#15#
Revisiones (todas) *** Reviews (all)
Connective and Soft Tissue Tumors.
December 2012 - January 2013
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[1]
TÍTULO / TITLE: - Cyclophosphamide versus ifosfamide for paediatric and young adult bone and soft tissue sarcoma patients.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Cochrane Database Syst Rev. 2012 Dec 12;12:CD006300. doi: 10.1002/14651858.CD006300.pub3.
●● Enlace al texto completo (gratuito o de pago) 1002/14651858.CD006300.pub3
AUTORES / AUTHORS: - Mulder RL; Paulides M; Langer T; Kremer LC; van Dalen EC
INSTITUCIÓN / INSTITUTION: - Department of Paediatric Oncology, Emma Children’s Hospital / Academic Medical Center, Amsterdam, Netherlands. r.l.mulder@amc.uva.nl.
RESUMEN / SUMMARY: - BACKGROUND: Alkylating agents, such as cyclophosphamide and ifosfamide, play a major role in the improved survival of children and young adults with bone and soft tissue sarcoma. However, there is still controversy as to their comparative anti-tumour efficacy and possible adverse effects. This is an update of the first systematic review evaluating the state of evidence on the effectiveness of cyclophosphamide as compared to ifosfamide for paediatric and young adult patients with sarcoma. OBJECTIVES: To compare the possible effectiveness of cyclophosphamide with that of ifosfamide for paediatric and young adult patients with sarcoma. SEARCH METHODS: We searched CENTRAL (The Cochrane Library 2012, issue 2), MEDLINE/PubMed (from 1966 to March 2012) and EMBASE/Ovid (from 1980 to March 2012) with pre-specified terms. In addition, we searched reference lists of relevant articles, conference proceedings and ongoing trial databases (www.controlled-trials.com; searched April 2012). SELECTION CRITERIA: Randomised controlled trials (RCTs) or controlled clinical trials (CCTs) comparing cyclophosphamide and ifosfamide for the treatment of different types of sarcoma in paediatric and young adult patients (aged less than 30 years at diagnosis). Chemotherapy other than either cyclophosphamide or ifosfamide should have been the same in both treatment groups. DATA COLLECTION AND ANALYSIS: Two authors independently performed the study selection. MAIN RESULTS: No studies meeting the inclusion criteria of the review were identified. AUTHORS’ CONCLUSIONS: No RCTs or CCTs comparing the effectiveness of cyclophosphamide and ifosfamide in the treatment of bone and soft tissue sarcoma in children and young adults were identified. Therefore no definitive conclusions can be made about the effects of cyclophosphamide and ifosfamide in these patients. Based on the currently available evidence we are not able to give recommendations for clinical practice. More high quality research is needed.
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[2]
TÍTULO / TITLE: - The SSG XVIII/AIO Trial: Results Change the Current Adjuvant Treatment Recommendations for Gastrointestinal Stromal Tumors.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Am J Clin Oncol. 2013 Feb;36(1):89-90. doi: 10.1097/COC.0b013e31827a7f55.
●● Enlace al texto completo (gratuito o de pago) 1097/COC.0b013e31827a7f55
AUTORES / AUTHORS: - Eisenberg BL
INSTITUCIÓN / INSTITUTION: - Department of Surgery, Section of Surgical Oncology, Geisel School of Medicine at Dartmouth Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, LH.
RESUMEN / SUMMARY: - Although adjuvant imatinib (IM) for high risk GIST is an accepted treatment consideration, the duration of therapy remains controversial. The recently published SSGXVIII/AIO randomized clinical trial of 3 years vs. 1 year of adjuvant IM has established a benefit of RFS and OS for the 3 year cohort. Future studies are necessary to continue to further delineate risk variables for GIST recurrence.
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[3]
TÍTULO / TITLE: - Percutaneous computed tomography-guided resection of non-spinal osteoid osteomas in 54 patients and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Arch Orthop Trauma Surg. 2013 Jan 25.
●● Enlace al texto completo (gratuito o de pago) 1007/s00402-013-1686-9
AUTORES / AUTHORS: - Reverte-Vinaixa MM; Velez R; Alvarez S; Rivas A; Perez M
INSTITUCIÓN / INSTITUTION: - Departament de Cirugia Ortopedica y Traumatologia, Hospital Universitari Vall d’Hebron, Passeig de la Vall d’Hebron 119-129, 08035, Barcelona, España, merce83@hotmail.com.
RESUMEN / SUMMARY: - BACKGROUND: Osteoid osteoma is a benign osteoblastic tumor with a nidus of <20 mm in maximum diameter. There are several treatment options, all of them aiming either to resect or to eliminate the nidus. PURPOSE: To report and to describe the benefits of treating non-spinal osteoid osteoma by percutaneous computed tomography-guided resection, according to our experience. STUDY DESIGN: Retrospective case series METHODS: Between 1992 and 2008, 54 patients with non-spinal osteoid osteoma underwent primary treatment with percutaneous CT-guided resection. In all cases, the materials obtained were processed for pathology and microbiology. RESULTS: Fifty-four patients with a mean age of 22.7 years (range 10-47), of whom 46 were males (85.2 %) and 8 were females (14.8 %). The lesion size ranged between 5 and 15 mm with an average size of 6.9 mm. The resection was considered complete by the CT study in all 54 cases. Of all the specimens sent to pathology, the histological diagnosis was achieved in 41 (75.9 %). Cure was obtained in 50 patients (92.6 %) and the other four patients required a second surgery using the same technique, after which all of them achieved clinical and radiological improvement (100 %). CONCLUSION: Percutaneous computed tomography-guided resection of non-spinal osteoid osteomas provides good results, similar to other surgical techniques, with the advantages of being a simple, mini invasive, safe and economic procedure without the need for specific materials. Level of evidence, IV.
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[4]
TÍTULO / TITLE: - Outcomes of isolated limb perfusion in the treatment of extremity soft tissue sarcoma: A systematic review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Eur J Surg Oncol. 2013 Jan 22. pii: S0748-7983(12)01377-7. doi: 10.1016/j.ejso.2012.12.018.
●● Enlace al texto completo (gratuito o de pago) 1016/j.ejso.2012.12.018
AUTORES / AUTHORS: - Bhangu A; Broom L; Nepogodiev D; Gourevitch D; Desai A
INSTITUCIÓN / INSTITUTION: - Midlands Abdominal and Retroperitoneal Sarcoma Unit, The Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK.
RESUMEN / SUMMARY: - BACKGROUND: Isolated limb perfusion (ILP) may provide a limb salvage option for locally advanced soft tissue sarcoma (STS) not amenable to local resection. METHODS: A systematic review was performed for studies reporting outcome of ILP for locally advanced STS performed after 1980 in patients aged >/=12 years old. The main endpoints were tumour response and limb salvage rates. Complication and recurrence rates were secondary endpoints. RESULTS: Eighteen studies were included, providing outcomes for 1030 patients. Tumour necrosis factor-alpha with melphalan was the commonest chemotherapy regime. When reported, 22% of cases achieved a complete tumour response (216/964, 15 studies) with an overall response rate of 72% (660/911, 15 studies). At median follow-up times ranging between 11 and 125 months, the limb salvage rate was 81% in patients who otherwise would have been subjected to amputation. However, 27% of patients suffered local recurrence and 40% suffered distant failure. ILP was associated with severe locoregional reactions in 4% (22/603) of patients. Amputation due to complications within 30 days was necessary in 1.2% of cases (7/586, nine studies). There was insufficient evidence to determine the effect of ILP on survival. CONCLUSION: ILP induces a high tumour response rate, leads to a high limb salvage rate but is associated with a high recurrence rate. It provides a limb salvage alternative to amputation when local control is necessary.
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[5]
TÍTULO / TITLE: - Primary spinal chondrosarcoma: radiological manifestations with histopathological correlation in eight patients and literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Clin Imaging. 2013 Jan-Feb;37(1):124-33. doi: 10.1016/j.clinimag.2012.02.010. Epub 2012 Jun 8.
●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.02.010
AUTORES / AUTHORS: - Liu G; Wu G; Ghimire P; Pang H; Zhang Z
INSTITUCIÓN / INSTITUTION: - Department of Magnetic Resonance Imaging, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China. liuguobing123@yahoo.com.cn
RESUMEN / SUMMARY: - PURPOSE: The aim of this study was to delineate radiological-pathological correlation in primary vertebral chondrosarcoma. METHODS: Eight histopathologically confirmed cases were analyzed for pathological and radiological characteristics. RESULTS: Magnetic resonance images of three conventional and one clear cell cases showed lobulated or irregular masses with line or septa enhancement. Two conventional lesions showed signal intensity of high water content on T2-weighted images, in which aneurismal bone cysts were confirmed. The myxoid lesion showed a relatively diffuse signal and enhancement. Marked masses were found in the two mesenchymal patients, either dumbbell-like or round-like. CONCLUSION: Primary spinal chondrosarcomas have certain radiological findings that may correlate to the pathological subtypes.
