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[1]

TÍTULO / TITLE:  - Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Lancet. 2013 Jan 10. pii: S0140-6736(12)61767-X. doi: 10.1016/S0140-6736(12)61767-X.

            ●● Enlace al texto completo (gratuito o de pago) 1016/S0140-6736(12)61767-X

AUTORES / AUTHORS:  - Bissler JJ; Kingswood JC; Radzikowska E; Zonnenberg BA; Frost M; Belousova E; Sauter M; Nonomura N; Brakemeier S; de Vries PJ; Whittemore VH; Chen D; Sahmoud T; Shah G; Lincy J; Lebwohl D; Budde K

INSTITUCIÓN / INSTITUTION:  - Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA. Electronic address: john.bissler@cchmc.org.

RESUMEN / SUMMARY:  - BACKGROUND: Angiomyolipomas are slow-growing tumours associated with constitutive activation of mammalian target of rapamycin (mTOR), and are common in patients with tuberous sclerosis complex and sporadic lymphangioleiomyomatosis. The insidious growth of these tumours predisposes patients to serious complications including retroperitoneal haemorrhage and impaired renal function. Everolimus, a  rapamycin derivative, inhibits the mTOR pathway by acting on the mTOR complex 1.  We compared the angiomyolipoma response rate on everolimus with placebo in patients with tuberous sclerosis or sporadic lymphanioleiomyomatosis-associated angiomyolipomata. METHODS: In this double-blind, placebo-controlled, phase 3 trial, patients aged 18 years or older with at least one angiomyolipoma 3 cm or larger in its longest diameter (defined by radiological assessment) and a definite diagnosis of tuberous sclerosis or sporadic lymphangioleiomyomatosis were randomly assigned, in a 2:1 fashion with the use of an interactive web response system, to receive oral everolimus 10 mg per day or placebo. The primary efficacy endpoint was the proportion of patients with confirmed angiomyolipoma response of at least a 50% reduction in total volume of target angiomyolipomas relative to baseline. This study is registered with ClinicalTrials.gov number NCT00790400. RESULTS: 118 patients (median age 31.0 years; IQR 18.0-61.0) from 24 centres in 11 countries were randomly assigned to receive everolimus (n=79) or placebo (n=39). At the data cutoff, double-blind treatment was ongoing for 98 patients; two main reasons for discontination were disease progression (nine placebo patients) followed by adverse events (two everolimus patients; four placebo patients). The angiomyolipoma response rate was 42% (33 of 79 [95% CI 31-53%]) for everolimus and 0% (0 of 39 [0-9%]) for placebo (response rate difference 42% [24-58%]; one-sided Cochran-Mantel-Haenszel test p<0.0001). The most common adverse events in the everolimus and placebo groups were stomatitis (48% [38 of 79], 8% [3 of 39], respectively), nasopharyngitis (24% [19 of 79] and 31% [12 of 39]), and acne-like skin lesions (22% [17 of 79] and 5% [2 of 39]). INTERPRETATION: Everolimus reduced angiomyolipoma volume with an acceptable safety profile, suggesting it could be a potential treatment for angiomyolipomas  associated with tuberous sclerosis. FUNDING: Novartis Pharmaceuticals.

 

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[2]

TÍTULO / TITLE:  - Images in clinical medicine. Lipoma of the tongue.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - N Engl J Med. 2012 Dec 20;367(25):e37. doi: 10.1056/NEJMicm1204020.

            ●● Enlace al texto completo (gratuito o de pago) 1056/NEJMicm1204020

AUTORES / AUTHORS:  - Boffano P; Gallesio C

INSTITUCIÓN / INSTITUTION:  - University of Turin, Turin, Italy. paolo.boffano@gmail.com

 

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[3]

TÍTULO / TITLE:  - Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by  integrative sequencing.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nat Genet. 2013 Feb;45(2):180-5. doi: 10.1038/ng.2509. Epub 2013 Jan 13.

            ●● Enlace al texto completo (gratuito o de pago) 1038/ng.2509

AUTORES / AUTHORS:  - Robinson DR; Wu YM; Kalyana-Sundaram S; Cao X; Lonigro RJ; Sung YS; Chen CL; Zhang L; Wang R; Su F; Iyer MK; Roychowdhury S; Siddiqui J; Pienta KJ; Kunju LP; Talpaz M; Mosquera JM; Singer S; Schuetze SM; Antonescu CR; Chinnaiyan AM

INSTITUCIÓN / INSTITUTION:  - 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA. [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA. [3].

RESUMEN / SUMMARY:  - A 44-year old woman with recurrent solitary fibrous tumor (SFT)/hemangiopericytoma was enrolled in a clinical sequencing program including  whole-exome and transcriptome sequencing. A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 was detected. Transcriptome sequencing of 27 additional SFTs identified the presence of a NAB2-STAT6 gene fusion in all tumors. Using RT-PCR and sequencing, we detected this fusion in all 51 SFTs, indicating high levels of recurrence. Expression of NAB2-STAT6 fusion proteins was confirmed in SFT, and the predicted fusion products harbor the early growth response (EGR)-binding domain of NAB2 fused to the activation domain of STAT6. Overexpression of the NAB2-STAT6 gene fusion induced proliferation in cultured cells and activated the expression of EGR-responsive genes. These studies establish NAB2-STAT6 as the defining driver mutation of SFT and provide an example of how neoplasia can be initiated by converting a transcriptional repressor of mitogenic pathways into a transcriptional activator.

 

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[4]

TÍTULO / TITLE:  - Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nat Genet. 2013 Feb;45(2):131-2. doi: 10.1038/ng.2522. Epub 2013 Jan 13.

            ●● Enlace al texto completo (gratuito o de pago) 1038/ng.2522

AUTORES / AUTHORS:  - Chmielecki J; Crago AM; Rosenberg M; O’Connor R; Walker SR; Ambrogio L; Auclair D; McKenna A; Heinrich MC; Frank DA; Meyerson M

INSTITUCIÓN / INSTITUTION:  - 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3].

RESUMEN / SUMMARY:  - Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.

 

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[5]

TÍTULO / TITLE:  - Phase I/IIa trial of the mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) administered orally in patients with refractory or advanced malignancies and sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Oncol. 2012 Dec 4.

            ●● Enlace al texto completo (gratuito o de pago) 1093/annonc/mds602

AUTORES / AUTHORS:  - Mita MM; Poplin E; Britten CD; Tap WD; Rubin EH; Scott BB; Berk L; Rivera VM; Loewy JW; Dodion P; Haluska F; Sarantopoulos J; Mita A; Tolcher A

INSTITUCIÓN / INSTITUTION:  - Cancer Therapy Research Center, Institute for Drug Development, San Antonio.

RESUMEN / SUMMARY:  - BackgroundRidaforolimus is an inhibitor of mTOR with evidence of antitumor activity in an I.V. formulation. This multicenter, open-label, 3 + 3 design nonrandomized, dose-escalation, phase I/IIa trial was conducted to determine the  safety, pharmacokinetic (PK) and pharmacodynamic parameters, maximum tolerated dose, and antitumor activity of oral ridaforolimus.Patients and methodsPatients with metastatic or unresectable solid tumors refractory to therapy were eligible. Seven different continuous and intermittent dosing regimens were examined.ResultsOne hundred and forty-seven patients were enrolled in this study  among which 85 were patients with sarcoma. Stomatitis was the most common DLT observed. The dosing regimen, 40 mg QD 5 days/week, provided the best combination of cumulative dose, dose density, and cumulative exposure, and was the recommended dosing regimen for subsequent clinical development. PK was nonlinear, with less than proportional increases in day-1 blood AUC(0-infinity) and C(max),  particularly with doses >40 mg. The terminal half-life estimate of ridaforolimus  (QD 5 40 mg) was 42.0 h, and the mean half-life approximately 30-60 h. The clinical benefit rate, (complete response, partial response, or stable disease for >/=4 months was 24.5% for all patients and 27.1% for patients with sarcoma.ConclusionOral ridaforolimus had an acceptable safety profile and exhibited antitumor activity in patients with sarcoma and other malignancies.ClinicalTrials.gov IdentifierNCT00112372.

 

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[6]

TÍTULO / TITLE:  - Prognostic factors and clinical outcome of patients with Ewing’s sarcoma family of tumors in adults: multicentric study of the Anatolian Society of Medical Oncology.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Mar;30(1):469. doi: 10.1007/s12032-013-0469-z. Epub 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-013-0469-z

AUTORES / AUTHORS:  - Arpaci E; Yetisyigit T; Seker M; Uncu D; Uyeturk U; Oksuzoglu B; Demirci U; Coskun U; Kucukoner M; Isikdogan A; Inanc M; Alkis N; Ozkan M

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Sakarya Training and Research Hospital, Sakarya,  Turkey, doktorerkan2001@yahoo.com.

RESUMEN / SUMMARY:  - The aim of this study was to evaluate prognostic factors, survival rate and the efficacy of the treatment modalities used in patients with Ewing sarcoma family of tumors (ESFT). Data of patients with ESFTs followed up at different cancer centers in Turkey between 2001 and 2010 were retrospectively analyzed. The median age of 114 patients was 26 years (range 14-66). The median follow-up was 20 months (range 1-118 months). Tumor size was between 1.5 and 14 cm (median 8 cm).  Eighty-six percent of patients had localized disease at presentation, and 14 % had metastatic disease. Local therapy was surgery alone in 31 % of patients, surgery combined with radiotherapy in 41 % and radiotherapy alone in 18 %. Approximately 70 % of patients were treated with vincristine, doxorubicin, cyclophosphamide and actinomycin-D, alternating with ifosfamide and etoposide every 3 weeks. In patients with localized disease at presentation, the 5-year disease-free survival and overall survival were 60 and 65 %, respectively. At univariate analysis, patients with tumor size >/=8 cm, high serum lactate dehydrogenase, metastasis at presentation, poor histological response to chemotherapy and positive surgical margin had significantly worse event-free survival. The significant predictors of worse overall survival at univariate analysis were tumor size </=8 cm, high lactate dehydrogenase, metastasis at presentation, poor histological response to chemotherapy, radiotherapy only as local treatment and positive surgical margin. ESFTs are aggressive tumors with a  high incidence of local recurrence and distant metastasis. Multimodality treatment consisting of adequate surgical resection, aggressive chemotherapy (VAC alternating with IE) and radiotherapy is recommended for patients with ESFTs.

 

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[7]

TÍTULO / TITLE:  - Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Proc Natl Acad Sci U S A. 2013 Jan 2.

            ●● Enlace al texto completo (gratuito o de pago) 1073/pnas.1215759110

AUTORES / AUTHORS:  - Varghese BV; Koohestani F; McWilliams M; Colvin A; Gunewardena S; Kinsey WH; Nowak RA; Nothnick WB; Chennathukuzhi VM

INSTITUCIÓN / INSTITUTION:  - Departments of Molecular and Integrative Physiology and Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160.

RESUMEN / SUMMARY:  - Uterine fibroids (leiomyomas) are the most common tumors of the female reproductive tract, occurring in up to 77% of reproductive-aged women, yet molecular pathogenesis remains poorly understood. A role for atypically activated mammalian target of rapamycin (mTOR) pathway in the pathogenesis of uterine fibroids has been suggested in several studies. We identified that G protein-coupled receptor 10 [GPR10, a putative signaling protein upstream of the  phosphoinositide 3-kinase-protein kinase B/AKT-mammalian target of rapamycin (PI3K/AKT-mTOR) pathway] is aberrantly expressed in uterine fibroids. The activation of GPR10 by its cognate ligand, prolactin releasing peptide, promotes  PI3K-AKT-mTOR pathways and cell proliferation specifically in cultured primary leiomyoma cells. Additionally, we report that RE1 suppressing transcription factor/neuron-restrictive silencing factor (REST/NRSF), a known tumor suppressor, transcriptionally represses GPR10 in the normal myometrium, and that the loss of  REST in fibroids permits GPR10 expression. Importantly, mice overexpressing human GPR10 in the myometrium develop myometrial hyperplasia with excessive extracellular matrix deposition, a hallmark of uterine fibroids. We demonstrate previously unrecognized roles for GPR10 and its upstream regulator REST in the pathogenesis of uterine fibroids. Importantly, we report a unique genetically modified mouse model for a gene that is misexpressed in uterine fibroids.

 

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[8]

TÍTULO / TITLE:  - Adjuvant therapy for high-grade, uterus-limited leiomyosarcoma: Results of a phase 2 trial (SARC 005).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer. 2013 Jan 18. doi: 10.1002/cncr.27942.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cncr.27942

AUTORES / AUTHORS:  - Hensley ML; Wathen JK; Maki RG; Araujo DM; Sutton G; Priebat DA; George S; Soslow RA; Baker LH

INSTITUCIÓN / INSTITUTION:  - Department of Medicine, Gynecologic Medical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York. hensleym@mskcc.org.

RESUMEN / SUMMARY:  - BACKGROUND: Between 30% and 50% of women who have high-grade uterine leiomyosarcoma (uLMS) limited to the uterus at diagnosis remain progression-free  at 2 years. Adjuvant pelvic radiation does not improve outcome. The objective of  the current study was to determine the 2-year and 3-year progression-free survival (PFS) among a prospective cohort of women who received adjuvant gemcitabine plus docetaxel followed by doxorubicin. METHODS: Women with uterus-limited, high-grade uLMS and adequate organ function were eligible. Within 12 weeks of complete resection and after confirmation that they had no evidence of disease on computed tomography (CT) images, the patients received 4 cycles of  fixed-dose-rate gemcitabine plus docetaxel. Those who were confirmed disease-free on CT scans after cycle 4 received 4 cycles of doxorubicin. CT imaging for recurrence was performed every 3 months for 2 years, then every 6 months for 3 years. RESULTS: In total, 47 women were enrolled (46 evaluable) in 3 years. Characteristics included a median age of 53 years; 1988 International Federation  of Gynecology and Obstetrics stage I disease in 81% of patients, stage II disease in 15%, and serosa-only stage IIIA disease in 4%; American Joint Committee on Cancer stage II disease in 13% of patients and stage III disease in 87%; a median tumor size of 8 cm (range, 2.5-30 cm); and a median mitotic rate of 18 mitoses per 10 high-power fields (range, 5-83 mitoses per 10 high-power fields). At a median follow-up of 39.8 months, 21 of 46 patients developed recurrent disease (45.7%). The median time to recurrence was 27.4 months (range, 3-40 months). Seventy-eight percent of patients (95% confidence interval, 67%-91%) were progression-free at 2 years, and 57% (95% confidence interval, 44%-74%) were progression-free at 3 years. The median PFS was not reached and exceeded 36 months. CONCLUSIONS: Among women with high-grade, uterus-limited uLMS who received treatment with adjuvant gemcitabine plus docetaxel followed by doxorubicin, 78% remained progression-free at 2 years, and 57% remained progression-free at 3 years. A randomized trial of adjuvant chemotherapy versus observation to determine whether adjuvant chemotherapy can improve survival in women with uterus-limited uLMS is underway. Cancer 2013. © 2013 American Cancer Society.

 

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[9]

TÍTULO / TITLE:  - Pleomorphic Rhabdomyosarcoma in a Patient With Hereditary Nonpolyposis Colorectal Cancer.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Jan 14.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.43.4910

AUTORES / AUTHORS:  - Cranmer LD; Chen CC; Morgan S; Martino G; Ray J

INSTITUCIÓN / INSTITUTION:  - University of Arizona Cancer Center, Tucson, AZ.

 

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[10]

TÍTULO / TITLE:  - Radiation therapy target volume reduction in pediatric rhabdomyosarcoma: Implications for patterns of disease recurrence and overall survival.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer. 2012 Dec 27. doi: 10.1002/cncr.27934.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cncr.27934

AUTORES / AUTHORS:  - Eaton BR; McDonald MW; Kim S; Marcus RB Jr; Sutter AL; Chen Z; Esiashvili N

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta Georgia. brupper@emory.edu.

RESUMEN / SUMMARY:  - BACKGROUND: The use of radiation therapy (RT) “cone-down” boost to reduce high-dose treatment volumes according to tumor response to induction chemotherapy in patients with pediatric rhabdomyosarcoma (RMS) may reduce treatment morbidity, yet the impact on tumor control is unknown. METHODS: Fifty-five children, including 18 (33%) with parameningeal (PM) RMS and 37 (67%) with non-PM RMS, who  received definitive treatment with chemotherapy and RT from April 2000 through January 2010 were retrospectively reviewed. RESULTS: In total, 28 patients (51%)  received a cone-down boost. The high-dose boost volume was reduced by a median of 56% of the initial target volume (range, 5%-91%). The median time to initiating RT was 3 weeks for patients with PM RMS and 16 weeks for patients with non-PM RMS (P < .001). After a median follow-up of 41 months, local failure occurred in 5 patients (9%), including 2 patients who received a cone-down boost, and there were no marginal failures. Twelve patients (67%) with PM RMS had intracranial tumor extension. In this subgroup, 4 patients (30%) who received a cone-down boost and had >/= 3 weeks between chemotherapy and RT initiation experienced leptomeningeal failure as their first site of disease progression, and a delayed  time to RT initiation was associated with decreased survival (P = .055) CONCLUSIONS: A cone-down boost allowed for significant reductions in high-dose RT treatment volume while maintaining excellent tumor control in most patients. However, in the subset of patients with PM RMS and intracranial tumor extension,  early RT initiation and wider margin RT to cover adjacent areas at high risk for  meningeal extension may be more important for adequate disease control. Cancer 2012. © 2012 American Cancer Society.

 

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[11]

TÍTULO / TITLE:  - Risk stratification models and mutational analysis: Keys to optimising adjuvant therapy in patients with gastrointestinal stromal tumour.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cancer. 2012 Nov 30. pii: S0959-8049(12)00859-3. doi: 10.1016/j.ejca.2012.10.025.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejca.2012.10.025

AUTORES / AUTHORS:  - Gronchi A

INSTITUCIÓN / INSTITUTION:  - Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: alessandro.gronchi@istitutotumori.mi.it.

RESUMEN / SUMMARY:  - Imatinib is a standard of care in the adjuvant treatment of patients with resected gastrointestinal stromal tumour (GIST). Two important trials have shown  a reduction in GIST recurrence rates for patients treated with imatinib 400mg daily for 1year; one of these trials also demonstrated a significant improvement  in overall survival for patients with GIST at high risk of recurrence who were treated for 3years. However, not all patients will benefit from adjuvant treatment. Considering the patient types in both trials, treatment decisions must take into account a number of factors including risk of recurrence and mutational status. Tumour characteristics including tumour size, location and mitotic index  are the main prognostic factors of recurrence-free survival (RFS) after surgical  resection of GISTs. Research, much of it in the advanced/metastatic setting, shows that mutational analysis is definitely predictive of treatment efficacy and probably prognostic of RFS. Patients on imatinib whose tumours harbour mutations  in exon 11 of the KIT gene tend to have superior RFS compared with patients with  exon 9 mutations. In contrast, patients with wild-type GIST often have disease that follows an indolent course and has limited sensitivity to imatinib in most cases. As such, increased use of existing risk-stratification schemes and mutational analysis will be essential for optimising tailored treatment approaches. In this review, the development and prognostic/predictive utility of  key risk stratification tools and mutational analysis of GIST are discussed herein with the goal of facilitating adjuvant treatment decisions for patients with GIST.

 

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[12]

TÍTULO / TITLE:  - Comparison of Genome-Wide Binding of MyoD in Normal Human Myogenic Cells and Rhabdomyosarcomas Identifies Regional and Local Suppression of Promyogenic Transcription Factors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Cell Biol. 2013 Feb;33(4):773-84. doi: 10.1128/MCB.00916-12. Epub 2012 Dec 10.

            ●● Enlace al texto completo (gratuito o de pago) 1128/MCB.00916-12

AUTORES / AUTHORS:  - Macquarrie KL; Yao Z; Fong AP; Diede SJ; Rudzinski ER; Hawkins DS; Tapscott SJ

INSTITUCIÓN / INSTITUTION:  - Divisions of Human Biology.

RESUMEN / SUMMARY:  - Rhabdomyosarcoma is a pediatric tumor of skeletal muscle that expresses the myogenic basic helix-loop-helix protein MyoD but fails to undergo terminal differentiation. Prior work has determined that DNA binding by MyoD occurs in the tumor cells, but myogenic targets fail to activate. Using MyoD chromatin immunoprecipitation coupled to high-throughput sequencing and gene expression analysis in both primary human muscle cells and RD rhabdomyosarcoma cells, we demonstrate that MyoD binds in a similar genome-wide pattern in both tumor and normal cells but binds poorly at a subset of myogenic genes that fail to activate in the tumor cells. Binding differences are found both across genomic regions and locally at specific sites that are associated with binding motifs for RUNX1, MEF2C, JDP2, and NFIC. These factors are expressed at lower levels in RD cells than muscle cells and rescue myogenesis when expressed in RD cells. MEF2C is located in a genomic region that exhibits poor MyoD binding in RD cells, whereas  JDP2 exhibits local DNA hypermethylation in its promoter in both RD cells and primary tumor samples. These results demonstrate that regional and local silencing of differentiation factors contributes to the differentiation defect in rhabdomyosarcomas.

 

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[13]

TÍTULO / TITLE:  - Estrogen receptor alpha mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down regulation of the Wnt antagonist Sost is mediated by Estrogen Receptor beta

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Biol Chem. 2013 Jan 29.

            ●● Enlace al texto completo (gratuito o de pago) 1074/jbc.M112.405456

AUTORES / AUTHORS:  - Galea GL; Meakin LB; Sugiyama T; Zebda N; Sunters A; Taipaleenmaki H; Stein GS; van Wijnen AJ; Lanyon LE; Price JS

INSTITUCIÓN / INSTITUTION:  - University of Bristol, United Kingdom;

RESUMEN / SUMMARY:  - Mechanical strain and estrogens both stimulate osteoblast proliferation through Estrogen Receptor (ER)-mediated effects and both down-regulate the Wnt antagonist Sost/sclerostin. Here we investigate the differential effects of ERalpha and beta in these processes in mouse long bone derived osteoblastic cells and human Saos-2 cells. Recruitment to the cell cycle following strain or 17beta-estradiol occurs  within 30 minutes, as determined by Ki-67 staining, and is prevented by the ERalpha antagonist MPP. ERbeta inhibition with PTHPP increases basal proliferation similarly to strain or estradiol. Both strain and estradiol down-regulate Sost expression, as does in vitro inhibition or in vivo deletion of ERalpha. The ERbeta agonists DPN and ERB041 also down-regulated Sost expression in vitro whereas the ERalpha agonist PPT or the ERbeta antagonist PTHPP has no effect. Tamoxifen, a non-genomic ERbeta agonist, down-regulates Sost expression in vitro and in bones in vivo. Inhibition of both ERs with fulvestrant or selective antagonism of ERbeta, but not ERalpha, prevents Sost down-regulation by strain or estradiol. Sost down-regulation by strain or ERbeta activation is prevented by Mek/ERK blockade. Exogenous sclerostin had no effect on estradiol-induced proliferation but prevents that following strain. Thus, in osteoblastic cells the acute proliferative effects of both estradiol and strain are ERalpha-mediated. Basal Sost down-regulation follows decreased activity of ERalpha and increased activity of ERbeta. Sost down-regulation by strain or increased estrogens is mediated by ERbeta, not ERalpha. ER-targeting therapy may  facilitate structurally appropriate bone formation by enhancing the distinct, ligand-independent, strain-related contributions to proliferation of both ERalpha and ERbeta.

 

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[14]

TÍTULO / TITLE:  - Uterine leiomyosarcoma and Leser-Trelat sign.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Lancet. 2013 Jan 5;381(9860):88. doi: 10.1016/S0140-6736(12)61805-4.

            ●● Enlace al texto completo (gratuito o de pago) 1016/S0140-6736(12)61805-4

AUTORES / AUTHORS:  - Abakka S; Elhalouat H; Khoummane N; Achaaban M; ElAmrani S; Bargach S; Yousfi M

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology, Oncology and high risk pregnancies, Maternity Hospital Souissi, University teaching hospital Ibn Sina of Rabat, Rabat, Morocco. sanaeabakka@gmail.com

 

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[15]

TÍTULO / TITLE:  - Metastatic alveolar rhabdomyosarcoma to the bone marrow mimicking acute leukemia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Blood. 2012 Nov 1;120(18):3632.

AUTORES / AUTHORS:  - Stall JN; Bailey NG

INSTITUCIÓN / INSTITUTION:  - University of Michigan Health Systems.

 

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[16]

TÍTULO / TITLE:  - The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells  imposes the phenotype of in vivo sarcoma development.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncogene. 2012 Dec 10. doi: 10.1038/onc.2012.507.

            ●● Enlace al texto completo (gratuito o de pago) 1038/onc.2012.507

AUTORES / AUTHORS:  - Rubio R; Gutierrez-Aranda I; Saez-Castillo AI; Labarga A; Rosu-Myles M; Gonzalez-Garcia S; Toribio ML; Menendez P; Rodriguez R

INSTITUCIÓN / INSTITUTION:  - GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, España.

RESUMEN / SUMMARY:  - Increasing evidence suggests that mesenchymal stem/stromal cells (MSCs) carrying  specific mutations are at the origin of some sarcomas. We have reported that the  deficiency of p53 alone or in combination with Rb (Rb(-/-) p53(-/-)) in adipose-derived MSCs (ASCs) promotes leiomyosarcoma-like tumors in vivo. Here, we hypothesized that the source of MSCs and/or the cell differentiation stage could  determine the phenotype of sarcoma development. To investigate whether there is a link between the source of MSCs and sarcoma phenotype, we generated p53(-/-) and  Rb(-/-)p53(-/-) MSCs from bone marrow (BM-MSCs). Both genotypes of BM-MSCs initiated leiomyosarcoma formation similar to p53(-/-) and Rb(-/-)p53(-/-) ASCs.  In addition, gene expression profiling revealed transcriptome similarities between p53- or Rb-p53-deficient BM-MSCs/ASCs and muscle-associated sarcomagenesis. These data suggest that the tissue source of MSC does not seem to determine the development of a particular sarcoma phenotype. To analyze whether the differentiation stage defines the sarcoma phenotype, BM-MSCs and ASCs were induced to differentiate toward the osteogenic lineage, and both p53 and Rb were  excised using Cre-expressing adenovectors at different stages along osteogenic differentiation. Regardless the level of osteogenic commitment, the inactivation  of Rb and p53 in BM-MSC-derived, but not in ASC-derived, osteogenic progenitors gave rise to osteosarcoma-like tumors, which could be serially transplanted. This indicates that the osteogenic differentiation stage of BM-MSCs imposes the phenotype of in vivo sarcoma development, and that BM-MSC-derived osteogenic progenitors rather than undifferentiated BM-MSCs, undifferentiated ASCs or ASC-derived osteogenic progenitors, represent the cell of origin for osteosarcoma development.Oncogene advance online publication, 10 December 2012; doi:10.1038/onc.2012.507.

 

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[17]

TÍTULO / TITLE:  - Risk of Kaposi sarcoma during the first months on combination antiretroviral therapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - AIDS. 2013 Feb 20;27(4):635-643.

            ●● Enlace al texto completo (gratuito o de pago) 1097/QAD.0b013e32835cba6c

AUTORES / AUTHORS:  - Lacombe JM; Boue F; Grabar S; Viget N; Gazaignes S; Lascaux-Cametz AS; Pacanowski J; Partisani M; Launay O; Matheron S; Rosenthal E; Rouveix E; Tattevin P; de Truchis P; Costagliola D; Goedert JJ

INSTITUCIÓN / INSTITUTION:  - aInserm UMR-S 943, UPMC Univ Paris 06 UMR-S 943, INSERM-TRANSFERT, Paris bAP-HP,  Hopital Antoine Beclere, Service de medecine interne et d’immunologie clinique, Universite Paris-Sud, Clamart cINSERM UMR-S 943, AP-HP, Groupe Hospitalier Cochin Hotel-Dieu, Unite de biostatistique et epidemiologie, Universite Paris Descartes, Paris dCentre Hospitalier de Tourcoing, Service universitaire des maladies infectieuses et du voyage, Tourcoing eAP-HP, Hopital Saint Louis, Service des maladies infectieuses et tropicales, Paris fAP-HP, Hopital Henri-Mondor, Service  d’immunologie clinique, Creteil gAP-HP, Hopital Saint Antoine, Service des maladies infectieuses et tropicales, Paris hHopitaux Universitaires de Strasbourg, Le Trait d’Union-Centre de soins de l’infection par le VIH, Strasbourg iUniversite Paris Descartes, AP-HP, Hopital Cochin jUniversite Denis Diderot Paris 7, AP-HP Hopital Bichat-Claude Bernard, Service de Maladies infectieuses et Tropicales, Paris kHopital l’Archet, Departement de medecine interne, Universite de Nice-Sophia Antipolis, Nice lHopital Ambroise Pare, Service de medecine interne, Boulogne mCHU Pontchaillou, Service des Maladies Infectieuses et de Reanimation Medicale, Rennes nAP-HP, Hopital Raymond Poincare, Service de medecine aigue specialisee, Garches oINSERM UMR-S 943, UPMC Univ Paris 06 UMR-S 943, Paris, France pDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.

RESUMEN / SUMMARY:  - OBJECTIVE:: To determine whether incident AIDS-defining Kaposi sarcoma or Pneumocystis jiroveci pneumonia (PJP) is associated with combination antiretroviral therapy (cART) initiation. DESIGN:: Compare risk for Kaposi sarcoma and PJP by time on cART and CD4 reconstitution. METHODS:: In the FHDH-ANRS CO4 cohort (N = 66 369), Kaposi sarcoma (N = 1811) and PJP (N = 1718) incidence rates were computed by demographic and HIV strata. Crude and adjusted relative risk (RR) with 95% confidence intervals (CIs) following cART initiation  were calculated by Poisson regression with untreated patients during 1996-2009 as reference. CD4 cell counts were compared by Wilcoxon rank sum tests. RESULTS:: The risk of Kaposi sarcoma was very high during months 1-3 on cART (N = 160, RRCrude 3.94, 95% CI 3.26-4.76), which was incompletely attenuated by adjustment  for demographics and contemporaneous CD4 cell count (RRAdj 1.25, 95% CI 1.02-1.53). Corresponding PJP risk was minimally elevated (N = 84, RRCrude 1.80,  95% CI 1.42-2.30) and markedly reduced with adjustment on the same variables and  PJP prophylaxis (RRAdj 0.52, CI 0.41-0.67). HIV load had no added effect. Median  CD4 cell count at cART initiation was much lower in patients with incident Kaposi sarcoma (82 cells/mul) or PJP (61 cells/mul) within 3 months than in those who did not develop these conditions (>250 cells/mul). Notably, median CD4 cell count change was +44 cells/mul per month with incident Kaposi sarcoma within 3 months of cART initiation versus 0 cells/mul per month with incident PJP (P = 0.0003). CONCLUSION:: Failure of CD4 cell count reconstitution during months 1-3 on cART fully accounted for incident PJP. In contrast, there were 1.6 additional Kaposi sarcoma cases per 1000 person-years during months 1-3 on cART, suggesting that immune reconstitution may contribute to the risk for AIDS-defining Kaposi sarcoma.

 

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[18]

TÍTULO / TITLE:  - Chromosome Instability Accounts for Reverse Metastatic Outcomes of Pediatric and  Adult Synovial Sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Jan 14.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.46.0147

AUTORES / AUTHORS:  - Lagarde P; Przybyl J; Brulard C; Perot G; Pierron G; Delattre O; Sciot R; Wozniak A; Schoffski P; Terrier P; Neuville A; Coindre JM; Italiano A; Orbach D; Debiec-Rychter M; Chibon F

INSTITUCIÓN / INSTITUTION:  - Pauline Lagarde, Celine Brulard, Gaelle Perot, Agnes Neuville, Jean-Michel Coindre, and Frederic Chibon, Institut National de la Sante et de la Recherche Medicale (INSERM) U916-Institut Bergonie; Pauline Lagarde, Gaelle Perot, Agnes Neuville, Jean-Michel Coindre, Antoine Italiano, and Frederic Chibon, Institut Bergonie; Jean-Michel Coindre, Universite Victor Segalen Bordeaux 2, Bordeaux; Gaelle Pierron, Olivier Delattre, Daniel Orbach, Institut Curie; Olivier Delattre, INSERM 830, Institut Curie, Paris; Philippe Terrier, Institut de cancerologie Gustave-Roussy, Villejuif, France; Joanna Przybyl, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology and Warsaw Medical University, Warsaw, Poland; Joanna Przybyl, Raf Sciot, Agnieszka Wozniak, Patrick Schoffski, Maria Debiec-Rychter, Katholieke Universiteit Leuven and University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

RESUMEN / SUMMARY:  - PURPOSESynovial sarcoma (SS) occurs in both children and adults, although metastatic events are much more common in adults. Whereas the importance of the t(X;18) translocation in SS oncogenesis is well established, the genetic basis of SS metastasis is still poorly understood. We recently reported expression (CINSARC; Complexity Index in Sarcoma) and Genomic Index prognostic signatures related to chromosome integrity in sarcomas and GI stromal tumors. Here we investigate whether these signatures can also predict outcomes in SS.Patients And methodsOne hundred patients who had primary untreated SS tumors were selected for expression and genomic profiling in a training/validation approach.ResultsCINSARC and Genomic Index have strong independent and validated prognostic values (P < .001). By comparing expression profiles of tumors with or without metastasis, 14  genes that are common to the CINSARC signature were identified, and the two top-ranked genes, KIF14 and CDCA2, were validated as prognostic markers in an independent cohort. Comparing genomic profiles of adult versus pediatric SS, we show that metastasis is associated with genome complexity in both situations and  that the adult genome is more frequently rearranged. Accordingly, pediatric patients with an even genomic profile do not develop metastasis. CONCLUSIONMetastasis development in SS is strongly associated with chromosome complexity, and CINSARC and Genomic Index are validated independent prognostic factors. The differences in metastasis frequency between adults and children are  associated with genome instability, which is much more frequent in adults. Genomic Index is potentially the best overall biomarker and clearly the most clinically relevant, considering that genome profiling from formalin-fixed samples is already used in pathology.

 

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[19]

TÍTULO / TITLE:  - Long-Term Outcomes in Patients with Radiation-Associated Angiosarcomas of the Breast Following Surgery and Radiotherapy for Breast Cancer.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Surg Oncol. 2012 Dec 6.

            ●● Enlace al texto completo (gratuito o de pago) 1245/s10434-012-2755-y

AUTORES / AUTHORS:  - Torres KE; Ravi V; Kin K; Yi M; Guadagnolo BA; May CD; Arun BK; Hunt KK; Lam R; Lahat G; Hoffman A; Cormier JN; Feig BW; Lazar AJ; Lev D; Pollock RE

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX, USA,  ketorres@mdanderson.org.

RESUMEN / SUMMARY:  - BACKGROUND: Radiation-associated angiosarcoma (RAAS) is a devastating disease occasionally observed in breast cancer patients treated with radiation. Due to its rarity, our knowledge-of disease risk factors, epidemiology, treatment, and outcome-is extremely limited. Therefore, we sought to identify clinicopathologic  factors associated with local and distant recurrence and disease-specific survival (DSS). METHODS: Radiation-associated angiosarcoma was defined as pathologically confirmed breast or chest wall angiosarcoma arising within a previously irradiated field. A comprehensive search of our institutional tumor registry (1/1/93 through 2/28/11) was used to identify patients (n = 95 females). Patient, original tumor, RAAS treatment, and outcome variables were retrospectively retrieved and assembled into a database. RESULTS: The median follow-up for all RAAS patients was 10.3 (range, 2.4-31.8) years. The latency period following radiation exposure ranged from 1.4 to 26 (median, 7) years. One-year and 5-year DSS rates were 93.5 and 62.6 %, respectively. Reduced risk of local recurrence was observed in patients who received chemotherapy (P = 0.0003). In multivariable analysis, size was found to be an independent predictor of adverse outcome (P = 0.015). CONCLUSIONS: Our study demonstrates that RAAS exhibits high recurrence rates. It also highlights the need for well-designed, multicenter, clinical trials to inform the true utility of chemotherapy in this disease.

 

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[20]

TÍTULO / TITLE:  - Temozolomide use in adult patients with gliosarcoma: an evolving clinical practice.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurooncol. 2012 Dec 25.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11060-012-1029-7

AUTORES / AUTHORS:  - Walker GV; Gilbert MR; Prabhu SS; Brown PD; McAleer MF

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 97, Houston, TX, 77030, USA.

RESUMEN / SUMMARY:  - The purpose of this study is to determine the factors that impact overall survival (OS) in adult patients with gliosarcoma in the modern era treated at a single institution compared with a cohort from the SEER registry. A total of 46 adult patients with pathologically confirmed gliosarcoma at MD Anderson Cancer Center from 2000 to 2010 were retrospectively analyzed. Demographic and treatment were obtained. For comparison, a total of 218 patients with gliosarcoma in the SEER database from 1991 to 2008 were analyzed. Survival analysis was conducted using the Kaplan-Meier log rank test. At MD Anderson, the overall incidence of gliosarcoma over the specified time interval was 1.5 %. Gliosarcoma was more common in males (n = 31, 67.4 %) with a median age of 56 years (range 24-92 years). Median survival in all patients was 12.5 months. A total of 17 patients (37 %) received temozolomide (TMZ) concurrently with RT and adjuvantly, with a 24 month OS of 20.0 %, compared with 10.2 % among those not treated with this regimen (p = 0.68). In contrast, the 2 year OS rate in the SEER database was 24.2 % during 2006-2008, compared to 12.1 % among those diagnosed in 2000-2003 (p = 0.03), presumably related to the widespread adoption of the chemoradiation regimen. Patients with gliosarcoma treated with TMZ at a single institution improved OS although this finding did not reach statistical significance. Patients diagnosed in the TMZ era in the SEER database display an improved OS, although the explanation for this finding requires further elucidation.

 

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[21]

TÍTULO / TITLE:  - Identification of a Novel Missense Mutation of PEX7 Gene in an Iranian Patient with Rhizomelic Chondrodysplasia Punctata Type 1.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gene. 2013 Jan 25. pii: S0378-1119(13)00063-2. doi: 10.1016/j.gene.2013.01.022.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.gene.2013.01.022

AUTORES / AUTHORS:  - Mohamadynejad P; Ghaedi K; Shafeghati Y; Salamian A; Tanhaie S; Karamali F; Rabiee F; Parivar K; Baharvand H; Nasr-Esfahani MH

INSTITUCIÓN / INSTITUTION:  - Biology Department, Science and Research Branch, Islamic Azad University (IAU), Tehran, Iran.

RESUMEN / SUMMARY:  - Deficiency in the PTS2 protein import pathway due to mutations in PEX7 gene results in the rhizomelic chondrodysplasia punctata (RCDP) type 1. In the present study, we have reported a novel missense mutation, W75R, in the PEX7 gene in an Iranian patient with the RCDP type 1. The inability of PEX7 protein to transport  PTS2 containing proteins including peroxisomal 3-ketoacyl-CoA thiolase and PTS2-EGFP protein to the surface of the peroxisomes showed that the W75R mutation in PEX7 gene severely impaired the function of PEX7 protein and was responsible for RCDP type 1 in this patient.

 

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[22]

TÍTULO / TITLE:  - Everolimus for renal angiomyolipoma in tuberous sclerosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Lancet. 2013 Jan 10. pii: S0140-6736(12)61954-0. doi: 10.1016/S0140-6736(12)61954-0.

            ●● Enlace al texto completo (gratuito o de pago) 1016/S0140-6736(12)61954-0

AUTORES / AUTHORS:  - Sooriakumaran P; Anderson CJ

INSTITUCIÓN / INSTITUTION:  - Department of Urology, St George’s NHS Trust, London SW17 0QT, UK. Electronic address: sooriakumaran@gmail.com.

 

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[23]

TÍTULO / TITLE:  - No REST for fibroids.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Proc Natl Acad Sci U S A. 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1073/pnas.1222730110

AUTORES / AUTHORS:  - Rueda BR; Davis JS

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114.

 

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[24]

TÍTULO / TITLE:  - Dedifferentiated Liposarcoma With Unusual Kaposiform Morphology and Whorl Formation Masquerading As Kaposi’s Sarcoma: Diagnostically Challenging Case Confirmed by Cytogenetic and TP53 Mutation Analysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Jan 14.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.42.8763

AUTORES / AUTHORS:  - Subramaniam MM; Chan JY; Leow PC; Venkateswaran K; Nathan SS; Soong R; Lee VK

INSTITUCIÓN / INSTITUTION:  - National University Health System; Cancer Science Institute of Singapore, National University of Singapore, Singapore.

 

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[25]

TÍTULO / TITLE:  - Pheochromocytoma and gastrointestinal stromal tumors in patients with neurofibromatosis type I.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Med. 2013 Feb;126(2):174-80. doi: 10.1016/j.amjmed.2012.07.022.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.amjmed.2012.07.022

AUTORES / AUTHORS:  - Vlenterie M; Flucke U; Hofbauer LC; Timmers HJ; Gastmeier J; Aust DE; van der Graaf WT; Wesseling P; Eisenhofer G; Lenders JW

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

RESUMEN / SUMMARY:  - BACKGROUND: Neurofibromatosis I may rarely predispose to pheochromocytoma and gastrointestinal stromal tumors. METHODS: A 59-year-old woman with neurofibromatosis I presented with pheochromocytoma of the left adrenal gland. During surgery, 3 gastrointestinal stromal tumors adjacent to the stomach and small intestine were removed. Despite appropriate thrombosis prophylaxis, the patient died of a pulmonary embolus 2 days postoperatively. The second patient, a 55-year-old man with neurofibromatosis I and bilateral pheochromocytomas, had several small gastrointestinal stromal tumors adjacent to the jejunum during surgery. A review of the literature was conducted to identify patients with neurofibromatosis I with concurrence of pheochromocytoma and gastrointestinal stromal tumors and to define the specific clinical features of these patients. RESULTS: In addition to our 2 patients, 12 other cases of neurofibromatosis I with concomitant occurrence of pheochromocytomas and gastrointestinal stromal tumors have been reported. Pheochromocytomas had adrenal locations in all patients. Two of the 14 patients had a mixed pheochromocytoma/ganglioneuroma. In  4 of the 14 patients, gastrointestinal stromal tumors were located along the stomach. The gastrointestinal stromal tumors in our 2 patients showed no somatic  mutations in KIT and PDGFRA genes. A pulmonary embolism was diagnosed in 4 patients. CONCLUSIONS: The simultaneous occurrence of pheochromocytoma and gastrointestinal stromal tumor should be considered in all patients with neurofibromatosis I presenting with an abdominal mass with symptoms suggestive of pheochromocytoma. Therefore, a pheochromocytoma should be excluded before a patient with neurofibromatosis I undergoes surgery for a gastrointestinal stromal tumor because an undiagnosed pheochromocytoma carries a high risk of life-threatening cardiovascular complications during surgery. Finally, this combination may be associated with an increased risk for thromboembolic events, but more studies are necessary to confirm this.

 

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[26]

TÍTULO / TITLE:  - A case of nonleukemic myeloid sarcoma with FIP1L1-PDGFRA rearrangement: an unusual presentation of a rare disease.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2013 Jan;37(1):147-51. doi: 10.1097/PAS.0b013e31826df00b.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e31826df00b

AUTORES / AUTHORS:  - Chen D; Bachanova V; Ketterling RP; Begna KH; Hanson CA; Viswanatha DS

INSTITUCIÓN / INSTITUTION:  - Division of Hematopathology, Mayo Clinic, Rochester, MN 55905, USA. chen.dong@mayo.edu

RESUMEN / SUMMARY:  - Rearrangement of the PDGFRA gene defines a distinct group of hematopoietic neoplasms that commonly present with persistent eosinophilia and are highly sensitive to low-dose imatinib mesylate treatment. Although rare cases of PDGFRA  rearrangement-associated acute myeloid or lymphoblastic leukemia can occur, nonleukemic myeloid sarcoma has not been reported, and its sensitivity to imatinib treatment is unknown. Herein, we report a 31-year-old man with nonleukemic myeloid sarcoma and marked peripheral blood and bone marrow eosinophilia. Fluorescent in situ hybridization studies demonstrated that both bone marrow hematopoietic precursors and blasts of the myeloid sarcoma were positive for FIP1L1-PDGFRA rearrangement. The patient consequently received imatinib treatment at a dosage of 100 mg daily. After 3 weeks of therapy, his eosinophilia and myeloid sarcoma completely resolved, and at evaluation after 3 months he had attained bone marrow cytogenetic remission. To our knowledge, this  is the first case of a nonleukemic myeloid sarcoma with the FIP1L1-PDGFRA rearrangement. Despite its aggressive clinical behavior attributed to myeloid sarcoma in general, the presence of PDGFRA rearrangement in this case conferred a high sensitivity to imatinib treatment and a favorable clinical outcome.

 

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[27]

TÍTULO / TITLE:  - Sporadic cardiac myxoma involving all the cardiac chambers.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Circulation. 2013 Jan 29;127(4):e360-1. doi: 10.1161/CIRCULATIONAHA.112.105528.

            ●● Enlace al texto completo (gratuito o de pago) 1161/CIRCULATIONAHA.112.105528

AUTORES / AUTHORS:  - Satish OS; Aditya MS; Rao MA; Mishra RC

INSTITUCIÓN / INSTITUTION:  - Correspondence: Oruganti Sai Satish, DM, Department of Cardiology, Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad-500 082, AndhraPradesh, India. osaisatish@yahoo.com.

 

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[28]

TÍTULO / TITLE:  - Synovial sarcoma of the lung in a patient who received radioactive iodine therapy for thyroid cancer.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Thyroid. 2012 Dec 4.

            ●● Enlace al texto completo (gratuito o de pago) 1089/thy.2012.0472

AUTORES / AUTHORS:  - Vora A; Schneider AB

INSTITUCIÓN / INSTITUTION:  - University of Illinois at Chicago, Section of Endocrinology, Diabetes and metabolism, Chicago, Illinois, United States; Avni_Vora@ghsystem.org.

RESUMEN / SUMMARY:  - Background: Synovial sarcomas are uncommon malignancies that mainly affect adolescents and young adults. Most arise from the deep soft tissues of the extremities, but they can occur in other parts of the body such as the lung. Synovial sarcomas after radiation therapy are rare, in contrast with other sarcomas, with only 6 reported cases. Secondary malignancies after radioactive iodine (RAI) therapy are also uncommon, with the most consistent evidence for hematologic malignancies. Patient findings: We present what we believe to be the  first report of a synovial sarcoma of the lung with an SS18/SSX1 translocation following RAI therapy. At age 20, the patient developed papillary thyroid cancer  and later had two surgically confirmed recurrences. Over the course of her care she received a total of about 220 mCi of 131I. At age 34, as part of an evaluation for another suspected recurrence she had a PET/CT scan and a pulmonary mass was detected. Summary and Conclusion: Although not previously reported, this case suggests that synovial sarcomas may be a secondary malignancy following RAI  therapy. The latency in this case is reasonable, the dose to the lungs was small, but in the range where radiation-related malignancy may occur, and the somatic chromosomal rearrangement could be a radiation effect.

 

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[29]

TÍTULO / TITLE:  - Phase I trial of bortezomib and dacarbazine in melanoma and soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Invest New Drugs. 2013 Jan 13.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10637-012-9913-8

AUTORES / AUTHORS:  - Poklepovic A; Youseffian L; Winning M; Birdsell CA; Crosby NA; Ramakrishnan V; Ernstoff MS; Roberts JD

INSTITUCIÓN / INSTITUTION:  - Massey Cancer Center and the Division of Hematology, Oncology & Palliative Care,  Virginia Commonwealth University, Richmond, VA, 23298-0037, USA.

RESUMEN / SUMMARY:  - Purpose Preclinical studies in human melanoma cell lines and murine xenograft tumor models suggest that the proteasome inhibitor bortezomib enhances the activity of the cytotoxic agent dacarbazine. We performed a phase I trial of bortezomib and dacarbazine in melanoma, soft tissue sarcoma, and amine precursor  uptake and decarboxylation tumors. The primary objective was to identify recommended phase II doses for the combination. Experimental design Bortezomib and dacarbazine were both administered intravenously once weekly. All patients received prophylactic antiemetics. Dose escalation proceeded using a standard 3 + 3 design. Response was assessed according to NCI RECIST v1.0. Results Twenty eight patients were enrolled to six dose levels. Bortezomib 1.6 mg/m(2) and dacarbazine 580 mg/m(2) are the recommended phase II weekly doses. The combination was generally well tolerated. Among 15 patients with melanoma there was one durable complete response in a patient with an exon-11 cKIT mutation, and one partial response. Among 12 patients with soft tissue sarcoma there was one partial response. Conclusions Bortezomib 1.6 mg/m(2) and dacarbazine 580 mg/m(2)  administered intravenously once weekly is well tolerated and has at least minimal activity in melanoma and soft tissue sarcoma.

 

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[30]

TÍTULO / TITLE:  - Complex alternative cytoplasmic protein isoforms of the Kaposi’s sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen 1 (LANA1) generated through non-canonical translation initiation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2012 Dec 19.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.03061-12

AUTORES / AUTHORS:  - Toptan T; Fonseca L; Kwun HJ; Chang Y; Moore PS

INSTITUCIÓN / INSTITUTION:  - Cancer Virology Program, University of Pittsburgh, Pittsburgh, PA, USA.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) protein is constitutively expressed in all KSHV-infected cells as well  as in all forms of KSHV-associated malignancies. LANA1 is a multifunctional KSHV  oncoprotein containing multiple repeat sequences that is important for viral episome maintenance and regulation of cellular and viral gene expression. Here we characterize multiple LANA1 isoforms and show that approximately 50% of LANA1 is  naturally generated as N-terminally truncated shoulder proteins that are detected on SDS-PAGE as faster migrating shoulder bands designated LANA1(S). Higher molecular weight LANA1(S) isoforms initiate downstream at non-canonical sites within the N-terminal region whereas lower molecular weight LANA1(S) isoforms initiate downstream within the central repeat 1 domain. LANA1(S) proteins lack an N-terminal NLS motif and some isoforms differ from full length, canonical LANA1 by localizing to perinuclear and cytoplasmic sites. While LANA1 has until now been assumed to be solely active in the nucleus, this reveals that this major KSHV oncoprotein may have cytoplasmic activities as well. KSHV overcomes its limited genetic coding capacity by generating alternatively initiated protein isoforms that may have distinct biological functions.

 

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[31]

TÍTULO / TITLE:  - A 32-month follow-up study of nanovesicle concentrations in blood from 12 patients with gastrointestinal stromal tumour treated with imatinib.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochem Soc Trans. 2013 Feb 1;41(1):303-8. doi: 10.1042/BST20120247.

            ●● Enlace al texto completo (gratuito o de pago) 1042/BST20120247

AUTORES / AUTHORS:  - Ogorevc E; Stukelj R; Bedina-Zavec A; Sustar V; Simundic M; Kralj-Iglic V; Jansa R

INSTITUCIÓN / INSTITUTION:  - *Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, SI-1000 Ljubljana, Slovenia.

RESUMEN / SUMMARY:  - Clinical studies have indicated that the NV (nanovesicle) concentration in blood  samples is a potential indicator of clinical status and can be used to follow the development of the disease. For 32 months, we monitored the effect of imatinib treatment on NV concentrations in blood samples from 12 patients with GIST (gastrointestinal stromal tumour). The NV concentration before the treatment increased with respect to control by a factor of 3.5 on average (range 2.6-9.2).  The first week after initiation of the treatment, the NV concentration increased  considerably, by a factor of 13 on average (range 5.9-21.2), whereas on average,  after 1 month, it decreased to the level of the control and remained at that level for at least 1.5 years. Recent assessment (after 2.5 years) showed a somewhat increased NV concentration, by a factor of 2 on average (range 0.7-3.9). Low NV concentrations in blood samples during the treatment reflect a favourable  effect of imatinib in these patients and no remission of the disease was hitherto observed.

 

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[32]

TÍTULO / TITLE:  - Human sarcomas are mosaic for telomerase-dependent and telomerase-independent telomere maintenance mechanisms: implications for telomere-based therapies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Pathol. 2013 Jan;182(1):41-8. doi: 10.1016/j.ajpath.2012.10.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ajpath.2012.10.001

AUTORES / AUTHORS:  - Gocha AR; Nuovo G; Iwenofu OH; Groden J

INSTITUCIÓN / INSTITUTION:  - Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University College of Medicine, Columbus, Ohio.

RESUMEN / SUMMARY:  - Telomere shortening necessitates that tumor cells activate a telomere maintenance mechanism (TMM) to support immortalization. Although most tumor cells activate expression of the enzyme telomerase, some cells elongate telomeres in a telomerase-independent manner, termed alternative lengthening of telomeres (ALT). Previous studies have evaluated the presence of telomerase or ALT mechanisms or both in a variety of tumor types. Our studies also show that TMMs are not mutually exclusive in some tumors. In contrast, our IHC analyses of human sarcomas identified a subset of tumors with some cells containing ALT-associated  PML bodies, a hallmark of ALT, and separate cells expressing telomerase in the same tumor. By using a second set of human osteosarcomas, we merged IHC and biochemical analyses to characterize more fully the tumor TMM. The IHC data reveal the presence of both telomerase- and ALT-positive tumor cells in samples that demonstrate characteristics of both telomerase and ALT in biochemical assays. These assays, which measure telomere length and telomerase activity of tumor extracts, are conventionally used to classify tumor TMM. Our results suggest that TMM is not a single or perhaps static characteristic of some tumors  and that TMM heterogeneity should be considered in tumor stratification. Furthermore, clinical interest in telomere-based therapies may necessitate accurate characterization of tumor TMM before treatment to maximize therapeutic efficacy.

 

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[33]

TÍTULO / TITLE:  - Is there a “gold” standard treatment for patients with isolated myeloid sarcoma?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biomed Pharmacother. 2012 Nov 19. pii: S0753-3322(12)00106-0. doi: 10.1016/j.biopha.2012.10.014.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.biopha.2012.10.014

AUTORES / AUTHORS:  - Antic D; Elezovic I; Milic N; Suvajdzic N; Vidovic A; Perunicic M; Djunic I; Mitrovic M; Tomin D

INSTITUCIÓN / INSTITUTION:  - Clinic for hematology, Clinical Center Serbia, Koste Todorovica 2, 11000 Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.  Electronic address: tweety@scnet.rs.

RESUMEN / SUMMARY:  - Isolated myeloid sarcoma is an extramedullary tumor of immature myeloid cells defined by the absence of leukemia history, myelodisplastic syndrome, or myeloproliferative neoplasma with a negative bone marrow biopsy. Myeloid sarcoma  is a very rare condition, and few cases have been reported. We reviewed data of 12 patients with isolated myeloid sarcoma managed at a single center to determine the possible prognostic factors affecting patient survival, such as age, sex, type, localization, and treatment options. Patients were mostly men (n=8), with a median age of 39 years. Patients were initially treated with chemotherapy (n=7) or surgery (n=5). In three patients, hematopoietic stem cell transplantation was  performed. During the follow-up period, nine patients died. The median overall survival was 13 months, while event-free survival was 8 months. Regarding initial treatment strategy, no significant difference in overall survival was observed. Both chemotherapy and hematopoietic stem cell transplantation independently improved event-free survival. In addition, patients who received chemotherapy combined with hematopoietic stem cell transplantation had significantly longer event-free survival than those treated with chemotherapy alone. Age<40 years together with chemotherapy/hematopoietic stem cell transplantation significant affected event-free survival. Based on our results, the treatment of myeloid sarcoma requires a systemic rather than a localized approach with surgery or radiotherapy. While prospective evaluations are needed, chemotherapy with allogenic hematopoietic stem cell transplantation should be considered as the optimal therapy for isolated myeloid sarcoma.

 

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[34]

TÍTULO / TITLE:  - Deep vein thrombosis and pulmonary embolism in a patient affected by uterine fibroids: clinical case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Panminerva Med. 2012 Dec;54(1 Suppl 4):97-9.

AUTORES / AUTHORS:  - Ippolito E; Buora A; Belcaro G; Alari G; Arpaia G; Ciammaichella G

INSTITUCIÓN / INSTITUTION:  - Department of Biomedical Surgery and Odontological Sciences, University of Milan, Milan, Italy.

RESUMEN / SUMMARY:  - A 51 year old woman was admitted for night dyspneic attacks and fainting. When hospitalised the patient reported in the previous 10 days dry cough, edema and pain (left leg). The woman’s medical history did not show any risk factors for vein thromboembolism, d-dimer dosage appeared increased and arterial blood gas showed hypoxemia and hypocapnia. ECG and chest X-Rays were within normal limits;  a chest CT diagnosed pulmonary embolism that was treated with thrombolytic therapy. Venous lower extremity ultrasound detected ilio-femoral and popliteal venous thrombosis and an abdominal CT showed a swollen and fibromatous uterus, obstructing the left iliac vein system. Thrombolytic therapy was effective to for pulmonary embolism and to begin recanalization of the iliac, femoral, and popliteal veins. The patients was sent home in good clinical conditions, with anticoagulant therapy; later the uterine fibroma was treated with hysterectomy.

 

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[35]

TÍTULO / TITLE:  - Radiosurgical treatment of ulnar plexiform neurofibroma in a neurofibromatosis type 1 (NF1) patient.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Neurochir (Wien). 2013 Jan 11.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00701-012-1597-5

AUTORES / AUTHORS:  - Marchetti M; Franzini A; Nazzi V; De Martin E; Fariselli L

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Radiotherapy Unit, Fondazione IRCCS Istituto Neurologico C Besta, Via Celoria 11, 20124, Milan, Italy, marchettimarcello@gmail.com.

 

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[36]

TÍTULO / TITLE:  - An analysis of patient characteristics and clinical outcomes in primary pulmonary sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Thorac Oncol. 2013 Feb;8(2):147-51. doi: 10.1097/JTO.0b013e318277401f.

            ●● Enlace al texto completo (gratuito o de pago) 1097/JTO.0b013e318277401f

AUTORES / AUTHORS:  - Spraker MB; Bair E; Bair R; Connell PP; Mahmood U; Koshy M

INSTITUCIÓN / INSTITUTION:  - *Department of Radiation Oncology, University of Illinois at Chicago, Chicago, Illinois; daggerDepartments of Endodontics and Biostatistics, University of North Carolina, Chapel Hill, North Carolina; double daggerDepartment of Radiation Oncology, University of Chicago, Chicago, Illinois; and section signDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas.

RESUMEN / SUMMARY:  - INTRODUCTION: : Literature concerning primary pulmonary sarcomas (PPS) is limited to small case series. This study examines, in a large cohort, the clinical characteristics and therapeutic strategies of PPS and their impact on overall survival (OS). METHODS: : This was a retrospective analysis from the Surveillance, Epidemiology, and End Results database (1988-2008). Eligible patients had primary PPS and underwent local therapy. Survival estimates were obtained using the Kaplan-Meier method and the Cox regression model. OS of PPS patients were compared with a cohort of 10,909 patients with extremity soft-tissue sarcomas. RESULTS: : The cohort included 365 PPS patients with a median follow-up of 21 months. Fifty-five percent of the patients had large tumors (>5 cm), 76% were high-grade, and 16% had node-positive disease. Seventy-five percent of the cohort underwent surgery alone, 14% underwent surgery and radiation therapy, and 11% underwent radiation therapy alone. Multivariate analysis showed reduced OS for patients with tumors more than 5 cm (hazard ratio  [HR] 1.6, 95% confidence interval [CI] 1.25-2.19), high tumor grade (HR 3.1, 95%  CI 1.26-3.62), and unresectable disease (HR 2.6, 95% CI 1.76-3.88. The 5-year OS  for the cohort of pulmonary sarcomas versus sarcomas of the extremities was 35% versus 71% (p < 0.0001). CONCLUSION: : This large study examining PPS patients reveals a high rate of nodal involvement and a markedly worse OS than patients with extremity soft-tissue sarcomas. Thus, given the poor overall prognosis, it is recommended that PPS patients undergo a thorough mediastinal nodal evaluation  to rule out locoregional metastasis and proceed with aggressive treatment.

 

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[37]

TÍTULO / TITLE:  - Chemotherapy Use in Elderly Patients with Soft Tissue Sarcoma: A Population-based Study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Invest. 2013 Feb;31(2):83-91. doi: 10.3109/07357907.2012.756112. Epub 2013 Jan 15.

            ●● Enlace al texto completo (gratuito o de pago) 3109/07357907.2012.756112

AUTORES / AUTHORS:  - Matushansky I; Dela Cruz F; Insel BJ; Hershman DL; Neugut AI

INSTITUCIÓN / INSTITUTION:  - Departments of Medicine1.

RESUMEN / SUMMARY:  - Adjuvant chemotherapy for soft tissue sarcoma (STS) remains controversial while improvement in survival has never been conclusively demonstrated for metastatic STS. We identified individuals in SEER-Medicare with resected or metastatic STS,  1991-2007. Of 2,382 patients with resected STS, 106 (4.5%) received chemotherapy. High tumor grade, larger tumor size, and malignant fibrous histiocytoma subtype were associated with chemotherapy receipt. Of 365 patients with metastatic STS, 118 (32.4%) received chemotherapy. Younger age, fewer comorbidities, and being married were associated with chemotherapy receipt. Consistent with clinical trials, we found minimal use of chemotherapy. Clinical factors were associated with chemotherapy receipt in nonmetastatic STS.

 

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[38]

TÍTULO / TITLE:  - Angiosarcoma Arising Within a Long-Standing Cystic Lesion of the Adrenal Gland: A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Jan 28.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.44.0800

AUTORES / AUTHORS:  - Sung JY; Ahn S; Kim SJ; Park YS; Choi YL

INSTITUCIÓN / INSTITUTION:  - KyungHee University Medical Center, KyungHee University School of Medicine, Seoul, Korea.

 

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[39]

TÍTULO / TITLE:  - Innate immune defense defines susceptibility of sarcoma cells to measles vaccine  virus based oncolysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Jan 9.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.02106-12

AUTORES / AUTHORS:  - Berchtold S; Lampe J; Weiland T; Smirnow I; Schleicher S; Handgretinger R; Kopp HG; Reiser J; Stubenrauch F; Malek NP; Bitzer M; Lauer UM

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine I, University Hospital Tubingen, Otfried-Muller-Str. 10, D-72076 Tubingen.

RESUMEN / SUMMARY:  - The oncolytic potential of measles vaccine virus (MeV) has been demonstrated in several tumor entities. Here, we investigated the susceptibility of eight sarcoma cell lines to MeV-mediated oncolysis and found five to be susceptible whereas three proved to be resistant. In the MeV resistant cell lines, we often observed  an inhibition of viral replication going along with a strong upregulation of the  intracellular virus sensing molecule RIG-I and of the interferon (IFN)-stimulated gene IFIT1. Not only expression of IFIT1 but also phosphorylation of IFN-stimulated Stat1 took place rapidly and were found to be persistent over time. In contrast, susceptible cell lines showed a much weaker, delayed or completely missing expression of IFIT1 as well as a delayed or only transient phosphorylation of Stat1, whereas exogenic stimulation with interferon beta (IFN-beta) resulted in a comparable profound activation of Stat1 and expression of IFIT1 in all cell lines. Pretreatment with IFN-beta rendered three of the susceptible cell lines more resistant to MeV-mediated oncolysis. These data suggest that differences in the innate immune defense often account for different degrees of susceptibility of sarcoma cell lines to MeV-mediated oncolysis. In a therapeutic perspective, we were able to overcome resistance to MeV by increasing the multiplicity of infection (MOI) and by addition of the prodrug 5-fluorocytosine (FC) thereby exploiting the suicide gene function of virotherapeutic vector MeV-SCD armed with the SCD fusion protein consisting of yeast cytosine deaminase and yeast uracil phosphoribosyltransferase.

 

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[40]

TÍTULO / TITLE:  - Oncological outcome of patients with deeply located soft tissue sarcoma of the pelvis: A follow up study at minimum 5 years after diagnosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Surg Oncol. 2013 Jan 21. pii: S0748-7983(12)01378-9. doi: 10.1016/j.ejso.2012.12.019.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejso.2012.12.019

AUTORES / AUTHORS:  - Nakamura T; Abudu A; Murata H; Grimer RJ; Carter SR; Tillman RM; Jeys L

INSTITUCIÓN / INSTITUTION:  - Oncology Service, The Royal Orthopaedic Hospital, Bristol Road South, Northfield, Birmingham B31 2AP, UK; Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu-city, Mie 514-8507, Japan.

RESUMEN / SUMMARY:  - AIMS: The treatment of pelvic soft tissue sarcomas (STS) presents one of the most challenging problems in musculoskeletal oncology because of the complex anatomy of the pelvis, late diagnosis and large tumor size. Our study was designed to determine the outcome and prognostic factors for survival and local recurrence in patients with pelvic STS located deep to the fascia and deemed suitable for curative surgical treatment. PATIENTS AND METHODS: Ninety consecutive pelvic STS  patients with at least 5-year possible follow-up from diagnosis were studied. Mean age at diagnosis was 54 years. Mean follow-up and tumor size were 69 months  and 13cm, respectively. Histological grades were grade 3 in 51, grade 2 in 22 and grade 1 in 17 patients. Tumor locations were extra-pelvic or outside pelvic brim  (n=67), intra-pelvic or within pelvic brim (n=10), and combined or involving both outside and within pelvic brim (n=13). RESULT: Surgical treatment was excision in 84 patients and hindquarter amputation in 6 patients. In 84 patients who underwent excision, surgical margin was wide in 21 patients, marginal in 33, and  intralesional in 30. Radiotherapy was used for all high grade tumors. Disease-specific survival was 53.3% at 5 years. Local recurrence occurred in 23%. Development of local recurrence was related to surgical margin (p=0.03). Local recurrence, tumor histological grade and metastasis at diagnosis independently influenced disease-specific survival (p=0.0008, p<0.0001, p=0.02, respectively).  CONCLUSION: The patients with high grade tumors and positive surgical margins represent a particular group with high risk of local recurrence even with radiotherapy.

 

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[41]

TÍTULO / TITLE:  - Hepatic angiosarcoma: cross-sectional imaging findings in seven patients with emphasis on dynamic contrast-enhanced and diffusion-weighted MRI.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Abdom Imaging. 2012 Dec 8.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00261-012-9967-2

AUTORES / AUTHORS:  - Bruegel M; Muenzel D; Waldt S; Specht K; Rummeny EJ

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str. 22, 81675, Munich, Germany, melanie.bruegel@tum.de.

RESUMEN / SUMMARY:  - OBJECTIVE: Primary hepatic angiosarcoma is a very rare and aggressive malignancy  of vascular origin. We describe cross-sectional imaging findings of this entity with emphasis on dynamic contrast-enhanced (DCE) and diffusion-weighted (DWI) MR  imaging. METHODS: Seven cases of pathologically confirmed hepatic angiosarcoma were retrospectively reviewed (CT and MRI examinations were available in seven and six patients, respectively). Two radiologists evaluated lesion growth patterns, attenuation, signal intensity characteristics, contrast enhancement patterns, and apparent diffusion coefficients (ADCs). RESULTS: Multifocal hepatic disease was present in six patients by means of a mixed pattern of large dominant masses and multiple small nodules; one patient had a solitary large mass. Unenhanced images depicted hemorrhagic areas and a markedly heterogeneous internal architecture within large tumors. Contrast-enhanced early phase images showed variable patterns including patchy peripheral or bizarre shaped intralesional foci of enhancement, peripheral rim enhancement, and small lesions  without enhancement. On DCE images, the majority of lesions presented with varying degrees of progressive enhancement. Small nodules frequently displayed homogeneous enhancement on delayed phase images due to complete fill-in. DWI revealed a high interlesional variability of ADC values (range 0.57-2.41 x 10(-3  )mm(2)/s, mean 1.37 x 10(-3 )mm(2)/s). CONCLUSION: Cross-sectional imaging findings of hepatic angiosarcoma reflect the varied histopathological composition of the tumors. Multifocal disease, hemorrhage within large lesions, as well as progressive enhancement on DCE images are typical features of hepatic angiosarcoma. The mean ADC of lesions was found to be slightly elevated in comparison with other hepatic malignancies.

 

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[42]

TÍTULO / TITLE:  - Kaposi’s sarcoma-associated herpesvirus lana2 protein interacts with the pocket proteins and inhibits their sumoylation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncogene. 2013 Jan 14. doi: 10.1038/onc.2012.603.

            ●● Enlace al texto completo (gratuito o de pago) 1038/onc.2012.603

AUTORES / AUTHORS:  - Marcos-Villar L; Gallego P; Munoz-Fontela C; de la Cruz-Herrera CF; Campagna M; Gonzalez D; Lopitz-Otsoa F; Rodriguez MS; Rivas C

INSTITUCIÓN / INSTITUTION:  - Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma de Madrid, Madrid, España.

RESUMEN / SUMMARY:  - The pocket proteins retinoblastoma protein (pRb), p107 and p130 are the key targets of oncoproteins expressed by DNA tumor viruses. Some of these viral proteins contain an LXCXE motif that mediates the interaction with the three pocket proteins and the inhibition of the pRb SUMOylation. Kaposi’s sarcoma herpesvirus (KSHV) contains at least two proteins that can regulate pRb function  but, so far, a KSHV-encoded protein targeting p107 and p130 has not been identified. Here, we show that the KSHV latent protein LANA2 binds to pRb, p107 and p130. LANA2 contains an LXCXE motif that is required for bypassing pRb-mediated cell-cycle arrest and for inhibiting pRb SUMOylation. Finally, we demonstrate that, in addition to pRb, both p107 and p130 can be SUMOylated, and this modification is also inhibited by LANA2 in an LXCXE-dependent manner. These  results demonstrate, for the first time, the SUMOylation of p107 or p130 and, so  far, they represent the first example of a KSHV protein able to interact with the three pocket proteins and to inhibit their conjugation to SUMO.Oncogene advance online publication, 14 January 2013; doi:10.1038/onc.2012.603.

 

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[43]

TÍTULO / TITLE:  - Evaluation of symptomatic uterine fibroids in candidates for uterine artery embolization: comparison between ultrasonographic and MR imaging findings in 68 consecutive patients.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Jan-Feb;37(1):83-90. doi: 10.1016/j.clinimag.2012.03.007. Epub 2012 Jun 8.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.03.007

AUTORES / AUTHORS:  - Malartic C; Morel O; Rivain AL; Place V; Le Dref O; Dohan A; Gayat E; Barranger E; Soyer P

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Hopital Lariboisiere-APHP and Universite Diderot-Paris 7, 2 rue Ambroise Pare, 75010 Paris, France.

RESUMEN / SUMMARY:  - Ultrasonographic and magnetic resonance (MR) imaging examinations of 68 women with uterine fibroids were reviewed to determine whether MR imaging may alter the therapeutic approach based on ultrasonography alone before uterine embolization.  Therapeutic decisions based on ultrasonography alone were compared to those obtained after MR imaging. Discordant findings between both examinations involved 51 women (75%), and 19 (28%) had their therapeutic approaches based on ultrasonography alone altered by MR imaging. Ultrasonography and MR imaging showed concordant findings in 17 women (25%) for whom no changes in therapeutic option were made. MR imaging alters the therapeutic approach based on ultrasonography alone in 28% of candidates for uterine artery embolization.

 

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[44]

TÍTULO / TITLE:  - Genetic Profiling Identifies Two Classes of Soft-Tissue Leiomyosarcomas with Distinct Clinical Characteristics.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Cancer Res. 2013 Jan 17.

            ●● Enlace al texto completo (gratuito o de pago) 1158/1078-0432.CCR-12-2970

AUTORES / AUTHORS:  - Italiano A; Largarde P; Brulard C; Terrier P; Lae M; Marques B; Ranchere-Vince D; Michels JJ; Trassard M; Cioffi A; Piperno-Neumann S; Chevreau C; Blay JY; Delcambre C; Isambert N; Penel N; Bay JO; Bonvalot S; Le Cesne A; Coindre JM; Chibon F

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Institut Bergonie.

RESUMEN / SUMMARY:  - PURPOSE: Data regarding the prognostic factors of soft-tissue leiomyosarcomas (LMS) and their correlation with molecular profile are limited. Study design: From 1990 to 2010, 586 adult patients with a primary soft-tissue LMS were included in the French Sarcoma Group (GSF) database after surgery of the primary  tumor. Multivariate analyses were carried out by Cox’s regression model in a backward stepwise procedure. Genetic profiling was performed for 73 cases. RESULTS: Median age was 59 years (range 21-98). The median follow-up of patients  alive was 46 months. The 5-year metastasis-free survival (MFS) rate was 51% (95%  location, and grade > 1 were independent adverse prognostic factors for MFS. The  5-year overall survival rate was 63% (95% CI 59-67). On multivariate analysis, age >/= 60 years old, tumor size > 5 cm, deep location, and grade > 1 were independent adverse prognostic factors for OS. Molecular profiling identified specific clusters with activation of different biological pathways: retroperitoneal LMS are characterized by overexpression of genes involved in muscle differentiation and non-retroperitoneal LMS characterized by overexpression of genes mainly involved in extracellular matrix, wounding and adhesion pathways. The CINSARC signature but not CGH profiling was predictive of  outcome. CONCLUSION: Soft-tissue LMS represent a heterogeneous group of tumors with at least two categories retroperitoneal and extremities LMS having specific  clinical outcome and molecular features. Future clinical trials should consider this heterogeneity for a better stratification of patients.

 

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[45]

TÍTULO / TITLE:  - Dedifferentiation in Gastrointestinal Stromal Tumor to an Anaplastic KIT-negative Phenotype: A Diagnostic Pitfall: Morphologic and Molecular Characterization of 8  Cases Occurring Either De Novo or After Imatinib Therapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2013 Jan 22.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e31826c1761

AUTORES / AUTHORS:  - Antonescu CR; Romeo S; Zhang L; Nafa K; Hornick JL; Nielsen GP; Mino-Kenudson M; Huang HY; Mosquera JM; Tos PA; Fletcher CD

INSTITUCIÓN / INSTITUTION:  - *Department of Pathology, Memorial Sloan-Kettering Cancer Center paragraph signWeill Medical College of Cornell University, New York, NY double daggerSurgical Pathology, Brigham & Women’s Hospital section signMassachusetts General Hospital, Boston, MA daggerTreviso General Hospital, Treviso, Italy parallelKaohsiung Chang Gung Memorial Hospital and Chang Gung University College  of Medicine, Kaohsiung, Taiwan, Republic of China.

RESUMEN / SUMMARY:  - Most gastrointestinal stromal tumors (GISTs) can be recognized by their monotonous cytologic features and overexpression of KIT oncoprotein. Altered morphology and loss of CD117 reactivity has been described previously after chronic imatinib treatment; however, this phenomenon has not been reported in imatinib-naive tumors. Eight patients with abrupt transition from a classic CD117-positive spindle cell GIST to an anaplastic CD117-negative tumor were investigated for underlying molecular mechanisms of tumor progression. Pathologic and molecular analysis was performed on each of the 2 components. Genomic DNA polymerase chain reaction for KIT, PDGFRA, BRAF, and KRAS hot spot mutations and  fluorescence in situ hybridization for detecting KIT gene copy number alterations were performed. TP53 mutational analysis was performed in 5 cases. There were 7 men and 1 woman, with an age range of 23 to 65 years. Five of the primary tumors  were located in the stomach, and 1 case each originated in the small bowel, colon, and rectum. In 3 patients, the dedifferentiated component occurred in the  setting of imatinib resistance, whereas the remaining 5 occurred de novo. The dedifferentiated component had an anaplastic appearance, including 1 angiosarcomatous phenotype, with high mitotic activity and necrosis, and showed complete loss of CD117 (8/8) and CD34 (5/8) expression and de novo expression of  either cytokeratin (4/8) or desmin (1/8). There was no difference in the KIT genotype between the 2 components. However, 2 imatinib-resistant tumors showed coexistence of KIT exon 11 and exon 13 mutations. Fluorescence in situ hybridization showed loss of 1 KIT gene in 3 cases and low-level amplification of KIT in 2 other cases in the CD117-negative component, compared with the CD117-positive area. TP53 mutation was identified in 1/5 cases tested, being present in both components. In summary, dedifferentiation in GIST may occur either de novo or after chronic imatinib exposure and can represent a diagnostic  pitfall. This phenomenon is not related to additional KIT mutations, but might be secondary to genetic instability, either represented by loss of heterozygosity or low level of KIT amplification.

 

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[46]

TÍTULO / TITLE:  - Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anticancer Drugs. 2013 Mar;24(3):278-90. doi: 10.1097/CAD.0b013e32835cbde7.

            ●● Enlace al texto completo (gratuito o de pago) 1097/CAD.0b013e32835cbde7

AUTORES / AUTHORS:  - Park H; Drevelle O; Daviau A; Senta H; Bergeron E; Faucheux N

INSTITUCIÓN / INSTITUTION:  - aDepartment of Chemical Engineering and Biotechnological Engineering, Laboratory  of Cell-Biomaterial Biohybrid Systems, University of Sherbrooke bEtienne LeBel Clinical Research Center, Sherbrooke University Hospital Centre (CHUS), Sherbrooke cDepartment of Physics Engineering, Laboratory of Laser Processing and Plasmonics, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada.

RESUMEN / SUMMARY:  - It was recently suggested that bone morphogenetic protein (BMP)-2 may be useful for treating osteosarcoma cells. BMP-9, which has been patented to treat breast and prostate cancers, has a higher osteoinductive potential than BMP-2. Peptides  derived from the knuckle epitope of BMPs (pBMPs) also induced osteogenic differentiation. However, the effect of BMP-9 and pBMPs on osteosarcoma cells is  unclear. We analyzed the effects of BMP-2, BMP-9, pBMP-2, and pBMP-9 on the behavior of human MG-63 and SaOS-2 osteosarcoma cells. An inhibitor of MEK1 activation (PD98059) that prevents downstream extracellular signal-regulated kinase ½ (ERK1/2) phosphorylation and a specific inhibitor of p38 were also used as mitogen activated protein kinase-targeting therapy is being investigated  as a treatment modality for osteosarcoma. BMP-2 and BMP-9 (1.92 nmol/l) induced the phosphorylation of Smad1/5/8 in both osteosarcoma cells within 1 h but had different effects on mitogen activated protein kinase pathways. Whereas BMP-2 mainly activated ERK1/2, BMP-9 phosphorylated p38 within 1 h. pBMP-2 did not activate either the Smad or ERK/p38, whereas pBMP-9, like BMP-9, induced both Smad1/5/8 and p38 phosphorylation. p38 activation by BMP-9 or pBMP-9 was also enhanced by PD98059. However, BMP-2 or BMP-9 increased the amounts of distal-less homeobox 5 and Osterix mRNAs in SaOS-2 cells within 6 h, whereas pBMP-9 had no effect. PD98059 promoted the highest level of Osterix mRNA in SaOS-2 cells incubated with BMP-2 or BMP-9, whereas p38 inhibitor had no effect. Furthermore,  PD98059 induced the lowest proliferation of MG-63 cells incubated with BMP-2, whereas p38 inhibitor did not affect the proliferation of either osteosarcoma cell line. Therefore a combination of BMP-2 or BMP-9 and an inhibitor of MEK1 may be a promising tool for regulating osteosarcoma cell behavior.

 

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[47]

TÍTULO / TITLE:  - Multimodality Management of Metastatic Patients With Soft Tissue Sarcomas May Prolong Survival.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Clin Oncol. 2012 Dec 27.

            ●● Enlace al texto completo (gratuito o de pago) 1097/COC.0b013e318277d7e5

AUTORES / AUTHORS:  - Bedi M; King DM; Charlson J; Whitfield R; Hackbarth DA; Zambrano EV; Wang D

INSTITUCIÓN / INSTITUTION:  - Departments of *Radiation Oncology daggerOrthopaedic Surgery double daggerMedical Oncology section signPlastic Surgery parallelPathology, Medical College of Wisconsin, Milwaukee, WI.

RESUMEN / SUMMARY:  - OBJECTIVES:: Patients who develop metastatic disease from soft tissue sarcoma have a poor prognosis. The purpose of this study was to identify metastatic survival rates and identify prognostic variables that predict for these outcomes. METHODS:: Between 2000 and 2010, 182 patients with stage I to IV primary soft tissue sarcomas of the extremity and trunk were treated with multimodality treatment. Fifty-five patients developed or presented with metastasis. We retrospectively analyzed prognostic factors for metastatic survival. Metastatic survival between groups was compared with the log-rank test. Survival curves were estimated by Kaplan-Meier plots. Multivariate analysis was performed using the Cox proportional hazards model. RESULTS:: Median follow-up was 3.1 years. Median  metastatic survival was 24.2 months. Median metastatic survival in those undergoing multimodality therapies was 40 versus 22 months in those receiving single modality treatments. In single predictor Cox models, age, stage, number of lung metastases, location of metastases, and primary disease were significant for metastatic survival. On multivariate analysis, number of pulmonary metastases, histology, stage, and location of primary disease predicted for metastatic survival. Patients who had pulmonary-only disease had improved metastatic survival versus those that had extrapulmonary with or without pulmonary metastatic disease (38 vs. 15 mo). Patients who had </=5 pulmonary metastasis had improved metastatic survival versus those that had >5 pulmonary lesions (55 vs. 22 mo). CONCLUSIONS:: This analysis shows that >5 pulmonary metastasis, malignant fibrous histiocytoma histology, stage III disease, and proximal lower extremity sarcomas are associated with decreased metastatic survival. Moreover, aggressive  multimodality management of metastatic disease may prolong metastatic survival.

 

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[48]

TÍTULO / TITLE:  - Inflammatory Myofibroblastic Tumor of the Colon.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Jan 28.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.42.8961

AUTORES / AUTHORS:  - Gurzu S; Bara T; Jung I

INSTITUCIÓN / INSTITUTION:  - University of Medicine and Pharmacy of Targu-Mures, Targu Mures, Romania.

