texto completo (gratuito o de pago) 3941/jrcr.v7i1.1284

AUTORES / AUTHORS:  - Besachio D; Quigley E 3rd; Orlandi R; Harnsberger H; Wiggins R 3rd

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, University of Utah, Salt Lake City, USA.

RESUMEN / SUMMARY:  - Myxomas of bone in the head and neck are rare tumors. We present a 68 year old female with pain and epistaxis who was found to have the first reported case of a myxoma arising within the vomer bone. Some atypical magnetic resonance imaging features are described, however, myxoma imaging features are often non-specific and typically evoke a benign differential diagnosis. Surgical excision is the treatment of choice.

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[711]

TÍTULO / TITLE:  - An inflammatory myofibroblastic tumour of the breast with ALK overexpression.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Feb 4;2013. pii: bcr0720114474. doi: 10.1136/bcr-07-2011-4474.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-07-2011-4474

AUTORES / AUTHORS:  - Zhou Y; Zhu J; Zhang Y; Jiang J; Jia M

INSTITUCIÓN / INSTITUTION:  - Southwest Hospital affiliated to Third Military Medical University, Chongqing, China. zhouyan126@yahoo.com.cn

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumours (IMTs), also known as inflammatory pseudotumours, include a diverse group of lesions characterised by inflammatory cell infiltration and variable fibrotic responses. Their occurrence in the breast is unusual. We present a case of an IMT of the breast in a 46-year-old woman who  complained of a breast mass with palpable axillary lymph node. The initial clinical diagnosis was breast cancer, and the patient underwent a conservative excision with apparently negative margins and an axillary lymph node excisional biopsy. A histopathological examination showed the presence of myofibroblastic spindle cells with mixed inflammatory infiltrates, and the pathological diagnosis was IMT. Significantly, the case we present here is unique in showing anaplastic  lymphoma kinase 1 (ALK1) overexpression and ALK1 gene amplification in IMT of the breast. Therefore, our case suggests that ALK1 gene amplification in IMT of the breast has important diagnostic and therapeutic implications.

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[712]

TÍTULO / TITLE:  - Fibrous dysplasia of the inferior turbinate.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Clin Exp Pathol. 2013;6(3):531-5. Epub 2013 Feb 15.

AUTORES / AUTHORS:  - Park HJ; Cho MS; Lee SS

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University School of Medicine Seoul, Korea.

RESUMEN / SUMMARY:  - Fibrous dysplasia (FD) is a benign skeletal disorder in which abnormally overgrowing bony lesion replaces normal bone. FD can affect one bone (monostotic  form) or multiple bones (polyostotic form). The craniofacial bones are involved in about 10% of subjects with monostotic FD. However, its occurrence in the sinonasal tract is very rare. We report a case of monostotic FD developed only in the inferior turbinate in a 29-year-old woman. To the best of our knowledge, it is the second report of monostotic FD involving the inferior turbinate in the medical literature. We, therefore, report this rare case with a review of literature.

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[713]

TÍTULO / TITLE:  - Chondrosarcoma apoplexy in thoracic spine.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Korean Neurosurg Soc. 2013 Jan;53(1):46-8. doi: 10.3340/jkns.2013.53.1.46. Epub 2013 Jan 31.

            ●● Enlace al texto completo (gratuito o de pago) 3340/jkns.2013.53.1.46

AUTORES / AUTHORS:  - Kim SW; Kim MS; Jung YJ

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, College of Medicine, Yeungnam University, Daegu, Korea.

RESUMEN / SUMMARY:  - Chondrosarcoma is a very uncommon malignant primary bone tumor, especially, it occurs extremely rare in the spine. A 52-year-old man was admitted to the emergency room with sudden paraplegia. Twelve hours prior to a paraplegic event,  he visited an outpatient clinic with discomfort and tenderness around the medial  border of the right scapular, and his neurologic status was absolutely intact. Magnetic resonance imaging showed a lobulated soft tissue mass from T3 to T5, which extended to the epidural space. Computed tomography scans showed soft tissue mass on the spinal posterior arch and osteolytic change of the adjacent bony structures. Emergent surgery was performed and the lesion was removed. Dark  reddish blood and gel-like material were encountered around the dura and posterior arch during the operation. Multiple pulmonary nodules were found on a chest CT scan and a biopsy of one of them had been proven to be a metastasis of chondrosarcoma. The histologic examination showed dedifferentiated chondrosarcoma. The patient’s neurologic deficit was improved slowly from ASIA A  to ASIA D. Chondrosarcoma in the spine is extremely rare, even more with acute hemorrhage and sudden expansion into the epidural space. We named it chondrosarcoma apoplexy. We should consider the possibility of a hemorrhagic event when the patient’s neurologic deficit worsens suddenly with spinal bone tumor.

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[714]

TÍTULO / TITLE:  - ZNF-mediated resistance to imatinib mesylate in gastrointestinal stromal tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e54477. doi: 10.1371/journal.pone.0054477. Epub 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0054477

AUTORES / AUTHORS:  - Rink L; Ochs MF; Zhou Y; von Mehren M; Godwin AK

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America. Lori.Rink@fccc.edu

RESUMEN / SUMMARY:  - Although imatinib mesylate (IM) has transformed the treatment of gastrointestinal stromal tumors (GIST), many patients experience primary/secondary drug resistance. In a previous study, we identified a gene signature, consisting mainly of Kruppel-associated box (KRAB) domain containing zinc finger (ZNF) transcriptional repressors that predict short-term response to IM. To determine if these genes have functional significance, a siRNA library targeting these genes was constructed and applied to GIST cells in vitro. These screens identified seventeen “IM sensitizing genes” in GIST cells (sensitization index (SI) <0.85 ratio of drug/vehicle) with a false discovery rate (FDR) <15%, including twelve ZNF genes, the majority of which are located within the HSA19p12-13.1 locus. These genes were shown to be highly specific to IM and another tyrosine kinase inhibitor (TKI), sunitinib, in GIST cells. In order to determine mechanistically how these ZNFs might be modulating response to IM, RNAi approaches were used to individually silence genes within the predictive signature in GIST cells and expression profiling was performed. Knockdown of the  14 IM-sensitizing genes (10 ZNFs) universally led to downregulation of six genes, including TGFb3, periostin, and NEDD9. These studies implicate a role of KRAB-ZNFs in modulating response to TKIs in GIST.

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[715]

TÍTULO / TITLE:  - Fibrolipoma of the eustachian ostium.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Feb 25;2013. pii: bcr2013008794. doi: 10.1136/bcr-2013-008794.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-008794

AUTORES / AUTHORS:  - Thakur JS; Saluja M; Sharma DR; Mohindroo NK

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology and Head and Neck Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India. anujagdeep@yahoo.co.in

RESUMEN / SUMMARY:  - Nasopharyngeal fibrolipoma is extremely rare, with only four case reports in the  literature. However, lipoma of the eustachian tube is the rarest with a single case report in the literature. A 50-year-old woman presented with obstruction of  both nostrils for the past 1 year. CT scan showed a mass in the postnasal space extending from the right side of the nasopharynx to the oropharynx. The nasal endoscopy found a polypoidal mass arising from the posterior-inferior margin of the right eustachian tube ostium and extending to the oropharynx. Histopathological examination of the excised polyp found features suggestive of fibrolipoma. Fibrolipoma is characterised by prominent bundles of mature collagenous or myxocollagenous stroma intermixed with mature adipocytes. CT is useful in the diagnosis of lipoma but MRI is preferable. This is the second case  of eustachian tube fibrolipoma to be reported in the literature that emphasises the role of nasal endoscopy and rarity of this tumour.