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[6]
TÍTULO / TITLE: - Atypical lipomatous tumor mimicking giant fibrovascular polyp of the esophagus: report of a case and a critical review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Hum Pathol. 2013 Jan 24. pii: S0046-8177(12)00421-2. doi: 10.1016/j.humpath.2012.10.023.
●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.10.023
AUTORES / AUTHORS: - Boni A; Lisovsky M; Cin PD; Rosenberg AE; Srivastava A
INSTITUCIÓN / INSTITUTION: - Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, NH.
RESUMEN / SUMMARY: - An 81-year-old man presented to the emergency department with a mass protruding from his mouth after an episode of emesis. A computed tomography scan showed a hypodense, polypoid structure with a fatty component. The long polyp was attached by a narrow stalk to the cervical esophagus. A 14.0-cm slender mass resembling a giant fibrovascular polyp (GFP) of the esophagus was resected. The microscopic, immunohistochemical, and molecular findings were, however, those of an atypical lipomatous tumor (ALT). Atypical lipomatous tumor of the esophagus is a rare, low-grade malignant neoplasm, with a potential for local recurrence and, in most instances, presents as a large intraluminal polyp mimicking a GFP. Cases reported in the literature as primary myxoid liposarcomas of the esophagus are in all likelihood examples of ALT with myxoid change. A recent case reported as a GFP with karyotypic abnormalities on comparative genomic hybridization is also most likely to be an ALT mimicking a GFP. Pathologists need to be aware of the pitfalls in the diagnosis of ALT of the esophagus and should carefully evaluate the adipocytic component of these lesions.
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[7]
TÍTULO / TITLE: - Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma: case report and literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Hum Pathol. 2013 Jan 25. pii: S0046-8177(12)00424-8. doi: 10.1016/j.humpath.2012.11.002.
●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.11.002
AUTORES / AUTHORS: - Wu W; Tanrivermis Sayit A; Vinters HV; Pope W; Misradraei L; Said J
INSTITUCIÓN / INSTITUTION: - Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1732. Electronic address: winniewu@mednet.ucla.edu.
RESUMEN / SUMMARY: - Histiocytic sarcoma (HS) is a rare neoplasm that occurs most commonly in the intestinal tract, skin, soft tissue, and lymph node. The incidence of primary central nervous system (CNS) HS is even rarer, with a total of 6 cases reported in the literature. An etiologic link has not been identified for CNS HS, and the current case of primary CNS HS is unique in that an etiologic link to prior radiation therapy is identified, associated with complex cytogenetic abnormalities in the tumor. Although radiation-associated sarcomas can present as any number of different pathologic entities, this is the first reported case of a radiation-associated CNS HS. The pathologic and immunophenotypic characteristics of this case, with a nearly obscuring heavy inflammatory infiltrate and expression of monocytic/histiocytic markers (CD163, CD68, CD4, fascin), are characteristic of CNS HS. A discussion of the differential diagnosis and review of relevant literature are presented.
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[8]
TÍTULO / TITLE: - Renal epithelioid angiomyolipoma: imaging characteristics in nine cases with radiologic-pathologic correlation and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - AJR Am J Roentgenol. 2013 Feb;200(2):W178-86. doi: 10.2214/AJR.12.8776.
●● Enlace al texto completo (gratuito o de pago) 2214/AJR.12.8776
AUTORES / AUTHORS: - Froemming AT; Boland J; Cheville J; Takahashi N; Kawashima A
INSTITUCIÓN / INSTITUTION: - Department of Radiology, Mayo Clinic, 200 1st St SE, Rochester, MN 55905.
RESUMEN / SUMMARY: - OBJECTIVE: The purpose of this study was to describe the imaging features of renal epithelioid angiomyolipoma (EAML), a rare subtype of angiomyolipoma, with clinical and pathologic correlation. MATERIALS AND METHODS: This study was a retrospective review of nine cases from a single institution in which total resection and preoperative imaging were performed and the diagnosis of EAML was made. Imaging included CT (nine cases), MRI (five cases), and ultrasound (one case), and the images were reviewed in consensus by two radiologists. Patient demographics, disease associations, presentation, and outcomes were determined by chart review. RESULTS: The patients were nine women and one man (mean age, 42 years). Two patients had tuberous sclerosis complex. The size of the nine EAMLs ranged from 1.4 to 22 cm (mean, 7.8 cm). Six lesions had minor components of fat identifiable at imaging. The contrast enhancement pattern was heterogeneous in eight lesions, five of which contained cysts, necrosis, and hematoma. Four presentations were acute hemorrhage, with ruptured EAML in three of the four. Five tumors extended into the renal sinus. Two tumors were locally invasive. One patient had metastatic disease at presentation with epithelioid tumor identified in a single lymph node. The follow-up periods ranged from 0 to 89 months, and there was one case of suspected but not yet proved recurrence. CONCLUSION: Renal EAML can have a range of imaging appearances and can be indistinguishable from renal cell carcinoma and angiomyolipoma with minimal fat. EAML can be considered when a mass is found that has small foci of macroscopic fat without calcification or when acute hemorrhage of a renal mass occurs.
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[9]
TÍTULO / TITLE: - Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Semin Diagn Pathol. 2013 Feb;30(1):13-28. doi: 10.1053/j.semdp.2012.01.002.
●● Enlace al texto completo (gratuito o de pago) 1053/j.semdp.2012.01.002
AUTORES / AUTHORS: - Llombart B; Serra-Guillen C; Monteagudo C; Lopez Guerrero JA; Sanmartin O
INSTITUCIÓN / INSTITUTION: - Dermatology Department, Instituto Valenciano de Oncologia, Valencia, España. Electronic address: beatriz.llombart@uv.es.
RESUMEN / SUMMARY: - Dermatofibrosarcoma protuberans (DFSP) is a rare superficial tumor characterized by high rates of local recurrence and low risk of metastasis. DFSP occurs most commonly on the trunk and proximal extremities, affects all races, and often develops between the second and fifth decade of life. The tumor grows slowly, typically over years. Histologically, several variants of DFSP have been described and should be well characterized to avoid misdiagnosis with other tumors. These include pigmented (Bednar tumor), myxoid, myoid, granular cell, sclerotic, atrophic DFSP, giant cell fibroblastoma, and DFSP with fibrosarcomatous areas. Of all these variants, only the DFSP with fibrosarcomatous areas is high grade, with a higher rate of local recurrence and distant metastasis. DFSP is genetically characterized by the t(17;22)(q22;q13), resulting in the fusion of alpha chain type 1 of collagen gene and platelet-derived growth factor beta gene. This translocation is present in 90% of DFSP and represents a very useful tool in the differential diagnosis of DFSP with other tumors with similar histology. The standard treatment is wide local excision with at least a 2-cm margin. However, local recurrence after apparently adequate surgical excision is well recognized. Mohs micrographic surgery would be the treatment of choice with a better cure rate and maximal conservation of tissue. When surgery is insufficient, clinical evidence has suggested that imatinib mesylate is a safe and effective treatment in DFSP, especially in cases of local advanced or metastatic disease. This article presents an overview of the state of the art in the clinicopathological management of this disease.
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[10]
TÍTULO / TITLE: - Renal angiomyolipoma.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - BJU Int. 2012 Dec;110 Suppl 4:25-7. doi: 10.1111/j.1464-410X.2012.11618.x.
●● Enlace al texto completo (gratuito o de pago) 1111/j.1464-410X.2012.11618.x
AUTORES / AUTHORS: - Lienert AR; Nicol D
INSTITUCIÓN / INSTITUTION: - Department of Urology, Counties-Manukau DHB, Auckland, New Zealand. andrewlienert@hotmail.com
RESUMEN / SUMMARY: - * Renal angiomyolipomas (AMLs) are usually easy to diagnose with imaging alone. They have unique characteristics on ultrasonography, computerised tomography and magnetic resonance imaging that usually allow AMLs to be differentiated from other renal masses. * If this is not possible on imaging criteria then biopsy can be performed and AMLs have unique immunohistochemical staining that allows them to be accurately differentiated from other renal tumours.
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[11]
TÍTULO / TITLE: - Neurofibromatosis type 1, gastrointestinal stromal tumor, leiomyosarcoma and osteosarcoma: Four cases of rare tumors and a review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Crit Rev Oncol Hematol. 2012 Dec 3. pii: S1040-8428(12)00214-4. doi: 10.1016/j.critrevonc.2012.11.001.