 

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[49]

TÍTULO / TITLE:  - Refractory Hypoglycemia Controlled by Sorefenib in Solitary Fibrous Tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Jan 22.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2011.40.7999

AUTORES / AUTHORS:  - Le Jeune S; Des Guetz G; Bihan H; Cohen R; Coindre JM; Mourad JJ

INSTITUCIÓN / INSTITUTION:  - Avicenne University Hospital, Assistance Publique-Hopitaux de Paris, Bobigny, France.

 

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[50]

TÍTULO / TITLE:  - Embryonal rhabdomyosarcoma of the uterine corpus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Oncol. 2013 Feb 1;31(4):e48-50. doi: 10.1200/JCO.2012.43.1841. Epub 2012 Dec 17.

            ●● Enlace al texto completo (gratuito o de pago) 1200/JCO.2012.43.1841

AUTORES / AUTHORS:  - Garrett LA; Harmon DC; Schorge JO

INSTITUCIÓN / INSTITUTION:  - Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, 55 Fruit St, Yawkey 9 E Boston, Massachusetts 02114; jschorge@partners.org.

 

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[51]

TÍTULO / TITLE:  - Distinct Effects of Ligand-Induced PDGFRalpha and PDGFRbeta Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Res. 2013 Jan 21.

            ●● Enlace al texto completo (gratuito o de pago) 1158/0008-5472.CAN-12-1646

AUTORES / AUTHORS:  - Ehnman M; Missiaglia E; Folestad E; Selfe J; Strell C; Thway K; Brodin B; Pietras K; Shipley J; Ostman A; Eriksson U

INSTITUCIÓN / INSTITUTION:  - Department of Medical Biochemistry and Biophysics, Karolinska Institutet.

RESUMEN / SUMMARY:  - Platelet-derived growth factor receptor (PDGFR) alpha and beta have been suggested as potential targets for treatment of rhabdomyosarcoma, the most common soft tissue sarcoma in children. This study identifies biological activities linked to PDGF signaling in rhabdomyosarcoma models and human sample collections. Analysis of gene expression profiles of 101 primary human rhabdomyosarcomas revealed elevated PDGF-C and -D expression in all subtypes, with PDGF-D as the solely over-expressed PDGFRbeta ligand. By immunohistochemistry, PDGF-CC, PDGF-DD and PDGFRalpha were found in tumor cells, whereas PDGFRbeta was primarily detected in vascular stroma. These results are concordant with the biological processes and pathways identified by data mining. While PDGF-CC/PDGFRalpha signaling associated with genes involved in the reactivation of developmental programs, PDGFDD/PDGFRbeta signaling related to wound healing and leukocyte differentiation. Clinicopathological correlations further identified associations between PDGFRbeta in vascular stroma and the alveolar subtype and with presence of metastases. Functional validation of our findings was carried out in molecularly distinct model systems, where therapeutic targeting reduced tumor burden in a PDGFR-dependent manner with effects on cell proliferation, vessel density and macrophage infiltration. The PDGFR-selective inhibitor CP-673,451 regulated cell proliferation through mechanisms involving reduced phosphorylation of GSK-3alpha and GSK-3beta. Additional tissue culture studies demonstrated a PDGFR-dependent regulation of rhabdosphere formation/cancer cell stemness, differentiation, senescence and apoptosis. In summary, the study demonstrates a clinically relevant distinction in PDGF signaling in human rhabdomyosarcoma and also suggests continued exploration of the influence of stromal PDGFRs on sarcoma progression.

 

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[52]

TÍTULO / TITLE:  - Angiosarcoma in a patient with congenital nonhereditary lymphedema.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cutis. 2012 Nov;90(5):248-51.

AUTORES / AUTHORS:  - Shon W; Wada DA; Folpe AL; Pittelkow MR

INSTITUCIÓN / INSTITUTION:  - Divison of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

RESUMEN / SUMMARY:  - Angiosarcoma is an uncommon but aggressive tumor of endothelial origin that may occur in the upper extremities of patients with postmastectomy lymphedema (Stewart-Treves syndrome) as well as in other regions. We present an unusual case of angiosarcoma associated with congenital nonhereditary lymphedema in an 18-year-old man. Our case underscores the need for a careful clinical examination and shows the importance of appropriate sampling and thorough pathologic examination of suspicious areas to exclude the presence of a malignant process.

 

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[53]

TÍTULO / TITLE:  - Wilms’ Tumor 1 Protein and Estrogen Receptor Beta Expression are Associated with  Poor Outcomes in Uterine Carcinosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Surg Oncol. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1245/s10434-012-2838-9

AUTORES / AUTHORS:  - Guntupalli SR; Cao D; Shroff R; Gao F; Menias C; Stewart Massad L; Powell MA; Mutch DG; Thaker PH

INSTITUCIÓN / INSTITUTION:  - Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado School of Medicine at Denver, Denver, CO, USA, saketh.guntupalli@ucdenver.edu.

RESUMEN / SUMMARY:  - BACKGROUND: Uterine carcinosarcoma (CS) is an aggressive malignancy. Increased expression of Wilms’ tumor 1 (WT1) protein and estrogen receptor beta (ER-beta) protein is associated with worse outcomes in gynecologic cancers; therefore, we sought to assess this association in CS patients. METHODS: A retrospective analysis was conducted for women diagnosed with uterine CS from departmental databases. WT1/ER-beta expression was determined by immunohistochemical staining  and scoring of specimens. Univariate and multivariate models were used to correlate progression-free survival (PFS) and overall survival (OS) with WT1/ER-beta expression and clinicopathologic factors. RESULTS: Ninety four patients had mean follow-up of 27 months. Postoperative treatments included chemotherapy for 52 (55 %) subjects and radiotherapy for 25 (27 %). Sixty-four (68 %) and 74 (79 %) tumor samples expressed WT1 and ER-beta by immunohistochemistry, respectively. On univariate analysis, stage (p = .02) and lower uterine segment invasion (LUSI) (p = .001) were associated with decreased PFS. Only stage (p = .003) was linked to OS. In the total sample, increased WT1 expression was marginally associated with impaired PFS (p = .07) and OS (p = .09) but ER-beta expression was not associated with PFS (p = .89) or OS (p = .30). WT1 and ER-beta concurrent expression was associated with impaired OS (p = .02) and PFS (p = .02). On multivariate analysis, LUSI was a significant prognostic factor for PFS [hazard ratio (HR) 2.21, 95 % confidence interval (CI) = 1.12-4.32, p = .03] and stage for OS (HR 3.20, 95 % CI = 1.23-8.35, p = .02). Increased WT1/ER-beta expression was associated with impaired OS (HR 1.31, 95 % CI = 1.02-1.69, p = .04). CONCLUSIONS: Concurrent increased WT1 and ER-beta expression impairs prognosis for women with uterine CS. Further research is warranted to define how relevant pathways interact and whether targeting these pathways improves OS.

 

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[54]

TÍTULO / TITLE:  - Elevated expression of adrenomedullin is correlated with prognosis and disease severity in osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Mar;30(1):347. doi: 10.1007/s12032-012-0347-0. Epub 2012 Dec 27.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-012-0347-0

AUTORES / AUTHORS:  - Dai X; Ma W; He XJ; Jha RK

INSTITUCIÓN / INSTITUTION:  - Second Department of Orthopedic Surgery, Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, 157 West Five Road, Xi’an, 710004, Shaanxi, China.

RESUMEN / SUMMARY:  - The treatment for osteosarcoma is a formidable challenge. Currently, treatment is not sufficiently effective, and new therapeutic targets are urgently needed. The  aim of this study is to determine the expression of adrenomedullin (ADM) in human osteosarcoma tissue and to assess its effect on the proliferation of MG-63 cells  and in vivo in an animal model of osteosarcoma. First, we collected clinical specimens from osteosarcoma patients and healthy controls and measured ADM expression by immunohistochemistry, RT-PCR, and radioimmunoassay. We also analyzed clinical data to investigate the relationship between ADM expression, malignancy, and tumor prognosis. Based on these data, we used RNA interference (RNAi) against ADM delivered by lentivirus vector transfected into the osteosarcoma cell line MG-63 to downregulate the expression of ADM. Finally, we observed the effect of ADM on the proliferation of MG-63 cells in vitro, and in vivo, in an animal model of osteosarcoma. We found that ADM was overexpressed in  human osteosarcoma tissue, whereas expression was low in the adjacent tissue and  little expression was observed in normal tissue. ADM RNAi significantly inhibited the proliferation of MG-63 cells. Therefore, the growth of osteosarcoma could be  inhibited by decreasing the expression of ADM. Thus, we conclude that ADM expression is highly correlated with the degree of malignancy and metastasis of osteosarcoma.

 

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[55]

TÍTULO / TITLE:  - The Kaposi’s Sarcoma-Associated Herpesvirus ORF34 Protein Binds to HIF-1alpha and Causes Its Degradation via the Proteasome Pathway.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Feb;87(4):2164-73. doi: 10.1128/JVI.02460-12. Epub 2012 Dec 5.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.02460-12

AUTORES / AUTHORS:  - Haque M; Kousoulas KG

INSTITUCIÓN / INSTITUTION:  - Division of Biotechnology and Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi’s sarcoma (KS) and two other lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman’s disease (MCD). Kaposi’s sarcoma is a highly vascular tumor, and recently both hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha were detected in KS samples, indicating a role of HIFs in the KSHV life cycle. Previously, we showed that ORF34, a lytic gene of unassigned function, was activated by hypoxia and that ORF34 transcription was upregulated by both HIFs (M. Haque, D. A. Davis, V. Wang, I. Widmer, and R. Yarchoan, J Virol. 77:6761-6768, 2003). In the present study, we show that coexpression of ORF34 with HIF-1alpham (degradation-resistant HIF-1alpha) caused  substantial reduction in HIF-1alpha-dependent transcription, as evidenced by reporter assays. Two-way immunoprecipitation experiments revealed that ORF34 physically interacted with HIF-1alpham in transient expression experiments. Deletion analysis revealed that three different ORF34 domains interacted with the amino-terminal domain of HIF-1alpha. Also, purified HIF-1alpha and ORF34 proteins interacted with each other. The observed transcriptional inhibition of HIF-1alpha-dependent promoters was attributed to degradation of HIF-1alpha after  binding with ORF34, since the overall amount of wild-type HIF-1alpha but not the  degradation-resistant one (HIF-1alpham) was reduced in the presence of ORF34. Moreover, ORF34 caused degradation of HIF-1alpha in a dose-dependent manner. Inhibition of the ubiquitin-dependent pathway by the chemical proteasome inhibitor MG132 prevented HIF-1alpha degradation in the presence of ORF34. These  results show that ORF34 binds to HIF-1alpha, leading to its degradation via the proteasome-dependent pathway.

 

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[56]

TÍTULO / TITLE:  - DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Res. 2013 Jan 15;73(2):967-977. Epub 2012 Nov 30.

            ●● Enlace al texto completo (gratuito o de pago) 1158/0008-5472.CAN-12-1492

AUTORES / AUTHORS:  - Hauer K; Calzada-Wack J; Steiger K; Grunewald TG; Baumhoer D; Plehm S; Buch T; da Costa OP; Esposito I; Burdach S; Richter GH

INSTITUCIÓN / INSTITUTION:  - Authors’ Affiliations: Children’s Cancer Research Center and Department of Pediatrics, Roman Herzog Comprehensive Cancer Research Center and Klinikum rechts der Isar, Institute for Medical Microbiology, Immunology and Hygiene, Institute of Pathology, Technische Universitat Munchen, Munich; Institute of Pathology, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany; and Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, Basel, Switzerland.

RESUMEN / SUMMARY:  - Ewing sarcoma, an osteolytic malignancy that mainly affects children and young adults, is characterized by early metastasis to lung and bone. In this study, we  identified the pro-metastatic gene DKK2 as a highly overexpressed gene in Ewing sarcoma compared with corresponding normal tissues. Using RNA interference, we showed that DKK2 was critical for malignant cell outgrowth in vitro and in an orthotopic xenograft mouse model in vivo. Analysis of invasion potential in both  settings revealed a strong correlation of DKK2 expression to Ewing sarcoma invasiveness that may be mediated by the DKK effector matrix metalloproteinase 1  (MMP1). Furthermore, gene expression analyses established the ability of DKK2 to  differentially regulate genes such as CXCR4, PTHrP, RUNX2, and TGFbeta1 that are  associated with homing, invasion, and growth of cancer cells in bone tissue as well as genes important for osteolysis, including HIF1alpha, JAG1, IL6, and VEGF. DKK2 promoted bone infiltration and osteolysis in vivo and further analyses defined DKK2 as a key factor in osteotropic malignancy. Interestingly, in Ewing sarcoma cells, DKK2 suppression simultaneously increased the potential for neuronal differentiation while decreasing chondrogenic and osteogenic differentiation. Our results provide strong evidence that DKK2 is a key player in Ewing sarcoma invasion and osteolysis and also in the differential phenotype of Ewing sarcoma cells. Cancer Res; 73(2); 967-77. ©2012 AACR.

 

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[57]

TÍTULO / TITLE:  - Identification of target genes of synovial sarcoma-associated fusion oncoprotein  using human pluripotent stem cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochem Biophys Res Commun. 2013 Jan 10. pii: S0006-291X(13)00039-9. doi: 10.1016/j.bbrc.2013.01.003.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bbrc.2013.01.003

AUTORES / AUTHORS:  - Hayakawa K; Ikeya M; Fukuta M; Woltjen K; Tamaki S; Takahara N; Kato T Jr; Sato S; Otsuka T; Toguchida J

INSTITUCIÓN / INSTITUTION:  - Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Cell Growth and Differentiation, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

RESUMEN / SUMMARY:  - Synovial sarcoma (SS) is a malignant soft tissue tumor harboring chromosomal translocation t(X; 18)(p11.2; q11.2), which produces SS-specific fusion gene, SYT-SSX. Although precise function of SYT-SSX remains to be investigated, accumulating evidences suggest its role in gene regulation via epigenetic mechanisms, and the product of SYT-SSX target genes may serve as biomarkers of SS. Lack of knowledge about the cell-of-origin of SS, however, has placed obstacle in the way of target identification. Here we report a novel approach to  identify SYT-SSX2 target genes using human pluripotent stem cells (hPSCs) containing the doxycycline-inducible SYT-SSX2 gene. SYT-SSX2 was efficiently induced both at mRNA and protein level within three hours after doxycycline administration, while no morphological change of hPSCs was observed until 24h. Serial microarray analyses identified genes of which the expression level changed more than twofold within 24h. Surprisingly, the majority (297/312, 95.2%) was up-regulated gene and this result is against with current concept of SYT-SSX as transcriptional repressor. Comparing these genes with SS-related genes which were selected by a series of in silico analyses, 49 and 2 genes were finally identified as candidates of up- and down-regulated target of SYT-SSX, respectively. Association of these genes with SYT-SSX in SS cells was confirmed by knockdown experiments. Expression profile of SS-related genes in hPSCs and human mesenchymal stem cells (hMSCs) was strikingly different in response to the  induction of SYT-SSX, and more than half of SYT-SSX target genes in hPSCs were not induced in hMSCs. These results suggest the importance of cellular context for correct understanding of SYT-SSX function, and our new system will help to overcome this issue.

 

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[58]

TÍTULO / TITLE:  - PDGFB rearrangement in dermatofibrosarcoma protuberans: correlation with clinicopathologic characteristics and clinical implications.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Jan 21. pii: S0046-8177(12)00399-1. doi: 10.1016/j.humpath.2012.09.021.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.09.021

AUTORES / AUTHORS:  - Ha SY; Lee SE; Kwon MJ; Kim YJ; Lee EH; Seo J; Jang KT; Lee J; Choi YL

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 135-070 Korea.

RESUMEN / SUMMARY:  - Dermatofibrosarcoma protuberans (DFSP) is characterized genetically by the translocation t(17;22)(q22;q13), which creates a COL1A1/PDGFB fusion gene. The implications of this gene for the clinicopathologic features of the disease are not fully understood. Fifty-one cases of DFSP from 46 patients were reclassified  as DFSP (n=29) and DFSP-fibrosarcomatous variant (DFSP-FS; n=22). Fluorescence in situ hybridization was performed using a dual-color break-apart probe to detect rearrangements involving PDGFB, and CD34 immunohistochemistry staining was done.  The DFSP-FS was found in older patients, and the tumors were larger, with a smaller mean area of staining for CD34. PDGFB rearrangement was found in 45 cases (95.7%). The mean gene copy number was 3.82 (range 2.2-6.45) and was higher in DFSP-FS than in classic DFSP (4.54 vs. 3.47; P < .001). The PDGFB copy number showed a moderate positive correlation with the number of mitotic figures and tumor size. Patients undergoing wide excision or having no involvement of the resection margin had no relapses. These results suggest a role for COL1A1/PDGFB in sarcomatous change in DFSP over time. Detection of COL1A1/PDGFB rearrangement  by fluorescence in situ hybridization is useful for confirmation of the diagnosis. Patients who present with metastatic DFSP-FS show less typical histologic findings and loss of CD34 staining, leaving PDGFB rearrangement as the preferred adjunctive method for diagnosis from small biopsies and for prediction  of the value of imatinib therapy.

 

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[59]

TÍTULO / TITLE:  - Kaposi’s Sarcoma-Associated Herpesvirus Oncoprotein K13 Protects against B Cell Receptor-Induced Growth Arrest and Apoptosis through NF-kappaB Activation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Feb;87(4):2242-52. doi: 10.1128/JVI.01393-12. Epub 2012 Dec 12.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.01393-12

AUTORES / AUTHORS:  - Graham C; Matta H; Yang Y; Yi H; Suo Y; Tolani B; Chaudhary PM

INSTITUCIÓN / INSTITUTION:  - Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein (vFLIP) K13 in the modulation of anti-IgM-induced growth arrest and apoptosis in B cells. We demonstrate that K13 protects WEHI 231, an immature B-cell line, against anti-IgM-induced growth arrest and apoptosis. The protective effect of K13 was associated with the activation of the NF-kappaB pathway and was deficient in a mutant K13 with three alanine substitutions at positions 58 to 60 (K13-58AAA) and a structural homolog, vFLIP E8, both of which  lack NF-kappaB activity. K13 upregulated the expression of NF-kappaB subunit RelB and blocked the anti-IgM-induced decline in c-Myc and rise in p27(Kip1) that have been associated with growth arrest and apoptosis. K13 also upregulated the expression of Mcl-1, an antiapoptotic member of the Bcl2 family. Finally, K13 protected the mature B-cell line Ramos against anti-IgM-induced apoptosis through NF-kappaB activation. Inhibition of anti-IgM-induced apoptosis by K13 may contribute to the development of KSHV-associated lymphoproliferative disorders.

 

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[60]

TÍTULO / TITLE:  - TGF-beta1 Signal is Crucial for De-Differentiation of Cancer Cells to Cancer Stem Cells in Osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Stem Cells. 2012 Dec 7. doi: 10.1002/stem.1298.

            ●● Enlace al texto completo (gratuito o de pago) 1002/stem.1298

AUTORES / AUTHORS:  - Zhang H; Wu H; Zheng J; Yu P; Xu L; Jiang P; Gao J; Wang H; Zhang Y

INSTITUCIÓN / INSTITUTION:  - Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, P. R. China.

RESUMEN / SUMMARY:  - Human osteosarcoma harbors a small subpopulation of cancer stem cells (CSCs) that is believed to be associated with tumor metastasis, radio/chemo-resistance, local invasion and poor clinical outcome. In this study, we found that TGF-beta1 signaling and a hypoxic environment dramatically induced self-renewal capacity in non-stem osteosarcoma cells, which in turn promoted chemo-resistance, tumorigenicity, neovasculogenesis and metastatic potential. Furthermore, blocking the TGF-beta1 signaling pathway resulted in the inhibition of the de-differentiation and clonogenicity of osteosarcoma cells, and the reduction of  CSC self-renewal capacity and hypoxia-mediated de-differentiation. These findings demonstrate that stem cells and non-stem cells exist in a dynamic equilibrium within the osteosarcoma cell population, and that CSCs may develop de novo from differentiated cancer cells. Hierarchical models of mammalian cancer stem cells,  therefore, should be considered to serve as bidirectional interconversion between the stem and non-stem cell components of the tumor.

 

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[61]

TÍTULO / TITLE:  - Congenital synmastia with concurrent fibroadenomas in a pediatric patient.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Surg. 2013 Jan;48(1):255-7. doi: 10.1016/j.jpedsurg.2012.10.053.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpedsurg.2012.10.053

AUTORES / AUTHORS:  - Fallon SC; Hatef DA; McKnight AJ; Izaddoost SA; Brandt ML

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX 77030, USA.

RESUMEN / SUMMARY:  - Congenital synmastia, or absence of the intermammary sulcus, is a rare breast anomaly in the pediatric population. While acquired synmastia after breast augmentation is a well-documented entity, congenital synmastia is a rare condition with only four previous cases reported in the surgical literature. We describe the first patient with concurrent presentation of congenital synmastia and multiple fibroadenomas. A combined technique was used to both address the patient’s breast lesions and correct the defect.

 

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[62]

TÍTULO / TITLE:  - Chondrosarcoma of the mandibular condyle in a patient with Werner syndrome: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniomaxillofac Surg. 2013 Jan 25. pii: S1010-5182(12)00301-0. doi: 10.1016/j.jcms.2012.11.045.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcms.2012.11.045

AUTORES / AUTHORS:  - Goutzanis L; Kalfarentzos EF; Petsinis V; Papadogeorgakis N

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery (Head: Professor Constantinos Alexandridis), “Evangelismos” General Hospital, University of Athens Dental School, 45-47 Ipsilantou Str, Athens, GR 10676, Greece.

RESUMEN / SUMMARY:  - Werner syndrome, also called progeria of the adult and pangeria is a rare autosomal recessive disorder that affects connective tissue throughout the body.  It is associated with premature ageing and an increased risk of cancer and other  diseases. The mean survival for patients with Werner syndrome is 47 years. Death  usually occurs when patients are aged 30-65 years because of atherosclerosis or malignant tumours. The purpose of this paper is to present a patient with Werner  syndrome exhibiting a chondrosarcoma of the left temporomandibular joint and ramus. To the best of our knowledge this is the first case, of a Werner syndrome  patient with an associated head and neck chondrosarcoma being reported. The diagnostic procedure followed and management of the patient are outlined in the paper as well.

 

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[63]

TÍTULO / TITLE:  - Phase II prospective study with sorafenib in advanced soft tissue sarcomas after  anthracycline-based therapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Oncol. 2012 Dec 9.

            ●● Enlace al texto completo (gratuito o de pago) 1093/annonc/mds607

AUTORES / AUTHORS:  - Santoro A; Comandone A; Basso U; Soto Parra H; De Sanctis R; Stroppa E; Marcon I; Giordano L; Lutman FR; Boglione A; Bertuzzi A

INSTITUCIÓN / INSTITUTION:  - Department of Oncology-Haematology, Humanitas Cancer Center, IRCCS, Milan.

RESUMEN / SUMMARY:  - IntroductionWe investigated the activity and safety of sorafenib, a multitargeted tyrosine-kinase inhibitor, in patients with advanced soft tissue sarcomas (STS).Patients and methodsAn open-label nonrandomised multicentre phase II study  was conducted in advanced STS patients pre-treated with anthracycline-based chemotherapy. Patients received sorafenib 400 mg twice daily for 28 days. The primary end point was the progression-free survival (PFS) rate at 6 months. Toxicity was assessed. Clinical outcomes were evaluated in all histologies and in leiomyosarcoma (L) and angiovascular sarcomas (A).ResultsBetween November 2006 and January 2010, 101 patients (36 L, 19 A, and 46 others) were enrolled; 76 patients per-protocol (PP) and 100 per intention-to-treat (ITT) were assessable for the primary end point. In the PP analysis, 11 (14.5%) achieved partial response and 25 (32.9%) stable disease; 6-month PFS rates were all histologies, 34.5%; L, 38.4%; and A, 56.3%. In the ITT analysis, 6-month PFS results were 27.1, 35, and 35.5% in all histologies, L, and A, respectively. When stratified by histology, we observed a better PFS favouring leiomyosarcoma versus other histologies (P = 0.033). Treatment was well tolerated.ConclusionsSorafenib appears to be a promising option in leiomyosarcoma patients. This finding warrants further evaluation in histology-driven trials.

 

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[64]

TÍTULO / TITLE:  - Expression and clinical relevance of MET and ALK in Ewing sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Cancer. 2013 Jan 21. doi: 10.1002/ijc.28047.

            ●● Enlace al texto completo (gratuito o de pago) 1002/ijc.28047

AUTORES / AUTHORS:  - Fleuren ED; Roeffen MH; Leenders WP; Flucke UE; Vlenterie M; Schreuder HW; Boerman OC; van der Graaf WT; Versleijen-Jonkers YM

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. E.Fleuren@onco.umcn.nl.

RESUMEN / SUMMARY:  - Because novel therapeutic options are limited in Ewing sarcomas (ES), we investigated the expression, genetic aberrations and clinical relevance of MET and Anaplastic Lymphoma Kinase (ALK) in ES and determined the relevance of targeting these receptors. MET and ALK protein expression was determined immunohistochemically in 31 (50 samples) and 36 (59 samples) ES patients, respectively. Samples included primary tumors, post-chemotherapy resections, metastases and relapses. MET and ALK RTK domains were sequenced in respectively 33 and 32 tumors. Five ES cell lines were treated in vitro with the MET/ALK-inhibitor crizotinib, the ALK-inhibitor NVP-TAE684 or the MET-inhibitor cabozantinib and analyzed by MTT-assays. Modest to high MET and ALK expression was detected in the majority of ES (86% and 69%, resp.). ALK expression was significantly lower in post-chemotherapy resections compared to paired untreated  primary tumors (p=0.031, z=-2.310, n=11). In primary tumors (n=20), membranous MET expression significantly correlated with a poor overall survival (OS) (60 vs. 197 months, p=0.014). There was a trend towards a poor event-free survival (EFS)  (67 vs. 111 months, p=0.078) and OS (88 vs. 128 months, p=0.074) in patients with highest ALK levels (n=29). ALK or MET RTK domain aberrations were demonstrated in 5/32 (16%) and 3/33 (9%) tumors, respectively. Crizotinib (IC(50) 1.22-3.59 mumol/L), NVP-TAE684 (IC(50) 0.15-0.79 mumol/L) and cabozantinib (IC(50) 2.69-8.27 mumol/L) affected ES cell viability in vitro. Altogether, our data suggest that MET and ALK are potential novel therapeutic targets in ES and targeting these receptors may be of great interest to rationally design future studies in ES.

 

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[65]

TÍTULO / TITLE:  - Synchronous Pure Epithelioid Angiomyolipoma of the Kidney and Retroperitoneal Schwannoma in the Same Patient on 18F-FDG PET/CT Imaging.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Feb;38(2):e98-e100. doi: 10.1097/RLU.0b013e31825b2218.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e31825b2218

AUTORES / AUTHORS:  - Dong A; Wang Y; Zuo C

INSTITUCIÓN / INSTITUTION:  - From the Departments of *Nuclear Medicine and daggerPathology, Changhai Hospital, Shanghai, China.

RESUMEN / SUMMARY:  - ABSTRACT: A 21-year-old woman was admitted to our hospital after incidental detection of a left renal lesion on ultrasound scan. Abdominal contrast-enhanced  CT scan revealed a moderately enhanced lesion in the left kidney and a round mass with slight enhancement in the retroperitoneum. FDG PET/CT imaging was performed  for whole-body survey, showing increased tracer accumulation in both the left renal and the retroperitoneal lesions. Left renal cell carcinoma with retroperitoneal metastasis was suspected. Synchronous pure epithelioid angiomyolipoma of the left kidney and retroperitoneal schwannoma were diagnosed by pathology. This case highlights that epithelioid angiomyolipoma should be considered as one of the differential diagnosis in renal lesions with increased FDG uptake.

 

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[66]

TÍTULO / TITLE:  - A Potent Combination of the Novel PI3K Inhibitor, GDC-0941, with Imatinib in Gastrointestinal Stromal Tumor Xenografts: Long-Lasting Responses after Treatment Withdrawal.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Cancer Res. 2013 Jan 15.

            ●● Enlace al texto completo (gratuito o de pago) 1158/1078-0432.CCR-12-2853

AUTORES / AUTHORS:  - Floris G; Wozniak A; Sciot R; Li H; Friedman L; Van Looy T; Wellens J; Vermaelen P; Deroose CM; Fletcher JA; Debiec-Rychter M; Schoffski P

INSTITUCIÓN / INSTITUTION:  - Authors’ Affiliations: Departments of Pathology, Nuclear Medicine and Molecular Imaging, and Human Genetics; Laboratory of Experimental Oncology, Department of Oncology and Department of General Medical Oncology, KU Leuven and University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium; Genentech, San Francisco, California; and Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts.

RESUMEN / SUMMARY:  - PURPOSE: Oncogenic signaling in gastrointestinal stromal tumors (GIST) is sustained via PI3K/AKT pathway. We used a panel of six GIST xenograft models to assess efficacy of GDC-0941 as single agent or in combination with imatinib (IMA).EXPERIMENTAL DESIGN: Nude mice (n = 136) were grafted bilaterally with human GIST carrying diverse KIT mutations. Mice were orally dosed over four weeks, grouped as follows: (A) control; (B) GDC-0941; (C) imatinib, and (D) GDC+IMA treatments. Xenografts regrowth after treatment discontinuation was assessed in groups C and D for an additional four weeks. Tumor response was assessed by volume measurements, micro-PET imaging, histopathology, and immunoblotting. Moreover, genomic alterations in PTEN/PI3K/AKT pathway were evaluated.RESULTS: In all models, GDC-0941 caused tumor growth stabilization, inhibiting tumor cell proliferation, but did not induce apoptosis. Under GDC+IMA, profound tumor regression, superior to either treatment alone, was observed. This effect was associated with the best histologic response, a nearly complete proliferation arrest and increased apoptosis. Tumor regrowth assays confirmed superior activity of GDC+IMA over imatinib; in three of six models, tumor volume  remained reduced and stable even after treatment discontinuation. A positive correlation between response to GDC+IMA and PTEN loss, both on gene and protein levels, was found.CONCLUSION: GDC+IMA has significant antitumor efficacy in GIST  xenografts, inducing more substantial tumor regression, apoptosis, and durable effects than imatinib. Notably, after treatment withdrawal, tumor regression was  sustained in tumors exposed to GDC+IMA, which was not observed under imatinib. Assessment of PTEN status may represent a useful predictive biomarker for patient selection. Clin Cancer Res; 1-11. (c)2012 AACR.

 

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[67]

TÍTULO / TITLE:  - Inhibition of the Wnt-beta-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochem Biophys Res Commun. 2013 Jan 3. pii: S0006-291X(12)02478-3. doi: 10.1016/j.bbrc.2012.12.118.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bbrc.2012.12.118

AUTORES / AUTHORS:  - Ma Y; Ren Y; Han EQ; Li H; Chen D; Jacobs JJ; Gitelis S; O’Keefe RJ; Konttinen YT; Yin G; Li TF

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, China.

RESUMEN / SUMMARY:  - Osteosarcoma (OS) is one of the most common malignant bone tumors in early adolescence. Multi-drug chemotherapy has greatly increased the five year survival rate from 20% to 70%. However, the rate has been staggering for 30years and the prognosis is particularly poor for patients with recurrence and metastasis. Our study aimed to investigate the role of Wnt-beta-catenin, Notch and Hedgehog pathway in OS development because all these pathways are involved in skeletal development, tumorigenesis and chemoresistance. Our results showed that the major components in Wnt-beta-catenin pathway, e.g. Wnt3a, beta-catenin and Lef1, were consistently upregulated in human osteosarcoma cell line Saos2 cells compared to  human fetal osteoblasts (hFOB), whereas the changes in the expression levels of Notch and Hh signaling molecules were not consistent. Knocking down beta-catenin  increased the Saos2 sensitivity to methotrexate (MTX) induced cell death. Consistently, the expression level of beta-catenin protein correlated with the invasiveness of OS, as evidenced by more intensive beta-catenin immunoreactivity  in higher grade OS samples. Chemical inhibition of the Wnt-beta-catenin signaling enhanced MTX mediated death of Saos2 cells. A synergistic effect with MTX was observed when both inhibitors for Wnt-beta-catenin and Notch pathways were simultaneously used, while the addition of the Hh inhibitor did not further improve the efficacy. Our findings provide some novel insight to OS pathogenesis  and lay a foundation for future application of Wnt-beta-catenin and Notch inhibitors together with the currently used chemotherapeutic drugs to improve the outcome of OS treatment.

 

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[68]

TÍTULO / TITLE:  - Embryonal Rhabdomyosarcoma (Botryoid Type) of the Uterine Corpus and Cervix in Adult Women: Report of a Case Series and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2013 Jan 22.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e31826e0271

AUTORES / AUTHORS:  - Li RF; Gupta M; McCluggage WG; Ronnett BM

INSTITUCIÓN / INSTITUTION:  - Departments of *Pathology double daggerGynecology & Obstetrics, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD daggerDepartment of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland.

RESUMEN / SUMMARY:  - In its classical form, embryonal rhabdomyosarcoma (ERMS, botryoid type) is a vaginal neoplasm occurring in infants and young girls and is often not considered in the differential diagnosis of uterine corpus and cervical spindle cell tumors  in adult women. Clinicopathologic and immunohistochemical features of 25 cases of ERMS in women 20 years of age or older were analyzed. Patient age ranged from 20  to 89 years (mean, 44.4 y; median, 46 y), with 8 patients aged 20 to 39 years, 14 patients aged 40 to 59 years, and 3 patients older than 60 years of age. Tumors originated in the cervix in 20 cases and in the uterine corpus in 5. They were characterized by an edematous hypocellular spindle cell proliferation, typically  with cellular condensation beneath epithelial surfaces (cambium layer), in which  tightly packed hypercellular foci were scattered. Neoplastic cells had hyperchromatic nuclei and minimal cytoplasm, usually with delicate cytoplasmic processes. Occasionally, elongated or globular cells with eosinophilic cytoplasm  (rhabdomyoblasts) were evident, but cytoplasmic cross-striations were only rarely identified. Apoptotic bodies and mitotic figures were usually identified in the hypercellular foci. Hemorrhage was common, often making recognition of the hypercellular foci difficult. Desmin and myogenin were coexpressed in 22 of 23 (95.6%) tumors evaluated. Proliferative activity, as assessed by Ki-67 expression, was notably elevated in all tumors evaluated, typically concentrated  in the hypercellular foci. Estrogen and progesterone receptors were expressed focally in only 3 of 12 (25%) and 1 of 8 (12.5%) tumors evaluated, respectively.  Follow-up was available in 7 cases. Five patients were alive without evidence of  disease with follow-up of 3 to 8 years, and 1 patient was alive with disease at 5 months. One patient died at 5 months with pulmonary nodules, but it was not determined whether this was due to metastatic ERMS or the patient’s known ductal  breast carcinoma. ERMS has a broader clinical profile than classically expected and should be considered in the differential diagnosis of a uterine corpus or cervical spindle cell tumor, regardless of patient age. Recognition can be rendered difficult by the hypocellular background, which can suggest a benign polyp or low-grade tumor, and hemorrhage, which can obscure the characteristic hypercellular foci. Identification of hypercellular foci in which mitotic activity and apoptotic bodies are found, desmin and myogenin are coexpressed, proliferative activity is notably elevated, and hormone receptor expression is usually absent is very useful for establishing the diagnosis.

 

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[69]

TÍTULO / TITLE:  - p63 regulates cell proliferation and cell cycle progressionassociated genes in stromal cells of giant cell tumor of the bone.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Oncol. 2013 Feb;42(2):437-43. doi: 10.3892/ijo.2012.1727. Epub 2012 Dec 3.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ijo.2012.1727

AUTORES / AUTHORS:  - Lau CP; Ng PK; Li MS; Tsui SK; Huang L; Kumta SM

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, SAR, P.R. China.

RESUMEN / SUMMARY:  - Giant cell tumor of bone (GCT) is a destructive neoplasm of uncertain etiology that affects the epiphyseal ends of long bones in young adults. GCT stromal cells (GCTSCs) are the primary neoplastic cells of this tumor and are the only proliferating cell component in long-term culture, which recruits osteoclast-like giant cells that eventually mediate bone destruction. The oncogenesis of GCT and  factors driving the neoplastic stromal cells to proliferate extensively and pause at an early differentiation stage of pre-osteoblast lineage remain unknown. Overexpression of p63 was observed in GCTSCs and there is growing evidence that p63 is involved in oncogenesis through different mechanisms. This study aimed to  understand the specific role of p63 in cell proliferation and oncogenesis of GCTSCs. We confirmed p63 expression in the mononuclear cells in GCT by immunohistochemical staining. By real-time PCR analysis, we showed a higher level (>15fold) of TAp63 expression in GCTSCs compared to that in mesenchymal stem cells. Furthermore, we observed that knockdown of the p63 gene by siRNA transfection greatly reduced cell proliferation and induced cell cycle arrest at  S phase in GCTSCs. We found that the mRNA expression of CDC2 and CDC25C was substantially suppressed by p63 knockdown at 24-72 h. Moreover, p63 was found to  be recruited on the regulatory regions of CDC2 and CDC25C, which contain p53-responsive elements. In summary, our data suggest that p63 regulates GCTSC proliferation by binding to the CDC2 and CDC25C p53-REs, which may inhibit the p53 tumor suppressor activity and contribute to GCT tumorigenesis.

 

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[70]

TÍTULO / TITLE:  - Conservative En Bloc Surgery for Aggressive Angiomyxoma Achieves Good Local Control: Analysis of 14 Patients From a Single Institution.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Gynecol Cancer. 2013 Jan 29.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IGC.0b013e3182843063

AUTORES / AUTHORS:  - Coppola S; Desai A; Tzanis D; Honore C; Bitsakou G; Pechoux CL; Terrier P; Bonvalot S

INSTITUCIÓN / INSTITUTION:  - From the *Department of Surgery, Institut Gustave Roussy, Villejuif, France; daggerDepartment of Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom; and Departments of double daggerRadiotherapy and section signPathology,  Institut Gustave Roussy, Villejuif, France.

RESUMEN / SUMMARY:  - BACKGROUND: The purpose of this study was to assess the value of conservative surgery in aggressive angiomyxoma (AA) in our institutional series. METHOD: This  was a retrospective review of patients with AA treated at our institution between 1999 and 2010. RESULTS: Fourteen consecutive patients were analyzed: 8 primary tumors and 6 recurrences. Female/male ratio was 13:1; median female age was 36 years. Median size of primary lesions was 12 cm (range, 7-17 cm). Median size of  recurrences was 20.5 cm (range, 3-44 cm). Twelve patients were operated on. Two asymptomatic patients whose surgery would have been mutilating were placed under  wait and see. Four patients had concomitant visceral resections because of massive infiltration. No tumor rupture was recorded on pathological examination.  Margins were R0 (n = 2), R1 (n = 10), and R2 (n = 0). Seven patients (50%) received radiotherapy. Median postoperative follow-up was 69 months, and no patient was lost at follow-up. All patients operated on (primaries and recurrences) had no evidence of recurrence. CONCLUSION: Conservative and planned  en bloc surgery achieves good local control with low morbidity. Radiotherapy could enhance local control in advanced disease. Wait and see is an exploratory option for asymptomatic, stable, and nonprogressing AA in which surgery would be  mutilating.

 

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[71]

TÍTULO / TITLE:  - Aortic valve papillary fibroelastoma associated with severe aortic regurgitation: a comprehensive assessment with 2- and 3-dimensional transesophageal echocardiography.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Am Coll Cardiol. 2012 Dec 11;60(23):e41. doi: 10.1016/j.jacc.2012.06.061.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jacc.2012.06.061

AUTORES / AUTHORS:  - Buppajarntham S; Satitthummanid S; Chantranuwatana P; Luengtaviboon K; Chattranukulchai P; Boonyaratavej S; Puwanant S

INSTITUCIÓN / INSTITUTION:  - Division of Cardiology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

 

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[72]

TÍTULO / TITLE:  - Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of  bone marrow mesenchymal stem cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bone. 2013 Jan 17. pii: S8756-3282(13)00017-3. doi: 10.1016/j.bone.2012.12.052.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bone.2012.12.052

AUTORES / AUTHORS:  - Wan Y; Lu C; Cao J; Zhou R; Yao Y; Yu J; Zhang L; Zhao H; Li H; Zhao J; Zhu X; He L; Liu Y; Yao Z; Yang X; Guo X

INSTITUCIÓN / INSTITUTION:  - Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, 200240, China.

RESUMEN / SUMMARY:  - Wnt signaling has important roles in embryonic bone development and postnatal bone remodeling, but inconsistent impact on bone property is observed in different genetic alterations of Lrp5 and beta-catenin. More importantly, it is still controversial whether Lrp5 regulate bone formation locally or globally through gut-derived serotonin. Here we explored the function of Wnt proteins in osteoblastic niche through inactivation of the Wntless (Wls) gene, which abrogates the secretion of Wnts. The depletion of Wls in osteoblast progenitor cells resulted in severe osteopenia with more profound defects in osteoblastogenesis, osteoclastogenesis and maintenance of bone marrow mesenchymal stem cells (BMSCs) compared to that observed in Lrp5 and beta-catenin mutants. These findings support the point of view that Wnt/Lrp5 signaling locally regulates bone mass accrual through multiple effects of osteoblastic Wnts on osteoblastic bone formation and osteoclastic bone resorption. Moreover, osteoblastic Wnts confer a niche role for maintenance of BMSCs, providing novel cues for the definition of BMSCs niche in bone marrow.

 

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[73]

TÍTULO / TITLE:  - Reduced mitochondrial DNA copy number in peripheral blood leukocytes increases the risk of soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Carcinogenesis. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1093/carcin/bgt023

AUTORES / AUTHORS:  - Xie H; Lev D; Gong Y; Wang S; Pollock RE; Wu X; Gu J

INSTITUCIÓN / INSTITUTION:  - Department of Epidemiology, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, China.

RESUMEN / SUMMARY:  - BACKGROUND: Mitochondrial DNA (mtDNA) has increased susceptibility to damage due  to its close proximity to the site of reactive oxygen species production, lack of introns and protective histones, and less efficient DNA repair mechanisms than nuclear DNA. The relationship between mtDNA copy number in peripheral blood leukocytes (PBLs) and the risk of soft tissue sarcoma (STS) has not been investigated.METHODS: We determined the relative mtDNA copy number in PBLs in this case-control study. Study participants included 325 patients with histologically confirmed STS (cases) and 330 healthy controls that were frequency-matched to cases according to age, sex, and ethnicity. RESULTS: Cases had a significantly lower mtDNA copy number than controls (0.93 +/- 0.49 for cases vs. 1.23 +/- 0.59 for controls; P < 0.001). In analyses stratified by sex,  ethnicity and smoking status, mtDNA copy number was lower in the cases than in controls in any stratum. Using the median mtDNA copy number in controls as a cutoff, individuals with lower mtDNA copy number were associated with a significantly increased risk of STS compared to those with higher mtDNA copy number (adjusted odds ratio, 2.71; 95% confidence interval, 1.94-3.82). There was a significant dose-response relationship between reduced mtDNA copy number and increased risk of STS in tertile and quartile analyses.CONCLUSIONS: The present study provides the first epidemiologic evidence that reduced mtDNA copy number in PBLs is significantly associated with an increased risk of STS, thereby suggesting an important role of mtDNA in STS development.

 

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[74]

TÍTULO / TITLE:  - Intronic deletion and duplication proximal of the EXT1 gene: A novel causative mechanism for multiple osteochondromas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genes Chromosomes Cancer. 2013 Jan 23. doi: 10.1002/gcc.22041.

            ●● Enlace al texto completo (gratuito o de pago) 1002/gcc.22041

AUTORES / AUTHORS:  - Waaijer CJ; Winter MG; Reijnders CM; de Jong D; John Ham S; Bovee JV; Szuhai K

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.

RESUMEN / SUMMARY:  - Multiple osteochondromas (MO) is a syndrome in which benign cartilage-capped neoplasms develop at the surface of the long bones. Most cases are caused by exonic changes in EXT1 or EXT2, but 15% are negative for these changes. Here we report for the first time a family of MO patients with germline genomic alterations at the EXT1 locus without detectable mutations or copy number alterations of EXT exonic sequences. Array-CGH showed an 80.7 kb deletion of Intron 1 of EXT1 and a 68.9 kb duplication proximal of EXT1. We identified a breakpoint between the distal end of the duplicated region and a sequence distal  of the deleted region in the first intron. This breakpoint was absent in non-affected family members. The configuration of the breakpoint indicates a direct insertion of the duplicated region into the deletion. However, no other breakpoint was found, which suggests a more complex genomic rearrangement has occurred within the duplicated region. Our results reveal intronic deletion and duplication as a new causative mechanism for MO not detected by conventional diagnostic methods. © 2013 Wiley Periodicals, Inc.

 

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[75]

TÍTULO / TITLE:  - Inflammatory Myofibroblastic Tumors Following the Treatment of Malignancy in Childhood: Case Reports.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Hematol Oncol. 2012 Dec 28.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MPH.0b013e31827e5302

AUTORES / AUTHORS:  - Adamski; Kelsey A; Brennan B

INSTITUCIÓN / INSTITUTION:  - Royal Manchester Children’s Hospital, Manchester, UK.

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumors (IMT) are rare, mostly benign soft tissue tumors. Occurring mainly in children the presentation, clinical features, and diagnostic dilemmas raised are well reported. Here we describe 4 patients diagnosed with IMT after the treatment of childhood cancer, and review the literature regarding IMT and malignancy. Discussing them in this context raises clinical questions; Are these tumors incidental or a consequence of treatment? Are they more common than we think and are any miss-diagnosed as tumor recurrence? This paper aims to raise awareness of IMT as diagnostic possibilities after treatment for childhood malignancies.

 

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[76]

TÍTULO / TITLE:  - Hepatic Hemangiosarcoma: An Absolute Contraindication to Liver Transplantation-The European Liver Transplant Registry Experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Transplantation. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1097/TP.0b013e318281b902

AUTORES / AUTHORS:  - Orlando G; Adam R; Mirza D; Soderdahl G; Porte RJ; Paul A; Burroughs AK; Seiler CA; Colledan M; Graziadei I; Garcia Valdecasas JC; Pruvot FR; Karam V; Lerut J

INSTITUCIÓN / INSTITUTION:  - 1 Starzl Abdominal Transplant Unit, University Hospitals St. Luc, Brussels, Belgium. 2 Centre Hepatobiliaire Paul Brousse, Paris, France. 3 Liver Unit, Queen Elizabeth Hospital, Birmingham, UK. 4 Department of Transplantation, Karolinska University Hospital, Huddinge, Stockholm, Sweden. 5 Department of Hepatobiliary Surgery and Liver Transplantation, UMC Groningen, the Netherlands. 6 Department of General and Transplantation Surgery, University Hospital of Essen, Essen, Germany. 7The Royal Free Sheimla Sherlock Liver Centre and University Department  of Surgery, Royal Free Hospital and UCL, London, UK. 8 Department of Visceral and Transplantation Surgery, Inselspital, Bern, Switzerland. 9 Department of Lung and Liver Transplantation, Ospedali Riuniti, Bergamo, Italy. 10 Universitatsklinik, Innsbruck, Austria. 11 Department of Hepatobiliary and Liver Transplantation Surgery, Hospital Clinic I Provincial, Barcelona, España. 12 Service Chirurgie Digestive et Transplantations, CHU, Univ Nord-de-France, Lille, France. 13 ELT Registry, Paris, France. 14 Currently, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC. 15 Address correspondence to: Prof. Jan Lerut, M.D., Ph.D., F.A.C.S., Starzl Abdominal Transplant Unit, University Hospitals St. Luc, Department of Abdominal Surgery and Transplantation, Universite catholique de Louvain (UCL), Avenue Hippocrate 10, 1200 Brussels, Belgium.

RESUMEN / SUMMARY:  - BACKGROUND: Liver transplantation (LT) is performed for hemangiosarcoma (HAS) despite disappointing results. METHODS: Retrospective study of 14 males and 8 females reported to the European Liver Transplant Registry. In view of the difficult differential diagnosis between HAS and hemangioendothelioma (HE), the study was deliberately restricted to the period 1986 to 2004 to allow comparison  of clinical and biochemical behavior of HAS and HE liver recipients transplanted  during the same time period. RESULTS: Clinical signs, symptoms, and biochemical parameters differed significantly. Pre-LT diagnosis of HAS was made in only 5 of  16 (31%) biopsied patients. HE (7 patients) and hepatocellular cancer (2 patients) were confounding diagnoses leading to LT. Extrahepatic disease was present at time of LT in 4 (19%) patients. Giant invalidating tumor (5 HAS, 1 with Budd-Chiari syndrome [BCS], and 10 supposed epithelioid hemangioendothelioma, 1 with BCS), acute BCS of unknown origin (2 patients), chronic liver failure (4 patients), and solitary hepatocellular cancer (1 patient) were the main indications for LT. Overall survival was 7.2+/-2.6 months; no patient survived after 23 months. Recurrence was diagnosed after 5.0+/-2.6 months. Seventeen (77.2%) patients died of tumor recurrence, and the remaining 5  patients died of early infections. CONCLUSIONS: HAS is an absolute contraindication to LT due to the poor outcome. When dealing with the difficult differential diagnosis between HAS and HE, futile LT can be avoided by taking into consideration their distinct clinical and biochemical behaviors as well as a 6-month wait-list observation period. This time period enables the evaluation of  HAS disease progression without compromising prognosis of HE patients, thereby allowing to avoid organ wastage.

 

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[77]

TÍTULO / TITLE:  - Long-term follow-up outcome of imatinib mesylate treatment for recurrent and unresectable gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Digestion. 2013;87(1):47-52. doi: 10.1159/000343938. Epub 2013 Jan 21.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000343938

AUTORES / AUTHORS:  - Saito S; Nakata K; Kajiura S; Ando T; Hosokawa A; Sugiyama T

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

RESUMEN / SUMMARY:  - Background: The follow-up study of up to 71 months of a randomized phase II B2222 trial has demonstrated a long-term survival in patients with recurrent or unresectable gastrointestinal stromal tumors (GISTs). One subset of the patients  (17.7%) has been alive for over 9 years with continuous imatinib mesylate (imatinib) treatment. Here, we report the retrospective analysis of recurrent or  unresectable GIST patients with imatinib treatment at our institution. Methods: We summarized the data of 20 patients with recurrent or unresectable GIST treated with imatinib. Results: Patients were followed for a median of 40 months (range 2.5-103) under imatinib treatment. The median progression-free survival (PFS) was 89 months and overall survival for 8 years was 67%. Fifteen patients showed continuous partial response or stable disease with imatinib treatment. The median PFS was 45 months and the median size of the primary tumor was 7.6 cm (range 2.8-18). Four patients showed progressive disease. The median PFS was 56 months and the median size of the primary tumor was 11.9 cm (range 6.7-19). Grade 3 or 4 adverse events occurred in neutropenia (10%), anemia (15%) and renal dysfunction  (5%). However, all patients were well managed by supportive treatment and none were discontinued from imatinib treatment due to toxicity or adverse events. Conclusion: Imatinib had a high efficacy in patients with unresectable and recurrent GIST during long-term follow-up. All patients were well managed by supportive treatment against adverse events and they were able to take imatinib without discontinuation. The management of adverse events was a key factor for achieving a long-term survival. In addition, the potential risk of imatinib-resistant GISTs tends to depend on the size of the primary GISTs.

 

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[78]

TÍTULO / TITLE:  - Zoledronic acid significantly enhances radiationinduced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Oncol. 2013 Feb;42(2):525-34. doi: 10.3892/ijo.2012.1735. Epub 2012 Dec 12.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ijo.2012.1735

AUTORES / AUTHORS:  - Koto K; Murata H; Kimura S; Sawai Y; Horie N; Matsui T; Ryu K; Ashihara E; Maekawa T; Kubo T; Fushiki S

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.

RESUMEN / SUMMARY:  - Zoledronic acid (ZOL), a third-generation bisphosphonate, inhibits bone resorption, as well as exhibiting direct antitumor activity. To date, however, the combined effects of ZOL and ionizing radiation (IR) have not been assessed in patients with soft tissue sarcoma. We have, therefore, assessed the combined effects of ZOL and IR in fibrosarcoma cells. HT1080 fibrosarcoma cells were treated with ZOL and/or IR, together or sequentially and the antitumor effects were assessed. We found that ZOL significantly enhanced IR-induced apoptosis, especially when cells were treated with ZOL followed by IR. We, therefore, assessed the detailed mechanism of sequential treatment with ZOL and IR. Cells in G2 and M phases, the most radiosensitive phases of the cell cycle, were not increased by low concentrations of ZOL. However, the levels of expression of Akt, ERK1/2 and NF-kappaB proteins, all of which are related to radioadaptive resistance, were increased within a short time after irradiation with 3 Gy, and this expression was inhibited by a low concentration of ZOL, which blocked the prenylation of small GTPases. This sequential treatment also increased the generation of reactive oxygen species (ROS). These results suggest that the combination of ZOL with IR may be beneficial in treating patients with soft tissue sarcoma.

 

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[79]

TÍTULO / TITLE:  - Increased FDG Activity in a Dermatofibroma in Esophageal Cancer Patient.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e318263869d

AUTORES / AUTHORS:  - Bingham BA; Hatef DA; Chevez-Barrios P; Blackmon SH; Kim MP

INSTITUCIÓN / INSTITUTION:  - From the *Department of Surgery, The Methodist Hospital; daggerDepartment of Plastic Surgery, Baylor College of Medicine; and double daggerDepartment of Pathology, The Methodist Hospital, Houston, TX.

RESUMEN / SUMMARY:  - ABSTRACT: PET using the radiotracer F-FDG is used for staging patients with esophageal cancer. Nonmalignant conditions, mainly inflammation and some benign tumors, however, can cloud the clinical picture by taking up FDG and producing a  false-positive result. We report the case of a 46 year-old man with squamous cell carcinoma of the thoracic esophagus who underwent combined PET/CT and had false-positive uptake in a chest wall dermatofibroma. Dermatofibroma is a benign  skin lesion with a characteristic large presence of fibroblasts and macrophages.  Macrophage uptake of FDG is likely responsible for the false-positive result on PET/CT.

 

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[80]

TÍTULO / TITLE:  - Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mod Pathol. 2012 Nov 30. doi: 10.1038/modpathol.2012.199.

            ●● Enlace al texto completo (gratuito o de pago) 1038/modpathol.2012.199

AUTORES / AUTHORS:  - Ryan RJ; Akin C; Castells M; Wills M; Selig MK; Nielsen GP; Ferry JA; Hornick JL

INSTITUCIÓN / INSTITUTION:  - Pathology Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.

RESUMEN / SUMMARY:  - Mast cell sarcoma is a rare, aggressive neoplasm composed of cytologically malignant mast cells presenting as a solitary mass. Previous descriptions of mast cell sarcoma have been limited to single case reports, and the pathologic features of this entity are not well known. Here, we report three new cases of mast cell sarcoma and review previously reported cases. Mast cell sarcoma has a characteristic morphology of medium-sized to large epithelioid cells, including bizarre multinucleated cells, and does not closely resemble either normal mast cells or the spindle cells of systemic mastocytosis. One of our three cases arose in a patient with a remote history of infantile cutaneous mastocytosis, an association also noted in one previous case report. None of our three cases were  correctly diagnosed as mast cell neoplasms on initial pathological evaluation, suggesting that this entity may be under-recognized. Molecular testing of mast cell sarcoma has not thus far detected the imatinib-resistant KIT D816V mutation, suggesting that recognition of these cases may facilitate specific targeted therapy.Modern Pathology advance online publication, 30 November 2012; doi:10.1038/modpathol.2012.199.

 

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[81]

TÍTULO / TITLE:  - Two patients with primary sellar leiomyomas, a rare entity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Neurosci. 2012 Dec 6. pii: S0967-5868(12)00347-5. doi: 10.1016/j.jocn.2012.07.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jocn.2012.07.001

AUTORES / AUTHORS:  - Ko A; Su DK; Born D; Desantis A; Alan Failor R; Ferreira M Jr

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, University of Washington School of Medicine, 1959 NE  Pacific Way, Seattle, WA 98195, USA.

RESUMEN / SUMMARY:  - Leiomyomas are benign smooth muscle tumors commonly found in the genitourinary or gastrointestinal tracts. Rarely, they present as primary intracranial extra-axial brain tumors. Most of these lesions have been described in immunocompromised patients, but have been found very rarely in the immunocompetent patient. We present two patients with sporadic sellar leiomyomas. The first patient is a 25-year-old woman who presented with a 2-year history of amenorrhea and a heterogeneous lesion. The second is a 53-year-old man who presented with headaches and progressive panhypopituitarism, and a large cystic lesion expanding the sella. In both patients, transnasal transphenoidal surgery was performed for  resection of the tumor. We review the intraoperative findings, neuropathology and immunohistochemistry and the clinical follow-up. A literature search, which revealed only two prior reported cases of sporadic sellar leiomyomas, and subsequent review led us to conclude that the natural history of sellar leiomyomas relates to the immune status of the patient and that these tumors may  cause pituitary dysfunction through infiltration of the gland, mass effect and compression, or even potentially as a byproduct of prolactin secretion intrinsic  to the tumor itself. Complete surgical resection of these infiltrating tumors may not be advisable when pituitary function is intact. Long-term endocrine follow-up in these patients is advised.

 

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[82]

TÍTULO / TITLE:  - Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target  in soft tissue neoplasms with myoid differentiation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Jan 15. pii: S0046-8177(12)00365-6. doi: 10.1016/j.humpath.2012.10.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.10.001

AUTORES / AUTHORS:  - Dickson BC; Riddle ND; Brooks JS; Pasha TL; Zhang PJ

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, University of Toronto, Ontario, Canada M5S 1A8.

RESUMEN / SUMMARY:  - Sirtuin, silent mating-type information regulation 2 homolog Saccharomyces cerevisiae 1 (SIRT1), is a protein that has been implicated in multiple mammalian functions including cell aging, stress resistance, and differentiation. SIRT1 has also been shown to be involved in multiple tumors. In addition, new pharmacotherapies have recently been approved that target SIRT1. The purpose of this study was to use immunohistochemistry to characterize SIRT1 protein expression in human soft tissue neoplasms with the hopes of finding new diagnostic and therapeutic modalities. SIRT1 immunoreactivity was reviewed in a series of 164 soft tissue tumors including alveolar soft part sarcoma, angiomyolipoma, clear cell sarcoma, desmoid/fibromatosis, desmoplastic small round cell tumor, Ewing sarcoma, gastrointestinal stromal tumor, glomus tumor, leiomyoma, leiomyosarcoma, lipoma, liposarcoma, malignant peripheral nerve sheath tumor, nodular fasciitis, osteosarcoma, rhabdomyosarcoma, schwannoma, solitary fibrous tumor, synovial sarcoma, undifferentiated pleomorphic sarcoma, and Wilms  tumor. In addition, numerous benign tissues were tested for SIRT1 reactivity. In  nonneoplastic tissue, strong cytoplasmic SIRT1 reactivity was observed in all prostate stroma, smooth muscle, and striated muscle. A similar pattern of cytoplasmic SIRT1 expression was observed in soft tissue neoplasms with myoid differentiation, namely, angiomyolipoma (100%), glomus tumor (100%), leiomyoma (90%), leiomyosarcoma (76.5%), and rhabdomyosarcoma (87%). The other lesions examined were negative. Although the physiologic role of SIRT1 remains to be clarified in myoid tissues and neoplasms differentiating along these lines, this  observation points to a potential role for this marker in diagnostic immunohistochemistry. Furthermore, the recent emergence of drugs capable of selectively inhibiting SIRT1 raises the possibility of a potential application for targeted therapy. Additional studies are necessary to further characterise the role of SIRT1 in myoid tissues and neoplasms.

 

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[83]

TÍTULO / TITLE:  - Gene expression analysis reveals an angiogenic profile in uterine leiomyoma pseudocapsule.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Hum Reprod. 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1093/molehr/gat007

AUTORES / AUTHORS:  - Di Tommaso S; Massari S; Malvasi A; Bozzetti MP; Tinelli A

INSTITUCIÓN / INSTITUTION:  - Department of Biological and Environmental Sciences and Technologies, University  of Salento, 73100 Lecce, Italy.

RESUMEN / SUMMARY:  - The pseudocapsule (PC) of the uterine leiomyoma (UL) is an anatomic entity that surrounds the myoma separating it from the myometrium (UM). Although a number of  microarray experiments have identified differences in gene expression profile in  the UL when compared with the UM, there is a lack of systematic studies on the PC. In this study, quantitative RT-PCR (qRT-PCR) analysis was performed on 18 matched PC, UL and UM specimens and results showed that the PC displays a specific gene expression profile. The low expression levels of insulin-like growth factor (IGF-2), a fibroid specific marker, that we found in the PC and the UM when compared with the UL, clearly indicates that the PC is in structural continuity with the UM. However, the significant increase of endoglin expression  level in PC with respect to the UL and UM indicate that an active neo-angiogenesis is present in PC. Conversely, other angiogenic factors such as von Willebrand factor (vWF) and vascular endothelial growth factor A (VEGF-A) seem to have little influence on the PC angiogenesis. Since the endoglin is preferentially expressed in proliferating endothelial cells, while the vWF and VEGF-A are preferentially expressed in pre-existing endothelial cells, our idea is that the angiogenic activity in the PC is linked to wound healing. The angiogenic activity is also sustained by intermediate expression level of cystein-rich angiogenesis inducer 61 (CYR61), connective tissue growth factor (CTGF), and collagen 4alpha2 (COL4A2) genes all involved in the neo-angiogenesis, that we detected in the PC. Taken together our data demonstrate that the specific expression pattern observed in the PC could be the response of the uterine wall’s smooth cells to the tension imposed by the tumor. As a consequence, a neo-vascular structure is generated involving regenerative processes. For these reasons we suggest that the intracapsular laparoscopic myomectomy (LIM), a new surgical technique that preserves the PC during the UL removal, should always be  preferred, in order to favor a faster and proper uterine healing.

 

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[84]

TÍTULO / TITLE:  - Activator Protein-1 Inhibition by 3-[(Dodecylthiocarbonyl)Methyl]-Glutamaride Impairs Invasion and Radiosensitizes Osteosarcoma Cells In Vitro.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Biother Radiopharm. 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1089/cbr.2012.1305

AUTORES / AUTHORS:  - Brassesco MS; Pezuk JA; de Oliveira JC; Valera ET; de Oliveira HF; Scrideli CA; Umezawa K; Tone LG

INSTITUCIÓN / INSTITUTION:  - 1 Division of Pediatric Oncology, Department of Pediatrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo , Ribeirao Preto, Brazil .

RESUMEN / SUMMARY:  - Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor. Despite advances in neoadjuvant multi-agent chemotherapy, the outcome of patients has not significantly improved in the last decades, making the search for more effective therapeutic agents imperative. In the present study, we explored the possibility of using activator protein-1 inhibition by 3-[(dodecylthiocarbonyl)methyl]-glutarimide (DTCM-g) as a new therapeutic strategy in two OS cell lines, HOS and MG-63. Our results showed that low concentrations (2.5, 5, 10, and 20 mug/mL) of the drug significantly decreased cell proliferation and clonogenic capacity, albeit it did not significantly induce cell death. DTCM-g also decreased cell invasiveness, and inhibited PDPN, MMP-2, TIMP1, and TIMP2 expressions. Moreover, our results showed that DTCM-g synergized with ionizing radiation in both cell lines while chemosensitized MG-63 cells to doxorubicin treatment. Even though additional laboratorial and preclinical tests are still needed to support our data, we demonstrate that DTCM-g inhibits growth in OS cells, increases the cytotoxicity of other commonly  used agents, and may possess antimetastatic activity.

 

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[85]

TÍTULO / TITLE:  - A Virally Encoded Small Peptide Regulates RTA Stability and Facilitates Kaposi’s  Sarcoma-associated Herpesvirus Lytic Replication.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Virol. 2013 Jan 9.

            ●● Enlace al texto completo (gratuito o de pago) 1128/JVI.02746-12

AUTORES / AUTHORS:  - Jaber T; Yuan Y

INSTITUCIÓN / INSTITUTION:  - Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania USA.

RESUMEN / SUMMARY:  - In both mammalian and viral genomes, a large proportion of sequences are transcribed and annotated as noncoding RNAs. A polyadenylated RNA of 3.0 kb (T3.0) is transcribed from the opposite strand of ORF50 DNA template in the KSHV  genome and has been previously annotated as a non-coding RNA. ORF50 encodes the replication and transcription activator (RTA) that controls switch of the virus between latent and lytic life cycle. Here we show that T3.0 encodes a small peptide of 48 amino acids (designated viral Small Peptide-1 or vSP-1). vSP-1 interacts with RTA at the protein abundance regulatory motifs (PARS) and the association prevents RTA from being subjected to degradation through the ubiquitin-proteasome pathway. As a consequence, vSP-1 facilitates KSHV gene expression and lytic replication. This finding revealed a novel mechanism of gene regulation in viral life cycle.

 

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[86]

TÍTULO / TITLE:  - Epigenetic diversity of Kaposi’s sarcoma-associated herpesvirus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nucleic Acids Res. 2013 Jan 29.

            ●● Enlace al texto completo (gratuito o de pago) 1093/nar/gkt033

AUTORES / AUTHORS:  - Darst RP; Haecker I; Pardo CE; Renne R; Kladde MP

INSTITUCIÓN / INSTITUTION:  - Department of Biochemistry and Molecular Biology, 2033 Mowry Road, Box 103633, University of Florida College of Medicine, Gainesville, FL, 32610, USA, University of Florida Shands Cancer Center Program in Cancer Genetics, Epigenetics and Tumor Virology, University of Florida College of Medicine, Gainesville, FL, 32610, USA and Department of Molecular Genetics and Microbiology, 2033 Mowry Road, Box 103633, University of Florida College of Medicine, Gainesville, FL, 32610, USA.

RESUMEN / SUMMARY:  - Spontaneous lytic reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV)  occurs at a low rate in latently infected cells in disease and culture. This suggests imperfect epigenetic maintenance of viral transcription programs, perhaps due to variability in chromatin structure at specific loci across the population of KSHV episomal genomes. To characterize this locus-specific chromatin structural diversity, we used MAPit single-molecule footprinting, which simultaneously maps endogenous CG methylation and accessibility to M.CviPI at GC  sites. Diverse chromatin structures were detected at the LANA, RTA and vIL6 promoters. At each locus, chromatin ranged from fully closed to fully open across the population. This diversity has not previously been reported in a virus. Phorbol ester and RTA transgene induction were used to identify chromatin conformations associated with reactivation of lytic transcription, which only a fraction of episomes had. Moreover, certain chromatin conformations correlated with CG methylation patterns at the RTA and vIL6 promoters. This indicated that some of the diverse chromatin conformations at these loci were epigenetically distinct. Finally, by comparing chromatin structures from a cell line infected with constitutively latent virus, we identified products of lytic replication. Our findings show that epigenetic drift can restrict viral propagation by chromatin compaction at latent and lytic promoters.

 

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[87]

TÍTULO / TITLE:  - Killing two birds with one stone: BRAF V600E inhibitor therapy for hairy cell leukemia and Langerhans/dendritic cell sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Hematol. 2013 Jan 16.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00277-013-1681-9

AUTORES / AUTHORS:  - Subbiah V; Subbiah IM

INSTITUCIÓN / INSTITUTION:  - Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Unit 455, 1515 Holcombe Boulevard, Houston, TX, 77030-4009, USA, vsubbiah@mdanderson.org.

 

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[88]

TÍTULO / TITLE:  - Micro-metastases into the uterine leiomyoma from invasive ductal breast cancer under adjuvant tamoxifen therapy: case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Gynaecol Oncol. 2012;33(6):652-5.

AUTORES / AUTHORS:  - Dirican A; Kucukzeybek Y; Somali I; Erten C; Demir L; Can A; Bayoglu IV; Yigit SC; Unay FC; Yetimalar MH; Tarhan MO

INSTITUCIÓN / INSTITUTION:  - Medical Oncology Clinic, Izmir Ataturk Training and Research Hospital, Izmir, Turkey.

RESUMEN / SUMMARY:  - Metastasis of breast cancer to the uterus is extremely rare. However, breast cancer is the leading tumor metastasizing from extragenital organs to the uterus. The most common signs of uterine metastasis are bleeding and mass effect. Tamoxifen use is known to increase risk of endometrial cancer. Immunohistochemical staining with GCDFP can be useful in differentiating primary  uterine tumors from breast cancer metastasis. Metastasis to the uterus has been reported to worsen the prognosis. Although hysterectomy has been effective on survival, treatment modality to be used in the presence of other systemic metastases is not clear. Locoregional treatments can be used in oligometastatic cases. In addition, removal of solitary organ metastasis together with bone metastasis provides improvement in survival.

 

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[89]

TÍTULO / TITLE:  - Xiao Jin Wan, a traditional Chinese herbal formula, inhibits proliferation via arresting cell cycle progression at the G2/M phase and promoting apoptosis via activating the mitochondrialdependent pathway in U-2OS human osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Oncol. 2013 Mar;42(3):1070-80. doi: 10.3892/ijo.2013.1795. Epub 2013 Jan 23.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ijo.2013.1795

AUTORES / AUTHORS:  - Wu G; Chu J; Huang Z; Ye J; Chen P; Zheng C; Li X; Liu X; Wu M

INSTITUCIÓN / INSTITUTION:  - Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, P.R. China.

RESUMEN / SUMMARY:  - Xiao Jin Wan (XJW) is a well-known traditional Chinese folk-medicine, which is commonly used for the treatment of various types of diseases including cancers. However, the mechanism of the anticancer activity of XJW against U-2OS human osteosarcoma cells, have not yet been reported. In the present study, we investigated the cellular effects of the XJW on the U-2OS human osteosarcoma cell line. Our results showed that XJW induced cell morphological changes, reduced cell viability in a dose- and time-dependent manner and arrested in the G2/M phase of the cell cycle suggesting that XJW inhibited the proliferation of U-2OS  cells. Hoechst 33258 staining and Annexin V/propidium iodide double staining exhibited the typical nuclear features of apoptosis and increased the proportion  of apoptotic Annexin V-positive cells in a dose-dependent manner, respectively. In addition, XJW treatment caused loss of plasma membrane asymmetry, collapse of  mitochondrial membrane potential, activation of caspase-9 and caspase-3, and increase of the ratio of pro-apoptotic Bax to anti-apoptotic Bcl-2. Taken together, the results indicate that the U-2OS cell growth inhibitory activity of  XJW was due to cell cycle arrested and mitochondrial-mediated apoptosis, which may partly explain the anticancer activity of Xiao Jin Wan.

 

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[90]

TÍTULO / TITLE:  - Interleukin-6 induces vascular endothelial growth factor expression and promotes  angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochem Pharmacol. 2013 Feb 15;85(4):531-40. doi: 10.1016/j.bcp.2012.11.021. Epub 2012 Dec 5.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bcp.2012.11.021

AUTORES / AUTHORS:  - Tzeng HE; Tsai CH; Chang ZL; Su CM; Wang SW; Hwang WL; Tang CH

INSTITUCIÓN / INSTITUTION:  - Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, ROC; Division of Hematology/Oncology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.

RESUMEN / SUMMARY:  - Osteosarcoma is characterized by a high malignant and metastatic potential. Angiogenesis is essential for the caner metastasis. Interleukin-6 (IL-6) is a multifunctional cytokine that is associated with the disease status and outcomes  of cancers. However, the relationship between IL-6 and vascular endothelial growth factor (VEGF) expression in human osteosarcoma is mostly unknown. Here we  found that the IL-6 and VEGF expression was correlated with tumor stage and significantly higher than that in normal bone. Incubation of osteosarcoma cells with IL-6 increased VEGF mRNA and protein expression. Pretreatment of cells with  IL-6R antibody reduced IL-6-mediated VEGF production. The apoptosis signal-regulating kinase 1 (ASK1)/p38/AP-1 pathway was activated after IL-6 treatment, and IL-6-induced VEGF expression was abolished by the specific inhibitor and siRNA of ASK1, p38, and AP-1 cascades. Importantly, knockdown IL-6  reduced VEGF expression and abolished osteosarcoma conditional medium-mediated angiogenesis. Taken together, these results indicate that IL-6 occurs through ASK1 and p38, which in turn activates AP-1, resulting in the activations of VEGF  expression and contributing the angiogenesis of human osteosarcoma cells.

 

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[91]

TÍTULO / TITLE:  - Lifetime abuse victimization and risk of uterine leiomyomata in black women.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Obstet Gynecol. 2013 Jan 4. pii: S0002-9378(12)02313-7. doi: 10.1016/j.ajog.2012.12.034.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ajog.2012.12.034

AUTORES / AUTHORS:  - Wise LA; Palmer JR; Rosenberg L

INSTITUCIÓN / INSTITUTION:  - Slone Epidemiology Center at Boston University, Boston, MA. Electronic address: lwise@bu.edu.

RESUMEN / SUMMARY:  - OBJECTIVE: Uterine leiomyomata (UL) are a major contributor to gynecologic morbidity and medical costs, and black women are disproportionately affected by the condition. Previous studies have linked UL to psychosocial stress, including  child abuse. We assessed the association between lifetime abuse victimization and UL among 9910 premenopausal women. STUDY DESIGN: Data were derived from the Black Women’s Health Study, a prospective cohort study. In 2005, participants reported  their experiences of physical and sexual abuse within each life stage (childhood, adolescence, adulthood). Biennial follow-up questionnaires from 2005 through 2011 ascertained new UL diagnoses. Rate ratios (RRs) and 95% confidence intervals (CIs) were estimated using Cox regression. RESULTS: There were 1506 incident UL cases diagnosed by ultrasound or surgery. UL incidence was higher among women who reported child abuse, particularly sexual abuse. Relative to no abuse across the  life span, RRs were 1.16 (95% CI, 1.02-1.33) for physical abuse only, 1.34 (95% CI, 1.09-1.66) for sexual abuse only, and 1.17 (95% CI, 0.99-1.39) for both physical and sexual abuse in childhood. RRs for 1-3 and 4 or more incidents of child sexual abuse were 1.29 (95% CI, 1.04-1.61) and 1.41 (95% CI, 1.07-1.85), respectively, whereas the RRs for low, intermediate, and high frequencies of child physical abuse were 1.19, 1.04, and 1.23, respectively. The association was strongest for the highest category of child abuse severity (RR, 1.57; 95% CI, 1.19-2.07). No associations were found for teen or adult abuse. CONCLUSION: In the present study, child sexual abuse was an independent risk factor for UL, supporting the hypothesis that childhood adversity increases UL risk.

 

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[92]

TÍTULO / TITLE:  - Characterization of osteoblastic and osteolytic proteins in prostate cancer bone  metastases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Prostate. 2013 Jan 17. doi: 10.1002/pros.22639.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pros.22639

AUTORES / AUTHORS:  - Larson SR; Zhang X; Dumpit R; Coleman I; Lakely B; Roudier M; Higano CS; True LD; Lange PH; Montgomery B; Corey E; Nelson PS; Vessella RL; Morrissey C

INSTITUCIÓN / INSTITUTION:  - Department of Urology, University of Washington, Seattle, Washington.

RESUMEN / SUMMARY:  - BACKGROUND: Approximately 90% of patients who die of Prostate Cancer (PCa) have bone metastases, which promote a spectrum of osteoblastic, osteolytic or mixed bone responses. Numerous secreted proteins have been reported to promote osteoblastic or osteolytic bone responses. We determined whether previously identified and/or novel proteins were associated with the osteoblastic or osteolytic response in clinical specimens of PCa bone metastases. METHODS: Gene expression was analyzed on 14 PCa metastases from 11 patients by microarray profiling and qRT-PCR, and protein expression was analyzed on 33 PCa metastases from 30 patients by immunohistochemistry on highly osteoblastic and highly osteolytic bone specimens. RESULTS: Transcript and protein levels of BMP-2, BMP-7, DKK-1, ET-1, and Sclerostin were not significantly different between osteoblastic and osteolytic metastases. However, levels of OPG, PGK1, and Substance P proteins were increased in osteoblastic samples. In addition, Emu1, MMP-12, and sFRP-1 were proteins identified with a novel role of being associated with either the osteoblastic or osteolytic bone response. CONCLUSIONS: This is the first detailed analysis of bone remodeling proteins in human specimens of PCa bone metastases. Three proteins not previously shown to be involved may have a role in the PCa bone response. Furthermore, our data suggests that the relative expression of numerous, rather than a single, bone remodeling proteins determine  the bone response in PCa bone metastases. Prostate © 2013 Wiley Periodicals, Inc.

 

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[93]

TÍTULO / TITLE:  - miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Rep. 2013 Mar;29(3):1027-36. doi: 10.3892/or.2013.2234. Epub 2013 Jan 11.

            ●● Enlace al texto completo (gratuito o de pago) 3892/or.2013.2234

AUTORES / AUTHORS:  - Zhao H; Ma B; Wang Y; Han T; Zheng L; Sun C; Liu T; Zhang Y; Qiu X; Fan Q

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710038, P.R. China.

RESUMEN / SUMMARY:  - Osteosarcoma is the most common type of malignant bone tumor in children and adolescents and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. In this study, we investigated the role of miR-34a in the invasion and metastasis of osteosarcoma cells by examining its expression level and functional pattern in these cells. miR-34a mimics were transfected into the highly metastatic subline, F5M2, and into the F4 subline with low metastatic potential of the paired human osteosarcoma cell line, SOSP9607. Cell viability patterns, cell migration and alterations in gene expression levels were assessed by real-time PCR, and changes in protein levels were assessed by immunocytochemistry and western blot analysis. The ectopic overexpression of miR-34a significantly inhibited the migration and invasive ability of osteosarcoma cells by repressing the expression of CD44. These data suggest that miR-34a plays a tumor suppressor role in the metastasis of osteosarcoma cells by repressing the expression of CD44. Of note, studies have also suggested that the CD44 protein correlates with the metastatic potential of  several malignant tumors. Therefore, it can be concluded that through the inhibition of CD44 expression levels, miR-34a plays a significant role in the migration and invasion of osteosarcoma cells.

 

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[94]

TÍTULO / TITLE:  - Recurrent pneumonias secondary to an endobronchial inflammatory myofibroblastic tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Respir Crit Care Med. 2013 Jan 1;187(1):e1-2. doi: 10.1164/rccm.201202-0305IM.

            ●● Enlace al texto completo (gratuito o de pago) 1164/rccm.201202-0305IM

AUTORES / AUTHORS:  - Singh S; Dorfman SR; Nuctern JG; Popek EJ; Moore RH

 

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[95]

TÍTULO / TITLE:  - Lymphangioleiomyomatosis: calling it what it is: a low-grade, destructive, metastasizing neoplasm.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Respir Crit Care Med. 2012 Dec 15;186(12):1210-2. doi: 10.1164/rccm.201205-0848OE.

            ●● Enlace al texto completo (gratuito o de pago) 1164/rccm.201205-0848OE

AUTORES / AUTHORS:  - McCormack FX; Travis WD; Colby TV; Henske EP; Moss J

INSTITUCIÓN / INSTITUTION:  - Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1590. mossj@nhlbi.nih.gov.

 

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[96]

TÍTULO / TITLE:  - Inflammatory myofibroblastic tumor successfully treated with chemotherapy and nonsteroidals: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastroenterol. 2012 Dec 21;18(47):7100-3. doi: 10.3748/wjg.v18.i47.7100.

            ●● Enlace al texto completo (gratuito o de pago) 3748/wjg.v18.i47.7100

AUTORES / AUTHORS:  - Tao YL; Wang ZJ; Han JG; Wei P

INSTITUCIÓN / INSTITUTION:  - Yun-Lu Tao, Zhen-Jun Wang, Jia-Gang Han, Department of General Surgery, Chao Yang Hospital, Affiliated to Capital Medical University, Beijing 100020, China.

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumor (IMT) occurring at retroperitoneal sites has rarely been reported. We report the case of a previously well 14-year-old girl with no history of abdominal disease whose past medical history and family tumor  history were unremarkable. She complained of intermittent abdominal pain for one  month. An abdominal mass was found on physical examination and abdominal contrast-enhanced computed tomography (CT) showed a hypodense soft mass, the size and location of which suggested a well delineated retroperitoneal tumor surrounding the superior mesenteric vessels measuring 3.3 cm x 4.5 cm x 4.5 cm with enlarged lymph nodes. The patient underwent an exploratory laparotomy followed by biopsy and was subsequently diagnosed with retroperitoneal IMT. She was successfully treated with postoperative chemotherapy and oral diclofenac sodium. Following completion of therapy the mass was no longer palpable and no longer visible on CT scanning. The use of methotrexate and cisplatin for aggressive myofibroblastic tumors is also reviewed.

 

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[97]

TÍTULO / TITLE:  - Staging Paratesticular Rhabdomyosarcoma in the “As Low As Reasonably Achievable”  (ALARA) Age: The Case for Positron Emission Tomography-computed Tomography.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Urology. 2013 Jan 24. pii: S0090-4295(12)01554-3. doi: 10.1016/j.urology.2012.11.051.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.urology.2012.11.051

AUTORES / AUTHORS:  - Burnette JO; Klaassen Z; Hatley RM; Neunert CE; Williams H; Donohoe JM

INSTITUCIÓN / INSTITUTION:  - Section of Urology, Department of Surgery, Georgia Health Sciences University, Augusta, GA; (b)Section of Pediatric Surgery, Department of Surgery, Georgia Health Sciences University, Augusta, GA. Electronic address: jburnette@georgiahealth.edu.