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[716]

TÍTULO / TITLE:  - De novo appearance of a choroidal osteoma in an eye with previous branch retinal  vein occlusion.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ophthalmic Surg Lasers Imaging Retina. 2013 Jan 1;44(1):77-80. doi: 10.3928/23258160-20121221-17.

            ●● Enlace al texto completo (gratuito o de pago) 3928/23258160-20121221-17

AUTORES / AUTHORS:  - Adhi M; Bryant JS; Alwassia AA; Chen C; Duker JS

RESUMEN / SUMMARY:  - This report describes the de novo appearance of a choroidal osteoma occurring 8 years after laser photocoagulation for previous branch retinal vein occlusion (BRVO). A 62-year old man presented with an asymptomatic yellowish orange lesion  in the macula on fundus examination of his left eye during a regular follow-up visit for bilateral BRVO associated with macular edema that had previously been treated with laser photocoagulation. The lesion was observed for 1.5 years until  a decrease in vision occurred. Fundus photography revealed a yellow-to-orange, well-defined lesion in the macular region. Fluorescein angiography was consistent with choroidal neovascularization (CNV). Optical coherence tomography and B-scan  ultrasonography showed features consistent with choroidal osteoma. This is the first report of the de novo appearance of a choroidal osteoma occurring years after laser photocoagulation for BRVO. CNV developed secondary to the lesion, which was treated with intravitreal bevacizumab, leading to subjective and anatomic improvement.

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[717]

TÍTULO / TITLE:  - Dkk-3, a secreted wnt antagonist, suppresses tumorigenic potential and pulmonary  metastasis in osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2013;2013:147541. doi: 10.1155/2013/147541. Epub 2013 Feb 10.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/147541

AUTORES / AUTHORS:  - Lin CH; Guo Y; Ghaffar S; McQueen P; Pourmorady J; Christ A; Rooney K; Ji T; Eskander R; Zi X; Hoang BH

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, CHOC Children’s Hospital, 455 South Main Street, Orange,  CA 92868, USA ; Department of Orthopaedic Surgery, University of California, Irvine, 101 The City Drive South, Orange, CA 92868, USA.

RESUMEN / SUMMARY:  - Osteosarcoma (OS) is the most common primary bone malignancy with a high propensity for local invasion and distant metastasis. Despite current multidisciplinary treatments, there has not been a drastic change in overall prognosis within the past 2 decades. Dickkopf-3 protein (Dkk-3/REIC) has been known to inhibit canonical Wnt/ beta -catenin pathway, and its expression has been shown to be downregulated in OS cell lines. Using in vivo and in vitro studies, we demonstrated that Dkk-3-transfected 143B cells inhibited tumorigenesis and metastasis in an orthotopic xenograft model of OS. Inoculation  of Dkk-3-transfected 143B cell lines into nude mice showed significant decreased  tumor growth and less metastatic pulmonary nodules (88.7%) compared to the control vector. In vitro experiments examining cellular motility and viability demonstrated less anchorage-independent growth and decreased cellular motility for Dkk-3-transfected 143B and SaOS2 cell lines compared to the control vector. Downstream expressions of Met, MAPK, ALK, and S1004A were also downregulated in Dkk-3-transfected SaOS2 cells, suggesting the ability of Dkk-3 to inhibit tumorigenic potential of OS. Together, these data suggest that Dkk-3 has a negative impact on the progression of osteosarcoma. Reexpressing Dkk-3 in Dkk-3-deficient OS tumors may prove to be of benefit as a preventive or therapeutic strategy.

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[718]

TÍTULO / TITLE:  - miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Cell Int. 2013 Mar 4;13(1):21. doi: 10.1186/1475-2867-13-21.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1475-2867-13-21

AUTORES / AUTHORS:  - Iida K; Fukushi J; Matsumoto Y; Oda Y; Takahashi Y; Fujiwara T; Fujiwara-Okada Y; Hatano M; Nabashima A; Kamura S; Iwamoto Y

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Maidashi3-1-1, Fukuoka, 812-8582, Japan. fukushi@med.kyushu-u.ac.jp.

RESUMEN / SUMMARY:  - BACKGROUND: Diverse functions of microRNAs (miRNAs), including effects on tumorigenesis, proliferation, and differentiation, have been reported, and several miRNAs have also been demonstrated to play an important role in apoptosis. In this study, we investigated the possible role that miRNAs may play  in the development of chemoresistance in Ewing sarcoma/primitive neuroectodermal  tumor (EWS). METHODS: We screened doxorubicin (Dox)-resistant EWS cells to identify any distinct miRNA sequences that may regulate the chemoresistance of EWS cells. The effects of miRNAs were evaluated using a chemosensitivity assay. The possible target genes of the miRNAs were predicted using a web-based prediction program. RESULTS: We found miR-125b to be upregulated in two different Dox-resistant EWS cell lines. The upregulation of miR-125b was also confirmed in  the EWS tumors having survived chemotherapy regimen which includes doxorubicin. When miR-125b was knocked down in EWS cells, both the Dox-resistant and parental  cells showed an enhanced sensitivity to doxorubicin, which was associated with the upregulation of the pro-apoptotic molecules, p53 and Bak. Inversely, the overexpression of miR-125b in parental EWS cells resulted in enhanced drug resistance, not only to doxorubicin, but also to etoposide and vincristine. CONCLUSIONS: Our findings suggest that miR-125b may play a role in the development of chemoresistance in EWS by suppressing the expression of the apoptotic mediators, such as p53 and Bak.

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[719]

TÍTULO / TITLE:  - NAB2-STAT6 Fusions Are a Hallmark of Solitary Fibrous Tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Discov. 2013 Mar;3(3):OF18. doi: 10.1158/2159-8290.CD-RW2013-016. Epub 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1158/2159-8290.CD-RW2013-016

RESUMEN / SUMMARY:  - NAB2-STAT6 gene fusions occur in the vast majority of solitary fibrous tumors.

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[720]

TÍTULO / TITLE:  - Multiple causes for an ischemic stroke: myxoma, papillary fibroelastomas and patent foramen ovale.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - HSR Proc Intensive Care Cardiovasc Anesth. 2012;4(3):187-91.

AUTORES / AUTHORS:  - Roque J; Silva F; Arruda Pereira R; Cravino J

INSTITUCIÓN / INSTITUTION:  - Department of Cardiothoracic Surgery, Hospital de Santa Maria, Lisbon, Portugal.

RESUMEN / SUMMARY:  - We report a case in which multiple uncommon causes of an ischemic vascular accident coexisted in the same patient. The patient was admitted with signs of acute stroke. Investigation workup revealed a left atrial tumor (myxoma) and a patent foramen ovale. Intraoperatively, transesophageal echocardiography added new information: papillary fibroelastomas were found in the aortic valve. This finding dictated a change in the surgical plan, adding resection of aortic valve  masses to the planned excision of the left atrial tumor and patent foramen ovale  closure. The uniqueness of this case derives from the coexistence of rare primary cardiac tumors. There are only five cases in literature of myxoma concomitant with fibroelastoma and the occurrence of multiple fibroelastoma is also extremely rare. Moreover this case emphasizes the benefit of the intraoperative use of transesophageal echocardiography to improve the diagnosis and management of cardiac surgical patients.

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[721]

TÍTULO / TITLE:  - Large uterine neurofibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Minim Invasive Gynecol. 2013 Mar;20(2):259-61. doi: 10.1016/j.jmig.2012.11.004.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jmig.2012.11.004

AUTORES / AUTHORS:  - Gokavi SE; Jadhav R; Reddy P

INSTITUCIÓN / INSTITUTION:  - Centre for Fertility Care and Laparoscopic Surgery, Near Basel Mission Church, Hubli, Karnataka, India. Electronic address: segokavi@yahoo.com.