●● Enlace al texto completo (gratuito o de pago) 1016/j.critrevonc.2012.11.001
AUTORES / AUTHORS: - Afsar CU; Kara IO; Kozat BK; Demiryurek H; Duman BB; Doran F
INSTITUCIÓN / INSTITUTION: - Cukurova University Medical Faculty, Department of Medical Oncology, Adana, Turkey. Electronic address: cigdemusul@yahoo.com.
RESUMEN / SUMMARY: - BACKGROUND: Neurofibromatosis type 1 (NF1) is a genetic syndrome that predisposes patients to benign and malignant tumor development. Patients with NF1 develop multiple neurofibromas that can transform into aggressive sarcomas known as malignant peripheral nerve sheath tumors. In contrast, malignant tumors unrelated to the nervous system rarely coexist with neurofibromatosis. The aim of this article was to present four cases of adult NF1 patients with malignant tumors unrelated to the nervous system as well as a bibliographic search for papers describing these tumors in NF1, focusing on osteosarcomas, gastrointestinal stromal tumors (GISTs), leiomyosarcomas and somatostatinomas and their genetic alterations in NF1. METHODS: Search engines such as PubMed and MEDLINE were browsed for English-language articles since 1989 using a list of keywords, as well as references from review articles. Search terms were NF1, osteosarcoma, leiomyosarcoma, somatostatinoma and GIST. Data were summarized in a table at the end of the Results section. RESULTS: In our four NF1 cases, there were one osteosarcoma, one leiomyosarcoma, one somatostatinoma and GIST and one GIST. NF1 was diagnosed at an adult age when these patients were admitted to our oncology department. The results generated by the literature search yielded 75 articles about NF and GIST. We summarized the clinical characteristics of 43 patients with NF1 and somatostatinoma. Forty-five articles involving NF and osteosarcoma were found, and of these, 26 involved NF1; from these articles, we identified the clinical features of 8 patients. Twenty-five articles were found concerning NF1 and leiomyosarcoma, and of those, we summarized the clinical features of 15 patients. CONCLUSIONS: Here we reviewed somatostatinomas, GISTs, osteosarcomas and leiomyosarcomas occurring in NF1 patients. Patients with NF1 who present with gastrointestinal symptoms, should be carefully evaluated carefully with a high index of suspicion of potential GISTs, periampullary and duodenal tumors. Patients with pathological fractures or bone pain along with NF1 should be carefully screened for malignant bone tumors. Patients with NF1 can develop leiomyosarcoma less frequently than other malignancies, but the association of uterine leiomyoma and NF1 may not be fortuitous. Somatic mutations were defined for frequent tumors, including neurogenic tumors and GISTs but not for sarcomas due to the complexity of underlying mechanisms of the disease and tumorigenesis. Based on the findings; all NF patients can develop malignant tumors, including the less frequently observed ones. Therefore, we recommend that new genetic studies should be performed for rare malignancies in cases of NF1.
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[12]
TÍTULO / TITLE: - Isolated limb perfusion of soft tissue sarcomas: A comprehensive review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Cancer Treat Rev. 2012 Dec 8. pii: S0305-7372(12)00212-5. doi: 10.1016/j.ctrv.2012.10.005.
●● Enlace al texto completo (gratuito o de pago) 1016/j.ctrv.2012.10.005
AUTORES / AUTHORS: - Seinen JM; Hoekstra HJ
INSTITUCIÓN / INSTITUTION: - Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
RESUMEN / SUMMARY: - Patients with primary irresectable, locally advanced soft tissue sarcomas of the limbs form a challenging group for the treating physician. Multimodality treatment is necessary to guarantee optimal limb salvage and survival rates. Since the introduction of isolated limb perfusion in the late fifties, several treatment regimens have been proposed. Isolated perfusion with melphalan and TNF-alpha, as part of a multimodality treatment, is regarded as the current best treatment option today. Ongoing studies are investigating potential benefit of other doses, new chemotherapeutic agents and new techniques in perfusion and radiotherapy. This article provides a historical overview of published literature and insight in upcoming treatment techniques.
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[13]
TÍTULO / TITLE: - Ossifying parosteal lipoma of the mandible: a case report and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Dentomaxillofac Radiol. 2013 Jan;42(1):20100331. doi: 10.1259/dmfr.20100331.
●● Enlace al texto completo (gratuito o de pago) 1259/dmfr.20100331
AUTORES / AUTHORS: - Sun Z; Sun L; Zhang Z; Ma X
INSTITUCIÓN / INSTITUTION: - Dr Lisha Sun, Department of Oral and Maxillofacial Pathology, School and Hospital of Stomatology, Peking University, 22 South Zhongguancun Avenue, Haidian District, Beijing 100081, China. E-mail: lisa_sun@bjmu.edu.cn.
RESUMEN / SUMMARY: - Parosteal lipoma is an unusual kind of lipoma and occurs in intimate association with the underlying periostium of the bone. Parosteal lipomas mostly affect the long bones and involvement of the mandible is rare. We report a case of ossifying parosteal lipoma of the mandible in which CT was effective in diagnosis and showed a well-circumscribed mass of fat attenuation containing areas of ossification and branch-like bony protuberances from adjacent cortical bone. Microscopic examination revealed that the mass was composed of mature fat cells without nuclear hyperchromasia or atypia. Layers of bone and ossification were found inside. Although rare, it should be considered as a differential diagnosis of teratoma, osteochondroma and osteosarcoma.
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[14]
TÍTULO / TITLE: - Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Pathol Int. 2012 Dec;62(12):817-22. doi: 10.1111/pin.12014.
●● Enlace al texto completo (gratuito o de pago) 1111/pin.12014
AUTORES / AUTHORS: - Matsukuma S; Hisaoka M; Obara K; Kono T; Takeo H; Sato K; Hata Y
INSTITUCIÓN / INSTITUTION: - Department of Pathology, Japan Self Defense Forces Central Hospital, Tokyo, Japan.
RESUMEN / SUMMARY: - Reported herein is an extremely rare case of primary pulmonary myxoid sarcoma (PPMS). A 31-year-old man presented with a 2.7 cm-sized pulmonary tumor surrounded by capsule-like fibrosis. The patient has been free of disease for 5.8 years after surgery. This tumor focally showed endobronchial features, and consisted of reticular cords of oval, short spindle, or polygonal cells with swollen vesicular nuclei accompanied by an abundant myxoid stroma, closely resembling extraskeletal myxoid chondrosarcoma. Tumor cells were diffusely positive for vimentin and focally positive for epithelial membrane antigen, but were negative for cytokeratin, TTF-1, Napsin A, S-100 protein, CD34, desmin, smooth-muscle actin, CD10, p63, calponin, h-caldesmon, c-kit, HMB-45, synaptophysin, or glial fibrillary acid protein. Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion. These findings indicate that the current tumor is an additional case of PPMS with EESR1-CREB1 fusion, recently reported by Thway et al. Some cases of PPMS can behave in an indolent manner.
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[15]
TÍTULO / TITLE: - Multifocal giant cell tumor of the tendon sheath: case report and literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Skeletal Radiol. 2013 Mar;42(3):447-50. doi: 10.1007/s00256-012-1552-9. Epub 2012 Dec 5.
●● Enlace al texto completo (gratuito o de pago) 1007/s00256-012-1552-9
AUTORES / AUTHORS: - Zeinstra JS; Kwee RM; Kavanagh EC; van Hemert WL; Adriaensen ME
INSTITUCIÓN / INSTITUTION: - Department of Radiology, Atrium Medical Center Parkstad, Henri Dunantstraat 5, 6419 PC, Heerlen, the Netherlands.
RESUMEN / SUMMARY: - In this study, we present the rare case of a patient with a multifocal giant cell tumor of the tendon sheath occurring at three different localizations along the same tendon. We review radiographic, ultrasonographic, and magnetic resonance imaging findings, and discuss previously reported cases.
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[16]
TÍTULO / TITLE: - Case report of bilateral adrenal leiomyoma with review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Pediatr Surg Int. 2013 Jan 26.
●● Enlace al texto completo (gratuito o de pago) 1007/s00383-013-3264-1
AUTORES / AUTHORS: - Parelkar SV; Sampat NP; Sanghvi BV; Joshi PB; Sahoo SK; Patel JL; Oak SN
INSTITUCIÓN / INSTITUTION: - Seth GSMC and King Edward VII memorial hospital, Mumbai, Maharashtra, India.
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[17]
TÍTULO / TITLE: - Epidural intracranial metastasis from benign leiomyoma: A case report with literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Clin Neurol Neurosurg. 2012 Nov 28. pii: S0303-8467(12)00562-8. doi: 10.1016/j.clineuro.2012.10.028.