RESUMEN / SUMMARY:  - Rhabdomyosarcoma accounts for 40% of paratesticular malignancies and 5% of testicular and paratesticular malignancies in children and adolescents. The Children’s Oncology Group currently recommends computed tomography (CT) or magnetic resonance imaging as modalities for staging paratesticular rhabdomyosarcoma in children. The present case illustrates a 9-year-old boy with  a paratesticular rhabdomyosarcoma who had a negative staging CT scan and a subsequent positron emission tomography-CT demonstrating retroperitoneal lymph node metastasis. In the era of “as low as reasonably achievable” (ALARA) imaging, positron emission tomography-CT should be considered as first-line staging imaging to improve sensitivity and specificity of staging for paratesticular rhabdomyosarcoma.

 

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[98]

TÍTULO / TITLE:  - Hydrogel-PLGA delivery system prolongs 2-methoxyestradiol-mediated anti-tumor effects in osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Biomed Mater Res A. 2013 Jan 27. doi: 10.1002/jbm.a.34550.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jbm.a.34550

AUTORES / AUTHORS:  - Maran A; Dadsetan M; Buenz CM; Shogren KL; Lu L; Yaszemski MJ

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN; Department of Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN. maran.avudai@mayo.edu.

RESUMEN / SUMMARY:  - Osteosarcoma is a bone tumor that affects children and young adults. 2-Methoxyestradiol (2-ME), a naturally occurring estrogen metabolite, kills osteosarcoma cells, but does not affect normal osteoblasts. In order to effectively target osteosarcoma and improve the therapeutic index of the drug 2-ME, we have encapsulated 2-ME in a composite of oligo-(polyethylene glycol) fumarate (OPF) hydrogel and poly (lactic-co-glycolic acid) (PLGA) microspheres and investigated the effect of polymer composition on 2-ME release kinetics and osteosarcoma cell survival. The in vitro study shows that 2-ME can be released in a controlled manner over 21-days. The initial burst releases observed on day 1 were 50% and 32% for OPF and OPF/PLGA composites, respectively. The extended release kinetics show that 100% of the encapsulated 2-ME is released by day 12 from OPF, whereas the OPF/PLGA composites showed a release of 85% on day 21. 2-ME released from the polymers was biologically active and blocked osteosarcoma cell  proliferation in vitro. Also, comparison of 2-ME delivery in osteosarcoma cells in culture, shows that direct treatment has no effect after 3 days, whereas polymer-mediated delivery produces anti-tumor effects that could be sustained for 21 days. These findings show that the OPF and PLGA polymeric system may prove to  be useful in controlled and sustained delivery of 2-ME and could be further explored in the treatment of osteosarcoma. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

 

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[99]

TÍTULO / TITLE:  - Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncogene. 2013 Jan 14. doi: 10.1038/onc.2012.590.

            ●● Enlace al texto completo (gratuito o de pago) 1038/onc.2012.590

AUTORES / AUTHORS:  - Yeung CL; Ngo VN; Grohar PJ; Arnaldez FI; Asante A; Wan X; Khan J; Hewitt SM; Khanna C; Staudt LM; Helman LJ

INSTITUCIÓN / INSTITUTION:  - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

RESUMEN / SUMMARY:  - To identify novel signaling pathways necessary for rhabdomyosarcoma (RMS) survival, we performed a loss-of-function screen using an inducible small hairpin RNA (shRNA) library in an alveolar and an embryonal RMS cell line. This screen identified CRKL expression as necessary for growth of alveolar RMS and embryonal  RMS both in vitro and in vivo. We also found that CRKL was uniformly highly expressed in both RMS cell lines and tumor tissue. As CRKL is a member of the CRK adapter protein family that contains an SH2 and two SH3 domains and is involved in signal transduction from multiple tyrosine kinase receptors, we evaluated CRKL interaction with multiple tyrosine kinase receptor signaling pathways in RMS cells. While we saw no interaction of CRKL with IGFIR, MET or PI3KAKT/mTOR pathways, we determined that CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES kinase. Inhibition of SFK signaling with dasatinib or another SFK inhibitor, sarcatinib, suppressed RMS cell growth in vitro and in vivo. These data identify CRKL as a novel critical component of RMS  growth. This study also demonstrates the use of functional screening to identify  a potentially novel therapeutic target and treatment approach for these highly aggressive pediatric cancers.Oncogene advance online publication, 14 January 2013; doi:10.1038/onc.2012.590.

 

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[100]

TÍTULO / TITLE:  - Hepatic angiomyolipoma: clinical, imaging and pathological features in 178 cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Mar;30(1):416. doi: 10.1007/s12032-012-0416-4. Epub 2013 Jan 6.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-012-0416-4

AUTORES / AUTHORS:  - Yang X; Li A; Wu M

INSTITUCIÓN / INSTITUTION:  - Division of Special Treatment II, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, 200438, China, ehbh_yangxy@163.com.

RESUMEN / SUMMARY:  - The aim of the study was to review the main clinical, imaging and pathological features of hepatic angiomyolipoma (HAML). We retrospectively analyzed the imaging, pathological and clinical features of 178 patients who underwent surgical resection for HAML. Forty-three males and 135 females with a median age  of 43.5 years (range: 17-76 years) were enrolled in the study. Routine blood tests, including those for alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen determinant, were normal. Liver function was classified as Child-Pugh A for all patients. Twenty-one patients were positive for hepatitis B  surface antigen (HBsAg), while two had liver cirrhosis. Seventy-five lesions were located in the right hepatic lobe, 42 in the left hepatic lobe, 12 in the hepatic caudal lobe, and 49 in both left and right lobe. All patients underwent examination by ultrasound sonography (US), and additional examinations by computed tomography (CT) and magnetic resonance (MR) were carried out for 115 and 81 patients, respectively. Various diseases including HAML, liver cancer, liver hemangioma, hepatic lipoma, hepatic hamartoma, focal nodular hyperplasia and liver adenoma were diagnosed before operation. CT and MRI are more conclusive than US (US vs CT: chi(2) = 17.72, P = 0.00; US vs MRI: chi(2) = 12.14, P = 0.00), but for the sensitivity of these three imaging modalities, MRI performs the best (US vs MRI: chi(2) = 5.938, P = 0.015; CT vs MRI: chi(2) = 2.544, P = 0.111). All the patients underwent liver resection (96 right hepatic lobectomy, 41 left hepatic lobectomy and nine caudal lobe hepatic lobectomy). Several sampled tissues were positive for HBsAg (21/168, 12.5 %), beta-catenin (4/41, 9.8 %), CD-34 (119/165, 72.1 %), HMB-45 (162/169, 92.9 %), SMA (145/158, 91.8 %) and  vimentin (20/27, 74.1 %). The diagnosis of HAML remains difficult and mainly relies on pathological findings. For the imaging modalities, we recommend MRI examination because of its better definition and sensitivity. Although HMB-45 is  considered the main histopathological biomarker for HAML, SMA may be also helpful in the diagnostic process (HMB-45 vs SMA: chi(2) = 2.37, P = 0.123). When the diagnosis of HAML is suspicious or hypothesized, surgical resection remains the recommended strategy due to the difficulty in diagnosis preoperatively and the potentially invasive growth of the lesion.

 

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[101]

TÍTULO / TITLE:  - Osteoblastic differentiation enhances expression of TRPV4 that is required for calcium oscillation induced by mechanical force.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bone. 2013 Jan 11. pii: S8756-3282(13)00007-0. doi: 10.1016/j.bone.2013.01.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bone.2013.01.001

AUTORES / AUTHORS:  - Suzuki T; Notomi T; Miyajima D; Mizoguchi F; Hayata T; Nakamoto T; Hanyu R; Kamolratanakul P; Mizuno A; Suzuki M; Ezura Y; Izumi Y; Noda M

INSTITUCIÓN / INSTITUTION:  - Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan; Global Center of Excellence (GCOE) Program, Tokyo Medical and Dental University, Japan; Department of Periodontology, Tokyo Medical and Dental University, Japan.

RESUMEN / SUMMARY:  - Mechanical stress is known to alter bone mass and the loss of force stimuli leads to reduction of bone mass. However, molecules involved in this phenomenon are incompletely understood. As mechanical force would affect signaling events in cells, we focused on a calcium channel, TRPV4 regarding its role in the effects of force stimuli on calcium in osteoblasts. TRPV4 expression levels were enhanced upon differentiation of osteoblasts in culture. We found that BMP2 treatment enhanced TRPV4 gene expression in a dose dependent manner. BMP effects on TRPV4 expression were suppressed by inhibitors for transcription and new protein synthesis. In these osteoblasts, a TRPV4-selective agonist, 4alpha-PDD, enhanced  calcium signaling and the effects of 4alpha-PDD were enhanced in differentiated osteoblasts compared to the control cells. Fluid flow, as a mechanical stimulation, induced intracellular calcium oscillation in wild type osteoblasts.  In contrast, TRPV4 deficiency suppressed calcium oscillation significantly even when the cells were subjected to fluid flow. These data suggest that TRPV4 is involved in the flow-induced calcium signaling in osteoblasts.

 

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[102]

TÍTULO / TITLE:  - A new synthesis pathway for colloidal silica spheres coated with crystalline titanium oxide and its comparative cyto- and genotoxic study with titanium oxide  nanoparticles in rat osteosarcoma (UMR106) cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Colloid Interface Sci. 2012 Nov 29. pii: S0021-9797(12)01292-1. doi: 10.1016/j.jcis.2012.11.005.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcis.2012.11.005

AUTORES / AUTHORS:  - Di Virgilio AL; Maisuls I; Kleitz F; Arnal PM

INSTITUCIÓN / INSTITUTION:  - CEQUINOR and Catedra de Bioquimica Patologica, Facultad de Ciencias Exactas, UNLP. 47 y 115 (1900) La Plata, Argentina.

RESUMEN / SUMMARY:  - Spherical particles with an amorphous core of silica and a crystalline shell of titanium oxide (SiO(2)@TiO(2)) formed in a three-step procedure, being the last step a mild chemical treatment. SiO(2)@TiO(2) had a shell with pores (micro and mesopores) permeating between TiO(2) nanocrystals (anatase) and a solid core of amorphous silica. The spheres had an outstanding specific surface area (300m(2)g(-1)). A cyto- and genotoxic study of SiO(2)@TiO(2) and titanium oxide nanoparticles (TiO(2)-NP) on UMR106 cells with 24h exposure showed that SiO(2)@TiO(2) colloidal particles were less toxic than TiO(2)-NP.

 

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[103]

TÍTULO / TITLE:  - MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genes Chromosomes Cancer. 2013 Mar;52(3):297-304. doi: 10.1002/gcc.22029. Epub 2012 Dec 8.

            ●● Enlace al texto completo (gratuito o de pago) 1002/gcc.22029

AUTORES / AUTHORS:  - Markowski DN; Huhle S; Nimzyk R; Stenman G; Loning T; Bullerdiek J

INSTITUCIÓN / INSTITUTION:  - Center of Human Genetics, University of Bremen, Leobener Strasse ZHG, D-28359 Bremen, Germany.

RESUMEN / SUMMARY:  - Mutations of the mediator subcomplex 12 gene (MED12) recently have been described in a large group of uterine leiomyomas (UL) but only in a single malignant uterine smooth muscle tumor. To further address the occurrence of fibroid-type MED12 mutations in smooth muscle tumors, we have analyzed samples from 34 leiomyosarcomas (LMS), 21 UL, two extrauterine leiomyomas (EL), and 10 canine genital leiomyomas for the presence of MED12 mutations of the UL-type. Interestingly, besides UL MED12 mutations were found in one uterine LMS, one EL,  and two canine vaginal leiomyomas. The results confirm the occurrence of fibroid-type MED12 mutations in malignant uterine smooth muscle tumors thus suggesting a rare but existing leiomyoma-LMS sequence. In addition, for the first time MED12 mutations are reported in smooth muscle tumors in a non-primate mammalian species. © 2012 Wiley Periodicals, Inc.

 

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[104]

TÍTULO / TITLE:  - TWIST interacts with beta-catenin signaling on osteosarcoma cell survival against cisplatin.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Carcinog. 2012 Dec 31. doi: 10.1002/mc.21991.

            ●● Enlace al texto completo (gratuito o de pago) 1002/mc.21991

AUTORES / AUTHORS:  - Wu J; Liao Q; He H; Zhong D; Yin K

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Spine, Xiangya Hospital, Central South University, Changsha, Hunan, China.

RESUMEN / SUMMARY:  - Both TWIST and Wnt/beta-catenin signaling reportedly play important roles in osteosarcoma development. In the present study, we explored the regulatory effect of TWIST on beta-catenin in osteosarcoma cells and assessed how the functional interaction between TWIST and beta-catenin would impact osteosarcoma cell survival against chemotherapy agent cisplatin. Overexpression and knockdown of TWIST were respectively performed in Saos-2 and MG-63 osteosarcoma cells. Overexpression of TWIST in Saos-2 cells significantly decreased the soluble beta-catenin level, phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at serine 9, the mRNA level of beta-catenin signaling target genes, and cell survival against cisplatin, which was strengthened by knocking down beta-catenin. Knockdown of TWIST in MG-63 cells significantly increased the soluble beta-catenin level, phosphorylation of GSK-3beta at serine 9, the mRNA level of beta-catenin signaling target genes, and cell survival against cisplatin, which was reversed by knocking down beta-catenin or phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002. In conclusion, we demonstrate that TWIST decreases osteosarcoma cell survival against cisplatin by decreasing the soluble beta-catenin level through a PI3K-dependent manner. This study provides the first evidence of a functional link between TWIST and beta-catenin signaling in osteosarcoma cells, which adds fresh insights into the molecular mechanism of osteosarcoma development. © 2012 Wiley Periodicals, Inc.

 

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[105]

TÍTULO / TITLE:  - Lipomatous salivary gland tumors: a series of 31 cases spanning their morphologic spectrum with emphasis on sialolipoma and oncocytic lipoadenoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2013 Jan;37(1):128-37. doi: 10.1097/PAS.0b013e31826731e0.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e31826731e0

AUTORES / AUTHORS:  - Agaimy A; Ihrler S; Markl B; Lell M; Zenk J; Hartmann A; Michal M; Skalova A

INSTITUCIÓN / INSTITUTION:  - Pathologisches Institut, Universitatsklinikum Erlangen, Krankenhausstrae 8-10, 91054 Erlangen, Germany. abbas.agaimy@uk-erlangen.de

RESUMEN / SUMMARY:  - Lipomatous neoplasms of the salivary glands are rare. Their wide histologic spectrum has not been sufficiently studied. We collected 31 fat-containing salivary gland lesions excluding pleomorphic adenoma and myoepithelioma with lipometaplasia. There were 19 male and 12 female patients aged 7 to 89 years (mean, 53 y). Tumors originated in the parotid (n=29) and the submandibular (n=2) gland. On the basis of the proportion and distribution of adipose tissue and the  epithelial type, tumors could be categorized into 3 main groups: ordinary lipoma  (n=20) identical to soft tissue lipoma but located within the salivary gland, oncocytic lipoadenoma (n=6) composed predominantly of oncocytes with variable fatty component, nononcocytic sialolipoma (n=4) composed of lobular fatty tissue  (>/=70%) with evenly distributed normal salivary tissue recapitulating the composition of normal salivary glands and microcystic lipoadenoma (n=1) composed  of cystic ducts admixed with adipose tissue. The mean tumor size was 3.3, 3.8, and 2.9 cm for lipoma, oncocytic lipoadenoma, and nononcocytic sialolipoma, respectively. Associated diseases included Madelung disease with bilateral atypical lipomatous tumors of the neck and bilateral parotid lipoma (1), oncocytic lipoadenoma after irradiation for sinonasal adenocarcinoma (1), and periparotideal lipoma excised years before oncocytic lipoadenoma (1) and nononcocytic sialolipoma (1). No recurrence was recorded at a mean follow-up of 72 months (range, 6 to 184 mo). Sebaceous islands were seen in 5/6 oncocytic lipoadenomas and in 2/4 sialolipomas. Periductal inflammation/fibrosis was common in sialolipoma and oncocytic lipoadenoma. This study demonstrates the wide morphologic spectrum of fatty salivary gland lesions. Oncocytic lipoadenoma is an epithelial-predominant tumor that is distinct from the fat-dominated nononcocytic sialolipoma, but the 2 types seem to merge in some cases.

 

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[106]

TÍTULO / TITLE:  - Kaposi’s sarcoma: a computational approach through protein-protein interaction and gene regulatory networks analysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Virus Genes. 2012 Dec 25.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11262-012-0865-z

AUTORES / AUTHORS:  - Zaman A; Rahaman MH; Razzaque S

INSTITUCIÓN / INSTITUTION:  - Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka,  1000, Bangladesh, aubhishek@gmail.com.

RESUMEN / SUMMARY:  - Interactomic data for Kaposi’s Sarcoma Associated Herpes virus (KSHV)-the causative agent of vascular origin tumor called Kaposi’s sarcoma-is relatively modest to date. The objective of this study was to assign functions to the previously uncharacterized ORFs in the virus using computational approaches and subsequently fit them to the host interactome landscape on protein, gene, and cellular level. On the basis of expression data, predicted RNA interference data, reported experimental data, and sequence based functional annotation we also tried to hypothesize the ORFs role in lytic and latent cycle during viral infection. We studied 17 previously uncharacterized ORFs in KSHV and the host-virus interplay seems to work in three major functional pathways-cell division, transport, metabolic and enzymatic in general. Studying the host-virus  crosstalk for lytic phase predicts ORF 10 and ORF 11 as a predicted virus hub whereas PCNA is predicted as a host hub. On the other hand, ORF31 has been predicted as a latent phase inducible protein. KSHV invests a lion’s share of its coding potential to suppress host immune response; various inflammatory mediators such as IFN-gamma, TNF, IL-6, and IL-8 are negatively regulated by the ORFs while Il-10 secretion is stimulated in contrast. Although, like any other computational prediction, the study requires further validation, keeping into account the reproducibility and vast sample size of the systems biology approach the study allows us to propose an integrated network for host-virus interaction with good confidence. We hope that the study, in the long run, would help us identify effective dug against potential molecular targets.

 

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[107]

TÍTULO / TITLE:  - G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pathol. 2013 Jan 21. doi: 10.1002/path.4170.

            ●● Enlace al texto completo (gratuito o de pago) 1002/path.4170

AUTORES / AUTHORS:  - Richter GH; Fasan A; Hauer K; Grunewald TG; Berns C; Rossler S; Naumann I; Staege MS; Fulda S; Esposito I; Burdach S

INSTITUCIÓN / INSTITUTION:  - Children’s Cancer Research Center and Department of Paediatrics, Roman Herzog Comprehensive Cancer Research Center and Klinikum rechts der Isar, Technische Universitat Munchen, 81664, Munich.

RESUMEN / SUMMARY:  - Metastatic spread in Ewing sarcomas (ES) is frequent and haematogenous. G-protein coupled receptor 64 (GPR64), an orphan receptor with normal expression restricted to human epididymis is specifically over-expressed in ES among sarcoma, but also  up-regulated in a number of carcinomas derived from prostate, kidney or lung. Inhibition of GPR64 expression in ES by RNA interference impaired colony formation in vitro and suppressed local tumour growth and metastasis in Rag2(-/-) gamma© (-/-) mice. Microarray analysis after GPR64 knock down revealed a GPR64-mediated repression of genes involved in neuronal development like SLIT, drosophila, homolog of, 2 (SLIT2), and genes regulating transcription including pre-B cell leukemia homeobox 2 (PBX2). Concurrently, the suppression of GPR64 increased ES susceptibility to TRAIL induced apoptosis. Moreover, a GPR64-mediated induction of placental growth factor (PGF) in ES was observed. PGF suppression by RNA interference resulted in a reduction of metastatic growth similar to that observed after GPR64 knock down. Importantly, inhibition of GPR64 as well as PGF expression was associated with a reduced expression of matrix metalloproteinase (MMP) 1 and invasiveness in vitro. Furthermore, MMP1 knock down abrogated lung metastasis in Rag2(-/-) gamma© (-/-) mice. Thus, GPR64 expression in ES maintains an immature phenotype that is less sensitive to TRAIL-induced apoptosis and via its up-regulation of PGF and MMP1 orchestrates and promotes invasiveness and metastatic spread.

 

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[108]

TÍTULO / TITLE:  - Resveratrol induces MMP-9 and cell migration via the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Rep. 2013 Feb;29(2):826-34. doi: 10.3892/or.2012.2151. Epub 2012 Nov 27.

            ●● Enlace al texto completo (gratuito o de pago) 3892/or.2012.2151

AUTORES / AUTHORS:  - Gweon EJ; Kim SJ

INSTITUCIÓN / INSTITUTION:  - Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Chungnam 314-701, Republic of Korea.

RESUMEN / SUMMARY:  - Trans-3,4’,5-trihydroxystilbene (resveratrol) is a grape polyphenol present in various plants, food products, red wine and grapes. Resveratrol has anti-inflammatory, anticarcinogenic, anti-oxidant and anti-aging properties. Matrix metalloproteinases (MMPs) are key enzymes involved in the degradation of the extracellular matrix, and their expression may be regulated in cancer metastasis. In the present study, we aimed to evaluate the effect of resveratrol  on MMPs and cell migration, and to understand the mechanism of action in HT1080 human fibrosarcoma cells. We found that resveratrol inhibited HT1080 cell viability at various concentrations as detected by the MTT assay and FACS analysis. However, resveratrol dramatically increased the activation and expression of MMP-9 in a dose- and time-dependent manner, as determined by gelatin zymography assay and western blot analysis. We also discovered that resveratrol enhanced the migratory ability of HT1080 cells, as determined by the  wound healing assay, and decreased the phosphorylation of p38 kinase. Moreover, the Akt kinase was inhibited by resveratrol in the HT1080 cells. The inhibition of p38 and Akt kinases with SB203580 and LY294002 further increased resveratrol-induced MMP-9 as well as cell migration in the HT1080 cells. Our results suggest that resveratrol regulates MMP-9 and migratory abilities through  the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells.

 

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[109]

TÍTULO / TITLE:  - Immunohistochemical Loss of Succinate Dehydrogenase Subunit A (SDHA) in Gastrointestinal Stromal Tumors (GISTs) Signals SDHA Germline Mutation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2013 Feb;37(2):234-40. doi: 10.1097/PAS.0b013e3182671178.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e3182671178

AUTORES / AUTHORS:  - Miettinen M; Killian JK; Wang ZF; Lasota J; Lau C; Jones L; Walker R; Pineda M; Zhu YJ; Kim SY; Helman L; Meltzer P

INSTITUCIÓN / INSTITUTION:  - *Laboratory of Pathology double daggerPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute daggerGenetics Branch of the National  Institutes of Health/National Cancer Institute, Bethesda, MD.

RESUMEN / SUMMARY:  - A subset (7% to 10%) of gastric gastrointestinal stromal tumors (GISTs) is notable for the immunohistochemical loss of succinate dehydrogenase (SDH) subunit B (SDHB), which signals the loss of function of the SDH complex consisting of mitochondrial inner membrane proteins. These SDH-deficient GISTs are known to be  KIT/PDGFRA wild type, and most patients affected by this subset of GISTs are young. Some of these patients have germline mutations of SDH subunit genes SDHB,  SDHC, or SDHD, known as Carney-Stratakis syndrome when combined with paraganglioma. More recently, germline mutations in SDH subunit A gene (SDHA) have also been reported in few patients with KIT/PDGFRA wild-type GISTs. In this  study we immunohistochemically examined 127 SDHB-negative and 556 SDHB-positive gastric GISTs and 261 SDHB-positive intestinal GISTs for SDHA expression using a  mouse monoclonal antibody 2E3 (Abcam). Cases with available DNA were tested for SDHA, SDHB, SDHC, and SDHD gene mutations using a hybridization-based custom capture next-generation sequencing assay. A total of 36 SDHA-negative GISTs (28%) were found among 127 SDHB-negative gastric GISTs. No SDHB-positive GIST was SDHA  negative. Among 7 SDHA-negative tumors analyzed, there were 7 SDHA mutants, most  germline. A second hit indicating biallelic inactivation of SDHA was present in 6 of those cases. These patients had no other SDH subunit gene mutations. Among the 25 SDHA-positive, SDHB-negative GISTs analyzed, we identified 3 SDHA mutations (1 germline), and 11 SDHB, SDHC, or SDHD mutations (mostly germline), and 11 patients with no SDH mutations. Compared with patients with SDHA-positive GISTs,  those with SDHA-negative GISTs had an older median age (34 vs. 21 y), lower female to male ratio (1.8 vs. 3.1) but similar mitotic counts and median tumor sizes, with a slow course of disease in most cases, despite a slightly higher rate of liver metastases. SDHA-negative GISTs comprise approximately 30% of SDHB-negative/SDH-deficient GISTs, and SDHA loss generally correlates with SDHA mutations.

 

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[110]

TÍTULO / TITLE:  - Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Food Chem Toxicol. 2012 Dec 22;53C:325-333. doi: 10.1016/j.fct.2012.12.019.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.fct.2012.12.019

AUTORES / AUTHORS:  - Zhang Y; Song L; Cai L; Wei R; Hu H; Jin W

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

RESUMEN / SUMMARY:  - Baicalein is a bioactive flavonoid that is widely used in ancient China. However, its effects on the most common primary malignant bone tumor, osteosarcoma, remain unknown. In the present study, we investigated the effects of baicalein in osteosarcoma cells. Our results indicate baicalein might be an efficacious anti-osteosarcoma drug. We found that baicalein could inhibit cell proliferation  in a time- and dose-dependent manner. Additionally, we demonstrated that baicalein promotes osteosarcoma cell apoptosis, and our mechanistic studies suggest that this is mediated by caspase activation, especially caspase-3. We also showed that the down-regulation of Bcl-2 and concurrent increase in Bax and  Bim levels contribute to the apoptosis induced by baicalein. In addition, we observed that baicalein induces G1 cell cycle arrest by decreasing cyclin D1 and  cyclin-dependent kinase 4 (CDK4). Furthermore, our data verifies that baicalein can reduce osteosarcoma cell adhesion, migration and invasion in vitro, which indicates its potential to inhibit osteosarcoma metastasis. The decrease in expression of matrix metalloproteinases (MMP)-2 and MMP-9 may contribute to the effects of baicalein. Taken together, our results provide evidence that baicalein plays important roles in anti-osteosarcoma therapy, and thus may serve as a novel and efficient candidate agent for osteosarcoma treatment.

 

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[111]

TÍTULO / TITLE:  - Altered matrix mineralization in a case of a sclerosing osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bone. 2013 Jan 2. pii: S8756-3282(12)01461-5. doi: 10.1016/j.bone.2012.12.043.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bone.2012.12.043

AUTORES / AUTHORS:  - Hofstaetter JG; Roschger A; Puchner S; Dominkus M; Sulzbacher I; Windhager R; Klaushofer K; Roschger P

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Dept. Hanusch Hospital, Vienna, Austria. Electronic address: jochen.hofstaetter@meduniwien.ac.at.

RESUMEN / SUMMARY:  - Little is known about the tumor matrix mineralization of highly sclerotic osteosarcoma. We used quantitative backscattered electron imaging (qBEI) to determine the Bone mineralization density distribution (BMDD) of a highly sclerosing osteosarcoma of the proximal tibia as well as adjacent normal bone of  a 10-year-old girl following chemotherapy according to the EURAMOS-1 protocol. Data were compared to recently published normative reference data for young individuals. Backscattered electron imaging of the tumor region revealed a dense  accumulation of mineralized tumor bone matrix (up to 90% of the medullar space).  The BMDD was shifted tremendously towards higher matrix mineralization (CaMean +18.5%, CaPeak +22.5%, CaHigh +100 fold) compared to normal bone. Additionally the BMDD became much wider, indicating a higher heterogeneity in mineralization (CaWidth +40%). In contrast to lamellar bone, which mineralizes via a mineralization front, the mineralization of the tumor matrix starts by randomly distributed spots of mineral clusters fusing together to a highly mineralized non-lamellar bone matrix. We also found an altered BMDD of the patient’s normal bone when compared with the reference BMDD of young individuals. In conclusion this high radiodensity region of the sclerosing sarcoma is not only due to the high amount of tumor matrix but also to its high mineralization density. Chemotherapy may lead to altered matrix mineralization of normal bone due to suppression of bone turnover. The mechanism of matrix mineralization in a sclerosing osteosarcoma warrants further studies.

 

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[112]

TÍTULO / TITLE:  - Case 190: papillary fibroelastoma of the pulmonary valve.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Radiology. 2013 Feb;266(2):680-4. doi: 10.1148/radiol.12110495.

            ●● Enlace al texto completo (gratuito o de pago) 1148/radiol.12110495

AUTORES / AUTHORS:  - van Werkum MH; Swaans MJ; van Es HW; Rensing B; van Heesewijk JP

INSTITUCIÓN / INSTITUTION:  - Departments of Radiology and Cardiology, St Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, the Netherlands.

 

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[113]

TÍTULO / TITLE:  - LETTER TO THE EDITOR: Kaposi’s Sarcoma After Non-Myeloablative Hematopoietic Stem Cell Transplant: Response to Withdrawal of Immunosuppressant Therapy Correlated with Whole Blood Human Herpes Virus-8 RT-PCR levels.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Leuk Lymphoma. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 3109/10428194.2013.769221

AUTORES / AUTHORS:  - Deauna-Limayo D; Rajabi B; Qiu W; Htut M; Sweetenham J

 

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[114]

TÍTULO / TITLE:  - Outcomes analysis of the role of plastic surgery in extremity sarcoma treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Reconstr Microsurg. 2013 Feb;29(2):107-12. doi: 10.1055/s-0032-1329920. Epub 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 1055/s-0032-1329920

AUTORES / AUTHORS:  - Agrawal N; Wan D; Bryan Z; Boehmler J; Miller M; Tiwari P

INSTITUCIÓN / INSTITUTION:  - Department of Plastic Surgery, Ohio State University, Columbus, Ohio.

RESUMEN / SUMMARY:  - Over the past 5 years we have developed a multidisciplinary service for the treatment of extremity sarcoma. This service includes orthopedic oncology, neurosurgery, medical and radiation oncology, and plastic surgery. Prior to 2007, the role of plastic surgery in this multidisciplinary team was limited. After 2007, plastic surgery at our institution played an increasingly integral role in  multidisciplinary care. Based on the development of the plastic surgery service at our institution, we were able to evaluate the role of plastic surgery in the outcomes following extremity reconstruction after sarcoma resection. We hypothesize that plastic surgery involvement would reduce the amputation rate without altering recurrence rates. We found a decrease in lower-extremity amputation of approximately 20% without any significant change in recurrence rates. The incidence of infectious complications requiring IV antibiotics decreased by about 20%. The incidence of skin graft loss decreased by 75%. We do  report a significant increase in partial flap necrosis. Overall, plastic surgery  is an essential component of the multidisciplinary team in the care of extremity  sarcoma.

 

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[115]

TÍTULO / TITLE:  - Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Feb;44(2):289-93. doi: 10.1016/j.humpath.2012.08.008. Epub 2012  Nov 27.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.08.008

AUTORES / AUTHORS:  - Thway K; Stefanaki K; Papadakis V; Fisher C

INSTITUCIÓN / INSTITUTION:  - Department of Histopathology, Royal Marsden Hospital, SW3 6JJ London, UK. Electronic address: khin.thway@rmh.nhs.uk.

RESUMEN / SUMMARY:  - Angiomatoid fibrous histiocytoma is a rare soft tissue tumor of intermediate biologic potential, predominantly arising in superficial extremities of children  and young adults. Less than 5% metastasize. We describe a case of angiomatoid fibrous histiocytoma in the scalp of an 8-year-old boy, which metastasized to a postauricular lymph node 3 years after primary tumor excision. Histologically, primary and metastasis comprised nodules of bland ovoid cells, with primary additionally showing hemorrhagic cavities, fibrous capsule, and lymphoplasmacytic inflammation. Both strongly expressed desmin, with focal epithelial membrane antigen. Reverse transcription-polymerase chain reaction showed EWSR1-CREB1 fusion transcripts in both primary and metastasis. This is, to our knowledge, the first description of genetically proven metastatic angiomatoid fibrous histiocytoma. Angiomatoid fibrous histiocytoma can mimic both benign and malignant lesions, and although most behave indolently, it is important to recognize their metastatic potential.

 

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[116]

TÍTULO / TITLE:  - Endotracheobronchial neurofibroma treated by right carinal pneumonectomy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Surg. 2013 Feb;95(2):e35-7. doi: 10.1016/j.athoracsur.2012.07.083.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.athoracsur.2012.07.083

AUTORES / AUTHORS:  - Feng J; Mao T; Zhao Y; Chen W; Wu J; Fang W

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

RESUMEN / SUMMARY:  - Neurofibromas arising from the trachea and bronchus are relatively rare. We report the case of a 42-year-old woman who came to our hospital with severe shortness of breath. Right sleeve pneumonectomy was performed, and neurofibroma was confirmed by pathologic examination. In a search of the world literature, 28  cases of endotracheobronchial neurofibromas were found. The literature is reviewed.

 

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[117]

TÍTULO / TITLE:  - Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Toxicology. 2013 Jan 8;304C:120-131. doi: 10.1016/j.tox.2012.12.018.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.tox.2012.12.018

AUTORES / AUTHORS:  - Liu Y; Wang L; Wu Y; Lv C; Li X; Cao X; Yang M; Feng D; Luo Z

INSTITUCIÓN / INSTITUTION:  - Institute of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, China.

RESUMEN / SUMMARY:  - Osteosarcoma is a high-grade malignant bone tumor. Pterostilbene (PTE) is a natural, dimethylated analog of resveratrol with higher bioavailability. While PTE has been shown to have potent antitumor activity against various types of cancer, the molecular mechanisms underlying the effects of PTE remain largely unknown. The Janus kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling pathway plays a crucial role in tumorigenesis and immune development. In this study, we assessed the antitumor activity of PTE against human osteosarcoma cells and explored the role of JAK2/STAT3 and apoptosis-related signaling pathways on the activity of PTE. PTE treatment resulted in a dose- and time-dependent inhibition of osteosarcoma cell viability. Additionally, PTE exhibited strong antitumor activity, as evidenced not only by reductions in tumor cell adhesion, migration and mitochondrial membrane potential (MMP) but also by increases in the apoptotic index, reactive oxygen species (ROS) and several biochemical parameters. Furthermore, PTE treatment directly inhibited the phosphorylation of JAK2 at Tyr 1007 and the downstream activation of STAT3. PTE also down-regulated the expression of STAT3 target genes, including the anti-apoptotic proteins Bcl-xL and Mcl-1, leading to the up-regulation of mitochondrial apoptosis pathway-related proteins (Bax, Bak, cytosolic Cytochrome  c, and cleaved Caspase3) and cyclin-dependent kinase inhibitors such as p21 and p27. PTE, used in combination with a known JAK2/STAT3 inhibitor, AG490, further decreased the viability of osteosarcoma cells. Taken together, PTE is a potent inhibitor of osteosarcoma cell growth that targets the JAK2/STAT3 signaling pathway. These data suggest that inhibition of JAK2/STAT3 signaling is a novel mechanism of action for PTE during therapeutic intervention in osteosarcoma cancers.

 

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[118]

TÍTULO / TITLE:  - Risk of subsequent primary malignancies after dermatofibrosarcoma protuberans diagnosis: A national study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Am Acad Dermatol. 2012 Dec 20. pii: S0190-9622(12)01176-0. doi: 10.1016/j.jaad.2012.10.040.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jaad.2012.10.040

AUTORES / AUTHORS:  - Kurlander DE; Martires KJ; Chen Y; Barnholtz-Sloan JS; Bordeaux JS

INSTITUCIÓN / INSTITUTION:  - Case Western Reserve University School of Medicine, Cleveland, Ohio.

RESUMEN / SUMMARY:  - BACKGROUND: Patients frequently live many years after diagnosis of dermatofibrosarcoma protuberans (DFSP). OBJECTIVE: We sought to determine the risk of subsequent primary malignancy (SPM) after DFSP diagnosis. METHODS: Using  the Surveillance, Epidemiology, and End Results database (1973-2008) for 3734 patients with DFSP, we compared the risk of developing 14 SPMs (12 most prevalent cancers in the United States plus other nonepithelial and soft tissue) relative to risk in the general population of same sex, race, and age and year of diagnosis. RESULTS: Patients given the diagnosis of DFSP had an overall increased risk of SPM (observed:expected [O:E], 1.20; 95% confidence intervals [CI], 1.04-1.39), with much of the overall increased risk attributable to increased risk of nonepithelial skin cancer (O:E, 9.94; 95% CI, 3.38-22.30). Specifically,  female patients with DFSP were at increased risk of other nonepithelial skin cancer (O:E, 14.50; 95% CI, 3.46-38.98), melanoma (O:E, 2.59; 95% CI, 1.02-5.35), and breast cancer (O:E, 1.44; 95% CI, 1.00-2.00). Male patients were not at increased overall risk (O:E, 1.18; 95% CI, 0.96-1.44) of SPM or at increased risk of any specific malignancy (P > .05) adjusted for multiplicity of t tests. LIMITATIONS: Surveillance bias may have led to increased rates and earlier detection of primary malignances in patients with DFSP compared with the general  population. Individual data that may reveal shared environmental causes of DFSP and SPM were unavailable. CONCLUSIONS: Patients with DFSP are at increased risk of a number of SPMs.

 

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[119]

TÍTULO / TITLE:  - Topical imiquimod 5% as a treatment for localized genital Kaposi’s sarcoma in an  HIV-negative man: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J STD AIDS. 2012 Dec;23(12):907-8. doi: 10.1258/ijsa.2012.012074.

            ●● Enlace al texto completo (gratuito o de pago) 1258/ijsa.2012.012074

AUTORES / AUTHORS:  - Fairley JL; Denham I; Yoganathan S; Read TR

INSTITUCIÓN / INSTITUTION:  - Faculty of Medicine, Nursing and Health Sciences, Monash University.

RESUMEN / SUMMARY:  - We report a case of Kaposi’s sarcoma (KS) in an HIV-negative man who has sex with men (MSM) that was successfully treated by topical application of imiquimod 5% cream (Aldara). Our case highlights a potentially effective and non-invasive method of treatment of Kaposi’s sarcoma in the shortest timeframe yet recorded. The location of the lesions on the patient’s penis also highlights the need for a non-invasive treatment.

 

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[120]

TÍTULO / TITLE:  - Predictors of Survival and Recurrence in Primary Leiomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Surg Oncol. 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1245/s10434-013-2876-y

AUTORES / AUTHORS:  - Gladdy RA; Qin LX; Moraco N; Agaram NP; Brennan MF; Singer S

INSTITUCIÓN / INSTITUTION:  - Sarcoma Disease Management Team, Department of Surgery, Memorial Sloan-Kettering  Cancer Center, New York, NY, USA.

RESUMEN / SUMMARY:  - BACKGROUND: Leiomyosarcoma is a soft tissue sarcoma whose outcome has historically been confounded by the inclusion of gastrointestinal stromal tumors. Thus, we sought to determine the factors that predict survival and recurrence in  patients with primary leiomyosarcoma alone. METHODS: During 1982-2006, a total of 353 patients with primary resectable leiomyosarcoma were identified from a prospective database. Multivariate analysis was used to assess clinicopathologic  factors for association with disease-specific survival (DSS). Competing risk survival analysis was used to determine factors predictive for local and distant  recurrence. RESULTS: Of 353 patients, 170 (48 %) presented with extremity, 144 (41 %) with abdominal/retroperitoneal, and 39 (11 %) with truncal tumors. Median  age was 57 (range, 18-88) years, and median follow-up was 50 (range, 1-270) months. Most tumors were high grade (75 %), deep (73 %), and completely resected  (97 %); median size was 6.0 (range, 0.3-45) cm. Abdominal/retroperitoneal location was associated with worse long-term DSS compared to extremity or trunk (P = 0.005). However, by multivariate analysis, only high grade and size were significant independent predictors of DSS. Overall, 139 patients (39 %) had recurrence: 51 % of those with abdominal/retroperitoneal, 33 % of extremity, and  26 % of truncal disease. Significant independent predictors for local recurrence  were size and margin, whereas predictors for distant recurrence were size and grade. Site was not an independent predictor of recurrence; however, late recurrence (>5 years) occurred in 9 % of abdominal/retroperitoneal and 4 % of extremity lesions. CONCLUSIONS: Grade and size are significant independent predictors of DSS and distant recurrence. Long-term follow-up in leiomyosarcoma is important, as late recurrence continues in 6-9 % patients.

 

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[121]

TÍTULO / TITLE:  - Value of MR Imaging in Differentiation between Solitary Fibrous Tumor and Schwannoma in the Orbit.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - AJNR Am J Neuroradiol. 2013 Jan 10.

            ●● Enlace al texto completo (gratuito o de pago) 3174/ajnr.A3340

AUTORES / AUTHORS:  - Zhang Z; Shi J; Guo J; Yan F; Fu L; Xian J

INSTITUCIÓN / INSTITUTION:  - Departments of Radiology and Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

RESUMEN / SUMMARY:  - BACKGROUND AND PURPOSE:Orbital SFT is a rare tumor, often misdiagnosed as orbital schwannoma preoperatively but with different prognosis and treatment. Our aim was to evaluate MR imaging features that might distinguish orbital SFT from schwannoma.MATERIALS AND METHODS:MR imaging including DCE scanning was performed  in 9 patients with SFT and 22 patients with schwannoma in the orbit confirmed by  pathology. Location, shape, margin, signal intensity, homogeneity, enhancement pattern, ER, and TIC of the tumors were retrospectively evaluated.RESULTS:There was a statistically significant difference between SFT and schwannoma in location and T2 signal intensity (P < .05). A statistically significant difference was also found regarding the enhancement pattern of the very high-signal-intensity areas shown on T2-weighted imaging and the type of TICs (P < .01).CONCLUSIONS:MR  imaging is useful in differentiating orbital SFT and schwannoma. The enhancement  pattern of the very high-signal-intensity areas shown on T2-weighted imaging and  the type of TICs on DCE MR imaging played an important role in differentiating orbital SFT from schwannoma.

 

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[122]

TÍTULO / TITLE:  - Giant cell tumor of bone: review, mimics, and new developments in treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Radiographics. 2013 Jan;33(1):197-211. doi: 10.1148/rg.331125089.

            ●● Enlace al texto completo (gratuito o de pago) 1148/rg.331125089

AUTORES / AUTHORS:  - Chakarun CJ; Forrester DM; Gottsegen CJ; Patel DB; White EA; Matcuk GR Jr

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Keck School of Medicine, University of Southern California, 1500 San Pablo St, 2nd Floor Imaging, Los Angeles, CA 90033-5313.

RESUMEN / SUMMARY:  - Giant cell tumor (GCT) of bone is generally a benign tumor composed of mononuclear stromal cells and characteristic multinucleated giant cells that exhibit osteoclastic activity. It usually develops in long bones but can occur in unusual locations. The typical appearance is a lytic lesion with a well-defined but nonsclerotic margin that is eccentric in location, extends near the articular surface, and occurs in patients with closed physes. However, GCT may have aggressive features, including cortical expansion or destruction with a soft-tissue component. Fluid-fluid levels, consistent with secondary formation of aneurysmal bone cysts, are seen in 14% of cases. GCT can mimic or be mimicked by  other benign or malignant lesions at both radiologic evaluation and histologic analysis. Rarely, GCT is associated with histologically benign lung metastases or undergoes malignant degeneration. In the past, the mainstay of treatment was surgical, primarily consisting of curettage with cement placement, with recurrence rates of 15%-25%. Recurrence is suggested by development of progressive lucency at the cement-bone interface. Other complications include pathologic fracture and postoperative infection. Denosumab, a monoclonal antibody that targets the osteoclastic activity of GCT, has produced 90% tumor necrosis in early studies, results indicative of promise as a potential adjuvant therapy.

 

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[123]

TÍTULO / TITLE:  - Straight to the heart: pulmonary vein leiomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Med. 2013 Feb;126(2):117-9. doi: 10.1016/j.amjmed.2012.11.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.amjmed.2012.11.002

AUTORES / AUTHORS:  - Patel SM; Kadakia KC; Maleszewski JJ; Marks RS

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, Mayo Clinic, Rochester, Minn.

 

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[124]

TÍTULO / TITLE:  - Use of potassium channel tetramerization domain-containing 12 as a biomarker for  diagnosis and prognosis of gastrointestinal stromal tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Jan 2. pii: S0046-8177(12)00381-4. doi: 10.1016/j.humpath.2012.10.013.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.10.013

AUTORES / AUTHORS:  - Hasegawa T; Asanuma H; Ogino J; Hirohashi Y; Shinomura Y; Iwaki H; Kikuchi H; Kondo T

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Pathology, Sapporo Medical University School of Medicine,  Chuo-ku, Sapporo 060-8543, Japan. Electronic address: hasetada@sapmed.ac.jp.

RESUMEN / SUMMARY:  - Previously, we showed that the expression of potassium channel tetramerization domain-containing 12 (KCTD12), which was discovered by a proteomics approach, is  associated with high-risk behavior of gastrointestinal stromal tumors (GISTs). Here, we examined the distribution and expression of this protein by immunostaining with a commercially available polyclonal KCTD12 antibody in GISTs  (n = 64) and other types of malignancy (n = 168) to clarify its diagnostic and clinical significance. Diffuse KCTD12 immunoreactivity was found in most GISTs (52 cases; 81%). KCTD12 expression was observed primarily in vascular endothelial cells, Purkinje cells of the cerebellum, and some neurons scattered throughout the cerebral cortex. KCTD12 was absent from not only the interstitial cells of Cajal but also interstitial cells of Cajal hyperplasia that was encountered incidentally in colon diverticulitis. KCTD12 immunostaining was also seen in malignant peripheral nerve sheath tumors (2/10 cases; 20%), synovial sarcomas (2/10; 20%), solitary fibrous tumor (1/8; 13%), angiosarcoma (1/7; 14%), and colon adenocarcinoma (1/24; 4%). In survival analyses, the 5-year recurrence-free survival rate of patients without KCTD12 expression was only 16.7% compared with  95.6% in those with KCTD12 expression (P < .0001). Ki-67 and KCTD12 were significant predictors of recurrence-free survival, and KCTD12 expression provided additional information about recurrence-free survival after accounting for Ki-67 status. Overall, KCTD12 expression was specific for GISTs from neoplastic and nonneoplastic adult tissues other than brain and served as a predictor of GIST recurrence. These findings suggest that KCTD12 is a useful and  reliable biomarker for both the diagnosis and prognosis of GIST.

 

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[125]

TÍTULO / TITLE:  - Immunohistochemical analysis for therapeutic targets and prognostic markers in low-grade endometrial stromal sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Gynecol Cancer. 2013 Jan;23(1):81-9. doi: 10.1097/IGC.0b013e3182738361.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IGC.0b013e3182738361

AUTORES / AUTHORS:  - Park JY; Kim KR; Nam JH

INSTITUCIÓN / INSTITUTION:  - Departments of *Obstetrics and Gynecology, and daggerPathology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.

RESUMEN / SUMMARY:  - OBJECTIVE: To investigate potential therapeutic targets and prognostic markers for low-grade endometrial stromal sarcoma (LGESS). MATERIALS AND METHODS: Thirty-nine patients with LGESS were included in this study. Using tissue microarrays, the immunohistochemical expression levels of 5 therapeutic targets (epidermal growth factor receptor, human epidermal growth factor 2, vascular endothelial growth factor receptor, platelet-derived growth factor receptor [PDGFR], and c-kit) and 3 proteins involved in cell proliferation (p16, p53, and  ki67) were investigated. The associations between these targets, markers, other clinicopathological factors, disease-free survival (DFS), and overall survival (OS) were analyzed. RESULTS: Epidermal growth factor receptor and human epidermal growth factor 2 were not expressed in these 39 patients. Vascular endothelial growth factor receptor, PDGFR, c-kit, p16, p53, and ki67 were expressed in 10 (25.6%), 28 (71.8%), 32 (82.1%), 18 (46.2%), 4 (10.3%), and 21 (53.8%) patients,  respectively. The expression of each marker was not significantly associated with other clinicopathological factors. On multivariate analysis, p53 and ki67 were associated with significantly poorer DFS and OS. The 5-year DFS rates were 88%, 46%, and 0% for the p53(-)/ki67(-) group (n = 18), p53(-)/ki67(+) group (n = 17), and p53(+)/ki67(+) group (n = 4) (P = 0.002), respectively; the 5-year OS rates were 100%, 71%, and 0%, respectively (P < 0.001). The time to recurrence was longer (P = 0.123), and more patients had distant recurrence in the p53(+)/ki67(+) group (P = 0.063). CONCLUSIONS: In patients with LGESS, c-kit and  PDGFR were expressed in higher portions of patients, suggesting that imatinib mesylate should be investigated as a potential targeting agent. Both p53 and ki67 demonstrated strong prognostic implications, suggesting that further evaluation using these markers is required.

 

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[126]

TÍTULO / TITLE:  - The crude extract of Corni Fructus induces apoptotic cell death through reactive  oxygen species-modulated pathways in U-2 OS human osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Environ Toxicol. 2012 Dec 12. doi: 10.1002/tox.21832.

            ●● Enlace al texto completo (gratuito o de pago) 1002/tox.21832

AUTORES / AUTHORS:  - Liao CL; Hsu SC; Yu CC; Yang JS; Tang NY; Wood WG; Lin JG; Chung JG

INSTITUCIÓN / INSTITUTION:  - Graduate Institute of Chinese Medicine, China Medical University, Taichung 404, Taiwan, Republic of China.

RESUMEN / SUMMARY:  - Crude extract of Corni Fructus (CECF) has been used in Traditional Chinese medicine for the treatment of different diseases for hundreds of years. The purpose of this study was to investigate the cytotoxic effects of CECF on U-2 OS  human osteosarcoma cells. Flow cytometry was used for measuring the percentage of viable cells, cell-cycle distribution, apoptotic cells in sub-G1 phase, reactive  oxygen species (ROS), Ca(2+) levels, and mitochondrial membrane potential (DeltaPsi(m) ). Comet assay and 4’-6-diamidino-2-phenylindole staining were used  for examining DNA damage and condensation. Western blotting was used to examine apoptosis-associated protein levels in U-2 OS cells after exposed to CECF. Immunostaining and confocal laser system microscope were used to examine protein  translocation after CECF incubation. CECF decreased the percentage of viability,  induced DNA damage and DNA condensation, G(0) /G(1) arrest, and apoptosis in U-2  OS cells. CECF-stimulated activities of caspase-8, caspase-9, and caspase-3, ROS, and Ca(2+) production, decreased DeltaPsi(m) levels of in U-2 OS cells. CECF increased protein levels of caspase-3, caspase-9, Bax, cytochrome c, GRP78, AIF,  ATF-6alpha, Fas, TRAIL, p21, p27, and p16 which were associated with cell-cycle arrest and apoptosis. These findings suggest that CECF triggers apoptosis in U-2  OS cells via ROS-modulated caspase-dependent and -independent pathways. © 2012  Wiley Periodicals, Inc. Environ Toxicol, 2012.

 

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[127]

TÍTULO / TITLE:  - Morphologic and molecular characteristics of uterine leiomyomas in hereditary leiomyomatosis and renal cancer (HLRCC) syndrome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2013 Jan;37(1):74-80. doi: 10.1097/PAS.0b013e31825ec16f.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e31825ec16f

AUTORES / AUTHORS:  - Sanz-Ortega J; Vocke C; Stratton P; Linehan WM; Merino MJ

INSTITUCIÓN / INSTITUTION:  - Translational Surgical Pathology, National Institutes of Health, Bethesda, MD 20892, USA.

RESUMEN / SUMMARY:  - Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a hereditary cancer syndrome in which affected individuals are predisposed to the development of multiple leiomyomas of the skin and uterus and aggressive forms of kidney cancer. Affected individuals harbor a germline heterozygous loss-of-function mutation of  the fumarate hydratase (FH) gene. Uterine leiomyomas are present in up to 77% of  women with this syndrome. Previous studies have shown that inactivation of the FH gene is unusual for nonsyndromic leiomyomas. Therefore, it might be possible to distinguish 2 genetic groups of smooth muscle tumors: the most common group of sporadic uterine leiomyomas without FH gene inactivation and the more unusual group of HLRCC leiomyomas in patients who harbor a germline mutation of FH, although the exact prevalence of hereditary HLRCC is unknown. We reviewed the clinical, morphologic, and genotypic features of uterine leiomyomas in 19 HLRCC patients with FH germline mutations. Patients with HLRCC syndrome were younger in age compared with those with regular leiomyomata. DNA was extracted by microdissection, and analysis of loss of heterozygosity (LOH) at 1q43 was performed. Uterine leiomyomas in HLRCC have young age of onset and are multiple,  with size ranging from 1 to 8 cm. Histopathologically, HLRCC leiomyomas frequently had increased cellularity, multinucleated cells, and atypia. All cases showed tumor nuclei with large orangeophilic nucleoli surrounded by a perinucleolar halo similar to the changes found in HLRCC. Occasional mitoses were found in 3 cases; however, the tumors did not fulfill the criteria for malignancy. Our study also showed that LOH at 1q43 was frequent in HLRCC leiomyomas (8/10 cases), similarly to what has been previously found in renal cell carcinomas from HLRCC patients. LOH is considered to be the second hit that  inactivates the FH gene. We conclude that uterine leiomyomas associated with HLRCC syndrome have characteristic morphologic features. Both, uterine leiomyomas and renal cell carcinoma share some morphologic nuclear changes and genotypic features in HLRCC patients. The specific morphologic features of the uterine leiomyomas that we describe may help in the identification of patients who may be part of the hereditary syndrome.

 

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[128]

TÍTULO / TITLE:  - Eugenol with antioxidant activity inhibits MMP-9 related to metastasis in human fibrosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Food Chem Toxicol. 2013 Jan 9. pii: S0278-6915(13)00008-2. doi: 10.1016/j.fct.2012.12.050.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.fct.2012.12.050

AUTORES / AUTHORS:  - Nam H; Kim MM

INSTITUCIÓN / INSTITUTION:  - Department of Chemistry, Dong-Eui University, Busan 614-714, Republic of Korea.

RESUMEN / SUMMARY:  - The oxidative damage of lipid, protein and DNA is known to be involved in chronic inflammation as well as metastasis. It has been highlighted for searching natural compounds without toxicity to prevent development of these diseases. Thus, it was investigated whether eugenol can inhibit matrix metalloproteinase (MMP) expression and activity as well as antioxidant effect. Eugenol was contained as a major ingredient in herbs such as clove and Magnoliae Flos. The direct scavenging effects of eugenol on DPPH radical, hydrogen peroxide, reducing power, lipid peroxidation and genomic DNA damage related to oxidative stress were evaluated in cell free system. It was observed that eugenol specifically exhibited higher inhibitory effect on hydrogen peroxide than other reactive oxygen species, and also blocked DNA oxidation and lipid peroxidation induced by hydroxyl radical. In addition, the inhibitory effects of eugenol on the activity and expression of MMP-9 activity related to metastasis were determined using gelatin zymography and western-blot. The data showed that it inhibited MMP-9 activities in PMA-stimulated HT1080 cells. Furthermore, it was found that eugenol exerts inhibitory effects on MMP-9 via inactivation of ERK. Therefore, these results suggest that eugenol could be available as an excellent agent for prevention of metastasis related to oxidative stress.

 

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[129]

TÍTULO / TITLE:  - High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Mol Pathol. 2013 Jan 4. pii: S0014-4800(12)00179-7. doi: 10.1016/j.yexmp.2012.12.004.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.yexmp.2012.12.004

AUTORES / AUTHORS:  - Hapkova I; Skarda J; Rouleau C; Thys A; Notarnicola C; Janikova M; Bernex F; Rypka M; Vanderwinden JM; Faure S; Vesely J; de Santa Barbara P

INSTITUCIÓN / INSTITUTION:  - INSERM U1046, Universite Montpellier 1, Universite Montpellier 2, Montpellier, France; Department of Pathophysiology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and are often associated with KIT or PDGFRA gene mutations. GIST cells might arise from the interstitial cells of Cajal (ICCs) or  from a mesenchymal precursor that is common to ICCs and smooth muscle cells (SMCs). Here, we analyzed the mRNA and protein expression of RNA-Binding Protein  with Multiple Splicing-2 (RBPMS2), an early marker of gastrointestinal SMC precursors, in human GISTs (n=23) by in situ hybridization, quantitative RT-PCR analysis and immunohistochemistry. The mean RBPMS2 mRNA level in GISTs was 42-fold higher than in control gastrointestinal samples (p<0.001). RBPMS2 expression was not correlated with KIT and PDGFRA expression levels, but was higher in GISTs harboring KIT mutations than in tumors with wild type KIT and PDGFRA or in GISTs with PDGFRA mutations that were characterized by the lowest RBPMS2 levels. Moreover, RBPMS2 levels were 64-fold higher in GIST samples with high risk of aggressive behavior than in adult control gastrointestinal samples and 6.2-fold higher in high risk than in low risk GIST specimens. RBPMS2 protein  level was high in 87% of the studied GISTs independently of their histological classification. Finally, by inhibiting the KIT signaling pathway in GIST882 cells, we show that RBPMS2 expression is independent of KIT activation. In conclusion, RBPMS2 is up-regulated in GISTs compared to normal adult gastrointestinal tissues, indicating that RBPMS2 might represent a new diagnostic marker for GISTs and a potential target for cancer therapy.

 

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[130]

TÍTULO / TITLE:  - (18) F-Fluorodeoxyglucose positron emission tomography/computed tomography for the detection of recurrent bone and soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer. 2012 Dec 11. doi: 10.1002/cncr.27866.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cncr.27866

AUTORES / AUTHORS:  - Al-Ibraheem A; Buck AK; Benz MR; Rudert M; Beer AJ; Mansour A; Pomykala KL; Haller B; Juenger H; Scheidhauer K; Schwaiger M; Herrmann K

INSTITUCIÓN / INSTITUTION:  - Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany;  Department of Radiology and Nuclear Medicine, King Hussein Cancer Center, Amman,  Jordan.

RESUMEN / SUMMARY:  - BACKGROUND: The clinical utility of modern hybrid imaging modalities for detecting recurrent bone or soft tissue sarcoma remains to be determined. In this report, the authors present a clinical study on the diagnostic accuracy and incremental value of integrated (18) F-fluorodeoxyglucose positron emission tomography/computed tomography ((18) F-FDG PET/CT) in patients with a history of  sarcoma who have clinically suspected disease recurrence. METHODS: Forty-three patients who had a history of bone or soft tissue sarcoma and had documented complete remission underwent (18) F-FDG PET/CT. Image analysis was performed independently for (18) F-FDG PET (n = 43) and for contrast-enhanced spiral CT (CE-CT) (n = 30) by 2 separate readers, whereas combined (18) F-FDG PET/CT (n = 43) images were analyzed in consensus by both readers. Imaging findings were rated on a 5-point scale and finally were reported as malignant, benign, or equivocal. Imaging findings were validated either by histopathology (n = 24) or by clinical follow-up (n = 19). RESULTS: (18) F-FDG PET/CT had greater sensitivity and specificity compared with CE-CT alone (94% and 92% vs 78% and 67%, respectively), resulting in significantly greater accuracy (93% vs 73%; P =  .03). (18) F-FDG PET/CT was particularly superior regarding detection of local recurrence or soft tissue lesions (sensitivity and specificity: 83% and 100% vs 50% and 100%, respectively) or bone metastases (100% and 100% vs 85% and 88%, respectively). CONCLUSIONS: (18) F-FDG PET/CT had greater diagnostic accuracy in  the detection of recurrent bone or soft tissue sarcoma compared with CE-CT alone. The detection of local recurrence was the most evident advantage of (18) F-FDG PET/CT over CE-CT. Cancer 2012. © 2012 American Cancer Society.

 

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[131]

TÍTULO / TITLE:  - Elastofibroma Dorsi: Clinicopathological Analysis of 71 Cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Thorac Cardiovasc Surg. 2013 Jan 23.

            ●● Enlace al texto completo (gratuito o de pago) 1055/s-0032-1328932

AUTORES / AUTHORS:  - Lococo F; Cesario A; Mattei F; Petrone G; Vita LM; Petracca-Ciavarella L; Margaritora S; Granone P

INSTITUCIÓN / INSTITUTION:  - Department of General Thoracic Surgery, Catholic University, Rome, Italy.

RESUMEN / SUMMARY:  - Introduction Elastofibroma dorsi (ELD) is a rare soft tissue benign tumor of the  chest wall. So far, only a few large series have been reported in the English literature and, to the best of our knowledge, radiological assessment and clinical management remain without consensus. The aim of this study is to provide, on the basis of a single-institutional, homogeneous and large experience, ample evidences to support etiological and “clinical-usefulness-grade” classification hypotheses.Materials and Methods We report observational information on 71 ELD cases and, on the basis of these, we discuss the clinical onset features, radiological and surgical characteristics, as well as pathological and immunohistochemical evidences.Results In the period between January 1994 and September 2009, 71 consecutive patients (23 male and 48  female; mean age: 60.2 years; standard deviation [SD] +/- 8.3 years) with ELD diagnosis were surgically treated at our institution. ELD was right sided in 34 patients (47.9%), left in 25 (35.2%), and bilateral in 12 (16.9%). In nine patients, ELD were diagnosed synchronously and three metachronously. Thirty-eight patients (53.5%) had no significant symptoms; 33 (46.5%) reported a clunking sensation or a localized scapular swelling during the shoulder movements. Sixty-six (93%) patients underwent surgical excision with radical intent while in five patients, a biopsy-only procedure was undertaken. Mean hospital stay was 3.0 days (SD +/- 1.2 days) with a morbidity of 10.6% (one case of major postoperative bleeding requested a surgical revision of the hemostasis). At the univariate analysis, the probability of occurrence of morbidity increases with tumor size. All operated patients are alive and well at follow-up with no sign of recurrence  and complete resolution of the symptomatology.Conclusions ELD is relatively uncommon, benign, and well controlled by radical surgery.

 

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[132]

TÍTULO / TITLE:  - Endometrial Stromal Sarcomas With Sex Cord Differentiation Are Associated With PHF1 Rearrangement.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Surg Pathol. 2012 Dec 1.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAS.0b013e318272c612

AUTORES / AUTHORS:  - D’Angelo E; Ali RH; Espinosa I; Lee CH; Huntsman DG; Gilks B; Prat J

INSTITUCIÓN / INSTITUTION:  - *Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institut of Biomedical Research (IIB Sant Pau), Autonomous University of Barcelona, Barcelona, España daggerDepartment of Pathology, University of British Columbia double daggerCentre for Translational and Applied Genomics (CTAG), British Columbia Cancer Agency, Vancouver, BC, Canada.

RESUMEN / SUMMARY:  - Endometrial stromal tumors may pose diagnostic challenges particularly when they  exhibit variant histologic appearances, involve extrauterine sites, or present as metastatic disease. In such cases, use of immunohistochemical markers and identification of specific nonrandom chromosomal rearrangements may be helpful. Over the last decade, fluorescence in situ hybridization (FISH) has been progressively incorporated as a diagnostic tool for the evaluation of endometrial stromal tumors. The purpose of this study was to review a series of these tumors  and compare the results of FISH analysis with the clinicopathologic characteristics. Three endometrial stromal nodules (ESNs), 13 endometrial stromal sarcomas (ESSs), and 7 undifferentiated endometrial sarcomas (UESs) were reviewed. Three metastases from 1 of the ESS cases were also analyzed. Nine of these tumors (1 ESN, 8 ESSs, and 1 UES) exhibited unusual histologic features, including smooth muscle (3), sex cord (7), epithelioid (1), fibromyxoid (1), and  skeletal muscle (2) differentiation. A tissue microarray was prepared, and FISH analysis was performed using break-apart and fusion probes for JAZF1, SUZ12, EPC1, and PHF1 genes. FISH was successful in 22 cases, and rearrangements involving JAZF1, SUZ12, EPC1, and PHF1 genes were detected in 10 of the 22 (45%)  uterine tumors, including 2 of the 3 ESNs and 8 of 12 ESSs. Genetic rearrangements were found neither in the 3 metastases of the ESS nor in any of the UESs. It is noteworthy that a correlation between sex cord differentiation and PHF1 rearrangement was encountered in ESSs (P=0.008). In our series, all ESSs showing sex cords had PHF1 genetic rearrangement, suggesting that such rearrangements may induce sex cord differentiation.

 

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[133]

TÍTULO / TITLE:  - Uterine Leiomyosarcoma Management, Outcome, and Associated Molecular Biomarkers:  A Single Institution’s Experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Surg Oncol. 2013 Jan 20.

            ●● Enlace al texto completo (gratuito o de pago) 1245/s10434-012-2834-0

AUTORES / AUTHORS:  - Lusby K; Savannah KB; Demicco EG; Zhang Y; Ghadimi MP; Young ED; Colombo C; Lam R; Dogan TE; Hornick JL; Lazar AJ; Hunt KK; Anderson ML; Creighton CJ; Lev D; Pollock RE

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Oncology, University of Texas, MD Anderson Cancer Center,  Houston, TX, USA.

RESUMEN / SUMMARY:  - BACKGROUND: Uterine leiomyosarcoma (ULMS) is an aggressive, rapidly progressive tumor lacking clinical and molecular predictors of outcome. METHODS: ULMS patients (n = 349) were classified by disease status at presentation to MDACC as  having intra-abdominal (n = 157) or distant metastatic disease (n = 192). Patient, tumor, treatment, and outcome variables were retrospectively retrieved.  Formalin-fixed, paraffin-embedded tumor and control tissues from these patients (n = 109) were assembled in a tissue microarray and evaluated for hormone receptors and markers of angiogenesis, cell-cycle progression and survival. Patient, tumor, and treatment variables were correlatively analyzed. RESULTS: The 5- and 10-year disease-specific survival (DSS) for the cohort was 42 and 27 %, respectively. Patients with primary intra-abdominal tumors had better outcomes than those with recurrent intraperitoneal tumors. Whites had a more favorable prognosis. In patients with intra-abdominal tumors, only mitotic count >10M/10HPF portended poorer prognosis. Patients with pulmonary metastasis had improved outcomes with “curative” metastasectomy. ULMS samples exhibited loss of ER and PR expression, overexpressed Ki-67, and altered p53, Rb, p16, cytoplasmic beta-catenin, EGFR, PDGFR-alpha, PDGFR-beta, and AXL levels. Metastatic tumors had increased VEGF, Ki-67, and survivin expression versus localized disease. Survivin and beta-catenin expression were associated with intraperitoneal recurrence; high bcl-2 expression predicted longer DSS. CONCLUSIONS: Analysis of  both clinicopathologic factors and immunohistochemical biomarkers in ULMS identified several prognostic clinical and molecular factors, suggesting that further study may lead to improved ULMS understanding and treatment.

 

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[134]

TÍTULO / TITLE:  - Comparison between taxane-based chemotherapy with conventional surgery-based therapy for cutaneous angiosarcoma: a single center experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Dermatolog Treat. 2012 Dec 5.

            ●● Enlace al texto completo (gratuito o de pago) 3109/09546634.2012.754839

AUTORES / AUTHORS:  - Fujisawa Y; Nakamura Y; Kawachi Y; Otsuka F

INSTITUCIÓN / INSTITUTION:  - Department of Dermatlogy, University of Tsukuba.

RESUMEN / SUMMARY:  - Abstract Objective To show the efficacy of taxane-based chemotherapy for the treatment of cutaneous angiosarcoma. Methods A case-control study comparing patients who received taxanes without wide local excision (group A, n=5) and patients who received conventional surgery-based therapy (group B, n=8) in one university hospital in eastern Japan. Data were collected from a total of 13 patients with cutaneous angiosarcoma treated from November 1997 through July 2009. Results Group A received taxanes: 4 patients received docetaxel, and 1 patient received paclitaxel. Radiation was used concomitantly in 2 patients. Marginal local excision was performed in 2 patients. Group B received wide local  excision followed by radiation (6 patients), docetaxel (3 patients), and interleukin-2 (2 patients). No patients in group A had local recurrence, whereas  5 out of the 8 patients in group B did (P<0.05, chi-square test). Median overall  survival was 31 months in group A, 10 months in group B. Estimated overall survival using the Kaplan-Meier method was significantly longer in group A (P<0.05, log-rank test). Conclusion In our series, taxane-based chemotherapy was  superior to conventional surgery-based therapy. Our results indicated that taxane regimens without mutilating surgery offered both local control and prevention of  metastasis, which led to prolonged survival.

 

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[135]

TÍTULO / TITLE:  - Central type of chondrosarcoma with a fulminant course—a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Coll Antropol. 2012 Sep;36(3):1037-40.

AUTORES / AUTHORS:  - Matanic D; Kukuljan M; Grgurevic E; Miletic B; Flego V; Muhvic D

INSTITUCIÓN / INSTITUTION:  - University of Rijeka, Rijeka University Hospital Center, Department of Pulmology, Rijeka, Croatia.

RESUMEN / SUMMARY:  - Primary chondrosarcoma is a rare malignant tumor. The five types of chondrosarcomas are: central, peripheral, mesenchymal, differentiated and clear cell. The classic chondrosarcomas are central (arising within a bone) or peripheral (arising from the surface of a bone). We describe a patient with central chondrosarcoma of the humerus who underwent surgery and only two weeks later presented with multiple metastases of the lung and small pulmonary tumor embolisms mimicking bilateral pneumonic infiltrates. Therefore, such a fulminant  course of central chondrosarcoma, which is not described so far, must be taken into consideration during the treatment of patients with primary chondrosarcoma.

 

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[136]

TÍTULO / TITLE:  - Spatiotemporal properties of intracellular calcium signaling in osteocytic and osteoblastic cell networks under fluid flow.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bone. 2013 Jan 14. pii: S8756-3282(13)00014-8. doi: 10.1016/j.bone.2013.01.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bone.2013.01.008

AUTORES / AUTHORS:  - Jing D; Lu XL; Luo E; Sajda P; Leong PL; Guo XE

INSTITUCIÓN / INSTITUTION:  - Department of Biomedical Engineering, Fourth Military Medical University, Xi’an,  Shaanxi 710032, China; Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

RESUMEN / SUMMARY:  - Mechanical stimuli can trigger intracellular calcium (Ca(2+)) responses in osteocytes and osteoblasts. Successful construction of bone cell networks necessitates more elaborate and systematic analysis for the spatiotemporal properties of Ca(2+) signaling in the networks. In the present study, an unsupervised algorithm based on independent component analysis (ICA) was employed to extract the Ca(2+) signals of bone cells in the network. We demonstrated that  the ICA-based technology could yield higher signal fidelity than the manual region of interest (ROI) method. Second, the spatiotemporal properties of Ca(2+)  signaling in osteocyte-like MLO-Y4 and osteoblast-like MC3T3-E1 cell networks under laminar and steady fluid flow stimulation were systematically analyzed and  compared. MLO-Y4 cells exhibited much more active Ca(2+) transients than MC3T3-E1 cells, evidenced by more Ca(2+) peaks, less time to the 1st peak and less time between the 1st and 2nd peaks. With respect to temporal properties, MLO-Y4 cells  demonstrated higher spike rate and Ca(2+) oscillating frequency. The spatial intercellular synchronous activities of Ca(2+) signaling in MLO-Y4 cell networks  were higher than those in MC3T3-E1 cell networks and also negatively correlated with the intercellular distance, revealing faster Ca(2+) wave propagation in MLO-Y4 cell networks. Our findings show that the unsupervised ICA-based technique results in more sensitive and quantitative signal extraction than traditional ROI analysis, with the potential to be widely employed in Ca(2+) signaling extraction in the cell networks. The present study also revealed a dramatic spatiotemporal difference in Ca(2+) signaling for osteocytic and osteoblastic cell networks in processing the mechanical stimulus. The higher intracellular Ca(2+) oscillatory behaviors and intercellular coordination of MLO-Y4 cells provided further evidences that osteocytes may behave as the major mechanical sensor in bone modeling and remodeling processes.

 

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[137]

TÍTULO / TITLE:  - Novel Oncologic, Surgical, and Prosthetic Treatment of High-grade Surface Osteosarcoma, Osteoblastic Mandible Type.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Maxillofac Surg. 2013 Jan 5. pii: S0278-2391(12)01608-4. doi: 10.1016/j.joms.2012.11.003.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.joms.2012.11.003

AUTORES / AUTHORS:  - Dhima M; Arce K; Moore EJ; Rieck KL; Salinas TJ

INSTITUCIÓN / INSTITUTION:  - Resident, Prosthodontics and Maxillofacial Prosthetics, Division of Prosthetic and Esthetic Dentistry, Department of Dental Specialties, Mayo Clinic, Rochester, Minnesota. Electronic address: dhima.matilda@mayo.edu.

 

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[138]

TÍTULO / TITLE:  - Is exon mutation analysis needed for adjuvant treatment of gastrointestinal stromal tumor?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastroenterol. 2013 Jan 7;19(1):144-6. doi: 10.3748/wjg.v19.i1.144.

            ●● Enlace al texto completo (gratuito o de pago) 3748/wjg.v19.i1.144

AUTORES / AUTHORS:  - Sendur MA; Ozdemir NY; Akinci MB; Uncu D; Zengin N; Aksoy S

INSTITUCIÓN / INSTITUTION:  - Mehmet Ali Nahit Sendur, Nuriye Yildirim Ozdemir, Muhammed Bulent Akinci, Dogan Uncu, Nurullah Zengin, Department of Medical Oncology, Ankara Numune Education and Research Hospital, Ankara 06100, Turkey.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs) are the most common soft tissue sarcoma of the gastrointestinal tract, resulting from an activating mutation of stem cell factor receptor (KIT), and an activating mutation of the homologous platelet-derived growth factor receptor alpha (PDGFRA) kinase. Most GISTs (90%-95%) are KIT-positive. About 5% of GISTs are truly negative for KIT expression. GISTs have been documented to resistant conventional chemotherapeutics. Due to the KIT activation that occurs in the majority of the cases, KIT inhibition is the primary treatment approach in the adjuvant treatment of metastatic GISTs. Imatinib mesylate is an oral agent that is a selective protein tyrosine kinase inhibitor of the KIT protein tyrosine kinase, and it has  demonstrated clinical benefit and objective tumor responses in most GIST patients in phase II and III trials. The presence and the type of KIT or PDGFRA mutation are predictive of response to imatinib therapy in patients with advanced and metastatic disease. Molecular analysis in phase I-II trials revealed significant  differences in objective response, progression-free survival, and overall survival between GISTs with different kinase mutations. The aim of this letter is to touch on the need for exon mutation analysis for adjuvant treatment with imatinib in GIST patients.

 

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[139]

TÍTULO / TITLE:  - Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anticancer Res. 2012 Dec;32(12):5429-35.

AUTORES / AUTHORS:  - Nishio J; Iwasaki H; Takagi S; Seo H; Aoki M; Nabeshima K; Naito M

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. jnishio@cis.fukuoka-u.ac.jp

RESUMEN / SUMMARY:  - Low-grade central osteosarcoma (LGCOS) is a very rare low-grade malignant neoplasm that is often confused with a variety of benign fibro-osseous lesions. It rarely involves the small tubular bones of the feet. We present an unusual case of LGCOS arising in the third metatarsal bone of a 16-year-old boy. The radiographic appearance was suggestive of a benign lesion. An open biopsy was performed and the initial diagnosis was fibrous dysplasia. The patient underwent  curettage of the lesion and packing of the bony defect with a synthetic bone substitute. Histologically, the curetted specimens consisted of spindle cells admixed with irregular bony trabeculae and osteoid. The spindle cells were fairly uniform with mild atypia, and cellularity varied from low to high. Immunohistochemistry showed that the tumor cells were focally-positive for cyclin-dependent kinase 4 and p53, but negative for murine double minute-2. The MIB-1 labeling index was 36.7% in the highest focus. Cytogenetic analysis exhibited the following clonal karyotypic abnormalities: 48,XY,del(6)(p11),add(8)(q24),add(12)(p11.2),+mar1,+mar-2. Spectral karyotyping demonstrated that marker chromosomes were composed mainly of chromosome 6. Metaphase-based comparative genomic hybridization analysis showed a high-level amplification of 6p12-p21 and gains of 8q21-q24, 10p15, 12q13-q15, and 16q23-q24. Based on these findings, the final diagnosis was revised to LGCOS and the patient was treated with an additional wide excision, followed by reconstruction with a free-vascularized osteocutaneous scapular flap. At 18 months of follow-up, the patient is well with no evidence of local recurrence or distant metastasis. Our case highlights the diagnostic difficulty of this tumor with limited tissue samples and the importance of immunohistochemical and molecular cytogenetic analyses in ambiguous cases.

 

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[140]

TÍTULO / TITLE:  - Eicosapentaenoic acid modulates CyA-induced proinflammatory cytokine over-expression in osteoblastic cells in vitro.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Biol Regul Homeost Agents. 2012 Oct-Dec;26(4):663-70.

AUTORES / AUTHORS:  - Musacchio E; Priante G; Valvason C; Baggio B; Sartori L

INSTITUCIÓN / INSTITUTION:  - Department of Medicine, University of Padova, Italy. estella.musacchio@unipd.it

RESUMEN / SUMMARY:  - Several adverse outcomes are reported in subjects undergoing long term Cyclosporin A (CyA) treatment. Severe osteopenia has been described in clinical and experimental reports, while beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) on bone metabolism are recognized. In the present study we investigated the effects of n-3 versus n-6 PUFAs on osteoblastic cells treated with CyA, evaluating the expression of interleukin (IL)-1&#223;, interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in two different experimental protocols and the production of IL-6, IL-1&#223;, and  tumor necrosis factor alpha (TNFalpha) in cells challenged simultaneously with CyA and eicosapentaenoic acid (EPA) for 48h. IL-1&#223; and IL-6 up-regulation, induced by CyA, was counteracted by the addition of EPA in both protocols; on the contrary, arachidonic acid (AA) magnified CyA the effects. COX-2 and iNOS levels  were not modified by CyA treatment. These in vitro results, that substantiate clinical reports of CyA-induced osteopenia, demonstrate a beneficial effect of EPA on CyA-altered cytokine profile, opening new perspectives in the non-pharmacological management of adverse outcomes in CyA-treated patients.

 

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[141]

TÍTULO / TITLE:  - An infrequent type of stroke with an unusual cause and successful therapy: basilar artery occlusion caused by a cardiac papillary fibroelastoma recanalized  12 hours after onset.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Intern Med. 2013;52(2):277-9. Epub 2013 Jan 15.

AUTORES / AUTHORS:  - Ljevak J; Mismas A; Bazina A; Matijevic V; Alvir D; Supe S; Measki SJ; Ozretic D; Poljakovic Z; Habek M

INSTITUCIÓN / INSTITUTION:  - Department of Neurology, University Hospital Center Zagreb, Croatia.

RESUMEN / SUMMARY:  - We herein report the case of a 32-year-old woman with sudden onset ataxia, limb dysmetria and somnolence. Emergency radiological findings showed bilateral cerebellar and thalamic infarctions as a result of a basilar artery occlusion. The patient was treated with intra-arterial (IA) and mechanical thrombolysis 12 hours after symptom onset and showed an excellent recovery. A diagnostic workup revealed a tumor mass on the mitral valve that was surgically removed, while a histological analysis confirmed a diagnosis of cardiac papillary fibroelastoma.

 

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[142]

TÍTULO / TITLE:  - Osteosarcoma of the hands and feet: a distinct clinico-pathological subgroup.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Virchows Arch. 2013 Jan;462(1):109-20. doi: 10.1007/s00428-012-1339-3. Epub 2012  Dec 5.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00428-012-1339-3

AUTORES / AUTHORS:  - Anninga JK; Picci P; Fiocco M; Kroon HM; Vanel D; Alberghini M; Gelderblom H; Hogendoorn PC

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Haematology and Oncology, Leiden University Medical Center, Leiden, The Netherlands.

RESUMEN / SUMMARY:  - Osteosarcomas of hands or feet are rare, and seemingly these cases differ in presentation and behavior compared to those in usual locations. The clinico-pathological presentation of patients with osteosarcomas of the hand or foot was studied and compared with published cases. Forty osteosarcomas were identified among 4,221 cases, representing 0.95 % of all osteosarcomas. Thirty of these were well documented. Mean age at diagnosis was 43 years (hands) and 36 years (feet) and male-female ratio was 1.2:1 and 2.0:1, respectively. In the hand, 62 % of the osteosarcomas presented in the metacarpals and 23 % in the phalanges, and only two cases occurred in the carpal bones. Distribution in the foot was tarsal bones 56 %, metatarsal bones 33 %, and phalanges 11 %.Of the cases in the hand 54 % were of high grade and of those in the foot 71 %. Survival of osteosarcomas of the hand or foot was 81 %. Only patients with high-grade osteosarcoma died of the disease. Histological grade was the only significant variable related to survival. High-grade osteosarcoma of the hand or feet should  be treated similar to those in conventional sites. Osteosarcomas of hands or feet are rare and in a relative high proportion are of low grade. Survival in high-grade cases is comparable to that in conventional sites.

 

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[143]

TÍTULO / TITLE:  - Orbital Myeloid Sarcoma in an Adult With Acute Myeloid Leukemia, FAB M1, and 12p- Deletion.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ophthal Plast Reconstr Surg. 2013 Jan 9.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IOP.0b013e318272d497

AUTORES / AUTHORS:  - Ple-Plakon PA; Demirci H; Cheng JX; Elner VM

INSTITUCIÓN / INSTITUTION:  - *Department of Ophthalmology and Visual Sciences and daggerDepartment of Pathology, University of Michigan, Ann Arbor, Michigan.