RESUMEN / SUMMARY:  - Herein we report a rare case of a large uterine neurofibroma. The patient reported infertility and nonspecific pelvic symptoms. Physical examination and ultrasonography revealed a mass of uterine origin with echo texture similar to that of a myoma. With a provisional diagnosis of a myomatous uterus, laparoscopic myomectomy was attempted. The mass, which measured 13 x 9 x 8 cm, was noted to be arising from the uterine fundus and extending into the left broad ligament. Histopathologic examination revealed a neurofibroma, which was confirmed at immunohistochemical analysis of the specimen. Most neurofibromas arise as subcutaneous swellings, and large neurofibromas arising from the myometrium are rare. Deep-tissue neurofibromas are known to recur and are associated with a higher probability of becoming malignant.

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[722]

TÍTULO / TITLE:  - Curcumin potentiates rhabdomyosarcoma radiosensitivity by suppressing NF-kappaB activity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(2):e51309. doi: 10.1371/journal.pone.0051309. Epub 2013 Feb 7.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0051309

AUTORES / AUTHORS:  - Orr WS; Denbo JW; Saab KR; Ng CY; Wu J; Li K; Garner JM; Morton CL; Du Z; Pfeffer LM; Davidoff AM

INSTITUCIÓN / INSTITUTION:  - University of Tennessee Health Science Center, Department of Surgery, Memphis, Tennessee, USA.

RESUMEN / SUMMARY:  - Ionizing radiation (IR) is an essential component of therapy for alveolar rhabdomyosarcoma. Nuclear factor-kappaB (NF-kappaBeta) transcription factors are  upregulated by IR and have been implicated in radioresistance. We evaluated the ability of curcumin, a putative NF-kappaBeta inhibitor, and cells expressing genetic NF- kappaBeta inhibitors (IkappaBalpha and p100 super-repressor constructs) to function as a radiosensitizer. Ionizing radiation induced NF-kappaBeta activity in the ARMS cells in vitro in a dose- and time-dependent manner, and upregulated expression of NF-kappaBeta target proteins. Pretreatment  of the cells with curcumin inhibited radiation-induced NF-kappaBeta activity and  target protein expression. In vivo, the combination of curcumin and IR had synergistic antitumor activity against Rh30 and Rh41 ARMS xenografts. The greatest effect occurred when tumor-bearing mice were treated with curcumin prior to IR. Immunohistochemistry revealed that combination therapy significantly decreased tumor cell proliferation and endothelial cell count, and increased tumor cell apoptosis. Stable expression of the super-repressor, SR-IkappaBalpha,  that blocks the classical NF-kappaB pathway, increased sensitivity to IR, while expression of SR-p100, that blocks the alternative pathway, did not. Our results  demonstrate that curcumin can potentiate the antitumor activity of IR in ARMS xenografts by suppressing a classical NF-kappaBeta activation pathway induced by  ionizing radiation. These data support testing of curcumin as a radiosensitizer for the clinical treatment of alveolar rhabdomyosarcoma. IMPACT OF WORK: The NF-kappaBeta protein complex has been linked to radioresistance in several cancers. In this study, we have demonstrated that inhibiting radiation-induced NF-kappaBeta activity by either pharmacologic (curcumin) or genetic (SR-IkappaBalpha) means significantly enhanced the efficacy of radiation therapy  in the treatment of alveolar rhabdomyosarcoma cells and xenografts. These data suggest that preventing the radiation-induced activation of the NF-kappaBeta pathway is a promising way to improve the antitumor efficacy of ionizing radiation and warrants clinical trials.

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[723]

TÍTULO / TITLE:  - Recurrent atypical fibroxanthoma of the limbus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Mar 15;2013. pii: bcr2013008762. doi: 10.1136/bcr-2013-008762.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-008762

AUTORES / AUTHORS:  - Ullrich K; Wells J; Brennan C; Craig J

INSTITUCIÓN / INSTITUTION:  - Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia,  Australia.

RESUMEN / SUMMARY:  - We report an unusual presentation of recurrent atypical fibroxanthoma of the limbus. Clinical and histological appearances, as well as management are discussed and the current literature is reviewed.

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[724]

TÍTULO / TITLE:  - Classic tongue lipoma: a common tumour at a rare site.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 30;2013. pii: bcr2012007987. doi: 10.1136/bcr-2012-007987.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007987

AUTORES / AUTHORS:  - Magadum D; Sanadi A; Agrawal JM; Agrawal MS

INSTITUCIÓN / INSTITUTION:  - Department of Oral Pathology, Bharti Vidyapeeth Dental College & Hospital, Sangli, Maharashtra, India.

RESUMEN / SUMMARY:  - Lipoma is the commonest benign tumour occurring at any anatomical site where fat  is present, but occurrence in the oral cavity is rare. Tongue which is totally devoid of fat cells is a rare site for lipoma. This is one such rare case of the  universal tumour, presenting at the lateral margin of the tongue, for which complete tumour excision was done. Macroscopically the mass had a hard consistency and measured 3.0 x 2.0 cm. From microscopic examination, diagnosis of lipoma was made. Recurrence of tongue lipoma is rare.

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[725]

TÍTULO / TITLE:  - Primary Ewing’s sarcoma of the skull.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 30;2013. pii: bcr2012007979. doi: 10.1136/bcr-2012-007979.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007979

AUTORES / AUTHORS:  - Rahman A; Bhandari PB; Hoque SU; Wakiluddin AN

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. bijoun14@yahoo.com

RESUMEN / SUMMARY:  - Ewing’s sarcoma, a highly malignant bone tumour, typically affects the pelvis and the long bones of the lower extremities in children and young adults and primary  involvement of the skull is rare. Here, we present a case of primary Ewing’s sarcoma of the skull with localised swelling in a young adult that involved the frontoparietal region of the skull and was very aggressive in nature. Even with aggressive surgery, the patient had multiple recurrences within 1 month of surgery and ultimately the patient died.

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[726]

TÍTULO / TITLE:  - Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Womens Health. 2013;5:93-100. doi: 10.2147/IJWH.S38800. Epub 2013 Feb 27.

            ●● Enlace al texto completo (gratuito o de pago) 2147/IJWH.S38800

AUTORES / AUTHORS:  - Sabry M; Halder SK; Allah AS; Roshdy E; Rajaratnam V; Al-Hendy A

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt ; Department of Obstetrics and Gynecology, Center for Women’s Health Research, Meharry Medical College, Nashville, TN, USA.