●● Enlace al texto completo (gratuito o de pago) 1016/j.clineuro.2012.10.028
AUTORES / AUTHORS: - Joo HJ; Han SS; Kwon JT; Park ES; Jung YY; Kim HK
INSTITUCIÓN / INSTITUTION: - Department of Obstetrics and Gynecology, Chung-Ang University Hospital, 102, Heuksoek-ro, Dongjak-gu, Seoul, 156-755, Republic of Korea. Electronic address: hjjoo8041@gmail.com.
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[18]
TÍTULO / TITLE: - Aggressive deep angiomyxoma—a case report and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Eur J Gynaecol Oncol. 2012;33(6):658-61.
AUTORES / AUTHORS: - Kascak P; Zamecnik M
INSTITUCIÓN / INSTITUTION: - Faculty of Health, Alexander Dubcek University, Trencin, Slovak Republic. pkascak@gmail.com
RESUMEN / SUMMARY: - BACKGROUND: Aggressive deep angiomyxoma (AA) is locally infiltrative, non-metastasizing neoplasm that typically occurs in the pelvis and perineum in women of the reproductive age. Local recurrence is high despite apparently complete surgical resection. CASE: The authors describe a case of AA in the pelvis in a 27-year-old woman. She underwent one invasive diagnostic procedure and three surgical interventions during four months, due to diagnostic problems and very early recurrence of the disease. Follow-up one year later revealed no recurrence. CONCLUSION: The present case confirms that AA are locally aggressive and notorious for local recurrence. Such an early recurrence of AA has not been described in available literature.
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[19]
TÍTULO / TITLE: - Epstein-Barr virus (EBV)-related smooth muscle tumors of central nervous system-a report of two cases and review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Clin Imaging. 2012 Dec 21. pii: S0899-7071(12)00288-4. doi: 10.1016/j.clinimag.2012.09.019.
●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.09.019
AUTORES / AUTHORS: - Lohan R; Bathla G; Gupta S; Hegde AN
INSTITUCIÓN / INSTITUTION: - Department of Radiology, National University Hospital, 5 Lower, Kent Ridge road, Singapore.
RESUMEN / SUMMARY: - Epstein-Barr virus-related smooth muscle cell tumors (EBV-SMTs) are rare albeit increasingly recognized tumors in immunocompromised patients. We report on the imaging features of EBV-SMTs occurring in the central nervous system (CNS) in two patients. Central areas of T2 prolongation, surrounding vasogenic edema, mass effect on adjacent neuroparenchyma, dural tails, and underlying bone erosions were the notable imaging findings. Besides the usual differentials of extraaxial tumors like meningioma, hemangiopericytoma, and lymphoma, CNS EBV-SMTs should be considered in immunocompromised patients.
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[20]
TÍTULO / TITLE: - Progressive bilateral lipoma arborescens of the knee complicated by juvenile spondyloarthropathy: A case report and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Semin Arthritis Rheum. 2013 Jan 24. pii: S0049-0172(12)00304-6. doi: 10.1016/j.semarthrit.2012.12.022.
●● Enlace al texto completo (gratuito o de pago) 1016/j.semarthrit.2012.12.022
AUTORES / AUTHORS: - Xue J; Alario AJ; Nelson SD; Wu H
INSTITUCIÓN / INSTITUTION: - Department of Rheumatology, Second Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, P.R. China.
RESUMEN / SUMMARY: - OBJECTIVES: To report an unusual case of lipoma aborescens (LA) presented in a patient with treatment-responsive juvenile spondyloarthropathy (JSPA) and to summarize the clinical manifestations, therapy and prognosis of LA by literature review. METHODS: We report an atypical case of a 17-year-old patient with an initial presentation of juvenile spondyloarthropathy, whose inflammatory condition was improved successfully by traditional anti-rheumatic drugs and an anti-TNF alpha agent but developed progressive swelling of bilateral knees. Lipoma arborescens were diagnosed in each knee by synovial biopsy obtained by arthroscopic surgery. Fifty-one cases of LA have been reported and are reviewed in detail. RESULTS: Clinically, LA could present as monoarthritis or oligoarthritis. The lateral compartment of the knee is the most common site of involvement. Several cases were reported as a comorbidity of inflammatory diseases, but were not improved by anti-inflammatory therapy. Most patients were diagnosed by classic MRI and biopsy findings. The lesions can be managed by open or arthroscopic surgery, but a minority of the cases may have reoccurrence in the same or opposite joint. CONCLUSIONS: LA is a very rare lesion of the synovial and bursal tissue with an unknown etiology. It is considered to be a benign proliferation of the synovial fat associated with trauma, degenerative or inflammatory conditions. LA should be considered as a secondary or comorbid condition in inflammatory arthropathies if other joints respond well to intensive therapy and one or more do not.
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[21]
TÍTULO / TITLE: - Primary retroperitoneal mucinous cystadenoma with a sarcoma-like mural nodule: an immunohistochemical study with histogenetic considerations and literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Int J Gynecol Pathol. 2013 Jan;32(1):15-25. doi: 10.1097/PGP.0b013e31825f7c41.
●● Enlace al texto completo (gratuito o de pago) 1097/PGP.0b013e31825f7c41
AUTORES / AUTHORS: - Demirel D; Gun I; Kucukodaci Z; Balta AZ; Ramzy I
INSTITUCIÓN / INSTITUTION: - Department of Pathology, Gulhane Military Medical Academy, Turkey. demireldilaver@yahoo.com
RESUMEN / SUMMARY: - Primary retroperitoneal mucinous cystadenomas (PRMCs) are extremely rare tumors and their association with sarcoma-like mural nodules (SLMNs) has not been described thoroughly. The aim of this study is to characterize the gross and microscopic features and the immunohistochemical profile of the first case of PRMC with SLMN and to discuss the differential diagnosis of SLMNs. The literature related to primary retroperitoneal mucinous tumors is reviewed in an attempt to clarify the histogenesis of the epithelial and sarcomatoid components of the associated mural nodules. A 34-yr-old woman presented with a 14-cm retroperitoneal cystic lesion with a 6-cm mural nodule. An immunohistochemical study with a panel of 19 antibodies and a histochemical study for mucin stains were performed. The epithelial component of the PRMC showed positive staining for cytokeratin (CK) 7, CK AE1/3, epithelial membrane antigen, carcinoembryonic antigen, and calretinin. The neoplasm was not immunoreactive for CK 20, CK 5/6, and the other antibodies used in this study. In addition, it stained positively for mucin by mucicarmine, periodic acid-Schiff, and Alcian blue. The stromal cells of the cyst showed estrogen receptor positivity. SLMN cells were negative for all CKs and other epithelial markers used in the study, but they showed diffuse positive staining for vimentin and CD68, and positive staining for Ki-67 was demonstrated in 25% of these cells. The immunohistochemical and histochemical profiles of PRMC were similar to those of ovarian mucinous neoplasms and the mesothelium. The formation of SLMNs seems to be related to subepithelial hemorrhage and some reactive epithelial changes near the mural nodules. The specific immunohistochemical and morphologic features of SLMNs are helpful in differentiating them from malignant mural nodules, including true sarcomas, osteoclast-rich undifferentiated carcinomas, and carcinosarcomas. Such a differentiation is critical in view of its significant impact on the management of these neoplasms, particularly in young patients who desire to preserve their fertility.
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[22]
TÍTULO / TITLE: - Does body mass index at diagnosis or weight change during therapy predict toxicity or survival in intermediate risk rhabdomyosarcoma? A report from the Children’s Oncology Group soft tissue sarcoma committee.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Pediatr Blood Cancer. 2013 Jan 17. doi: 10.1002/pbc.24322.
●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24322
AUTORES / AUTHORS: - Burke ME; Lyden ER; Meza JL; Ladas EJ; Dasgupta R; Wiegner EA; Arndt CA
INSTITUCIÓN / INSTITUTION: - Division of Hematology/Oncology, Children’s Hospital of The King’s Daughters, Norfolk, Virginia. megan.burke@chkd.org.
RESUMEN / SUMMARY: - BACKGROUND: Weight loss prevalence and its impact on toxicities and survival in intermediate risk rhabdomyosarcoma (IRMS) patients are unknown. We evaluated the association between weight change during therapy and number of toxicities, hospital days, infections, and overall survival and between baseline body mass index (BMI) and survival in patients treated on Children’s Oncology Group trial D9803. PROCEDURE: Four hundred sixty-eight IRMS patients age >/=2 and <21 years treated on D9803 had required data. Regression models evaluated association between weight loss from baseline and toxicities, hospital days, infections, and survival. Kaplan-Meier curves and regression models evaluated baseline BMI percentile’s association with survival. RESULTS: Thirty-five percent and 37% of patients had >5% weight loss at 12 and 24 weeks, respectively, with 16% and 19% losing >10% weight respectively. Greater than 10% weight loss at 24 weeks was associated with more toxicities and hospital days during subsequent therapy but not infection rate or survival. Baseline underweight patients (<5th percentile BMI) had borderline inferior survival compared with baseline average weight patients while there was no difference in survival seen between average weight and overweight or obese patients. CONCLUSIONS: Nearly one in five IRMS patients experienced >10% weight loss on therapy. This was associated with increased toxicity but not decreased survival compared with patients who had less weight loss. Baseline BMI percentile trended toward a significant association with survival. Future studies might investigate nutritional impact on quality of life and if weight loss is preventable by early nutritional intervention. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
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[23]
TÍTULO / TITLE: - Extended Adjuvant Therapy with Imatinib in Patients with Gastrointestinal Stromal Tumors : Recommendations for Patient Selection, Risk Assessment, and Molecular Response Monitoring.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Mol Diagn Ther. 2013 Jan 26.