RESUMEN / SUMMARY:  - A 49-year-old woman with acute myeloid leukemia, FAB M1 subtype, and 12p deletion, presented with progressive right proptosis and diplopia for 1 week. Orbital CT revealed a homogenously enhancing, orbital mass engulfing the inferior rectus muscle. Histopathology revealed myeloid sarcoma for which she underwent external beam radiotherapy. Subsequently, there was no sign of local recurrence,  but she succumbed to leukemia involving the central nervous system. This is the first case, to the authors’ knowledge, of an orbital sarcoma of FAB M1 myeloblasts bearing a 12p deletion.

 

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[144]

TÍTULO / TITLE:  - Lipoma of the colon: should asymptomatic tumors be treated?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am Surg. 2013 Jan;79(1):45-6.

AUTORES / AUTHORS:  - Goya V; Ungsunan P

INSTITUCIÓN / INSTITUTION:  - Bronx Lebanon Hosptial Center/Albert Einstein School of Medicine, Bronx, New York, USA.

 

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[145]

TÍTULO / TITLE:  - Kaposi’s sarcoma in pregnancy after initiation of highly active antiretroviral therapy: a manifestation of immune reconstitution syndrome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J STD AIDS. 2012 Dec;23(12):905-6. doi: 10.1258/ijsa.2012.012141.

            ●● Enlace al texto completo (gratuito o de pago) 1258/ijsa.2012.012141

AUTORES / AUTHORS:  - Adeyemo A; Wood C; Govind A

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology.

RESUMEN / SUMMARY:  - A case of Kaposi’s sarcoma (KS) presenting as an immune reconstitution inflammatory syndrome in pregnancy with conservative management is reported. Successful outcomes for mother and baby were achieved. HIV was diagnosed at antenatal booking and highly active antiretroviral therapy commenced at 20 weeks. Multiple lymphadenopathies developed two months later. Excision biopsy of a node  confirmed KS. In the absence of advanced disease, she was managed conservatively  until delivery. The placenta showed no evidence of KS or human herpes virus 8 (HHV-8). The baby had negative HIV and HHV-8 polymerase chain reaction tests at zero, six and 12 weeks of life. Six months postpartum, the KS had regressed and HHV-8 viral load was undetectable.

 

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[146]

TÍTULO / TITLE:  - Clonal pseudo-tetraploidy in the chondromyxoid fibroma: a novel observation that  may explain the anaplastic-looking cells of this benign neoplasm.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Dev Pathol. 2013 Jan 2.

            ●● Enlace al texto completo (gratuito o de pago) 2350/12-01-1145-CR.1

AUTORES / AUTHORS:  - Liu J; Ownbey RT; Boc SF; Pezanowski DM; Patel DM; Sadri S; Vincent GA; de Chadarevian JP

INSTITUCIÓN / INSTITUTION:  - a St. Christopher’s Hospital for Children,Drexel University College of Medicine,  Department of Pathology and Laboratory Medicine.

RESUMEN / SUMMARY:  - Abstract Chondromyxoid fibroma is a rare benign tumor accounting for 1-2% of primary bone tumors. Most of the patients are young males in the second and third decades of life. Metaphyses of long bones are predominantly affected. The histology of this tumor is well established, but its genetic mechanism remains poorly characterized. To our knowledge, up to date, only 22 abnormal cytogenetic  analyses have been reported, and all contained diploidy or near-diploidy karyograms. Inv(6)(p25)(q13) and rearrangements involving regions 6p23-25, 6q12-15, and 6q23-27 constituted a recurrent observation in chondromyxoid fibromas. In this report, a pseudo-tetraploidy tumor clone with multiple numerical and structural aberrations involving 6p23 as well as other chromosomal  loci was identified in a chondromyxoid fibroma from the metaphysis of the left fibula of an 18 year-old male, which has not been reported. The finding may relate to the atypical-looking large cells seen in this benign tumor.

 

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[147]

TÍTULO / TITLE:  - Anaplastic lymphoma kinase status in rhabdomyosarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mod Pathol. 2013 Jan 11. doi: 10.1038/modpathol.2012.222.

            ●● Enlace al texto completo (gratuito o de pago) 1038/modpathol.2012.222

AUTORES / AUTHORS:  - Yoshida A; Shibata T; Wakai S; Ushiku T; Tsuta K; Fukayama M; Makimoto A; Furuta K; Tsuda H

INSTITUCIÓN / INSTITUTION:  - Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

RESUMEN / SUMMARY:  - Rhabdomyosarcoma is a rare soft tissue sarcoma that typically affects children, adolescents, and young adults. Despite treatment via a multidisciplinary approach, the prognosis of advance-stage rhabdomyosarcomas remains poor, and a new treatment strategy is needed. Anaplastic lymphoma kinase (ALK) is a receptor  tyrosine kinase that is a potential target for specific inhibitors. In this study, we investigated 116 rhabdomyosarcomas using a polymer-based ALK immunostaining method and correlated the results with clinicopathological parameters. In addition, we examined ALK status using dual-color fluorescence in  situ hybridization, PCR, and sequencing. In immunohistochemical analysis, ALK was detected in 2 (6%) of 33 embryonal rhabdomyosarcomas, 42 (69%) of 61 alveolar rhabdomyosarcomas, and 0 (0%) of 22 other subtypes, including pleomorphic, adult-spindle-cell/sclerosing, and epithelioid variants. Compared with ALK-negative alveolar rhabdomyosarcomas, ALK-positive ones are presented with metastatic spread more frequently and showed a greater extent of myogenin reactivity. Overall survival was not associated with ALK expression. FOXO1 rearrangement was significantly associated with ALK immunoreactivity. The median  ALK copy number was greater in ALK-positive tumors than in ALK-negative tumors. Most (93%) cases tested showed no selective increase in the ALK gene dosage. ALK  selective amplification and low-level selective gain were noted in one and three  cases, respectively. Further, a high-polysomy pattern (>/=4 ALK copies in >/=40%  of cells) was observed in seven cases. A significant increase in the ALK copy number was exclusive to the ALK-immunopositive cohort, but it was uncommon, accounting for only 30% of the 37 ALK-positive rhabdomyosarcomas. ALK gene rearrangement was not observed in either cohort, while an ALK somatic mutation (I1277T) was found in one ALK-negative embryonal case. Although it remains controversial whether ALK expression without gene rearrangement is therapeutically relevant, this comprehensive analysis may help future studies on  the utility of ALK-targeted therapy for patients with rhabdomyosarcoma.Modern Pathology advance online publication, 11 January 2013; doi:10.1038/modpathol.2012.222.

 

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[148]

TÍTULO / TITLE:  - Soft tissue angiofibroma: report of 2 cases of a recently described tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2012 Dec 20. pii: S0046-8177(12)00324-3. doi: 10.1016/j.humpath.2012.08.021.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.08.021

AUTORES / AUTHORS:  - Edgar MA; Lauer SR; Bridge JA; Rizzo M

INSTITUCIÓN / INSTITUTION:  - Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322. Electronic address: medgar@emory.edu.

RESUMEN / SUMMARY:  - Several soft tissue tumors are characterized by fibrous stroma with a conspicuous vascular component including cellular angiofibroma, nasopharyngeal angiofibroma,  and solitary fibrous tumor. Recently, a distinctive fibroblastic tumor composed of bland spindle cells and a complex vascular network has been characterized morphologically and shown to harbor a recurrent t(5;8) translocation with AHRR-NCOA2 gene fusion. We report our recent experience with 2 examples of this benign tumor, the diagnosis for one of which was supported by fluorescence in situ hybridization for NCOA2 rearrangement. Identification of this tumor is important to prevent misdiagnosis as a low-grade sarcoma.

 

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[149]

TÍTULO / TITLE:  - Predictors for Major Wound Complications Following Preoperative Radiotherapy and  Surgery for Soft-Tissue Sarcoma of the Extremities and Trunk: Importance of Tumor Proximity to Skin Surface.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Surg Oncol. 2012 Dec 15.

            ●● Enlace al texto completo (gratuito o de pago) 1245/s10434-012-2797-1

AUTORES / AUTHORS:  - Baldini EH; Lapidus MR; Wang Q; Manola J; Orgill DP; Pomahac B; Marcus KJ; Bertagnolli MM; Devlin PM; George S; Abraham J; Ferrone ML; Ready JE; Raut CP

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Brigham and Women’s Hospital, Boston, MA, USA,  ebaldini@partners.org.

RESUMEN / SUMMARY:  - PURPOSE: Preoperative and postoperative RT for the treatment of high-grade soft-tissue sarcoma result in similar local control and overall survival rates, but morbidities differ. Postoperative RT is associated with a higher rate of long-term fibrosis, edema, and joint stiffness. Preoperative RT is associated with higher rates of wound complications. It is important to identify predictors  for major wound complications (MWC) and to develop strategies to minimize this outcome. We reviewed our experience to determine predictors for MWC following preoperative radiotherapy (RT) and surgery for soft-tissue sarcoma. METHODS: Between January 2006 and May 2011, 103 patients with soft-tissue sarcoma of the extremities and trunk were treated with preoperative RT followed by surgery. MWCs were defined as those requiring operative or prolonged nonoperative management. Fisher’s exact test was used to compare rates. Logistic regression was used for multivariable analysis of factors potentially associated with MWCs. RESULTS: Median tumor size was 8.4 cm (range 2-25). All patients had wide or radical resections. Wound closures were primary in 70 %, a vascularized flap in 27 %, and split-thickness skin graft (STSG) in 3 %. There were 36 MWCs (35 %). Significant  predictors for MWCs on univariate analysis included diabetes, tumors >10 cm, tumors <3 mm from skin surface, and vascularized flap/STSG closure. The same four variables were significant predictors on multivariable analysis. CONCLUSIONS: MWCs following preoperative RT and surgery were common. Tumor proximity to skin surface <3 mm is a previously unreported independent predictor, and further strategies to minimize wound complications are needed.

 

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[150]

TÍTULO / TITLE:  - MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mod Pathol. 2012 Dec 7. doi: 10.1038/modpathol.2012.203.

            ●● Enlace al texto completo (gratuito o de pago) 1038/modpathol.2012.203

AUTORES / AUTHORS:  - Ravegnini G; Marino-Enriquez A; Slater J; Eilers G; Wang Y; Zhu M; Nucci MR; George S; Angelini S; Raut CP; Fletcher JA

INSTITUCIÓN / INSTITUTION:  - 1] Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Pharmacology, University of Bologna, Bologna, Italy.

RESUMEN / SUMMARY:  - Leiomyoma and leiomyosarcoma share morphological features and smooth muscle differentiation, and both arise most frequently within the uterine corpus of middle-aged women. However, they are considered biologically unrelated tumors due to their disparate clinical, cytogenetic, and molecular features. MED12, the mediator complex subunit 12 gene, has been recently implicated as an oncogene in  as many as 70% of sporadic uterine leiomyoma. In the present study, we show MED12 hotspot exon 2 mutations in extrauterine leiomyoma (3 of 19 cases) and in leiomyosarcoma (3 of 13 uterine cases). We also show that MED12 mutations are found in both primary and metastatic leiomyosarcoma. Immunoblotting studies demonstrated MED12 protein expression in 100% of leiomyomas (13) and leiomyosarcomas (20), irrespective of MED12 exon 2 mutation status or histological grade. These findings indicate that MED12 has oncogenic roles in a broad range of smooth muscle neoplasia, including tumors arising in extrauterine  locations.Modern Pathology advance online publication, 7 December 2012; doi:10.1038/modpathol.2012.203.

 

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[151]

TÍTULO / TITLE:  - Subungual exostosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cutis. 2012 Nov;90(5):241-3.

AUTORES / AUTHORS:  - Thomas JG; Henninger CA

INSTITUCIÓN / INSTITUTION:  - 1st Marine Logistics Group, Camp Pendleton, California 92055, USA. thomasjgar@yahoo.com

RESUMEN / SUMMARY:  - Subungual exostosis (SE) is a relatively uncommon benign tumor of the bone occurring in the distal phalanx of a digit. Its similarities to other dermatologic disorders involving the nail bed often can lead to misdiagnosis, which may result in inadequate or extreme treatments. We present a case of a 20-year-old man with an exquisitely tender lesion on the distal phalanx of the left fourth toe. We also review the clinical presentation, pathogenesis, histologic and radiographic findings, diagnosis, and treatment of SE.

 

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[152]

TÍTULO / TITLE:  - Comparison of characteristics of fibroids in African American and white women undergoing premenopausal hysterectomy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Fertil Steril. 2012 Nov 27. pii: S0015-0282(12)02383-7. doi: 10.1016/j.fertnstert.2012.10.039.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.fertnstert.2012.10.039

AUTORES / AUTHORS:  - Moorman PG; Leppert P; Myers ER; Wang F

INSTITUCIÓN / INSTITUTION:  - Department of Community of Family Medicine, Cancer Prevention, Detection and Control Research Program, Duke University Medical Center, Durham, North Carolina. Electronic address: patricia.moorman@duke.edu.

RESUMEN / SUMMARY:  - OBJECTIVE: To compare pathologic characteristics and epidemiologic risk factors for uterine fibroids in African American and white women undergoing hysterectomy. DESIGN: Cross-sectional analysis of women undergoing premenopausal hysterectomy.  SETTING: Two university-associated hospitals in North Carolina. PATIENT(S): African American (n = 225) and white women (n = 135) with fibroid diagnosis. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Data were obtained from an in-person interview and abstracted from operative and pathologic reports. Analysis of variance and multiple linear regression models were used to identify  characteristics associated with higher uterine weight, greater number of fibroids, and size of the largest fibroid. RESULT(S): African American women had  substantially more fibroids (9.9 vs. 4.5) with a concomitant higher mean uterine  weight (477 vs. 267 g). Although African American women had a higher prevalence of established risk factors for fibroids, such as high body mass index (BMI) and  hypertension, these factors were not associated with larger uteri or more numerous fibroids. In multiple linear regression models, the only factors statistically significantly associated with higher uterine weight, larger fibroids, and more numerous fibroids were race and nulligravidity. CONCLUSION(S): The presentation of fibroids as measured by uterine size or number of fibroids is more severe in African American women compared with white women. The differences  in presentation cannot be explained by racial differences in the prevalence of known risk factors. Additional research is needed on environmental and genetic factors that may increase the risk for fibroids.

 

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[153]

TÍTULO / TITLE:  - The etiology of uterine sarcomas: a pooled analysis of the epidemiology of endometrial cancer consortium.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Cancer. 2013 Jan 24. doi: 10.1038/bjc.2013.2.

            ●● Enlace al texto completo (gratuito o de pago) 1038/bjc.2013.2

AUTORES / AUTHORS:  - Felix AS; Cook LS; Gaudet MM; Rohan TE; Schouten LJ; Setiawan VW; Wise LA; Anderson KE; Bernstein L; De Vivo I; Friedenreich CM; Gapstur SM; Goldbohm RA; Henderson B; Horn-Ross PL; Kolonel L; Lacey JV; Liang X; Lissowska J; Magliocco A; McCullough ML; Miller AB; Olson SH; Palmer JR; Park Y; Patel AV; Prescott J; Rastogi R; Robien K; Rosenberg L; Schairer C; Ou Shu X; van den Brandt PA; Virkus RA; Wentzensen N; Xiang YB; Xu WH; Yang HP; Brinton LA

INSTITUCIÓN / INSTITUTION:  - 1] Cancer Prevention Fellowship Program, Division of Cancer Prevention, National  Cancer Institute, National Institutes of Health, Rockville, MD, USA [2] Division  of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

RESUMEN / SUMMARY:  - Background:Uterine sarcomas are characterised by early age at diagnosis, poor prognosis, and higher incidence among Black compared with White women, but their  aetiology is poorly understood. Therefore, we performed a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We also examined  risk factor associations for malignant mixed mullerian tumours (MMMTs) and endometrioid endometrial carcinomas (EECs) for comparison purposes.Methods:We pooled data on 229 uterine sarcomas, 244 MMMTs, 7623 EEC cases, and 28 829 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) for risk factors associated with uterine sarcoma, MMMT, and EEC were estimated with polytomous logistic regression. We also examined associations between epidemiological factors and histological subtypes of uterine sarcoma.Results:Significant risk factors for uterine sarcoma included obesity (body mass index (BMI)>/=30 vs BMI<25 kg m(-2) (OR: 1.73, 95% CI: 1.22-2.46), P-trend=0.008) and history of diabetes (OR: 2.33, 95% CI: 1.41-3.83). Older age at menarche was inversely associated with uterine sarcoma risk (>/=15 years vs <11 years (OR: 0.70, 95% CI: 0.34-1.44), P-trend: 0.04). BMI was significantly, but less strongly related to uterine sarcomas compared with EECs (OR: 3.03, 95% CI: 2.82-3.26) or MMMTs (OR: 2.25, 95% CI: 1.60-3.15, P-heterogeneity=0.01).Conclusion:In the largest aetiological study of uterine sarcomas, associations between menstrual, hormonal, and anthropometric risk factors and uterine sarcoma were similar to those identified for EEC. Further exploration of factors that might explain patterns of age- and race-specific incidence rates for uterine sarcoma are needed.British Journal of Cancer advance online publication, 24 January 2013; doi:10.1038/bjc.2013.2 www.bjcancer.com.

 

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[154]

TÍTULO / TITLE:  - Syndecan-2 is a key regulator of transforming growth factor beta 2/smad2-mediated adhesion in fibrosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - IUBMB Life. 2013 Feb;65(2):134-43. doi: 10.1002/iub.1112. Epub 2013 Jan 7.

            ●● Enlace al texto completo (gratuito o de pago) 1002/iub.1112

AUTORES / AUTHORS:  - Mytilinaiou M; Bano A; Nikitovic D; Berdiaki A; Voudouri K; Kalogeraki A; Karamanos NK; Tzanakakis GN

INSTITUCIÓN / INSTITUTION:  - Department of Histology-Embryology, Medical School, University of Crete, Heraklion, Greece.

RESUMEN / SUMMARY:  - Fibrosarcoma is a rare malignant tumor originating from fibroblasts. Transforming growth factor beta 2 (TGFbeta2) has been established to regulate processes correlated to fibrosarcoma tumorigenesis. In this study, we investigated the possible participation of syndecan-2 (SDC-2), a cell membrane heparan sulfate (HS) proteoglycan on these TGFbeta2 functions. Our results demonstrate that the inhibition of SDC-2 expression by short interfering RNA (siSDC2) abolished TGFbeta2-dependent HT1080 cell adhesion (P </= 0.01). In parallel, the downregulation of SDC-2 significantly inhibited TGFbeta2-induced Smad2 phosphorylation (P </= 0.01). The immunoflourescence signal of TGF receptor III as well as its protein expression was decreased in SDC-2-deficient cells. The enhancement of adhesion molecules integrin beta1 (P </= 0.01) and focal adhesion  kinase expression, induced by TGFbeta2 treatment (P </= 0.001), was markedly inhibited in SDC-2-defficient cells (P </= 0.01). Conclusively, the obtained data suggest that SDC-2 modulates TGFbeta2 transcriptional regulation via Smad signaling to facilitate fibrosarcoma cell adhesion. © 2013 IUBMB Life, 65(2)134-143, 2013.

 

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[155]

TÍTULO / TITLE:  - Clinicopathologic analysis of gallbladder carcinosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am Surg. 2013 Jan;79(1):37-9.

AUTORES / AUTHORS:  - Li BF; Li PW; Shi R; Liu ZL; Liu YF

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.

 

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[156]

TÍTULO / TITLE:  - Desmoid-type fibromatosis in the head and neck: CT and MR imaging characteristics.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neuroradiology. 2013 Jan 22.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00234-012-1037-5

AUTORES / AUTHORS:  - Rhim JH; Kim JH; Moon KC; Park SW; Sohn CH; Choi SH; Yun TJ; Chang KH

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, South Korea.

RESUMEN / SUMMARY:  - INTRODUCTION: In the head and neck region, desmoid-type fibromatosis is an uncommon tumor, and the imaging features have not been well described. The purpose of this study was to describe imaging features with their pathologic correlation of desmoid-type fibromatosis in this region. METHODS: Computed tomographic (CT) and magnetic resonance (MR) images of nine consecutive patients  (five women and four men; age range, 2-72 years; mean age, 28 years) with desmoid-type fibromatosis in the head and neck were retrospectively evaluated, focusing on lesion location, size, shape, presence of a rim of surrounding fat, CT attenuation, signal intensity, and enhancement characteristics on MR with pathologic correlation. RESULTS: Desmoid-type fibromatosis involved perivertebral space (n = 5) and carotid space (n = 1) in six adult patients. In three pediatric patients, the fibromatosis primarily involved submandibular space (n = 2) and masticator space (n = 1) with frequent invasion to the adjacent spaces (3/3). A mean greatest dimension of 5.8 cm, elongated shape (7/9), and rim of surrounding  fat (8/9) were the common features of the desmoid-type fibromatosis. Tumors often showed iso (3/7) or high attenuation (3/7) on postcontrast CT, high signal intensity (6/9) on T2-weighted image, iso signal intensity (8/9) on T1-weighted image, and strong MR enhancement (8/9). Characteristic nonenhancing low signal intensity bands (8/9) on all MR sequences were well correlated with dense collagenous stroma. CONCLUSIONS: Desmoid-type fibromatosis in the head and neck of adults frequently involves perivertebral space. Along with various common imaging features, desmoid-type fibromatosis shows characteristic nonenhancing low signal intensity bands on MR images.

 

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[157]

TÍTULO / TITLE:  - Diagnostic Usefulness of p16/CDKN2A FISH in Distinguishing Between Sarcomatoid Mesothelioma and Fibrous Pleuritis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Clin Pathol. 2013 Jan;139(1):39-46. doi: 10.1309/AJCPT94JVWIHBKRD.

            ●● Enlace al texto completo (gratuito o de pago) 1309/AJCPT94JVWIHBKRD

AUTORES / AUTHORS:  - Wu D; Hiroshima K; Matsumoto S; Nabeshima K; Yusa T; Ozaki D; Fujino M; Yamakawa H; Nakatani Y; Tada Y; Shimada H; Tagawa M

INSTITUCIÓN / INSTITUTION:  - Dept of Pathology, Tokyo Women’s Medical University Yachiyo Medical Center, 477-96 Owada-Shinden, Yachiyo, Chiba 276-8524, Japan.

RESUMEN / SUMMARY:  - The distinction between sarcomatoid mesothelioma and fibrous pleuritis is difficult based on histology, especially when the amount of tumor tissue examined via biopsy is small and immunohistochemical examination is inconclusive. We studied the usefulness of deletion of p16 with fluorescence in situ hybridization (FISH) and p16 hypermethylation with polymerase chain reaction for the diagnosis  and prognosis of malignant pleural mesothelioma (MPM). We analyzed 50 MPMs, including 22 sarcomatoid mesothelioma cases and 10 fibrous pleuritis cases. We set the cutoff value of homozygous deletion pattern as 14.4% based on FISH signaling patterns using samples of fibrous pleuritis. The percentage of homozygous deletion pattern was higher than 14.4% in 55.6% of the epithelioid mesotheliomas (10/18) and in all of the sarcomatoid mesotheliomas (22/22). Methylation of p16 was observed in 7 (20.6%) of 34 informative cases. p16 FISH analysis can be a reliable test for distinguishing between sarcomatoid mesothelioma and fibrous pleuritis and a prognostic factor for MPM.

 

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[158]

TÍTULO / TITLE:  - Modern treatment of gastric gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastroenterol. 2012 Dec 14;18(46):6720-8. doi: 10.3748/wjg.v18.i46.6720.

            ●● Enlace al texto completo (gratuito o de pago) 3748/wjg.v18.i46.6720

AUTORES / AUTHORS:  - Roggin KK; Posner MC

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Pritzker School of Medicine, University of Chicago, IL 60637, USA. kroggin@surgery.bsd.uchicago.edu

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GIST) are rare mesenchymal smooth muscle sarcomas that can arise anywhere within the gastrointestinal tract. Sporadic mutations within the tyrosine kinase receptors of the interstitial cells of Cajal have been identified as the key molecular step in GIST carcinogenesis. Although many patients are asymptomatic, the most common associated symptoms include: abdominal pain, dyspepsia, gastric outlet obstruction, and anorexia. Rarely, GIST can perforate causing life-threatening hemoperitoneum. Most are ultimately diagnosed on cross-sectional imaging studies (i.e., computed tomography and/or magnetic resonance imaging in combination with upper endoscopy. Endoscopic ultrasonographic localization of these tumors within the smooth muscle layer and  acquisition of neoplastic spindle cells harboring mutations in the c-KIT gene is  pathognomonic. Curative treatment requires a complete gross resection of the tumor. Both open and minimally invasive operations have been shown to reduce recurrence rates and improve long-term survival. While there is considerable debate over whether GIST can be benign neoplasms, we believe that all GIST have malignant potential, but vary in their propensity to recur after resection and metastasize to distant organ sites. Prognostic factors include location, size (i.e., > 5 cm), grade (> 5-10 mitoses per 50 high power fields and specific mutational events that are still being defined. Adjuvant therapy with tyrosine kinase inhibitors, such as imatinib mesylate, has been shown to reduce the risk of recurrence after one year of therapy. Treatment of locally-advanced or borderline resectable gastric GIST with neoadjuvant imatinib has been shown to induce regression in a minority of patients and stabilization in the majority of  cases. This treatment strategy potentially reduces the need for more extensive surgical resections and increases the number of patients eligible for curative therapy. The modern surgical treatment of gastric GIST combines the novel use of  targeted therapy and aggressive minimally invasive surgical procedures to provide effective treatment for this lethal, but rare gastrointestinal malignancy.

 

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[159]

TÍTULO / TITLE:  - Feasibility of fine-needle aspiration in the diagnosis of two unusual childhood jaw tumor types: prognoma and cementifying fibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Cytol. 2013;57(1):107-12. doi: 10.1159/000343890. Epub 2012 Dec 6.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000343890

AUTORES / AUTHORS:  - Barroca H; Lopes JM

INSTITUCIÓN / INSTITUTION:  - Servico de Anatomia Patologica, Centro Hospitalar Sao Joao, Porto, Portugal.

RESUMEN / SUMMARY:  - Cytology features of childhood jaw tumors are infrequently reported in the literature. Fine-needle aspiration cytology (FNAC) has been used with good results in the differential diagnosis of bone lesions, being an excellent tool for the diagnosis of metastases and in the frontline approach to primary lesions. We report 3 cases of young children aged 3 years (case 1), 5 months (case 2), and 15 years (case 3) with jaw tumors diagnosed by FNAC. In the first two cases the diagnosis was prognoma, and in the third case cementifying fibroma. Despite the clinical and imaging similarity of the 3 cases - large maxillary/mandibular tumors - their characteristic cytological features allowed a confident diagnosis, excluding other differential alternatives. In both case 1 and case 2 a dual cell  population of neuroepithelial and melanocytic cells was identified, consistent with a melanotic neuroectodermal tumor. In case 3 the presence of a bland spindle cell population as well as of several nodular dense eosinophilic, osteoid-like (cement) matrices, indicated a cementifying fibroma. All cases were resected and  confirmed by histological examination. A review of the literature, including differential diagnosis, addresses the utility of FNAC in childhood jaw tumors.

 

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[160]

TÍTULO / TITLE:  - Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Opt Lett. 2012 Dec 15;37(24):5184-6. doi: 10.1364/OL.37.005184.

AUTORES / AUTHORS:  - Wang S; Li J; Manapuram RK; Menodiado FM; Ingram DR; Twa MD; Lazar AJ; Lev DC; Pollock RE; Larin KV

RESUMEN / SUMMARY:  - We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young’s modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity  and differentiate soft-tissue tumors from normal tissues.

 

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[161]

TÍTULO / TITLE:  - miRNA expression profile in human osteosarcoma: Role of miR-1 and miR-133b in proliferation and cell cycle control.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Oncol. 2013 Feb;42(2):667-75. doi: 10.3892/ijo.2012.1717. Epub 2012 Nov 28.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ijo.2012.1717

AUTORES / AUTHORS:  - Novello C; Pazzaglia L; Cingolani C; Conti A; Quattrini I; Manara MC; Tognon M; Picci P; Benassi MS

INSTITUCIÓN / INSTITUTION:  - Laboratory of Experimental Oncology, Rizzoli Orthopaedic Institute, I-40136 Bologna, Italy.

RESUMEN / SUMMARY:  - miRNA profile deregulation affecting downstream signaling pathways activates endpoints that represent potential biomarkers for prognosis and treatment of tumor patients. In the past 20 years conventional therapy for osteosarcoma (OS) reached a survival plateau, highlighting the need for new therapeutic approaches. In this study, microarray unsupervised and supervised analysis identified, respectively, 100 and 40 differentially expressed miRNAs in OS samples with different grades of malignancy compared to normal bone. When analyzing low-grade  and high-grade OS by unsupervised analysis, 12 miRNAs were found to be differentially expressed. Realtime PCR performed on a larger series of OS confirmed a significant lower expression of miR-1, miR133b and miR-378* in tumors with respect to control, also showing lower mRNA levels in 31 high-grade OS than  in 25 low-grade and in metastatic versus nonmetastatic patients. We demonstrated  that miR-1 and miR133b were downregulated in OS cell lines compared to normal osteoblasts. Secondly, by transfection with miRNA precursor molecules, we demonstrated that the ectopic expression of miR-1 and miR-133b in U2-OS cell lines significantly reduced cell proliferation and MET protein expression and negatively regulated cell invasiveness and motility in a short-term assay. Cell cycle distribution revealed block in G1 and delay of cell cycle progression associated with increased apoptosis in miR-1- and miR133btransfected cells, respectively. Our data assessed specific miRNA profiling deregulation in OS clinical samples and suggest that the expression of miR-1 and miR-133b may control cell proliferation and cell cycle through MET protein expression modulation.

 

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[162]

TÍTULO / TITLE:  - Quantification of microvascular cerebral blood flux and late-stage tumor compartmentalization in 9L gliosarcoma using flow enhanced MRI.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - NMR Biomed. 2013 Jan 21. doi: 10.1002/nbm.2915.

            ●● Enlace al texto completo (gratuito o de pago) 1002/nbm.2915

AUTORES / AUTHORS:  - Reynaud O; Geffroy F; Ciobanu L

INSTITUCIÓN / INSTITUTION:  - CEA, DSV, I2BM, NeuroSpin, LRMN, Gif sur Yvette, France.

RESUMEN / SUMMARY:  - Measurements of tumor microvasculature are important to obtain an understanding of tumor angiogenesis and for the evaluation of therapies. In this work, we characterize the evolution of the microvascular flux at different stages of tumor growth in the 9L rat brain tumor model. The absolute quantification of cerebral blood flux is achieved with MRI at 7 T using the flow enhanced signal intensity (FENSI) method. FENSI flux maps were obtained between 5 and 14 days after glioma  cell inoculation. Based on cerebral blood flux maps, we highlighted two main stages of tumor growth, below and above 3 mm, presenting distinct flux patterns and vascular properties. No significant difference emerged from the group analysis performed on the data collected at an early developmental stage (tumor size < 3 mm) when compared with healthy tissue. At a late developmental stage (tumor size > 3 mm), we observed a significant decrease in the cerebral blood flux inside the gliosarcoma (-33%, p < 0.01) and compartmentalization of the tumor (p < 0.05). FENSI flux maps delineated a low-flux tumor core (58 +/- 17 muL/min/cm(2) ) and higher vascularized regions around the tumor periphery (85 +/- 21 muL/min/cm(2) ). Histology was performed on 11 animals to finely probe the intratumor heterogeneity and microvessel density, and the results were compared with the information derived from FENSI flux maps. The hyper- and hypoperfused tumor regions revealed with FENSI at the late tumor developmental stage correlated well with the ratios of high and low blood vessel density (R(2) = 0.41) and fractional vascular surface (R(2) = 0.67) observed with fluorescence microscopy [cluster of differentiation 31 (CD31) staining]. Copyright © 2013 John Wiley & Sons, Ltd.

 

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[163]

TÍTULO / TITLE:  - Following unenhanced MRI assessment for local recurrence after surgical resection of mesenchymal soft tissue tumors, do additional gadolinium-enhanced images change reader confidence or diagnosis?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Radiol. 2012 Dec 12. pii: S0720-048X(12)00570-0. doi: 10.1016/j.ejrad.2012.11.025.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejrad.2012.11.025

AUTORES / AUTHORS:  - Diana Afonso P; Kosinski AS; Spritzer CE

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27710, United States. Electronic address: p.diana.a@gmail.com.

RESUMEN / SUMMARY:  - PURPOSE: Evaluate if gadolinium enhanced MR imaging (GeMRI) improves confidence,  changes the final diagnosis, or improves accuracy in the assessment of musculoskeletal (MSK) tumor residual or recurrence following surgical resection.  We also assess if different experience levels change the above results. METHODS AND MATERIALS: Initially, pre-contrast images were independently reviewed by two  radiologists, one with 25 years of experience (R1) and one undergoing MSK specialty training (R2). Two questions were answered: (1) Mass present? and (2) Likelihood of malignancy? Subsequently, both pre-contrast and post-contrast images were independently reviewed. The same questions were again answered plus four others including if GeMRI changed mass characterization, better defined cystic versus solid, better defined tumor extent, or improved conspicuity. Lastly, the readers answered whether GeMRI changed confidence, and changed their  final diagnosis. Histologic diagnoses were available in 43 cases, with the remaining 44 cases based upon clinical and/or imaging follow-up. RESULTS: GeMRI definitely improved confidence in 8/7 cases, and slightly improved confidence in  20/29 cases and changed the final diagnosis in 11/8 cases for R1 and R2 respectively. Positive and negative predictive values statistically improved for  R2 (positive predictive value 36.4% versus 50%, p=0.02; negative predictive value 75.4% versus 79.1%, p=0.04) but not for R1. Reader concordance for malignancy improved with GeMRI (kappa=0.44 pre-contrast and kappa=0.71 post-contrast). CONCLUSION: GeMRI improved reader confidence, improved reader concordance and modestly improved accuracy for the less experienced reader. Where possible, GeMRI should be used in the assessment of MSK tumor residual or recurrence.

 

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[164]

TÍTULO / TITLE:  - Nasopharyngeal angiofibroma: A concise classification system and appropriate treatment options.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Otolaryngol. 2013 Jan 15. pii: S0196-0709(12)00248-7. doi: 10.1016/j.amjoto.2012.10.004.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.amjoto.2012.10.004

AUTORES / AUTHORS:  - Yi Z; Fang Z; Lin G; Lin C; Xiao W; Li Z; Cheng J; Zhou A

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology, First Affiliated Hospital of Fujian Medical University, Fuzhou, China. Electronic address: yizixiang@sina.com.

RESUMEN / SUMMARY:  - OBJECTIVES: To describe a clear and simplified classification system for juvenile nasopharyngeal angiofibroma (JNA), and to describe suitable management options. STUDY DESIGN: Retrospective medical record review. METHODS: The clinical and imaging materials of 51 cases of JNA diagnosed at our hospital between 1981 and 2011 were collected and studied. Based on our experiences, we prefer to divide JNAs into three types. Type I includes JNAs fundamentally localized to the nasal  cavity, paranasal sinus, nasopharynx, or pterygopalatine fossa. Type II is a JNA  extending into the infratemporal fossa, cheek region, or orbital cavity, with anterior and/or minimal middle cranial fossa extension but intact dura mater. Type III is a calabash-like massive tumor lobe in the middle cranial fossa. The management and prognosis for the three types of JNA were compared and evaluated.  RESULTS: Among cases of type I JNA (n=16), the entire mass was removed by the initial operation in 15 cases and by a repeat operation in 1 case. Among cases of type II JNA (n=29), the entire mass was removed by the first operation in 24 cases and by repeat operation in 5 cases. In cases of type III JNA (n=6), the huge calabash-like lobe in the middle cranial fossa could not be completely excised; 4 cases underwent radiotherapy and 2 cases were lost to follow-up. CONCLUSIONS: 1) The transnasal cavity approach with endoscopic guidance is suitable for type I JNA resection. 2) The transantral-infratemporal fossa-nasal cavity combined approach is reliable for resection of a type II JNA, which extends into the deep anterior cranial fossa and/or minimally into the middle cranial fossa, with intact dura mater. 3) The complete removal of a type III JNA  is difficult, even through a combined extracranial and intracranial approach. Radiotherapy is useful for treating the residual intracranial tumor. The successful or failed experiences of 6 typical cases prove that this revised classification system is reasonable and reliable.

 

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[165]

TÍTULO / TITLE:  - Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced  MRI using TWIST perfusion data in a uterine fibroid model.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Magn Reson Imaging. 2012 Dec 12. doi: 10.1002/jmri.23974.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jmri.23974

AUTORES / AUTHORS:  - Davenport MS; Heye T; Dale BM; Horvath JJ; Breault SR; Feuerlein S; Bashir MR; Boll DT; Merkle EM

INSTITUCIÓN / INSTITUTION:  - University of Michigan Health System, Ann Arbor, Michigan, USA. matdaven@med.umich.edu.

RESUMEN / SUMMARY:  - PURPOSE: To determine the reproducibility of TWIST-derived (Time-Resolved Angiography with Interleaved Stochastic Trajectories) quantitative dynamic contrast enhanced (DCE) MRI in a uterine fibroid model. MATERIALS AND METHODS: The institutional review board approved this retrospective study. Dynamic contrast-enhanced TWIST datasets from 15 randomly selected 1.5 Tesla pelvic MR studies were postprocessed. Five readers recorded kinetic parameters (K(trans) [volume transfer constant], v(e) [extracellular extravascular space volume], k(ep) [flux rate constant], iAUC [initial area under the gadolinium-time curve])  of the largest uterine fibroid using three region-of-interest (ROI) selection methods. Measurements were randomized and repeated three times, and measures of reproducibility were calculated. RESULTS: The intra-rater coefficients of variation (CVs, brackets indicate 95% confidence intervals) varied from 4.6% to 7.6% (K(trans) 7.6% [6.1%, 9.1%], k(ep) 7.2% [5.9%, 8.5%], v(e) 4.6% [3.8%, 5.4%], and iAUC 7.2% [6.1%, 8.3%]). v(e) was the most reproducible (P < 0.05). Inter-rater reproducibility was significantly (P < 0.05) greater for the large ROI method (range of intraclass correlation coefficients [ICCs] = 0.80-0.98 versus 0.48-0.63 [user-defined ROI] versus 0.41-0.69 [targeted ROI]). The uterine fibroid accounted for the greatest fraction of variance for the large ROI method  (range across kinetic parameters: 83-98% versus 56-69% [user-defined ROI] versus  47-74% [targeted ROI]). The reader accounted for the greatest fraction of variance for the user-defined ROI method (0.4-14.1% versus 0.1-3.0% [large ROI] versus <0.1-1.5% [targeted ROI]). CONCLUSION: Changes in TWIST-derived DCE-MRI kinetic parameters of up to 9-15% may be attributable to measurement error. Large DCE-MRI regions of interest are the most reproducible across multiple readers. J. Magn. Reson. Imaging 2012. Esta es una cita bibliográfica que va por delante de la publicación en papel. La fecha indicada en la cita provista, NO corresponde con la fecha o la cita bibliográfica de la publicación en papel. La cita bibliográfica definitiva (con el volumen y su paginación) saldrá en 1 ó 2 meses a partir de la fecha de la emisión electrónica-online. *** This is a bibliographic record ahead of the paper publication. The given date in the bibliographic record does not correspond to the date or the bibliographic citation on the paper publication. The publisher will provide the final bibliographic citation (with the volume, and pagination) within 1 or 2 months from the date the record was published online. © 2012 Wiley Periodicals, Inc.

 

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[166]

TÍTULO / TITLE:  - Ovarian fibromas and fibrothecomas: sonographic correlation with computed tomography and magnetic resonance imaging: a 5-year single-institution experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Ultrasound Med. 2013 Jan;32(1):13-8.

AUTORES / AUTHORS:  - Yen P; Khong K; Lamba R; Corwin MT; Gerscovich EO

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, University of California, Davis Medical Center, 4860 Y St, Suite 3100, Sacramento, CA 95817 USA. eugenio.gerscovich@ucdmc.ucdavis.edu.

RESUMEN / SUMMARY:  - Objectives- To evaluate imaging characteristics of ovarian fibromas and fibrothe-comas and to identify select clinical markers and imaging features to help in their diagnosis. Methods- Over a 5-year period, 18 of 29 women with histologically proven fibromas or fibrothecomas underwent sonography, computed tomography (CT), or magnetic resonance imaging (MRI). On review of the images, tumor size, solid component characteristics, and cystic components were evaluated. Age, cancer antigen 125 (CA-125), and Meig syndrome were assessed. Results- Eleven fibrothecomas and 7 fibromas were evaluated. Sonography was performed for 15 tumors, CT for 9, and MRI for 6. Mean age was 52.6 (range, 13-82) years. Mean tumor size was 8.8 (range, 2-18) cm. Seventy-two percent of the tumors were solid, and 28% had cystic components. On sonography, the solid components were isoechoic or hypoechoic compared to the uterus. On CT with contrast, 2 of 8 lesions (25%) showed enhancement. On T1-weighted MRI, 5 lesions  (83%) showed an isointense signal, and 1 (17%) showed a hyperintense signal compared to the myometrium. On T2-weighted MRI, 4 of 6 lesions (67%) were hypointense; 1 (16.5%) was isointense; and 1 (16.5%) was hyperintense. Elevated CA-125 was present in 5 of 29 patients (28%). One had Meig syndrome. Conclusions- For a cystic adnexal mass where the primary consideration is commonly an epithelial tumor, the possibility of a cystic stromal tumor should also be considered. Unlike previous studies reporting both T1 and T2 hypointensity, fibrothecomas and fibromas can also show T1 and T2 isointensity and, exceptionally, hyperintensity. Vascularity, shown by Doppler flow and MRI and CT  enhancement, is a characteristic of some fibromas and fibrothecomas. Although CA-125 is elevated in some patients, a true correlation is difficult to assess. Meig syndrome is infrequent.

 

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[167]

TÍTULO / TITLE:  - Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mod Pathol. 2012 Nov 30. doi: 10.1038/modpathol.2012.198.

            ●● Enlace al texto completo (gratuito o de pago) 1038/modpathol.2012.198

AUTORES / AUTHORS:  - Yamamoto H; Kohashi K; Fujita A; Oda Y

INSTITUCIÓN / INSTITUTION:  - Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.

RESUMEN / SUMMARY:  - MicroRNAs (miRNAs) are small, non-coding RNAs that are up- or downregulated in several types of cancer, and have an important role in the tumorigenesis and progression. To better understand the role of aberrantly expressed miRNAs and their target genes affecting the biology of gastrointestinal stromal tumor (GIST), we performed miRNA array in 19 cases of GIST, and found that several miRNAs, including miR-133b, were downregulated in high-grade GISTs. Subsequently, quantitative real-time reverse transcription-PCR revealed that fascin-1 mRNA was  upregulated in accordance with miR-133b downregulation in high-grade GIST; this result was consistent with a previous report showing that fascin-1 might be a direct target of miR-133b. We then examined the fascin-1 protein expression by immunohistochemical staining in 147 cases of GIST, and found that fascin-1 overexpression was significantly correlated with shorter disease-free survival time and several aggressive pathological factors, including tumor size, mitotic counts, risk grade, blood vessel invasion and mucosal ulceration. Our results suggest that downregulation of miR-133b and overexpression of fascin-1 may have an important role in the progression of GIST, and that fascin-1 may be a useful biomarker to predict the aggressive behavior.Modern Pathology advance online publication, 30 November 2012; doi:10.1038/modpathol.2012.198.

 

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[168]

TÍTULO / TITLE:  - Composite uterine neoplasm with embryonal rhabdomyosarcoma and primitive neuroectodermal tumor components: rhabdomyosarcoma with divergent differentiation, variant of primitive neuroectodermal tumor, or unique entity?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2012 Dec 21. pii: S0046-8177(12)00336-X. doi: 10.1016/j.humpath.2012.09.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.09.008

AUTORES / AUTHORS:  - Cate F; Bridge JA; Crispens MA; Keedy VL; Troutman A; Coffin CM; Fadare O

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

RESUMEN / SUMMARY:  - Three cases of composite uterine neoplasms comprised of primitive neuroectodermal tumor (PNET) and rhabdomyosarcoma (RMS) have previously been described, including only one wherein the rhabdomyosarcomatous component was of the embryonal subtype. Whether such composite neoplasms are a variant of RMS, a variant of PNET, or a unique entity is unknown. We report the clinicopathologic, immunohistochemical, and molecular cytogenetic findings in a case of uterine embryonal RMS with coexisting PNET that was diagnosed in a 25-year-old female. The tumor broadly involved the cervix and corpus uteri and resulted in uterine inversion. The 2 distinct components each showed classic morphologic features, including cartilage in the RMS component. The unique combination of histologic, immunohistochemical and molecular findings in composite neoplasms of this type raises a question of whether they should be classified and treated as RMS, PNET, or a unique high-grade sarcoma. A variety of clinicopathologic arguments are presented that support the notion that the current neoplasm is an embryonal rhabdomyosarcoma with divergent neuroectodermal and cartilaginous differentiation.

 

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[169]

TÍTULO / TITLE:  - Imaging findings in seven cases of congenital infantile myofibromatosis with cerebral, spinal, or head and neck involvement.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neuroradiology. 2012 Dec;54(12):1389-98. doi: 10.1007/s00234-012-1111-z. Epub 2012 Nov 16.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00234-012-1111-z

AUTORES / AUTHORS:  - Holzer-Fruehwald L; Blaser S; Rossi A; Fruehwald-Pallamar J; Thurnher MM

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Medical University Vienna, University Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

RESUMEN / SUMMARY:  - INTRODUCTION: Congenital infantile myofibromatosis (IM) is a rare mesenchymal disease, presenting with tumors in the skin, muscle, viscera, bone, and subcutaneous tissue. It can present as (a) a solitary form with subcutaneous, erythematous nodules, (b) a multicentric form with subcutaneous, muscle, and/or bony lesions, and (c) a multicentric form with visceral involvement. Cerebral or  spinal involvement in myofibromatosis has been reported rarely. METHODS: We report seven cases of histology-proven infantile myofibromatosis with brain, spine, and/or head and neck involvement. RESULTS: In three patients with multiple subcutaneous nodules, a multicentric form of IM with visceral involvement was diagnosed. In three patients, a multicentric form without visceral involvement was found. Two patients had brain involvement, and four patients had vertebral body involvement. CONCLUSION: In a newborn presenting with intraparenchymal brain lesions, epidural spinal masses, and/or vertebra plana or lytic lesions of the calvarium and spine, infantile myofibromatosis should be considered as a possible differential diagnosis. The presence of subcutaneous or muscular nodules facilitates the diagnosis.

 

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[170]

TÍTULO / TITLE:  - Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Histopathology. 2012 Oct 8. doi: 10.1111/his.12039.

            ●● Enlace al texto completo (gratuito o de pago) 1111/his.12039

AUTORES / AUTHORS:  - Matsubara A; Sekine S; Yoshida M; Yoshida A; Taniguchi H; Kushima R; Tsuda H; Kanai Y

INSTITUCIÓN / INSTITUTION:  - Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

RESUMEN / SUMMARY:  - AIMS: To determine the prevalence of MED12 mutations in smooth muscle tumours of  different organs. METHODS AND RESULTS: A total of 142 smooth muscle tumours of the uterus, gastrointestinal tract, retroperitoneum and soft tissue were analysed for MED12 mutations using Sanger sequencing. Among the uterine tumours that were  examined, MED12 mutations were identified in 36 of 45 conventional leiomyomas (80%), two of six cellular leiomyomas (33%), one of four bizarre leiomyomas (25%), none of four lipoleiomyomas (0%), and two of 12 leiomyosarcomas (17%). The two MED12-mutated leiomyosarcomas were associated with benign leiomyomatous components that also harboured MED12 mutations identical to those in the respective leiomyosarcomatous components. None of the extrauterine smooth muscle  tumours, including the leiomyomas, leiomyosarcomas, and angioleiomyomas, had MED12 mutations. CONCLUSIONS: Among uterine smooth muscle tumours, MED12 mutations are frequently present in conventional leiomyomas, but are significantly less common in histological variants of leiomyoma and leiomyosarcoma. In contrast to uterine lesions, none of the extrauterine smooth muscle tumours had MED12 mutations.

 

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[171]

TÍTULO / TITLE:  - Sarcomatoid Carcinoma of the Urinary Bladder.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Urol. 2013 Jan 12. pii: S0022-5347(13)00047-5. doi: 10.1016/j.juro.2013.01.021.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.juro.2013.01.021

AUTORES / AUTHORS:  - Humphrey PA

INSTITUCIÓN / INSTITUTION:  - Department of Pathology and ImmunologyWashington University School of MedicineSt. Louis, Missouri.

 

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[172]

TÍTULO / TITLE:  - Bladder Leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Urol. 2013 Jan 18. pii: S0022-5347(13)00069-4. doi: 10.1016/j.juro.2013.01.038.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.juro.2013.01.038

AUTORES / AUTHORS:  - Goel R; Thupili CR

INSTITUCIÓN / INSTITUTION:  - Cleveland Clinic Cleveland, Ohio.

 

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[173]

TÍTULO / TITLE:  - Retroperitoneal Liposarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Urol. 2012 Nov 28. pii: S0022-5347(12)05633-9. doi: 10.1016/j.juro.2012.11.122.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.juro.2012.11.122

AUTORES / AUTHORS:  - Chang IY; Herts BR

INSTITUCIÓN / INSTITUTION:  - Imaging Institute, Cleveland Clinic, Cleveland, Ohio.

 

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[174]

TÍTULO / TITLE:  - Desmoid fibromatosis in children and adolescents: A conservative approach to management.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Surg. 2013 Jan;48(1):62-6. doi: 10.1016/j.jpedsurg.2012.10.017.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpedsurg.2012.10.017

AUTORES / AUTHORS:  - Honeyman JN; Theilen TM; Knowles MA; McGlynn MM; Hameed M; Meyers P; Crago AM; La Quaglia MP

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

RESUMEN / SUMMARY:  - PURPOSE: Desmoid fibromatosis is associated with frequent recurrence and significant morbidity, but no metastases. To examine the impact of initial non-operative management on event-free survival (EFS) in children, we reviewed our institutional experience with this tumor. METHODS: We retrospectively reviewed our institutional database for pediatric cases of desmoid fibromatosis treated between 1970 and 2010. Survival was analyzed using the Kaplan-Meier method and log-rank test. RESULTS: Ninety-three patients were identified, with a  median follow-up of 6years. Median age at diagnosis was 16years. Forty-seven patients presented with primary tumors, and forty-six had recurrent or progressing disease. Five-year OS was 100%, and 5-year EFS was 31.8%, with a median time to event of 1.48years. There was no significant difference in 5-year  EFS between patients who were managed expectantly and those who initially received treatment (21% versus 34%, P=.09). Sex, race, history of trauma, or familial adenomatous polyposis, multifocality, tumor size, tumor location, and resection status did not correlate with EFS. CONCLUSION: Our findings support a conservative initial approach in the management of desmoid fibromatosis. In patients at risk for morbid procedures, upfront resection should be reserved for  select tumors that demonstrate aggressive growth or cause serious symptoms.

 

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[175]

TÍTULO / TITLE:  - The Proteasome Inhibitor Bortezomib Stimulates Osteoblastic Differentiation of Human Osteoblast Precursors via Upregulation of Vitamin D Receptor Signalling.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Haematol. 2013 Jan 11. doi: 10.1111/ejh.12069.

            ●● Enlace al texto completo (gratuito o de pago) 1111/ejh.12069

AUTORES / AUTHORS:  - Kaiser MF; Heider U; Mieth M; Zang C; von Metzler I; Sezer O

INSTITUCIÓN / INSTITUTION:  - Department of Haematology and Oncology, Charite Universitatsmedizin Berlin, Germany.

RESUMEN / SUMMARY:  - Interactions of myeloma cells with the bone marrow microenvironment lead to enhanced osteoclast recruitment and impaired osteoblast activity. Recent evidence revealed that the proteasome inhibitor bortezomib stimulates osteoblast differentiation, but the mechanisms are not fully elucidated. We hypothesized that bortezomib could influence osteoblastic differentiation via alteration of vitamin D signalling by blocking the proteasomal degradation of the vitamin D receptor (VDR). This is of clinical importance, since a high rate of vitamin D deficiency was reported in myeloma patients. We performed cocultures of primary human mesenchymal stem cells (hMSC) and human osteoblasts (hOB) with myeloma cells, which resulted in an inhibition of the vitamin D dependent differentiation of osteoblast precursors. Treatment with bortezomib led to a moderate increase of osteoblastic differentiation markers in hMSC and hOB. Importantly, this effect could be strikingly increased when vitamin D was added. Bortezomib led to enhanced nuclear VDR protein levels in hMSC. Primary hMSC transfected with a VDR  luciferase reporter construct showed a strong increase in VDR signalling with bortezomib. In summary, stimulation of VDR signalling is a mechanism for the bortezomib-induced stimulation of osteoblastic differentiation. The data suggest  that supplementation of vitamin D in myeloma patients treated with bortezomib is  crucial for optimal bone formation. © 2013 John Wiley & Sons A/S.

 

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[176]

TÍTULO / TITLE:  - Alteration of Histone H3 Lysine 4 Trimethylation on Putative Lytic Gene Promoters by Human Set1 Complex during Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Intervirology. 2013 Jan 9.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000343749

AUTORES / AUTHORS:  - Jong JE; Cha S; Jang JH; Seo T

INSTITUCIÓN / INSTITUTION:  - Department of Life Science, Dongguk University-Seoul, Seoul, South Korea.

RESUMEN / SUMMARY:  - Objective: Histone H3 lysine 4 is trimethylated by the human Set1 complex, which  regulates the activation of gene expression. The aim of this study was to identify whether the levels of histone H3 lysine 4 trimethylation (H3K4me3) and the recruitment of human Set1 complex at the promoter regions of lytic genes quantitatively change during reactivation from latent to lytic infection of Kaposi’s sarcoma-association herpesvirus (KSHV). Methods: During KSHV reactivation, global changes of H3K4 methylation in KSHV-infected cells were analyzed by Western blot. The relative levels of association between proteins and promoter regions were determined by chromatin immunoprecipitation assay and quantitative real-time PCR using specific antibodies and primer sets. Results: Our results showed that KSHV reactivation does not alter the overall cellular levels of H3K4 methylation. We observed that the switch from latency to lytic cycle leads to upregulation of H3K4me3 at the active lytic genes. We also found that the recruitment of RNA pol II and subunits of human Set1 complex were enriched at the same regions in response to KSHV reactivation. Conclusion: These  results demonstrate that the increase of H3K4me3 by human Set1 complex is involved in activation of lytic genes during the lytic infection of KSHV.

 

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[177]

TÍTULO / TITLE:  - Erratum to: Two-year adjuvant imatinib mesylate after complete resection of localized, high-risk GIST with KIT exon 11 mutation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Chemother Pharmacol. 2013 Feb;71(2):551-2. doi: 10.1007/s00280-012-2053-1.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00280-012-2053-1

AUTORES / AUTHORS:  - Kang YK; Kang BW; Im SA; Lee JL; Park SR; Kang WK; Chang HM; Kim TW; Oh DY; Jung KH; Ryu MH

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea, ykkang@amc.seoul.kr.

 

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[178]

TÍTULO / TITLE:  - Dermatofibrosarcoma protuberans arising at a Rho(D) immune globulin injection site.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cutis. 2012 Nov;90(5):233-4.

AUTORES / AUTHORS:  - Hirano SA; Torosky CM

INSTITUCIÓN / INSTITUTION:  - Eastern Virginia Medical School, Norfolk, USA. shirano@gmail.com

RESUMEN / SUMMARY:  - Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor arising in the dermis. It is notorious for high rates of local recurrence despite its low metastatic potential. Although the etiology is unknown, DFSP often is considered  to arise within scars and at sites of prior vaccination or trauma. Clinically, DFSP can be highly variable and mimic other soft tissue proliferations. We present a case of recurrent DFSP arising at the site of a Rho(D) immune globulin  (Rhlg) injection that was administered 7 years prior. We also discuss the diagnostic challenges of DFSP as well as the indolent and locally recurrent nature of the tumor. This case serves to remind dermatologists of the highly variable clinical appearance of DFSP as well as to warn against presumptive diagnoses of lesions that mimic keloids and hypertrophic scars.

 

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[179]

TÍTULO / TITLE:  - Primary intracranial soft tissue sarcoma in children and adolescents: a cooperative analysis of the European CWS and HIT study groups.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurooncol. 2012 Dec 11.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11060-012-1020-3

AUTORES / AUTHORS:  - Benesch M; von Bueren AO; Dantonello T; von Hoff K; Pietsch T; Leuschner I; Claviez A; Bierbach U; Kropshofer G; Korinthenberg R; Graf N; Suttorp M; Kortmann RD; Friedrich C; von der Weid N; Kaatsch P; Klingebiel T; Koscielniak E; Rutkowski S

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 38, 8036, Graz, Austria, martin.benesch@klinikum-graz.at.

RESUMEN / SUMMARY:  - Purely intracranial soft tissue sarcomas (ISTS) are very rare among children. A retrospective database analysis of the Cooperative Weichteilsarkom Studiengruppe  (CWS) and brain tumor (HIT) registries was conducted to describe treatment and long-term outcome of children and adolescents with ISTS. Nineteen patients from Germany, Austria and Switzerland were reported between 1988 and 2009. Median age  at diagnosis was 9.7 years (range, 0.5-17.8). Central pathological review was performed in 17 patients. Eleven patients underwent a total and five a subtotal tumor resection. A biopsy was done in one patient. In two patients no data concerning extent of initial resection was available. Radiotherapy was performed  in 15 patients (first-line, n = 11; following progression, n = 4). All but one patient received chemotherapy (first-line, n = 7, following progression, n = 5; first-line and following progression, n = 6). With a median follow-up of 5.8 years (range, 0.6-19.8) ten patients were alive in either first or second complete remission. Seven patients died due to relapse or progression and two were alive with progressive disease. Estimated progression-free and overall survival at 5 years were 47 % (+/-12 %) and 74 % (+/-10 %), respectively. About 50 % of patients with ISTS remain relapse-free after 5 years. Multimodality treatment including complete tumor resection and radio-/chemotherapy is required  to achieve sustained tumor control in patients with ISTS. Early initiation of postoperative non-surgical treatment seems to be important to prevent recurrence. Due to the intracranial localization local therapy should follow the recommendations used in brain tumors rather than in soft tissue sarcomas, whereas chemotherapy should be guided by histological subtype.

 

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[180]

TÍTULO / TITLE:  - Primary angiosarcoma of the aorta, great vessels, and the heart.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Vasc Surg. 2013 Jan 8. pii: S0741-5214(12)02010-1. doi: 10.1016/j.jvs.2012.09.023.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jvs.2012.09.023

AUTORES / AUTHORS:  - Fatima J; Duncan AA; Maleszewski JJ; Kalra M; Oderich GS; Gloviczki P; Suri RM; Bower TC

INSTITUCIÓN / INSTITUTION:  - Division of Vascular and Endovascular Surgery, Mayo Clinic.

RESUMEN / SUMMARY:  - OBJECTIVE: Primary angiosarcomas originating from the heart, aorta, or great vessels are extremely rare and hence poorly understood. We reviewed our experience to identify a preferred diagnostic and treatment strategy and evaluate the role of adjunctive therapy. METHODS: We reviewed the clinical data of all patients diagnosed with primary angiosarcoma of the heart, aorta, and great vessels from 1985 to 2011, including presentation, diagnosis, management, and outcomes. RESULTS: Thirteen patients (five males and eight females; mean age, 54  +/- 4 years) had primary angiosarcoma arising from the aorta (n = 7), heart (n =  3), pericardium (n = 2), and pulmonary artery (n = 1). Patients with aortic tumors most commonly presented with lower extremity claudication (n = 2), renovascular hypertension (n = 3), abdominal pain (n = 5), and weight loss (n = 4). Patients with cardiac and pericardial tumors presented with dyspnea (n = 5) due to pleural effusion or cardiac tamponade. All 13 patients underwent computed  tomographic scan, which demonstrated irregular, lobulated mass/thrombus with peripheral enhancement, and eight patients underwent diagnostic echocardiography. Metastatic disease was present in 10 patients. The most common site was the lungs (n = 6). All except one patient exhibited high-grade morphology histopathologically. Nine patients were treated surgically: resection with aortic reconstruction (n = 5), thromboendarterectomy (n = 2), pericardiectomy/atrial septal resection with patch reconstruction (n = 2), and just biopsy (n = 1). Adjunctive treatment included chemotherapy (n = 6) and radiation (n = 4). Median  survival was 8 months (range, 1-75 months). Patients treated with all three treatment modalities had longer survival than did patients treated with a single  modality (P = .013). Patients treated with chemotherapy had a more favorable survival than did those without chemotherapy (P = .048). CONCLUSIONS: Primary angiosarcoma of the heart and great vessels is rare but is a harbinger of poor prognosis. Pathologic examination is necessary to confirm the diagnosis. Combined therapy with surgical resection and chemoradiotherapy offers patients the best survival.

 

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[181]

TÍTULO / TITLE:  - Oncogene alterations in endometrial carcinosarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2012 Nov 28. pii: S0046-8177(12)00310-3. doi: 10.1016/j.humpath.2012.07.027.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.07.027

AUTORES / AUTHORS:  - Biscuola M; Van de Vijver K; Castilla MA; Romero-Perez L; Lopez-Garcia MA; Diaz-Martin J; Matias-Guiu X; Oliva E; Calvo JP

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, 41013 Sevilla, España.

RESUMEN / SUMMARY:  - Endometrial carcinosarcomas are aggressive neoplasias composed of high-grade carcinomatous and sarcomatous elements. The pathogenesis and specific genetic alterations underlying these tumors are still not well known. We analyzed alterations in oncogenes involved in the pathogenesis of endometrial carcinomas that might represent predictive markers for specific therapies. Immunohistochemistry for HER2 (tyrosine kinase-type cell surface receptor HER2) and c-KIT (tyrosine-protein kinase Kit) and fluorescence in situ hybridization for EGFR (epidermal growth factor receptor) and ALK (anaplastic lymphoma receptor tyrosine kinase) were carried out for 76 endometrial carcinosarcoma samples on sequential tissue microarray sections. Analysis of 238 mutations across 19 common oncogenes was performed on 34 samples using the Sequenom OncoCarta Panel (Sequenom, Hamburg, Germany). We observed EGFR, HER2, and c-KIT expression in 71%, 1.5%, and 2.7% of tumors, respectively. EGFR amplification was detected in 11 of 76 endometrial carcinosarcomas (14.5%). Four samples showed both amplification and aneuploidy (5.2%). ALK amplification together with chromosome 2 polysomy was found in 1.3% of endometrial carcinosarcomas. In total, 23 mutations in 9 different oncogenes were detected in 15 (44.1%) of 34 endometrial carcinosarcomas. Five endometrial carcinosarcomas (14.7%) had 2 or more mutations. Eleven tumors (32.3%) had mutations affecting the PI3K (phosphoinositide-3-kinase)/AKT (v-akt murine thymoma viral oncogene homolog 1) (6 mutations in PIK3CA (PI3K catalytic alpha polypeptide) and 1 in AKT) and/or RAS/BRAF (serine/threonine-protein kinase B-raf) pathway (3 KRAS [kirsten RAS oncogene homolog], 2 NRAS [neuroblastoma RAS viral oncogene homolog], and 1 BRAF). Mutations in PDGFRA (platelet-derived growth factor receptor, alpha polypeptide) and/or KIT were found in 5 endometrial carcinosarcomas (14.7%). Finally, we found mutations in MET (met proto-oncogene [hepatocyte growth factor  receptor]) in 2 tumors (5.9%) and in EGFR in one (2.9%). Our study evidences mutations in oncogenes in endometrial carcinosarcomas that are targets or modulators of response to specific therapies in other human cancers, with PI3K/AKT being the most frequently altered pathway.

 

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[182]

TÍTULO / TITLE:  - Biomarkers in uterine leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Fertil Steril. 2012 Nov 29. pii: S0015-0282(12)02392-8. doi: 10.1016/j.fertnstert.2012.10.048.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.fertnstert.2012.10.048

AUTORES / AUTHORS:  - Levy G; Hill MJ; Plowden TC; Catherino WH; Armstrong AY

INSTITUCIÓN / INSTITUTION:  - Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National  Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

RESUMEN / SUMMARY:  - Biomarkers are biologic compounds that are easily accessible and reflect normal physiology or pathology. They are useful in a variety of clinical situations that involve detection of subclinical disease, risk stratification, preoperative planning, and monitoring treatment. A useful intervention needs to exist for a biomarker to be an effective tool. Many compounds have been investigated as potential biomarkers for the diagnosis and surveillance of uterine leiomyomas. Most of these compounds demonstrate subtle differences among patients when leiomyomas are compared with controls. The compounds investigated lack the diagnostic accuracy necessary to add any benefit to the current available modalities used to diagnose and monitor uterine leiomyomas.

 

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[183]

TÍTULO / TITLE:  - A unique pattern of INI1 immunohistochemistry distinguishes synovial sarcoma from its histologic mimics.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2012 Dec 13. pii: S0046-8177(12)00315-2. doi: 10.1016/j.humpath.2012.08.014.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.08.014

AUTORES / AUTHORS:  - Arnold MA; Arnold CA; Li G; Chae U; El-Etriby R; Lee CC; Tsokos M

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Nationwide Children’s Hospital, Columbus, OH 43205. Electronic address: Michael.Arnold@Nationwidechildrens.org.

RESUMEN / SUMMARY:  - The absence of INI1 (SMARCB1, hSNF5, BAF47) immunohistochemical reactivity is a central feature of malignant rhabdoid tumor, renal medullary carcinoma, and epithelioid sarcoma. We characterized INI1 immunoreactivity in synovial sarcoma (49 cases) in comparison with its closest histologic mimics (68 cases). We observed a unique pattern of decreased INI1 immunoreactivity with a high specificity (100%) and sensitivity (86%) for synovial sarcoma and particular sensitivity for poorly differentiated subtypes of synovial sarcoma (94%; 16/17 cases). Decreased INI1 immunoreactivity was not seen in any of the other lesions  we examined, including 14 cases of Ewing sarcoma and 22 cases of malignant peripheral nerve sheath tumor. Furthermore, decreased INI1 immunoreactivity is distinct from the complete absence of INI1 immunoreactivity seen in malignant rhabdoid tumor or other INI1-negative neoplasms. We propose that this distinct INI1 immunohistochemical pattern serves as a useful diagnostic tool to provide preliminary results before molecular test results are available, especially in cases of poorly differentiated synovial sarcoma and in cases where limited material precludes confirmatory molecular studies. Awareness of this unique pattern is critical to avoid misinterpreting decreased INI1 immunoreactivity as a complete absence of INI1 and, consequently, misdiagnosing synovial sarcoma as an  INI1-negative neoplasm.

 

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[184]

TÍTULO / TITLE:  - Myxofibrosarcoma: prevalence and diagnostic value of the “tail sign” on magnetic  resonance imaging.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Skeletal Radiol. 2013 Jan 15.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00256-012-1563-6

AUTORES / AUTHORS:  - Lefkowitz RA; Landa J; Hwang S; Zabor EC; Moskowitz CS; Agaram NP; Panicek DM

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA, lefkowir@mskcc.org.

RESUMEN / SUMMARY:  - OBJECTIVE: Myxofibrosarcoma frequently shows curvilinear extensions of high T2 signal that also enhance on magnetic resonance imaging; these “tails” represent fascial extension of tumor at histopathological examination. This study was performed to determine whether the tail sign is helpful in distinguishing myxofibrosarcoma from other myxoid-containing neoplasms. MATERIALS AND METHODS: The study group consisted of 44 patients with pathologically proven myxofibrosarcoma; the control group consisted of 52 patients with a variety of other myxoid-predominant tumors. Three musculoskeletal radiologists independently evaluated T2-weighted (and/or short-tau inversion recovery) and post-contrast MR  images for the presence of one or more enhancing, high-signal intensity, curvilinear projections from the primary mass. Sensitivity and specificity for the diagnosis of myxofibrosarcoma were calculated for each reader. Interobserver  variability was assessed with kappa statistic and percentage agreement. RESULTS:  A tail sign was deemed present in 28, 30, and 34 cases of myxofibrosarcoma and in 11, 9, and 5 of the controls for the three readers respectively, yielding a sensitivity of 64-77 % and a specificity of 79-90 %. The interobserver agreement  was moderate-to-substantial (kappa = 0.626). CONCLUSION: The tail sign at MRI is  a moderately specific and sensitive sign for the diagnosis of myxofibrosarcoma relative to other myxoid-containing tumors.

 

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[185]

TÍTULO / TITLE:  - Mast Cell Sarcoma in an Infant: A Case Report and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Hematol Oncol. 2012 Nov 30.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MPH.0b013e318279e392

AUTORES / AUTHORS:  - Bautista-Quach MA; Booth CL; Kheradpour A; Zuppan CW; Rowsell EH; Weiss L; Wang J

INSTITUCIÓN / INSTITUTION:  - Departments of *Pathology and Laboratory Medicine daggerPediatric Hematology and  Oncology, Loma Linda University Medical Center, Loma Linda, CA double daggerClarient Inc., Aliso Viejo, CA.

RESUMEN / SUMMARY:  - Mast cell diseases comprise a spectrum of disorders including cutaneous mastocytosis, indolent or aggressive systemic variants including leukemia, and unifocal tumor formations such as benign extracutaneous mastocytoma or aggressive mast cell sarcoma (MCS). Many mast cell diseases are associated with aberrancy of c-KIT proto-oncogene resulting in tyrosine kinase activity, typically exhibiting  point mutation in codon 816. MCS is an exceedingly rare clinicopathologic entity  characterized by a unifocal accumulation of neoplastic mast cells that grow in a  locally destructive manner. We report a case in a 2-year-old boy who was initially diagnosed at 8 months of age with atypical cutaneous mastocytoma of the right ear with subsequent aggressive, destructive growth pattern; features that were most consistent with MCS. So far, MCS has been documented in the literature  in at least 6 human cases. To the best of our knowledge, our case represents the  first MCS in an infant. Thorough multimodal approach with strict follow-up is relevant in appropriately diagnosing this rare entity, particularly in differentiating this lesion from other neoplasms that are more likely to occur in infancy.

 

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[186]

TÍTULO / TITLE:  - A case of atypical fibroxanthoma of subungual type: ultrasound and magnetic resonance imaging findings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Jan-Feb;37(1):155-8. doi: 10.1016/j.clinimag.2012.01.035. Epub 2012 Jun 8.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.01.035

AUTORES / AUTHORS:  - Lee S; Joo KB; Park CK; Kim TS; Bae J

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Hanyang University Hospital, Seoul 133-792, Korea.

RESUMEN / SUMMARY:  - Subungual atypical fibroxanthoma is a rare mesenchymal skin tumor of intermediate malignancy. It classically presents as a relatively nondescript, erythematous nodule; it may ulcerate and bleed, but pain and pruritus are uncommon. In the differential diagnoses of subungual tumors, glomus tumor, soft tissue chondroma,  keratoacanthoma, hemangioma, lobular capillary hemangioma, epidermal and mucoid cysts, squamous cell carcinoma, and malignant melanoma have been suggested. But atypical fibroxanthoma has not been included in the differential diagnoses. We report a case that occurred in a 56-year-old man with subungual atypical fibroxanthoma mimicking malignant soft tissue tumor in the right fifth toe.

 

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[187]

TÍTULO / TITLE:  - Frontal Headache Induced by Osteoma of Frontal Recess.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Headache. 2012 Dec 20. doi: 10.1111/head.12029.

            ●● Enlace al texto completo (gratuito o de pago) 1111/head.12029

AUTORES / AUTHORS:  - Kim KS

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, South Korea.

RESUMEN / SUMMARY:  - We reported a case of osteoma involving the frontal recess, which presented as frontal headache and reviewed literatures. Also, this case highlights that sinunasal osteomas can cause pain by local mass effects, referred pain, or prostaglandin E2-mediated mechanisms.

 

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[188]

TÍTULO / TITLE:  - Lumbar vertebral chordoma: diffusion-weighted imaging findings are helpful to narrow the differential diagnosis. A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Jan-Feb;37(1):176-9. doi: 10.1016/j.clinimag.2012.02.022. Epub 2012 Jun 8.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.02.022

AUTORES / AUTHORS:  - Sartoretti-Schefer S; Oberle J; Binkert C; Pfofe D; Gutzeit A

INSTITUCIÓN / INSTITUTION:  - Institute of Radiology, Kantonsspital Winterthur, Brauerstrasse 15, 8401 Winterthur, Switzerland. sabine.sartoretti@ksw.ch

RESUMEN / SUMMARY:  - Solitary vertebral chordoma presents as an intra- and extraosseous tumour with typical bright signal on T2-weighted images and moderate inhomogeneous enhancement on T1 postcontrast images. The diffusion weighted imaging (DWI) characteristics of this histologically proven third lumbar vertebra chordoma are  reported for the first time. The DWI hyperintensity with increased apparent diffusion coefficient (ADC) values strongly supports the preoperative diagnosis of a vertebral chordoma, allows for careful preoperative planning of the surgical procedure, and helps to narrow the differential diagnosis.

 

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[189]

TÍTULO / TITLE:  - Heat Shock Protein 90B1 Plays an Oncogenic Role and is a Target of microRNA-223 in Human Osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cell Physiol Biochem. 2012;30(6):1481-90. doi: 10.1159/000343336. Epub 2012 Dec 7.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000343336

AUTORES / AUTHORS:  - Li G; Cai M; Fu D; Chen K; Sun M; Cai Z; Cheng B

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Rd, Shanghai 200072, China.

RESUMEN / SUMMARY:  - Background/Aims: Over the past decade, heat shock protein 90 (Hsp90) has emerged  as a potential therapeutic target for cancer. However, the molecular mechanisms of down-regulation Hsp90 expression in osteosarcoma are incompletely understood.  To develop potential therapy targeting Heat shock protein 90B1 (Hsp90B1), we studied the roles of miR- 223 in the proliferation and apoptosis of human osteosarcoma. Methods: pcDNA3.1(+)- miR-223 plasmid vectors were constructed and  transfected into MG63 cells. Co-transfection of miR-223 expression vector with pMIR-Hsp90B1 (The recombined vector of pMIR-GLOTM luciferase vector containing Hsp90B1-3’UTR) led to the reduced activity of luciferase in a dual-luciferase reporter gene assay, suggesting that Hsp90B1 is a target gene of miR-223. Expression of HSP90B1 was detected by RT-PCR and western blotting analysis. Cell  proliferation was determined using the MTT assay. Cell-cycle distribution and apoptosis were examined by flow cytometry. PI3K, p-Akt, Akt, mTOR, Bcl-2 and Bid  were also detected by western blotting analysis. After a mouse xenograft model of human MG63 tumors was constructed, tumor growth, microvessel density and proliferation in each group was determined. Results: The pcDNA3.1(+)-miR-223 vector efficiently suppressed the expression of HSP90B1, while silencing miR-223  increased expression of Hsp90B1. Furthermore, overexpression of miR-223 results in significant inhibition of cell growth on culture plates. Moreover, cancer cells showed significant G0/G1 arrest and increased apoptosis due to gene silencing. Protein levels of PI3k, p-Akt, mTOR, and Bcl-2 were decreased, whereas Bid levels were increased. Microvessel density as assessed by CD34 levels and cell growth by PCNA levels decreased according to immunohistochemical analysis. Conclusion: Hsp90B1 is a direct target of miR-223 and miR- 223 may have a tumor suppressor function in osteosarcoma through the PI3K/Akt/mTOR pathway and could be used in anticancer therapies in osteosarcoma.

 

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[190]

TÍTULO / TITLE:  - Improvement in chronic pelvic pain after gonadotropin releasing hormone analogue  (GnRH-a) administration in premenopausal women suffering from adenomyosis or endometriosis: a retrospective study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gynecol Endocrinol. 2013 Jan 17.

            ●● Enlace al texto completo (gratuito o de pago) 3109/09513590.2012.743017

AUTORES / AUTHORS:  - Morelli M; Rocca ML; Venturella R; Mocciaro R; Zullo F

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Gynecologic Oncology Unit, “Tommaso Campanella” Cancer Center of Germaneto, “Magna Graecia” University , Catanzaro ,  Italy.

RESUMEN / SUMMARY:  - Abstract The aim of this study was to evaluate the improvement in catamenial chronic pelvic pain (CPP) after Gonadotropin Releasing Hormone analogue (GnRH-a)  administration in women affected by adenomyosis or endometriosis. We retrospectively analysed clinical data of 63 premenopausal women with clinical suspect of adenomyosis (15 women, Group A) or endometriosis (48 women, Group B),  which received GnRH-a in order to reduce CPP intensity during the time on surgery waiting list. Main outcome measures were variation of CPP intensity, numbers of days requiring analgesics and lost work productivity before and three months after GnRH-a administration. Compared to baseline, a significant decrease in CPP  intensity (p < 0.05) was observed in both groups, even if this reduction was significantly higher in Group A than in Group B (p < 0.001). In both groups, moreover, a significant reduction in number of days requiring analgesics (p < 0.05) and lost work productivity (p < 0.05) was detected. In conclusion, GnRH-a administration in women with clinical suspect of adenomyosis induces a greater reduction in CPP when compared to women with endometriosis, thus representing a potential ex adiuvantibus criteria, helping TV-US in the clinical diagnosis of adenomyosis.

 

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[191]

TÍTULO / TITLE:  - Effects of TRAIL and taurolidine on apoptosis and proliferation in human rhabdomyosarcoma, leiomyosarcoma and epithelioid cell sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Oncol. 2013 Mar;42(3):945-56. doi: 10.3892/ijo.2013.1772. Epub 2013 Jan 15.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ijo.2013.1772

AUTORES / AUTHORS:  - Karlisch C; Harati K; Chromik AM; Bulut D; Klein-Hitpass L; Goertz O; Hirsch T; Lehnhardt M; Uhl W; Daigeler A

INSTITUCIÓN / INSTITUTION:  - Department of Gynecology and Obstetrics, Marienhospital Witten, Ruhr-University,  D-58452 Witten, Germany.

RESUMEN / SUMMARY:  - Soft tissue sarcomas (STS) are a heterogeneous group of malignant tumours representing 1% of all malignancies in adults. Therapy for STS should be individualised and multimodal, but complete surgical resection with clear margins remains the mainstay of therapy. Disseminated soft tissue sarcoma still represents a therapeutic dilemma. Commonly used chemotherapeutic agents such as doxorubicin and ifosfamide have proven to be effective in fewer than 30% in these cases. Therefore, we tested the apoptotic and antiproliferative in vitro effects  of TNF-related apoptosis-inducing ligand (TRAIL) and taurolidine (TRD) on rhabdomyosarcoma (A-204), leiomyosarcoma (SK-LMS-1) and epithelioid cell sarcoma  (VA-ES-BJ) cell lines. Viability, apoptosis and necrosis were quantified by FACS  analysis (propidium iodide/Annexin V staining). Gene expression was analysed by DNA microarrays and the results validated for selected genes by rtPCR. Protein level changes were documented by western blot analysis. Cell proliferation was analysed by BrdU ELISA assay. The single substances TRAIL and TRD significantly induced apoptotic cell death and decreased proliferation in rhabdomyosarcoma and  epithelioid cell sarcoma cells. The combined use of TRAIL and TRD resulted in a synergistic apoptotic effect in all three cell lines, especially in rhabdomyosarcoma cells leaving 18% viable cells after 48 h of incubation (p<0.05). Analysis of the differentially regulated genes revealed that TRD and TRAIL influence apoptotic pathways, including the TNF-receptor associated and the mitochondrial pathway. Microarray analysis revealed remarkable expression changes in a variety of genes, which are involved in different apoptotic pathways and cross talk to other pathways at multiple levels. This in vitro study demonstrates that TRAIL and TRD synergise in inducing apoptosis and inhibiting proliferation in different human STS cell lines. Effects on gene expression differ relevantly in the sarcoma entities. These results provide experimental support for in vivo trials assessing the effect of TRAIL and TRD in STS and sustain the approach of individualized therapy.

 

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[192]

TÍTULO / TITLE:  - A practical approach to immunohistochemical diagnosis of ovarian germ cell tumours and sex cord-stromal tumours.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Histopathology. 2013 Jan;62(1):71-88. doi: 10.1111/his.12052.

            ●● Enlace al texto completo (gratuito o de pago) 1111/his.12052

AUTORES / AUTHORS:  - Rabban JT; Zaloudek CJ

INSTITUCIÓN / INSTITUTION:  - Pathology Department, University of California San Francisco, San Francisco, CA,  USA. joseph.rabban@ucsf.edu

RESUMEN / SUMMARY:  - Immunohistochemistry can be useful in the diagnosis of ovarian germ cell tumours  and sex cord-stromal tumours. A wide variety of markers are available, including  many that are novel. The aim of this review is to provide a practical approach to the selection and interpretation of these markers, emphasizing an understanding of their sensitivity and specificity in the particular differential diagnosis in  question. The main markers discussed include those for malignant germ cell differentiation (SALL4 and placental alkaline phosphatase), dysgerminoma (OCT4, CD117, and D2-40), yolk sac tumour (alpha-fetoprotein and glypican-3), embryonal  carcinoma (OCT4, CD30, and SOX2), sex cord-stromal differentiation (calretinin, inhibin, SF-1, FOXL2) and steroid cell tumours (melan-A). In addition, the limited role of immunohistochemistry in determining the primary site of origin of an ovarian carcinoid tumour is discussed.

 

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[193]

TÍTULO / TITLE:  - Polymorphism of catechol-o-methyltransferase and uterine leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Cell Biochem. 2013 Mar;375(1-2):179-83. doi: 10.1007/s11010-012-1540-3. Epub  2012 Dec 14.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11010-012-1540-3

AUTORES / AUTHORS:  - Ates O; Demirturk F; Toprak M; Sezer S

INSTITUCIÓN / INSTITUTION:  - Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, 60100, Tokat, Turkey, omerates27@yahoo.com.