RESUMEN / SUMMARY:  - PURPOSE: Currently there is no effective medicinal treatment for uterine fibroids (UFs), a common health disorder that affects women of reproductive age. Identification of modifiable risk factors such as vitamin D (Vit D) deficiency could help develop novel strategies for the prevention and/or treatment of UFs. The purpose of this study was to identify whether low serum Vit D3 levels correlate with increased risk of UFs. METHODS: A total of 154 premenopausal women were recruited for this cross-sectional study. The control group comprised 50 subjects with a normal, fibroid-free uterine structure, confirmed by transvaginal ultrasonography. The 104 case subjects had at least one fibroid lesion that was 2 cm(3) in volume or larger, confirmed by transvaginal ultrasonography. For each case subject, total uterine volume and total volume of all existing fibroids were measured in three perpendicular planes, with volume determined according to the prolate ellipse formula (a x b x c x 0.523), where a is height, b is width, and c is depth. Serum Vit D [25(OH) D3] levels were measured by radioimmunoassay. The independent t-test was used to compare serum Vit D levels across groups. Correlations were assessed by Spearman’s rank correlation test. RESULTS: Lower serum 25-(OH) Vit D levels were significantly associated with the occurrence of UFs (P = 0.01). A statistically significant inverse correlation was also observed between serum 25-(OH) Vit D levels and total UF volume (r = -0.31; P = 0.002) within the case cohort. Subjects with larger fibroid volumes had lower serum Vit  D levels and vice versa. Data stratified for ethnicity showed a statistically significant inverse correlation between serum 25-(OH) Vit D levels and total fibroid volume in black subjects (r = -0.42; P = 0.001). An inverse correlation was also evident in white subjects (r = -0.86; P = 0.58) but this did not reach statistical significance. CONCLUSION: Lower serum Vit D levels are inversely correlated with UF burden in different ethnic groups. Vit D deficiency is a possible risk factor for the occurrence of UFs.

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[727]

TÍTULO / TITLE:  - Clear cell sarcoma of the neck which metastasized to the mammary gland.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol. 2013 Jan;6(1):55-61. doi: 10.1159/000345843. Epub 2013 Jan 22.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000345843

AUTORES / AUTHORS:  - Fukada I; Nishimura S; Tanabe M; Morizono H; Makita M; Gomi N; Horii R; Akiyama F; Iwase T

INSTITUCIÓN / INSTITUTION:  - Department of Breast Medical Oncology, the Cancer Institute Hospital of the Japanese Foundation for Cancer Research, and the Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan.

RESUMEN / SUMMARY:  - Malignant neoplasms very rarely metastasize to the mammary gland, the incidence of which is reported as 0.5-2%. Clear cell sarcoma is a rare neoplasm, accounting for approximately 1% of all soft tissue tumors, which commonly occurs in the distal extremities of young adults aged approximately 20 to 40 years. So it is also called malignant melanoma of soft parts because it frequently produces melanin. We report a case of a 26-year-old woman who presented with a neck mass.  The mass was surgically removed, and pathological diagnosis was clear cell sarcoma of the neck, harboring the EWS-ATF1 chimeric gene. Computed tomography detected a right breast mass 11 months after operation. She was referred to our department, and the right breast tumor was resected. Histopathological examination revealed a 2.5-cm, well-defined mass composed of nests of small, spindle-shaped tumor cells with abundant, clear cytoplasm containing round nuclei and prominent nucleoli. The tumor cells were immunohistochemically positive for HMB45, S-100, and Melan-A. These findings led to a diagnosis of metastasis of clear cell sarcoma to the mammary gland. This is the first report of clear cell sarcoma of the neck which metastasized to the mammary gland.

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[728]

TÍTULO / TITLE:  - Distant metastasis from benign solitary fibrous tumor of the kidney.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Nephrol Urol. 2013 Jan;3(1):1-8. doi: 10.1159/000346850. Epub 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000346850

AUTORES / AUTHORS:  - Sasaki H; Kurihara T; Katsuoka Y; Nakano T; Yoshioka M; Miyano S; Sato Y; Uejima I; Hoshikawa M; Takagi M; Chikaraishi T

INSTITUCIÓN / INSTITUTION:  - Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan.

RESUMEN / SUMMARY:  - Solitary fibrous tumor (SFT) rarely occurs in the kidneys, and only one reported  case of renal SFT has shown distant metastasis. We report the second case of renal SFT exhibiting distant metastasis. A 48-year-old man was referred to our hospital because of a right renal mass. An abdominal CT scan detected a large renal tumor, which was suspected to be a renal cell carcinoma. Right radical nephrectomy was performed, and the tumor was found to measure 28 x 18 x 10 cm. The pathological diagnosis was benign solitary fibrous tumor of the kidney. Eight years after the operation, lung and liver metastases developed. Pulmonary segmentectomy and partial hepatectomy were performed. The pathological diagnoses  of these resected tissue specimens were compatible with benign SFT.

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[729]

TÍTULO / TITLE:  - Intramuscular myxoma in the chest wall.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gen Thorac Cardiovasc Surg. 2013 Mar 9.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11748-013-0231-7

AUTORES / AUTHORS:  - Ibi T; Akiyama H; Okada D; Yoshino N; Hirai K; Shimizu K

INSTITUCIÓN / INSTITUTION:  - The Department of Cardiovascular and Thoracic Surgery, Nippon Medical School Chiba Hokuso Hospital, 1715 Kamagari Inzai-shi, Chiba, 270-1694, Japan, t-ibi@nms.ac.jp.

RESUMEN / SUMMARY:  - Intramuscular myxomas are benign soft-tissue tumors that often develop in the thigh. A 66-year-old woman was referred with an abnormal shadow on chest roentgenogram. The tumor was well defined and smooth and originated from the second intercostal space. Positron emission tomography showed no accumulation of  18F-fluorodeoxyglucose in the tumor. The patient attended the outpatient department for follow-up care. Because the mass grew slightly after 52 months, the patient underwent complete removal by video-assisted thoracoscopic surgery. On histopathological examination, the tumor was diagnosed as an intramuscular myxoma in the chest wall. The patient has had no recurrence 3 years after surgery. A case of intramuscular myxoma in the chest wall, completely resected by video-assisted thoracoscopic surgery, is reported. A well-defined, smooth, homogeneous mass in the chest wall may therefore be intramuscular myxoma.

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[730]

TÍTULO / TITLE:  - A large vascular leiomyoma of the leg.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Ultrasound. 2012 Jun;15(2):121-3. doi: 10.1016/j.jus.2011.10.007. Epub 2011 Oct 29.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jus.2011.10.007

AUTORES / AUTHORS:  - Cigna E; Maruccia M; Malzone G; Malpassini F; Soda G; Drudi FM

INSTITUCIÓN / INSTITUTION:  - Department of Plastic Surgery, Policlinico Umberto I, University of Rome “Sapienza”, Italy.

RESUMEN / SUMMARY:  - A 69-year-old woman with a subcutaneous, large vascular leiomyoma of the leg is presented. The patient had a painful, slow-growing, right medial malleolus mass.  Clinical symptoms, US images and histopathologic features are reported. Vascular  leiomyoma should be included in the differential diagnosis of painful, lower extremity subcutaneous masses also in lesions of larger dimensions.

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[731]

TÍTULO / TITLE:  - Breast fibromatosis mimicking breast carcinoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Proc (Bayl Univ Med Cent). 2013 Jan;26(1):22-4.

AUTORES / AUTHORS:  - Ha KY; Deleon P; Hamilton R

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Baylor University Medical Center at Dallas.

RESUMEN / SUMMARY:  - Fibromatosis arising from the breast, also referred to as desmoid tumor, aggressive fibromatosis, or low-grade fibrosarcoma, is a rare benign entity, accounting for only 0.2% of all breast tumors. Associations with familial multicentric fibromatosis and trauma, including that resulting from surgical intervention, have been reported. Awareness of this lesion is important, as the diagnosis has often been confused with that of breast carcinoma. We present the case of a 30-year-old white woman who presented with a palpable mass within the medial portion of her right breast. She reported breast carcinoma in both her paternal grandmother and maternal aunt. Subsequent mammographic and sonographic evaluation demonstrated an irregular solid mass within the posteromedial portion  of the right breast. Ultrasound-guided core needle biopsy revealed low-grade myofibroblastic proliferation consistent with breast fibromatosis. The lesion was surgically resected via wide local excision. Follow-up mammograms performed 1 and 2 years after resection demonstrated no radiographic evidence of recurrence.