●● Enlace al texto completo (gratuito o de pago) 1007/s40291-013-0018-7
AUTORES / AUTHORS: - Rutkowski P; Przybyl J; Zdzienicki M
INSTITUCIÓN / INSTITUTION: - Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Roentgena 5, 02-781, Warsaw, Poland, rutkowskip@coi.waw.pl.
RESUMEN / SUMMARY: - On the basis of the recently published results of a clinical trial comparing 12 and 36 months of imatinib in adjuvant therapy for gastrointestinal stromal tumors (GISTs), which demonstrated clinical benefit of longer imatinib treatment in terms of delaying recurrences and improving overall survival, both the US Food and Drug Administration and the European Medicines Agency have updated their recommendations and approved 36 months of imatinib treatment in patients with v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT)-positive GISTs (also known as CD117-positive GISTs) at high risk of recurrence after surgical resection of a primary tumor. This article discusses patient selection criteria for extended adjuvant therapy with imatinib, different classifications of risk of recurrence, and assessment of the response to therapy.
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[24]
TÍTULO / TITLE: - A rare location of benign osteoblastoma: case study and a review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Eur Rev Med Pharmacol Sci. 2012 Nov;16(13):1891-4.
AUTORES / AUTHORS: - Caltabiano R; Serra A; Bonfiglio M; Platania N; Albanese V; Lanzafame S; Cocuzza S
INSTITUCIÓN / INSTITUTION: - Otolaryngology Section, Department of Medicine and Surgery, University of Catania, Italy. scocuzza@unict.it
RESUMEN / SUMMARY: - Osteoblastoma is a solitary, benign bone tumor that is rarely localized in the frontal sinus. It consists of hypocellular mineralized tissue that may form large masses or irregular trabeculae. A 31 year old man came to our attention with a 7 month history of diplopia, photophobia, frontal headhaches and progressive exophthalmos with proptosis of the left eye. The patient was submitted to computed tomography (CT) which allowed to appraise the extension of the lesion. The mass expanded inside the left frontal sinus and the upper ethmoidal cells invading the left orbital roof. Considering the extension of the tumor, the site and the connections with contiguous structures, a combination of endoscopic endonasal technique with intraorbital approach was performed. At histological examination typical features of benign osteoblastoma were observed. The sites of predilection for the tumor are the long bones, vertebral column, and small bones of hands and feet. Its occurrence in the skull and jaw bones is relatively rare and represents only 15% of all osteoblastomas. To our knowledge, only 5 cases of osteoblastoma of the frontal sinus have been previously reported in the English-language literature. This report describes a case of benign osteoblastoma in a rare site, namely, the frontal sinus with particular attention about the differential diagnosis and the treatment.
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[25]
TÍTULO / TITLE: - Synovial sarcoma in cerebellum: a case report and literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Brain Tumor Pathol. 2012 Dec 8.
●● Enlace al texto completo (gratuito o de pago) 1007/s10014-012-0126-9
AUTORES / AUTHORS: - Xiao GY; Pan BC; Tian XY; Li Y; Li B; Li Z
INSTITUCIÓN / INSTITUTION: - Department of Pathology, Tongjiang Hospital of Guangdong, Nanguo Road East, Shunde District, Foshan, 528300, China.
RESUMEN / SUMMARY: - Synovial sarcoma is a tumor of unknown origin and is extremely rare in the central nervous system. We present a case involving an unusual cerebellar synovial sarcoma in a male infant. Neuroimaging revealed a large, solid, gadolinium-enhancing mass located in the parenchyma of the right cerebellar hemisphere and associated with multiple cyst formation. Histologically, the tumor was composed of uniform spindle cells with indistinct borders and numerous mitotic figures. The tumor cells were observed to form dense cellular sheets, but in some areas the tumor showed a hemangiopericytomatous vascular pattern consisting of tumor cells arranged around dilated, thin-walled blood vessels. Immunohistochemistry showed that vimentin, CD99 and Bcl-2 were diffusely positive in most cells, and focal reactivity for cytokeratin (AE1/AE3) and S-100 protein was also observed. The tumor cells were, however, negative for CK19, EMA, CD34, synaptophysin, GFAP, desmin, myogenin, and smooth muscle actin. Cytogenetic analysis using fluorescence in situ hybridization demonstrated the translocation t(X;18)(p11;q11). A diagnosis of primary cerebellar monophasic synovial sarcoma was made. To our knowledge, this is the first report of a synovial sarcoma in brain parenchyma. The present case indicates that it is essential to select the appropriate immunohistochemical panel and-especially-perform molecular analysis to accurately diagnose intracranial spindle cell tumors.
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[26]
TÍTULO / TITLE: - Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Exp Ther Med. 2012 Nov;4(5):889-894. Epub 2012 Aug 28.
●● Enlace al texto completo (gratuito o de pago) 3892/etm.2012.685
AUTORES / AUTHORS: - Yin K; Liao Q; Zhong D; Ding J; Niu B; Long Q; Ding D
INSTITUCIÓN / INSTITUTION: - Departments of Orthopaedics.
RESUMEN / SUMMARY: - The goal of this study was to determine outcomes related to limb salvage vs. amputation for treating high-grade and localized osteosarcoma in patients with pathological fractures. Literature search was conducted using Medline, Embase and the Cochrane Database. Two reviewers independently assessed all eligible publications. The primary outcome measurement was pooled odds ratio (OR) and 95% confidence interval (CI) for the risk of local recurrence, 5-year overall survival rate and metastatic occurrence calculated through the fixed-effects method. Seven eligible studies were identified, which included a total of 284 patients. The risk for local recurrence and 5-year overall survival rate did not differ significantly (P>0.05) between the limb salvage group and amputation group, with an OR of 1.48 (95% CI, 0.67-3.30) and 1.85 (95% CI, 0.86-3.98), respectively. The risk for metastatic occurrence differed significantly (P<0.05), with an OR of 0.30 (95% CI, 0.10-0.91). The occurrence of a pathological fracture is not regarded as an absolute contraindication to limb salvage in patients with high-grade and localized osteosarcoma. Limb salvage as an alternative for treating high-grade and localized osteosarcoma in patients with pathological fracture does not greatly increase the risk for local recurrence or 5-year overall survival rate compared to amputation and has a lower risk for metastatic occurrence.
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[27]
TÍTULO / TITLE: - Dysphagia caused by spindle cell lipoma of hypopharynx: presentation of clinical case and literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Case Report Otolaryngol. 2012;2012:107383. doi: 10.1155/2012/107383. Epub 2012 Dec 26.
●● Enlace al texto completo (gratuito o de pago) 1155/2012/107383
AUTORES / AUTHORS: - Pena-Valenzuela A; Garcia Leon N
INSTITUCIÓN / INSTITUTION: - Otolaryngology Department, Universidad Nacional de Colombia, Carrera 35A No. 57-91, Apartamento 304, Bogota, Colombia.
RESUMEN / SUMMARY: - Spindle cell lipoma of the hypopharynx is an extremely rare entity. Here, we present the first case of this lesion originated in the cricopharyngeal region, with symptoms of chronic progressive dysphagia, which can be confused with other pathologies; endoscopic and magnetic resonance imaging (MRI) evaluation are the methods of choice for its diagnostic approach. The best therapeutic approach is endoscopic resection with rapid recovery and few complications. Long-term followup is recommended, either endoscopic or imaging, given that it can be confused with an undiagnosed liposarcoma; additionally, its long-term behavior is unknown.
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[28]
TÍTULO / TITLE: - New drugs and combinations for the treatment of soft-tissue sarcoma: a review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Cancer Manag Res. 2012;4:397-411. doi: 10.2147/CMAR.S23257. Epub 2012 Nov 23.