RESUMEN / SUMMARY:  - Uterine leiomyoma (ULM) is the most common gynecological benign tumor that is affecting around 20-50 % of women over the age of 30. Although its molecular pathogenesis is still unknown, ULM has a multifactorial etiology determined by both genetics and environmental factors. The present study was designed to find out whether Val158Met polymorphism in the catechol-o-methyltransferase (COMT) gene is associated with the risk of ULM. We analyzed COMT Val158Met polymorphism  in 105 ULMs patients and 105 healthy subjects using a polymerase chain reaction-based restriction fragment length polymorphism assay. We found remarkably similar frequencies in ULM compared with controls for COMT Val158Met genotypes and alleles, and no association was found between ULM and this polymorphism (p = 0.46). The COMT 158 Met allele in patients with large (>/=5 cm) fibroids was higher than in patients with small (<5 cm) fibroids, and significant association was found between fibroid size and COMT 158 Met allele (p = 0.011, OR 0.50, 95 %CI 0.28-0.90). Our results reflect that COMT Val158Met polymorphism is  not associated with an increased risk of ULMs, but Val158Met polymorphism may be  a risk factor for development of large fibroids in Turkish patients with ULM.

 

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[194]

TÍTULO / TITLE:  - miR-181a promotes osteoblastic differentiation through repression of TGF-beta signaling molecules.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Biochem Cell Biol. 2012 Dec 20;45(3):696-705. doi: 10.1016/j.biocel.2012.12.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.biocel.2012.12.008

AUTORES / AUTHORS:  - Bhushan R; Grunhagen J; Becker J; Robinson PN; Ott CE; Knaus P

INSTITUCIÓN / INSTITUTION:  - Institute for Chemistry and Biochemistry, Freie Universitaet Berlin, Berlin, Germany.

RESUMEN / SUMMARY:  - Osteoblastic differentiation is controlled by complex interplay of several signaling pathways and associated key transcription factors, as well as by microRNAs (miRNAs). In our current study, we found miR-181a to be highly upregulated during BMP induced osteoblastic differentiation of C2C12 and MC3T3 cells. Overexpression of miR-181a led to upregulation of key markers of osteoblastic differentiation as well as enhanced ALP levels and Alizarin red staining, indicating the importance of this miRNA for osteoblastic differentiation. Further, we show that miR-181 isoforms (181a, 181b, 181c) are expressed during different stages of mouse calvarial and tibial development, implying their role in both endochondral and intramembranous ossification. We found several direct and indirect targets of miR-181a to be downregulated by global mRNA expression profiling. Our results demonstrate that miR-181a promotes  osteoblastic differentiation via repression of TGF-beta signaling molecules by targeting the negative regulator of osteoblastic differentiation Tgfbi (Tgf-beta  induced) and TbetaR-I/Alk5 (TGF-beta type I receptor). Furthermore, our findings  suggest that Rgs4 and Gata6 are direct targets of miR-181a. Taken together, we provide evidence for a crucial functional link between a specific miRNA, miR-181a and osteoblastic differentiation.

 

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[195]

TÍTULO / TITLE:  - Prognostic role of E-cadherin and Vimentin expression in various subtypes of soft tissue leiomyosarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Mar;30(1):401. doi: 10.1007/s12032-012-0401-y. Epub 2013 Jan 5.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-012-0401-y

AUTORES / AUTHORS:  - Tian W; Wang G; Yang J; Pan Y; Ma Y

INSTITUCIÓN / INSTITUTION:  - Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China, tianweiyh@yahoo.com.

RESUMEN / SUMMARY:  - The gain of E-cadherin and loss of Vimentin known as “Cadherin switching” resulting in epithelial differentiation play an important role in tumor cell invasion and metastasis. In soft tissue leiomyosarcoma (LMS), aberrant expression of E-cadherin and down-regulation of Vimentin-related Mesenchymal to Epithelial Reverting Transition was defined, but the role of these proteins in various subtypes of LMS have not been well demonstrated yet. The aim of this study was to evaluate the prognostic role of E-cadherin and Vimentin expression in 45 soft tissue leiomyosarcoma samples by Immunohistochemistry analysis. E-cadherin was positive in a small proportion of LMS, accounting for 15.6 % (7/45). All LMS samples expressed Vimentin, concluding 20 patients as strong positive group (44.4 %), 25 patients as week positive group (55.6 %). Although the aberrant expression of E-cadherin had no differences among various subtypes of LMS, it was significantly associated with early clinical stages. The patients with strong positive expression of Vimentin suffered significant high risk of recurrence and  metastasis and also had significant worse overall survival. These data suggest that the epithelial differentiation of LMS evaluated by E-cadherin expression does not belong to certain subtypes in LMS. The patients with the gain of E-cadherin and loss of Vimentin expression represent favorable trend of survival. They might serve as good biomarkers of the LMS clinical outcome after further investigations.

 

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[196]

TÍTULO / TITLE:  - Gingival Rhabdomyosarcoma Accompanied by an Immature Myogenic Population Immunoreactive for alpha-Smooth Muscle Actin in a Dog.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Comp Pathol. 2012 Dec 27. pii: S0021-9975(12)00421-5. doi: 10.1016/j.jcpa.2012.11.233.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcpa.2012.11.233

AUTORES / AUTHORS:  - Kimura M; Suzuki K; Fujii Y; Yamamoto R; Shibutani M; Mitsumori K

INSTITUCIÓN / INSTITUTION:  - Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.

RESUMEN / SUMMARY:  - A 3-year-old female shih tzu was presented with a white to dark red mass arising  from the gingiva. Because of the rapid and invasive growth of the mass, the dog was humanely destroyed. Microscopically, round to polygonal anaplastic cells with strongly eosinophilic cytoplasm grew in an alveolar pattern separated by fibrous  stroma. Mitotic figures were numerous. Multinucleated cells and ‘strap cells’ were observed, but cross striation and glycogen accumulation were absent. Immunohistochemically, the tumour cells were positive for vimentin, desmin, muscle-specific actin and MyoD1, and a small number of tumour cells were positive for alpha-smooth muscle actin (alpha-SMA). Based on the morphological and immunohistochemical features, the gingival mass was diagnosed as alveolar rhabdomyosarcoma accompanied by alpha-SMA-positive immature myogenic cells.

 

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[197]

TÍTULO / TITLE:  - Can CT Features Differentiate Between Inferior Vena Cava Leiomyosarcomas and Primary Retroperitoneal Masses?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - AJR Am J Roentgenol. 2013 Jan;200(1):205-9. doi: 10.2214/AJR.11.7476.

            ●● Enlace al texto completo (gratuito o de pago) 2214/AJR.11.7476

AUTORES / AUTHORS:  - Webb EM; Wang ZJ; Westphalen AC; Nakakura EK; Coakley FV; Yeh BM

INSTITUCIÓN / INSTITUTION:  - Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, Box 0628, M-372, San Francisco, CA 94143-0628.

RESUMEN / SUMMARY:  - OBJECTIVE: The objective of our study was to evaluate and describe CT features that may differentiate inferior vena cava (IVC) leiomyosarcomas from primary retroperitoneal masses. MATERIALS AND METHODS: A records search revealed 18 CT examinations with a soft-tissue mass contacting the IVC. Three readers evaluated  the scans for four signs: an imperceptible IVC at the interface with the mass; a  “positive embedded organ” sign (IVC embedded in the periphery of the mass); a “negative embedded organ” sign (IVC compressed at the perimeter of the mass); and tumor in the IVC lumen. CT findings were compared with pathology and operative reports. Performance and significance of CT features and interobserver agreement  were calculated. RESULTS: Four of 18 (22%) retroperitoneal masses were IVC leiomyosarcomas. The IVC was imperceptible at the interface with the mass in three of the four (75%) IVC leiomyosarcomas (kappa = 0.88) and in no alternate diagnosis (p < 0.02). No IVC leiomyosarcoma showed a positive embedded organ sign versus one of 14 masses of alternate origin (p = 1.0, kappa = 0.56). The negative embedded organ sign was seen in most primary retroperitoneal masses (11/14 or 79%, kappa = 0.85) but in no case of IVC leiomyosarcoma (p = 0.01). Intraluminal  tumor was seen in one of four (25%) IVC leiomyosarcomas and in two of 14 other retroperitoneal masses (p = 1.0, kappa = 1.0). CONCLUSION: An imperceptible IVC at the point of maximal contact with a retroperitoneal mass was the most useful CT feature for predicting the origin of IVC leiomyosarcoma. A negative embedded organ sign was useful for excluding IVC origin. Knowledge of these CT features may assist with preoperative planning.

 

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[198]

TÍTULO / TITLE:  - Pediatric cervicomediastinal hibernoma: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Surg. 2013 Jan;48(1):258-61. doi: 10.1016/j.jpedsurg.2012.10.059.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpedsurg.2012.10.059

AUTORES / AUTHORS:  - Guidry CA; McGahren ED; Rodgers BM; Kane BJ

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Surgery, University of Virginia Department of Surgery.

RESUMEN / SUMMARY:  - Hibernoma is a rare lipomatous tumor of brown fat origin. Though uniformly benign in nature these tumors may cause symptoms secondary to extrinsic compression of neighboring structures. Hibernomas may be found anywhere that normal fetal brown  fat may be located but are most commonly located in the thigh. We present a case  of a hibernoma presenting as an unusual cervicomediastinal mass in a 6-year-old male. This mass was discovered during a diagnostic chest x-ray for pneumonia and  treated by resection. Complete surgical resection is considered curative. Hibernoma should be considered in the differential diagnosis of any lipomatous tumor.

 

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[199]

TÍTULO / TITLE:  - Primary Cutaneous Carcinosarcoma of the Shoulder: Case Report with Literature Review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dermatol Surg. 2012 Dec 3. doi: 10.1111/dsu.12023.

            ●● Enlace al texto completo (gratuito o de pago) 1111/dsu.12023

AUTORES / AUTHORS:  - Hong SH; Hong SJ; Lee Y; Kang EY

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Guro Hospital, College of Medicine, Korea University, Seoul, Korea.

 

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[200]

TÍTULO / TITLE:  - Laparoscopy-Assisted versus Open Surgery for Gastrointestinal Stromal Tumors of Jejunum and Ileum: Perioperative Outcomes and Long-Term Follow-Up Experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am Surg. 2012 Dec;78(12):1399-404.

AUTORES / AUTHORS:  - Wan P; Li C; Yan M; Yan C; Zhu ZG

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Institute of Digestive Surgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

RESUMEN / SUMMARY:  - Whether laparoscopy-assisted resections for gastrointestinal stromal tumors (GISTs) of small bowel can achieve more benefits on the aspect of postoperative outcomes than open surgery remains a question. The aim of this study is to evaluate the benefits of laparoscopy-assisted surgery for GISTs of jejunum and ileum on the perioperative outcomes and long-term relapse-free survival. From January 2004 to December 2010, 81 patients who underwent either laparoscopy-assisted (LAP group, n = 43) or open surgery (OPEN group, n = 38) were included in final analysis after the eligibility criteria. Clinicopathological characteristics of the selected patients were similar between the two groups. Oral intake was significant earlier (P < 0.001) and postoperative hospital stay duration was significantly shorter (P < 0.001) in the LAP group than in the OPEN group. The complication rate of patients in the LAP group and OPEN group was 9.3 and 26.3 per cent, respectively (P = 0.04). No significant difference was observed in terms of 5-year relapse-free survival between LAP and  OPEN groups (91.1 vs 93.8%, P = 0.4). Laparoscopy-assisted surgery for GISTs of jejunum and ileum could get preferable short-term postoperative outcomes and similar long-term relapse-free survival compared with open surgery, so it should  be recommended for GISTs of the small intestine.

 

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[201]

TÍTULO / TITLE:  - Infantile digital fibromatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Dis Child. 2012 Dec 15.

            ●● Enlace al texto completo (gratuito o de pago) 1136/archdischild-2012-303271

AUTORES / AUTHORS:  - Paloni G; Mattei I; Salmaso R; Cutrone M

INSTITUCIÓN / INSTITUTION:  - Department of Pediatrics, Institute for Maternal and Child Health - IRCCS “Burlo  Garofolo” - Trieste, University of Trieste, Italy.

 

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[202]

TÍTULO / TITLE:  - Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Food Chem Toxicol. 2013 Feb;52:193-9. doi: 10.1016/j.fct.2012.11.019. Epub 2012 Nov 28.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.fct.2012.11.019

AUTORES / AUTHORS:  - Lu KH; Yang HW; Su CW; Lue KH; Yang SF; Hsieh YS

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.

RESUMEN / SUMMARY:  - Phyllanthus urinaria is widely used as anti-inflammatory, antiviral, antibacterial, and anti-hepatotoxic medicines in almost every tropical country. However, scientific evidence supporting its use in cancer metastasis is limited,  particularly osteosarcoma. We investigated the effect of P. urinaria extract (PUE) on cell viability, invasion, and migration in the human osteosarcoma Saos-2 cell line, and looked at the impact of PUE on several relevant proteases and signaling pathways. This study demonstrates that PUE, at a range of concentrations (from 0 to 100mug/ml), concentration-dependently inhibited the migration/invasion capacities of Saos-2 without cytotoxic effects. Zymographic and western blot analyses revealed that PUE inhibited the urokinase-type plasminogen activator (u-PA) and matrix metalloproteinase-2 (MMP-2) enzyme activity, as well as protein expression. Western blot analysis also showed that PUE inhibits phosphorylation of ERK1/2 and Akt. Testing of mRNA level, quantitative real-time PCR, and promoter assays evaluated the inhibitory effects  of PUE on u-PA expression in Saos-2 cells. The chromatin immunoprecipitation (ChIP) assay was reactive to the transcription protein SP-1, which was inhibited  by PUE. In conclusion, PUE suppresses human osteosarcoma Saos-2 cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. Therefore, PUE produces anti-metastatic activity in Saos-2 cells.

 

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[203]

TÍTULO / TITLE:  - A rare case of acute pancreatitis induced by a gastrointestinal stromal tumor arising from the gastric fundus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Endoscopy. 2012 Dec;44 Suppl 2:E426-7. doi: 10.1055/s-0032-1325863. Epub 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 1055/s-0032-1325863

AUTORES / AUTHORS:  - Sun J; Shen X; Li Z; Zhu J

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, Jinan Central Hospital, Shandong University, Jinan, China.

 

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[204]

TÍTULO / TITLE:  - Echo rounds: near total occlusion of the main pulmonary artery and destruction of pulmonary valve by leiomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anesth Analg. 2013 Jan;116(1):53-6. doi: 10.1213/ANE.0b013e318274e3c7. Epub 2012  Dec 7.

            ●● Enlace al texto completo (gratuito o de pago) 1213/ANE.0b013e318274e3c7

AUTORES / AUTHORS:  - Jelacic S; Meguid RA; Oxorn DC

INSTITUCIÓN / INSTITUTION:  - Department of Anesthesiology and Pain Medicine, Division of Cardiothoracic Anesthesiology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA 98195-6540. sjelacic@uw.ed.

 

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[205]

TÍTULO / TITLE:  - Superficial angiomyxoma of the vulva complicated with condyloma acuminatum and Staphylococcus hominis infection.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Dermatol. 2013 Jan 20. doi: 10.1111/j.1365-4632.2012.05572.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1365-4632.2012.05572.x

AUTORES / AUTHORS:  - Zhu L; Zhao W; Shi Y; Lin B

INSTITUCIÓN / INSTITUTION:  - Departments of Obstetrics and Gynecology Pathology Radiology, Shengjing Hospital  Affiliated to China Medical University, Shenyang, China.

 

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[206]

TÍTULO / TITLE:  - Defective myometrial spiral artery remodelling as a cause of major obstetrical syndromes in endometriosis and adenomyosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Placenta. 2012 Dec 8. pii: S0143-4004(12)00452-3. doi: 10.1016/j.placenta.2012.11.017.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.placenta.2012.11.017

AUTORES / AUTHORS:  - Brosens I; Pijnenborg R; Benagiano G

INSTITUCIÓN / INSTITUTION:  - Leuven Institute for Fertility and Embryology, Leuven, Belgium. Electronic address: Ivo.Brosens@med.kuleuven.ac.be.

RESUMEN / SUMMARY:  - Endometriosis and adenomyosis are characterized by the presence of ectopic endometrium, but are also associated with functional and structural changes in the eutopic endometrium and inner myometrium. Alterations in the inner myometrium occurring in women with endometriosis and adenomyosis may be at the root of a defective remodelling of the myometrial spiral arteries from the onset of decidualization and result in vascular resistance and increased risk of defective deep placentation. The association of major obstetrical syndromes and different types of defective remodelling of the myometrial spiral arteries has been well documented. The possibility of a link between both endometriosis and adenomyosis  and some major obstetric syndromes remains controversial because of at least two  factors: first, changes of the inner myometrium are frequently present in women with endometriosis but the diagnosis requires high-resolution imaging such as magnetic resonance which is not routinely performed and second, patients with endometriosis are frequently subjected to prolonged hormone suppressive therapy.  Indeed, there is evidence that pre-treatment with a Gonadotropin Releasing-Hormone analogue can improve the uterine microenvironment and implantation rate following IVF in infertile patients with endometriosis.

 

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[207]

TÍTULO / TITLE:  - Rivaroxaban, a direct inhibitor of the coagulation factor Xa interferes with hormonal-induced physiological modulations in human female osteoblastic cell line SaSO(2).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Steroid Biochem Mol Biol. 2013 Jan 17. pii: S0960-0760(13)00011-3. doi: 10.1016/j.jsbmb.2013.01.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jsbmb.2013.01.006

AUTORES / AUTHORS:  - Somjen D; Katzburg S; Gigi R; Dolkart O; Sharon O; Salai M; Stern N

INSTITUCIÓN / INSTITUTION:  - Institute of Endocrinology, Metabolism and Hypertension, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel. Electronic address: dalias@tasmc.health.gov.il.

RESUMEN / SUMMARY:  - The use of anticoagulants has been associated with systemic osteoporosis and increased risk for poor fracture healing but is inevitable following major orthopedic surgery of lower limbs. Rivaroxaban A ® is an anticoagulant recently introduced in the clinical setting, which is a specific factor Xa inhibitor. We reported previously that R significantly inhibited cell growth, energy metabolism and alkaline phosphatase activity in human osteoblastic cell line SaOS(2), with no effect on mineralization, indicating transient inhibition of bone formation. We now investigated the effects of R on SaOS(2) response to osteoblast-modulating hormones. At sub-confluence cells were treated with: estradiol-17beta (E(2)), the phytoestrogens daidzein (D) and biochainin A (BA), the carboxy-pytoestrogenic derivative carboxy-D (cD), the estrogen receptor alpha (ERalpha) agonist PPT, the estrogen receptor beta (ERbeta) agonist DPN, parathyroid hormone (PTH) and several vitamin D metabolites and analogs with/without R for 24h. All hormones tested stimulated significantly DNA synthesis (DNA), creatine kinase (CK) and alkaline phosphatase (ALP) specific activities, but all these stimulations were totally inhibited when given together with R. R had no effect on mRNA expression  of ERalpha, ERbeta and 25 Hydroxy-vitamin D(3)-1alpha hydroxylase (1OHase), but inhibited hormonal modulations of mRNA expressions. In conclusion R inhibited significantly hormonal stimulation of different parameters indicating inhibition  of not only the early stages of bone formation, but also the stimulatory effects  of bone modulating hormones with a yet unclear mechanism. The relevance of these  findings to human bone physiology is yet to be investigated.

 

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[208]

TÍTULO / TITLE:  - Analysis of epidermal growth factor receptor (EGFR) status in endometrial stromal sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Gynaecol Oncol. 2012;33(6):629-32.

AUTORES / AUTHORS:  - Capobianco G; Pili F; Contini M; De Miglio MR; Marras V; Santeufemia DA; Cherchi C; Dessole M; Cherchi PL; Cossu-Rocca P

INSTITUCIÓN / INSTITUTION:  - Gynecologic and Obstetric Clinic, University of Sassari, Italy.

RESUMEN / SUMMARY:  - PURPOSE: Endometrial stromal sarcomas (ESSs) are rare neoplasms, which are currently treated by surgery, whereas effective adjuvant therapies have not yet been established. Recently, epidermal growth factor receptor (EGFR) expression has been described in ESS, and a potential role of EGFR-targeted adjuvant therapies has been proposed. The aim of this study was to analyze EGFR status in  an ESS series and to evaluate their potential role as molecular targets. MATERIALS AND METHODS: EGFR status was investigated in a total of ten cases of ESS, which included seven low-grade ESS and three undifferentiated ESS cases. EGFR expression levels were assessed by immunohistochemistry, and gene amplification analysis was performed with dual-color fluorescence in situ hybridization (FISH). RESULTS: Nine out of ten ESS cases showed positive immunostaining, whereas FISH analysis demonstrated constantly negative results. CONCLUSIONS: This study confirmed that EGFR is frequently overexpressed in ESS. FISH analysis did not show EGFR amplification in any of the tumors, therefore EGFR expression in ESS should be related to different genetic mechanisms.

 

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[209]

TÍTULO / TITLE:  - Primary Pulmonary Sarcomatoid Carcinomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Bronconeumol. 2013 Jan 24. pii: S0300-2896(12)00335-3. doi: 10.1016/j.arbres.2012.12.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.arbres.2012.12.002

AUTORES / AUTHORS:  - Avila Martinez RJ; Marron Fernandez C; Hermoso Alarza F; Zuluaga Bedoya M; Meneses Pardo JC; Gamez Garcia AP

INSTITUCIÓN / INSTITUTION:  - Servicio de Cirugia Toracica, Hospital Universitario 12 de Octubre, Madrid, España. Electronic address: reguloavila@hotmail.com.

RESUMEN / SUMMARY:  - OBJECTIVE: To describe the characteristics and the result of surgical treatment in a series of patients with primary pulmonary sarcomatoid carcinoma (PSC). METHODOLOGY: A descriptive study of 11 patients with primary PSC who were treated by the Thoracic Surgery Department at the Hospital Universitario 12 de Octubre in Madrid (Spain) between 2005 and 2009. We analyzed age, gender, histologic type, pathological stage, type of surgery and survival (in months). RESULTS: Ten patients were male and 11 were smokers; mean age of was 55. The pathologic stages were: 4 stage IIA, 3 stage IIB, 2 stage IB and 2 stage IA. The most frequent histologic type was pleomorphic carcinoma, which was found in 5 cases. Complete resection was performed in 10 cases, and 7 received adjuvant therapy. Seven are disease-free after a mean follow-up period of 49 months. CONCLUSIONS: Complete surgery in the initial stages of primary PSC can improve survival.

 

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[210]

TÍTULO / TITLE:  - Aggressive angiomyxoma of the vaginal wall at the initial stage: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Gynaecol Oncol. 2012;33(6):669-71.

AUTORES / AUTHORS:  - Carta G; Parisse V; Accurti V; Sollima L; Di Stefano L; D’Alfonso A; Patacchiola F

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Sciences, University of L’Aquila, Italy. gasparecarta@libero.it

RESUMEN / SUMMARY:  - Aggressive angiomyxoma (AA) is a rare mesenchimal tumor usually located in the pelvic and perineal region. Less than 30 cases of aggressive angiomyxoma with vaginal location have been reported in the literature up to this date. The authors report the case of a 50-year-old female patient diagnosed with vaginal AA whose characteristics at its initial stage were macroscopically indistinguishable from those of a polypoid lesion. Therefore this case suggests that this type of tumor should be considered as part of the differential diagnosis of vaginal polypoid lesions.

 

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[211]

TÍTULO / TITLE:  - St. George’s Respiratory Questionnaire has Longitudinal Construct Validity in Lymphangioleiomyomatosis*

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chest. 2013 Jan 17. doi: 10.1378/chest.12-0161.

            ●● Enlace al texto completo (gratuito o de pago) 1378/chest.12-0161

AUTORES / AUTHORS:  - Swigris JJ; Lee HS; Cohen M; Inoue Y; Moss J; Singer L; Young LR; McCormack FX

RESUMEN / SUMMARY:  - ABSTRACT BACKGROUND: Lymphangioleiomyomatosis (LAM) is an uncommon, progressive,  cystic lung disease that causes shortness of breath, hypoxemia and impaired health-related quality of life (HRQL). Whether St. George’s Respiratory Questionnaire (SGRQ)-a respiratory-specific HRQL instrument-captures longitudinal changes in HRQL in LAM patients is unknown. METHODS: Using data from the Multicenter International Lymphangioleiomyomatosis Efficacy and Safety of Sirolimus (MILES) trial, we performed analyses to examine associations between SGRQ scores and values for four external measures (anchors). Anchors included (1) the one-second forced expiratory volume (FEV1), (2) diffusing capacity of the lung for carbon monoxide, (3) distance walked during the six-minute walk test, and (4) serum vascular endothelial growth factor-D. RESULTS: SGRQ scores correlated with the majority of anchor values at baseline, 6 and 12 months. Results from longitudinal analyses demonstrated that SGRQ change scores tracked changes over time in values for each of the four anchors. At 12 months, subjects  with the greatest improvement from baseline in FEV1 experienced the greatest improvement in SGRQ scores (Symptoms domain -13.4+/-14.6 points, Activity domain  -6.46+/-8.20 points, Impacts domain -6.25+/-12.8 points, SGRQ total -7.53+/-10.0  points). Plots of cumulative distribution functions further supported the longitudinal validity of the SGRQ in LAM. CONCLUSIONS: In LAM, SGRQ scores are associated with variables used to assess LAM severity. The SGRQ is sensitive to change in LAM severity, particularly when change is defined by FEV1, perhaps the  most clinically relevant and prognostically important variable in LAM. The constellation of results here support the validity of the SGRQ as capable of assessing longitudinal change in HRQL in LAM.

 

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[212]

TÍTULO / TITLE:  - Laparoscopic versus open resection of gastrointestinal stromal tumors of the stomach.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Surg Endosc. 2012 Dec 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00464-012-2622-8

AUTORES / AUTHORS:  - De Vogelaere K; Hoorens A; Haentjens P; Delvaux G

INSTITUCIÓN / INSTITUTION:  - Department of Abdominal Surgery, UZ Brussel, Jette, Belgium, kristel.devogelaere@uzbrussel.be.

RESUMEN / SUMMARY:  - BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Surgical treatment is the only  chance of cure for patients with a primary localized GIST. A laparoscopic approach has been considered reasonable for these tumors of gastric origin. The current study compares the outcome of laparoscopic versus open resection of gastric GISTs and compares our series with the few published studies comparing the open versus the laparoscopic approach. METHODS: From a prospectively collected database, we found 53 primary gastric GIST resections that were performed in our department. Laparoscopic (LAP) resections were performed in 37 patients and traditional (OPEN) resections in 16 patients. Clinical and pathologic characteristics and surgical outcomes were analyzed according to surgical procedure. RESULTS: Patients who underwent LAP or OPEN resection of gastric GISTs did not differ with respect to age at operation, gender, clinical presentation, and tumor size. Operative time was significantly lower for LAP than for OPEN resection, with a mean duration of 45 and 132.5 min, respectively (p < 0.001). LAP resection yielded a significantly shorter length of stay (median 7 vs. 14 days; p = 0.007) and lower 30-day morbidity rate (2.7 % vs. 18.9 %; p = 0.077). The operative mortality was 12.5 % after OPEN resection and there was no  operative mortality after LAP (p = 0.087). The recurrence rate was significantly  lower after LAP surgery (0 % vs. 37.5 %; p < 0.001). All patients in the LAP group are alive without recurrence, and 25 % (4/16) of the OPEN group are alive with recurrence but in complete remission under imatinib mesylate treatment. Two  patients of the open group died due to progression of GIST (p = 0.087). CONCLUSIONS: Compared to open resection, laparoscopic resection of gastric stromal tumors is associated with a shorter operation time, a shorter hospital stay, and a lower recurrence rate.

 

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[213]

TÍTULO / TITLE:  - Muir-Torre syndrome-associated pleomorphic liposarcoma arising in a previous radiation field.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Virchows Arch. 2013 Jan 9.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00428-012-1369-x

AUTORES / AUTHORS:  - Yozu M; Symmans P; Dray M; Griffin J; Han C; Ng D; Parry S; Wong K

INSTITUCIÓN / INSTITUTION:  - Histopathology Department, Middlemore Hospital, Hospital Road, Otahuhu, Auckland, New Zealand, MasatoY@adhb.govt.nz.

RESUMEN / SUMMARY:  - Muir-Torre syndrome is a variant of Lynch syndrome, characterised by sebaceous neoplasia and/or keratoacanthomas associated with visceral malignancies. Muir-Torre syndrome is caused by germline mutations of one of the mismatch repair genes, frequently MSH2 and less frequently MLH1 and MSH6. Visceral malignancies associated with Muir-Torre syndrome and Lynch syndrome include colorectal, endometrial and other gastrointestinal, urological and gynaecological malignancies. Small numbers of Lynch syndrome-associated soft tissue sarcomas have been reported, but there are no reported cases of soft tissue sarcomas in Muir-Torre syndrome. In this study, we report a 74-year-old man with known Muir-Torre syndrome with confirmed MSH2 germline mutation, diagnosed with pleomorphic liposarcoma of the right buttock in a previous radiation field. The tumour showed loss of expression of MSH2 and MSH6 on immunohistochemistry. Immunohistochemistry on another pleomorphic liposarcoma in a different patient with no previous history of Muir-Torre syndrome or Lynch syndrome showed no loss  of expression of mismatch repair proteins. This is the first report of Muir-Torre syndrome-associated sarcoma and the first case of post-radiation sarcoma in Lynch syndrome.

 

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[214]

TÍTULO / TITLE:  - The applicability of Ki-67 marker for renal epithelioid angiomyolipoma: experience of ten cases from asingle center.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neoplasma. 2013;60(2):209-14.

AUTORES / AUTHORS:  - Xu C; Jiang XZ; Zhao HF; Zhang NZ; Ma L; Xu ZS

RESUMEN / SUMMARY:  - In order to present our experience with 10 cases of renal epithelioid angiomyolipoma (EAML) and validate the applicability of Ki-67 (proliferation marker) for EAML, we reviewed medical records of 10 consecutive cases diagnosed EAML from January 2005 to February 2012 at our department. Clinical data were collected and analyzed and pathology slides were reviewed. The immunohistochemical reactions for Ki-67 were performed and tumors showed positive expression were estimated. Active follow-up was performed to investigate the association between Ki-67 expression and the prognosis. The mean age and tumor size of the patients was 43.6 years (range 32-56) and 8.2 cm (range 2-15 cm), respectively. Seven were females while three were males. Radical nephrectomy was  performed in 6 patients, partial nephrectomy in 3, and renal artery ligation in 1. The immunohistochemical reactions for HMB-45 (Human Melanoma Black), SMA (Smooth Muscle Actin) were positive but for S-100 were negative. The number of patients showing positive/negative Ki-67 expression was 5/5. The survival rate of the positive group was 20% (1/5) while 100% (5/5) of the negative group during the median follow-up time of 26.75 months (range 1-53). Recurrence, metastasis and death due to disease occurred in 1 (10%), 3 (30%) and 4 (40%) patients, respectively. Higher expression (positive) of Ki-67 indicates the presence of EAML and poor prognosis of patients. Surgical excision including radical and partial nephrectomy is aconsiderable approach to the treatment for its malignant  potential. Keywords: renal tumor, epithelioid angiomyolipoma, clinical characteristics, Ki-67 marker, prognosis.

 

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[215]

TÍTULO / TITLE:  - A Rare Case of Ewing’s Sarcoma of the Small Intestine.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am Surg. 2013 Feb;79(2):78-9.

AUTORES / AUTHORS:  - Prasertvit S; Stoikes N

INSTITUCIÓN / INSTITUTION:  - University of Tennessee, Memphis, Tennessee, USA.

 

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[216]

TÍTULO / TITLE:  - Infantile Intracranial Aggressive Fibromatosis: Report of Two Cases with a Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Neurosurg. 2012 Dec 21.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000345594

AUTORES / AUTHORS:  - Wang B; Ma J; Jin H

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

RESUMEN / SUMMARY:  - Aggressive fibromatosis (AF) is characterized by a nonmetastatic fibroblastic proliferative lesion that is histologically benign with infiltrative growth and frequent recurrence. To our knowledge, infantile AF is rarely reported. There are no clear guidelines regarding the management and treatment strategies for intracranial infantile AF because of its rarity. In China, there are few reports  in the clinical literature concerning intracranial infantile AF. We describe 2 cases of intracranial infantile AF and review the relevant literature to better understand the pathological features, differential diagnosis and treatment of this condition.

 

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[217]

TÍTULO / TITLE:  - Osteoblastic cellular responses on ionically crosslinked chitosan-tripolyphosphate fibrous 3-D mesh scaffolds.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Biomed Mater Res A. 2013 Jan 28. doi: 10.1002/jbm.a.34559.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jbm.a.34559

AUTORES / AUTHORS:  - Pati F; Kalita H; Adhikari B; Dhara S

INSTITUCIÓN / INSTITUTION:  - School of Medical Science and Technology, Indian Institute of Technology, Kharagpur 721302, India.

RESUMEN / SUMMARY:  - Tripolyphosphate (TPP) crosslinked chitosan (CH)-based fibrous matrices have potential as bioactive scaffolds for bone tissue engineering. This study describes mechanical, biomineralization, and in vitro bone cell growth and differentiation properties of CH-TPP (chitosan-tripolyphosphate) fibrous scaffolds and compared with that of uncrosslinked CH one. The hydrated CH-TPP scaffolds were viscoelastic in nature and their compressive strength was approximately 2.9 MPa, which is greater than recent polymer experimental bone scaffolds. This improvement in mechanical properties of CH-TPP scaffold may be beneficial toward cancellous bone graft application. Furthermore, CH-TPP fibers supported in vitro biomineralization with phosphate as nucleation site; however,  no significant difference in biomineralization morphology was observed with uncrosslinked CH fibers. Interestingly, a significant improvement in cellular responses (>33% increase in cell number based on DNA quantification) was observed when osteoblast like cells were cultured on the CH-TPP scaffolds than that of CH  scaffolds without phosphate group. Enhanced osteoblastic differentiation of MG63  cells on CH-TPP scaffolds was also evidenced. Altogether, the results show that the CH-TPP fibrous scaffolds are encouraging for bone tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

 

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[218]

TÍTULO / TITLE:  - Radiofrequency Ablation for Liver Metastasis from Gastrointestinal Stromal Tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Vasc Interv Radiol. 2013 Jan 24. pii: S1051-0443(12)01221-3. doi: 10.1016/j.jvir.2012.11.021.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jvir.2012.11.021

AUTORES / AUTHORS:  - Yamanaka T; Takaki H; Nakatsuka A; Uraki J; Fujimori M; Hasegawa T; Sakuma H; Yamakado K

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu,  Mie 514-8507, Japan. Electronic address: t-yama@clin.medic.mie-u.ac.jp.

RESUMEN / SUMMARY:  - PURPOSE: To evaluate the feasibility, safety, and clinical outcomes of radiofrequency (RF) ablation for the treatment of liver metastases from gastrointestinal stromal tumor (GIST). MATERIALS AND METHODS: Seven consecutive patients with 21 GIST liver metastases received RF ablation under computed tomographic (CT) fluoroscopic guidance. Liver metastases were solitary in two patients and multiple in five patients, with a mean maximum tumor diameter of 2.2 cm+/-1.1 (range, 1.2-4.2 cm). In addition to feasibility and safety, local tumor  progression and overall and GIST-related survival associated with RF ablation were assessed. RESULTS: All liver metastases were treated in 12 RF sessions, after which contrast-enhanced CT showed disappearance of tumor enhancement. No RF procedure-related complications occurred. Local tumor progression developed in one tumor (4.8%) during the mean follow-up period of 30.6 months+/-27.5 (range, 5.9-76.4 mo). New liver metastasis in untreated liver and lung metastasis developed in one patient each. One patient died of subarachnoid hemorrhage 5.9 months after RF ablation, but no GIST-related deaths occurred. The respective overall and GIST-related survival rates were 85.7% (95% confidence interval, 33.6%-97.8%) and 100% at 1, 3, and 5 years. CONCLUSIONS: RF ablation is a feasible, safe, and useful therapeutic option for the treatment for GIST liver metastases.

 

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[219]

TÍTULO / TITLE:  - Management of uterine adenosarcomas with and without sarcomatous overgrowth.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gynecol Oncol. 2012 Dec 30. pii: S0090-8258(12)00993-6. doi: 10.1016/j.ygyno.2012.12.036.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ygyno.2012.12.036

AUTORES / AUTHORS:  - Tanner EJ; Toussaint T; Leitao MM Jr; Hensley ML; Soslow RA; Gardner GJ; Jewell EL

INSTITUCIÓN / INSTITUTION:  - Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

RESUMEN / SUMMARY:  - OBJECTIVES: Uterine adenosarcomas (AS) are rare tumors composed of malignant stromal and benign epithelial components. We sought to evaluate the role of primary surgery, adjuvant treatments, and salvage therapies for patients with uterine adenosarcomas. METHODS: We identified all patients diagnosed with AS from 1990 to 2009 at our institution. Patient demographics, surgical procedures, sites of metastatic disease, and histologic features (e.g., presence of sarcomatous overgrowth, and heterologous elements) were collected. Treatment regimens and survival outcomes were evaluated. RESULTS: Thirty-one patients were evaluable for this study: 19 (61%) received up-front treatment at our institution and 12 (39%)  received treatment for recurrent disease. Most of the up-front treated patients (15, 79%) were diagnosed with stage I disease and underwent hysterectomy (100%) with bilateral salpingo-oophorectomy (84%). Of the 19 patients treated at our institution from time of initial diagnosis, 5 (26%) patients recurred (median follow-up, 72.9months; range, 3-154). In 5 patients with sarcomatous overgrowth (AS+SO), the 2-year progression-free and overall survival rates were both 20% versus 100% for 14 patients without sarcomatous overgrowth. Responses to systemic treatment of measurable disease were observed in patients with and without sarcomatous overgrowth, but no optimal treatment strategy could be identified for either groups. CONCLUSIONS: Unlike AS without sarcomatous overgrowth, AS+SO is an aggressive disease with a high recurrence rate. In our series, no optimal adjuvant or systemic treatment strategy was identifiable but standard sarcoma chemotherapy regimens appear to have efficacy in both AS and AS+SO.

 

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[220]

TÍTULO / TITLE:  - Transaortic video-assisted resection of a recurrent left ventricular myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Surg. 2013 Jan;95(1):340-2. doi: 10.1016/j.athoracsur.2012.04.144. Epub 2012 Dec 25.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.athoracsur.2012.04.144

AUTORES / AUTHORS:  - Schroder C; Leukhardt WH; Hsiao EM; Farah MG; Markowitz AH

INSTITUCIÓN / INSTITUTION:  - Division of Thoracic and Esophageal Surgery, University Hospitals Case Medical Center, Cleveland, Ohio. Electronic address: carsten.schroeder@uhhospitals.org.

RESUMEN / SUMMARY:  - An asymptomatic 57-year-old woman presented for resection of a fifth cardiac myxoma. To avoid complete redissection of the heart, we proposed a video-assisted transaortic approach for a recurrent left ventricle (LV) myxoma resection. In a hybrid approach, sternotomy and open aortotomy provided the minimally invasive transaortic access to the myxoma. The myxoma was discovered during a routine echocardiographic screening. A 30 degrees 5-mm scope, video-assisted thoracic surgery graspers, and endoshears were used for resection. The video-assisted technique significantly enhanced the intracardiac visualization, and a smaller, second myxoma was discovered after resection of the primary lesion. Both myxoma beds were additionally ablated to prevent recurrence. The total video-assisted operating time was 58 minutes. The transaortic valve approach avoided an atriotomy or ventriculotomy in a fifth redo operation. A transaortic valve approach to LV intracardiac lesions is safe and feasible, and it provides excellent visibility for complex cardiac cases.

 

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[221]

TÍTULO / TITLE:  - Delayed development of a rhabdomyosarcoma following radiation for a spinal cord glioma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurooncol. 2013 Jan 8.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11060-012-1042-x

AUTORES / AUTHORS:  - Mazbani E; Jones RL; Fink J; Chamberlain MC

INSTITUCIÓN / INSTITUTION:  - Department of Medicine, University of Washington, Seattle, WA, USA.

RESUMEN / SUMMARY:  - Radiation-induced sarcomas represent a rare delayed-late secondary complication of radiation therapy. Radiation-associated sarcomas are associated with a worse overall prognosis compared to sporadic sarcomas irrespective of histological type. Herein we report a case of a 65-year old man who underwent surgery and radiation therapy for a T4 spinal cord low-grade two astrocytoma in 1965 and presented over 40 years later with spinal cord complex intramedullary tumor involving the thoracic cord with drop metastases in the lumbar spine. Histology from a partial resection of the thoracic spinal tumor revealed a high-grade rhabdomyosarcoma. In addition to the rarity of radiation-induced sarcoma arising  following the treatment of a spinal cord glioma, this case study represents one of the first reports of a spinal cord rhabdomyosarcoma arising in this setting.

 

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[222]

TÍTULO / TITLE:  - Erratum to: Delayed development of a rhabdomyosarcoma following radiation for a spinal cord glioma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurooncol. 2013 Jan 22.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11060-013-1053-2

AUTORES / AUTHORS:  - Marzbani E; Jones RL; Fink J; Chamberlain MC

INSTITUCIÓN / INSTITUTION:  - Department of Medicine, University of Washington, Seattle, WA, USA.

 

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[223]

TÍTULO / TITLE:  - Primary angiosarcoma of the esophagus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Surg. 2013 Jan;95(1):e19-20. doi: 10.1016/j.athoracsur.2012.07.068. Epub 2012 Dec 25.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.athoracsur.2012.07.068

AUTORES / AUTHORS:  - Chan Y; El-Zimaity H; Darling GE

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada. Electronic address: yin.chan@utoronto.ca.

RESUMEN / SUMMARY:  - Primary angiosarcoma of the esophagus is an extremely rare soft-tissue tumor with no previously documented cases in the MEDLINE and EMBASE databases as of April 2012. We report a case of primary esophageal angiosarcoma in an otherwise healthy 77-year-old woman presenting with odynophagia and epigastric discomfort.

 

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[224]

TÍTULO / TITLE:  - Pre-osteoblastic cell response on three-dimensional, organic-inorganic hybrid material scaffolds for bone tissue engineering.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Biomed Mater Res A. 2013 Jan 27. doi: 10.1002/jbm.a.34516.

            ●● Enlace al texto completo (gratuito o de pago) 1002/jbm.a.34516

AUTORES / AUTHORS:  - Terzaki K; Kissamitaki M; Skarmoutsou A; Fotakis C; Charitidis CA; Farsari M; Vamvakaki M; Chatzinikolaidou M

INSTITUCIÓN / INSTITUTION:  - Department of Materials Science and Technology, University of Crete, P.O. Box 2208, GR-71303 Heraklio, Greece; Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology Hellas (FORTH), Greece.

RESUMEN / SUMMARY:  - Engineering artificial scaffolds that enhance cell adhesion and growth in three dimensions is essential to successful bone tissue engineering. However, the fabrication of three-dimensional (3D) tissue scaffolds exhibiting complex micro-  and nano-features still remains a challenge. Few materials can be structured in three dimensions, and even those have not been characterized for their mechanical and biological properties. In this study, we investigate the suitability of three novel materials of different chemical compositions in bone tissue regeneration: a hybrid material consisting of methacryloxypropyl trimethoxysilane and zirconium propoxide, a hybrid organic-inorganic material of the above containing 50 mole% 2-(dimethylamino)ethyl methacrylate (DMAEMA) and a pure organic material based on polyDMAEMA. More specifically, we study the mechanical properties of the aforementioned materials and evaluate the biological response of pre-osteoblastic cells on them. We also highlight the use of a 3D scaffolding technology, Direct femtosecond Laser Writing (DLW), to fabricate complex structures. Our results show that, while all three investigated materials could potentially be used as biomaterials in tissue engineering, the 50% DMAEMA composite exhibits the best mechanical properties for structure fabrication with DLW and strong biological response. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

 

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[225]

TÍTULO / TITLE:  - Langerhans Cell Sarcoma in the Cervical Lymph Node: A Case Report and Literature  Review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Haematol. 2012 Nov 27;129(2):114-120.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000342103

AUTORES / AUTHORS:  - Wang YN; Zhou XG; Wang Z

INSTITUCIÓN / INSTITUTION:  - Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

RESUMEN / SUMMARY:  - Langerhans cell sarcoma (LCS) is extremely rare, with only 36 cases reported in English literature. In this report we represent the case of a 77-year-old woman with a 1-month history of left neck swelling and pain. A diagnosis of LCS was rendered from pathological findings of the cervical lymph node biopsy. The patient’s condition deteriorated rapidly and she died 2 days after diagnosis. A literature review in the context of the present case was performed to better enhance understanding of the early diagnosis and treatment of this unusual lesion.

 

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[226]

TÍTULO / TITLE:  - Education and imaging: gastrointestinal: leiomyoma of the oesophagus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastroenterol Hepatol. 2012 Dec;27(12):1873.

AUTORES / AUTHORS:  - Abbas SM; Martin D; Leong RW; Wettstien A

INSTITUCIÓN / INSTITUTION:  - Gastroenterology and Liver Service, Concord Hospital, Sydney, NSW, Australia.

 

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[227]

TÍTULO / TITLE:  - Biomimetic coating with phosphoserine-tethered poly(epsilon-lysine) dendrons on titanium surfaces enhances Wnt and osteoblastic differentiation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Oral Implants Res. 2012 Dec 5. doi: 10.1111/clr.12075.

            ●● Enlace al texto completo (gratuito o de pago) 1111/clr.12075

AUTORES / AUTHORS:  - Galli C; Piemontese M; Meikle ST; Santin M; Macaluso GM; Passeri G

INSTITUCIÓN / INSTITUTION:  - Department of Biotechnology, Biomedical and Translational Sciences, University of Parma, Parma, Italy.

RESUMEN / SUMMARY:  - OBJECTIVES: Phosphoserine-based functionalization has been proposed as a tool to  improve integration of endosseous implants by promoting osteoblast adhesion and differentiation in vitro. The present work investigates whether phosphoserine-tethered poly(epsilon-lysine) dendrons, when applied as a film to titanium surfaces, enhance the differentiation of osteoblastic cells and the activation of Wnt/beta-catenin signaling. MATERIALS AND METHODS: These films were tested in a murine model of calvaria-derived MC3T3 osteoblastic cells, primary bone marrow cells and mesenchymal, undifferentiated C2C12 cells. Gene expression  was assayed by Real Time PCR, and activation of Wnt signaling pathway was measured with a reporter assay. RESULTS: Dendrons increased expression of alkaline phosphatase and osteocalcin, two osteoblastic markers, in both murine osteoblastic MC3T3 cells and primary bone marrow cells. The expression of osteoprotegerin, a protein opposing osteoclastogenesis was also significantly higher in cells growing on dendron-coated substrates both at 3 and 6 days of culture. Similarly, the mRNA levels of Wisp-2 and of beta-catenin, two Wnt target genes, were also markedly increased in this group at day 6. The activation of this signaling pathway in cells growing on the dendron-coated surfaces was confirmed by use of a TCF/beta-catenin reporter system in the C2C12 cell line. CONCLUSIONS: The findings of the present study show that phosphoserine-tethered poly(epsilon-lysine) dendron films act as stimuli for the activation of specific  signal cascades and promote the differentiation of adhering progenitor cells into an osteoblastic phenotype.

 

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[228]

TÍTULO / TITLE:  - Embryonal rhabdomyosarcoma of the auricle in a child.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Int. 2012 Dec;54(6):945-7. doi: 10.1111/j.1442-200X.2012.03621.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1442-200X.2012.03621.x

AUTORES / AUTHORS:  - Crozier E; Rihani J; Koral K; Cope-Yokoyama S; Rakheja D; Ulualp SO

INSTITUCIÓN / INSTITUTION:  - Departments of Otolaryngology-Head and Neck Surgery Radiology Pathology, University of Texas Southwestern Medical Center Children’s Medical Center, Dallas, Texas, USA.

RESUMEN / SUMMARY:  - We describe the diagnosis and management of a child with embryonal rhabdomyosarcoma of the auricle and emphasize both clinical and radiological findings of this rare condition. A nine-year-old boy presented for evaluation of  a slowly enlarging left auricle mass. The mass was nodular, violaceous, semi-translucent, and hyperpigmented with an overlying pseudo-vesicular plaque. The mass appeared to involve the left cavum concha, root of the helix, superior aspect of the external auditory canal, the tragus and extend to a deep preauricular component. MR imaging documented a lobulated soft tissue mass surrounding the external auditory canal with superficial involvement of the pinna. Incisional biopsy of the mass suggested embryonal rhabdomyosarcoma. The tumor was completely removed by total auriculectomy and lateral temporal bone resection. The final diagnosis was embryonal habdomyosarcoma. Although rare, otolaryngologists, pediatricians, and radiologists need to consider rhabdomyosarcoma in the differential diagnosis of auricle mass in children.

 

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[229]

TÍTULO / TITLE:  - Prognostic factors in surgically managed gastrointestinal stromal tumours.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Int Med Res. 2012;40(5):1904-11.

AUTORES / AUTHORS:  - Wu XJ; Zhang RX; Chen G; Fang YJ; Ding PR; Li LR; Lu ZH; Kong LH; Pan ZZ; Wan DS

INSTITUCIÓN / INSTITUTION:  - Department of Colorectal Surgery, Cancer Centre, Sun Yat-sen University/State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, China.

RESUMEN / SUMMARY:  - OBJECTIVE: To determine prognostic factors associated with survival in patients with surgically managed gastrointestinal stromal tumours (GISTs). METHODS: This retrospective study included 374 patients with pathologically confirmed GISTs. Medical records were reviewed and prognostic factors associated with adverse outcomes were determined. RESULTS: A total of 337 patients underwent complete resection with curative intent; 37 underwent incomplete resection. Overall mean survival time was 127.3 months; 5-year survival rate was 70.4%. Multivariate analyses determined that tumour size, risk status (of recurrence or metastasis) and surgical procedure were significant predictive factors for survival. There was a significant difference in the 5-year survival rate between patients who received adjuvant imatinib compared with those who did not (75.1% versus 13.8%).  CONCLUSIONS: Patients with GISTs managed by surgical resection combined with targeted chemotherapy had a good prognosis. Clinical factors predictive of survival included tumour size, risk status and surgical procedure.

 

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[230]

TÍTULO / TITLE:  - Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Mar;30(1):412. doi: 10.1007/s12032-012-0412-8. Epub 2013 Jan 18.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-012-0412-8

AUTORES / AUTHORS:  - Cantile M; Marra L; Franco R; Ascierto P; Liguori G; De Chiara A; Botti G

INSTITUCIÓN / INSTITUTION:  - Pathology Unit, National Cancer Institute “Fondazione G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy.

RESUMEN / SUMMARY:  - Soft tissue tumors are a heterogeneous group of tumors, traditionally classified  according to morphology and histogenesis. Molecular classification divides sarcomas into two main categories: (a) sarcomas with specific genetic alterations and (b) sarcomas showing multiple complex karyotypic abnormalities without any specific pattern. Most chromosomal alterations are represented by translocations  which are increasingly detected. The identification of fusion transcripts, in fact, not only support the diagnosis but also provides the basis for the development of new therapeutic strategies aimed at blocking aberrant activity of  the chimeric proteins. One of the genes most susceptible to breakage/translocation in soft tissue tumors is represented by Ewing sarcoma breakpoint region 1 (EWSR1). This gene has a large number of fusion partners, mainly associated with the pathogenesis of Ewing’s sarcoma but with other soft tissue tumors too. In this review, we illustrate the characteristics of this gene/protein, both in normal cellular physiology and in carcinogenesis. We describe the different fusion partners of EWSR1, the molecular pathways in which  is involved and the main molecular biology techniques for the identification of fusion transcripts and for their inhibition.

 

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[231]

TÍTULO / TITLE:  - Synchronous intrathyroid metastasis from undifferentiated endometrial sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Thyroid. 2013 Jan 29.

            ●● Enlace al texto completo (gratuito o de pago) 1089/thy.2012.0594

AUTORES / AUTHORS:  - Simon C; Grunenwald S; Soule-Tholy M; Escourrou G; Vezzosi D; Deslandres M; Vidal F; Bennet A; Caron PJ

INSTITUCIÓN / INSTITUTION:  - CHU Larrey, Department of Endocrinology and Metabolic diseases, Toulouse, France; cynthia2@hotmail.fr.

RESUMEN / SUMMARY:  - We read with interest the article by Chung et al. published in a recent issue of  Thyroid (1). Thyroid metastases are not uncommon, with a prevalence between 1 and 24% depending on the autopsy series. The most common malignancies that metastasize to the thyroid gland are renal cell, colorectal, lung, and breast carcinomas. Uterine sarcomas are rare, accounting for 3%-7% of all uterine malignancies, and are aggressive tumors with high metastatic potential (2). They  are a heterogeneous group consisting mainly of leiomyosarcoma, endometrial stromal sarcoma, adenosarcoma, and undifferentiated endometrial sarcoma. There have been only four previous publications on thyroid metastases of leiomyosarcoma (3-6). We describe here synchronous intrathyroid metastasis from undifferentiated endometrial sarcoma.

 

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[232]

TÍTULO / TITLE:  - Solitary fibrous tumour of the mediastinal pleura: the origin detected with three-dimensional computed tomography angiography.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cardiothorac Surg. 2012 Dec 12.

            ●● Enlace al texto completo (gratuito o de pago) 1093/ejcts/ezs627

AUTORES / AUTHORS:  - Nakamura S; Taniguchi T; Yokoi K

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

 

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[233]

TÍTULO / TITLE:  - Alveolar soft part sarcoma with breast metastases: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Mar;30(1):342. doi: 10.1007/s12032-012-0342-5. Epub 2012 Dec 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-012-0342-5

AUTORES / AUTHORS:  - Orphanos G; Ioannidis G; Ioannou R; Zouvani I

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, Ygia Polyclinic, 21 Nafpliou Street, 3025, Limassol, Cyprus, yiorgosorphanosvp@hotmail.com.

RESUMEN / SUMMARY:  - Alveolar soft part sarcoma (ASPS) is a rare mesenchymal tumor, accounting for <1  % of all soft tissue sarcomas. It appears mainly in young adults, has a female predominance and follows an indolent natural history. Like other sarcomas, it can metastasize to the lungs, liver, bones and the brain, but unusual sites have also been described, including the vagina, the orbit, colonic mucosa and the breast. This paper presents a case report of a 31-year-old patient with metastatic ASPS,  who developed two highly vascular breast nodules that following an excisional biopsy, were shown to represent metastases from the patient’s known sarcoma.

 

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[234]

TÍTULO / TITLE:  - Huge desmoplastic fibroma of the paediatric mandible: Surgical considerations and follow-up in three cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniomaxillofac Surg. 2012 Dec 4. pii: S1010-5182(12)00237-5. doi: 10.1016/j.jcms.2012.10.019.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcms.2012.10.019

AUTORES / AUTHORS:  - Ferri A; Leporati M; Corradi D; Ferri T; Sesenna E

INSTITUCIÓN / INSTITUTION:  - Maxillo-Facial Surgery Division, Head and Neck Department (Head: Prof. Enrico Sesenna), University Hospital of Parma, via Gramsci 14, 43100 Parma, Italy. Electronic address: a.ferri@libero.it.

RESUMEN / SUMMARY:  - The desmoplastic fibroma is a rare locally aggressive spindle-cell proliferation  made up of fibroblasts/myofibroblasts immersed in a dense collagenic stroma. Head and neck localisation of desmoplastic fibromas is even more rare and the literature is limited to small case series and reviews. A comprehensive review of the English literature from 1968 to 2011 revealed only 79 cases of mandibular desmoplastic fibromas and only 18 (22%) in patients under 4 years of age. Complete resection with clear margins is the surgical first option, but it can be difficult to achieve in the paediatric mandible, especially for giant tumours as  the three reported here. Mandibular reconstruction in these cases is mandatory to ensure correct craniofacial development. The authors present three cases of huge  mandibular desmoplastic fibromas in paediatric patients treated with mandibulectomy and immediate reconstruction using rib grafts. Indications, reconstructive options and results are discussed.

 

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[235]

TÍTULO / TITLE:  - Bilateral Psammomatoid Ossifying Fibroma: A Case Report and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Maxillofac Surg. 2012 Dec 12. pii: S0278-2391(12)01498-X. doi: 10.1016/j.joms.2012.10.010.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.joms.2012.10.010

AUTORES / AUTHORS:  - Bablani D; Desai R; Bansal S; Andrade NA

INSTITUCIÓN / INSTITUTION:  - Assistant Professor, Department of Oral Pathology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India. Electronic address: deepikabablani@gmail.com.

 

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[236]

TÍTULO / TITLE:  - Levonorgestrel-releasing intrauterine device is an efficacious contraceptive for  women with leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Int Med Res. 2012;40(5):1966-72.

AUTORES / AUTHORS:  - Xie ZW; Zhang YN; Wan S; Xu WZ; Chen J

INSTITUCIÓN / INSTITUTION:  - Women’s Hospital, College of Medicine, Zhejiang University, Zhejiang, Hangzhou, China.

RESUMEN / SUMMARY:  - OBJECTIVE: To evaluate the efficacy of a levonorgestrel-releasing intrauterine device (LNG-IUD) as contraception for women with uterine leiomyoma. METHODS: Thirty women with uterine leiomyoma requiring contraception were enrolled and had a LNG-IUD inserted. Menstrual blood volume (assessed by a pictorial blood loss assessment chart [PBAC]), haemoglobin concentration, volume of uterus and leiomyoma were determined before and after LNG-IUD insertion. RESULTS: The median (range) PBAC score was 145.0 (60.0-232.0) before LNG-IUD insertion, which significantly decreased to 44.0 (0.0-99.0) and 36.0 (0.0-90.0) after 6 and 12 months of LNG-IUD use, respectively. Prior to LNG-IUD insertion, the median haemoglobin concentration in patients with anaemia was 100.0 (69.0-109.0) g/l and this increased significantly after 6 and 12 months of LNG-IUD use, to 117.5 (101.0-131.0) g/l and 119.5 (108.0-135.0) g/l, respectively. There were no significant changes in uterine or leiomyoma volumes. No patient became pregnant and there were no severe side-effects; one IUD was expulsed. CONCLUSION: The LNG-IUD may be a safe and effective contraceptive for women of reproductive age with uterine leiomyoma.

 

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[237]

TÍTULO / TITLE:  - Clusterin expression in elastofibroma dorsi.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Histol Histopathol. 2013 Jan 24.

AUTORES / AUTHORS:  - Aigelsreiter A; Pichler M; Pixner T; Janig E; Schuller M; Lackner C; Scheipl S; Beham A; Regauer S

INSTITUCIÓN / INSTITUTION:  - Institute of Pathology, Medical University of Graz, Austria. ariane.aigelsreiter@klinikum-graz.at.

RESUMEN / SUMMARY:  - Background: Elastofibroma dorsi is a benign soft tissue lesion composed of abnormal elastic fibers. Degenerated elastic fibers in skin and liver are associated with clusterin, an apoprotein that shares functional properties with small heat shock proteins. We evaluated the staining pattern and possible role of clusterin in elastofibroma dorsi. Material and methods: Twenty-one subcutaneous elastofibromas from the scapular region were evaluated with Elastica van Gieson and Orcein stains, immunohistochemically with antibodies to clusterin, smooth muscle actin, S-100, vimentin and CD34 and correlated with clinical data with respect to physical trauma. Results: Clusterin correlated with the staining pattern of Elastica van Gieson and labelled abnormal broad coarse fibrillar and globular elastic fibers in all elastofibromas. Orcein stains additionally identified fine oxytalan fibers which were not stained by clusterin. Clusterin staining was observed only on the outside of the elastin fibers, while the cores  of fibers and globules were unstained. 4/21 elastofibromas showed cellular nodules with a myxoid/ collagenous stroma. The round to oval cells showed cytoplasmic staining with vimentin and clusterin; CD34 labelled mostly cell membranes. The cells lacked SMA and S-100 expression. The central areas of the nodules were devoid of elastic fibers, but the periphery contained coarse fibers  and globules. 9/ 11 patients, for whom clinical data were available, reported trauma to the scapular region. Conclusion: Many investigated ED were associated with trauma, which supports a reactive/ degenerative etiology of ED. The abnormal large elastic fibers in all ED were enveloped by clusterin. Clusterin deposition  may protect elastic fibers from degradation and thus contribute indirectly to the tumor-like presentation of ED.

 

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[238]

TÍTULO / TITLE:  - Sphingolipid Content in the Human Uterus and Pair-Matched Uterine Leiomyomas Remains Constant.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Lipids. 2012 Dec 14.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11745-012-3746-2

AUTORES / AUTHORS:  - Pawel K; Chabowski A; Gorski J

INSTITUCIÓN / INSTITUTION:  - Department of Gynecology and Gynecological Oncology, Medical University of Bialystok, 24a Sklodowskiej Str., 15-269, Bialystok, Poland.

RESUMEN / SUMMARY:  - In the present work we sought to investigate the content of sphingolipids (sphingosine, sphinganine, sphingosine-1-phosphate and ceramide) in human fibroids and pair-matched healthy uterus tissue. We demonstrated that, in uterine leiomyomas, the contents of sphingosine, sphinganine, sphingosine-1-phosphate and ceramide remains quite constant. However, a trend towards elevation of ceramide and simultaneous reduction of sphingosine-1 phosphate levels was also noticed. Additionally, in uterine leiomyomas we found relevant activation of both PTEN and MAPK(ERK1/2) signaling pathways with only a minor change in AKT activity and relatively absent HIF-1alpha/AMPK activation. In conclusion, rather modest changes in sphingolipids are correlated with the activation of PTEN and MAPK(ERK1/2) signaling proteins in human uterine leiomyomas.

 

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[239]

TÍTULO / TITLE:  - Complete Response to Second Line Paclitaxel Every 2 Weeks of Eyelid Kaposi Sarcoma: A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ophthal Plast Reconstr Surg. 2012 Dec 14.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IOP.0b013e3182776f32

AUTORES / AUTHORS:  - Brunetti AE; Attilio G; Vito L; Carla M; Angela S; Ilaria M; Nicola S

INSTITUCIÓN / INSTITUTION:  - *Scientific Direction, daggerHematology Unit, double daggerMedical and Experimental Oncology Unit, Cancer Institute “Giovanni Paolo II”, Bari, Italy.

RESUMEN / SUMMARY:  - A 77-year-old male patient presented to our attention with violaceous nodular lesions on the skin of his hands and lower extremities. Clinical and histologic examination supported the diagnosis of Kaposi sarcoma. A first-line systemic chemotherapy based on liposomal doxorubicin at a dosage of 40 mg/m every 3 weeks  for 5 cycles was carried out, resulting in partial resolution of skin lesions. However, 1 year later, a relapse of the disease in the lower limbs and a new lesion of the left eyelid were found, therefore the patient began a second-line therapy with 100 mg/m paclitaxel every 2 weeks. After 8 cycles of therapy, we observed a complete remission of eyelid tumor and a partial response of lower limbs lesions up to 6 months of follow up. In conclusion, eyelid Kaposi sarcoma was successfully treated with paclitaxel every 2 weeks, obtaining a complete response.

 

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[240]

TÍTULO / TITLE:  - Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Dermatol. 2013 Jan;52(1):93-5. doi: 10.1111/j.1365-4632.2012.05675.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1365-4632.2012.05675.x

AUTORES / AUTHORS:  - Gomez-Moyano E; Vera-Casano A; Sanz-Trelles A; Martinez L

INSTITUCIÓN / INSTITUTION:  - Departments of Dermatology Pathology, Hospital Carlos Haya, Malaga, España.

RESUMEN / SUMMARY:  - Background Poor prognostic factors in Merkel cell carcinoma include male sex, advanced stage at diagnosis, large tumor size (>5 mm), diffuse growth pattern, heavy lymphocytic infiltrate, and high mitotic rate. To date only six cases of Merkel cell carcinoma with sarcomatous or pseudosarcomatous differentiation and poor prognosis have been documented. Methods We present a new case of Merkel cell carcinoma with sarcomatous differentiation. Results The immunohistochemical staining patterns reflected the morphologic differentiation of the epithelial and sarcomatous pattern. After two months of follow-up, there were no signs of local  recurrence or metastases. Conclusion In all cases of merkelomas with sarcomatous  differentiation described to date, lymph node metastases have been found, except  in the presented case. However, larger series of cases will be required to determine if sarcomatous differentiation represents another negative prognostic factor.

 

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[241]

TÍTULO / TITLE:  - Coexistence of gastrointestinal stromal tumors and gastric adenocarcinomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tumour Biol. 2013 Jan 3.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13277-012-0627-5

AUTORES / AUTHORS:  - Yan Y; Li Z; Liu Y; Zhang L; Li J; Ji J

INSTITUCIÓN / INSTITUTION:  - Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Surgery, Beijing Cancer Hospital and Institute, Peking  University School of Oncology, Beijing, China.

RESUMEN / SUMMARY:  - The purpose of this study is to detect the clinicopathology of gastrointestinal stromal tumors (GISTs) occurring synchronously with gastric adenocarcinomas and to unveil the potential underlying relationship between the synchronous GIST and  gastric adenocarcinoma. This study included 15 patients with incidental GISTs found during operations for gastric adenocarcinoma and 30 patients who underwent  gastrectomy for gastric cancer without discovering GIST between January 2005 and  December 2010 at the Beijing Cancer Institute. We collected the clinicopathological data and analyzed the KIT/PDGFRA mutational status of GISTs,  corresponding gastric adenocarcinoma specimens, and the normal tissue around the  cancer lesions. Additionally, as a control group, the mutational status of the patients with gastric adenocarcinoma and no other tumors was assayed. Overall, 18 GISTs were found in 15 gastric adenocarcinoma patients. Multiple GIST lesions were found in three cases (20 %). The patients’ age ranged from 46 to 85 years, with an average of 67.6 years. The average size of the GISTs was 0.85 cm. All mesenchymal lesions showed low proliferative activity, were of low or very low risk, and were identified as CD117-positive by immunostaining. In GIST lesions, mutations in KIT were detected in 7 out of 13 cases, and of these mutations, 6 were found in exon 11 (46.2 %), and 1 was found in exon 9 (7.7 %). A total of five deletions and one point mutation were in exon 11, and one insertion was in exon 9. Mutations were not detected in exon 17 or 13 of KIT. There was no remarkable mutation analyzed in the gastric adenocarcinoma lesions or normal tissues from either the test or control groups. Clinicopathological profiles and  molecular analysis of KIT/PDGFRA showed no obvious relationship between gastric cancer and GISTs in tumor genesis, such as similar oncogene mutations.

 

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[242]

TÍTULO / TITLE:  - Effects of Kruppel-like factor 6 on osteosarcoma cell biological behavior.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tumour Biol. 2013 Jan 16.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13277-013-0651-0

AUTORES / AUTHORS:  - Jianwei Z; Enzhong B; Fan L; Jian L; Ning A

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, Affiliated Hospital of Nantong University, 20 Xishi Road, Nantong, 226001, Jiangsu Province, People’s Republic of China, zhujianwei_nt@163.com.

RESUMEN / SUMMARY:  - Kruppel-like factor 6 (KLF6) is a tumor suppressor gene frequently downregulated  in a number of human cancers, including osteosarcoma. However, the role of KLF6 in osteosarcoma remains unclear. This study was aimed at investigating the effects of KLF6 on osteosarcoma cell biological behavior. First, the expression of KLF6 in osteosarcoma cell lines (MG63, SaOS-2, U2OS, and HOS) and a human osteoblastic cell line (hFOB1.19) was detected by Western blotting. Results showed that KLF6 displayed a significant downregulation in osteosarcoma cell lines (MG63, SaOS-2, U2OS, and HOS) compared with human osteoblastic cell line (hFOB1.19). To investigate the role of KLF6 in osteosarcoma cell proliferation, apoptosis, and invasion, we generated human osteosarcoma MG63 cells in which KLF6 was either overexpressed or depleted. The MG63 cell viability, cycle, apoptosis,  and invasive ability were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide staining, propidium  iodide (PI) staining, Annexin-V-FITC/PI double staining, and Transwell invasion experiment, respectively. Results showed that the viability, proliferation, and invasive abilities were suppressed, and the apoptosis was enhanced in MG63 cells  with overexpression of KLF6. The viability, proliferation, and invasive abilities were improved, and the apoptosis was inhibited in MG63 cells with knockdown of KLF6. At the same time, these molecules, including p21, bcl-2, and MMP-9, associated with the events about cell cycle, apoptosis, and invasion, were detected. Results showed that the expressions of bcl-2 and MMP-9 were downregulated, and the expressions of p21 were upregulated in the MG-63 cells with overexpression of KLF6. Taken together, our results suggested that KLF6 could inhibit proliferation and invasion, and facilitate apoptosis of osteosarcoma cells, which might be a potential target for the treatment of osteosarcoma.

 

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[243]

TÍTULO / TITLE:  - Infantile myofibromatosis: report on a family with autosomal dominant inheritance and variable penetrance.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Surg. 2012 Dec;47(12):2312-5. doi: 10.1016/j.jpedsurg.2012.09.046.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpedsurg.2012.09.046

AUTORES / AUTHORS:  - Kulkarni K; Desai S; Grundy P; Sergi C

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Oncology, Stollery Children Hospital, University of Alberta, Edmonton, AB, Canada.

RESUMEN / SUMMARY:  - Infantile myofibromatosis (IM) is a benign tumor occurring in infants and young children. Familial IM is rare and the inheritance pattern of IM is unclear. We report on a unique family with four individuals having IM of varying degrees of severity with autosomal dominant inheritance pattern and variable penetrance.

 

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[244]

TÍTULO / TITLE:  - Successful surgical removal of an intravenous leiomyoma extending to the right atrium 4 years after hysterectomy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Cardiothorac Surg. 2013 Jan 8.

            ●● Enlace al texto completo (gratuito o de pago) 1093/ejcts/ezs610

AUTORES / AUTHORS:  - Kikuchi C; Asami F; Hanzawa K; Tsuchida M

INSTITUCIÓN / INSTITUTION:  - Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan.

 

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[245]

TÍTULO / TITLE:  - Brachytelephalangic chondrodysplasia punctata: a case series to further delineate the phenotype: note of concern.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Dysmorphol. 2013 Jan;22(1):44. doi: 10.1097/MCD.0b013e32835bc248.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MCD.0b013e32835bc248

 

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[246]

TÍTULO / TITLE:  - Superficial small round-cell tumors with special reference to the Ewing’s sarcoma family of tumors and the spectrum of differential diagnosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Semin Diagn Pathol. 2013 Feb;30(1):85-94. doi: 10.1053/j.semdp.2012.01.007.

            ●● Enlace al texto completo (gratuito o de pago) 1053/j.semdp.2012.01.007

AUTORES / AUTHORS:  - Machado I; Traves V; Cruz J; Llombart B; Navarro S; Llombart-Bosch A

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Instituto Valenciano de Oncologia, Valencia, España.

RESUMEN / SUMMARY:  - Superficial/cutaneous small round-cell tumors comprise a heterogeneous group of neoplasms including sarcoma, carcinoma, melanoma, and lymphomas. Among superficial sarcomas, the Ewing’s sarcoma family of tumors (ESFT) represents a poorly understood rare variant, having a behavioral difference characterized by a relative favorable prognosis. Several problems are still to be resolved in superficial ESFT, including the differential diagnosis between ESFT of bone (intraosseous or periosteal) with superficial infiltration and superficial ESFT with bone infiltration, especially in the fingers. Our aim is to review the most  common types of small round-cell tumors included in the differential diagnosis of superficial ESFT, analyzing the histopathology, phenotype, and molecular alterations of each entity.

 

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[247]

TÍTULO / TITLE:  - Identification of Serum MicroRNA-21 as a Biomarker for Chemosensitivity and Prognosis in Human Osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Int Med Res. 2012;40(6):2090-7.

AUTORES / AUTHORS:  - Yuan J; Chen L; Chen X; Sun W; Zhou X

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China.

RESUMEN / SUMMARY:  - OBJECTIVE: The aim of this study was to investigate the serum level of microRNA (miR)-21 in patients with osteosarcoma and its correlation with chemosensitivity  and prognosis. METHODS: miR-21 levels in sera from 65 patients with osteosarcoma  and 30 healthy controls were measured by real-time reverse transcription-polymerase chain reaction. Correlations between serum miR-21 and clinicopathological features in patients with osteosarcoma were determined. The prognostic significance of serum miR-21 was assessed using a Cox proportional hazards model. RESULTS: The serum level of miR-21 was significantly higher in patients with osteosarcoma than in control subjects. High serum miR-21 was significantly correlated with advanced Enneking stage and chemotherapeutic resistance. Univariate and multivariate analyses for overall survival showed that upregulation of serum miR-21 was an independent, unfavourable prognostic factor for patients with osteosarcoma (hazard ratio, 2.325). CONCLUSIONS: miR-21 might be a good candidate for a therapeutic target, and a potential biomarker for the prediction of chemotherapeutic sensitivity and prognosis in patients with osteosarcoma.

 

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[248]

TÍTULO / TITLE:  - Snail2 promotes osteosarcoma cell motility through remodelling of the actin cytoskeleton and regulates tumor development.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Lett. 2013 Jan 22. pii: S0304-3835(13)00059-1. doi: 10.1016/j.canlet.2013.01.027.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.canlet.2013.01.027

AUTORES / AUTHORS:  - Sharili AS; Allen S; Smith K; Price J; McGonnell IM

INSTITUCIÓN / INSTITUTION:  - Department of Comparative Biomedical Sciences, Royal Veterinary College, London,  UK.

RESUMEN / SUMMARY:  - The function of Snail2 in mesenchymal tumors is, to date unknown. Using knockdown and overexpression studies, we show that Snail2 regulates migration and invasion  of osteosarcoma cells. Knockdown resulted in significantly decreased motility, remodelling of the actin cytoskeleton, and loss of cellular protrusions. Over-expression increased motility, formation of actin-rich cellular protrusions, and altered expression of some non-canonical Wnt pathway components whilst decreasing expression of the adhesion molecule OB-cadherin. Unexpectedly, knockdown also resulted in significantly smaller tumors in an in vivo CAM assay.  Therefore Snail2 may be a potential therapeutic target for clinical intervention  of osteosarcoma.

 

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[249]

TÍTULO / TITLE:  - TNF-alpha upregulates macroautophagic processing of APP/beta-amyloid in a human rhabdomyosarcoma cell line.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurol Sci. 2013 Feb 15;325(1-2):103-7. doi: 10.1016/j.jns.2012.12.011. Epub 2013 Jan 5.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jns.2012.12.011

AUTORES / AUTHORS:  - Keller CW; Schmitz M; Munz C; Lunemann JD; Schmidt J

INSTITUCIÓN / INSTITUTION:  - Department of Neurology, University Medical Center Gottingen, Gottingen, Germany; Institute of Experimental Immunology, Department of Neuroinflammation, University of Zurich, Zurich, Switzerland.

RESUMEN / SUMMARY:  - Sporadic inclusion body myositis is a chronic progressive, inflammatory disorder  of the skeletal muscle. No effective treatment is available for this debilitating condition and the complex disease pathology is far from being understood. The major hallmark of the pathomechanisms is the co-occurrence of inflammatory as well as degenerative cascades including aggregates consisting of beta-amyloid within skeletal muscle fibers. Macroautophagy, a homeostatic process that shuttles cytoplasmic constituents into endosomal and lysosomal compartments, has  recently been shown to be upregulated via the proinflammatory cytokine TNF-alpha  in human skeletal muscle cells. In a human cell line from rhabdomyosarcoma as a model to study muscle cells, we here show that TNF-alpha-mediated upregulation of macroautophagy modulates APP and beta-amyloid load and can be blocked by inhibition of macroautophagy. Thus, macroautophagy may be a crucial mediator between inflammation and beta-amyloid-associated degeneration in skeletal muscle.

 

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[250]

TÍTULO / TITLE:  - Atypical Cutaneous Leiomyosarcoma with Skip-Lesion Behavior.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dermatol Surg. 2013 Jan 7. doi: 10.1111/dsu.12102.

            ●● Enlace al texto completo (gratuito o de pago) 1111/dsu.12102

AUTORES / AUTHORS:  - Feigenbaum L; Skinner D; Golda N

INSTITUCIÓN / INSTITUTION:  - School of Medicine, University of Missouri, Columbia, Missouri.

 

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[251]

TÍTULO / TITLE:  - Highly effective unconventional management in Aspergillosis of left maxillary sinus in an 11-year-old girl with rhabdomyosarcoma embryonale of the frontal sinus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Microbiol. 2012 Dec 14.

            ●● Enlace al texto completo (gratuito o de pago) 1099/jmm.0.044222-0

AUTORES / AUTHORS:  - Peregud-Pogorzelski J; Wawrykow P; Wozniak S; Zakowska A; Brodkiewicz A

INSTITUCIÓN / INSTITUTION:  - Pomeranian Medical University.

RESUMEN / SUMMARY:  - Invasive fungal infections are common causes of death in children treated for malignancies, and therefore present an important and growing clinical problem. Fungal invasion usually affects immunocompromised patients, but increased incidences are also associated with intensification of antineoplastic therapy and increased numbers of organ and bone marrow transplantations. Fungal infections in parameningeal and cerebral locations carry high risks of treatment failure. We present an 11-year-old female patient with rhabdomyosarcoma embryonale of the frontal sinuses with metastases to the neck lymph nodes, treated according to the CWS 2002 program for high-risk patients. Left maxillary sinus aspergillosis was diagnosed during chemotherapy following radiotherapy, and 56 days after surgical  excision of the tumor. Treatment included intravenous voriconazole 6 mg/kg body weight every 12 h for 2 weeks, followed by oral voriconazole 4 mg/kg body weight  twice daily for 6 months. Simultaneous excision of necrotic tissues from the nasal cavity, ethmoid bone, maxillary sinus and frontal recess was performed. The sinus was kept open for 3 weeks to allow voriconazole lavage every 12 h for 3 weeks. This unconventional treatment resulted in eradication of sinus aspergillosis and allowed intensive chemotherapy to be continued with no recurrence of aspergillosis.

 

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[252]

TÍTULO / TITLE:  - Leiomyosarcoma after hysteroscopic myomectomy: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Gynaecol Oncol. 2012;33(6):656-7.

AUTORES / AUTHORS:  - Carta G; Palermo P; Di Ramio R; De Lellis V; Carta A; Patacchiola F

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Sciences, University of L’Aquila, Italy. gaspare.carta@cc.univaq.it

RESUMEN / SUMMARY:  - OBJECTIVES: The aim of this study was to illustrate the importance of hysteroscopy in the evolution of mitotically active leiomyoma to leiomyosarcoma (LMS). Uterine sarcomas are rare tumors. The three microscopic criteria are: 1) the presence of coagulative tumor necrosis, 2) high mitotic index (exceeding 15 x 10 catabolite gene activator (CGA) and 3) occurrence of moderate to severe cytologic atypia. The authors report a case of a 52-year-old nulliparous woman with a LMS detected two months after a hysteroscopic resection of a mitotically active leiomyoma. After the first hysteroscopic resection the diagnosis was atypical leiomyoma with a mitotic index of two per ten high-power field (hpf) in  the absence of coagulation necrosis. After two months, a new myoma was detected and another hysteroscopic resection was performed: the microscopic diagnosis was  LMS and a total abdominal hysterectomy with bilateral salpingo-oophorectomy (BSO) was performed. CONCLUSION: The patient must undergo close clinical and instrumental follow-up procedures. Hysteroscopy plays an important role in the evaluation and evolution of both recurrent and de novo disease.

 

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[253]

TÍTULO / TITLE:  - Transnasal endoscopic piezoelectric-assisted removal of frontal sinus osteoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Laryngoscope. 2013 Jan 8. doi: 10.1002/lary.23728.

            ●● Enlace al texto completo (gratuito o de pago) 1002/lary.23728

AUTORES / AUTHORS:  - Gotlib T; Niemczyk K

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology, Medical University of Warsaw, Warsaw, Poland. tgotlib@wum.edu.pl.

 

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[254]

TÍTULO / TITLE:  - Mullerian carcinosarcoma arising in the cecum associated with florid vascular proliferation/glomeruloid microvascular proliferation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Gynecol Pathol. 2013 Jan;32(1):38-43. doi: 10.1097/PGP.0b013e318257df2a.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PGP.0b013e318257df2a

AUTORES / AUTHORS:  - Stewart CJ; Abeysuriya D; Kumarasinghe P; Salfinger S; Tan J

INSTITUCIÓN / INSTITUTION:  - Department of Histopathology, University of Western Australia, Perth, Western Australia, Australia. colin.stewart@health.wa.gov.au

RESUMEN / SUMMARY:  - Angiogenesis is required for tumor growth, and the degree of new vessel formation correlates with adverse prognosis in many types of malignancies. It has now been  appreciated that tumor-associated vasculature is heterogenous and sometimes includes a complex vasoformative process that has been termed florid vascular proliferation or glomeruloid microvascular proliferation. These vascular lesions  are most characteristic of high-grade gliomas and neuroendocrine tumors but are being increasingly recognized in other types of neoplasias as well. Herein we report a case of carcinosarcoma arising within the cecal wall of a 62-yr-old patient that exhibited florid vascular proliferation, particularly at the time of peritoneal recurrence. Recognition of these tumor-associated vasoformative lesions may be important in view of their adverse prognostic association and may  become therapeutically relevant considering the current developments in angiogenesis inhibitors.