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[732]

TÍTULO / TITLE:  - Aggressive angiomyxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Interv Imaging. 2013 Feb 26. pii: S2211-5684(13)00010-7. doi: 10.1016/j.diii.2013.01.009.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.diii.2013.01.009

AUTORES / AUTHORS:  - Gay F; Champigneulle J; Tortuyaux JM; Cuny T; Regent D; Laurent-Croise V

INSTITUCIÓN / INSTITUTION:  - Service de radiologie, imagerie Guilloz, hopital Central, 29, avenue du Marechal-de-Lattre-de-Tassigny, 54000 Nancy, France. Electronic address: frederique.gay1@gmail.com.

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[733]

TÍTULO / TITLE:  - A rare occurrence of peripheral ossifying fibroma in the first decade of life and its management.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Mar 15;2013. pii: bcr2012009084. doi: 10.1136/bcr-2013-009084.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2013-009084

AUTORES / AUTHORS:  - Vyawahare S; Banda NR; Barodiya A; Banda VR

INSTITUCIÓN / INSTITUTION:  - Department of Pedodontics, Modern Dental College and Research Centre, Nagpur, Maharashtra, India.

RESUMEN / SUMMARY:  - Localised growths are commonly seen on the gingiva. Many of these enlargements are considered to be reactive rather than neoplastic in nature. Clinically, differentiating one from the other as a specific entity is often not possible. Clinical knowledge and histopathological examination is needed to positively identify the lesion. The peripheral ossifying fibroma is one such lesion. We report a rare case in a 10-year-old female patient with a peripheral ossifying fibroma in the mandible exhibiting a significant increase in size within a short  duration of 6 months.

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[734]

TÍTULO / TITLE:  - An intradural cervical chordoma mimicking schwannoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Inj Violence Res. 2012 Nov;4(3 Suppl 1). pii: Paper No. 83.

AUTORES / AUTHORS:  - Samadian M; Shafizad M

INSTITUCIÓN / INSTITUTION:  - Neurosurgery Department, Loghman Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

RESUMEN / SUMMARY:  - Chordoma is a relatively rare tumor originating from the embryonic remnants of the notochord. This is an aggressive, slow growing and invasive tumor. It occurs  mostly at the two ends of neuroaxis which is more frequent in the sacrococcygeal  region. Chordoma in vertebral column is very rare. This tumor is extradural in origin and compresses neural tissues and makes the patient symptomatic. This tumor found extremely rare in the spinal region as an intradural tumor. The present study reports a rare case of intradural chordoma tumor as well as its clinical manifestations and treatment options. CASE: The patient was a 50-year-old female presented with 9 months history of progressively worsening neck pain, cervical spine chordoma resembling neurinoma and right arm numbness. Physical examination showed no weakness in her limbs, but she had upward plantar  reflex and mild hyperreflexia. In a magnetic resonance imaging (MRI) scan of the  cervical spine there was an ill-defined enhancing mass in the posterior aspect of C2-C3 body caused cord compression more severe in right side as well as foraminal scalloping. The patient underwent surgery and after midline posterior cervical incision and paravertebral muscle stripping a laminectomy was performed from C1 through C4 using a high speed drill. Needle biopsy revealed chordoma on frozen section and all of accessible parts of tumor were excised. The gross and microscopic histopathological appearance was consistent with chordoma. Chordomas  are malignant tumors that arise from remains of embryonic notochord. These ectopic rests of notochord termed “ecchordosis physaliphora “can be found in approximately 2% of autopsies. These are aggressive, slow growing, locally invasive and destructive tumors those occur in the midline of neuroaxis. They generally thought to account for 2% to 4% of all primary bone neoplasms and 1% to 4% malignant bone neoplasms. They are the most frequent primary malignant spinal  tumors after plasmacytomas. The incidence has been estimated to be 0.51 cases per million. The most common location is sacrococcygeal region followed by the clivus. These two locations account for approximately 90% of chordomas. Of the tumors that do not arise in the sacrum or clivus, half occur in the cervical region, with the remainder found in the lumbar or thoracic region, in descending  order of frequency. Cervical spine chordomas account for 6% of all cases. Distal  metastasis most often occurs in young patients, those with sacrococcygeal or vertebral tumors, and those with atypical histological features. These tumors usually spread to contiguous anatomical structures, but they may be found in distant sites (skin, musculoskeletal system, brain, and other internal organs). Seeding of the tumor has also been reported, and the likely mechanism seems to be tumor cell of contamination during the surgical procedures. The usual radiological findings in chordomas of spine are destructive or lytic lesions with occasional sclerotic changes. They tend to lie anterolateral, rather than dorsal  towards the cord, and reportedly known to invade the dura. The midline location,  destructive nature, soft tissue mass formation and calcification are the radiological hallmarks of chordomas. Computed Tomography (CT) scan is the best imaging modality to delineate areas of osteolytic, osteosclerotic, or mixed areas of bone destruction.Chordoma is usually known as a hypovascular tumor which grows in a lobulated manner. Septal enhancement which reflects a lobulated growth pattern is seen in both CT and MRI and even in gross examination. Other epidural  tumors include neurinoma, neurofibroma, meningioma, neuroblastoma, hemangioma, lymphoma and metastases. Their differentiation from chordoma may be difficult due to the same enhancement pattern on CT and MRI. A dumbbell-shaped chordoma is a rare pathogenic condition. The dumbbell shape is a characteristic finding of neurinomas in spine but in spinal neurinomas extention to transverse foramina has not yet been reported. Although our case mimicked a dumbbell shaped neurogenic tumor, its midline location and destructive pattern were characteristic feature indicating a clue to the diagnosis of chordoma that was already confirmed with histopathology. This unusual behavior of tumor extension can be explained by the  soft and gelatinous nature of the tumor enabling the mass to extend or creep into the existing adjacent anatomical structures. KEYWORDS: Cervical Chordoma, Intradural, Computed tomography.

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[735]

TÍTULO / TITLE:  - Liposarcoma of the spermatic cord.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Feb 20;2013. pii: bcr2012008141. doi: 10.1136/bcr-2012-008141.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-008141

AUTORES / AUTHORS:  - Aziz R; Jamil A; Alubaidi K; Jamil W

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, South West Acute Hospital, Enniskillen, UK. drrizwanaziz@hotmail.com

RESUMEN / SUMMARY:  - A 43-years-old male patient presented through general practitioner with a complaint of right scrotal mass and was operated through inguinal approach. A 4 cm mass was excised and was found to be a liposarcoma of the spermatic cord upon  histopathology, which is a diagnostic dilemma and very rare entity.

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[736]

TÍTULO / TITLE:  - Mediastinal leiomyosarcoma concurrent with intra-aortic thrombosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Feb 20;2013. pii: bcr2012007527. doi: 10.1136/bcr-2012-007527.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007527

AUTORES / AUTHORS:  - Yoshida M; Ando S; Naito Y; Yano H

INSTITUCIÓN / INSTITUTION:  - Department of Cardiology, Saiseikai Futsukaichi Hospital, Fukuoka city, Japan.

RESUMEN / SUMMARY:  - We report a case of a large intra-aortic thrombosis in an 83-year-old woman concurrent with metastatic mediastinal leiomyosarcoma. Imaging studies incidentally detected a mediastinal malignant tumour metastasising to bilateral adrenals and an extensive intra-aortic mass that was suspected to be intra-aortic thrombosis. One month later massive embolism developed in the lower limb and her  condition deteriorated rapidly resulting in death. Autopsy revealed diffused proliferation of highly pleomorphic atypical cells accompanied by necrosis in the mediastinum tumours and bilateral adrenal glands. Leiomyosarcoma metastasising to bilateral adrenals was confirmed by the results of immunostaining. The intra-aortic mass suggested that the fragmented thrombus might be the cause of a  sudden lower-limb embolism. Microscopic examination showed that the mass lesion in the aortic arch was composed of a blood clot containing neutrophils. We report this case because leiomyosarcoma arising from the mediastinum and, especially, associated with an extraordinarily large intra-aortic thrombosis is very rare.