●● Enlace al texto completo (gratuito o de pago) 2147/CMAR.S23257
AUTORES / AUTHORS: - Somaiah N; von Mehren M
INSTITUCIÓN / INSTITUTION: - Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
RESUMEN / SUMMARY: - Sarcomas are a heterogeneous group of solid tumors arising from either soft tissues or bone, accounting for approximately 1% of all cancers in adults. Management of these diseases has changed little over the past 10 years, with the exception of treatment of gastrointestinal stromal tumors. Reasons for this stagnation include multiple histologies commonly grouped together in clinical trials limiting the understanding of benefit of treatment and limited investigation of molecular targeted therapies. More recently, advances in molecular pathogenesis, the advent of novel and targeted therapeutics, and increasing collaborations between sarcoma investigators has helped move the field forward in the right direction. Here, we review the recent data on novel agents tested for the management of adult soft-tissue sarcomas, excluding gastrointestinal stromal tumors.
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[29]
TÍTULO / TITLE: - Current status of multidisciplinary treatment for advanced gastrointestinal stromal tumors.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Nihon Shokakibyo Gakkai Zasshi. 2012;109(12):2031-41.
AUTORES / AUTHORS: - Kikuchi H; Ohta M; Konno H
INSTITUCIÓN / INSTITUTION: - Second Department of Surgery, Hamamatsu University School of Medicine.
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[30]
TÍTULO / TITLE: - Nerve sheath myxoma (neurothekeoma) of cerebellopontine angle: case report of a rare tumor with brief review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Turk Neurosurg. 2013;23(1):113-6. doi: 10.5137/1019-5149.JTN.4255-11.1.
●● Enlace al texto completo (gratuito o de pago) 5137/1019-5149.JTN.4255-11.1
AUTORES / AUTHORS: - Vij M; Jaiswal S; Agrawal V; Jaiswal A; Behari S
INSTITUCIÓN / INSTITUTION: - Christian Medical College, Department of Pathology, Vellore, India.
RESUMEN / SUMMARY: - Nerve sheath myxoma (neurothekeoma) are rare benign nerve sheath tumors, usually arising in the skin of the head and neck region and upper extremities in young females. To the best of author’s knowledge only two cases of intracranial neurothekeoma have been published in the English literature. These tumors were located in the parasellar area and in middle cranial fossa. This is the first case report of cerebellopontine angle neurothekeoma and third case report of intracranial neurothekeoma. This patient, a 45-year-old female, presented to us with complaints of right side progressive hearing loss for 12 months and swaying during walking for 8 months. Histologically the tumor had lobular appearance with spindle or stellate cells embedded in abundant myxoid background. The tumor cells were diffusely positive for S100. The patient was symptom free at eight month follow up.
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[31]
TÍTULO / TITLE: - Primary pulmonary angiosarcoma, an exceptional neoplasm with a poor prognosis: reports of two cases and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Gen Thorac Cardiovasc Surg. 2013 Jan 11.
●● Enlace al texto completo (gratuito o de pago) 1007/s11748-012-0200-6
AUTORES / AUTHORS: - Obeso Carillo GA; Garcia Fontan EM; Canizares Carretero MA; Perez Pedrosa A
INSTITUCIÓN / INSTITUTION: - Department of Thoracic Surgery, Vigo University Clinical Hospital, Pizarro No 22, 36204, Vigo, Pontevedra, España, andresobca@hotmail.com.
RESUMEN / SUMMARY: - Primary pulmonary angiosarcoma is a rare type of malignant vascular tumour characterised by proliferation of tumour cells with endothelial features. Up to date, only sixteen cases have been reported in English Literature. Treatment modalities vary from none to surgery, chemotherapeutic regimens, radiotherapy or immunotherapy, but none of them have been shown to be effective. Unfortunately, these tumours are usually very aggressive and overall mortality is very high. We present two cases of patients with a diagnosis of primary pulmonary angiosarcoma, the largest case series ever described, and a review of the scientific literature.
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[32]
TÍTULO / TITLE: - Myxofibrosarcoma arising in the maxillary sinus: a case report with a review of the ultrastructural findings and differential diagnoses.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - J Maxillofac Oral Surg. 2011 Dec;10(4):334-9. doi: 10.1007/s12663-011-0259-0. Epub 2011 Jul 27.
●● Enlace al texto completo (gratuito o de pago) 1007/s12663-011-0259-0
AUTORES / AUTHORS: - Norval EJ; Raubenheimer EJ
INSTITUCIÓN / INSTITUTION: - Department of Diagnostics, Oral and Dental Teaching Hospital, University of the Western Cape, Private Bag X1, Tygerberg, 7505 South Africa.
RESUMEN / SUMMARY: - This is a case report of a patient presenting with a destructive lesion with histologic features of a low grade malignancy in a predominantly myxoid matrix. Various low grade myxoid malignancies were considered in the differential diagnosis of which an overview is presented. A literature review of the ultrastructural findings and possible histogenesis is discussed along with the diagnostic criteria and recent change in the terminology regarding the malignancies previously diagnosed as myxoid malignant fibrous histiocytomas. A final diagnosis of a myxofibrosarcoma was only possible after assessing the immuno-histochemical profile, results of histochemical stains and ultrastructural features of this lesion.
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[33]
TÍTULO / TITLE: - Primary monophasic synovial sarcoma lung with brain metastasis diagnosed on transthoracic FNAC: Report of a case with literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Lung India. 2012 Oct;29(4):384-7. doi: 10.4103/0970-2113.102841.
●● Enlace al texto completo (gratuito o de pago) 4103/0970-2113.102841
AUTORES / AUTHORS: - Nuwal P; Dixit R; Shah NS; Samaria A
INSTITUCIÓN / INSTITUTION: - Department of Pathology, J. L. N. Medical College, Ajmer, Rajasthan, India.
RESUMEN / SUMMARY: - Synovial sarcoma is highly malignant tumor of soft tissues, occurring chiefly in the extremities and limb girdle with a propensity for local recurrence and sometimes metastases to the lungs. Primary synovial sarcoma arising in the lungs is rare and brain metastasis as presentation is further uncommon. We report a case of primary monophasic synovial sarcoma lung presenting with brain metastasis in a 35-year-old male patient. The diagnosis was made on percutaneous transthoracic needle aspiration from left-sided pulmonary mass and later confirmed by immunohistochemistry. The utility of preoperative diagnosis by percutaneous aspiration cytology is also stressed.
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[34]
TÍTULO / TITLE: - Laparoscopic management of right renal angiomyolipoma with involvement of the inferior vena cava: Case report and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Scand J Urol. 2012 Dec 4.
●● Enlace al texto completo (gratuito o de pago) 3109/00365599.2012.747563
AUTORES / AUTHORS: - Fernandez-Pello S; Gonzalez Rodriguez I; Villamil LR; Perez-Carral JR; Menendez CL; Caveda P; Cuervo J
INSTITUCIÓN / INSTITUTION: - Departments of Urology.
RESUMEN / SUMMARY: - Abstract This article reports the case of a 22-year-old woman with right renal angiomyolipoma (AML) and inferior vena cava thrombus. Laparoscopic right nephrectomy and thrombectomy were performed. To the authors’ knowledge there have been only 46 reported cases of renal AML with endovascular extension and this is the first case to be completely removed by a laparoscopic approach. Laparoscopic management of this kind of tumour is feasible in spite of the vascular involvement. The centre’s experience and enlargement of the tumour are key points for this approach.
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[35]
TÍTULO / TITLE: - Adenosquamous carcinoma of the uncinate process of the pancreas with synchronous gastrointestinal stromal tumor of the stomach: Case report and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Oncol Lett. 2012 Dec;4(6):1191-1194. Epub 2012 Sep 7.
●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.902
AUTORES / AUTHORS: - He JJ; Ding KF; Zheng L; Xu JH; Li J; Wu YL; Sun LF; Zhou DE; Zheng S
INSTITUCIÓN / INSTITUTION: - Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China ;
RESUMEN / SUMMARY: - Recently, the coexistence of gastrointestinal stromal tumors (GISTs) with other neoplasms has been studied with increasing frequency. Coexistence of pancreatic cancer with GISTs remains a rarity; however, here, we report a very rare case of adenosquamous carcinoma (ASC) of the uncinate process of the pancreas with synchronous GISTs of the stomach in a 62-year-old female. The patient presented with epigastric discomfort and vomiting. Radiographic imaging revealed two masses; one located at the body of the stomach and the other located at the uncinate process of the pancreas. Intraoperatively, a fine needle aspiration biopsy was conducted in the uncinate process of the pancreas, which revealed the malignancy of the masses. A pancreaticoduodenectomy and partial gastrectomy were then conducted, and subsequent pathological examinations identified an ASC of the pancreas and a GIST of the stomach. In our case, contrary to the majority of previous cases of synchronous GISTs and other malignancies, GIST was not an incidental finding. The initial suspicion on the GIST as the underlying cause of clinical symptoms led to the discovery of the ASC of the uncinate process of the pancreas.
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[36]
TÍTULO / TITLE: - Primary calvarial angiosarcoma: A case report and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Surg Neurol Int. 2012;3:134. doi: 10.4103/2152-7806.102952. Epub 2012 Oct 29.