 

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[255]

TÍTULO / TITLE:  - Simultaneous Pulmonary and Inferior Vena Cava Thromboembolism Secondary to Pelvic Osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Hematol Oncol. 2012 Dec 28.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MPH.0b013e3182707a1a

AUTORES / AUTHORS:  - Lin WC; Lin CH; Chao YH; Lin HC; Chen PY; Wu HP; Wu KH

INSTITUCIÓN / INSTITUTION:  - *Departments of Radiology #Pediatrics **Pathology daggerSchool of Medicine double daggerdouble daggerSchool of Chinese Medicine, China Medical University double daggerDepartments of Medical Imaging and Radiological Science section signChildren Education and Enterprise, Central Taiwan University of Science and Technology parallelDepartment of Pediatrics paragraph signSchool of Medicine, Chung Shan Medical University daggerdaggerDepartment of Pediatrics, Buddhist Tzu-Chi General Hospital, Taichung Branch, Taichung, Taiwan.

RESUMEN / SUMMARY:  - Thromboembolism presenting with malignancy is common in adults but rare in children. We describe the case of a 17-year-old boy admitted to our hospital with syncope. Computed tomography revealed thromboembolism in both the lungs. Magnetic resonance imaging found thromboembolism in the inferior vena cava and a large heterogeneous mass in the pelvis. Pelvic osteosarcoma was confirmed by computed tomography-guided biopsy. Despite intensive chemotherapy and local radiation, only transient response was noted, the tumor remaining unresectable. To our knowledge, this is the first reported case of simultaneous pulmonary and inferior vena cava thromboembolism secondary to pelvic osteosarcoma in children. We also emphasize syncope as a unique feature of pulmonary thromboembolism. Accordingly,  thromboembolism should be kept in mind as the first manifestation of occult malignancy, even in children.

 

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[256]

TÍTULO / TITLE:  - Adjuvant and Neoadjuvant Chemotherapy for Soft Tissue Sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Curr Med Chem. 2012 Dec 17.

AUTORES / AUTHORS:  - Maruzzo M; Rastrelli M; Lumachi F; Zagonel V; Basso U

INSTITUCIÓN / INSTITUTION:  - Medical Oncology 1, Istituto Oncologico Veneto (IOV), IRCCS, Via Gattamelata 64,  35128 Padova, Italy. umberto.basso@ioveneto.it.

RESUMEN / SUMMARY:  - Sarcomas of the soft tissue are a heterogeneous, rare and complex group of mesenchymal malignant tumors, accounting for less than 1% of all adult malignancies and about 10-15% of childhood cancer. Despite local disease control  obtained with surgery and pre- or postoperative radiotherapy, roughly one half of patients with high-grade tumors experience metastatic disease. The adjunction of  chemotherapy, either before or after resection, is not currently viewed as standard practice due to the lack of reproducible impact on survival. The 1997 SMAC meta-analysis based on individual data from randomized studies confirmed a significant impact of adjuvant chemotherapy on both local and metastatic relapse, without any significant benefit on survival. Further meta-analyses demonstrated a significant benefit also in overall survival. Yet, the latest adjuvant EORTC trial was disappointedly negative. To date, adjuvant chemotherapy may be recommended as a reasonable option for the high-risk individual patient who should be well informed on the possible risks and benefits of treatment. Also the indications for neoadjuvant chemotherapy remain controversial. A local benefit may be gained, facilitating surgery, but data on survival are limited and affected by a strong patient selection bias. In order to improve our knowledge on sarcomas and to offer patients the best of current standards, we strongly recommend that all patients be referred to a sarcoma multidisciplinary group, under whose supervision they could receive the correct combined-modality management as well as have access to new clinical trials appropriately stratified for risk and histological and/or molecular subtypes.

 

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[257]

TÍTULO / TITLE:  - The cucurbitacins E, D and I: Investigation of their cytotoxicity toward human chondrosarcoma SW 1353 cell line and their biotransformation in man liver.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Toxicol Lett. 2013 Feb 4;216(2-3):189-99. doi: 10.1016/j.toxlet.2012.11.014. Epub 2012 Nov 27.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.toxlet.2012.11.014

AUTORES / AUTHORS:  - Abbas S; Vincourt JB; Habib L; Netter P; Greige-Gerges H; Magdalou J

INSTITUCIÓN / INSTITUTION:  - UMR 7561 CNRS-Universite Lorraine, School of Medicine, 9 Avenue de la foret de Haye, BP 184, F-54505 Vandoeuvre-les-Nancy, Cedex, France. Electronic address: suziabbas@yahoo.com.

RESUMEN / SUMMARY:  - Cucurbitacins are a class of natural compounds known for their numerous potential pharmacological effects. The purpose of this work was to compare the cytotoxicity of three cucurbitacins I, D, E on the chondrosarcoma SW 1353 cancer cell line and to investigate their biotransformation in man. Cucurbitacins I and D showed a very strong cytotoxicity, which was higher than that of cytochalasin D, used as a drug reference. Almost 100% of the cells were apoptotic as observed by DNA fragmentation (TUNEL assay) after 12h with cucurbitacins I and D (1muM) and cucurbitacin E (10muM). In terms of IC(50) values, cucurbitacins I and E presented a higher toxicity compared to that of cucurbitacin D (MTT assay). Cucurbitacin E was readily hydrolyzed by human hepatic microsomes, leading to cucurbitacin I (K(m) 22muM, V(max) 571nmol/mg proteins/min). On the other hand, the three cucurbitacins were hydroxylated at a very low extent, but they were sulfated and glucuronidated. In terms of V(max)/K(m), the cucurbitacin E was the  best substrate of UDP-glucuronosyltransferases. This study shows that cucurbitacins I, D and E present a potent cytotoxic activity toward the chondrosarcoma SW 1353 cell line and are metabolized as sulfate and glucuronide conjugates.

 

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[258]

TÍTULO / TITLE:  - Myxoid Solitary Fibrous Tumor: A Study of Three Cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Pathol. 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1066896912470166

AUTORES / AUTHORS:  - Dantey K; Cooper K

RESUMEN / SUMMARY:  - Limited myxoid areas are usually encountered in solitary fibrous tumor (SFT), but SFT with abundant myxoid stroma has only been reported occasionally. Myxoid SFT is defined as having myxoid changes in 50% or more of the tumor. We review the literature on myxoid SFT and add 3 new cases to those previously described. Microscopically, the lesions were composed of spindle cells arranged in a haphazard or storiform pattern in a cellular and hypocellular myxoid background with thin-walled “staghorn” branching vessels. Atypical features (necrosis, hypercellularity, or increased mitotic figures) were not identified. All cases were positive for CD34 and CD99 and had a benign course with a follow-up ranging  from 3 to 70 months. Our review suggests that like classical SFT, myxoid SFT is associated with an indolent clinical course and favorable prognosis. Their recognition is crucial to distinguish a variety of myxoid spindle cell neoplasms  with different prognoses and treatment options.

 

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[259]

TÍTULO / TITLE:  - Primary pulmonary artery myxoma: a rare case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Imaging. 2013 Jan-Feb;37(1):159-62. doi: 10.1016/j.clinimag.2012.04.015. Epub 2012 Jun 8.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clinimag.2012.04.015

AUTORES / AUTHORS:  - Mai XL; Fan HJ; Li BX; Zhu B

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China. m_mxl@163.com

RESUMEN / SUMMARY:  - Pulmonary embolism is the most frequent diagnosis for a filling defect in the pulmonary artery, but a tumor in the arteriae pulmonalis should be contained in the differential diagnosis. Primary pulmonary artery myxoma is extremely rare, and only a few cases have been reported. The early diagnosis of this disease is difficult, but it is feasible with modern radiographic methods, which play an important role in the presentation of the origin and extension of the tumor. Here, we review one case with computed tomographic (CT) and pulmonary CT angiographic findings to emphasize the significance of the imaging method in its  diagnosis.

 

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[260]

TÍTULO / TITLE:  - Pathogenesis and malignant transformation of adenomyosis (Review).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Rep. 2013 Mar;29(3):861-7. doi: 10.3892/or.2012.2184. Epub 2012 Dec 13.

            ●● Enlace al texto completo (gratuito o de pago) 3892/or.2012.2184

AUTORES / AUTHORS:  - Koike N; Tsunemi T; Uekuri C; Akasaka J; Ito F; Shigemitsu A; Kobayashi H

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634-8522, Japan.

RESUMEN / SUMMARY:  - The aim of our review was to identify the current information with regard to the  pathogenesis and malignant transformation of adenomyosis. The current literature  was reviewed by searching MEDLINE/PubMed, using the following keywords: adenomyosis, myometrium, stromal cells, malignant transformation, pathogenesis, etiology, genome-wide and microarray. Early signs of the development of adenomyosis are considered to be the penetration of stromal cells into the inner  layer of the myometrium. Adenomyosis smooth muscle cells are developed, possibly, through a remodeling pathway via reactivation of coelomic epithelial cells as a result of estrogen-induced epithelial mesenchymal transition. Smooth muscle cell  hyperplasia and hypertrophy are a reflection of a reaction of the surrounding tissue. The development of adenocarcinoma arising from adenomyosis is a relatively rare occurrence. In our literature review, to date, 44 cases of malignant tumors arising from adenomyosis have been documented. Studies reporting results of genetic abnormalities, epigenetic changes, monoclonal expansion, mutational analysis and the inactivation of specific tumor suppressor genes are very few in this field. In conclusion, adenomyosis can be a precursor of some carcinomas. The exact molecular mechanisms that lead to the malignant transformation are poorly understood.

 

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[261]

TÍTULO / TITLE:  - Gingival swelling and pleural effusion: non-leukemic Myeloid Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Haematol. 2013 Jan 22. doi: 10.1111/ejh.12077.

            ●● Enlace al texto completo (gratuito o de pago) 1111/ejh.12077

AUTORES / AUTHORS:  - Guastafierro S; Falcone U; Colella G

INSTITUCIÓN / INSTITUTION:  - Division of Hematology, Second University of Naples, Naples, Italy.

RESUMEN / SUMMARY:  - A 56-year-old woman presented with dyspnea and a large swelling in the upper vestibular region (Figure 1 A), appeared 6 weeks before and continuing to grow up. Physical examination suggested pleural effusion, subsequently confirmed by chest X-ray (Figure 1 B). Complete blood cell count and biochemistry values were  all within normal ranges, excepting for LDH (2620 IU/L) and beta(2) -microglobulin (9.4 mg/L). © 2013 John Wiley & Sons A/S.

 

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[262]

TÍTULO / TITLE:  - Fibrous dysplasia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Pathol Lab Med. 2013 Jan;137(1):134-8. doi: 10.5858/arpa.2012.0013-RS.

            ●● Enlace al texto completo (gratuito o de pago) 5858/arpa.2012.0013-RS

AUTORES / AUTHORS:  - Riddle ND; Bui MM

INSTITUCIÓN / INSTITUTION:  - From the Department of Pathology and Laboratory Medicine, Pennsylvania Hospital,  Philadelphia (Dr Riddle); and the Department of Anatomic Pathology, Moffitt Cancer Center Hospital, Tampa, Florida (Dr Bui).

RESUMEN / SUMMARY:  - Fibrous dysplasia is an uncommon bone disease. The diagnosis is usually not difficult, given the symptoms, radiology, and histology. The gene involved is the alpha subunit of the G-protein receptor. Recent innovation in molecular pathology has helped us understand the mechanism of disease pathogenesis. The treatment of  fibrous dysplasia is limited to maintenance of maximum bone density. Surgical reinforcement is used to treat bowing deformities and fractures as they occur. Malignant transformation of fibrous dysplasia is rare. Currently, there is no therapy for preventing the disease from advancing or for malignant transformation.

 

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[263]

TÍTULO / TITLE:  - Sarcomatoid carcinoma of the remnant stomach: report of a case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Surg Today. 2012 Dec 14.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00595-012-0402-7

AUTORES / AUTHORS:  - Sato A; Oki E; Kohso H; Endo Y; Uchida H; Hiroshige S; Ishida M; Saito G; Matsumoto T; Takeuchi H; Kusumoto T; Yoshikawa Y; Muto Y

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, National Hospital Organization Beppu Medical Center, 1473  Uchikamado, Beppu, Oita, 874-0011, Japan, aikosato@med.oita-u.ac.jp.

RESUMEN / SUMMARY:  - We herein report a case of sarcomatoid carcinoma that developed in a remnant stomach. A 76-year-old male with a history of distal gastrectomy for a duodenal ulcer 28 years earlier underwent investigation for a tumor in the remnant stomach. An endoscopic survey showed a round elevated tumor measuring 6 cm in diameter, and a biopsy specimen suggested carcinosarcoma. A total gastrectomy of  the remnant stomach was performed, and the excised tumor was identified to be a malignant neoplasm consisting of both carcinomatous and sarcomatous components. A diagnosis of sarcomatoid carcinoma was made since the epithelial markers were positive even in the mesenchymal elements of the tumor. To our knowledge, only 4  cases of sarcomatoid carcinoma of the stomach have been reported in the English literature so far.

 

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[264]

TÍTULO / TITLE:  - Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-kappaB pathway.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Rep. 2013 Feb;29(2):571-8. doi: 10.3892/or.2012.2165. Epub 2012 Dec 4.

            ●● Enlace al texto completo (gratuito o de pago) 3892/or.2012.2165

AUTORES / AUTHORS:  - Peng L; Liu A; Shen Y; Xu HZ; Yang SZ; Ying XZ; Liao W; Liu HX; Lin ZQ; Chen QY; Cheng SW; Shen WD

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, PR China.

RESUMEN / SUMMARY:  - Thymoquinone (TQ), the predominant bioactive constituent derived from the medicinal spice Nigella sativa (also known as black cumin), has been applied for  medical purposes for more than 2,000 years. Recent studies reported that thymoquinone exhibited inhibitory effects on the cell proliferation of several cancer cell lines. This study was performed to investigate the antitumor and anti-angiogenic effects of thymoquinone on osteosarcoma in vitro and in vivo. Our results showed that thymoquinone induced a higher percentage of growth inhibition and apoptosis in the human osteosarcoma cell line SaOS-2 compared to that of control, and thymoquinone significantly blocked human umbilical vein endothelial  cell (HUVEC) tube formation in a dose-dependent manner. To investigate the possible mechanisms involved in these events, we performed electrophoretic mobility shift assay (EMSA) and western blot analysis, and found that thymoquinone significantly downregulated NF-kappaB DNA-binding activity, XIAP, survivin and VEGF in SaOS-2 cells. Moreover, the expression of cleaved caspase-3  and Smac were upregulated in SaOS-2 cells after treatment with thymoquinone. In addition to these in vitro results, we also found that thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing NF-kappaB and its regulated molecules. Collectively, our results demonstrate that thymoquinone effectively inhibits tumor growth and angiogenesis both in vitro and in vivo. Moreover, inhibition of NF-kappaB and downstream effector molecules is a possible underlying mechanism of the antitumor and anti-angiogenic activity of thymoquinone in osteosarcoma.

 

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[265]

TÍTULO / TITLE:  - Angiomyolipoma with minimal fat: Differentiation from papillary renal cell carcinoma by helical CT.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Radiol. 2013 Jan 12. pii: S0009-9260(12)00476-X. doi: 10.1016/j.crad.2012.08.028.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.crad.2012.08.028

AUTORES / AUTHORS:  - Zhang YY; Luo S; Liu Y; Xu RT

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, China; Department of Radiology, Liaoning Tumor Hospital, Shenyang, China.

RESUMEN / SUMMARY:  - AIM: To evaluate whether helical computed tomography (CT) images can be used to differentiate angiomyolipomas (AMLs) with minimal fat from papillary renal cell carcinomas (PRCCs) based on their morphological characteristics and enhancement features. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board. Informed consent was waived. Forty-four patients (21  with AMLs with minimal fat and 23 with PRCCs) who underwent enhanced helical CT before total or partial nephrectomy were included. Two radiologists, who were blinded to the histopathology results, read the CT images and recorded the attenuation value, morphological characteristics, and enhancement features of the tumours, which were subsequently evaluated. An independent samples t-test, chi(2) test, and rank sum test were performed between the tumours. The predictive value  of a CT finding was determined by multivariate logistic regression analysis. RESULTS: AML with minimal fat had an apparent female prevalence (p < 0.01). Intra-tumoural vessels were noted in 11 cases of AML with minimal fat and three PRCC cases (p < 0.01). The unenhanced attenuation characteristic was significantly different between the two diseases (p < 0.001). The absolute attenuation values (AAVs) and the corrected attenuation values (CAVs) of the AML  with minimal fat group of unenhanced and two phases of enhanced images were greater compared with that of the PRCC group (p < 0.05). After contrast medium injection, the tumour enhancement value (TEV) of the AML with minimal fat group in the corticomedullary phase was greater than that of the PRCC group (p < 0.01). Most cases of both tumour types demonstrated early enhancement characteristics; the enhancement value of the AML with minimal fat group was greater compared with that of the PRCC group (p < 0.01). The unenhanced attenuation characteristic, intra-tumoural vessels, and CAVs of unenhanced and early excretory phase scans were valuable parameters to differentiate between AML with minimal fat and PRCC tumours by multivariate logistic regression analysis (p < 0.05 for all). CONCLUSION: The unenhanced attenuation characteristic, intra-tumoural vessels, and the attenuation values of unenhanced and early excretory phase scans are valuable parameters in differentiating AML with minimal fat from PRCC at CT.

 

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[266]

TÍTULO / TITLE:  - Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Int. 2012 Dec;62(12):823-6. doi: 10.1111/pin.12022.

            ●● Enlace al texto completo (gratuito o de pago) 1111/pin.12022

AUTORES / AUTHORS:  - Nakayama R; Miura Y; Ogino J; Susa M; Watanabe I; Horiuchi K; Anazawa U; Toyama Y; Morioka H; Mukai M; Hasegawa T

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.

RESUMEN / SUMMARY:  - Mesenchymal chondrosarcoma (MC) is an extremely rare subtype of chondrosarcoma. A tumor specific fusion gene, HEY1-NCOA2 fusion, was recently identified in this tumor. The finding raises the possibility that the diagnosis of MC can be improved by examining the fusion gene. In the present study, we aimed to evaluate the efficacy of fluorescence in situ hybridization (FISH) in detecting HEY1-NCOA2 fusion for the diagnosis of MC. Specimens from 10 patients diagnosed with MC were used for the study. Dual-color FISH was performed using two different probes that specifically hybridize to HEY1 and NCOA2, respectively. Fusion signals were identified in all but two specimens, in which no signal was detected, presumably  because of inadequate sample preparation. In accordance with results of a previous study, FISH analysis was highly sensitive in detecting HEY1-NCOA2 fusion in adequately prepared MC samples. The current study adds further support for the use of HEY1-NCOA2 fusion as a valid diagnostic marker for MC.

 

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[267]

TÍTULO / TITLE:  - Axillary calcifying fibrous tumor (CFT) in an 8 year old girl.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Surg. 2012 Dec;47(12):2341-4. doi: 10.1016/j.jpedsurg.2012.10.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpedsurg.2012.10.008

AUTORES / AUTHORS:  - Cao KX; Rosenberg AE; Hakim J; Masiakos PT

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

RESUMEN / SUMMARY:  - Calcifying fibrous tumors (CFTs) are benign soft tissue masses that can occur at  many sites. This case report outlines the diagnostic workup for this rare, fast-growing, solitary mass in an otherwise healthy 8 year old patient. We also describe the radiographic and pathological characteristics unique to this lesion.

 

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[268]

TÍTULO / TITLE:  - Fibrous soft tissue tumors: Factors predictive of recurrence.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Surg. 2013 Jan;48(1):56-61. doi: 10.1016/j.jpedsurg.2012.10.018.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpedsurg.2012.10.018

AUTORES / AUTHORS:  - Aldrink JH; Nicol K; Wang W; Teich S

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Division of Pediatric Surgery, The Ohio State University College of Medicine and Nationwide Children’s Hospital, Columbus, OH, USA. Electronic address: Jennifer.aldrink@nationwidechildrens.org.

RESUMEN / SUMMARY:  - BACKGROUND/PURPOSE: Fibrous soft tissue tumors (FSTT) of infancy and childhood present a challenge to surgeons due to ambiguous histological interpretation, propensity for local recurrence, and uncertainty regarding appropriate therapy. METHODS: Records were reviewed for patients diagnosed and treated for FSTT at our institution from 1992 to 2010. Data included demographics, tumor location, operative treatment, histopathology, margin status, mitotic index, and recurrence. RESULTS: Eighty-six patients underwent treatment of FSTT. Mean follow-up time was 62months (range 1 to 201months). There were 11 recurrences (13%), with a mean time to recurrence of 23months. Extremity and digital lesions  were most likely to recur with 21% of such lesions recurring compared to 7% of lesions located elsewhere. Recurrences were seen more frequently in older children. Despite the presence of positive margins in 92% of cases, margin status, histopathology, and mitotic index were not significant predictors of recurrence. CONCLUSIONS: Digital and extremity fibrous soft tissue tumors and tumors of older children have an increased risk for local recurrence. Margin status did not predict recurrence rates in this series. While the surgical goal is to obtain complete local resection with clear margins, this may be challenging in particular locations and may not ultimately impact recurrence.

 

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[269]

TÍTULO / TITLE:  - Surgical Management of Incidental Renal Tumor during Excision of Retroperitoneal  Liposarcoma and Osteogenic Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am Surg. 2013 Feb;79(2):88-90.

AUTORES / AUTHORS:  - Frank RM; Velasco JM

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA.

 

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[270]

TÍTULO / TITLE:  - Through the looking glass: primary epithelioid angiosarcoma in the left atrium, a unique site for a rare malignancy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - APMIS. 2013 Jan 18. doi: 10.1111/apm.12036.

            ●● Enlace al texto completo (gratuito o de pago) 1111/apm.12036

AUTORES / AUTHORS:  - Hynes SO; Attah CB; Ingoldsby H; Kolcow W; Macneill B; Veerasingam D; Orosz Z

INSTITUCIÓN / INSTITUTION:  - Departments of Histopathology, Galway University Hospitals, Ireland.

RESUMEN / SUMMARY:  - Malignant cardiac tumours occurring on the left side are vanishingly rare entities. We describe a case of a 73-year-old male who underwent surgery for a left-sided cardiac tumour following initial presentation with transient ischaemic attacks. In addition to the unusual presentation and subsequent metastatic pattern to the femur, the tumour’s pathological diagnosis was that of an epithelioid variant of an angiosarcoma which has not been previously described in this anatomical location.

 

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[271]

TÍTULO / TITLE:  - Autoclaved autologous bone graft for orbital reconstruction for recurrent temporal bone orbital osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniofac Surg. 2013 Jan;24(1):e59-62. doi: 10.1097/SCS.0b013e31827003ba.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SCS.0b013e31827003ba

AUTORES / AUTHORS:  - Shah JM; Wong A; Lim TC; Lim J; Mun LK; Ning C; Petersson BF; Sundar G

INSTITUCIÓN / INSTITUTION:  - From the *Department of Ophthalmology; daggerDepartment of Hematology-Oncology; double daggerDepartment of Plastic, Reconstructive and Aesthetic Surgery,Department of Surgery section signDepartment of Radiation Oncology, National University Cancer Institute, parallelDepartment of Neurosurgery, Department of Surgery; and paragraph signDepartment of Pathology, National University Hospital, National University Health System, Singapore, Singapore.

RESUMEN / SUMMARY:  - ABSTRACT: Post-tumor excision and reconstruction of the craniofacial region is a  complex and technically demanding process due to its proximity to numerous vital  structures and irregularly shaped bony tissue. As such, novel methods are needed  when reconstruction of irregularly shaped structures is necessary. Autoclaving of autologous bone grafts is an established practice in orthopedic and neurosurgical practice, but has only been described twice previously for orbital reconstruction. We performed grafting of an autoclaved autologous bone segment as part of surgery on a 30-year-old man to treat his recurrent temporal osteosarcoma with orbital involvement, which is rare. In addition, we went on to highlight key differences between bone autoclaving and pasteurization, an alternative heat treatment technique, for orbital reconstruction post-tumor excision. Although he  suffered a second recurrence 8 months later, there was no evidence of recurrence  in the autoclaved bone. To treat his second recurrence, he subsequently underwent a modified eyelid-conjunctiva sparing orbital exenteration, also an uncommonly performed procedure. Also, we subsequently examined the novel technique of a lid-sparing and conjunctiva-sparing orbital exenteration and its benefits. He continues to remain under follow-up.

 

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[272]

TÍTULO / TITLE:  - Radiofrequency Ablation of Large Renal Angiomyolipoma: Median-Term Follow-Up.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cardiovasc Intervent Radiol. 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00270-012-0483-0

AUTORES / AUTHORS:  - Gregory SM; Anderson CJ; Patel U

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, St. George’s Hospital and Medical School, Blackshaw Road, London, SW17 0QT, UK, drstephengregory@gmail.com.

RESUMEN / SUMMARY:  - PURPOSE: To study the feasibility of percutaneous radiofrequency ablation (RFA) of large angiomyolipomas (AMLs) using saline-cooled electrodes. MATERIALS AND METHODS: Institutional Review Board approval for the study was received. Four patients (all female, age range 33-67 years) with large AMLs (maximal axis 6.1-32.4 cm) not suitable for embolotherapy or surgery consented to a trial of RFA. Procedures were performed under computerized tomographic guidance using 14G  saline-infused electrodes. Two ablations (diameter 4-7 cm) were undertaken in each patient. Variables studied were technical success, treatment safety, alteration of tumor consistency, tumor size, effect on renal function, and medium-term freedom from haemorrhage. RESULTS: All four patients underwent successful RFA without any intraprocedural complications. There has been no haemorrhage, or new renal specific symptom, during a minimum 48-month period, and normal renal function has been normal. On follow-up radiological imaging, the tumors have become fattier with involution of the soft-tissue elements (soft tissue-to-total tumor ratio decreased mean [range] of 0.26 [0.14-0.48] to 0.17 [0.04-0.34] U; p = 0.04 [paired Student t test]). Further evidence of treatment effect was the development of a capsule around the ablation zone, but there was no change in overall tumor volume (mean [range] 1,120 [118-2,845] to 1150 [90-3,013] ml; p = 1 [paired Student t test]). CONCLUSION: RFA of large AMLs is technically feasible using saline-infused electrodes. The soft-tissue elements decreased in volume; the tumors become fattier; and there has been no renal haemorrhage during a 48-month period.

 

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[273]

TÍTULO / TITLE:  - Progesterone Action in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Endocr Rev. 2013 Jan 9.

            ●● Enlace al texto completo (gratuito o de pago) 1210/er.2012-1043

AUTORES / AUTHORS:  - Kim JJ; Kurita T; Bulun SE

INSTITUCIÓN / INSTITUTION:  - Division of Reproductive Biology Research, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611.

RESUMEN / SUMMARY:  - Progesterone receptor (PR) mediates the actions of the ovarian steroid progesterone, which together with estradiol regulates gonadotropin secretion, prepares the endometrium for implantation, maintains pregnancy, and differentiates breast tissue. Separation of estrogen and progesterone actions in  hormone-responsive tissues remains a challenge. Pathologies of the uterus and breast, including endometrial cancer, endometriosis, uterine fibroids, and breast cancer, are highly associated with estrogen, considered to be the mitogenic factor. Emerging evidence supports distinct roles of progesterone and its influence on the pathogenesis of these diseases. Progesterone antagonizes estrogen-driven growth in the endometrium, and insufficient progesterone action strikingly increases the risk of endometrial cancer. In endometriosis, eutopic and ectopic tissues do not respond sufficiently to progesterone and are considered to be progesterone-resistant, which contributes to proliferation and survival. In uterine fibroids, progesterone promotes growth by increasing proliferation, cellular hypertrophy, and deposition of extracellular matrix. In normal mammary tissue and breast cancer, progesterone is pro-proliferative and carcinogenic. A key difference between these tissues that could explain the diverse effects of progesterone is the paracrine interactions of PR-expressing stroma and epithelium. Normal endometrium is a mucosa containing large quantities of distinct stromal cells with abundant PR, which influences epithelial cell proliferation and differentiation and protects against carcinogenic transformation. In contrast, the primary target cells of progesterone in the breast and fibroids are the mammary epithelial cells and the leiomyoma cells, which lack specifically organized stromal components with significant PR expression. This review provides a unifying perspective for the diverse effects of progesterone across human tissues and diseases.

 

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[274]

TÍTULO / TITLE:  - Sarcomatoid non-small cell lung cancer responding to sunitinib.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Clin Pharmacol Ther. 2013 Jan;51(1):87-8.

AUTORES / AUTHORS:  - Schultheis B; Kummer G; Strumberg D

INSTITUCIÓN / INSTITUTION:  - Department of Hematology and Oncology, Marienhospital Herne, Ruhr University Bochum, Germany.

 

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[275]

TÍTULO / TITLE:  - Myxoma blush with contrast echocardiography.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Cardiol. 2012 Dec 2. pii: S0167-5273(12)01584-7. doi: 10.1016/j.ijcard.2012.11.101.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijcard.2012.11.101

AUTORES / AUTHORS:  - Yousaf H; Patel M; Khandheria BK; Paterick TE; Kleinman L; Khitha J; Ammar KA

INSTITUCIÓN / INSTITUTION:  - ThedaCare Medical Center, Neenah, WI, USA.

 

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[276]

TÍTULO / TITLE:  - 18F-Fluorodeoxyglucose Imaging of the Primary Breast Leiomyosarcoma and Follow-Up Lung Metastasis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e31826c0d0c

AUTORES / AUTHORS:  - Pai M; Yoon SN

INSTITUCIÓN / INSTITUTION:  - From the *Department of Nuclear Medicine, Myongji Hospital, Kwandong University College of Medicine, Goyang; and daggerDepartment of Nuclear Medicine, Cheil General Hospital, Women Cancer Center, Kwandong University College of Medicine, Seoul, Republic of Korea.

RESUMEN / SUMMARY:  - ABSTRACT: A 46-year-old woman presented with a large left breast mass. FDG PET/CT demonstrated a large left breast mass (SUV = 28). Preoperative biopsy showed malignant sarcoma. Modified radical mastectomy was performed. Immunohistochemical analysis using h-caldesmon and smooth muscle actin staining established the diagnosis of primary breast leiomyosarcoma. Despite intensive chemotherapy, 3-month follow-up PET/CT revealed a large lung metastasis suggesting aggressiveness and poor response to chemotherapy. Primary leiomyosarcoma of the breast is extremely rare and difficult to diagnose before excisional surgery because of the need for immunohistochemical staining to confirm the diagnosis.

 

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[277]

TÍTULO / TITLE:  - Osteoblastoma of the Mandible Mimicking Osteosarcoma in FDG PET/CT Imaging.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Feb;38(2):143-4. doi: 10.1097/RLU.0b013e318279f131.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e318279f131

AUTORES / AUTHORS:  - Strobel K; Merwald M; Huellner M; Zenklusen HR; Kuttenberger J

INSTITUCIÓN / INSTITUTION:  - From the *Department of Nuclear Medicine and Radiology, daggerDepartment of Oral  and Maxillofacial Surgery, and double daggerDepartment of Pathology, Cantonal Hospital Lucerne, Lucerne, Switzerland.

RESUMEN / SUMMARY:  - ABSTRACT: Osteoblastomas are rare tumors accounting for approximately 1% of all primary bone tumors. We report a case of osteoblastoma of the mandible with high  FDG uptake. Initially, this lesion was judged as an osteosarcoma. Osteoblastomas  are benign slow-growing tumors. High-resolution thin-slice CT images of the lesion as part of the PET/CT study help to characterize its morphology and extension, thus facilitating biopsy planning and resection. Approximately 25% of  osteoblastomas initially have the imaging appearance of a malignant tumor. In our case, complete resection of the lesion followed by reconstruction with a bone graft was performed.

 

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[278]

TÍTULO / TITLE:  - Proximal-type epithelioid sarcoma of the scrotum: 18F-FDG PET/CT imaging.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Jan;38(1):e45-7. doi: 10.1097/RLU.0b013e31824853db.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e31824853db

AUTORES / AUTHORS:  - Nguyen VX; Nguyen BD

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Mayo Clinic, Scottsdale, AZ 85259, USA. vnguy01@gmail.com

RESUMEN / SUMMARY:  - Proximal-type epithelioid sarcoma is an uncommon but aggressive soft-tissue malignancy involving proximal body parts especially perineum and genitalia of adult patients. This entity is a variant form of the conventional epithelioid sarcoma, which is frequently encountered at extremities of adolescents or young adults. The authors present a case of proximal-type epithelioid sarcoma of the scrotum with comprehensive staging and monitoring with PET/CT.

 

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[279]

TÍTULO / TITLE:  - Spontaneous massive hemoperitoneum: an atypical presentation of gastrointestinal  stromal tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am Surg. 2013 Feb;79(2):98-9.

AUTORES / AUTHORS:  - Sucandy I; Indeck MC

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Abington Memorial Hospital, Abington, Pennsylvania, USA.

 

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[280]

TÍTULO / TITLE:  - Intranodal palisaded myofibroblastoma: a new entity of axillary tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am Surg. 2013 Jan;79(1):19-21.

AUTORES / AUTHORS:  - Bhullar JS; Herschman BR; Dubay L

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Providence Hospital and Medical Centers, Southfield, Michigan, USA.

 

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[281]

TÍTULO / TITLE:  - Malignant fibrous histiocytoma of the diaphragm.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am Surg. 2013 Jan;79(1):12-3.

AUTORES / AUTHORS:  - Perelas A; Papantoni E; Sakorafas GH; Vassileiou P; Arkadopoulos N; Smyrniotis V

INSTITUCIÓN / INSTITUTION:  - 4th Department of Surgery, Athens University, Medical School, ATTIKON University  Hospital, Athens, Greece.

 

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[282]

TÍTULO / TITLE:  - Basal Cell Carcinoma With Osteosarcomatous Component.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Dermatopathol. 2012 Dec 6.

            ●● Enlace al texto completo (gratuito o de pago) 1097/DAD.0b013e31826b352b

AUTORES / AUTHORS:  - Tse JY; Pawlak AC; Boussahmain C; Routhier CA; Dias-Santagata D; Kalomiris D; Hoang MP

INSTITUCIÓN / INSTITUTION:  - *Harvard Medical School, Boston, MA daggerDepartment of Pathology, Massachusetts  General Hospital, Boston, MA double daggerDermatopathology, Advanced Dermatology, Delray Beach, FL.

RESUMEN / SUMMARY:  - ABSTRACT:: Sarcomatoid carcinoma or carcinosarcomas of the skin are rare. Basal cell carcinoma (BCC) with osteosarcomatous differentiation is the second most common sarcomatoid carcinoma of the skin, following squamous cell carcinoma with  heterologous mesenchymal differentiation. There are only 11 cases of BCC with osteosarcomatous component reported in the literature, with limited documented molecular analyses. The authors report the clinical and histological features of  2 cases with molecular analyses for recurrent mutations in 17 cancer genes. In both cases, the epithelial or BCC component was positive for BerEP4 and high-molecular weight cytokeratin, whereas the sarcomatous component was negative for both markers. Mutational analyses revealed TP53 mutation in 1 case with p53 expression noted in both components. The other case was negative for both p53 expression and TP53 mutation.

 

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[283]

TÍTULO / TITLE:  - Superficial paramucosal clear cell sarcoma of the soft parts resembling melanoma  in a 13-year-old boy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cutan Pathol. 2013 Feb;40(2):265-8. doi: 10.1111/cup.12058. Epub 2012 Dec 10.

            ●● Enlace al texto completo (gratuito o de pago) 1111/cup.12058

AUTORES / AUTHORS:  - Sidiropoulos M; Busam K; Guitart J; Laskin WB; Wagner AM; Gerami P

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, Feinberg School of Medicine, Northwestern University,  Chicago, IL, USA.

RESUMEN / SUMMARY:  - Clear cell sarcoma (CCS) of tendons and aponeuroses, also known as melanoma of soft parts, represents an aggressive rare malignancy that is characterized by a nested or fascicular pattern of spindled cells and a pathognomonic reciprocal translocation, t(12;22)(q13;q12), that results in the fusion of EWSR1 and ATF1 genes. Numerous recent studies have recognized the importance of a cutaneous CCS  variant that can mimic a broad spectrum of entities, including spindle cell melanoma, spindle cell squamous carcinoma, cutaneous leiomyosarcoma and atypical  fibroxanthoma. We report a case of a 13-year-old boy with cutaneous CCS who presented with a few months history of an asymptomatic papule on the lower lip that was suggestive of a mucocele. Biopsy of the lesion showed a wedge shaped neoplasm arranged in nests and fascicles of epithelioid- to oval-shaped cells with pale cytoplasm, open chromatin and prominent nucleolus. The superficial component was closely opposed to the basal epithelium resembling the junctional nests of a melanocytic neoplasm. The process extended into and involved the striated muscle of the lip. The cells expressed S-100, CD99 and synaptophysin by  immunohistochemistry, and there was focal HMB-45 and microphthalmia transcription factor (MiTF) positivity as well. Fluorescence in situ hybridization confirmed the presence of the t(12;22) (ESWR1-ATF1) translocation.

 

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[284]

TÍTULO / TITLE:  - Gingival myeloid sarcoma in myelodysplastic syndrome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Support Care Cancer. 2013 Jan 4.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00520-012-1702-6

AUTORES / AUTHORS:  - Niscola P; Tendas A; Scaramucci L; Giovannini M; Cupelli L; Fratoni S; Perrotti A; de Fabritiis P

INSTITUCIÓN / INSTITUTION:  - Division of Haematology, Tor Vergata University, Sant’ Eugenio Hospital, Rome, Italy, pniscola@gmail.com.

 

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[285]

TÍTULO / TITLE:  - Gliosarcoma arising from an oligodendroglioma (oligosarcoma).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Neuropathol. 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 5414/NP300577

AUTORES / AUTHORS:  - Hiniker A; Hagenkord JM; Powers MP; Aghi MK; Prados MD; Perry A

RESUMEN / SUMMARY:  - Gliosarcoma, a biphasic tumor with both mesenchymal and glial elements, is typically considered a variant of astrocytoma (glioblastoma), WHO Grade IV. A 57-year-old man presented with altered mental status and was found to have a large right frontal mass. Biopsy and subsequent subtotal resection revealed a WHO Grade II oligodendroglioma with classic histological features, expression of IDH1 R132H mutant protein, and chromosome 1p19q co-deletion. Fifteen months later, the patient developed recurrent tumor composed of intersecting fascicles of spindled  cells with necrosis and a high mitotic index. The recurrent tumor stained for both mesenchymal and glial elements, consistent with the diagnosis of gliosarcoma, and showed retained IDH1 R132H expression. By FISH analysis, the gliosarcoma showed no evidence of 1p19q co-deletion. We performed SNP arrays and  detailed SNP analysis of both the oligodendroglioma and the gliosarcoma. This demonstrated loss of heterozygosity (LOH) of chromosomes 1 and 19 in the gliosarcoma with retention of the same full-length chromosomes 1 and 19 found intact in the oligodendroglioma. Not surprisingly, the gliosarcoma harbored multiple additional alterations, consistent with clonal evolution. There have been only rare reports of sarcomatous transformation of oligodendroglioma (“oligosarcoma”) and most were published prior to the development of modern genetic modalities. Here we present a case with detailed genetic evidence that suggests that mesenchymal metaplasia sarcomatous transformation is possible in classic oligodendrogliomas with 1p19q codeletions.

 

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[286]

TÍTULO / TITLE:  - The use of isolated limb infusion in limb threatening extremity sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Hyperthermia. 2013;29(1):1-7. doi: 10.3109/02656736.2012.740548. Epub 2012  Dec 3.

            ●● Enlace al texto completo (gratuito o de pago) 3109/02656736.2012.740548

AUTORES / AUTHORS:  - Vohra NA; Turaga KK; Gonzalez RJ; Conley A; Reed D; Bui MM; Cheong D; Letson DG; Zager JS

INSTITUCIÓN / INSTITUTION:  - Department of Sarcoma Oncology, Moffitt Cancer Center , Tampa , Florida.

RESUMEN / SUMMARY:  - This paper reports a single-institution experience with the use of isolated limb  infusion for limb salvage in locally advanced, unresectable, recurrent limb threatening soft tissue sarcomas. Background: Locally advanced, limb threatening  soft tissue sarcomas (STS) pose a significant treatment challenge. We report our  experience using isolated limb infusion (ILI) in patients with unresectable extremity STS. Methods: A total of 22 patients with extremity STS underwent 26 ILIs with melphalan and dactinomycin. Patient characteristics, intra-operative parameters and toxicity were recorded. Outcome measures included limb-salvage and in-field response rates. Results: Of the 19 lower and 7 upper extremity ILIs, Wieberdink grade III toxicity or less was observed in all. Median followup was 11 months. A total of 17 patients were evaluable at 3 months post-ILI with an overall response rate of 42%. Four (24%) had complete response (CR), three (18%)  partial response (PR), three (18%) stable disease (SD) and seven (41%) progressive disease (PD). Twelve of 17 (71%) underwent successful limb preservation at a median of 9 months post-ILI. Two (12%) were downstaged to resectable disease and remain showing no evidence of disease (NED) after surgery  at 30 and 22 months post-ILI. Conclusions: ILI is an attractive modality that provides regional disease control and limb preservation in patients with limb threatening sarcoma. Although short-term results appear encouraging, long-term follow-up is needed to fully assess the role of ILI in unresectable extremity STS.

 

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[287]

TÍTULO / TITLE:  - Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Semin Diagn Pathol. 2013 Feb;30(1):73-84. doi: 10.1053/j.semdp.2012.01.006.

            ●● Enlace al texto completo (gratuito o de pago) 1053/j.semdp.2012.01.006

AUTORES / AUTHORS:  - Fisher C

INSTITUCIÓN / INSTITUTION:  - Department of Histopathology, Royal Marsden Hospital, London, UK. Electronic address: cyrilfisher@gmail.com.

RESUMEN / SUMMARY:  - In recent years, a number of new soft tissue tumor entities have been described that occur in the skin only, or that also occur in other sites but form clinically and pathologically distinct subsets when arising in the skin and subcutaneous tissue. These include a variety of mesenchymal lineages and have variable malignant potential, although superficial malignant soft tissue tumors generally have a more favorable outcome than their more deeply located counterparts. This article reviews the clinical and pathologic features and differential diagnoses of atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelioma, myopericytoma, and perivascular epithelioid cell tumor.

 

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[288]

TÍTULO / TITLE:  - Atypical fibroxanthoma: a selective review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Semin Diagn Pathol. 2013 Feb;30(1):4-12. doi: 10.1053/j.semdp.2012.01.001.

            ●● Enlace al texto completo (gratuito o de pago) 1053/j.semdp.2012.01.001

AUTORES / AUTHORS:  - Gru AA; Santa Cruz DJ

INSTITUCIÓN / INSTITUTION:  - Department of Pathology & Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO.

RESUMEN / SUMMARY:  - The head and neck area has disproportionate number of cutaneous tumors given the  surface area, as compared with the rest of the body. Many of the tumors are related to chronic actinic damage and the most common by far are squamous and basal cell carcinomas. Atypical fibroxanthoma refers to a group of usually indolent cutaneous tumors that occur in older adults and are characterized histologically by a population of fusiform, epithelioid, and pleomorphic cells, numerous cells in mitosis, and intracytoplasmic lipidization in some cells. Numerous histologic variants have been described, including a clear-cell, desmoplastic or keloidal, granular, angiomatoid, hemosiderotic, and myxoid, among others. These tumors have a mesenchymal immunophenotype. Some authors believe that atypical fibroxanthoma is a dedifferentiated variant of squamous cell carcinoma. We present a review of this particular neoplasm with special emphasis  on the histomorphology, subtypes, immunophenotypic profile, and discussion of differential diagnosis.

 

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[289]

TÍTULO / TITLE:  - Kaposi’s sarcoma arising in a burn scar mimicking Marjolin’s ulcer.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Burns. 2012 Dec 27. pii: S0305-4179(12)00322-1. doi: 10.1016/j.burns.2012.10.003.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.burns.2012.10.003

AUTORES / AUTHORS:  - Monteiro D; Horta R; Eloy C; Silva P; Silva A

INSTITUCIÓN / INSTITUTION:  - Department of Plastic, Reconstructive and Maxillofacial Surgery, and Burn Unit, Centro Hospitalar Sao Joao, Porto Medical School, Alameda Professor Hernani Monteiro, 4202-451 Porto, Portugal. Electronic address: dimmonteiro@gmail.com.

 

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[290]

TÍTULO / TITLE:  - Emerging pathogenic mechanisms in human myxomatous mitral valve: lessons from past and novel data.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cardiovasc Pathol. 2012 Dec 20. pii: S1054-8807(12)00147-0. doi: 10.1016/j.carpath.2012.11.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.carpath.2012.11.001

AUTORES / AUTHORS:  - Hulin A; Deroanne C; Lambert C; Defraigne JO; Nusgens B; Radermecker M; Colige A

INSTITUCIÓN / INSTITUTION:  - Laboratory of Connective Tissues Biology, GIGA, University of Liege, Liege, Belgium.

RESUMEN / SUMMARY:  - INTRODUCTION: Myxomatous mitral valve is one of the most common heart valves diseases in human and has been well characterized at a functional and morphological level. Diseased valves are thickened as a result of extracellular matrix remodeling and proteoglycans accumulation accompanied by the disruption of the stratified structures of the leaflets. METHODS: Global transcriptomic analysis was used as a start-up to investigate potential pathogenic mechanisms involved in the development of the human idiopathic myxomatous mitral valve, which have been elusive for many years. RESULTS: These prospective analyses have  highlighted the potential role of apparently unrelated molecules in myxomatous mitral valve such as members of the transforming growth factor-beta superfamily,  aggrecanases of the “a disintegrin and metalloprotease with thrombospondin repeats I” family, and a weakening of the protection against oxidative stress. We have integrated, in this review, recent transcriptomic data from our laboratory [A. Hulin, C.F. Deroanne, C.A. Lambert, B. Dumont, V. Castronovo, J.O. Defraigne, et al. Metallothionein-dependent up-regulation of TGF-beta2 participates in the remodelling of the myxomatous mitral valve. Cardiovasc Res 2012;93:480-489] and from the publication of Sainger et al. [R. Sainger, J.B. Grau, E. Branchetti, P.  Poggio, W.F. Seefried, B.C. Field, et al. Human myxomatous mitral valve prolapse: role of bone morphogenetic protein 4 in valvular interstitial cell activation. J  Cell Physiol 2012;227:2595-2604] with existing literature and information issued  from the study of monogenic syndromes and animal models. CONCLUSION: Understanding cellular alterations and molecular mechanisms involved in myxomatous mitral valve should help at identifying relevant targets for future effective pharmacological therapy to prevent or reduce its progression.

 

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[291]

TÍTULO / TITLE:  - Endoscopic resection of co-existing severe dysplasia and a small esophageal leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastroenterol. 2013 Jan 7;19(1):137-40. doi: 10.3748/wjg.v19.i1.137.

            ●● Enlace al texto completo (gratuito o de pago) 3748/wjg.v19.i1.137

AUTORES / AUTHORS:  - Ahn SY; Jeon SW

INSTITUCIÓN / INSTITUTION:  - Sun Young Ahn, Seong Woo Jeon, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 700-721, South Korea.

RESUMEN / SUMMARY:  - Leiomyoma is the most common benign mesenchymal tumor of the esophagus. A small leiomyoma covered with endoscopically normal mucosa has a characteristic endoscopic ultrasonographic appearance, slow growth rate, and negligible risk of  malignant transformation; therefore the histology does not need to be proven. Synchronous tumors such as an epithelial tumor and small subepithelial tumor in the upper gastrointestinal tract are uncommon. We describe a case with a co-existing small leiomyoma and severe dysplasia in the esophagus which were completely resected by endoscopic mucosal resection.

 

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[292]

TÍTULO / TITLE:  - Large atrial thrombus at unusual site: masquerading atrial myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Thromb Thrombolysis. 2013 Jan 26.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11239-013-0866-3

AUTORES / AUTHORS:  - Singh Y; Kharge J; Ramegowda RT; Nanjappa MC

INSTITUCIÓN / INSTITUTION:  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India, dryadvinder@hotmail.com.

 

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[293]

TÍTULO / TITLE:  - Endonasal endoscopic management of juvenile nasopharyngeal angiofibroma without angiographic embolization.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Arch Otorhinolaryngol. 2012 Dec 28.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00405-012-2315-x

AUTORES / AUTHORS:  - El Sharkawy AA

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology, Mansoura University, Mansoura, Egypt, assersharkawy@yahoo.com.

RESUMEN / SUMMARY:  - The objective of the study was to present our experience with definitive endonasal endoscopic management of patients with Radkowski stage IA&B and IIA Juvenile nasopharyngeal angiofibroma (JNAs) without preoperative angiographic embolization. This was a retrospective study performed at tertiary referral center. 18 males with JNAs stage IA&B and II A according to Radkowski classification were included in this study. Their ages ranged from 14 to 23 years with a mean of 16.7 years. All patients were presented by nasal obstruction with  recurrent epistaxis in 15 patients. All the patients underwent computed tomography and magnetic resonance imaging to delineate the extent and location of the tumor. Neither angiography nor embolization was done for any patient preoperatively. An endonasal endoscopic technique was used for excision of the tumors in all patients. Complete removal of the tumor was achieved in 16 patients with no residual or recurrent tumor. Two patients had residual tumors: the recurrence in the lateral wall of the sphenoid sinus in the first patient and in  the pterygopalatine fossa in the other patient. Follow-up ranged from 14 to 72 months with a mean of 37.4 months. The mean of intraoperative blood loss was 342.3 +/- 92.7 ml. The endonasal endoscopic approach is a safe and effective technique for small- and intermediate-sized JNAs (stage IA&B and IIA) without preoperative angiographic embolization. Hypotensive anesthesia, meticulous dissection as well as diathermy of the sphenopalatine artery greatly decrease the blood loss.

 

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[294]

TÍTULO / TITLE:  - Quantitative dynamic (18)FDG-PET and tracer kinetic analysis of soft tissue sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Oncol. 2012 Dec 3.

            ●● Enlace al texto completo (gratuito o de pago) 3109/0284186X.2012.728713

AUTORES / AUTHORS:  - Rusten E; Rodal J; Revheim ME; Skretting A; Bruland OS; Malinen E

INSTITUCIÓN / INSTITUTION:  - Department of Medical Physics, The Norwegian Radium Hospital, Oslo University Hospital , Oslo , Norway.

RESUMEN / SUMMARY:  - Purpose. To study soft tissue sarcomas using dynamic positron emission tomography (PET) with the glucose analog tracer [(18)F]fluoro-2-deoxy-D-glucose ((18)FDG), to investigate correlations between derived PET image parameters and clinical characteristics, and to discuss implications of dynamic PET acquisition (D-PET).  Material and methods. D-PET images of 11 patients with soft tissue sarcomas were  analyzed voxel-by-voxel using a compartment tracer kinetic model providing estimates of transfer rates between the vascular, non-metabolized, and metabolized compartments. Furthermore, standard uptake values (SUVs) in the early (2 min p.i.; SUV(E)) and late (45 min p.i.; SUV(L)) phases of the PET acquisition were obtained. The derived transfer rates K(1), k(2) and k(3), along with the metabolic rate of (18)FDG (MR(FDG)) and the vascular fraction nu(p), was fused with the computed tomography (CT) images for visual interpretation. Correlations  between D-PET imaging parameters and clinical parameters, i.e. tumor size, grade  and clinical status, were calculated with a significance level of 0.05. Results.  The temporal uptake pattern of (18)FDG in the tumor varied considerably from patient to patient. SUV(E) peak was higher than SUV(L) peak for four patients. The images of the rate constants showed a systematic pattern, often with elevated intensity in the tumors compared to surrounding tissue. Significant correlations  were found between SUV(E/L) and some of the rate parameters. Conclusions. Dynamic (18)FDG-PET may provide additional valuable information on soft tissue sarcomas not obtainable from conventional (18)FDG-PET. The prognostic role of dynamic imaging should be investigated.

 

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[295]

TÍTULO / TITLE:  - A 75-year-old woman with thoracic spinal cord compression and chloroma (granulocytic sarcoma).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Semin Oncol. 2012 Dec;39(6):e37-46. doi: 10.1053/j.seminoncol.2012.10.002.

            ●● Enlace al texto completo (gratuito o de pago) 1053/j.seminoncol.2012.10.002

AUTORES / AUTHORS:  - Baikaidi M; Chung SS; Tallman MS; Damon LE; Walker AR; Marcucci G; Sholi AM; Morris GJ

INSTITUCIÓN / INSTITUTION:  - Northeastern Radiation Oncology Center Scranton, PA, USA.

 

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[296]

TÍTULO / TITLE:  - Extraskeletal myxoid chondrosarcoma of the neck.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dentomaxillofac Radiol. 2013 Jan;42(1):20100355. doi: 10.1259/dmfr.20100355.

            ●● Enlace al texto completo (gratuito o de pago) 1259/dmfr.20100355

AUTORES / AUTHORS:  - Oh YJ; Yang I; Yoon DY; Cho SJ; Lee Y; Woo JY; Jung AY; Hong HS; Jeh SK

INSTITUCIÓN / INSTITUTION:  - Dr Ik Yang, Department of Radiology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, 948-1, Daerim 1-Dong, Yungdungpo-Gu, Seoul, Republic of Korea, 150-950. E-mail: ikyang@hallym.or.kr.

RESUMEN / SUMMARY:  - Extraskeletal myxoid chondrosarcoma is a rare malignant soft-tissue tumour that is typically in the deep soft tissues of the lower extremity. The tumour is usually a well-defined, multinodular soft-tissue mass without calcifications. A 62-year-old woman with a history of nasopharyngeal cancer presented with a palpable mass in the anterior neck. Radiologically, the lesion was a well-defined soft-tissue mass with the extensive calcifications on various imaging examinations. Although this lesion was histopathologically diagnosed as extraskeletal myxoid chondrosarcoma, the unusual imaging findings were challenging and very intriguing.

 

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[297]

TÍTULO / TITLE:  - Comparison between air and carbon dioxide insufflation in the endoscopic submucosal excavation of gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastroenterol. 2012 Dec 28;18(48):7296-301. doi: 10.3748/wjg.v18.i48.7296.

            ●● Enlace al texto completo (gratuito o de pago) 3748/wjg.v18.i48.7296

AUTORES / AUTHORS:  - Shi WB; Wang ZH; Qu CY; Zhang Y; Jiang H; Zhou M; Chen Y; Xu LM

INSTITUCIÓN / INSTITUTION:  - Wei-Bin Shi, Zi-Hao Wang, Han Jiang, Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China.

RESUMEN / SUMMARY:  - AIM: To evaluate the safety and efficacy of CO(2) insufflation compared with air  insufflation in the endoscopic submucosal excavation (ESE) of gastrointestinal stromal tumors. METHODS: Sixty patients were randomized to undergo endoscopic submucosal excavation, with the CO(2) group (n = 30) and the air group (n = 30) undergoing CO(2) insufflation and air insufflation in the ESE, respectively. The  end-tidal CO(2) level (pETCO(2)) was observed at 4 time points: at the beginning  of ESE, at total removal of the tumors, at completed wound management, and 10 min after ESE. Additionally, the patients’ experience of pain at 1, 3, 6 and 24 h after the examination was registered using a visual analog scale (VAS). RESULTS:  Both the CO(2) group and air group were similar in mean age, sex, body mass index (all P > 0.05). There were no significant differences in PetCO(2) values before and after the procedure (P > 0.05). However, the pain scores after the ESE at different time points in the CO(2) group decreased significantly compared with the air group (1 h: 21.2 +/- 3.4 vs 61.5 +/- 1.7; 3 h: 8.5 +/- 0.7 vs 42.9 +/- 1.3; 6 h: 4.4 +/- 1.6 vs 27.6 +/- 1.2; 24 h: 2.3 +/- 0.4 vs 21.4 +/- 0.7, P < 0.05). Meanwhile, the percentage of VAS scores of 0 in the CO(2) group after 1, 3, 6 and 24 h was significantly higher than that in the air group (60.7 +/- 1.4 vs 18.9 +/- 1.5, 81.5 +/- 2.3 vs 20.6 +/- 1.2, 89.2 +/- 0.7 vs 36.8 +/- 0.9, 91.3 +/- 0.8 vs 63.8 +/- 1.3, respectively, P < 0.05). Moreover, the condition of the  CO(2) group was better than that of the air group with respect to anal exsufflation. CONCLUSION: Insufflation of CO(2) in the ESE of gastrointestinal stromal tumors will not cause CO(2) retention and it may significantly reduce the level of pain, thus it is safe and effective.

 

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[298]

TÍTULO / TITLE:  - Spontaneous ICA rupture: A severe late complication after giant nasopharyngeal angiofibroma resection.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Pediatr Otorhinolaryngol. 2013 Jan 8. pii: S0165-5876(12)00724-0. doi: 10.1016/j.ijporl.2012.12.022.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijporl.2012.12.022

AUTORES / AUTHORS:  - Succo G; Gisolo M; Crosetti E; Bergui M; Danesi G

INSTITUCIÓN / INSTITUTION:  - ENT Department, S. Luigi Gonzaga Hospital, University of Turin, Turin, Italy.

RESUMEN / SUMMARY:  - Juvenile nasopharyngeal angiofibroma (JNA) is a benign vascular tumor occurring in young males. Surgery for giant JNA is a complex procedure, with a high risk of major complications. We report a rare case of massive epistaxis in a 15-year-old  boy resulting from spontaneous rupture of the intracavernous tract of the internal carotid artery 20 days after resection of a giant JNA by midface degloving. The event was managed by an emergency arteriography with coils selectively deployed to occlude the vessel and to stop hemorrhage. This treatment has been shown to be effective in producing immediate hemostasis and stable long-term occlusion.

 

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[299]

TÍTULO / TITLE:  - Primary malignant sarcomatoid mesothelioma in the pericardium.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Intern Med. 2013;52(2):249-53. Epub 2013 Jan 15.

AUTORES / AUTHORS:  - Tateishi K; Ikeda M; Yokoyama T; Urushihata K; Yamamoto H; Hanaoka M; Kubo K; Sakai Y; Nakayama J; Koizumi T

INSTITUCIÓN / INSTITUTION:  - The First Department of Internal Medicine, Shinshu University School of Medicine, Japan.

RESUMEN / SUMMARY:  - Primary malignant pericardial mesothelioma is an exceptionally rare tumor, and making an antemortem diagnosis of this disease is notoriously difficult. We herein report the case of a 61-year-old woman with pericardial mesothelioma who presented with shortness of breath and peripheral edema of the lower limbs. Chest computed tomography (CT) showed an anterior mass and thickened pericardium with multiple pericardial nodules. A biopsy of the mediastinal mass was performed using right thoracotomy, and the histological findings indicated a sarcomatoid tumor. The patient was treated with chemotherapy; however, she but died three months after diagnosis. An autopsy confirmed a final diagnosis of sarcomatoid type primary malignant pericardial mesothelioma following extensive immunohistopathological examinations.

 

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[300]

TÍTULO / TITLE:  - A three-plasma miRNA signature serves as novel biomarkers for osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oncol. 2013 Mar;30(1):340. doi: 10.1007/s12032-012-0340-7. Epub 2012 Dec 27.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12032-012-0340-7

AUTORES / AUTHORS:  - Ouyang L; Liu P; Yang S; Ye S; Xu W; Liu X

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, 430030, Hubei, China.

RESUMEN / SUMMARY:  - Osteosarcoma is the most common human primary malignant bone tumor in children and young adults. Sensitive and non-invasive biomarkers that can facilitate disease detection at early stage are highly desirable to improve survival rate and help to determine optimized treatment for osteosarcoma. The small non-coding  RNAs, microRNAs (miRNAs), have recently been identified as critical regulators for various diseases including cancer and may represent a novel class of cancer biomarkers. In this study, we aimed to detect the potential of circulating miRNAs as biomarkers for osteosarcoma. Levels of six candidate miRNAs (miR-21, miR-199a-3p, miR-143, miR-34, miR-140, and miR-132) that were previously demonstrated to be regulated in osteosarcoma were examined in plasma of 40 osteosarcoma patients and 40 matched healthy controls by quantitative reverse-transcription polymerase chain reaction assays. The results showed that circulating levels of miR-21 were significantly higher in osteosarcoma patients than controls, while miR-199a-3p and miR-143 were decreased in osteosarcoma patients. We replicated the findings in an independent study of 40 osteosarcoma patients and 40 matched controls and confirmed the results. Receiver operating characteristics curve analysis of the combined populations demonstrated that the  three-miRNA signature could discriminate cases from controls with an area under the curve of 0.953 (95 % CI 0.924-0.984). In addition, circulating miR-21 and miR-143 were correlated with both metastasis status and histological subtype of the patients, while miR-199a-3p only correlated with histological subtype. Our data suggest that altered levels of circulating miRNAs might have great potential to serve as novel, non-invasive biomarkers for osteosarcoma.

 

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[301]

TÍTULO / TITLE:  - Primary sarcomatoid malignant pericardial mesothelioma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Intern Med. 2013;52(1):157-8. Epub 2013 Jan 1.

AUTORES / AUTHORS:  - Jiang D; Kong M; Li J; Qian J

INSTITUCIÓN / INSTITUTION:  - Department of Heart Center, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China.

 

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[302]

TÍTULO / TITLE:  - Recurrent solitary fibrous tumor of the pleura with malignant transformation and  non-islet cell tumor-induced hypoglycemia due to paraneoplastic overexpression and secretion of high-molecular-weight insulin-like growth Factor II.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Intern Med. 2012;51(23):3267-72. Epub 2012 Dec 1.

AUTORES / AUTHORS:  - Tominaga N; Kawarasaki C; Kanemoto K; Yokochi A; Sugino K; Hatanaka K; Uekusa T; Fukuda I; Aiba M; Hizuka N; Uda S

INSTITUCIÓN / INSTITUTION:  - Division of Nephrology and Metabolism, Kanto Rosai Hospital, Japan.

RESUMEN / SUMMARY:  - A 41-year-old man was diagnosed with a solitary fibrous tumor (SFT) of the pleura in the posterior mediastinum. Despite two surgeries for excision, the SFT recurred and progressed with direct invasion of the chest wall and bone metastases. He was hospitalized because of cerebral infarction and presented with recurrent severe hypoglycemia fourteen years later. High-molecular-weight (HMW) insulin-like growth factor II (IGF-II) was identified in the serum and tumor using Western blotting and immunohistochemistry. These findings suggested that the cause of the recurrent severe hypoglycemia was SFT production of HMW IGF-II,  a mediator of non-islet cell tumor-induced hypoglycemia (NICTH).

 

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[303]

TÍTULO / TITLE:  - Rare pediatric presentation of aneurysmal bone cyst with trabecular juvenile ossifying fibroma and ossifying fibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Pediatr Otorhinolaryngol. 2013 Jan 7. pii: S0165-5876(12)00723-9. doi: 10.1016/j.ijporl.2012.12.021.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijporl.2012.12.021

AUTORES / AUTHORS:  - Urs AB; Augustine J; Arora S; Kumar P

INSTITUCIÓN / INSTITUTION:  - Department of Oral & Maxillofacial Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, India.

RESUMEN / SUMMARY:  - Aneurysmal bone cyst (ABC) is a benign intraosseous lesion characterized by blood filled spaces of varying sizes associated with a fibroblastic stroma containing multinucleated giant cells, osteoid and woven bone. ABC can present either singly or in association with osseous neoplasms such as ossifying fibroma (OF), giant cell granuloma etc. Juvenile ossifying fibroma has two variants: psammomatoid JOF (PJOF) and trabecular JOF (TJOF). ABC formation in TJOF is very rare in pediatric patients with only three cases reported in literature till date to the best of our knowledge. We hereby report three pediatric cases of ABC, two of which were associated with TJOF and one associated with OF.

 

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[304]

TÍTULO / TITLE:  - Giant solitary fibrous tumor arising from greater omentum.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastroenterol. 2012 Nov 28;18(44):6515-20. doi: 10.3748/wjg.v18.i44.6515.

            ●● Enlace al texto completo (gratuito o de pago) 3748/wjg.v18.i44.6515

AUTORES / AUTHORS:  - Zong L; Chen P; Wang GY; Zhu QS

INSTITUCIÓN / INSTITUTION:  - Liang Zong, Ping Chen, Guang-Yao Wang, Qun-Shan Zhu, Department of Gastrointestinal Surgery, Subei People’s Hospital, Yangzhou University, Yangzhou  225001, Jiangsu Province, China.

RESUMEN / SUMMARY:  - Extrathoracic solitary fibrous tumors (SFTs) have been described at almost every  anatomic location of human body, but reports of SFT in the abdominal cavity are rare. We herein present a rare case of SFT originating from greater omentum. Computed tomography revealed a 15.8 cm x 21.0 cm solid mass located at superior aspect of stomach. Open laparotomy confirmed its mesenchymal origin. Microscopically, its tissue was composed of non-organized and spindle-shaped cells exhibiting atypical nuclei, which were divided up by branching vessel and collagen bundles. Immunohistochemical staining showed that this tumor was negative for CD117, CD99, CD68, cytokeratin, calretinin, desmin, epithelial membrane antigen, F8 and S-100, but positive for CD34, bcl-2, alpha-smooth muscle actin and vimentin. The patient presented no evidence of recurrence during follow-up. SFT arising from abdominal cavity can be diagnosed by histological findings and immunohistochemical markers, especially for CD34 and bcl-2 positive  cases.

 

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[305]

TÍTULO / TITLE:  - Small intestine bleeding due to multifocal angiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastroenterol. 2012 Nov 28;18(44):6494-500. doi: 10.3748/wjg.v18.i44.6494.

            ●● Enlace al texto completo (gratuito o de pago) 3748/wjg.v18.i44.6494

AUTORES / AUTHORS:  - Zacarias Fohrding L; Macher A; Braunstein S; Knoefel WT; Topp SA

INSTITUCIÓN / INSTITUTION:  - Department of General, Visceral and Pediatric Surgery, Heinrich-Heine-University, Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.

RESUMEN / SUMMARY:  - We report a case of an 84-year-old male patient with primary small intestinal angiosarcoma. The patient initially presented with anemia and melena. Consecutive endoscopy revealed no signs of upper or lower active gastrointestinal bleeding. The patient had been diagnosed 3 years previously with an aortic dilation, which  was treated with a stent. Computed tomography suggested an aorto-intestinal fistula as the cause of the intestinal bleeding, leading to operative stent explantation and aortic replacement. However, an aorto-intestinal fistula was not found, and the intestinal bleeding did not arrest postoperatively. The constant need for blood transfusions made an exploratory laparotomy imperative, which showed multiple bleeding sites, predominately in the jejunal wall. A distal loop  jejunostomy was conducted to contain the small intestinal bleeding and a segmental resection for histological evaluation was performed. The histological analysis revealed a less-differentiated tumor with characteristic CD31, cytokeratin, and vimentin expression, which led to the diagnosis of small intestinal angiosarcoma. Consequently, the infiltrated part of the jejunum was successfully resected in a subsequent operation, and adjuvant chemotherapy with paclitaxel was planned. Angiosarcoma of the small intestine is an extremely rare  malignant neoplasm that presents with bleeding and high mortality. Early diagnosis and treatment are essential to improve outcome. A small intestinal angiosarcoma is a challenging diagnosis to make because of its rarity, nonspecific symptoms of altered intestinal function, nonspecific abdominal pain,  severe melena, and acute abdominal signs. Therefore, a quick clinical and histological diagnosis and decisive measures including surgery and adjuvant chemotherapy should be the aim.

 

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[306]

TÍTULO / TITLE:  - Presentation of Intramuscular Myxoma as an Unusual Neck Lump.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Maxillofac Surg. 2013 Jan 23. pii: S0278-2391(12)01626-6. doi: 10.1016/j.joms.2012.10.032.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.joms.2012.10.032

AUTORES / AUTHORS:  - Kalsi JS; Pring M; Hughes C; Fasanmade A

INSTITUCIÓN / INSTITUTION:  - Specialty Registrar, Department of Restorative Dentistry, Eastman Dental Hospital, London, UK. Electronic address: Jagdip82@hotmail.com.

RESUMEN / SUMMARY:  - Intramuscular myxoma (IM) has a distinct diagnostic identity among soft tissue myxomas. IMs have an approximate incidence of 1 per million of the population per year, with a female-to-male ratio of 14:3. The age range for presentation is 40 to 70 years, and the thigh is affected most frequently. IMs most commonly affect  larger muscle groups, making the head and neck a rare site. To the authors’ knowledge, there is 1 previous report of an IM presenting in the sternocleidomastoid muscle. In addition, IMs usually present as slow-growing asymptomatic swellings. Although abnormal gag reflexes have been reported in cases of glossopharyngeal schwannoma and neurofibroma in patients with neurofibromatosis-1, a gag reflex has not been reported previously as a complication of IM in the head and neck. A case of IM in the left sternocleidomastoid muscle, presenting with an intense gag reflex on palpation, in a 70-year-old woman is presented.

 

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[307]

TÍTULO / TITLE:  - Peri-operative morbidity associated with abdominal myomectomy for very large fibroid uteri.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Obstet Gynecol Reprod Biol. 2013 Jan 2. pii: S0301-2115(12)00558-1. doi: 10.1016/j.ejogrb.2012.12.010.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ejogrb.2012.12.010

AUTORES / AUTHORS:  - Pundir J; Krishnan N; Siozos A; Uwins C; Kopeika J; Khalaf Y; El-Toukhy T

INSTITUCIÓN / INSTITUTION:  - Assisted Conception Unit, Guy’s and St. Thomas’ NHS Trust, London, UK. Electronic address: jyotsnapundir@yahoo.com.

RESUMEN / SUMMARY:  - OBJECTIVE: To evaluate the safety of abdominal myomectomy for very large fibroid  uteri, and to assess the effect of relevant confounding variables on the occurrence of major peri-operative complications. STUDY DESIGN: A cohort study of 200 abdominal myomectomies for fibroid uteri of 16 gestational weeks or greater.  Logistic regression analysis was used to examine the influence of important clinical variables on the risk of complications. A systematic literature search was conducted for evidence related to peri-operative morbidity associated with abdominal myomectomy for very large fibroid uteri. RESULTS: The mean (+/-standard deviation) uterine size was 21+/-5 weeks. The overall rate of major complications was 30%. Peri-operative bleeding necessitating blood transfusion occurred in 49 (24.5%) cases. During surgery, two patients had bowel injury, two had bladder injury, seven women returned to theatre and two (1%) had hysterectomy. Four patients were re-admitted within 14 days of surgery. Multivariable logistic regression analysis showed that the risk of major complications was significantly higher in cases with a uterine size of 20 gestational weeks or more [odds ratio (OR) 3.4, 95% confidence interval (CI) 1.1-10.2; p=0.03], where 10 or more fibroids were removed (OR 3.5, 95% CI 1.1-10.8; p=0.05) and where midline skin incision was required (OR 6.1, 95% CI 1.7-22.3; p=0.006). On comparison of primary vs repeat abdominal myomectomy, there was significantly higher blood loss (mean 1023+/-1112ml vs 579+/-787ml; p=0.02) and risk of major complications in the repeat myomectomy group (40% vs 5%; p<0.001). The systematic review identified only one study that reported a comparable risk of major complications  related to abdominal myomectomy for very large fibroid uteri. CONCLUSION: The risk of organ injury, hysterectomy, re-operation or hospital re-admission after abdominal myomectomy for very large fibroid uteri is low, but the procedure is associated with a significant risk of bleeding necessitating blood transfusion. This risk is increased after repeat myomectomy, and in patients with a uterine size of 20 gestational weeks or larger, requiring removal of 10 or more fibroids, and requiring a midline skin incision.

 

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[308]

TÍTULO / TITLE:  - Diplopia From Pleomorphic Lipoma of the Orbit With Lateral Rectus Muscle Involvement.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ophthal Plast Reconstr Surg. 2013 Jan 16.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IOP.0b013e31826a5112

AUTORES / AUTHORS:  - Fernandez NT; Stoica BT; Saavedra IG; Saenz SG; San Juan AV; Goriba AN; Conde E

INSTITUCIÓN / INSTITUTION:  - *Hospital Universitario de Fuenlabrada; daggerHospital Universitario de Mostoles; double daggerHospital Madrid Norte Sanchinarro; and section signLaboratorio de Dianas Terapeuticas, Centro Oncologico Integral Clara Campal, Hospital Madrid Norte Sanchinarro, Madrid, España.

RESUMEN / SUMMARY:  - A-55-year-old man with a 2-year history of left proptosis with painless swelling  of the upper and lateral bulbar conjunctiva was referred. He had developed diplopia in left gaze. Orbital CT showed left proptosis with a mass measuring 2 x 1 cm in the superolateral and lateral left orbit, with lateral rectus muscle infiltration. The lesion was excised and was found to be diffuse, and an infiltrative mass affecting the anterior portion of the lateral rectus muscle was also removed. The histopathologic diagnosis was pleomorphic lipoma. Only 7 cases  of pleomorphic lipomas occurring in ocular adnexal tissues or in the orbit have been previously reported, but in none of the cases had an infiltration of the lateral rectus muscle or diplopia been described before. The histopathologic features and differential diagnosis of this type of soft tissue tumor are also described.

 

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[309]

TÍTULO / TITLE:  - Intraorbital Metastasis From Solitary Fibrous Tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ophthal Plast Reconstr Surg. 2013 Jan 16.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IOP.0b013e318272f311

AUTORES / AUTHORS:  - Patel MM; Jakobiec FA; Zakka FR; Du R; Annino DJ; Borboli-Gerogiannis S; Daniels AB

INSTITUCIÓN / INSTITUTION:  - * Department of Ophthalmology, Massachusetts Eye and Ear Infirmary,daggerDepartment of Neurosurgery, Brigham and Women’s Hospital, and double daggerDepartment of Otorhinolaryngology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.

RESUMEN / SUMMARY:  - Solitary fibrous tumor (SFT) is a rare spindle cell tumor of mesenchymal origin that usually arises from pleura or pericardium but can also arise from many extraserosal sites. Although more than 50 cases of primary SFT of the orbit have  been reported, there are no reports to date of a malignant nonophthalmic SFT metastasizing in the orbital soft tissues (although sphenoid wing bony involvement has been reported). The authors report here the first case of a patient with intraorbital metastasis of a CD34-positive malignant SFT. The patient was a 57-year-old man with a history of malignant pleural SFT and a prior kidney metastasis. He presented with the rapid appearance of proptosis and massive conjunctival chemosis preventing eyelid closure, and he was found to have a well-circumscribed metastasis to his lateral rectus muscle. Surgical excision cured his ocular symptoms, although he died 3 months later from brain and widespread metastases.

 

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[310]

TÍTULO / TITLE:  - Primary Extraosseous Ewing Sarcoma of the Orbit.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ophthal Plast Reconstr Surg. 2012 Dec 14.

            ●● Enlace al texto completo (gratuito o de pago) 1097/IOP.0b013e3182771549

AUTORES / AUTHORS:  - Alio JL 2nd; Sales-Sanz M; Vaz MA; Barrancos C; Reguero ME; Diamantopoulus J; Poveda P

INSTITUCIÓN / INSTITUTION:  - *Oculoplastic and Orbital Surgery Unit, Ophthalmology Department, and Departments of daggerOncology and double daggerPathology, Ramon y Cajal University Hospital,  Madrid, España; section signNeurosurgery Department, Hospitales de Madrid, Madrid, España; and ||Neurosurgery Department, Hospital Universitario de Getafe, Madrid, España.

RESUMEN / SUMMARY:  - A 40-year-old man presented with painless, progressive vision loss and mild proptosis of the OD. CT revealed a right intraconal mass with slight penetration  of the optic canal not contiguous with any bony structure. Incisional biopsy through a transfrontal orbitotomy revealed a diffuse growth of homogeneous, small, round cells. Immunohistochemical stains were positive for vimentin and MIC2 (CD99), and the translocation at EWS gene (22q12) was detected. Metastatic workup and a full-body bone scan were negative, confirming primary orbital extraosseous Ewing sarcoma. The patient received neoadjuvant chemotherapy and an  orbital exenteration with preservation of eyelids and conjunctiva. He also received adjuvant chemotherapy and local radiotherapy, and he has remained disease-free for almost 3 years.

 

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[311]

TÍTULO / TITLE:  - Cytogenetic analysis of a low-grade secondary peripheral chondrosarcoma arising in synovial chondromatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - In Vivo. 2013 Jan-Feb;27(1):57-60.

AUTORES / AUTHORS:  - Kyriazoglou AI; Rizou H; Dimitriadis E; Arnogiannaki N; Agnantis N; Pandis N

INSTITUCIÓN / INSTITUTION:  - Department of Genetics, Saint Savvas Hospital, 171 Alexandras Avenue, 11522 Athens, Greece. tassoskyr@gmail.com

RESUMEN / SUMMARY:  - Secondary chondrosarcoma is a malignant chondroid tumor arising in a benign precursor. Synovial chondromatosis is a benign chondroid lesion that rarely transforms to chondrosarcoma. We present the case of a 54-year-old male with the  diagnosis of low-grade secondary peripheral chondrosarcoma developed in the context of synovial chondromatosis. Cytogenetics revealed a novel aberration t(1;14)(q23.1~24;q24.1~3). Multicolor banding (mBAND) analysis described the chromosomal regions involved in this translocation with a higher detail. Diagnosis of such borderline lesions is very difficult and cytogenetics is helpful in characterizing these tumors.

 

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[312]

TÍTULO / TITLE:  - Thymolipoma With Sebaceous Differentiation: A Hitherto Unreported Variant of Thymolipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Pathol. 2013 Jan 27.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1066896912473357

AUTORES / AUTHORS:  - Ajaz B; Tran TA; Truong T; Manoucheri M

RESUMEN / SUMMARY:  - Thymolipoma is a very rare anterior mediastinal mass of thymic origin, accounting for only 2% to 10% of all thymic neoplasm. Histologically, the tumor is usually composed of adipose tissue interspersed with thymic tissues. We report a case of  a 58-year-old man who presented with a few weeks history of shortness of breath,  cough, and chest pain, found to have a retrocardiac infiltrate on chest X-ray. Computed tomography scan of the chest showed a large anterior mediastinal mass. Surgical excision revealed an ovoid fatty mass, which on histological examination displayed thymic tissue intermixed with lipomatous tissue consistent with a thymolipoma. Of note was the presence of a microscopic nodule of thymic epithelial proliferation with sebaceous differentiation and focal cylindroma-like architecture. Although sebaceous tissue has been rarely reported in thymic tissue, to the best of our knowledge, this is the first case report of sebaceous  differentiation in a thymolipoma.

 

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[313]

TÍTULO / TITLE:  - Dermatofibroma located on the tarsal plate after upper blepharoplasty?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniofac Surg. 2013 Jan;24(1):e26-8. doi: 10.1097/SCS.0b013e31827a0093.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SCS.0b013e31827a0093

AUTORES / AUTHORS:  - Kang HG; Jang YJ; Park MC; Shin SJ

INSTITUCIÓN / INSTITUTION:  - From the Department of Plastic and Reconstructive Surgery, Ajou University Hospital, Suwon, Korea.

RESUMEN / SUMMARY:  - ABSTRACT: Dermatofibroma is a firm, skin-colored or reddish-brown sessile papule  or nodule. It arises spontaneously without a known cause or after a minor trauma, such as an insect bite. A 39-year-old Asian woman complained of a palpable mass and tenderness in the right upper eyelid. On physical examination, a firm palpable subcutaneous mass was detected in the upper eyelid. Surgical exploration under local anesthesia showed a fibrotic and firmly attached mass to the tarsal plate. In histopathologic examination, the mass was characterized by a fibroblast proliferation in the dermis with an overlying hyperplastic epidermis with frequent basal hyperpigmentation. As far as we know, there have been no previous  reports of dermatofibroma located on the tarsal plate. This article is a good example for intratarsal location of dermatofibroma.

 

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[314]

TÍTULO / TITLE:  - Spontaneous malignant transformation in craniomaxillofacial fibrous dysplasia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Craniofac Surg. 2013 Jan;24(1):141-5. doi: 10.1097/SCS.0b013e3182646126.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SCS.0b013e3182646126

AUTORES / AUTHORS:  - Cheng J; Yu H; Wang D; Ye J; Jiang H; Wu Y; Shen G

INSTITUCIÓN / INSTITUTION:  - From the *Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu; and daggerDepartment of Oral and Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

RESUMEN / SUMMARY:  - ABSTRACT: Spontaneous malignant transformation in craniomaxillofacial fibrous dysplasia (FD) is extremely rare and its clinicopathological characteristics remain largely unknown. Here, we aimed to characterize the epidemiology and clinicopathological features of malignancies arising from preexisting FD by presenting data from a Chinese tertiary referral hospital and review of English and Chinese literatures. The craniomaxillofacial disease registry of Shanghai Ninth People’s Hospital was searched and reviewed to collect relevant information for patients diagnosed as malignant transformation in craniomaxillofacial FD between January 1993 and December 2010. An English and Chinese literature review  was conducted to retrieve pertinent cases published in the past 2 decades with preset inclusion criteria. All included cases were further analyzed with regard to associated clinical and pathological variables. Three cases with osteosarcoma  arising from previous craniomaxillofacial FD were found at our institution and 35 other cases were identified by literature review. These uncommon entities usually occurred in adults with a mean age of 39.8 years and equal gender preponderance.  Maxilla remained the most common sites for malignancies followed by mandible and  zygoma. Most malignancies were diagnosed as osteosarcoma followed by fibrosarcoma, chondrosarcoma, and malignant fibrous histiocytoma. Radical resection alone or with postoperative radiotherapy/chemotherapy remains the main  treatment strategy with unfavorable prognosis due to local recurrence and distant metastasis. Taken together, our findings might for the first time provide the comprehensive information regarding the epidemiology, clinicopathological features, treatment, and prognosis of malignancies in craniomaxillofacial FD. Further investigations are warranted to improve early diagnosis and proper treatment for these uncommon entities.