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[737]

TÍTULO / TITLE:  - Esophageal lipoma: a rare tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Radiol Case Rep. 2012 Jul;6(7):17-22. doi: 10.3941/jrcr.v6i7.1015. Epub 2012 Jul 1.

            ●● Enlace al texto completo (gratuito o de pago) 3941/jrcr.v6i7.1015

AUTORES / AUTHORS:  - Feldman J; Tejerina M; Hallowell M

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Hahnemann University Hospital, Philadelphia, PA 19102, USA. jsfeldma@gmail.com

RESUMEN / SUMMARY:  - Esophageal lipomas are rare tumors, making up 0.4% of all digestive tract benign  neoplasms. Most of these lesions are clinically silent as a result of their small size, however, the majority of lesions over 4 cm have been reported to cause dysphagia, regurgitation and/or epigastralgia. We report a case of a 53 year-old  African American female who presented with dysphagia. Computed tomography of the  chest and esophagram confirmed esophageal lipoma as the cause of the patient’s symptoms. Accurately diagnosing an esophageal lipoma is crucial in order to rule  out potential malignant lesions, relieve patient symptoms and plan the appropriate treatment.

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[738]

TÍTULO / TITLE:  - Recurrent dermatofibrosarcoma protuberans: A continuing problem.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian Dermatol Online J. 2013 Jan;4(1):68-9. doi: 10.4103/2229-5178.105496.

            ●● Enlace al texto completo (gratuito o de pago) 4103/2229-5178.105496

AUTORES / AUTHORS:  - Makkar M; Singh DP; Rana A; Madan M

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, MMIMSR, Mullana, Ambala, Haryana, India.

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[739]

TÍTULO / TITLE:  - Nationwide registry-based analysis of cancer clustering detects strong familial occurrence of Kaposi sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e55209. doi: 10.1371/journal.pone.0055209. Epub 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0055209

AUTORES / AUTHORS:  - Kaasinen E; Aavikko M; Vahteristo P; Patama T; Li Y; Saarinen S; Kilpivaara O; Pitkanen E; Knekt P; Laaksonen M; Artama M; Lehtonen R; Aaltonen LA; Pukkala E

INSTITUCIÓN / INSTITUTION:  - Genome-Scale Biology Research Program, and Department of Medical Genetics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

RESUMEN / SUMMARY:  - Many cancer predisposition syndromes are rare or have incomplete penetrance, and  traditional epidemiological tools are not well suited for their detection. Here we have used an approach that employs the entire population based data in the Finnish Cancer Registry (FCR) for analyzing familial aggregation of all types of  cancer, in order to find evidence for previously unrecognized cancer susceptibility conditions. We performed a systematic clustering of 878,593 patients in FCR based on family name at birth, municipality of birth, and tumor type, diagnosed between years 1952 and 2011. We also estimated the familial occurrence of the tumor types using cluster score that reflects the proportion of patients belonging to the most significant clusters compared to all patients in Finland. The clustering effort identified 25,910 birth name-municipality based clusters representing 183 different tumor types characterized by topography and morphology. We produced information about familial occurrence of hundreds of tumor types, and many of the tumor types with high cluster score represented known cancer syndromes. Unexpectedly, Kaposi sarcoma (KS) also produced a very high score (cluster score 1.91, p-value <0.0001). We verified from population records that many of the KS patients forming the clusters were indeed close relatives, and identified one family with five affected individuals in two generations and several families with two first degree relatives. Our approach is unique in enabling systematic examination of a national epidemiological database  to derive evidence of aberrant familial aggregation of all tumor types, both common and rare. It allowed effortless identification of families displaying features of both known as well as potentially novel cancer predisposition conditions, including striking familial aggregation of KS. Further work with high-throughput methods should elucidate the molecular basis of the potentially novel predisposition conditions found in this study.

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[740]

TÍTULO / TITLE:  - FOXM1 is an oncogenic mediator in Ewing Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e54556. doi: 10.1371/journal.pone.0054556. Epub 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0054556

AUTORES / AUTHORS:  - Christensen L; Joo J; Lee S; Wai D; Triche TJ; May WA

INSTITUCIÓN / INSTITUTION:  - Division of Hematology-Oncology, Department of Pediatrics, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

RESUMEN / SUMMARY:  - Ewing Family Tumors (Ewing Sarcoma and peripheral Primitive Neuroectodermal Tumor) are common bone and soft tissue malignancies of childhood, adolescence and young adulthood. Chromosomal translocation in these tumors produces fusion oncogenes of the EWS/ETS class, with EWS/FLI1 being by far the most common. EWS/ETS chimera are the only well established driver mutations in these tumors and they function as aberrant transcription factors. Understanding the downstream genes whose expression is modified has been a central approach to the study of these tumors. FOXM1 is a proliferation associated transcription factor which has  increasingly been found to play a role in the pathogenesis of a wide range of human cancers. Here we demonstrate that FOXM1 is expressed in Ewing primary tumors and cell lines. Reduction in FOXM1 expression in Ewing cell lines results  in diminished potential for anchorage independent growth. FOXM1 expression is enhanced by EWS/FLI1, though, unlike other tumor systems, it is not driven by expression of the EWS/FLI1 target GLI1. Thiostrepton is a compound known to inhibit FOXM1 by direct binding. We show that Thiostrepton diminishes FOXM1 expression in Ewing cell lines and this reduction reduces cell viability through  an apoptotic mechanism. FOXM1 is involved in Ewing tumor pathogenesis and may prove to be a useful therapeutic target in Ewing tumors.

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[741]

TÍTULO / TITLE:  - To the editor: Is this cutaneous angiomyolipoma truly an angiomyolipoma?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian Dermatol Online J. 2013 Jan;4(1):65. doi: 10.4103/2229-5178.105495.

            ●● Enlace al texto completo (gratuito o de pago) 4103/2229-5178.105495

AUTORES / AUTHORS:  - Okon K; Dyduch G

INSTITUCIÓN / INSTITUTION:  - Department of Clinical and Experimental Pathomorphology, Jagiellonian University, Medical College, Krakow, Poland.

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[742]

TÍTULO / TITLE:  - Effects of titanium surface anodization with CaP incorporation on human osteoblastic response.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mater Sci Eng C Mater Biol Appl. 2013 May 1;33(4):1958-62. doi: 10.1016/j.msec.2013.01.002. Epub 2013 Jan 11.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.msec.2013.01.002

AUTORES / AUTHORS:  - Oliveira NC; Moura CC; Zanetta-Barbosa D; Mendonca DB; Cooper L; Mendonca G; Dechichi P

INSTITUCIÓN / INSTITUTION:  - Biomaterials and Cellular Biomimicry Laboratory, School of Dentistry, Federal University of Uberlandia, MG, Brazil.