●● Enlace al texto completo (gratuito o de pago) 4103/2152-7806.102952
AUTORES / AUTHORS: - Khan IS; Thakur JD; Ahmed O; Shorter CD; Thomas-Ogunniyl J; Kim MT; Jeroudi MA; Guthikonda B
INSTITUCIÓN / INSTITUTION: - Department of Neurosurgery, LSU HSC Shreveport, Shreveport, LA, USA.
RESUMEN / SUMMARY: - BACKGROUND: Angiosarcomas are high-grade endothelial tumors remarkable for their rarity and malignant behavior. Primary calvarial angiosarcoma is an extremely rare entity and its behavior usually sets it apart from other angiosarcoma types. We highlight the successful management of cranial angiosarcoma using a multidisciplinary approach. CASE DESCRIPTION: We present a 16-year-old male who was first noted to have a right-sided parietal cranial mass that was biopsied in 2008. Pathology was initially thought to be Kaposiform hemangioendothelioma. The patient subsequently underwent chemotherapy with vincristine. The patient did well until early 2010, when he suffered a right-sided intraparenchymal intratumoral hemorrhage. At this time, the original pathologic diagnosis was revisited and the diagnosis was upgraded to an angiosarcoma. The patient underwent a second round of chemotherapy using vincristine, cyclophosphamide, and actinomycin. The tumor continued to progress despite this treatment and he developed extensive skull deformity. At this point more definitive surgical intervention was reconsidered. Preoperative embolization of the mass was performed followed by aggressive surgical resection of the bony disease. The patient tolerated the procedure well and was discharged 6 days postoperatively without any new deficits. The patient is currently in the process of completing radiation therapy to entire tumor bed. He has clinically done well with no neurologic deterioration and has demonstrated long-term survival (>3 years). CONCLUSION: With the combined efforts of pediatric oncology, radiation oncology, interventional neuroradiology, and neurosurgery, a survival of greater than 3 years is possible with this aggressive pathology.
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[37]
TÍTULO / TITLE: - Giant solitary synovial osteochondromatosis of the elbow causing ulnar nerve neuropathy: a case report and review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - J Brachial Plex Peripher Nerve Inj. 2013 Jan 25;8(1):1.
●● Enlace al texto completo (gratuito o de pago) 1186/1749-7221-8-1
AUTORES / AUTHORS: - Al-Najjim M; Mustafa A; Fenton C; Morapudi S; Waseem M
RESUMEN / SUMMARY: - ABSTRACT: INTRODUCTION: Giant or solitary osteochondroma is part of a rare disorder known as synovial osteochondromatosis. It forms part of a spectrum of disease characterized by metaplastic changes within the joint synovium that are eventually extruded as loose bodies. It has been suggested that solitary synovial osteochondroma forms as progression of synovial osteochondromatosis through a process of either coalescence of multiple smaller bodies or the growth of a dominant synovial osteochondroma. Previous studies have shown that it occurs as a late phase of the disease. We report a rare case of giant synovial osteochondromatosis at the elbow causing ulnar nerve neuropathy and mechanical symptoms which has not been previously reported in the literature.Case Report: We report a case of a 56 year old Western European gentleman who presented with ulnar nerve neuropathy and swelling behind the elbow. The patient underwent MR imaging and subsequent biopsy that demonstrated synovial osteochondromatosis. Initially the patient declined surgery and opted for a watch and wait approach. Five years later he returned with worsening symptoms and underwent successful surgical resection of a giant solitary synovial osteochondroma. CONCLUSION: The unique outcome in our patient despite the long interval between presentation and surgical treatment resulted in early full resolution of symptoms within a short period. It may suggest an improved prognosis as compared to multiple synovial osteochondromatosis in terms of mechanical and neurological outcomes.
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[38]
TÍTULO / TITLE: - Liposarcoma of the spermatic cord mimicking a left inguinal hernia: a case report and literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - World J Surg Oncol. 2013 Jan 25;11(1):18.
●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-18
AUTORES / AUTHORS: - Li F; Tian R; Yin C; Dai X; Wang H; Xu N; Guo K
RESUMEN / SUMMARY: - ABSTRACT: Liposarcoma of the spermatic cord (LSC) is a rare condition characterized by a painless inguinal or scrotal mass. To our knowledge, only about 200 cases have been previously reported in the literature. These tumors are often mistaken for common scrotal swellings, such as hydroceles and hernias. We present a LSC case in which a definitive diagnosis was obtained upon histological examination. We also provide a literature review of other cases that have been reported.
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[39]
TÍTULO / TITLE: - A rare presentation of hepatic and splenic cystic malignant fibrous histiocytoma: A case report and literature review.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Int J Surg Case Rep. 2013;4(1):139-41. doi: 10.1016/j.ijscr.2012.11.004. Epub 2012 Nov 10.
●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2012.11.004
AUTORES / AUTHORS: - Das A; Arya SV; Soni N; Gowda GG; Kalwaniya DS
INSTITUCIÓN / INSTITUTION: - Department of General Surgery, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India. Electronic address: dr.anupam@rediffmail.com.
RESUMEN / SUMMARY: - INTRODUCTION: Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in late adult life. But primary visceral malignant fibrous histiocytoma is a very rare entity. In peripheries, it is known to have an aggressive behavior but its biological pattern when involving liver and spleen is not well understood due to the rarity of its occurrence. PRESENTATION OF CASE: A case of malignant fibrous histiocytoma of the liver and spleen as multiple cystic lesions in a 30 years old man is reported. The patient presented with hepatosplenomegaly resulting in central abdominal distention. Pre-operative investigations pointed toward the diagnosis of malignant cystic disease. The tumor presented as multiple hepatic cysts with massive hepatomegaly and splenomegaly. These cysts contained hemorrhagic fluid. Biopsy revealed highly cellular pleomorphic spindle cells fascicles arranged in storiform pattern at places with frequent mitoses. Immunohistochemistry revealed viamentin positivity. The tumor is compared with previous case reports. DISCUSSION: Malignant fibrous histiocytoma of liver and spleen has been mentioned in the literature as isolated case reports and most of these present as solid lesions but presentation as multiple cysts is also a possibility as was seen in this patient. It can be confirmed only on histo-pathology supported by immunohistochemistry. The disease carries guarded prognosis due to its rapid progression and diagnostic dilemma pre-operatively. CONCLUSION: This rare malignancy affecting the viscera can be diagnosed only with high index of suspicion and awareness regarding its presentation can help surgeons deal with it.
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[40]
TÍTULO / TITLE: - A rare tumor of the thyroid gland: report on one case of leiomyosarcoma and review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Updates Surg. 2013 Jan 20.
●● Enlace al texto completo (gratuito o de pago) 1007/s13304-013-0196-1
AUTORES / AUTHORS: - Mouaqit O; Belkacem Z; Ifrine L; Mohsine R; Belkouchi A
INSTITUCIÓN / INSTITUTION: - Surgery Department <<A>>, Ibn Sina University Hospital, Rabat, Morocco, mouaqit1975@hotmail.com.
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[41]
TÍTULO / TITLE: - Giant cell tumor of rib arising anteriorly as a large inframammary mass: a case report and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Case Report Med. 2012;2012:850509. doi: 10.1155/2012/850509. Epub 2012 Nov 27.
●● Enlace al texto completo (gratuito o de pago) 1155/2012/850509
AUTORES / AUTHORS: - Sharma A; Armstrong AE
INSTITUCIÓN / INSTITUTION: - Division of Transplantation Surgery, Department of Surgery, Virginia Commonwealth University, P.O. Box 980057, Richmond, VA 23298, USA.
RESUMEN / SUMMARY: - Introduction. Giant cell tumor of the bone is a rare benign lesion that infrequently affects the ribs, and if present, is usually located posteriorly. The rarity of this tumor poses diagnostic and therapeutic problems for physicians, especially when it is located in the anterior arc of the rib in close proximity to the breasts in female patients. Case Presentation. We report the case of a 32-year-old Asian female with a giant cell tumor of her anterior rib, presenting as a large inframammary mass. Computed tomography showed a tumor arising from the 7th rib anteriorly with marginal sclerosis, cortical destruction, and a soft tissue mass. She was treated with surgical resection, and the defect was reconstructed primarily. The surgical specimen measured 28.0 x 24.0 cm. The microscopic examination showed a large number of multinucleate giant cells scattered over the parenchyma. Patient recovered uneventfully and continues to be recurrence-free six years after surgical resection. Conclusion. We report the largest known case of giant cell tumor arising from the anterior aspect of a rib. We recommend including giant cell tumor in the differential diagnosis of chest wall masses especially in female patients, regardless of the size on clinical examination.