 

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[315]

TÍTULO / TITLE:  - True carcinosarcoma of the larynx.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Laryngol Otol. 2013 Jan;127(1):100-3. doi: 10.1017/S002221511200285X. Epub 2012 Dec 7.

            ●● Enlace al texto completo (gratuito o de pago) 1017/S002221511200285X

AUTORES / AUTHORS:  - Zhang M; Zhao LM; Li XM; Zhou L; Lin L; Wang SY

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China.

RESUMEN / SUMMARY:  - Objective: To explore the diagnosis and treatment of carcinosarcoma of the larynx. Methods: Clinical information, including presentation, pathology, treatment and outcome, was obtained from a review of patient charts. Results: Seven male patients were confirmed pathologically to have had carcinosarcoma between 2003 and 2009 in our hospital. All patients underwent surgery: four total laryngectomies, two vertical partial laryngectomies, and one supracricoid partial laryngectomy-cricohyoidopexy. The mean follow up was 40.6 months. At the time of  writing, six patients were alive and being followed; two of these suffered regional metastasis to the cervical lymphatic nodes and underwent radical neck dissection. One patient died of multiple distant metastases 60 months post-operatively. Conclusion: Carcinosarcoma of the larynx describes a biphasic tumour showing both carcinomatous and sarcomatous differentiation. It is extraordinarily rare and prone to metastasise to the cervical lymph nodes. Complete surgical resection of laryngeal primary lesions with wide margins and suitable neck dissection of cervical nodes is reasonable therapy.

 

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[316]

TÍTULO / TITLE:  - Recurrent skeletal muscle and abdominopelvic low-grade leiomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Gynaecol Obstet. 2012 Dec 7. pii: S0020-7292(12)00574-7. doi: 10.1016/j.ijgo.2012.09.014.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijgo.2012.09.014

AUTORES / AUTHORS:  - Gottfried-Blackmore A; Chan J; Caputo TA; Fahey TJ; Pasmantier MW; Gupta D; Frey MK

INSTITUCIÓN / INSTITUTION:  - Weill Cornell Medical College, New York, NY, USA.

 

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[317]

TÍTULO / TITLE:  - Small intestinal angiosarcoma masquerading as an appendiceal abscess.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann R Coll Surg Engl. 2013 Jan;95(1):22-4. doi: 10.1308/003588413X13511609955373.

            ●● Enlace al texto completo (gratuito o de pago) 1308/003588413X13511609955373

AUTORES / AUTHORS:  - Liu DSh; Smith H; Lee MM; Djeric M

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Level 8, Austin Hospital, 145 Studley Road, Heidelberg, Victoria 3084, Australia. dshliu@bigpond.com.

RESUMEN / SUMMARY:  - Angiosarcomas of the small intestine are rare and present non-specifically. They  usually manifest with abdominal discomfort, altered bowel habits, anaemia and gastrointestinal bleeding. Diagnosis is often challenging and occurs at an advanced tumour stage. We describe a case of a terminal ileum angiosarcoma masquerading as an appendiceal abscess, and discuss salient clinicopathological features in diagnosing and managing this disease.

 

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[318]

TÍTULO / TITLE:  - Ewing’s Sarcoma/Primitive Neuroectodermal Tumor of the Proximal Humeral Epiphysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orthopedics. 2013 Jan 1;36(1):e113-6. doi: 10.3928/01477447-20121217-29.

            ●● Enlace al texto completo (gratuito o de pago) 3928/01477447-20121217-29

AUTORES / AUTHORS:  - Morris P; Dickman PS; Seidel MJ

RESUMEN / SUMMARY:  - Ewing’s sarcoma/primitive neuroectodermal tumor (ES/PNET) of bone is a rare childhood tumor most commonly located in the metadiaphysis. In skeletally immature patients, lesions of the epiphysis are rarely malignant, with the most common diagnosis being chondroblastoma. This article presents a case of ES/PNET of the proximal humeral epiphysis in a 12-year-old boy. To the authors’ knowledge, this is the first reported case of epiphyseal ES/PNET confirmed with molecular testing. Radiographs of the patient’s painful shoulder showed a well-defined lytic lesion within the humeral epiphysis. Magnetic resonance imaging suggested a chondroid tumor with surrounding edema. Based on the imaging  characteristics, the patient’s age, and the lesion’s location, a preliminary diagnosis of chondroblastoma was made. A trochar biopsy of the lesion demonstrated a small, round, blue cell tumor on frozen section. Subsequently, immunohistochemical staining was uniformly positive in a membrane pattern for CD99, and molecular diagnostic testing demonstrated a EWSR1/FLI1 fusion transcript, confirming the pathologic diagnosis of ES/PNET. Although metadiaphyseal locations for ES/PNET are most common, this case adds to previously reported cases of epiphyseal ES/PNET, suggesting that the diagnosis be considered for pediatric epiphyseal tumors. This case also demonstrates why following rigorous oncologic treatment algorithms by obtaining a limited trochar  biopsy, even in the case of a confident radiographic diagnosis, is critically important; the biopsy results can lead to a major change in treatment and avoid contamination of a larger area of soft tissue and bone.

 

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[319]

TÍTULO / TITLE:  - Elevated 99mTc 3PRGD2 Activity in Benign Metastasizing Leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Nucl Med. 2013 Feb;38(2):117-9. doi: 10.1097/RLU.0b013e318279f14d.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RLU.0b013e318279f14d

AUTORES / AUTHORS:  - Jin X; Meng Y; Zhu Z; Jing H; Li F

INSTITUCIÓN / INSTITUTION:  - From the *Department of Nuclear Medicine and daggerPathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,1 Shuai Fu Yuan Hu Tong, Beijing, People’s Republic of China.

RESUMEN / SUMMARY:  - ABSTRACT: PET/CT scan was performed in a 43-year-old woman to evaluate pulmonary  nodules/masses. The images showed that there was only minimal FDG activity in the masses. However, these soft tissue masses in the lungs had significantly elevated Tc 3PRGD2 activity. Pathological examination demonstrated that this patient suffered benign metastasizing leiomyoma.

 

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[320]

TÍTULO / TITLE:  - Cardiac Lipoma at Unusual Location - Mimicking Atrial Myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Echocardiography. 2013 Jan 11. doi: 10.1111/echo.12093.

            ●● Enlace al texto completo (gratuito o de pago) 1111/echo.12093

AUTORES / AUTHORS:  - Singh B; Bhairappa S; Shankar SK; Prasad NM; Manjunath CN

INSTITUCIÓN / INSTITUTION:  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India.

RESUMEN / SUMMARY:  - Cardiac lipomas are one of the rare primary benign neoplasms composed of mature fat cells. The tumor originates mostly in the subendocardium and subepicardium but very rarely within the myocardium. Clinically, this tumor is asymptomatic and found incidentally in the vast majority of cases. We report a 26-year-old female  presenting with atypical chest pain. Transthoracic echocardiogram showed a mass in relation to interatrial septum suggestive of atrial myxoma, but was confirmed  to be cardiac lipoma on magnetic resonance imaging. Owing to the asymptomatic character and the benign nature of the tumor, a decision for conservative management was made.

 

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[321]

TÍTULO / TITLE:  - A Voluminous Right Atrial Myxoma Revealed by Right Side Heart Failure.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Echocardiography. 2012 Dec 10. doi: 10.1111/echo.12069.

            ●● Enlace al texto completo (gratuito o de pago) 1111/echo.12069

AUTORES / AUTHORS:  - Nazzi M; Belhachmi H; Badidi M; Zbir E; Mohty D

INSTITUCIÓN / INSTITUTION:  - Cardiology Department, My Ismail Military Hospital, Meknes, Morocco.

 

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[322]

TÍTULO / TITLE:  - Microinvasive Lobular Carcinoma Arising in a Fibroadenoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Pathol. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1066896912471854

AUTORES / AUTHORS:  - Hayes BD; Quinn CM

RESUMEN / SUMMARY:  - A 51-year-old woman had a 35 mm circumscribed calcified lesion identified on screening mammography, designated R4. Excision showed a fibroadenoma with multiple foci of lobular neoplasia (atypical lobular hyperplasia and classical lobular carcinoma in situ [LCIS]). A focus of microinvasive lobular carcinoma (MILC) was also present, confirmed on immunohistochemistry. The MILC cells were ER positive, Her-2-negative, and e-cadherin negative. Microinvasive carcinoma, defined as “invasive carcinoma with no focus measuring >1 mm” (TNM UICC 7th edition) is usually encountered in ductal carcinoma in situ but may occur with classical, florid, or pleomorphic LCIS. In one series MILC constituted 0.4% of all invasive lobular carcinomas and was present in 0.4% of all LCIS. MILC is a histologically subtle lesion, the identification of which lends further weight to the concept of lobular neoplasia as a precursor lesion. MILC has been observed in hamartoma but, to our knowledge, has not previously been reported in fibroadenoma.

 

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[323]

TÍTULO / TITLE:  - Salivary Gland Pleomorphic Adenoma With Giant Cell Tumor Component.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Pathol. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1066896912471853

AUTORES / AUTHORS:  - Handra-Luca A; Benzakin S

 

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[324]

TÍTULO / TITLE:  - Benign fibrous histiocytoma of the cheek.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Am J Otolaryngol. 2012 Dec 4. pii: S0196-0709(12)00214-1. doi: 10.1016/j.amjoto.2012.09.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.amjoto.2012.09.008

AUTORES / AUTHORS:  - Ding YF; Hao SP

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

RESUMEN / SUMMARY:  - Benign fibrous histiocytoma (FH) is a benign neoplasm of a mixture of fibroblastic and histiocytic cells. The tumor occurs most frequently on the skin  of the extremities but rarely in deep soft tissues of the head and neck. The diagnosis of benign FH may be clinically difficult, and is frequently confirmed after excision. The most important diagnostic distinction is the separation of this tumor from malignant FH. A 22-year-old male presented with a painless swelling mass on the left cheek. Detailed clinical and laboratory examinations were performed. The patient received angiography with embolization and underwent  an intraoral excision of the mass under general anesthesia with primary closure.  The histopathology revealed a benign FH. The complete image survey and appropriate treatment of benign FH of the cheek are emphasized.

 

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[325]

TÍTULO / TITLE:  - Low-grade fibromyxoid sarcoma: an unusual cardiac location.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cardiovasc Pathol. 2013 Jan 2. pii: S1054-8807(12)00150-0. doi: 10.1016/j.carpath.2012.11.004.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.carpath.2012.11.004

AUTORES / AUTHORS:  - Ferlosio A; Doldo E; Polisca P; Orlandi A

INSTITUCIÓN / INSTITUTION:  - Department of Biomedicine and Prevention, “Tor Vergata” University, Rome, Italy.

RESUMEN / SUMMARY:  - We report the unusual cardiac localization of a primary low-grade fibromyxoid sarcoma of the right ventricle in a 57-year-old woman. Histological examination revealed a prevalent myxoid appearance with whorling growth pattern of small or spindle cells with bland features alternating with rare more collagenous hypocellular areas with rare atypical cells. Genomic polymerase chain reaction of genomic DNA revealed the typical FUS/Creb3L2 fusion gene products typical of low-grade fibromyxoid sarcoma. The tumor was surgically removed and recurred after 7 years as high-grade pleomorphic sarcoma. The patient died 6 months after  the clinical manifestation of recurrence. Low-grade fibromyxoid sarcoma of soft tissues is a rare, distinctive variant of fibrosarcoma-typically arising in deep  soft tissue of lower extremities and trunk-that rarely metastasizes. Clinically,  low-grade fibromyxoid sarcoma is characterized by a longer survival rate compared to other sarcomas, suggesting its consideration in the differential diagnosis of  cardiac tumors with a myxoid appearance.

 

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[326]

TÍTULO / TITLE:  - Inhaled lipid cisplatin (ILC) in the treatment of patients with relapsed/progressive osteosarcoma metastatic to the lung.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2012 Dec 19. doi: 10.1002/pbc.24438.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24438

AUTORES / AUTHORS:  - Chou AJ; Gupta R; Bell MD; Riewe KO; Meyers PA; Gorlick R

INSTITUCIÓN / INSTITUTION:  - Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York. choua@mskcc.org.

RESUMEN / SUMMARY:  - BACKGROUND: Osteosarcoma treatment failure is most often from the inability to control metastatic disease in the lungs. Encapsulating cisplatin within lipid complexes and delivering the agent via inhalation targets lung metastases with minimal systemic exposure. An open-label, phase Ib/IIa study was performed to characterize the safety and efficacy of inhaled lipid cisplatin (ILC) in recurrent osteosarcoma patients who only had pulmonary metastases. PROCEDURE: ILC was administered via nebulizer every 2 weeks (=1 cycle). Response was evaluated radiographically every 2 cycles. Cisplatin levels were measured in patients. When possible, metastasectomy was undertaken in patients after 2 cycles. RESULTS: Nineteen patients were treated. No patients experienced hematologic toxicity, nephrotoxicity or ototoxicity. Nausea/vomiting (>/=grade 3) was attributed to study drug in one patient. Respiratory symptoms were observed in 13/19 patients with only one patient experiencing a >/=grade 3 respiratory symptom (not related  to study drug). Systemic cisplatin exposure was minimal. Eleven patients had bulky disease, and all progressed prior to cycle 7. Eight patients had all lesions </=2 cm. One patient had a sustained partial response. An additional two  patients had stable disease after 2 cycles, underwent metastasectomy, and remained free from pulmonary recurrence 1 year after initiation of therapy. CONCLUSIONS: ILC is well tolerated in heavily treated osteosarcoma patients and did not appear to have the typical toxicities associated with intravenous cisplatin. Three of eight patients with less bulky disease had sustained benefit. Further study of ILC is warranted. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc.

 

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[327]

TÍTULO / TITLE:  - Airway evaluation for magnetic resonance imaging sedation in pediatric patients with plexiform neurofibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Middle East J Anesthesiol. 2012 Feb;21(4):631-4.

AUTORES / AUTHORS:  - Abdallah C

INSTITUCIÓN / INSTITUTION:  - Division of Anesthesiology, The George Washington University Medical Center, 111  Michigan Avenue, N.W., Washington D.C. 20010-2970, USA. cabdalla@cnmc.org

 

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[328]

TÍTULO / TITLE:  - Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2012 Dec 19. doi: 10.1002/pbc.24412.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24412

AUTORES / AUTHORS:  - Rao-Bindal K; Rao CK; Yu L; Kleinerman ES

INSTITUCIÓN / INSTITUTION:  - Division of Pediatrics, The University of Texas, MD Anderson Cancer Center, Houston, Texas.

RESUMEN / SUMMARY:  - OBJECTIVE(S): We have previously shown that Fas expression inversely correlates with the metastatic potential of osteosarcoma (OS) to the lung. FasL is constitutively expressed in the lung microenvironment and eliminates Fas(+) OS cells leaving Fas(-) cells to form metastases. Absence of FasL in the lung epithelium or blocking the Fas-signaling pathway interfered with this clearance mechanism allowing Fas(+) cells to remain and form lung metastases. We also demonstrated that while the majority of patient OS lung metastases were Fas(-) ,  10-20% of the lesions contained Fas(+) cells, suggesting that these cells were not sensitive to FasL-induced apoptosis. The expression of c-FLIP, an inhibitor of the Fas pathway, has been associated with tumor development, progression, and  resistance to chemotherapy. We therefore evaluated the expression of c-FLIP in OS patient tumor specimens and human xenograft lung metastases. METHODS: OS patient  tissues, which included both primary and metastatic lesions, were evaluated for the expression of c-FLIP. In addition, tumors from human OS xenografts were examined for c-FLIP expression. RESULTS: c-FLIP expression was significantly higher in the lung metastases than in the primary tumors. CONCLUSION(S): c-FLIP may play an important role in the metastatic potential of OS to the lung. Inhibition of c-FLIP may be a future therapeutic target. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc.

 

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[329]

TÍTULO / TITLE:  - Chemotherapeutically Induced Cutaneous Tuberculosis after BCG Injection in a Patient with Pelvic Osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Surg Infect (Larchmt). 2012 Dec;13(6):406-8. doi: 10.1089/sur.2011.117. Epub 2012 Dec 16.

            ●● Enlace al texto completo (gratuito o de pago) 1089/sur.2011.117

AUTORES / AUTHORS:  - Zoccali G; Cota C; Marolda G; Ferraresi V; Giuliani M; Zoccali C

INSTITUCIÓN / INSTITUTION:  - 1 Plastic and Reconstructive Section, Department of Health Sciences, University of L’Aquila , L’Aquila, Italy .

RESUMEN / SUMMARY:  - Abstract Background: Tuberculosis (TB) is a serious infection afflicting a multitude of people worldwide. Recently, its prevalence has increased. The incidence of skin involvement generally is low. Bacillus Calmette-Guerin (BCG) is a live attenuated strain of Mycobacterium bovis that typically is administered as a vaccine to stimulate the immune system when treating some early neoplasms or to guard against tuberculosis. Methods: Case report and literature review. Case Report: The authors describe a young man with osteosarcoma of the left hemipelvis who received intradermal BCG injection for immune stimulation prior to surgery. In the course of neoadjuvant chemotherapy, he developed cutaneous tuberculosis. Conclusion: It is our opinion that BCG injection should be avoided in all patients requiring surgery, especially in oncologic patients, where the immunodeficiency brought on by chemotherapy predisposes to active opportunistic infection.

 

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[330]

TÍTULO / TITLE:  - Loss of connexin43 expression in Ewing’s sarcoma cells favors the development of  the primary tumor and the associated bone osteolysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochim Biophys Acta. 2013 Jan 9. pii: S0925-4439(13)00004-5. doi: 10.1016/j.bbadis.2013.01.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bbadis.2013.01.001

AUTORES / AUTHORS:  - Julie T; Regis B; Gaelle P; Jerome A; Julie C; Gwenola B; Verena S; Franck T; Dominique H; Francoise R; Franck V

INSTITUCIÓN / INSTITUTION:  - LUNAM Universite, France; INSERM, UMR 957, Nantes, France; Universite de Nantes,  Laboratoire de Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs  Osseuses Primitives, Nantes, France; CHU Hotel Dieu, Nantes, France; Equipe labellisee Ligue contre le Cancer 2012, Nantes, France.

RESUMEN / SUMMARY:  - Ewing’s sarcoma (ES) is a primary bone tumor characterized by a chromosomic translocation between the EWS gene and a member of the ETS gene family, mainly FLI1, which leads to an aberrant transcription factor EWS-FLI1 that promotes tumorigenicity. Gap junctions are intercellular channels composed of transmembrane proteins (connexin: Cx), that allow direct intercellular communication between adjacent cells. Numerous studies have shown that tumorigenesis may be associated with a loss of gap junctional intercellular communication (GJIC). Loss of Cx43 expression was observed at the protein and mRNA levels in ES cell lines compared to those measured in human mesenchymal stem cells. A673 ES cells stably transfected with an shRNA targeting EWS-FLI1 showed an increase in Cx43 expression (at the mRNA, protein and transcriptional levels)  and GJIC. In an osteolytic murine model of ES, the overexpression of Cx43 in ES cells dramatically reduced tumor growth, leading to a significant increase in animal survival. In vitro assays showed that Cx43 overexpression increases the p27 level with an associated marked decrease of Rb phosphorylation, consistent with the observed blockade of the cell cycle in G0/G1 phase. In addition, the bone microarchitectural parameters, assessed by micro-CT analysis, showed an increased bone volume when Cx43 expression was enhanced. Histological analysis demonstrated that the overexpression of Cx43 in ES tumor cells inhibits osteoclast activity and therefore bone resorption. Our study demonstrated that the loss of Cx43 expression in ES cells plays a crucial role in the development of the primary tumor and the associated bone osteolysis.

 

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[331]

TÍTULO / TITLE:  - Case Report: Osteoid Osteoma of the Acetabulum Treated With Arthroscopy-assisted  Radiofrequency Ablation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Orthop Relat Res. 2013 Jan 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11999-012-2772-y

AUTORES / AUTHORS:  - Ricci D; Grappiolo G; Franco M; Della Rocca F

INSTITUCIÓN / INSTITUTION:  - Division of Orthopedic Surgery, Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, Milan, Italy, damiano.ricci@humanitas.it.

RESUMEN / SUMMARY:  - BACKGROUND: Osteoid osteomas consist of a nidus surrounded by reactive sclerotic  bone. The diagnosis typically is based on imaging and clinical presentation involving nocturnal pain. Removal of the lesion is essential and currently is performed mainly with image-guided, minimally invasive techniques. We describe a  case involving an osteoid osteoma of the acetabular fossa, treated with arthroscopy-assisted radiofrequency ablation. CASE DESCRIPTION: A 47-year-old woman presented with a 9-month history of right groin pain and limited motion. The CT and MR images showed synovitis around the ligamentum teres and a nidus of  the acetabular fossa, surrounded by sclerotic bone and protruding from the inner  part of the lamina quadrilateral. Synovectomy and debridement of the ligamentum teres were performed, followed by radiofrequency ablation of the osteoid osteoma  under direct arthroscopic observation of the hip, avoiding resection of the normal bone around the nidus and preserving the integrity of the quadrilateral lamina and cartilage. The patient had complete pain relief the next day with minimal morbidity and rapid functional restoration. At the 22-month clinical followup, the patient was asymptomatic, and the CT and MR images obtained 1 year  after surgery showed no pathologic signs or synovitis. LITERATURE REVIEW: Our case was the fifth such case to be treated with hip arthroscopy and the first of  these to our knowledge to be treated with the arthroscopy-assisted radiofrequency ablation technique. PURPOSES AND CLINICAL RELEVANCE: Arthroscopy-assisted radiofrequency ablation is a combined treatment technique that may be used for intraarticular lesions of the hip that otherwise would require a difficult approach and jeopardize damage to cartilage and bone and also treat concomitant synovitis.

 

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[332]

TÍTULO / TITLE:  - Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Cancer Ther. 2013 Jan 11.

            ●● Enlace al texto completo (gratuito o de pago) 1158/1535-7163.MCT-12-0869

AUTORES / AUTHORS:  - Hasei J; Sasaki T; Tazawa H; Osaki S; Yamakawa Y; Kunisada T; Yoshida A; Hashimoto Y; Onishi T; Uno F; Kagawa S; Urata Y; Ozaki T; Fujiwara T

INSTITUCIÓN / INSTITUTION:  - 1Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

RESUMEN / SUMMARY:  - Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. p53 overexpression enhances the antitumor activity of oncolytic adenoviruses; however, the molecular mechanism of this occurrence remains unclear. We previously developed a tumor-specific replication-competent oncolytic adenovirus, OBP-301, that kills human osteosarcoma cells, but some human osteosarcoma cells were OBP-301-resistant. In this study, we investigated the antitumor activity of  a p53-expressing oncolytic adenovirus, OBP-702, and the molecular mechanism of the p53-mediated cell death pathway in OBP-301-resistant human osteosarcoma cells. The cytopathic activity of OBP-702 was examined in OBP-301-sensitive (U2OS and HOS) and OBP-301-resistant (SaOS-2 and MNNG/HOS) human osteosarcoma cells. The molecular mechanism in the OBP-702-mediated induction of two cell death pathways, apoptosis and autophagy, was investigated in OBP-301-resistant osteosarcoma cells. The antitumor effect of OBP-702 was further assessed using an orthotopic OBP-301-resistant MNNG/HOS osteosarcoma xenograft tumor model. OBP-702 suppressed the viability of OBP-301-sensitive and OBP-301-resistant osteosarcoma  cells more efficiently than OBP-301 or a replication-deficient p53-expressing adenovirus (Ad-p53). OBP-702 induced more profound apoptosis and autophagy when compared with OBP-301 or Ad-p53. E1A-mediated miR-93/106b upregulation induced p21 suppression, leading to p53-mediated apoptosis and autophagy in OBP-702-infected cells. p53 overexpression enhanced adenovirus-mediated autophagy through activation of damage-regulated autophagy modulator (DRAM). Moreover, OBP-702 suppressed tumor growth in an orthotopic OBP-301-resistant MNNG/HOS xenograft tumor model. These results suggest that OBP-702-mediated p53 transactivation is a promising antitumor strategy to induce dual apoptotic and autophagic cell death pathways via regulation of miRNA and DRAM in human osteosarcoma cells.

 

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[333]

TÍTULO / TITLE:  - Loss of DOG-1 expression associated with shift from spindled to epithelioid morphology in gastric gastrointestinal stromal tumors with KIT and platelet-derived growth factor receptor alpha mutations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Diagn Pathol. 2012 Dec 3. pii: S1092-9134(12)00146-3. doi: 10.1016/j.anndiagpath.2012.10.005.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.anndiagpath.2012.10.005

AUTORES / AUTHORS:  - Agaimy A; Wang LM; Eck M; Haller F; Chetty R

INSTITUCIÓN / INSTITUTION:  - Institute of Pathology, University Hospital, Erlangen, Germany. Electronic address: abbas.agaimy@uk-erlangen.de.

RESUMEN / SUMMARY:  - Most gastric gastrointestinal stromal tumors (GISTs) display spindle cell morphology and coexpress CD117 (KIT), DOG-1, and CD34. Secondary loss of DOG-1 has not been reported. We present two gastric GISTs which showed loss of DOG-1 in the epithelioid component but retained its expression in the minor spindle cell component. Patients were a 67-year-old man and an 80-year-old woman with 4.8-cm and 3.5-cm gastric GISTs harboring mutations in KIT exon 11 (c.1729_1758dup30; p.P577_R586dup) and platelet-derived growth factor receptor alpha (PDGFRA) exon 18 (c.2527_2538del12; p.I843_D846del), respectively. Both were predominantly epithelioid with a minor microscopic spindle cell component (3-12 mm). The spindle cell component was CD117(+)CD34(+)DOG-1(+) in both cases. The epithelioid component in case 1 was CD117(+)CD34(+)DOG-1(-). In case 2, the epithelioid component strongly expressed PDGFRA (dot-like) but lost CD117, CD34, and DOG-1. These cases confirm the immunophenotypic heterogeneity as secondary events in GIST. Loss of DOG-1 in KIT-negative PDGFRA mutants should not preclude diagnosis.

 

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[334]

TÍTULO / TITLE:  - Aggressive squamous cell carcinoma of the oral tongue in a woman with metastatic  giant cell tumor treated with pegylated liposomal Doxorubicin.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncologist. 2012;17(12):1596-7. doi: 10.1634/theoncologist.2012-0429.

            ●● Enlace al texto completo (gratuito o de pago) 1634/theoncologist.2012-0429

AUTORES / AUTHORS:  - Gu P; Wu J; Sheu M; Myssiorek D; Cohen R

INSTITUCIÓN / INSTITUTION:  - NYU Cancer Center, 462 1st Ave, Building C&D, Room 556, New York, New York, USA.  ping.gu@nyumc.org.

 

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[335]

TÍTULO / TITLE:  - Clinicopathological Features and Prognostic Factors of Rectal Gastrointestinal Stromal Tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Surg. 2013 Jan 4.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11605-012-2086-0

AUTORES / AUTHORS:  - Xiao CC; Zhang S; Wang MH; Huang LY; Wu P; Xu Y; Zhu XL; Sheng WQ; Du CY; Shi YQ; Guan ZQ; Cai SJ; Cai GX

INSTITUCIÓN / INSTITUTION:  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China.

RESUMEN / SUMMARY:  - AIM: Rectal gastrointestinal stromal tumor (GIST) was a rare disease. This study  sought to summarize clinicopathological features and prognostic factors of rectal GISTs. METHODS: Clinicopathological characteristics and prognostic factors of rectal GISTs were investigated by reviewing patients undergoing curative resection at the Fudan University Shanghai Cancer Center between 1986 and 2010. RESULTS: Twenty-one patients, 15 male and 6 female, were included. The mean age of onset was 51 years. The most common initial presentation was hematochezia (7 cases). Eleven patients underwent radical resection, and the other 10 received local resection. No lymph node metastases were identified. All cases were positive for CD117. Seventeen patients were classified as high National Institutes of Health (NIH) risk category. The 5-year disease-free survival (DFS)  and overall survival were 33 and 46 %, respectively. Fifteen cases had recurrence postoperatively. Both univariate and multivariate analyses demonstrated the NIH risk category (p = 0.028) and hematochezia symptom (p = 0.014) were independent prognostic factors of the DFS of patients. CONCLUSIONS: Hematochezia was the most common initial symptom. Over 50 % of patients received radical surgery. More than 80 % of patients were at high NIH risk of recurrence. Hematochezia symptom and high NIH risk category indicated poor prognosis of rectal GISTs.

 

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[336]

TÍTULO / TITLE:  - Ossifying chondrolipoma of the tongue.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Vojnosanit Pregl. 2012 Nov;69(11):1009-12.

AUTORES / AUTHORS:  - Tasic D; Pavlovic M; Stankovic D; Dimov I; Stanojevic G; Dimov D

INSTITUCIÓN / INSTITUTION:  - Institute of Pathology, Faculty of Medicine, University of Nis, Nis, Serbia. desa@medfak.ni.ac.rs

RESUMEN / SUMMARY:  - INTRODUCTION: Chondrolipomas and osteolipomas are uncommon variants of lipomatous tumors. CASE REPORT: We presented a 60-year-old woman with ossifying chondrolipoma of the tongue. Clinical examination revealed a firm nodular mass, located in the midline of the posterior region on the dorsal surface of the tongue. Histologically, the lesion was well-delimited showing areas of mature adipocytes arranged in lobules and separated by fibrous connective tissue septa,  islands of mature cartilaginous tissue and osseous metaplasia. Trabeculae of lamellar bone within a fibro-fatty background were visible throughout the tumor.  The cartilaginous areas merging centrally with bone formation and fatty marrow tissue were present, as well as the hematopoietic elements in the fatty marrow. The bone forming was found to be through both membranous and enchondral mechanisms. CONCLUSION: Ossifying chrondrolipoma with hematopoietic elements is extremely unusual lesion. This interesting entity should be kept in mind in the differential diagnosis of lingual lesions.

 

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[337]

TÍTULO / TITLE:  - Somatic stem cells in the myometrium and in myomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Semin Reprod Med. 2013 Jan;31(1):77-81. doi: 10.1055/s-0032-1331801. Epub 2013 Jan 17.

            ●● Enlace al texto completo (gratuito o de pago) 1055/s-0032-1331801

AUTORES / AUTHORS:  - Maruyama T; Ono M; Yoshimura Y

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

RESUMEN / SUMMARY:  - The human uterus mainly consists of two layers: an inner endometrium and an outer layer, the myometrium, made of smooth muscle. The uterus is characterized by its  unique capacity for regeneration. This capacity permits cyclical regeneration and remodeling of the tissue over the course of a woman’s reproductive life. During each menstrual cycle, the endometrium regenerates, and the uterus enlarges to make room for fetal growth. This cyclic physiologic pattern suggests that myometrial stem/progenitor cells are present in the tissue and play a role in myometrial functions. Our group (and others) recently characterized and isolated  putative stem/progenitor cells in the myometrium. These findings are permitting a better understanding of myometrial physiology and pathology. We review current studies of myometrial stem/progenitor cells and suggestions that, in combination  with hypoxia, these cells may contribute to uterine remodeling during pregnancy and the formation of myomas.

 

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[338]

TÍTULO / TITLE:  - The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic  acid binding site.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Biochim Biophys Acta. 2013 Feb;1832(2):375-85. doi: 10.1016/j.bbadis.2012.11.012. Epub 2012 Nov 28.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.bbadis.2012.11.012

AUTORES / AUTHORS:  - Liu X; Niu C; Ren J; Zhang J; Xie X; Zhu H; Feng W; Gong W

INSTITUCIÓN / INSTITUTION:  - National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China.

RESUMEN / SUMMARY:  - Fused in sarcoma (FUS) is involved in many processes of RNA metabolism. FUS and another RNA binding protein, TDP-43, are implicated in amyotrophic lateral sclerosis (ALS). It is significant to characterize the RNA recognition motif (RRM) of FUS as its nucleic acid binding properties are unclear. More importantly, abolishing the RNA binding ability of the RRM domain of TDP43 was reported to suppress the neurotoxicity of TDP-43 in Drosophila. The sequence of FUS-RRM varies significantly from canonical RRMs, but the solution structure of FUS-RRM determined by NMR showed a similar overall folding as other RRMs. We found that FUS-RRM directly bound to RNA and DNA and the binding affinity was in  the micromolar range as measured by surface plasmon resonance and NMR titration.  The nucleic acid binding pocket in FUS-RRM is significantly distorted since several critical aromatic residues are missing. An exceptionally positively charged loop in FUS-RRM, which is not found in other RRMs, is directly involved in the RNA/DNA binding. Substituting the lysine residues in the unique KK loop impaired the nucleic acid binding and altered FUS subcellular localization. The results provide insights into the nucleic acid binding properties of FUS-RRM and  its potential relevance to ALS.

 

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[339]

TÍTULO / TITLE:  - Molecular and clinicopathological analysis of dermatofibrosarcoma protuberans.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Res Pract. 2013 Jan 15;209(1):30-5. doi: 10.1016/j.prp.2012.10.005. Epub 2012 Dec 1.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.prp.2012.10.005

AUTORES / AUTHORS:  - Walluks K; Chen Y; Woelfel C; Yang L; Cui T; Seliger C; Geier C; Knosel T; Hauke S; Petersen I

INSTITUCIÓN / INSTITUTION:  - Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University Jena, Ziegelmuhlenweg 1, 07743 Jena, Germany.

RESUMEN / SUMMARY:  - Dermatofibrosarcoma protuberans (DFSP) is a dermal and subcutaneous tumor of intermediate malignancy. The most remarkable cytogenetic feature of DFSP is the chromosomal translocation t(17;22)(q22;q13), causing a fusion of the platelet-derived growth factor beta chain (PDGFB) gene at 22q13, and the collagen type 1 alpha 1 (COL1A1) at 17q22. The aim of the study was to analyze the molecular characteristic of DFSP in conjunction with histopathological and clinical features. We performed fluorescence in situ hybridization (FISH) and multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) to detect chromosomal translocations and fusion gene transcripts in 16 formalin-fixed, paraffin-embedded DFSP samples. In addition, the amplification of PDGFB was also  evaluated in the 16 DFSP samples by real-time PCR. FISH analysis revealed that all the 16 samples exhibited COL1A1-PDGFB gene fusion. Eleven out of 11 informative cases (100%) showed fusion transcripts by multiplex RT-PCR analysis.  Various exons of the COL1A1 gene were fused with the PDGFB gene. Among them, exon 25 was found to be more frequently involved. Real-time PCR showed that the PDGFB  copy number increase in the DFSP samples was higher than in normal skin tissues (p=0.007). Values of FISH fusion signals and PDGFB DNA analysis were variable between samples, but suggested that increased values might be associated with parameters of tumor progression. Our results confirm that analysis of the COL1A1-PDGFB status by FISH and RT-PCR is a useful tool in the confirmation of a  DFSP diagnosis. In addition, the analysis of PDGFB copy number status may become  a useful diagnostic marker since the gene is a potential target for treatment of  DFSP patients.

 

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[340]

TÍTULO / TITLE:  - Paratesticular myxoid/round cell liposarcoma harboring type 3 DDIT3-FUS fusion gene: Report of a very rare case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Res Pract. 2012 Dec 28. pii: S0344-0338(12)00305-6. doi: 10.1016/j.prp.2012.10.015.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.prp.2012.10.015

AUTORES / AUTHORS:  - Zozumi M; Nakai M; Matsuda I; Hao H; Tsukamoto Y; Shiraishi Y; Nojima M; Yamamoto S; Hirota S

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.

RESUMEN / SUMMARY:  - Myxoid/round cell liposarcomas are rare mesenchymal neoplasms. They preferentially occur in the lower extremity, and most of them have type 1 or type 2 DDIT3-FUS fusion gene. We report here a very rare case of myxoid/round cell liposarcoma of the paratesticular region with type 3 DDIT3-FUS fusion gene. A 46-year-old Japanese man noticed a gradually enlarged intrascrotal mass without pain. Surgical resection of 3.4cmx2.1cm oval mass was carried out, and it was located in the right paratesticular region apart from the spermatic cord and epididymis. Histological examination of the tumor revealed ovoid cell proliferation with anastomosing vascular network and scattered lipoblasts. Genetic analysis elucidated that the tumor had a chromosomal translocation, type  3 DDIT3-FUS chimeric gene. The tumor was definitely diagnosed as myxoid/round cell liposarcoma of the paratesticular region.

 

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[341]

TÍTULO / TITLE:  - Local excision with adjuvant imatinib therapy for anorectal gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Tech Coloproctol. 2013 Jan 30.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10151-013-0976-0

AUTORES / AUTHORS:  - Centonze D; Pulvirenti E; Pulvirenti D’Urso A; Franco S; Cinardi N; Giannone G

INSTITUCIÓN / INSTITUTION:  - Division of Surgical Oncology, Department of Oncology, Ospedale Garibaldi Nesima, Via Palermo 636, 95122, Catania, Italy.

RESUMEN / SUMMARY:  - Rectal gastrointestinal stromal tumors (GISTs) are uncommon, and the role of local excision versus a more extensive resection after the advent of effective targeted chemotherapy with imatinib is not known. Our aim is to present two cases of large anorectal GIST treated with local excision through a new anterolateral trans-sphincteric approach followed by adjuvant therapy with imatinib. Two patients (both males, 68 and 63 years old) presented at our institution with anorectal GIST in the period October-November 2010. Their medical records, pathology results, and imaging studies were retrospectively reviewed. Both patients presented with an anterior perianal mass. Imaging studies were characteristic of GIST originating in the lower rectum, circumscribed by a pseudocapsule, and protruding into the ischiorectal fossa. Both patients underwent local excision via an anterolateral trans-sphincteric approach. Both tumors were removed intact, with microscopically negative margins. The maximum tumor diameter was 8 and 9 cm, and the diagnosis of GIST was confirmed by positive CD117 and CD34 staining in both cases. Both tumors had a high (>5/50HPF) mitotic index. The patients had an uneventful postoperative course and were discharged on days 5 and 6. Both patients were started on imatinib 400 mg bid postoperatively. Postoperative magnetic resonance imaging and positron emission tomography computed tomography were carried out at 12 months and did not reveal any signs of recurrence. The patients are currently disease-free at 24 and 23 months of follow-up. In selected cases, complete excision of rectal GIST with negative margins is feasible via a trans-sphincteric approach. With the use of adjuvant therapy, which is currently advocated in all high-risk cases, it is possible that local excision with its reduced morbidity may become a viable alternative, especially in patients who would otherwise require abdominoperineal  excision such as the two presented here. Prospective studies with longer follow-up are needed to confirm adequate oncologic results.

 

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[342]

TÍTULO / TITLE:  - Ovarian Fibromatosis and Sotos Syndrome with a New Genetic Mutation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Adolesc Gynecol. 2013 Jan 15. pii: S1083-3188(12)00247-1. doi: 10.1016/j.jpag.2012.11.012.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpag.2012.11.012

AUTORES / AUTHORS:  - Beurdeley M; Sabourin JC; Drouin-Garraud V; Liard A; Bachy B; Vivier PH

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Surgery, Clinique chirurgicale et infantile, CHU Charles  Nicolle, Rouen, France. Electronic address: marion.beurdeley@gmail.com.

RESUMEN / SUMMARY:  - BACKGROUND: Sotos syndrome is one the most common overgrowth conditions, after Beckwith-Wiedemann syndrome. As with other overgrowth syndromes, Sotos syndrome can be associated with an increased risk of tumors. CASE: We describe a young girl with Sotos syndrome and ovarian fibromatosis with a new mutation not reported before in the literature. SUMMARY AND CONCLUSION: Development of ovarian tumor in Sotos syndrome has been poorly documented. Ovarian fibromatosis is a very rare non neoplastic disease. Management is guided by the benignity of the lesion and consists of surgical excision of the fibroma.

 

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[343]

TÍTULO / TITLE:  - Adult Inflammatory Myofibroblastic Tumor of the Trachea: Case Report and Literature Review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Respir Care. 2012 Dec 18.

            ●● Enlace al texto completo (gratuito o de pago) 4187/respcare.02198

AUTORES / AUTHORS:  - Oztuna F; Pehlivanlar M; Abul Y; Tekinbas C; Ozoran Y; Ozlu T

INSTITUCIÓN / INSTITUTION:  - Karadeniz Technical University Faculty of Medicine Department of Pulmonary Medicine Trabzon, Turkey.

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumor of the trachea is a rare benign tumor of the adult. It is mostly seen before the age of 16. We describe a 20-year-old female patient who presented with stridor. She had a fixed obstruction on spirometry and a thorax computed tomography and bronchoscopy confirmed the presence of tracheal  thickening and stenosis below the vocal cords and bronchial wall thickening at the level of carina. Bronchoscopic biopsies confirmed the lesion to be an inflammatory myofibroblastic tumor. After mechanical dilatation and resection by  rigid bronchoscopy and corticosteroid therapy, the clinical status of the patient was relieved.

 

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[344]

TÍTULO / TITLE:  - Genetic and pathologic evolution of early secondary gliosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Brain Tumor Pathol. 2013 Jan 17.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10014-012-0132-y

AUTORES / AUTHORS:  - Codispoti KE; Mosier S; Ramsey R; Lin MT; Rodriguez FJ

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Johns Hopkins University, Baltimore, USA.

RESUMEN / SUMMARY:  - Gliosarcoma is a subset of glioblastoma with glial and mesenchymal components. True secondary gliosarcomas (i.e. progressing from lower-grade precursors) in the absence of radiation therapy are very rare. We report the unique case of a 61-year-old male who developed a fibrillary astrocytoma (WHO grade II). In the absence of adjuvant therapy the tumor recurred 3 years later as a gliosarcoma comprising an infiltrating glial component and a curious, early high-grade sarcomatous component surrounding intratumoral vessels. DNA was extracted from formalin fixed paraffin-embedded tissues from the precursor low-grade glioma and  from the glioma and sarcomatous components at progression. Samples were hybridized separately to a 300 k Illumina SNP array. IDH1(R132H) mutant protein immunohistochemistry was positive in all tissue components. Alterations identified in all samples included dup(1)(q21q41), del(1)(q41qter), del(2)(q31.1), del(2)(q36.3qter), del(4)(q35.1qter), dup(7)(q22.2q36.3), del(7)(q36.3qter), del(9)(p21.3pter), dup(10)(p13pter), del(10)(q26.13q26.3), dup(17) (q12qter), and copy neutral LOH(20)(p11.23p11.21). The recurrent tumor had additional alterations, including del(3)(p21.31q13.31), del(18)(q21.2qter), and a homozygous del(9)(p21.3)(CDKN2A locus) and the sarcoma component had, in addition, del(4)(p14pter), del(6)(q12qter), del(11)(q24.3qter), and del(16)(p11.2pter). In conclusion, unique copy number alterations were identified during tumor progression from a low-grade glioma to gliosarcoma. A subset of alterations developed specifically in the sarcomatous component.

 

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[345]

TÍTULO / TITLE:  - Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Reprod Biol Endocrinol. 2012 Dec 17;10(1):111.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7827-10-111

AUTORES / AUTHORS:  - Iwahashi M; Muragaki Y; Ino K

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: To investigate the role of prolyl hydroxylase (PH), a key enzyme of collagen synthesis, in human uterine leiomyoma, PH expression was determined in the normal uterine myometrium and the leiomyoma tissues during the  menstrual cycle. METHODS: The tissues were obtained from 40 regularly cycling women (aged 29 to 53 yr) who were undergoing abdominal hysterectomy for symptomatic uterine leiomyoma. Immunohistochemistry for human PH with specific monoclonal antibody was used for analysis. RESULTS: Immunohistochemical staining  for PH revealed intense staining of leiomyoma cells in the uterine leiomyoma throughout the menstrual cycle, as compared with the adjacent normal myometrium.  In the secretory phase, weak or no immunostaining for PH was detected in the normal myometrial tissues. CONCLUSIONS: These results suggest that increased expression of PH might play an role in the physiology of uterine leiomyoma during the menstrual cycle.

 

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[346]

TÍTULO / TITLE:  - Children’s Oncology Group’s 2013 blueprint for research: Soft tissue sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2012 Dec 19. doi: 10.1002/pbc.24435.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24435

AUTORES / AUTHORS:  - Hawkins DS; Spunt SL; Skapek SX

INSTITUCIÓN / INSTITUTION:  - Seattle Children’s Hospital, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington. doug.hawkins@seattlechildrens.org.

RESUMEN / SUMMARY:  - In the US, approximately 850-900 children are diagnosed each year with soft tissue sarcomas (STS). Key findings from recent Children’s Oncology Group (COG) clinical trials include safe reduction in therapy for low risk rhabdomyosarcoma (RMS), validation of FOXO1 fusion as a prognostic factor, a modest improvement in outcome for high-risk RMS, and a biologically designed non-cytotoxic therapy for  pediatric desmoid tumor. Planned Phase 2 trials include targeted agents for VEGF/PDGF, mTOR, and IGF-1R for children with RMS and VEGF for children with non-RMS STS (NRSTS). For RMS, COG Phase 3 trials potentially will explore VEGF/mTOR inhibition or chemotherapy interval compression. For NRSTS, a COG Phase 3 trial will explore VEGF inhibition. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc.

 

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[347]

TÍTULO / TITLE:  - Effects of transforming growth factor-beta1 on cell motility, collagen gel contraction, myofibroblastic differentiation, and extracellular matrix expression of human adipose-derived stem cell.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Cell. 2012 Dec;25(4):87-95. doi: 10.1007/s13577-012-0049-0. Epub 2012 Dec 16.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13577-012-0049-0

AUTORES / AUTHORS:  - Kakudo N; Kushida S; Suzuki K; Ogura T; Notodihardjo PV; Hara T; Kusumoto K

INSTITUCIÓN / INSTITUTION:  - Department of Plastic and Reconstructive Surgery, Kansai Medical University, 10-15 Fumizono, Moriguchi, Osaka, 570-8506, Japan, kakudon@takii.kmu.ac.jp.

RESUMEN / SUMMARY:  - Human adipose-derived stem cells (ASCs) are adult pluripotent stem cells, and their usefulness in plastic surgery has garnered attention in recent years. Although, there have been expectations that ASCs might function in wound repair and regeneration, no studies to date have examined the role of ASCs in the mechanism that promotes wound-healing. Transforming growth factor-beta1 (TGF-beta1) is a strong candidate cytokine for the triggering of mesenchymal stem cell migration, construction of extracellular matrices, and differentiation of ASCs into myofibroblasts. Cell proliferation, motility, and differentiation, as well as extracellular matrix production, play an important role in wound-healing. We have evaluated the capacity of ASCs to proliferate and their potential to differentiate into phenotypic myofibroblasts, as well as their cell motility and  collagen gel contraction ability, when cultured with TGF-beta1. Cell motility was analyzed using a wound-healing assay. ASCs that differentiated into myofibroblasts expressed the gene for alpha-smooth muscle actin, and its protein  expression was detected immunohistochemically. The extracellular matrix expression in ASCs was evaluated using real-time RT-PCR. Based on the results, we conclude that human ASCs have the potential for cell motility, extracellular matrix gene expression, gel contraction, and differentiation into myofibroblasts  and, therefore, may play an important role in the wound-healing process.

 

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[348]

TÍTULO / TITLE:  - The role of dynamic contrast-enhanced MRI in differentiation of local recurrence  and residual soft-tissue tumor versus post-treatment changes.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bratisl Lek Listy. 2013;114(2):88-92.

AUTORES / AUTHORS:  - Lehotska V; Tothova L; Valkovic L

RESUMEN / SUMMARY:  - Objectives: To evaluate the reliability of dynamic contrast-enhanced MRI in the diagnosis of local recurrence of malignant soft-tissue tumors after receiving treatment. Methods: From March 2002 till December 2009 we performed dynamic contrast enhanced MRI in 95 patients with soft-tissue tumor after receiving treatment (surgery, radiotherapy, chemotherapy). Patients were classified according to five types of TIC.Results: The recurrent disease was suspected in 47 patients and the biopsy was recommended. In 8 cases (TIC II), the biopsy was performed due to long-term post-treatment changes. Histological results proved STT recurrence in 45 patients; in 10 patients (8 with TIC II), biopsy revealed hypervascular granulation tissue, florid inflammation and reactive changes. The sensitivity for dynamic contrast-enhanced MR examination was 100 %, specificity 80 %, positive predictive value (PPV) 95.7 % and negative predictive value (NPV)  100 %.Conclusion: Our results indicate that TICs III, IV and V raise high suspicion of local tumor recurrence and require percutaneous imaging-guided biopsy. TIC of type II usually represents a pseudomass and the biopsy should be performed only in selected cases with increased risk of recurrent disease based on multidisciplinary approach. On the basis of literature review as well as our experiences we created a reliable algorithm proposed for diagnosing the residual  or recurrent soft-tissue tumors (Tab. 2, Fig. 6, Ref. 20). Keywords: soft-tissue  neoplasms, residual tumor, magnetic resonance imaging.

 

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[349]

TÍTULO / TITLE:  - Specificity of TLE1 Expression in Unclassified High-grade Sarcomas for the Diagnosis of Synovial Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Appl Immunohistochem Mol Morphol. 2012 Nov 28.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAI.0b013e318279f9ee

AUTORES / AUTHORS:  - Valente AL; Tull J; Zhang S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, SUNY Upstate Medical University, Syracuse, NY.

RESUMEN / SUMMARY:  - Expression of the transducin-like enhancer of split 1 (TLE1) by immunohistochemistry (IHC) has been widely used as a biomarker for the diagnosis  of synovial sarcoma. Although TLE1 expression can be identified in more than 90%  of synovial sarcomas, positive staining has been reported in up to one third of nonsynovial sarcomas, including peripheral nerve sheath tumors and neoplasms of fibrous and adipose tissues. The low specificity of this test in soft tissue tumors raises concern on its clinical application as a diagnostic biomarker. As synovial sarcoma is frequent among the differential diagnosis of unclassified high-grade sarcomas, and considering that the specificity of TLE1 antibody in this tumor group remains unclear, we evaluated TLE1 expression by IHC in 42 unclassified high-grade sarcomas. SS18 (SYT) gene break-apart analyses by fluorescence in situ hybridization were simultaneously performed as a gold standard biomarker for synovial sarcoma. Five cases that were positive for the SS18 break-apart by fluorescence in situ hybridization were also positive for TLE1 by IHC, whereas the remaining 37 cases negative for SS18 break-apart were all negative for TLE1. The results showed no evidence of nonspecific TLE1 expression in the nonsynovial high-grade sarcomas. We concluded that TLE1 is a highly specific biomarker for synovial sarcoma in the setting of differential diagnosis of unclassified high-grade sarcomas.

 

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[350]

TÍTULO / TITLE:  - Management of dental complications in a child with rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Dent. 2012;34(7):506-9.

AUTORES / AUTHORS:  - Jalali G; Unkel JH; Reed JA

INSTITUCIÓN / INSTITUTION:  - Jacobi Medical Center, New York City, N.Y., USA.

RESUMEN / SUMMARY:  - Radiotherapy treatment options can cause adverse dental sequelae, including xerostomia, dental radiation caries, abnormal tooth development, and osteoradionecrosis (ORN). Hyperbaric oxygen (HBO) therapy can be used prophylactically or therapeutically to treat or reduce the risk of ORN. The purpose of this paper was to describe a case involving a 5-year-old male with rhabdomyosarcoma of the left temporal fossa and a history of radiation therapy who presented with gross radiation caries and xerostomia. Full-mouth extractions  of all primary teeth were performed under general anesthesia, with the patient receiving HBO therapy before and after the surgery. The child was monitored postoperatively, and healing occurred with minimal post-operative complications.  Based on his results, it can be concluded that hyperbaric oxygen therapy is an effective supplement to consider when treating children who have undergone radiation therapy and require dental care.

 

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[351]

TÍTULO / TITLE:  - Serous cystadenofibroma of the ovary.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Obstet Gynaecol Can. 2012 Nov;34(11):1017.

AUTORES / AUTHORS:  - Vilos AG; Vilos GA; Marks J; Chan C

INSTITUCIÓN / INSTITUTION:  - Minimally Invasive Gynecology (MIG), Department of Obstetrics and Gynecology, The University of Western Ontario, London ON.

 

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[352]

TÍTULO / TITLE:  - Angioleiomyoma of the oral cavity extended to submandibular space; an unusual tumor in an unusual deep-seated space: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Rev Med Pharmacol Sci. 2012 Oct;16 Suppl 4:134-7.

AUTORES / AUTHORS:  - Minni A; De Carlo A; Roukos R; Illuminati G; Cerbelli B

INSTITUCIÓN / INSTITUTION:  - Department of Sensory Organs, Sapienza University of Rome, Rome, Italy. antonio.minni@uniroma1. com

RESUMEN / SUMMARY:  - Angioleiomyoma (AL) is a benign neoplasia originating from smooth muscle and very uncommon in the oral cavity. The most frequent subtype in the oral cavity is the  vascular one. AL usually occurs in the extremities: only around 12% are found in  other areas such as head and neck. It presents as an asymptomatic, slow growing nodule lodging in the palate, tongue or lips. The diagnosis is essentially by histological exam and special specific stains are helpful to confirm the origin and to distinguish it from other tumors. We present a case of AL found in unusual site: attached to the submandibular region in a deep-seated space.

 

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[353]

TÍTULO / TITLE:  - The management of children with Kaposi sarcoma in resource limited settings.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2012 Dec 19. doi: 10.1002/pbc.24408.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24408

AUTORES / AUTHORS:  - Molyneux E; Davidson A; Orem J; Hesseling P; Balagadde-Kambugu J; Githanga J; Israels T

INSTITUCIÓN / INSTITUTION:  - Paediatric Department, College of Medicine, University of Malawi, Blantyre, Malawi. emmolyneux@gmail.com.

RESUMEN / SUMMARY:  - Kaposi sarcoma (KS) is common where HIV infection is endemic. Antiretroviral therapy (ART) has reduced the incidence in well-resourced settings but in some parts of the world access to ART is delayed. These recommendations are for use where only minimal requirements for treatment are available. Consensus was sought for the management of childhood HIV-associated KS in this setting. There are no randomised controlled studies of chemotherapy for KS in children and these recommendations have drawn on consensus of a group of experts and published reports from studies in adults. Pediatr Blood Cancer © 2012 Wiley Periodicals,  Inc.

 

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[354]

TÍTULO / TITLE:  - Case Report: Curetting Osteoid Osteoma of the Spine Using Combined Video-assisted Thoracoscopic Surgery and Navigation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Orthop Relat Res. 2013 Feb;471(2):680-5. doi: 10.1007/s11999-012-2725-5. Epub 2012 Dec 5.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11999-012-2725-5

AUTORES / AUTHORS:  - Campos WK; Gasbarrini A; Boriani S

INSTITUCIÓN / INSTITUTION:  - Department of Oncologic and Degenerative Spine Surgery, Rizzoli Orthopedic Institute - Bologna, Italy, Via G.C. Pupilli, 1-40136, Bologna, Italy, wuilker@yahoo.com.br.

RESUMEN / SUMMARY:  - BACKGROUND: A spinal osteoid osteoma is a rare benign tumor. The usual treatment  involves complete curettage including the nidus. In the thoracic spine, conventional open surgical treatment usually carries relatively high surgical risks because of the close anatomic relationship to the spinal cord, nerve roots, and thoracic vessels, and pulmonary complications and postoperative pain. CASE REPORT: We report the case of a 16-year-old girl with a symptomatic osteoid osteoma at the T9 level whose lesion was currettaged using video-assisted thoracoscopic surgery (VATS) guided by a navigation system (VATS-NAV). There were no complications and the patient had immediate relief of the characteristic pain  after surgery and was asymptomatic at 5 months’ followup. LITERATURE REVIEW: Progressive advances in the technology of spinal surgery have evolved to offer greater safety and less morbidity for patients. The advent of minimally invasive  surgery has expanded the indications for VATS for anterior spinal disorders. Spinal navigation systems have become useful tools allowing localization and excision of the nidus of osteoid osteomas with minimal bone resection and without radiation exposure. CLINICAL RELEVANCE: The VATS-NAV combination in our patient allowed accurate localization and guidance for complete excision of a spinal osteoid osteoma through a minimally invasive approach without compromising spinal stability.

 

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[355]

TÍTULO / TITLE:  - Targeting the fetal acetylcholine receptor in rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Expert Opin Ther Targets. 2013 Feb;17(2):127-38. doi: 10.1517/14728222.2013.734500. Epub 2012 Dec 11.

            ●● Enlace al texto completo (gratuito o de pago) 1517/14728222.2013.734500

AUTORES / AUTHORS:  - Simon-Keller K; Barth S; Vincent A; Marx A

INSTITUCIÓN / INSTITUTION:  - University Medical Centre Mannheim, University of Heidelberg, Institute of Pathology , Theodor-Kutzer-Ufer 1-3, D-68135 Mannheim , Germany +49 621 383 5953  ; +49 621 383 2005 . katja.simon-keller@medma.uni-heidelberg.de.

RESUMEN / SUMMARY:  - Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence. Recent efforts to enhance overall survival of patients with clinically advanced RMS have failed and there is a demand for conceptually novel treatments. Immune therapeutic options targeting the fetal nicotinic acetylcholine receptor (fnAChR), which is broadly expressed on RMS, are novel approaches to overcome the therapeutic resistance of RMS. Expression of the fnAChR is restricted to developing fetal muscles, some apparently dispensable ocular muscle fibers and thymic myoid cells. Therefore, after-birth fnAChR is a tumor-associated and almost tumor-specific antigen on RMS cells. Areas covered: This review gives an overview on nAChR function and expression pattern in RMS tumor cells, and deals with the immunological significance of fnAChR-expressing cells, including the risk of anti-nAChR autoimmunity as a potential side effect of fnAChR-directed immunotherapies. The article also addresses the advantages and disadvantages of vaccination strategies, immunotoxins and chimeric T cells targeting the fnAChR. Expert opinion: Finally, we suggest technical and biological strategies to improve the available immunotherapeutic tools including  increasing the in vivo expression of the target fnAChR on RMS cells.

 

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[356]

TÍTULO / TITLE:  - Pediatric giant cell fibroma: an unusual case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Dent. 2012;34(7):503-5.

AUTORES / AUTHORS:  - Uloopi KS; Vinay C; Deepika A; Sekhar RC; Raghu D; Ramesh T

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Dentistry, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.

RESUMEN / SUMMARY:  - Giant cell fibroma (GCF) is a lesion of oral mucosa which is commonly found on gingiva. The prevalence of GCF is high in Caucasians in the first three decades.  It represents 2% to 5% of all fibrous lesions. This report describes a case of GCF on the tongue in a 12 year old Dravidian child. The cause of the lesion could not be determined. Excisional biopsy was performed to establish definitive diagnosis. Microscopically, numerous stellate shaped multi-nucleated giant cells  and dense bundles of collagen fibres with a whorled pattern were observed. These  collagen fibres were positive for Massons trichrome stain. Immunohistochemical analysis showed stellate cells positive for vimentin and negative for alpha smooth muscle actin suggesting fibroblast phenotype. No recurrence was observed.  Pediatric dentists must have a thorough knowledge of this uncommon lesion which can be diagnosed only based on histopathological features.

 

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[357]

TÍTULO / TITLE:  - Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: sclerotic (fibroma-like) lipoma, dorsum of right hand.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Adv Anat Pathol. 2013 Jan;20(1):68-72. doi: 10.1097/PAP.0b013e31827b65e3.

            ●● Enlace al texto completo (gratuito o de pago) 1097/PAP.0b013e31827b65e3

AUTORES / AUTHORS:  - Allen PW

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Pathology, SA Pathology, Flinders Medical Centre, SA, Australia. phil.allen@health.sa.gov.au

RESUMEN / SUMMARY:  - Approximately 26 sclerotic lipomas have been reported since Zelger and colleagues’ 1997 report of 5 cases involving the scalp and hands. In 2006, Laskin and colleagues published 21 sclerotic lipomas in a study restricted to tumors of  the hands and feet. Patients’ ages ranged from 7 to 72 years (mean and median 39  y); there were 12 males and 9 females; the masses, which were mostly asymptomatic and solitary, ranged from 0.6 to 2.2 cm (median 1.2 cm, mean 1.3 cm) and involved fingers (N=17), hands or wrists (N=3), and toes (N=1). Microscopically, lesions were well circumscribed, of low cellularity, and consisted of cytologically bland spindle and stellate-shaped cells with a minor component of randomly dispersed adipocytes embedded in a collagenous to myxocollagenous stroma. Eight tumors were fibroma-like with dense fibrosclerotic stroma and inconspicuous blood vessels. One tumor exhibited features of spindle cell/pleomorphic lipoma, whereas another  displayed a vague onion skin-like arrangement of collagen reminiscent of a sclerotic (storiform) fibroma. The mitotic activity was negligible. Nonlipogenic  cells were immunoreactive for CD99 (6/6) CD34 (6/8), S100 (4/7), and smooth muscle actin (2/6). Follow-up on 8 patients (range, 1 to 20 y, median 9.5 y) revealed no recurrence in 6 and possible persistent tumor in 2 after simple excision. The slide circulated to club members was from a 35-mm tumor on the dorsum of the right hand of a male aged 75. Club members generally agreed with a  diagnosis of sclerotic lipoma but opinions differed as to whether it is a specific entity or a variant of spindle cell lipoma or dendritic fibromyxolipoma.

 

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[358]

TÍTULO / TITLE:  - Myxoid Tumor Associated to Migration of a Suspensory Fixation Device of a Reconstructed Anterior Cruciate Ligament: A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Knee Surg. 2012 May 3.

            ●● Enlace al texto completo (gratuito o de pago) 1055/s-0031-1299649

AUTORES / AUTHORS:  - Gelber PE; Erquicia JI; Pelfort X; Tey M; Monllau JC

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Hospital de Sant Pau, Universitat Autonoma de  Barcelona, Barcelona, España.

RESUMEN / SUMMARY:  - A 16-year-old male who had undergone 6 months before an anterior cruciate ligament (ACL) reconstruction with an autologous hamstring graft fixed with a suspensory fixation device (XoButton device; ConMed Linvatec, Largo, FL), complained of a slightly painful mass in the distal posterolateral aspect of the  thigh. The knee was otherwise stable. A 79 x 60 x 17 mm multilobulated tumor surrounding the implant device was observed in magnetic resonance images. The revision arthroscopy showed an intact ACL graft. The tumor was excised through a  longitudinal posterolateral approach. It had a myxoid appearance. The undamaged implant was also removed. Two months after surgery, the patient was already asymptomatic. Although most fixation device problems occur in the perioperative period due to an inadequate technique which may lead to graft instability, this case reminds clinicians of the possibility of later developing clinically relevant complications with suspensory fixation devices.

 

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[359]

TÍTULO / TITLE:  - Endobronchial Malignant Fibrous Histiocytoma: A Case Report of an Unusual Presentation and Palliative Flexible Bronchoscopic Resection.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Respir Care. 2012 Dec 18.

            ●● Enlace al texto completo (gratuito o de pago) 4187/respcare.01996

AUTORES / AUTHORS:  - Kim JH; Cho SH; Kim EK; Lee JH; Jeong HC

INSTITUCIÓN / INSTITUTION:  - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Pathology, CHA Bundang Medical Center, College of Medicine, CHA University, Seongnam, Korea.

RESUMEN / SUMMARY:  - Primary malignant fibrous histiocytoma (MFH) of the lung is a very rare neoplasm, which usually presents as a parenchymal mass. Here, we report an unusual case of  primary MFH of the bronchus showing relatively benign clinical features. We performed a palliative resection via flexible bronchoscopy using a polypectomy snare. The patient has survived for over 2 years of being diagnosed with an endobronchial mass, later found to be MFH, and 14 months post-debulking. There is a possibility that endobronchial MFH has a more favorable prognosis than MFH of other origins. If this is true, interventional bronchoscopy can be a reasonable option for non-operable cases of MFH.

 

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[360]

TÍTULO / TITLE:  - Comparison of PET-CT and conventional imaging in staging pediatric rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2012 Dec 19. doi: 10.1002/pbc.24430.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24430

AUTORES / AUTHORS:  - Federico SM; Spunt SL; Krasin MJ; Billup CA; Wu J; Shulkin B; Mandell G; McCarville MB

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee; Department of Pediatrics, The University of Tennessee, College of Medicine, Memphis, Tennessee. sara.federico@stjude.org.

RESUMEN / SUMMARY:  - BACKGROUND: Over the past decade, PET-CT has been used to assess rhabdomyosarcoma (RMS) in children. However, the role of PET-CT in staging RMS is unknown. PROCEDURE: Thirty subjects with RMS, median age 7.3 years, underwent PET-CT before therapy. PET-CTs and conventional imaging (CI) were independently reviewed by two radiologists and two nuclear medicine physicians to determine the presence of metastases. Accuracy, sensitivity, and specificity of PET-CT for detecting metastases were compared to CI using biopsy and clinical follow-up as reference standards. Maximum standardized uptake values (SUV(max) ) of primary tumors, lymph nodes, and pulmonary nodules were measured. RESULTS: Primary tumors had an  average SUV(max) of 7.2 (range, 2.5-19.2). Accuracy rates for 17 subjects with nodal disease were 95% for PET-CT and 49% for CI. PET-CT had 94% sensitivity and  100% specificity for nodal disease. Of seven pulmonary nodules detected by CI, three were not identified by PET-CT, two were indeterminate, and one was malignant with a SUV(max) (3.4) > twice that of benign nodules. Two subjects had  bone disease; both were identified by PET-CT but only one by CI. Four subjects had bone marrow disease, two had positive PET-CTs but none had positive CI. Two subjects had soft tissue metastases detected by PET-CT but not CI. CONCLUSIONS: PET-CT performed better than CI in identifying nodal, bone, bone marrow, and soft tissue disease in children with RMS. CI remains essential for detection of pulmonary nodules. We recommend PET-CT for staging of children with RMS. CI with  Tc(99m) bone scan can be eliminated. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc.

 

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[361]

TÍTULO / TITLE:  - Reporting an unusual case of mesenteric desmoid tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Liban. 2012 Jul-Sep;60(3):176-81.

AUTORES / AUTHORS:  - Haddad J; Alam H; Keriakos K; Azzi M

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, Sacre-Coeur Hospital, Hazmieh, Lebanon. johnny.haddad@gmail.com

RESUMEN / SUMMARY:  - A 51-year-old male patient with no history of medical illnesses presented to the  emergency department with abdominal pain and a temperature of 39 degrees Celsius. His condition deteriorated rapidly within a few hours. Clear signs of acute abdomen, raised white blood cell count and small gas-fluid levels on abdominal X  ray prompted an urgent CT scan of the abdomen. The latter revealed a space occupying lesion arising from the central mesentery containing gas-fluid levels measuring approximately 9 x 9 cm. An urgent exploratory laparotomy was performed. This revealed a mesenteric mass measuring 10 x 10 cm with an abscess. Anatomopathologic investigations showed a mesenteric desmoid tumor. Both colonoscopy and gastroscopy were within normal range ruling out Gardner’s syndrome with no polyps or other lesions. The patient made full recovery with radical surgery. This is to our knowledge the fifth case of a desmoid tumor presenting with abdominal abscess not associated with familial adenomatous polyposis. We therefore believe this is an important finding to report.

 

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[362]

TÍTULO / TITLE:  - Giant Extra-articular Synovial Osteochondromatosis of the Sinus Tarsi-A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Foot Ankle Surg. 2013 Jan 11. pii: S1067-2516(12)00548-0. doi: 10.1053/j.jfas.2012.11.017.

            ●● Enlace al texto completo (gratuito o de pago) 1053/j.jfas.2012.11.017

AUTORES / AUTHORS:  - Kim SR; Shin SJ; Seo KB; Teong CT; Hyun CL

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Jeju National University College of Medicine,  Jeju, Korea.

RESUMEN / SUMMARY:  - A 32-year-old male presented with painful swelling of the sinus tarsi that occurred during daily activities. Diagnostic imaging suggested the presence of a  large synovial osteochondromatosis that blocked subtalar motion with deformity of the adjacent bone. The large bony mass was excised, and normal subtalar motion was achieved.

 

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[363]

TÍTULO / TITLE:  - Malignant solitary fibrous tumour of the chest wall: a challenging case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Rev Med Pharmacol Sci. 2012 Oct;16 Suppl 4:21-5.

AUTORES / AUTHORS:  - Novellis P; Cesario A; Lococo F; Cafarotti S; Porziella V; Meacci E; Vita ML; Congedo MT; Ricci R; Margaritora S; Granone P

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, Catholic University of the Sacred Heart, Rome, Italy.

RESUMEN / SUMMARY:  - Solitary fibrous tumors are very rare neoplasms that seldomly appear in extra-serosal soft tissues. In such cases, an accurate preoperative diagnosis is  often difficult and challenging, especially in extrapleural ones. Traditionally,  extrapleural solitary fibrous tumours have been regarded as indolent neoplasms similar to their intra-thoracic counterparts, although there has been some evidence that this subgroup could be a subset of more aggressive malignant tumours. For these reasons, surgical excision is mandatory and represents, to date, the best therapeutic option. In this article we report a case of a malignant solitary fibrous tumor of the chest wall in a 58-year-old man. Problems related to differential diagnosis and the possible pitfalls that can be encountered in the diagnostic process of such rare tumors are discussed.

 

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[364]

TÍTULO / TITLE:  - The Classic: Case of Osteo-Sarcoma of Tibia, Recurring in Stump of Thigh, and Probably Affecting the Lung.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Orthop Relat Res. 2012 Dec 11.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11999-012-2732-6

AUTORES / AUTHORS:  - Ewens J

INSTITUCIÓN / INSTITUTION:  - Surgeon to the Hospital for Sick Children, Bristol, UK, eic@clinorthop.org.

RESUMEN / SUMMARY:  - This Classic article is a reprint of the original work by Mr. John Ewens, “Case of Osteo-Sarcoma of Tibia, Recurring in Stump of Thigh, and Probably Affecting the Lung.” The case is of interest, because the findings contradicted an existing idea, “that large malignant growths, springing from the long bones, do not, after amputation, if the whole of the diseased structures be removed, return in the stump, but at some distant part; and, therefore, it is not necessary to amputate  above the knee in the case of the tibia, or at the hip-joint in the case of the femur.” In Mr. Ewen’s case, an osteosarcoma of the tibia was treated with above-the-knee amputation, but, in fact, it recurred in the stump. The mechanism  was unclear but could have arisen from the presence of a multifocal lesion in the femur, seeding at the time of amputation (details of the amputation were not provided, although the site of the tumor was apparently not involved), or perhaps subsequent metastasis from elsewhere to the stump. Mr. Ewens was a surgeon at the Hospital for Sick Children in Bristol, England. (No other information on Mr. Ewens could be located, and we have no accompanying biographical sketch.) The Classic Article is © (1878) and is reprinted from Ewens J. Case of Osteo-Sarcoma of Tibia, Recurring in Stump of Thigh, and Probably Affecting the Lung. Brit Med J. 1878; Feb 9;1(893):192-193.

 

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[365]

TÍTULO / TITLE:  - Inflammatory myofibroblastic tumour of the liver. Case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Gastroenterol Latinoam. 2012 Sep;42(3):220-3.

AUTORES / AUTHORS:  - Olvera K; Barahona-Garrido J; Alfaro De-Leon A; Tellez-Avila FI; Vilatoba M; Yamamoto-Furusho JK

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumour (IMT), also called inflammatory pseudotumour, is an uncommon neoplastic benign lesion histopathologically characterized by fibroblast and myofibroblast proliferation, with inflammatory cell infiltration.  Systemic inflammatory response can appear although specific pathogens are rarely  found. We present a case of a woman in whom liver abscess was initially suspected The absence of microorganisms in the tissue obtained by needle aspiration biopsy  and the lack of antibiotic therapy response indicated hepatic resection that lead to diagnosis of IMT of the liver, which has to be differentiated from abscess and abscessed tumours. The aim of this case report is to analyze the clinical presentation, course, diagnostic methods, therapies, and existing evidence of the possible pathogenic mechanisms leading to this neoplasm.

 

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[366]

TÍTULO / TITLE:  - Intradural extramedullary spinal nerve sheath myxoma: a report of two cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Brain Tumor Pathol. 2013 Jan 11.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10014-012-0131-z

AUTORES / AUTHORS:  - Yamato M; Ikota H; Hanakita J; Iizuka Y; Nakazato Y

INSTITUCIÓN / INSTITUTION:  - Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

RESUMEN / SUMMARY:  - Nerve sheath myxoma, a myxoid variant of schwannoma, is a dermal tumor that usually occurs in the upper extremities, head and neck region, or trunk; occasionally, however, it has also been reported to develop in the spinal canal.  Here, we describe two cases of intraspinal nerve sheath myxoma. Case 1 was a 74-year-old man with left hypochondrial pain. Gadolinium-enhanced magnetic resonance imaging (MRI) of his spine revealed a well-demarcated intradural extramedullary tumor with peripheral enhancement at the Th8 level. Case 2 was a 58-year-old man with lower back and left buttock pain. Gadolinium-enhanced MRI revealed a well-demarcated intradural extramedullary tumor with peripheral enhancement at the Th12-L1 level. Both cases were clinically diagnosed as schwannoma. Histological studies revealed characteristic myxoid lobules which were separated by fibrous septa or bands of more compact cellular area. The tumor cells were diffusely positive for S-100 and focally positive for Schwann/2E, which reacts with Schwann cells and myelin in the peripheral nervous system. The  positive reaction to Schwann/2E confirmed the occurrence of peripheral nerve sheath differentiation. Nerve sheath myxoma should be included in differential diagnosis of spinal canal tumors.

 

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[367]

TÍTULO / TITLE:  - Systematic Chemotherapy for Inoperable, Locally Advanced, Recurrent, or Metastatic Uterine Leiomyosarcoma: A Systematic Review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Oncol (R Coll Radiol). 2013 Jan 5. pii: S0936-6555(12)00362-7. doi: 10.1016/j.clon.2012.11.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clon.2012.11.008

AUTORES / AUTHORS:  - Gupta AA; Yao X; Verma S; Mackay H; Hopkins L

INSTITUCIÓN / INSTITUTION:  - Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Medical Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada.

RESUMEN / SUMMARY:  - The goal of this systematic review was to investigate and compare the treatment effects of systemic chemotherapy (i.e. doxorubicin, gemcitabine, gemcitabine plus docetaxel, or trabectedin) in women with inoperable, locally advanced, recurrent, or metastatic uterine leiomyosarcoma. A 2005 systematic review (searching the literature from 1980 to June 2004) on systemic therapy in advanced uterine sarcoma was used as the basis for this updated review. MEDLINE and EMBASE (from January 2004 to June 2011), the Cochrane Library, some main guideline websites and the American Society of Clinical Oncology and the Connective Tissue Oncology  Society annual meeting abstracts were searched. One arm from a randomised controlled trial (RCT), four single-arm phase II trials and one abstract were included in this systematic review. The studies of gemcitabine plus docetaxel have reported numerically longer median overall survival (14.7-17.9 months versus 12.1 months) and numerically higher objective response rates (27-53% versus 25%)  than those reported in the study of doxorubicin alone. The combination of gemcitabine plus docetaxel resulted in more toxicity than doxorubicin alone. The  available study for single-agent gemcitabine reported a tumour response rate of 21%, which is not superior to the 25% response rate with doxorubicin alone. One abstract (pooling data from two RCTs) failed to show the superiority of gemcitabine plus docetaxel over gemcitabine alone for tumour response rate (23% versus 18%) and progression-free survival (6 versus 4.9 months). To date, there is insufficient evidence to support or refute the use of trabectedin in the target patients. Doxorubicin, gemcitabine, and gemcitabine plus docetaxel are treatment options in women with inoperable, locally advanced, recurrent, or metastatic uterine leiomyosarcoma as first- or second-line therapy. Well-designed and good-quality RCTs are required to investigate the efficacy of chemotherapy and quality of life in target patients with uterine leiomyosarcoma.

 

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[368]

TÍTULO / TITLE:  - (18)F-FDG PET SUVmax as an indicator of histopathologic response after neoadjuvant chemotherapy in extremity osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur J Nucl Med Mol Imaging. 2013 Jan 30.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00259-013-2344-8

AUTORES / AUTHORS:  - Kong CB; Byun BH; Lim I; Choi CW; Lim SM; Song WS; Cho WH; Jeon DG; Koh JS; Yoo JY; Lee SY

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, South Korea.

RESUMEN / SUMMARY:  - PURPOSE: This study evaluated the usefulness of the maximum standardized uptake value (SUVmax) as a measure of histologic response to neoadjuvant chemotherapy in patients with extremity osteosarcoma. The correlation between [(18) F]FDG PET SUVmax values and histologic response to preoperative chemotherapy was also assessed prospectively using PET/MRI. METHODS: A total of 26 consecutive patients with high-grade osteosarcoma were prospectively enrolled. All patients underwent  parallel PET and MRI scans before and after neoadjuvant chemotherapy. Using the PET and MRI images and pathologic mapping, we assessed the percentage necrosis by histology at the highest metabolic activity point in the tumors. This was defined as the minimum histologic response. The predictive values of SUVmax before (SUV1) and after (SUV2) chemotherapy and the SUV change ratio were determined. Correlations were also investigated among SUV2, minimum histologic response and histologic response. RESULTS: Histologically, 13 patients were classified as good responders and 13 as poor responders. Patients with an SUV2 of >5 showed a poor histologic response. A significant correlation was found between SUV2 and histologic response (Spearman’s rho -0.642; P < 0.001), and SUV2 and histologic response were both found to be significantly correlated with minimum histologic response (Spearman’s rho -0.515 and 0.911; P = 0.007 and P < 0.001, respectively). CONCLUSION: A SUVmax of more than 5 after neoadjuvant chemotherapy identified the majority of histologic nonresponders (sensitivity 61.3 %, PPV 88.9 %). Tumor necrosis at the point of maximum metabolic activity was found to be significantly correlated with the histologic response of entire resected specimen.

 

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[369]

TÍTULO / TITLE:  - Breast Preservation in Women With Giant Juvenile Fibroadenoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Breast Cancer. 2012 Dec 13. pii: S1526-8209(12)00263-7. doi: 10.1016/j.clbc.2012.10.003.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.clbc.2012.10.003

AUTORES / AUTHORS:  - Matz D; Kerivan L; Reintgen M; Akman K; Lozicki A; Causey T; Clynes C; Giuliano R; Acs G; Cox J; Cox C; Reintgen D

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, University of South Florida, Tampa, FL; The Surgical Institute, Florida Hospital North Pinellas, the Breast Center, Florida Hospital,  Tampa, FL.

 

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[370]

TÍTULO / TITLE:  - Comparison of the Long-Term Risk of Recurrence and Other Clinical Outcomes in GIST Patients Receiving Imatinib as Adjuvant Therapy-A Retrospective Chart Extract-Based Approach.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Cancer. 2012 Dec 11.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12029-012-9467-1

AUTORES / AUTHORS:  - Conley AP; Guerin A; Sasane M; Gauthier G; Schwiep F; Keir CH; Wu EQ

INSTITUCIÓN / INSTITUTION:  - Department of Sarcoma, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA.

RESUMEN / SUMMARY:  - PURPOSE: To compare characteristics of patients, the risk of recurrence, and mortality among adult patients with primary resectable gastrointestinal stromal tumor (GIST) receiving short-term (6-12 months) versus long-term (>/= 24 months)  imatinib therapy. METHODS: Detailed information on primary resectable KIT-positive GIST patients initiated on imatinib adjuvant therapy was retrospectively collected for short- and long-term imatinib patients from 318 US  oncologists using an online data collection form. Patient characteristics were compared using Wilcoxon and Chi-square tests. Disease recurrence and mortality rates were compared using multivariate Cox proportional hazard models. RESULTS: Among the 406 short-term and 406 long-term imatinib patients, the median follow-up was 916 and 970 days, respectively. While patients generally had similar demographic characteristics, the short-term group had a higher prevalence of cardiovascular and ischemic heart diseases and patients in the long-term group had a higher pre-surgery risk profile. This finding was consistent with the main  reason reported by oncologists for prescribing adjuvant imatinib over longer duration, i.e., patient risk profile. Disease recurrence [5.9 versus 1.2 %, (p <  .001)] and mortality rates [7.1 % versus 2.0 %, (p < .001)] were higher in short- versus long-term patients. The adjusted risk of recurrence was 5.30 times (p < .001) higher, and mortality risk was 4.02 times (p < .001) higher in short- versus long-term patients. CONCLUSIONS: Patient risk profile is an important factor in oncologists’ decisions to prescribe adjuvant imatinib. Despite the higher risk profile observed in long-term patients, the long-term use of imatinib was associated with a reduction in long-term risk of disease recurrence and mortality.

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[371]

TÍTULO / TITLE:  - 18F-FDG PET/CT imaging of multiple myxofibrosarcoma in left upper abdomen and chest wall.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nuklearmedizin. 2012 Dec 17;51(6):N53-4.

AUTORES / AUTHORS:  - Yi C; Wang X; Shi X; Zhang X; Chen Z

 

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[372]

TÍTULO / TITLE:  - Atypical fibroxanthoma-a diagnosis of exclusion!

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Wien Med Wochenschr. 2013 Jan 15.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10354-012-0173-1

AUTORES / AUTHORS:  - Tchernev G; Tronnier M; Ananiev J; Taneva T; Patterson JW; Gulubova M; Trafeli JP; Gegova A; Harrell M; Guarneri C; Wollina U; Cardoso JC; Kanazawa N; Zisova L; Forsea AM; Zouboulis CC

INSTITUCIÓN / INSTITUTION:  - Polyclinic for Dermatology and Venereology, Medical Faculty, University Hospital  Lozenetz, Sofia University “St. Kliment Ohridski” University, Koziak Street 1, 1407, Sofia, Bulgaria, georgi_tchernev@yahoo.de.