RESUMEN / SUMMARY:  - In this study we investigated whether anodization with calcium phosphate (CaP) incorporation (Vulcano®) enhances growth factors’ secretion, osteoblast-specific gene expression, and cell viability, when compared to acid etched surfaces (Porous®) and machined surfaces (Screw®) after 3 and 7days. Results showed significant cell viability for Porous and Vulcano at day 7, when compared with Screw (p=0.005). At the same time point, significant differences regarding runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and bone sialoprotein (BSP) expression were found for all surfaces (p<0.05), but  with greater fold induction for Porous and Vulcano. The secretion of transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2) was not  significantly affected by surface treatment in any experimental time (p>0.05). Although no significant correlation was found for growth factors’ secretion and Runx2 expression, a significant positive correlation between this gene and ALP/BSP expression showed that their strong association is independent on the type of surface. The incorporation of CaP affected the biological parameters evaluated similar to surfaces just acid etched. The results presented here support the observations that roughness also may play an important role in determining cell response.

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[743]

TÍTULO / TITLE:  - Caruncular neurofibroma not associated with neurofibromatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Feb 21;2013. pii: bcr2012007764. doi: 10.1136/bcr-2012-007764.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007764

AUTORES / AUTHORS:  - Twaij S; Shafi A; Marshall T; Jabir M

INSTITUCIÓN / INSTITUTION:  - Department of Ophthalmology, Royal Victoria Hospitals, Belfast, UK.

RESUMEN / SUMMARY:  - A rare case of caruncular neurofibroma in a patient who did not have neurofibromatosis. To remember peripheral nerve sheath tumours in the differential diagnosis of caruncular lesions. Excisional biopsy proved to be adequate treatment in our case.

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[744]

TÍTULO / TITLE:  - Anomalous ovarian artery vascularisation of a large uterine fibroid: successful embolisation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 29;2013. pii: bcr2012008106. doi: 10.1136/bcr-2012-008106.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-008106

AUTORES / AUTHORS:  - Riu P; Vallone C; Rigon G; Signore F

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology, Hospital San Camillo-Forlanini, Rome, Italy.

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[745]

TÍTULO / TITLE:  - Hereditary gingival fibromatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Indian Soc Periodontol. 2012 Oct;16(4):606-9. doi: 10.4103/0972-124X.106930.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0972-124X.106930

AUTORES / AUTHORS:  - Dhadse PV; Yeltiwar RK; Pandilwar PK; Gosavi SR

INSTITUCIÓN / INSTITUTION:  - Department of Periodontics, Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India.

RESUMEN / SUMMARY:  - Hereditary gingival fibromatosis is a rare benign oral condition characterised by slow and progressive enlargement of both maxillary and mandibular attached gingiva. It may develop as an isolated disorder but can feature along with a syndrome. A case of 12 year old female child who presented with generalised severe gingival overgrowth, involving both the arches and covering almost the entire dentition, and had all the teeth remaining invisible within the confinement of gingival tissues. The excess gingival tissue, in this non-syndromic case was removed by conventional gingivectomy using local as well as general anaesthesia. The post-operative result was uneventful and the patient  appearance improved considerably. Good aesthetic result was achieved to allow patient to practice oral hygiene measures. After treatment regular recall visits  are necessary in order to evaluate oral hygiene and stability of periodontal treatment.

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[746]

TÍTULO / TITLE:  - Follicular dendritic cell sarcoma of the tonsil.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 29;2013. pii: bcr2012007440. doi: 10.1136/bcr-2012-007440.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007440

AUTORES / AUTHORS:  - Kara T; Serinsoz E; Arpaci RB; Vayisoglu Y

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Mersin University, School of Medicine, Mersin, Turkey.

RESUMEN / SUMMARY:  - Follicular dendritic cell sarcoma (FDCS) is an uncommon tumour within the spectrum of histiocytic and dendritic cell neoplasms that can occur at nodal and  extra-nodal sites. Besides being rare, these tumours are difficult to diagnose. A 72-year-old man with a painless mass in the right tonsil was admitted to the Mersin University Hospital. Tonsillectomy was performed. Microscopically, the tumour consisted of spindle-shaped cells with large oval to polygonal nuclei. Lymphocytes were scattered among the tumour cells. Immunohistochemically, the cells were positive for CD23 and vimentin. The tumour was diagnosed as FDCS with  histological and immunohistochemical findings. Recognition of extranodal FDCS requires knowledge of this entity and to consider it during the diagnosis. Confirmatory immunohistochemical staining is essential for diagnosis. Correct characterisation of this neoplasm is important because of its potential for recurrence and metastasis.

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[747]

TÍTULO / TITLE:  - Myopericytoma of the facial cheek.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Dermatol. 2013 Feb;25(1):122-4. doi: 10.5021/ad.2013.25.1.122. Epub 2013 Feb  14.

            ●● Enlace al texto completo (gratuito o de pago) 5021/ad.2013.25.1.122

AUTORES / AUTHORS:  - Kim EK; Lee JH; Kim SY; Kim GM

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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[748]

TÍTULO / TITLE:  - Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Cancer Res. 2013 Jan 30.

            ●● Enlace al texto completo (gratuito o de pago) 1158/1541-7786.MCR-12-0572

AUTORES / AUTHORS:  - Daft PG; Yuan K; Warram JM; Klein MJ; Siegal GP; Zayzafoon M

INSTITUCIÓN / INSTITUTION:  - University of Alabama at Birmingham.

RESUMEN / SUMMARY:  - Osteosarcoma is among the most frequently occurring primary bone tumors, primarily affecting adolescents and young adults. Despite improvements in osteosarcoma treatment, more specific molecular targets are needed as potential therapeutic options. One target of interest is alpha-Ca2+/calmodulin-dependent protein kinase II (alpha-CaMKII), a ubiquitous mediator of Ca2+-linked signaling, which has been shown to regulate tumor cell proliferation and differentiation. Here, we investigate the role of alpha-CaMKII in the growth and tumorigenicity of human osteosarcoma. We show that alpha-CaMKII is highly expressed in primary osteosarcoma tissue derived from 114 patients and is expressed in varying levels  in different human osteosarcoma cell lines (HOS, MG-63, MNNG/HOS and 143B). To examine whether alpha-CaMKII regulates osteosarcoma tumorigenic properties, we genetically inhibited alpha-CaMKII in two osteosarcoma cell lines using two different alpha-CaMKII shRNAs delivered by lentiviral vectors and overexpressed alpha-CaMKII by retrovirus. The genetic deletion of alpha-CaMKII by shRNA in MG-63 and 143B cells resulted in decreased proliferation (50 and 41%), migration  (22 and 25%) and invasion (95 and 90%), respectively. The overexpression of alpha-CaMKII in HOS cells resulted in increased proliferation (240%), migration (640%) and invasion (10,000%). Furthermore, alpha-CaMKII deletion in MG-63 cells  significantly reduced tumor burden in vivo (65%), while alpha-CaMKII overexpression resulted in tumor formation in a previously non-tumor forming osteosarcoma cell line (HOS). Our results suggest that alpha-CaMKII plays a critical role in determining the aggressive phenotype of osteosarcoma, and its inhibition could be an attractive therapeutic target to combat this devastating adolescent disease.

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[749]

TÍTULO / TITLE:  - Chordomas: what’s new?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World Neurosurg. 2013 Feb 1. pii: S1878-8750(13)00223-4. doi: 10.1016/j.wneu.2013.01.124.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.wneu.2013.01.124

AUTORES / AUTHORS:  - Tomasello F; Conti A

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, University of Messina, ITALY. Electronic address: ftomasel@unime.it.

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[750]

TÍTULO / TITLE:  - The Association between Subclinical Atherosclerosis and Uterine Fibroids.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(2):e57089. doi: 10.1371/journal.pone.0057089. Epub 2013 Feb 22.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0057089

AUTORES / AUTHORS:  - He Y; Zeng Q; Li X; Liu B; Wang P

INSTITUCIÓN / INSTITUTION:  - International Medical Center, Chinese People’s Liberation Army General Hospital,  Beijing, China ; Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China.