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[42]
TÍTULO / TITLE: - Primary ovarian adenosarcoma with elevated Ca-125 levels and normal ascitic fluid cytology: a case report and review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Ecancermedicalscience. 2012;6:284. doi: 10.3332/ecancer.2012.284. Epub 2012 Dec 17.
●● Enlace al texto completo (gratuito o de pago) 3332/ecancer.2012.284
AUTORES / AUTHORS: - Shakuntala P; Umadevi K; Usha A; Abhilasha N; Bafna U
INSTITUCIÓN / INSTITUTION: - Department of Gynaecologic Oncology, Kidwai Memorial Institute of Oncology, Dr. M.H. Mari Gowda Road, Bengaluru 560029, Karnataka, India.
RESUMEN / SUMMARY: - OBJECTIVE: Ovarian adenosarcoma is a very rare tumour for which treatment options vary. We will consider the option of optimal cytoreductive surgery followed by adjuvant chemotherapy consisting of ifosamide (mesna) and adriamycin to prevent systemic metastasis, and will observe the role of serial CA-125 levels as a follow-up marker. CASE REPORT: We report a case of ovarian adenosarcoma in a 38-year-old woman presenting with abdominal pain, distention due to massive ascites. She had undergone total abdominal hysterectomy 8 months previously for abnormal uterine bleeding. She underwent paracentesis followed by optimal cytoreductive surgery. A post-operative histopathologic diagnosis of primary adenosarcoma was confirmed. She was assigned a stage III C cancer. She received five cycles of ifosamise (mesna) and adriamycin and is on follow-up with serial CA-125 levels. There is no evidence of recurrence clinically, biochemically, or radiologically for more than 12 months. CONCLUSION: Multimodality treatment comprising optimal cytoreductive surgery followed by ifosamide (mesna) and adriamycin-based chemotherapy may be an option for treatment of these aggressive tumours. Follow-up with serial CA-125 values in advanced stage adenosarcoma of the ovary is a novel observation which needs to be researched.
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[43]
TÍTULO / TITLE: - Papillary thyroid carcinoma with fibromatosis-like stroma: A case report and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Oncol Lett. 2013 Jan;5(1):215-217. Epub 2012 Oct 24.
●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.993
AUTORES / AUTHORS: - Wu Z; Chu X; Fan S; Meng X; Xu C
INSTITUCIÓN / INSTITUTION: - Departments of General Surgery and.
RESUMEN / SUMMARY: - Papillary thyroid carcinoma with fibromatosis-like stroma (PTC-FLS) is a rare type of thyroid carcinoma that does not receive adequate follow-up. This study describes a case of PTC-FLS on the right side of the neck. The patient consented to a right hemithyroidectomy with a central compartment lymphadenectomy. Pathological examination revealed that the two initial lesions were consis tent with benign histological performance. Using immunohistology, the proliferated stromal cells were revealed to be positive for vimentin and smooth muscle actin (SMA), but negative for thyroglobulin, S-100 and CK. Post-operative follow-up was scheduled at 3-month intervals for 2 years and then at 6-month intervals for the next 3 years. There were no signs of tumor recurrence at the 5-year follow-up.
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[44]
TÍTULO / TITLE: - Colonic angiosarcoma: A case report and review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Int J Surg Case Rep. 2013;4(2):208-11. doi: 10.1016/j.ijscr.2012.11.021. Epub 2012 Dec 3.
●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2012.11.021
AUTORES / AUTHORS: - Al Beteddini OS; Brenez D; Firket C; Algaba R; Tabech A
INSTITUCIÓN / INSTITUTION: - Department of General and Digestive Surgery, IRIS Sud Hospitals, Brussels, Belgium.
RESUMEN / SUMMARY: - INTRODUCTION: Angiosarcomas are rare tumours that arise from the vascular endothelium. They can occur anywhere in the body, mostly affecting the head and neck. Their occurrence in the gastrointestinal tract is quite rare with a few reported cases in medical literature. PRESENTATION OF CASE: A 40-year-old man presented with metastatic sigmoid colon angiosarcoma, for which he was operated due to endoscopically uncontrollable massive tumour bleeding. The patient is presently still alive at 24 months after his first presentation. He is receiving palliative care. DISCUSSION: This article presents a review of the literature on this rare clinical entity, emphasising the very aggressive behaviour and the poor outcome of this malignancy. We present, briefly, 17 reported cases on primary colonic angiosarcoma since 1949. CONCLUSION: The role of chemotherapy and radiation is established neither in the adjuvant setting nor in metastatic disease. Surgery is the mainstay to treat localised colorectal angiosarcomas.
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[45]
TÍTULO / TITLE: - Pulmonary benign metastasizing leiomyoma: a case report and review of the literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - World J Surg Oncol. 2012 Dec 12;10:268. doi: 10.1186/1477-7819-10-268.
●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-10-268
AUTORES / AUTHORS: - Fu Y; Li H; Tian B; Hu B
INSTITUCIÓN / INSTITUTION: - Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China. huilee@vip.sina.com.
RESUMEN / SUMMARY: - ABSTRACT: Pulmonary benign metastasizing leiomyoma characterized by the growth of uterine leiomyoma in the lung is a very rare disease. We herein report the case of a 46-year-old asymptomatic woman who underwent a total abdominal hysterectomy for her multiple uterine leiomyomas 5 years ago, with the presence of multiple shadows in her chest roentgenogram during the regular check-up. Chest computerized tomography (CT) showed multiple solitary nodules in both lungs. Video-assisted thoracoscopic surgery with a wedge resection of the lesion was performed. Histopathologically, the pulmonary nodule was composed of benign smooth muscle cells and demonstrated low mitotic activity and absence of necrosis. Immunohistochemical staining for smooth muscle actin (SMA) and Desmin were extremely positive. CD10, CD117 and S-100 were negative in the tumor cells. Positive immunoreactivity for estrogen receptor (ER) and progesterone receptor (PR) were detected. The pathological diagnosis was pulmonary benign metastasizing leiomyoma.
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[46]
TÍTULO / TITLE: - Spontaneous perforation of jejunal gastrintestinal stromal tumour (gist). Case report and review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - World J Emerg Surg. 2012 Nov 29;7(1):37. doi: 10.1186/1749-7922-7-37.
●● Enlace al texto completo (gratuito o de pago) 1186/1749-7922-7-37
AUTORES / AUTHORS: - Roy SD; Khan D; De KK; De U
INSTITUCIÓN / INSTITUTION: - Department of surgery, Medical College Hospital, 88, College Street, Kolkata, 73, India. utpalde@vsnl.net.
RESUMEN / SUMMARY: - ABSTRACT: GIST is the commonest mesenchymal tumour of the gastrointestinal tract. Jejunal GIST is rare and spontaneous perforation of asymptomatic jejunal GIST is unique. A review of the English literature reveals only fifteen cases of perforated GIST till date. Pre-operative diagnosis is difficult. Diagnosis is confirmed on histopathology and immuno-histochemistry. Complete removal with postoperative imatinib therapy entails optimal treatment. Perforated GIST is associated with high recurrence.
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[47]
TÍTULO / TITLE: - Management of uterine leiomyomas in pregnancy: review of literature.
RESUMEN / SUMMARY: - Enlace al Resumen / Link to its Summary
REVISTA / JOURNAL: - Updates Surg. 2013 Jan 30.
●● Enlace al texto completo (gratuito o de pago) 1007/s13304-013-0198-z
AUTORES / AUTHORS: - Vitale SG; Tropea A; Rossetti D; Carnelli M; Cianci A
INSTITUCIÓN / INSTITUTION: - Gynecology and Obstetrics Unit, Department of Obstetrics and Gynecology and Radiological Sciences, University of Catania, Catania, Italy, vitalesalvatore@hotmail.com.
RESUMEN / SUMMARY: - The incidence of uterine myomas in pregnancy is estimated from 0.1 to 3.9 %. Although a lot of women with uterine fibroids bring the pregnancy without adverse events, data provided in the literature suggest that uterine fibromyomas are associated with several complications. The most important clinic question concerns the impact of myoma on pregnancy and, in some cases, the possibility of a surgical treatment that guarantees a good security for the pregnancy course and the conservation of reproductive capacity. Electronic search of Pubmed between 1993 and 2011, using specific keywords. Management of leiomyomas in pregnancy is conservative and limited, when it is necessary, to medical therapy. The main conditions that induce inevitably the surgical procedure are the torsion of pedunculated fibroid or rare cases of necrosis and resultant inflammatory peritoneal reaction. Laparoscopy technique has several advantages in comparison to previous techniques such as best postoperative course with reduction of pain, fast recovery, less hospitalization and, absence of large and unaesthetic scars. The importance of maternal and fetal welfare thus requires a careful evaluation of several factors that, varying from case to case, lead the authors to choose the most appropriate management.
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