RESUMEN / SUMMARY:  - OBJECTIVES: To explore the atherogenic hypothesis of uterine fibroids among Chinese women. METHODS: In a case-control study, 335 patients confirmed by ultrasound or hysterectomy surgery and 539 controls were enrolled between October 1, 2009 and April 1, 2012. Unconditional logistic regressions were used to calculate the odds ratios (ORs) for the associations of subclinical atherogenic and cardiovascular risk parameters with uterine fibroids in the overall case group and hysterectomy-confirmed case group, respectively. RESULTS: Higher level  of ankle-brachial index (ABI) was independently associated with increased odds of uterine fibroids. The odds of UF among women in the highest tertile of ABI were 1.88 times higher (95%CI: 1.17, 3.02, Ptrend = 0.008) compared to those in the lowest tertile. The serum concentration of homocysteine was inversely related to  fibroids (middle vs. low: OR 0.56, 95%CI: 0.36, 0.85; high vs. low: OR 0.50, 95%  CI: 0.32, 0.79; Ptrend = 0.002). In the hysterectomy-confirmed group, an inverse  association was suggested between high-density lipoprotein cholesterol (HDL-C) and fibroids (OR 0.46, 95% CI: 0.25, 0.84, Ptrend = 0.014). Moreover, the effect  of homocysteine concentration was not observed in this group. CONCLUSIONS: These  findings suggest that women with uterine fibroids might have an increased risk of subclinical atherosclerosis.

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[751]

TÍTULO / TITLE:  - Extraskeletal osteosarcoma of the hand.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hand (N Y). 2012 Mar;7(1):124-6. doi: 10.1007/s11552-011-9371-3. Epub 2011 Nov 4.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11552-011-9371-3

AUTORES / AUTHORS:  - Tan KT; Idowu OK; Chandrasekar CR; Yin Q; Helliwell TR

INSTITUCIÓN / INSTITUTION:  - Royal Liverpool University Hospital Sarcoma Service, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Prescot Street, Liverpool, L7 8XP UK.

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[752]

TÍTULO / TITLE:  - Hemangiopericytoma/solitary fibrous tumor of pectoralis major muscle mimicking a  breast mass.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Case Rep. 2013;4(3):338-41. doi: 10.1016/j.ijscr.2013.01.013. Epub 2013 Jan 26.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2013.01.013

AUTORES / AUTHORS:  - Dragoumis D; Desiris K; Kyropoulou A; Malandri M; Assimaki A; Tsiftsoglou A

INSTITUCIÓN / INSTITUTION:  - St Luke’s Hospital, Department of General Surgery, Breast Division, Panorama, 55  236, Thessaloniki, Greece. Electronic address: ddragoumis@gmail.com.

RESUMEN / SUMMARY:  - INTRODUCTION: Hemangiopericytoma (HPC)/solitary fibrous tumor (SFT) is a very uncommon tumor of uncertain malignant behavior. In 1942, Stout and Murray first characterized these neoplasms as “vascular tumors arising from Zimmerman’s pericytes” and till now hemangiopericytomas and solitary fibrous tumors of the soft tissues are regarded as features of the same entity in the soft tissue fascicle. PRESENTATION OF CASE: We present a case of hemangiopericytoma/solitary  fibrous tumor of the pectoralis major muscle in a 33-year-old female. She first noticed a painless mass in her right breast. Ultrasound of the breast revealed a  large heterogeneously hypoechoic lesion within the pectoralis major muscle. Fine  needle aspiration of the tumor did not produce any meaningful result. The lesion  was completely removed by surgical resection. Histologically, the tumor had staghorn-like vasculature and immunohistochemistry for CD34 was positive, whereas desmin, smooth-muscle actin, S-100 protein, cytokeratins (AE1/AE3) and epithelial membrane antigen (EMA) were all negative. A diagnosis of hemangiopericytoma/solitary fibrous tumor was rendered. DISCUSSION: Tumors comprising the HPC/SFT spectrum represent a small subset of soft tissue sarcomas  and are found virtually at any site in the body. Wide surgical resection can achieve favorable long-term survival. CONCLUSION: Due to the rarity and unpredictable biological potential of these tumors, long-term follow-up is mandatory even after radical resection, because recurrence or development of metastasis may be delayed many years.

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[753]

TÍTULO / TITLE:  - Adrenal myelolipoma-a management dilemma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2012 Mar;3(1):33-5. doi: 10.1007/s13193-011-0117-z. Epub 2011 Dec 29.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-011-0117-z

AUTORES / AUTHORS:  - Jaiswal P; Saida NK; Sen A

INSTITUCIÓN / INSTITUTION:  - Command Hospital, Air force Bangalore, Bangalore, India ; 223/9 Golden jubilee complex, Air Force Officer Colony, Agram post, Bangalore-7, India.

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[754]

TÍTULO / TITLE:  - Multiple carcinosarcomas of the esophagus and stomach.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Mar;5(3):1017-1021. Epub 2012 Dec 28.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1095

AUTORES / AUTHORS:  - Xu F; Zou WB; Li XP; Xu YM; Qi XF; Hu LH; Li ZS; Yao DK

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, Yinzhou People’s Hospital, Ningbo, Zhejiang 315040;

RESUMEN / SUMMARY:  - Carcinosarcoma is an uncommon biphasic malignant neoplasm consisting of both carcinomatous and sarcomatous components. We report a case of an 84-year-old male with multiple carcinosarcomas occurring in the esophagus and stomach. Endoscopically, a bulky pedunculated polypoid lesion was observed in the middle of the esophagus and a huge discoid lesion in the lesser curvature. The patient received esophageal endoscopic mucosal resection, and the specimen measured 4x2.5x1.5 cm. Microscopically, the esophageal tumor consisted of several polymorphic spindle cells mixed with squamous cells, while the gastric biopsies revealed carcinomatous cells with evident abnormal karyokinesis and polymorphous  spindle cells. Immunohistochemically, the resected tumor stained positively for the epithelial markers, epithelial membrane antigen (EMA) and cytokeratin 19 (CK  19), and the mesenchymal markers, smooth muscle actin (SMA) and vimentin. The gastric lesion stained positively for CK AE1/AE3, actin and vimentin, but was negative for EMA. Both lesions were positive for neuron specific enolase (NSE), demonstrating neuroendocrine differentiation. The patient succumbed seven months  after being discharged from hospital. To our knowledge, this is the first case in the literature that describes multiple carcinosarcomas arising from the esophagus and stomach. A review of the available literature is also presented.

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[755]

TÍTULO / TITLE:  - Primary monophasic synovial sarcoma of the pancreas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Visc Surg. 2013 Mar 11. pii: S1878-7886(13)00007-6. doi: 10.1016/j.jviscsurg.2013.01.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jviscsurg.2013.01.006

AUTORES / AUTHORS:  - Luc G; Collet D; Reich S; Stanislas S; Sa-Cunha A

INSTITUCIÓN / INSTITUTION:  - Service de chirurgie digestive et coelioscopique, avenue de Magellan, 33604 Pessac cedex, France. Electronic address: guillaume.luc33@yahoo.fr.

RESUMEN / SUMMARY:  - We report a case of synovial sarcoma of the pancreas in a 44-year-old male who presented with multiple episodes of retroperitoneal hemorrhage; the diagnosis was confirmed by histology. The patient underwent distal pancreatectomy without complication, and the hospital stay was nine days. No adjuvant treatment was administered. The patient is alive at 1 year.

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