RESUMEN / SUMMARY:  - Fibrohistiocytic tumors of the skin comprise a large range of lesions. One such tumor is the atypical fibroxanthoma (AFX), which is widely considered as a “pseudomalignant” tumor. It is derived from fibroblasts and expresses a variety of histiocytic markers. We present a case of AFX, localized in the right temporal region of the scalp, successfully treated with surgical excision. Immunohistochemical staining helps differentiate this tumor from others in the clinical differential diagnosis, including malignant melanoma, squamous cell carcinoma, and other nonmelanocytic spindle cell tumors such as leiomyosarcoma, rhabdomyosarcoma, angiosarcoma, liposarcoma, and dermatofibrosarcoma protuberans. Historically, AFX was believed to be a superficial variant of malignant fibrous histiocytoma (MFH). However, MFH is now considered a more generalized term for a  sarcomatous neoplasm of the subcutaneous tissue. The histopathology of MFH shares features with some malignant mesenchymal neoplasms such as liposarcoma, leiomyosarcoma, rhabdomyosarcoma, and angiosarcoma, but can be differentiated using immunohistochemistry and/or electron microscopy. More recently, the examples of MFH that do not exhibit a more specific line of differentiation have  been reclassified as undifferentiated pleomorphic sarcoma (UPS). Many authors currently cannot draw a distinction between AFX and UPS. The clinical and histopathological differences between AFX and UPS are often difficult to delineate. It is probable that they represent two poles of the same disease. Surgical excision in the patient we describe resulted in excellent aesthetic results with lack of recurrence in the 7-month postoperative period.

 

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[373]

TÍTULO / TITLE:  - Vascular leiomyoma in the oral cavity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gen Dent. 2013 Jan;61(1):e9-e11.

AUTORES / AUTHORS:  - Ghizoni JS; Baroni EM; Baroni EJ; de Oliveira MT; de Assistaveira LA

RESUMEN / SUMMARY:  - The aim of this study was to examine a case report of vascular leiomyoma located  in the oral mucosa of the oral cavity. Vascular leiomyoma is a benign tumor arising from smooth muscle. One factor that makes vascular leiomyomas in the oral cavity rare is that there is little smooth muscle in the mouth. The most common histological subtype in the oral cavity is the vascular subtype. The greatest difficulty in histological diagnosis of this entity is the similarity in morphology with other malignancies, particularly of neural or fibroblastic lineage. Wide surgical resection is the only treatment reported in the literature with good results. The recurrence rate is very low if complete resection is achieved. The study of rare or unusual lesions is very important for the clinical diagnosis of vascular leiomyoma.

 

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[374]

TÍTULO / TITLE:  - Pathological fracture as the presenting feature in pediatric osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2012 Dec 31. doi: 10.1002/pbc.24447.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24447

AUTORES / AUTHORS:  - Lee RK; Chu WC; Leung JH; Cheng FW; Li CK

INSTITUCIÓN / INSTITUTION:  - Department of Imaging and Interventional Radiology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, Hong Kong. leekalok2909@yahoo.com.hk.

RESUMEN / SUMMARY:  - BACKGROUND: Pathological fracture is an uncommon presentation in patients with long bone osteosarcoma. PROCEDURES: We retrospectively reviewed the database of all patients with histologically proven osteosarcoma under the age of 18 years from 1991 to 2011 in a tertiary pediatric oncology referral center. Five patients with pathological fractures as the first presentation of osteosarcoma were identified. The treatment strategies and complications were evaluated. Ten sex-,  age-, and site- matched osteosarcoma patients without pathological fracture were  selected as controls. The incidence of distant metastases and outcome, including  local recurrence and survival, were compared between the index (with pathological fracture) and the control (without pathological fracture) groups. RESULTS: In the index group, all five patients were boys and the mean age of onset was 13.1 years (range 9.2-14.9). Three patients (60%, 3/5) received amputation and two (40%) had wide local excision of the tumor. Pathological fracture group showed higher rate  of lung (60% vs. 10%, P = 0.04) and bone (60% vs. 10%, P = 0.04) metastases at presentation, and shorter overall 5-year survival (P = 0.04) than the control group. There was no significant difference of local recurrence (20%, P = 1.00) between these two groups regardless of the type of operation. CONCLUSION: Osteosarcoma complicated by pathological fracture as first presentation had higher incidence of lung and bone metastases at presentation and worse survival rate when compared with patients without pathological fracture. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc.

 

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[375]

TÍTULO / TITLE:  - Osteoblastoma of cervical spine causing an unusual neck pain.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Rev Med Pharmacol Sci. 2012 Oct;16 Suppl 4:17-20.

AUTORES / AUTHORS:  - Uccello M; Vacante M; Giordano M; Malaguarnera M; Biondi A; Basile F; Malaguarnera G; Pennisi M; Motta M

INSTITUCIÓN / INSTITUTION:  - School of Medicine, University of Catania, Catania, Italy.

RESUMEN / SUMMARY:  - Osteoblastoma is a rare benign tumor of bone that accounts for approximately 1% of primary skeletal neoplasms, with around 90% of cases diagnosed in the second and third decades of life. Cervical spine is an usual localization of osteoblastoma. The main clinical manifestation in case of cervical spine location is a progressive and resistant pain, possibly accompanied by stiffness, scoliosis or other ailments, including severe neurological deficits. Owing to a non-specific clinical presentation of osteoblastoma, the delay in diagnosis is common. Osteoblastomas may have an aggressive behavior, tend to enlarge and damage the bone and adjacent structures. The treatment of choice is, therefore, a wide and complete surgical excision of the lesion in order to achieve full recovery and prevent recurrence or, in some cases, malignant transformation. In the case of persistent neck pain, not readily relieved by aspirin and possibly accompanied by stiffness, scoliosis or neurological deficits, especially in young subjects, osteoblastoma of cervical spine may be one of the diagnostic options to be considered, in order to avoid delay in diagnosis. We report the case of a 41-year-old male affected by cervical spine osteoblastoma causing a lasting neck  pain.<br />

 

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[376]

TÍTULO / TITLE:  - Impact of extensive surgery in multidisciplinary approach of pterygopalatine/infratemporal fossa soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Blood Cancer. 2013 Jan 9. doi: 10.1002/pbc.24374.

            ●● Enlace al texto completo (gratuito o de pago) 1002/pbc.24374

AUTORES / AUTHORS:  - Minard-Colin V; Kolb F; Saint-Rose C; Fayard F; Janot F; Rey A; Canale S; Julieron M; Corradini N; Raquin MA; Habrand JL; Grill J; George B; Ba Huy PT; Couloignier V; Terrier-Lacombe MJ; Luboinski B; Valteau-Couanet D; Oberlin O

INSTITUCIÓN / INSTITUTION:  - Institut Gustave Roussy (IGR), Villejuif, France; Department of Pediatric and Adolescent Oncology, Villejuif, France. veronique.minard@igr.fr.

RESUMEN / SUMMARY:  - BACKGROUND: To evaluate a strategy whereby extensive surgery +/- external radiotherapy (RT) could improve local control in pterygopalatine/infratemporal fossa (PIF) sarcoma. PROCEDURE: Forty-one patients with a diagnosis of sarcoma involving the PIF and referred to our Institute from 1984 to 2009 were included in the analysis. Patients received multidrug chemotherapy and radiotherapy +/- surgery, depending on the period of treatment. RESULTS: The median age at diagnosis was 7.6 years (range: 0.1-22 years). There were 36 RMS, 3 undifferentiated sarcoma and 2 other soft-tissue sarcomas. Sixty-eight percent of patients had meningeal risk factors at diagnosis. Local treatment consisted of RT alone in 19 patients, surgery in combination to RT in 19 patients and surgery alone in 3 patients. The local progression rate (LPR) at 5 years was 45% for the  entire population, 59% for the 19 patients treated with RT alone and 34% for the  22 patients who had surgery as part of their treatment. All locoregional failures after extensive surgery occurred at the skull base and/or in leptomeningeal spaces. CONCLUSIONS: Multidisciplinary approach including extensive surgery for PIF sarcoma is feasible and yields good local control with 15/22 patients in local complete remission. Future studies are warranted to confirm these promising results, to evaluate the possibility of avoiding RT or limiting the RT field, and to extend the indication for extensive surgery to other “worse” sites of PM sarcoma such as the paranasal sinuses. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.

 

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[377]

TÍTULO / TITLE:  - Duodenal Gastrointestinal Stromal Tumors (GISTs): Arguments for Conservative Surgery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Surg. 2012 Nov 15.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11605-012-2075-3

AUTORES / AUTHORS:  - Bourgouin S; Hornez E; Guiramand J; Barbier L; Delpero JR; Le Treut YP; Moutardier V

INSTITUCIÓN / INSTITUTION:  - APHM Hopital Nord, Department of Visceral Surgery, Aix-Marseille University, Chemin des Bourrely, Marseille, France, stephane_bourgouin@hotmail.fr.

RESUMEN / SUMMARY:  - INTRODUCTION: Gastrointestinal stromal tumors (GISTs) of the duodenum are rare. We sought to evaluate the postoperative courses and long-term outcomes of conservative surgery (CS) versus pancreaticoduodenectomy (PD) for patients with non-metastatic duodenal GISTs. METHODS: Seventeen patients underwent surgery for  duodenal GISTs between January 2000 and January 2012; 11 patients underwent CS (CS group), and six patients underwent a PD (PD group). RESULTS: Mortality was similar between the two groups. Patients in the PD group had longer operative times, more tumors located on the pancreatic side of the duodenum, higher rates of post-operative complications including postoperative pancreatic fistulas, and  a longer hospital stay, when compared with patients of CS group. All tumors were  resected with clear surgical margins (R0 resection). The median disease-free survival times were not different. CONCLUSION: CS was safe and provided similar oncologic outcomes as PD. CS should be the procedure of choice in patients with GIST that does not involve the pancreatic side of the duodenum.

 

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[378]

TÍTULO / TITLE:  - Embryonal rhabdomyosarcoma of the female genital tract: 5 years’ experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Exp Ther Oncol. 2012;10(2):135-7.

AUTORES / AUTHORS:  - Hemida R; Goda H; Abdel-Hady el-S; El-Ashry R

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Mansoura University, Egypt. redaelshouky@hotmail.com

RESUMEN / SUMMARY:  - OBJECTIVES: To present our single institution experience with 10 cases of embryonal rhabdomyosarcoma diagnosed over 5 years. METHODS: Retrospective analysis of the medical records of 10 patients. The initial presenting data as age, complains and staging were analyzed. Surgical interference of all cases was  studied. The follow up data regarding survival and recurrences were analyzed. RESULTS: The mean age at diagnosis was 4.3 years (range: 2-12). Six cases (60%) were subjected to “True Cut” biopsy and 4 cases (40%) were subjected to complete  surgical excision of the tumor. All cases received chemotherapy. “Vincristine, Actinomycin D, Cyclophosphamide” combination was the most commonly used. Radiation therapy was used in 3 patients (30%) in the form of external beam radiation. The 5-year overall survival of our studied cases were 80%. CONCLUSION: The recurrence rate of our retrospectively studied 10 cases of embryonal rhabdomyosarcoma of vagina and cervix was high (70%). However, five-year survival was 80%. Combined modality treatment is essential to improve prognosis.

 

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[379]

TÍTULO / TITLE:  - Resection of a giant primary synovial sarcoma of the inferior vena cava extending into the right atrium with caval reconstruction under cardiopulmonary bypass and  circulatory arrest.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Perspect Vasc Surg Endovasc Ther. 2012 Jun;24(2):95-101. doi: 10.1177/1531003512468035.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1531003512468035

AUTORES / AUTHORS:  - Wise KB; Said SM; Clark CJ; Okuno SH; Shah SS; Park SJ; Nagorney DM; Gloviczki P

INSTITUCIÓN / INSTITUTION:  - 1Mayo Clinic, Rochester, MN, USA.

RESUMEN / SUMMARY:  - Background. Synovial sarcoma primarily arises in para-articular locations of the  extremities. However, numerous unique sites of origin have been reported. There are only 5 known cases of primary intravascular synovial sarcoma. Methods. We present the second reported case of synovial sarcoma arising from the inferior vena cava (IVC) in a 41-year-old woman with progressive fatigue, abdominal distension, and lower-extremity swelling. This is the first known case with a monophasic histological subtype. Results. The tumor arose from the retrohepatic IVC with cephalad extension into the right atrium. Excision required cardiopulmonary bypass and deep hypothermic circulatory arrest, followed by bovine pericardial patch reconstruction of the IVC. Conclusions. Primary synovial sarcoma of the IVC is rare. The use of cardiopulmonary bypass with or without deep hypothermic circulatory arrest may be required if there is tumor extension into the heart. Bovine pericardium is an excellent material for caval reconstruction.

 

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[380]

TÍTULO / TITLE:  - Characterization of Ewing sarcoma associated cancer/testis antigens.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Biol Ther. 2013 Jan 4;14(3).

AUTORES / AUTHORS:  - Mahlendorf DE; Staege MS

RESUMEN / SUMMARY:  - The prognosis of patients suffering from tumors of the Ewing family (EFT) is still poor. Immunotherapy strategies are pursued and EFT-specific antigens have to be identified as targets for cytotoxic T-lymphocytes (CTL). Due to the lack of expression of cancer/testis antigens (CTA) in normal tissues, these antigens are  partially able to induce immune responses in cancer patients. Therefore, they are promising targets for immunotherapy. EFT are characterized by chromosomal rearrangements involving members of the TET (translocated in liposarcoma, Ewing sarcoma breakpoint region 1, TATA box binding protein-associated factor 15) family of RNA binding proteins and members of the E-twenty-six (ETS) family of transcription factors. The resulting onco-fusion proteins are highly specific for EFT and downstream targets of TET-ETS represent candidate tumor specific antigens. In order to identify new EFT-associated CTA, we analyzed microarray-datasets from EFT and normal tissues from the Gene Expression Omnibus  (GEO) database. The impact of TET-ETS on expression of CTA was analyzed using GEO datasets from transgenic mesenchymal stem cells. One CTA with high specificity for EFT is lipase I (LIPI, membrane-associated phospholipase A1-beta). CTL specific for LIPI-derived peptides LDYTDAKFV and NLLKHGASL were able to lyse HLA-A2 positive EFT cells in vitro which confirms the possible role of LIPI and other CTA for EFT-immunotherapy.

 

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[381]

TÍTULO / TITLE:  - Endoscopic resection of a cardia gastrointestinal stromal tumour (GIST) after echoendoscopy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Gastroenterol Latinoam. 2012 Sep;42(3):230-3.

AUTORES / AUTHORS:  - de Lima DC; Alberti LR

INSTITUCIÓN / INSTITUTION:  - Biogastro Clinic and Federal University of Minas Gerais, Brazil. david@biogastro.com.br

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumours (GISTs) previously were thought to represent smooth muscle tumours of the gastrointestinal tract and were formerly classified  as leiomyomas and leiomyosarcomas. GISTs are the most common mesenchymal tumours  of the gastrointestinal tract and are of clinical relevance because in at least 10% to 30% of cases they are malignant. In the past, GISTs chemo and radio-resistance made treatment a challenging issue for physicians, while criteria for evaluation of the malignant potential of GISTs were lacking. Currently, identification of reliable prognostic factors and the development of molecular-targeted anticancer strategies for GIST have given new hope to these patients. The objective of the present work was to report a case of endoscopic resection of a cardia GIST.

 

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[382]

TÍTULO / TITLE:  - Left ventricular lipoma: a three-dimensional transesophageal echocardiographic appearance.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Card Surg. 2013 Jan;28(1):53. doi: 10.1111/jocs.12049. Epub 2012 Dec 4.

            ●● Enlace al texto completo (gratuito o de pago) 1111/jocs.12049

AUTORES / AUTHORS:  - Kelpis TG; Theofilogiannakos EK; Ninios VN; Pitsis AA

INSTITUCIÓN / INSTITUTION:  - St. Luke’s Hospital, Thessaloniki, Greece.

 

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[383]

TÍTULO / TITLE:  - Expansion of the maxilla. Craniofacial fibrous dysplasia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gen Dent. 2012 Sep-Oct;60(5):436, 437.

AUTORES / AUTHORS:  - Damm DD

INSTITUCIÓN / INSTITUTION:  - Department of Oral Health Sciences, Division of Oral Pathology, College of Dentistry, University of Kentucky, Lexington, USA.

 

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[384]

TÍTULO / TITLE:  - 50 Years Ago in CORR(®): Synovial Sarcoma Kirk J. Anderson, MD and Orliss Wildermuth, MD CORR 1961;29:55-70.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Orthop Relat Res. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11999-013-2792-2

AUTORES / AUTHORS:  - Brand RA

INSTITUCIÓN / INSTITUTION:  - Clinical Orthopaedics and Related Research, Philadelphia, PA, USA, eic@clinorthop.org.

 

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[385]

TÍTULO / TITLE:  - Angiofibroma of the nasal septum.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Middle East J Anesthesiol. 2012 Feb;21(4):653-5.

AUTORES / AUTHORS:  - Hamdan AL; Moukarbel RV; Kattan M; Natout M

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology—Head & Neck Surgery, American University of Beirut  Medical Center. alhamdan@scvlb.com

RESUMEN / SUMMARY:  - Angiofibromas originate predominantly in the nasopharynx. Extranasopharyngeal sites such as the paranasal sinuses and nasal cavity are less frequent. Angiofibroma of the nasal septum is extremely rare and the site of origin is either anterior, at the bony cartilaginous junction or posterior. Clinically, patients present with recurrent epistaxis and nasal obstruction secondary to a fleshy or polypoidal nasal mass. Computerized tomography of the nasal cavity and  bilateral carotid angiography are useful in the pre-operative work-up. The main stay of treatment is surgical resection. A rare case of nasal septal angiofibroma is hereby presented.

 

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[386]

TÍTULO / TITLE:  - A look at the College’s first registry: The Bone Sarcoma Registry.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bull Am Coll Surg. 2012 Dec;97(12):32-7.

 

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[387]

TÍTULO / TITLE:  - Completely infarcted smooth muscle tumor of the placental membrane.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Obstet Gynaecol Res. 2012 Dec 21. doi: 10.1111/j.1447-0756.2012.02043.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1447-0756.2012.02043.x

AUTORES / AUTHORS:  - Haltas H; Bayrak R; Yenidunya S; Tevrizci H

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, School of Medicine, Fatih University, Ankara, Turkey.

RESUMEN / SUMMARY:  - Non-trophoblastic tumor of the placenta is rare, and so is placental smooth muscle tumor. We report leiomyoma of the placental membrane, which was discovered on cesarean section. Histologically, the tumor was a benign leiomyoma with complete necrosis, and this finding was confirmed immunohistochemically. Only six cases of smooth muscle tumors of the placenta have been reported to date. This is the third report of leiomyoma involving the placental membrane.

 

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[388]

TÍTULO / TITLE:  - Upper airway study should always come before any sleep study in OSAS evaluation:  a giant parapharyngeal lipoma behind OSAS.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Rev Med Pharmacol Sci. 2012 Oct;16 Suppl 4:106-9.

AUTORES / AUTHORS:  - Casale M; Salvinelli F; Mallio CA; Frari V; Vincenzi B; Bressi F; Quattrocchi CC

INSTITUCIÓN / INSTITUTION:  - Campus Bio-Medico University, School of Medicine, Rome, Italy. m.casale@unicampus.it

RESUMEN / SUMMARY:  - BACKGROUND: The parapharyngeal space (PPS) is a rare site for neoplasms in the head and neck and lipoma represents 0.5% of all head and neck tumors. CASE REPORT: We describe a case of a giant parapharyngeal lipoma in obese adult patient causing anatomic pharyngeal obstruction with severe obstructive sleep apnea (OSA) syndrome. The patient was successfully operated with transcervical approach. CONCLUSIONS: In patients presenting with symptoms suggestive of OSA, it is essential to rule out any physical cause and perform a comprehensive ear, nose and throat examination including fibro-endoscopic upper airway examination before referral for sleep study and management. The ideal management for OSA involves treating the underlying cause. If no definitive cause is identified, management should begin with conservative measures such as lifestyle changes and a weight loss program; if these are unsuccessful, continuous positive airway pressure (CPAP), oral appliances or upper airway surgery could be considered. Better diagnostic methods should be developed to identify the main OSA causes and improve therapeutic outcomes.

 

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[389]

TÍTULO / TITLE:  - Biphasic solitary fibrous tumor of the orbit with distant metastases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int Ophthalmol. 2013 Jan 18.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10792-012-9706-2

AUTORES / AUTHORS:  - Parrozzani R; Fusetti S; Montesco C; Favero V; Midena E

INSTITUCIÓN / INSTITUTION:  - G.B. Bietti Eye Foundation, IRCCS, Via Livenza 3, 00198, Rome, Italy.

RESUMEN / SUMMARY:  - The aim of this study is to report the first case of biphasic solitary fibrous tumor (SFT) of the orbit with documented histological transformation and metastatic diffusion. We describe a case of a 23-year-old Caucasian man with recurrent SFT of the right orbit with intracranial invasion. The patient underwent surgical tumor removal via a right fronto-orbital approach. Histopathological examination showed a biphasic tumor pattern with both spindle cell and epithelioid components. The histopathological re-evaluation of previously removed lesions (1999 and 2004) confirmed the diagnosis of SFT, without any evidence of epithelioid component at that time. The patient developed local recurrence and systemic metastases (occipital foramen and clivus, paravertebral muscles and peritoneum) three years after surgery. We are unaware of previous reports of biphasic solitary fibrous tumor of the orbit with documented histological transformation and metastatic diffusion.

 

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[390]

TÍTULO / TITLE:  - Fibrous Dysplasia of Bone Associated with Primary Hyperparathyroidism.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Endocr Pract. 2013 Jan 21:1-16.

            ●● Enlace al texto completo (gratuito o de pago) 4158/EP12301.OR

AUTORES / AUTHORS:  - Turcu AF; Clarke BL

INSTITUCIÓN / INSTITUTION:  - Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, College of Medicine, Mayo Clinic, Rochester, MN.

RESUMEN / SUMMARY:  - Objective: Fibrous dysplasia of bone and primary hyperparathyroidism may each occur with the McCune-Albright Syndrome. A small number of cases with both diagnoses, but not associated with the above mentioned genetic disorder, have been published in the literature. It is uncertain if these disorders are linked in some way. In the present study, we aimed to further explore a potential relationship between primary hyperparathyroidism and fibrous dysplasia of bone.Methods: Retrospective review of all cases seen at Mayo Clinic, Rochester, Minnesota, between 1976 and 2011 that were diagnosed with both primary hyperparathyroidism and fibrous dysplasia of bone was conducted.Results: We identified 10 patients that were diagnosed with both primary hyperparathyroidism  and fibrous dysplasia of bone. Fibrous dysplasia was polyostotic in 7 (70%) cases. It affected the lower extremities in 6 (60%) patients, the skull or facial bones in 4 (40%) and was localized to one rib in one patient (10%). In 4 patients, fibrous dysplasia was diagnosed first, between 9 to 50 years before being diagnosed with primary hyperparathyroidism. Two cases of fibrous dysplasia  were recognized between 2 and 5 years after the diagnosis of primary hyperparathyroidism. The remaining 4 patients had both diagnoses made approximately simultaneously.Conclusion: It remains unclear if the association between fibrous dysplasia of bone and primary hyperparathyroidism is more than coincidental, although the possibility of a rare familial genetic syndrome is not completely excluded.

 

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[391]

TÍTULO / TITLE:  - Duplication of spine with hemi-lipomyelomeningocele.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Spine J. 2013 Jan 10.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00586-013-2655-2

AUTORES / AUTHORS:  - Yigit H; Ozdemir HM; Yurduseven E

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Ankara Training and Research Hospital, Sukriye Mah. Ulucanlar Cad., TR-06340, Altindag, Ankara, Turkey, hayigit@hotmail.com.

RESUMEN / SUMMARY:  - BACKGROUND: Duplication of the spine is very rare, and this malformation is generally considered as a severe form of type I split cord malformations. To the  best of our knowledge, this is the first reported case of spine duplication associated with lipomyelomeningocele. CASE: We report an exceptional case of 14-year-old, asymptomatic and neurologically intact girl with duplication of the  spine and marked separation of bony elements at thoraco-lumbar region. One of the split thecal sacs includes a tethered spinal cord whereas other thecal sac has no visible neural content, and there is a neighbor lipomyelomeningocele located in the midline. CONCLUSION: A surgical operation was planned to release the tethered cord and instrumentation and fusion for scoliosis; however, the operation was declined by the patient.

 

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[392]

TÍTULO / TITLE:  - Pulmonary metastasectomy for sarcoma of gynaecologic origin.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Heart Lung Circ. 2012 Dec 20. pii: S1443-9506(12)01369-8. doi: 10.1016/j.hlc.2012.11.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.hlc.2012.11.001

AUTORES / AUTHORS:  - Paramanathan A; Wright G

INSTITUCIÓN / INSTITUTION:  - University of Melbourne, Australia.

RESUMEN / SUMMARY:  - INTRODUCTION: Pulmonary metastases are relatively common after definitive treatment for sarcoma of soft tissue and bone. Minimal data exists on outcomes following pulmonary metastasectomy for sarcoma of gynaecologic origin (SOGO). A retrospective study was performed to compare overall outcomes of pulmonary metastasectomy for SOGO. METHODS: Patients selected had control of their primary  tumour, no extra-thoracic disease and were declared fit for surgery. The primary  aim was to determine long-term outcomes following pulmonary metastasectomies in patients with sarcoma of gynaecological origin. The International Registry of Lung Metastases (IRLM) staging system, resection status and surgical approach were documented. RESULTS: Of 101 patients who underwent sarcoma pulmonary metastasectomy between the 2001 and 2011, 13 patients had SOGO (12 leiomyosarcoma). The median age for those undergoing resection for SOGO was 58.2  years. Four patients required iterative metastasectomy. Median OS for SOGO was 76.4 months (95% CI: 11.8-141.0). The three- and five-year survival for sarcoma of gynaecologic origin was 76% and 66% respectively. For all sarcoma cases, minimally invasive surgery was shown to confer a significant survival benefit; five-year OS was 67% compared to 38% for open surgery (p=0.04). DISCUSSION: Outcomes after pulmonary metastasectomy for SOGO are favourable compared to other sarcoma resection. IRLM staging was a good predictor of patient outcome. Minimally invasive surgery may have oncologically equivalent outcomes compared to open surgery.

 

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[393]

TÍTULO / TITLE:  - Obstructive Right Atrial Myxoma in Association with Carney Complex.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Heart Lung Circ. 2012 Dec 21. pii: S1443-9506(12)01372-8. doi: 10.1016/j.hlc.2012.10.015.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.hlc.2012.10.015

AUTORES / AUTHORS:  - Wang LW; Granger EK

INSTITUCIÓN / INSTITUTION:  - Department of Cardiology, St Vincent’s Hospital and the University of New South Wales, Sydney, Australia; University of New South Wales, Australia. Electronic address: louis.wang@unsw.edu.au.

 

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[394]

TÍTULO / TITLE:  - Synovial sarcomas of the head and neck: Comparative analysis with synovial sarcoma of the extremities.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Auris Nasus Larynx. 2012 Dec 20. pii: S0385-8146(12)00239-8. doi: 10.1016/j.anl.2012.11.015.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.anl.2012.11.015

AUTORES / AUTHORS:  - Salcedo-Hernandez RA; Lino-Silva LS; Luna-Ortiz K

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Oncology, Instituto Nacional de Cancerologia, Mexico, D.F., Mexico.

RESUMEN / SUMMARY:  - OBJECTIVE: This study analyzed synovial sarcoma (SS) of the head and neck in order to identify features associated with survival improvement and compared them with the survival of SS of limbs. METHODS: Clinical charts and histopathologic material with analysis for SYT/SSX gene rearrangement of 16 patients were reviewed. The clinicopathologic features and their association with survival were analyzed and compared with 174 SS of limbs. RESULTS: The average age was 24.2 years (range 21-86). Eight cases occurred in each sex. The most frequent site was the parapharyngeal space (PPS). The mean tumor size was 5.38cm. Sixty-nine percent occurred in Stages II-III and 9% in Stage IV. Fifteen cases were excised: R0 resection in seven (46.7%) cases and R1 resection in eight (53.3%) cases. No patient with R0 resection has recurred, and three patients (37.5%) with R1 resection have recurred (p=0.035). Patients with R0 surgery had better survival rates compared to those who received other treatments (p=0.045). SS of head and neck showed a 5-year survival rate of 58% compared to 44.6% of the limbs (p=0.450). CONCLUSION: The most prevalent location was the PPS. Surgical resection with clear margins correlated with low recurrence. Head and neck sarcomas had similar survival rates compared to sarcomas of limbs.

 

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[395]

TÍTULO / TITLE:  - Optimized culture conditions for tissue explants of uterine leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Lab. 2012;58(11-12):1153-64.

AUTORES / AUTHORS:  - Fiebitz A; Fritsch M; Reichelt U; Ruester C; Chiantera V; Vercellino GF; Darwish A; Schneider A; Mechsner S

INSTITUCIÓN / INSTITUTION:  - Department of Gynaecology, Charite Hospital Campus Benjamin Franklin, Berlin, Germany.

RESUMEN / SUMMARY:  - BACKGROUND: Uterine leiomyomas are the most common benign tumours in women, which arise from smooth muscle cells of the uterine myometrium and usually are multicentric. In spite of their frequency pathogenesis is widely unknown, mainly  due to the absence of a suitable model system. We describe the systematic optimization of culturing leiomyoma tissue explants in an economical and effective ex vivo system. METHODS: Different concentrations of oxygen, different  media, sera, hormones, and growth factor supplements were tested. Immunohistochemical stainings with antibodies against hormone receptors as well as specifying proliferation and apoptotic indices and real-time PCR were performed. RESULTS: Main parameters for culturing myoma tissue explants were tested for finding an optimal protocol. Standard medium D-MEM-F12 in combination  with the use of horse serum in a reduced concentration of 1% turned out to be optimal for these tissue cultures as well as the addition of estradiol and epidermal growth factor EGF to media. Reduced oxygen content in the incubator air showed no positive effect. CONCLUSIONS: For culturing tissue explants of uterine  leiomyoma several conditions were optimized. The established tissue culture model allows examining the effects of known and potential therapeutic substances and the influence of immune competent cells in the process of tumour formation to find new targets for medical treatment.

 

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[396]

TÍTULO / TITLE:  - The miRNAs in the pathgenesis of osteosarcoma .

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Front Biosci. 2013 Jan 1;18:788-94.

AUTORES / AUTHORS:  - Liang W; Gao B; Fu P; Xu S; Qian Y; Fu Q

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, Changhai Hospital of Second Military Medical University, Shanghai 200433, China.

RESUMEN / SUMMARY:  - Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. MicroRNAs  (miRNAs) are non-coding small RNAs, usually 18-25 nucleotides in length, which repress translation and cleave mRNA by base-pairing to the 3 untranslated region  of the target genes. miRNAs have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. A number of reports have investigated the role of microRNAs in osteosarcoma. This review summeizes the recent research progress of  miRNA in the osteosarcome.

 

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[397]

TÍTULO / TITLE:  - Concurrent fibroadenoma and intraductal papilloma - A recurring complex lesion in a premenarcheal girl.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Res Pract. 2012 Dec 4. pii: S0344-0338(12)00301-9. doi: 10.1016/j.prp.2012.10.011.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.prp.2012.10.011

AUTORES / AUTHORS:  - Alessandrini L; Gobbi D; Zanon GF; Dall’igna P; Cecchetto G; Alaggio R

INSTITUCIÓN / INSTITUTION:  - Department of Medicine - Pathology Section, University - Hospital of Padua, Padua, Italy.

RESUMEN / SUMMARY:  - Breast diseases are rare in childhood and adolescence, most lesions being fibroadenomas and papillomas. We report the case of an 11-year old girl with a complex breast lesion with hybrid features of fibroadenoma and intraductal papilloma with an early recurrence. Microscopically, the lesion was composed of dilated ducts showing intraluminal papillary projections with small to broad fibrovascular stalks. The typical leaf-like appearance of fibroadenoma was determined by the presence at the periphery of ducts compressed and distorted by  the prominent stromal component. Despite its florid epithelial hyperplasia and mild cytological atypia (more evident in the relapse), immunohistochemical staining for p63 and smooth muscle actin highlighted a continuum outer myoepithelial layer, confirming the non-invasive appearance of the lesion. Two pathogenetic links have been hypothesized: one is based on the morphological continuum between these two entities, which may represent different evolutive stages in the same lesion; the other is based on epithelial/mesenchymal interactions. The possible malignant transformation of such complex lesion is also discussed, along with its differential diagnoses. The relevance of this case lies in its rarity, as well as in the therapeutic strategies related to its biological potential and to the necessity of a conservative treatment, due to the young age of the patient.

 

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[398]

TÍTULO / TITLE:  - Intramuscular lipoma of the tongue masquerading as angioedema.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ear Nose Throat J. 2013 Jan;92(1):E4-5.

AUTORES / AUTHORS:  - Amirzadeh A; Klaustermeyer W

INSTITUCIÓN / INSTITUTION:  - Allergy and Immunology Group, Walla Walla Clinic, 55 W. Tietan St., Walla Walla,  WA 99362, USA. ali.amirzadeh@wallawallaclinic.com.

RESUMEN / SUMMARY:  - In most cases, the diagnostic evaluation of angioedema is challenging, as there are many possible etiologies. We report a case of an infiltrating lipoma of the tongue that masqueraded as angioedema. The patient, a 68-year-old man, presented  with tongue swelling that had followed a waxing and waning course over a 6-month  period. Physical examination showed a diffusely enlarged tongue with no discrete  mass. A laboratory evaluation for angioedema was unremarkable. After the patient’s condition did not respond to treatment with antihistamines and oral prednisone, a further workup was initiated. Magnetic resonance imaging of the neck and computed tomography of the oral cavity revealed only diffuse enlargement of the tongue. The patient underwent a tongue biopsy, which identified the cause  of the swelling to be an infiltrating lipoma of the tongue. Clinicians should be  aware that other causes of tongue swelling may mimic angioedema.

 

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[399]

TÍTULO / TITLE:  - Hip-sparing approach using computer navigation in periacetabular chondrosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Comput Aided Surg. 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 3109/10929088.2012.743587

AUTORES / AUTHORS:  - Gerbers JG; Jutte PC

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, University Medical Center Groningen , Groningen , The Netherlands.

RESUMEN / SUMMARY:  - Chondrosarcoma of the pelvis is difficult to treat due to the anatomical location and the high incidence of recurrence. Treatment is primarily surgical, and the surgical margins, based on MSTS criteria, have been shown to be predictive of disease recurrence and mortality. However, too-wide margins can decrease post-operative function. In the presented case, computer assisted surgery (CAS) was used to safely enable a joint-salvaging approach in a modified type 2/3 resection of a grade 2 chondrosarcoma of the os ischium and os pubis. The CAS navigation was vital to achieving the desired safe margins. The current follow-up period is 3.5 years, and the patient is disease-free, with no local recurrences or metastases having been detected. Post-operative function is excellent, with good MSTS and SF36 scores. This outcome is a good example of the value of CAS in  certain cases.

 

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[400]

TÍTULO / TITLE:  - Chondroid Tenosynovial Giant Cell Tumor of the Temporal Bone.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Otol Neurotol. 2013 Jan 7.

            ●● Enlace al texto completo (gratuito o de pago) 1097/MAO.0b013e31827d06f6

AUTORES / AUTHORS:  - Fisher M; Biddinger P; Folpe AL; McKinnon B

INSTITUCIÓN / INSTITUTION:  - *Department of Otolaryngology-Head and Neck Surgery, and daggerDepartment of Pathology, Georgia Health and Sciences University, Augusta, Georgia; and double daggerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, U.S.A.

 

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[401]

TÍTULO / TITLE:  - Lipoma of the pancreas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pancreatology. 2012 Nov-Dec;12(6):493-4.

AUTORES / AUTHORS:  - Maderuelo MM; Gonzalez Valverde FM; Marin-Blazquez AA

INSTITUCIÓN / INSTITUTION:  - Surgery Department, Hospital General Universitario Reina Sofia de Murcia, Avda. Intendente Jorge Palacios n degrees 1, 30003 Murcia, España.

 

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[402]

TÍTULO / TITLE:  - Using diffusion weighted MR imaging in a lipomatous chest wall lesion.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JBR-BTR. 2012 Sep-Oct;95(5):306-8.

AUTORES / AUTHORS:  - Incedayi M; Saglam M; Sonmez G; Sivrioglu AK; Tekin L

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. m_incedayi@yahoo.com

RESUMEN / SUMMARY:  - Hibemoma is a rare benign soft tissue tumor derived from brown fat.The tumor is also known as “fetal lipoma, lipoma of embryogenic fat and lipoma of immature adipose tissue. Hibemomas are slow-growing, painless soft tissue tumors which do  not recur after surgical resection. Preferred locations are brown fat containing  sites as thigh, interscapular region, shoulder, axilla, and mediastinum.The tumor occurs most commonly in adults, with a mean age of 38 years (age range, 2-75 years). We present a rare case of hibernoma with radiological and pathological findings.

 

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[403]

TÍTULO / TITLE:  - Prolonged Therapy with Imatinib Mesylate before Surgery for Advanced Gastrointestinal Stromal Tumor Results of a Phase II Trial.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Oncol. 2012;2012:761576. doi: 10.1155/2012/761576. Epub 2012 Dec 17.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/761576

AUTORES / AUTHORS:  - Doyon C; Sideris L; Leblanc G; Leclerc YE; Boudreau D; Dube P

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Maisonneuve-Rosemont Hospital, University of Montreal, Montreal, QC, Canada H1T 2M4.

RESUMEN / SUMMARY:  - Purpose. Proven efficacy of imatinib mesylate in gastrointestinal stromal tumour  (GIST) has led to its use in advanced disease and, more recently, in adjuvant and neoadjuvant settings. The purpose of this study was to evaluate the optimal neoadjuvant imatinib duration to reduce the morbidity of surgery and increase the possibility of resection completeness in advanced tumours. Patients and Method. Patients with advanced GIST were enrolled into a registered open-label multicenter trial and received imatinib daily for a maximum of 12 months, followed by en bloc resection. Data were prospectively collected regarding tumour assessment, response rate, surgical characteristics, recurrence, and survival. Results. Fourteen patients with advanced GIST were enrolled. According to RECIST  criteria, 6 patients had partial response and 8 had stable disease. The overall tumour size reduction was 25% (0-62.5%), and there was no tumour progression. Eleven patients underwent tumour resection, and all had R0 resection. After a median followup of 48 months, 4-year OS and DFS were 100% and 64%, respectively.  Conclusion. This prospective trial showed that one year of neoadjuvant imatinib in advanced GIST is safe and associated with high rate of complete microscopic resection. It is not associated with increased resistance, progression, or complication rates.

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[404]

TÍTULO / TITLE:  - Degeneration of leiomyoma in patients referred for uterine fibroid embolization:  incidence, imaging features and clinical characteristics.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Yonsei Med J. 2013 Jan 1;54(1):215-9. doi: 10.3349/ymj.2013.54.1.215.

            ●● Enlace al texto completo (gratuito o de pago) 3349/ymj.2013.54.1.215

AUTORES / AUTHORS:  - Han SC; Kim MD; Jung DC; Lee M; Lee MS; Park SI; Won JY; Lee do Y; Lee KH

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea.

RESUMEN / SUMMARY:  - PURPOSE: Imaging features and clinical characteristics of degenerated leiomyoma in patients referred for uterine fibroid embolization (UFE) were analyzed to assess the incidence of degenerated leiomyoma. MATERIALS AND METHODS: Patients referred for UFE between 2008 and 2009 were retrospectively analyzed (n=276). Patients ranged in age from 27 to 51 years (mean 38.0 years). All patients underwent screening MRI with contrast enhancement. Medical histories and clinical symptoms were evaluated. RESULTS: Among the 276 patients who underwent MRI, 14 (5.1%) showed degenerated leiomyomas. Symptoms were abdominal pain (n=4, 26.7%),  menorrhagia (n=5, 35.7%) and bulk-related symptoms (n=5, 35.7%) and no symptoms (n=5, 35.7%). Of the 14 patients with degenerated leiomyomas, 5 (42.9%) had a history of pregnancy in the past two years. For T1-weighted imaging (T1WI), a high signal intensity (SI) of the leiomyoma was the most common finding (n=9, 64.3%) and a hyperintense rim (n=4, 28.6%) was the second most common. On T2-weighted imaging (T2WI), a low SI of the leiomyoma was found in six patients (42.9%), a high SI in four (28.6%) and a heterogeneous SI in four (28.6%) patients. Conservative management was performed in 11 (78.6%) patients, surgery in 3 (21.4%) and uterine artery embolization in one (7.1%) patient. CONCLUSION: The incidence of degeneration of leiomyoma in patients referred for UFE was 5.1%. Patients presented with variable clinical symptoms with or without a history of pregnancy. MR imaging showed a high SI on T1WI and various SIs on T2WI without contrast enhancement. An understanding of the degeneration of leiomyomata is essential when considering UFE.

 

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[405]

TÍTULO / TITLE:  - Role of mammalian target of rapamycin inhibitor in the treatment of metastatic epithelioid angiomyolipoma: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Urol. 2013 Jan 24. doi: 10.1111/iju.12095.

            ●● Enlace al texto completo (gratuito o de pago) 1111/iju.12095

AUTORES / AUTHORS:  - Kohno J; Matsui Y; Yamasaki T; Shibasaki N; Kamba T; Yoshimura K; Sumiyoshi S; Mikami Y; Ogawa O

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Kyoto University Hospital, Kyoto, Japan.

RESUMEN / SUMMARY:  - Epithelioid angiomyolipoma has malignant potential; however, no effective therapy has been established for advanced cases. A 50-year-old woman with a history of right nephrectomy for epithelioid angiomyolipoma was referred to our institution. Computed tomography and magnetic resonance imaging showed multiple tumors in her  lung, liver and pelvic cavity. The liver and pelvic tumor specimens obtained by needle biopsy confirmed the diagnosis of epithelioid angiomyolipoma recurrence. The patient was treated with everolimus (10 mg/day). Three months later, pulmonary lesions disappeared; liver and pelvic tumors significantly shrank in size, but the pelvic tumor gradually enlarged again. We carried out surgical resection of the residual liver and pelvic cavity tumors. Although the mammalian  target of rapamycin inhibitor seems to be effective for treating epithelioid angiomyolipoma, its long-term effects remain unknown. Thus, aggressive administration of a multidisciplinary treatment including molecular target therapy and surgical resection is required to improve the prognosis of epithelioid angiomyolipoma.

 

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[406]

TÍTULO / TITLE:  - Magnetic resonance imaging findings in cardiac lipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JBR-BTR. 2012 Sep-Oct;95(5):300-1.

AUTORES / AUTHORS:  - Schiettecatte A; Verdries D; de Mey J; De Maeseneer M; Dujardin M

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, UZ Brussel, Brussels, Belgium. ann.schiettecatte@uzbrussel.be

RESUMEN / SUMMARY:  - Cardiac lipomas are exceedingly rare benign tumors of the heart. They are usually asymptomatic. Occasionally, they are found on MRI as an incidental finding. We report a case of a 68-year-old woman who presented with shortness of breath. Transoesophageal echocardiography depicted a cardiac mass lesion. The diagnosis of an intracardiac lipoma was confirmed by characterization of this mass with MRI imaging. No surgery was required since the lesion did not exert a hemodynamic effect.

 

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[407]

TÍTULO / TITLE:  - Treatment of advanced gastrointestinal stromal tumors in patients over 75 years old: clinical and pharmacological implications.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Target Oncol. 2012 Dec 21.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11523-012-0243-8

AUTORES / AUTHORS:  - Italiano A; Saada E; Cioffi A; Poulette S; Bouchet S; Molimard M; Adenis A; Isambert N; Collard O; Le Cesne A; Maki RG; Bui B

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Institut Bergonie, 229 Cours de l’Argonne, 33076, Bordeaux cedex, France, a.italiano@bordeaux.unicancer.fr.

RESUMEN / SUMMARY:  - Data about the patterns of care and the specific outcome of elderly patients with advanced gastrointestinal stromal tumors (GISTs) are almost nonexistent. Between  2001 and 2009, 44 patients >/=75 years old with advanced GISTs started first-line imatinib (400 mg/day) in seven participating institutions. Clinical data were collected by reviewing medical records and were entered in a comprehensive database. During the same period, 160 patients with advanced GIST (136 patients <75 years old, 24 patients >/=75 years old) had access to an imatinib blood level testing program. Imatinib plasma concentration (patient dose 400 mg/day) tests were centralized in a single laboratory. Median age was 78 years old (range 75-86). Thirty-six patients (82 %) experienced at least one adverse event (Table  2). Drug-related adverse events were mainly of grades 1 and 2 and were medically  manageable. Permanent dose reduction (200-300 mg/day) was required for 20 patients (45.5 %) and was significantly more frequent for patients with performance status (PS) >/=2: 33.5 versus 8.5 %, p = 0.04. Eight patients (18 %)  required imatinib interruption for intolerance. Median PFS was 34.4 months (95 %  CI 11.5-57.4) (Fig. 1). Median overall survival (OS) was 50.3 months (95 % CI 37-63.5). Performance status <2 was the sole pre-therapeutic factor associated with improved OS. No correlation was found between comorbidities and tolerance or outcome. Imatinib trough plasma concentrations increase with age, although this correlation did not reach statistical significance. First-line imatinib is a feasible and effective treatment in patients with advanced GISTs >/=75 years. Aging seems to have only a moderate impact on imatinib pharmacokinetics. Overall  survival is similar to that of younger patients. Comorbidities did not result in  increased incidence of toxicity. Careful follow-up regarding tolerance issues should be considered in elderly patients with poor PS.

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[408]

TÍTULO / TITLE:  - Photodynamic therapy combined with intravitreal bevacizumab in a patient with choroidal neovascularization secondary to choroidal osteoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Ophthalmol. 2012 Dec;26(6):478-80. doi: 10.3341/kjo.2012.26.6.478. Epub  2012 Nov 12.

            ●● Enlace al texto completo (gratuito o de pago) 3341/kjo.2012.26.6.478

AUTORES / AUTHORS:  - Jang JH; Kim KH; Lee SJ; Park JM

INSTITUCIÓN / INSTITUTION:  - Department of Ophthalmology, Maryknoll Medical Center, Busan, Korea.

RESUMEN / SUMMARY:  - Choroidal osteoma is a benign ossified tumor that is found predominantly in healthy young women during their second and third decades of life. The lesions are white-to-cream or orange in color, are located in the peripapillary and macular areas, and are unilateral in most patients. The symptoms of choroidal osteoma include decreased visual acuity and metamorphopsia or scotoma corresponding to the location of the osteoma, but some patients have no symptoms. Prognosis of vision varies according to tumor location, retinal pigment epithelial and sensory retinal degeneration, subretinal fluid and hemorrhage, and development of a subretinal neovascular membrane.

 

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[409]

TÍTULO / TITLE:  - Multiple gastrointestinal stromal tumors and pheochromocytoma in a patient with von Recklinghausen’s disease.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Case Rep. 2013;4(2):216-8. doi: 10.1016/j.ijscr.2012.10.024. Epub 2012 Nov 23.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2012.10.024

AUTORES / AUTHORS:  - Ozcinar B; Aksakal N; Agcaoglu O; Tukenmez M; Ozemir IA; Barbaros U; Colak N; Erbil Y

INSTITUCIÓN / INSTITUTION:  - Istanbul University, Istanbul Medical Faculty, General Surgery Department, Capa,  Istanbul, Turkey. Electronic address: drbeyza@hotmail.com.

RESUMEN / SUMMARY:  - INTRODUCTION: Neurofibromatosis type 1 is a genetic disease characterized by neoplastic and non neoplastic disorders involving tissues of neuroectodermal and  mesenchymal origin. Herein, we present a case with von Recklinghausen’s disease,  right adrenal heochromocytoma and multiple gastrointestinal stromal tumors. PRESENTATION OF CASE: A forty-eight year old male patient was admitted to our Emergency Department with melena. His physical examination revealed multiple neurofibromas all over the skin, kyphosis, multiple cafe au lait spots and Lisch  nodules on the eye and, melena on digital rectal examination. Abdominal computerized tomography scan showed a mass on right adrenal gland and multiple soft tissue mass lesions between distal part of pancreas and small bowel. Adrenal mass was determined as a pheochromocytoma and small bowel lesions were verified as stromal tumors. DISCUSSION: In patients with NF1, pheochromocytomas and GISTs  are well known neoplasms seen with increased incidence than the general population. CONCLUSION: In patients with NF1, any symptoms with other systems should be managed carefully for underlying malignity.

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[410]

TÍTULO / TITLE:  - A Case of Scalp Angiosarcoma with Lung Metastases Presenting as Multiple Thin-walled Cysts.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Jpn J Clin Oncol. 2013 Jan;43(1):101. doi: 10.1093/jjco/hys224.

            ●● Enlace al texto completo (gratuito o de pago) 1093/jjco/hys224

AUTORES / AUTHORS:  - Namikawa K; Yamazaki N

 

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[411]

TÍTULO / TITLE:  - Six-year survival of a patient with pulmonary artery angiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asian Cardiovasc Thorac Ann. 2012 Dec;20(6):728-30. doi: 10.1177/0218492312441780.

            ●● Enlace al texto completo (gratuito o de pago) 1177/0218492312441780

AUTORES / AUTHORS:  - Chaubey S; Benson C; Khan H; Monaghan M; Shah AM; Judson I; Wendler O

INSTITUCIÓN / INSTITUTION:  - hkhan76@hotmail.com.

RESUMEN / SUMMARY:  - Angiosarcomas of the pulmonary artery are rare and carry a very poor prognosis. We describe the case of a patient with pulmonary artery angiosarcoma who underwent radical resection followed by chemotherapy and was alive after 6 years  of follow-up. Our case demonstrates that a multidisciplinary approach including cardiac diagnostics, radical surgery, and effective adjuvant chemoradiotherapy can improve outcome.

 

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[412]

TÍTULO / TITLE:  - Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Orthop Surg Res. 2012 Dec 10;7:38. doi: 10.1186/1749-799X-7-38.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1749-799X-7-38

AUTORES / AUTHORS:  - Yokota K; Sakamoto A; Matsumoto Y; Matsuda S; Harimaya K; Oda Y; Iwamoto Y

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. akio@med.kyushu-u.ac.jp.

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: Dedifferentiated chondrosarcomas consist of two distinguishable components: low-grade chondrosarcoma components and high-grade dedifferentiated components. MATERIALS AND METHODS: Nine cases (4 males, 5 females) of dedifferentiated chondrosarcoma were treated in our institute. The average age was 58.6 (range, 37-86) years. The tumor location was the long bone in 7 cases (femur, n=5; humerus, n=1; tibia, n=1) and the pelvic bone in 2 cases. The average time from appearance of symptoms to treatment was 9.4 (range, 1-40) months. RESULTS AND DISCUSSION: On plain radiographs, matrix mineralization was seen in all 9 cases (100%). Bone destruction was observed in 5 of 9 cases (56%),  while pathological fracture was seen in one femur case (11%). Lung metastasis was observed in all cases (initially in 5 cases; during the treatment course in 4 cases). Surgery was performed in 8 cases, with local recurrence occurring in 2 of those cases (time to recurrence, 2 and 10 months). Chemotherapy was administered  in 4 cases, but did not result in significant improvement. All 9 cases died of lung metastases, with a median survival time of 10 (range, 3.4-18.8) months. The  presence of initial metastasis at diagnosis was a significant unfavorable prognostic factor. CONCLUSION: The prognosis of dedifferentiated chondrosarcoma is dismal. With the lack of convincing evidence of the benefit of chemotherapy, complete surgical excision is the initial recommended treatment.

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[413]

TÍTULO / TITLE:  - Nephron-sparing surgery for giant angiomyolipomas of kidney.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Ital Urol Androl. 2012 Sep;84(3):146-50.

AUTORES / AUTHORS:  - Siena G; Minervini A; Tuccio A; Vittori G; Salvi M; Sebastianelli A; Saleh O; Lapini A; Serni S; Carini M

INSTITUCIÓN / INSTITUTION:  - Department of Urology, University of Florence, Careggi Hospital, Florence, Italy. giampaolo.siena@gmail.com

RESUMEN / SUMMARY:  - AIMS: To investigate the potential role of tumor enucleation (TE) for the treatment of giant angiomyolipomas (AML). METHODS: We retrospectively analyzed a  prospectively derived database of 707 patients with kidney tumor, who were treated with conservative surgery, between January 1995 and September 2009. Overall, 31 patients had a histopathologic diagnosis of renal AML and of those, 3 patients had a diagnosis of unilateral or bilateral renal mass, with at least one clinically suggestive of giant AML (maximal tumor diameter > or = 9 cm), either central or perihilar. These patients were the subjects of the analysis. Nephron sparing surgery (NSS) was performed as tumor enucleation (TE), carried out by a blunt dissection, using the natural cleavage plane between the tumor and the normal parenchyma. RESULTS: Preoperative tumor size ranged between 9.0 and 15.0 centimetres. At surgery, after kidney capsule incision, TE was done in all cases. In critical surgical steps, in case of difficult visualization of the correct enucleation plane, a sharp dissection a few millimetres away from the tumor was adopted. Warm ischemia time (WIT) was always below 20 minutes. Intraoperative blood loss was negligible. Unsignificant postoperative creatinine variation was recorded in all cases. No intra- and post-operative complications occurred. At last follow up visit, no tumor recurrence at the enucleation site was reported. CONCLUSIONS: TE technique can be considered a viable and effective treatment option for this very rare pathologic condition, since it provides a maximal glomerular preservation and minimizes WIT and intra- and postoperative complications.

 

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[414]

TÍTULO / TITLE:  - A case of ovarian sclerosing stromal tumour concomitant with endometrial adenocarcinoma in a postmenopausal woman.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Obstet Gynaecol. 2013 Jan;33(1):97-8. doi: 10.3109/01443615.2012.717990.

            ●● Enlace al texto completo (gratuito o de pago) 3109/01443615.2012.717990

AUTORES / AUTHORS:  - Kutuk MS; Ozgun MT; Uludag S; Serin IS; Akgun H

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology.

 

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[415]

TÍTULO / TITLE:  - A case of angiomyolipoma of the spermatic cord and testicle.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Ital Urol Androl. 2012 Sep;84(3):165-6.

AUTORES / AUTHORS:  - Giulianelli R; Albanesi L; Attisani F; Brunori S; Gentile BC; Mavilla L; Mirabile G; Pisanti F; Vincenti G; Shestani T; Schettini M

INSTITUCIÓN / INSTITUTION:  - Villa Tiberia Clinic, Urology Department, Rome, Italy. roberto.giulianelli@virgilio.it

RESUMEN / SUMMARY:  - Angiomyolipomas (AML) are mesenchymal tumors of the kidney consisting of varying  proportions of vascular, immature smooth muscle and mature fat cells. A rare case of testicular AML is described. A 53 year old male with a history of congenital motor defects, mental retardation, and hypertension, presented to the emergency room with sudden onset, severe left testicular pain. Scrotal sonography demonstrated an hypoechoic mass in the patient’s left testicle. The patient was offered and underwent a trans-inguinal exploration of the left testicle which ended in a left inguinal orchiectomy. Pathologic examination of the mass revealed medium to large calibre thick-walled blood vessels with ectatic lumina, surround  by sclerotic, fibrous smooth muscle bundles in a fatty milieu. Immunohistochemistry of the lesion demonstrated positive staining for smooth muscle actin (SMA+) and endothelial marker CD34. The lesion did not, however, stain positively for smooth muscle antigen S100 or melanocytic antigen HMB-45.

 

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[416]

TÍTULO / TITLE:  - A huge cemento-ossifying fibroma of paranasal sinus: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Medica (Hradec Kralove). 2012;55(3):146-9.

AUTORES / AUTHORS:  - Erdim I; Yazici ZM; Yilmazer R; Sever N; Kayhan FT

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology, Bakirkoy Dr. Sadi Konuk Training and Research  Hospital, Istanbul, Turkey. ibrahim_erdim@hotmail.com

RESUMEN / SUMMARY:  - Cemento-ossifying fibroma is a well-bordered, slow-growing, benign fibro-osseous  disease. Although its localization is generally in the mandible, it can be seen in any area of the craniofacial region. Radiology and histopathology help to diagnose the condition. Treatment is based on close observation and/or surgical excision. In this case, we report the case of a 62-year-old male patient who had  a large radiological appearance, cemento-ossifying fibroma in the paranasal sinuses.

 

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[417]

TÍTULO / TITLE:  - Peripheral ossifying fibroma: case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - N Y State Dent J. 2012 Jun-Jul;78(4):52-5.

AUTORES / AUTHORS:  - Pradeep AR; Guruprasad CN; Agarwal E

INSTITUCIÓN / INSTITUTION:  - periodontics_gdc@rediffmail.com

RESUMEN / SUMMARY:  - We present a case of peripheral ossifying fibroma (POF) in a 17-year-old boy. Clinical, radiographic and histologic characteristics are discussed and recommendations regarding differential diagnosis, treatment and follow-up are provided. Lesions histologically similar to POF have been given various names in  the existing literature; therefore, the controversial varied nomenclature and possible etiopathogenesis of POF are discussed. A slowly growing soft tissue mass with speckled calcifications in the anterior oral cavity of children or young adults should raise the suspicion of a reactive gingival lesion such as POF.

 

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[418]

TÍTULO / TITLE:  - Osteoid osteoma of the talar neck.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JBR-BTR. 2012 Sep-Oct;95(5):335.

AUTORES / AUTHORS:  - Cornelissen L; Schepers S

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, University Hospitals Leuven, Leuven, Belgium.

 

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[419]

TÍTULO / TITLE:  - Prognostic and therapeutic relevance of the IGF pathway in Ewing’s sarcoma patients.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Target Oncol. 2013 Jan 6.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11523-012-0248-3

AUTORES / AUTHORS:  - van de Luijtgaarden AC; Versleijen-Jonkers YM; Roeffen MH; Schreuder HW; Flucke UE; van der Graaf WT

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Radboud University Medical Centre, Internal postal code 452, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

RESUMEN / SUMMARY:  - The optimal target and timing of drugs interfering with the insulin-like growth factor (IGF) signaling system in Ewing’s sarcoma (ES) remain undetermined. We examined the expression of IGF signaling proteins in ES samples taken before and  after chemotherapy, and speculate about the optimal way of treating ES patients in the future. Tumor material (36 initial biopsies and 24 resection specimens after neoadjuvant chemotherapy) and follow-up data of 41 patients treated for ES  at the Radboud University Nijmegen Medical Centre were analyzed. Immunohistochemical staining was done for IGF1, IGF2, IGFBP3, IGF-1R, phosphorylated AKT (pAKT), phosphorylated mTOR (pmTOR), and phosphorylated ERK (pERK), and staining intensity was scored semiquantitatively. Change of protein expression during treatment, correlations of effector cascade signaling, and influence on progression-free (PFS) and overall survival (OS) were tested. All potential targets were widely expressed at both time points. After chemotherapy,  pmTOR expression decreased significantly (p = 0.021) while IGFBP3 increased (p =  0.005). Correlations exist between IGF-1R and pERK (rho = 0.286, p = 0.031), IGF-1R and pAKT (rho = 0.269, p = 0.045), pAKT and pERK (rho = 0.460, p = 0.000), and pERK and pmTOR (rho = 0.273, p = 0.038). In therapy-naive samples, combined expression of pAKT, pmTOR, and pERK predicted worse PFS (median, 11 vs. 32 months; p = 0.039) and OS (median, 18 vs. 83 months; p = 0.023). We identify an unfavorable prognostic group of ES patients with widely activated IGF-effector cascades, demonstrate cooperation between the different downstream pathways, and  show how expression of IGF-related proteins may change after exposure to chemotherapy. These findings should be taken into account when designing future trials with IGF-targeting agents. We suggest the prospective exploration of chemotherapy and multi-target tyrosine kinase inhibitors in the first-line setting.

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[420]

TÍTULO / TITLE:  - Gummy smile: could it be genetic? Hereditary gingival fibromatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Mich Dent Assoc. 2012 Dec;94(12):40-3.

AUTORES / AUTHORS:  - Livada R; Shiloah J

INSTITUCIÓN / INSTITUTION:  - Department of Periodontics, College of Dentistry, University of Tennessee Health  Science Center, Memphis, Tennessee, USA. rlivada@uthsc.edu

RESUMEN / SUMMARY:  - Gingival enlargement is common among patients and can be caused by a variety of etiological factors. The most common reason is poor oral hygiene and high bacterial load that leads to gingival inflammation and enlargement. Other implicated factors include systemic drugs, such as Phenytoin (Dilantin) taken by  epileptic patients, Calcium Channel Blockers such as Nifedipine (Procardia) and Verapamil (Calan) for the treatment of hypertension, arrhythmia and angina. Another class of medication associated with gingival enlargement is immunosuppressive agents given to organ-transplant patients to prevent rejection  of the new element, such as Cyclosporine. Some enlargements could be associated with other conditions such as puberty, pregnancy or diabetes or be a symptom of a systemic disease (leukemia, Wegener’s granulomatosis or sarcoidosis). In rare cases the cause for the enlargement is genetic and termed Hereditary Gingival Fibromatosis (HGF). HGF is a genetic disorder characterized by a progressive enlargement of the gingiva. Histologically, the gingiva is characterized by an accumulation of dense fibrous connective tissue. This is believed to be due to an imbalance between synthesis and degradation of extracellular matrix composed mainly of collagen molecules or due to an alteration in fibroblast proliferation. Different pathogenic mechanisms have been proposed and examined over the years but no precise process has been identified. The main objective of this paper is to discuss this genetic anomaly and support it with clinical cases of a mother and her two children. It will focus on the clinical and histologic characteristics of HGF as well as known biologic and genetic features and treatment modalities.

 

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[421]

TÍTULO / TITLE:  - Survival trends and long-term toxicity in pediatric patients with osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2012;2012:636405. doi: 10.1155/2012/636405. Epub 2012 Nov 25.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/636405

AUTORES / AUTHORS:  - Hagleitner MM; de Bont ES; Te Loo DM

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Hematology and Oncology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

RESUMEN / SUMMARY:  - Background. This study was conducted to investigate the clinical characteristics  and treatment results of osteosarcoma in pediatric patients during the past 30 years. Trends in survival rates and long-term toxicity were analyzed. Procedure.  130 pediatric patients under the age of 20 years with primary localized or metastatic high-grade osteosarcoma were analyzed regarding demographic, treatment-related variables, long-term toxicity, and survival data. Results. Comparison of the different time periods of treatment showed that the 5-year OS improved from 58.6% for children diagnosed during 1979-1983 to 78.6% for those diagnosed during 2003-2008 (P = 0.13). Interestingly, the basic treatment agents  including cisplatin, doxorubicin, and methotrexate remained the same. Treatment reduction due to acute toxicity was less frequent in patients treated in the last era (7.1% versus 24.1% in patients treated in 1979-1983; P = 0.04). Furthermore,  late cardiac effects and secondary malignancies can become evident many years after treatment. Conclusion. We elucidate the prevalence of toxicity to therapy of patients with osteosarcoma over the past 30 years. The overall improvement in  survival may in part be attributed to improved supportive care allowing regimens  to be administered to best advantage with higher tolerance of chemotherapy and therefore less chemotherapy-related toxicity.

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[422]

TÍTULO / TITLE:  - Oral pathology quiz #77. Case number 2. Giant cell fibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J N J Dent Assoc. 2012 Fall;83(4):17, 20.

 

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[423]

TÍTULO / TITLE:  - Oral pathology quiz #77. Case number 3. Odontogenic myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J N J Dent Assoc. 2012 Fall;83(4):17, 20.

 

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[424]

TÍTULO / TITLE:  - Endoscopic management of uterine fibroids: an update.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Minerva Ginecol. 2012 Dec;64(6):507-20.

AUTORES / AUTHORS:  - Soto E; Flyckt R; Falcone T

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics, Gynecology and Women’s Health Institute, Cleveland Clinic, Cleveland, OH, USA - falcont@ccf.org.

RESUMEN / SUMMARY:  - Recent technological advances in endoscopy have allowed gynecological surgeons to expand the operative approaches that can be utilized in the conservative management of uterine myomas. Commonly used approaches in gynecological practice  now include laparoscopic myomectomy, laparoscopic-assisted myomectomy through a mini-laparotomy incision and robotic-assisted laparoscopic myomectomy. Adequate preoperative evaluation with careful selection of the best operative approach for each particular patient constitutes the basis of safe and effective surgery for the operative management of uterine myomas.

 

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[425]

TÍTULO / TITLE:  - Bilateral Mediastinal Neurofibroma of the Vagus Nerves in a Patient with Neurofibromatosis Type 1.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2012 Nov 17.

AUTORES / AUTHORS:  - Kanzaki R; Inoue M; Minami M; Sawabata N; Shintani Y; Nakagiri T; Okumura M

INSTITUCIÓN / INSTITUTION:  - Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

RESUMEN / SUMMARY:  - Bilateral mediastinal vagus neurogenic tumors are very rare. We herein report the case of Neurofibromatosis type 1 (NF-1) patient with bilateral neurofibromas originating from the mediastinal vagus just distal site of the recurrent nerve, who underwent two-staged extirpations that successfully preserved both recurrent  nerves. A 31-yearold female with a history of NF-1 was admitted to our hospital under a diagnosis of multiple tumors in the upper mediastinum. First, the tumor at the right paratracheal to precarinal site was completely resected through a median sternotomy, preserving the right recurrent nerve. After confirming no right recurrent nerve paralysis, thoracoscopic resection of the tumor at the aorto-pulmonary window was then performed preserving the left recurrent nerve. The histopathological diagnosis was neurofibroma originating from the bilateral mediastinal vagus nerves. A two-staged operation can be an option in cases with bilateral mediastinal vagus nerve tumors to avoid the risk of bilateral recurrent nerve paralysis.

 

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[426]

TÍTULO / TITLE:  - Gluteal angiosarcoma presenting as sciatica: An unusual secondary cause.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Joint Bone Spine. 2012 Dec 10. pii: S1297-319X(12)00280-1. doi: 10.1016/j.jbspin.2012.10.011.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jbspin.2012.10.011

AUTORES / AUTHORS:  - Burke NG; Muhammad Bilal M; Harrington P

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Our Lady of Lourdes Hospital, Drogheda, Ireland. Electronic address: nei1burke@yahoo.co.uk.

 

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[427]

TÍTULO / TITLE:  - Spindle cell rhabdomyosarcoma of the prostate.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Urol. 2013 Jan 16. doi: 10.1111/iju.12082.

            ●● Enlace al texto completo (gratuito o de pago) 1111/iju.12082

AUTORES / AUTHORS:  - Latz S; Ellinger J; Goltz D; Marx C; Leuschner I; Muller SC; Fechner G

INSTITUCIÓN / INSTITUTION:  - Department of Urology, University of Bonn, Bonn.

RESUMEN / SUMMARY:  - The spindle cell rhabdomyosarcoma is a rare variant of the embryonal rhabdomyosarcoma, mostly occurring in childhood. Only a few cases are described in adults. To date, no case of the spindle cell subtype of the prostatic embryonal rhabdomyosarcoma has been published. We report on a 23-year-old man, initially presenting with obstructive micturition problems, perineal pain and night sweat. After diagnosis by transrectal biopsy of the prostate, radiochemotherapy within the CWS 2002 P study was applied: nine cycles of vincristine, doxorubicin, actinomycin D, ifosfamide, and fractionated radiotherapy of the tumor and suspect lymph nodes (final dose 50.4 Gy). The tumor initially shrank, but an early local recurrence arose. Second-line chemotherapy was applied, followed by a salvage radical cytoprostatectomy. The patient died of disseminated disease 14 months after diagnosis.

 

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[428]

TÍTULO / TITLE:  - Incidental finding of inflammatory fibroid polyp of the appendix in a patient presenting with acute appendicitis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Gastroenterol. 2013 Jan 9.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12664-012-0292-z

AUTORES / AUTHORS:  - Ali WA; Mahmud AM; Keloth TR

INSTITUCIÓN / INSTITUTION:  - General Surgery Department, Rashid Hospital, Dubai, United Arab Emirates, waddahabdelazim@hotmail.com.

 

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[429]

TÍTULO / TITLE:  - Pharmacological profile and clinical results in advanced soft tissue sarcoma patients of pazopanib hydrochloride (Votrient(®)).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nihon Yakurigaku Zasshi. 2013 Jan;141(1):37-42.

AUTORES / AUTHORS:  - Arai H; Fukasawa N; Ueta F

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[430]

TÍTULO / TITLE:  - Development of a Nephrotic Syndrome in a Patient with Gastrointestinal Stromal Tumor during a Long-Time Treatment with Sunitinib.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol. 2012 Sep;5(3):651-6. doi: 10.1159/000345946. Epub 2012 Dec 6.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000345946

AUTORES / AUTHORS:  - Pallotti MC; Pantaleo MA; Nannini M; Centofanti F; Fabbrizio B; Montanari M; Baraldi O; Saponara M; Lolli C; Mandrioli A; Biasco G; Prandini R

INSTITUCIÓN / INSTITUTION:  - Department Institute of Hematology and Medical Oncology ‘L. and A. Seragnoli’, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

RESUMEN / SUMMARY:  - A patient with advanced gastrointestinal stromal tumor (GIST) receiving second-line treatment with sunitinib developed edema, increase of the serum creatinine, weight gain, nephrotic syndrome with proteinuria of 12 g/24 h, dyslipidemia, hypoalbuminemia and also presented with hypertension. A kidney biopsy showed an immunocomplex glomerulonephritis. Steroid treatment was started, but the clinical conditions and laboratory values did not improve. So in the hypothesis that the nephrotic syndrome was induced by sunitinib, sunitinib was temporarily discontinued with a subsequent reduction of proteinuria and improvement in blood pressure control. In the last years, the introduction of sunitinib has modified the natural history of advanced GIST. However, due to chronic and prolonged intake of this drug, there is increasingly frequent detection of late and unknown toxicities in clinical practice. In particular, the late renal toxicity from sunitinib may be the primary clinical problem with this  drug in the case of prolonged treatment. Monitoring of kidney function and blood  pressure should be performed for early detection of side effects such as hypertension and kidney dysfunction in advanced GIST patients receiving long-term treatment with sunitinib. A clinical collaboration between oncologists and nephrologists could be useful with the objective to optimize the management of sunitinib.

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[431]

TÍTULO / TITLE:  - Extra Gastrointestinal Stromal Tumor treated with imatinib in a patient with Neurofibromatosis type 1.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Oncol. 2012 Dec;3(4):373-6. doi: 10.3978/j.issn.2078-6891.2012.034.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2078-6891.2012.034

AUTORES / AUTHORS:  - Malhotra A; Wright J; Gajra A

INSTITUCIÓN / INSTITUTION:  - SUNY Upstate Medical University Syracuse, New York, USA.

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[432]

TÍTULO / TITLE:  - Ruptured cardiac angiosarcoma with pulmonary metastases: A rare disease with a common (mis)diagnosis!

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian Heart J. 2012 Nov-Dec;64(6):603-6. doi: 10.1016/j.ihj.2012.07.016. Epub 2012 Jul 27.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ihj.2012.07.016

AUTORES / AUTHORS:  - Jain G; Mukhopadhyay S; Kurien S; Yusuf J; Tyagi S; Jain R

INSTITUCIÓN / INSTITUTION:  - Assistant Professor, Dept. of Cardiology, GB Pant Hospital, New Delhi 110002, India. Electronic address: kirti_kota@yahoo.com.

RESUMEN / SUMMARY:  - In Indian settings pulmonary tuberculosis remains the most common diagnosis in a  patient presenting with constitutional symptoms, hemoptysis and lung opacities. We describe a case report of a fifty-year-old woman who was receiving empirical anti-tubercular drugs for a metastatic illness to lungs arising from a primary angiosarcoma in the right atrium. This rare entity was misdiagnosed and typical echocardiographic findings suggested this diagnosis.

 

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[433]

TÍTULO / TITLE:  - Protein Profiling of Blood Samples from Patients with Hereditary Leiomyomatosis and Renal Cell Cancer by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Mol Sci. 2012 Nov 8;13(11):14518-32. doi: 10.3390/ijms131114518.

            ●● Enlace al texto completo (gratuito o de pago) 3390/ijms131114518

AUTORES / AUTHORS:  - Kamai T; Tomosugi N; Abe H; Kaji Y; Oyama T; Yoshida K

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Dokkyo Medical University, Tochigi 321-0293, Japan. kamait@dokkyomed.ac.jp.

RESUMEN / SUMMARY:  - Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an extremely rare syndrome with autosomal dominant inheritance. HLRCC is characterized by a predisposition to leiomyomas of the skin and the uterus as well as renal cell carcinoma. The disease-related gene has been identified as fumarate hydratase (fumarase, FH), which encodes an enzyme involved in the mitochondrial tricarboxylic acid cycle. Protein profiling may give some insight into the molecular pathways of HLRCC. Therefore, we performed protein profiling of blood samples from HLRCC patients, their family members, and healthy volunteers, using  surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) coupled with IMAC-Cu chips. For hierarchical clustering analysis,  we used the 45 peaks that revealed significant differences in single-marker analysis over the range from 1500 to 15,000 m/z. Heat map analysis based on the results of clustering distinguished the HLRCC kindred from non-HLRCC subjects with a sensitivity of 94% and a specificity of 90%. SELDI-TOF MS profiling of blood samples can be applied to identify patients with HLRCC and to assess specific molecular mechanisms involved in this condition.

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[434]

TÍTULO / TITLE:  - Prospective evaluation of cisplatin- and carboplatin-mediated ototoxicity in paediatric and adult soft tissue and osteosarcoma patients.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Jan;5(1):311-315. Epub 2012 Oct 25.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.997

AUTORES / AUTHORS:  - Nitz A; Kontopantelis E; Bielack S; Koscielniak E; Klingebiel T; Langer T; Paulides M

INSTITUCIÓN / INSTITUTION:  - Department of Paediatric Oncology and Immunology, LESS Centre, University Hospital for Children and Adolescents, Erlangen D-91054, Germany ;

RESUMEN / SUMMARY:  - Platinum-compound chemotherapy is known to have ototoxic side-effects. However, there is a paucity of literature examining hearing function prospectively and longitudinally in cohorts containing paediatric and adult patients treated within the same cisplatin- or carboplatin-containing treatment trial protocols. In Germany, Austria and Switzerland, late effects of treatment for osteosarcoma and  soft tissue sarcoma have been prospectively and longitudinally registered by the  Late Effects Surveillance System since 1998. The aim of this study was to analyse cisplatin- and carboplatin-induced ototoxity in a group of 129 osteosarcoma and soft tissue sarcoma patients treated within the COSS-96, CWS-96 and CWS-2002P treatment trials. The cohort consisted of 112 children and 17 adults. The median  age at diagnosis was 13.56 (IQR, 10.26-16.27) years. Follow-up was 6.97 (IQR, 0.87-15.63) months. Hearing function was examined by audiometry before and after  platinum treatment. A total of 108 patients were treated with cisplatin with a median cumulative dose of 360 mg/m(2). Thirteen patients received carboplatin with a median cumulative dose of 1500 mg/m(2) and 8 patients were treated with both platinum compounds (median cisplatin dose, 240 mg/m(2); IQR, 240-360 mg/m(2) and median carboplatin dose: 1200 mg/m(2); IQR, 600-3000 mg/m(2)). Following cessation of therapy, 47.3% of the patients demonstrated a hearing impairment, namely 55 children (49.1%) and 6 adults (42.1%). Out of thirteen children treated with carboplatin with a cumulative dose of 1500 mg/m(2), six revealed a significant hearing impairment. Although ototoxicity caused by platinum compounds is considered irreversible, we identified hearing improvements over time in 11 children (9.8%) and 3 adults (17.6%). None of these patients received irradiation to the head. We conclude that hearing loss is frequent in children treated with protocols containing platinum compounds and recommend prospective testing via audiometry.

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[435]

TÍTULO / TITLE:  - Effect of mesenchymal stem cells on hypoxia-induced desensitization of beta2-adrenergic receptors in rat osteosarcoma cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2012 Oct;4(4):745-750. Epub 2012 Jul 19.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.813

AUTORES / AUTHORS:  - Kido A; Yoshitani K; Shimizu T; Akahane M; Fujii H; Tsukamoto S; Kondo Y; Honoki K; Imano M; Tanaka Y

INSTITUCIÓN / INSTITUTION:  - Departments of Orthopedic Surgery and.

RESUMEN / SUMMARY:  - The beta2-adrenergic receptor (beta2AR) mediates the effects of chronic stress in several neoplasms, however, beta2AR signaling is impaired by hypoxia in various tissues. While hypoxia is a common feature significant in the progression of solid tumors, little is known about the effect of hypoxia on beta2AR signaling in the tumor microenvironment. Previously, it has been reported that the systemic administration of mesenchymal stem cells (MSCs) increased the engraftment and metastatic colonization of rat osteosarcoma (OS) cells. In the current study, the effect of MSCs on the hypoxia-induced desensitization of the beta2AR in OS cells  was investigated. Epinephrine, norepinephrine and isoproterenol increased the cellular proliferation of the rat OS cell line COS1NR and rat MSCs in a dose-dependent and beta2AR antagonist-sensitive manner. While isoproterenol had significant proliferative effects on MSCs under normoxic and hypoxic conditions,  COS1NR cells did not respond under hypoxic conditions. A sensitivity assay for the beta2AR revealed that hypoxia impaired the sensitivity of COS1NR cells, whereas hypoxia did not affect MSCs. An immunoassay revealed no significant change in the expression of hypoxia-inducible factor-1alpha (HIF1alpha) in COS1NR cells, whilst an immunoassay demonstrated a 15% increase in MSCs following isoproterenol stimulation. In COS1NR cells co-cultured with MSCs under hypoxic conditions, isoproterenol caused a significant increase in proliferation and this effect was inhibited by an anti-interleukin (IL)-6 antibody. A tumor formation assay in syngeneic rats revealed that the systemic administration of MSCs enhances the growth of OS and the effect of MSCs was inhibited by IL-6 neutralization. In conclusion, MSCs are resistant to the hypoxia-induced desensitization to beta2AR. Hypoxia caused a siginificant desensitization of the  beta2AR in COS1NR cells alone, whereas MSCs may support tumor progression through cellular interactions.

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[436]

TÍTULO / TITLE:  - Oral lipoma in elderly saudi patient: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Health Sci (Qassim). 2012 Jan;6(1):97-103.

AUTORES / AUTHORS:  - Ikram R; Rehman Al-Eid AA

INSTITUCIÓN / INSTITUTION:  - Consultant Oral&Maxillo-facial Surgeon. Buraidah Central Hospital, Al-Qassim, KSA. E-Mail: drrashid79@hotmail.com Mobile: +966551866583.

RESUMEN / SUMMARY:  - Lipomas are relatively uncommon benign tumor occurring in the oral cavity with a  prevalence rate of 1% to 4% of all oral lesions. They present as a slow growing,  painless, asymptomatic submucosal mass and surgical excision is the treatment of  choice. Oral lipomas have been known to grow to large sizes causing interference  with speech, mastication and construction of denture. A case of 77 years old male patient with lipoma of buccal mucosa in oral cavity which exhibited a sudden growth after a lag time of 3 years with mastication and speech difficulties. The  tumor excised in total with restoration of normal speech and mastication.

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[437]

TÍTULO / TITLE:  - Leiomyoma of the gallbladder in a patient with metastatic gastrointestinal stromal tumor in the liver: A case report with differential diagnostic considerations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2012 Dec;4(6):1171-1173. Epub 2012 Sep 12.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.910

AUTORES / AUTHORS:  - Ishida M; Shiomi H; Naka S; Tani T; Okabe H

INSTITUCIÓN / INSTITUTION:  - Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology;

RESUMEN / SUMMARY:  - Mesenchymal tumor of the gallbladder is rare and the majority of cases present as sarcomas. Benign mesenchymal tumors of the gallbladder are extremely rare and to  date, only one case of leiomyoma has been reported. In this report, we describe a second case of leiomyoma of the gallbladder, and discuss the differential diagnostic considerations. A 55-year-old female with metastatic gastrointestinal  stromal tumors (GISTs) in the liver was identified to possess a tumorous lesion of the gallbladder. The patient had previously received a partial gastrectomy for GIST, and multiple liver metastases were revealed. Following surgery, imatinib was administered, and the liver metastatic lesions were stabilized. Histopathological analysis of the resected gallbladder specimens revealed that the nodule arose from the muscular layer, and was composed of spindle cell proliferation with eosinophilic cytoplasm and bland cigar-shaped nuclei. Mitotic  figures were rarely noted, and necrosis was not observed. Immunohistochemical analyses demonstrated that the tumor cells were positive for desmin and alpha-smooth muscle actin, but negative for CD117 and CD34. In accordance with these results, a final diagnosis of leiomyoma of the gallbladder was made. The present case is unique since the patient possessed multiple metastatic GISTs in the liver, and the gallbladder nodule was preoperatively suspected to be a metastatic GIST. Leiomyoma of the gallbladder is extremely rare; however, it may  be an underrecognized entity. Thus, it is important to differentiate leiomyoma from GIST to avoid unnecessary clinical follow-up and treatment.

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[438]

TÍTULO / TITLE:  - Left atrial myxoma presenting with cerebral embolism.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Health R I. 2012 Dec;95(12):397.

AUTORES / AUTHORS:  - Earl TJ; Poppas A

INSTITUCIÓN / INSTITUTION:  - Warren Alpert Medical School of Brown University, USA. tearl@lifespan.org

 

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[439]

TÍTULO / TITLE:  - Multiple Jejunal Myeloid Sarcomas Presenting with Intestinal Obstruction in a Non-leukemic Patient: A Case Report with Ultrastructural Observations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Pathol. 2012 Dec;46(6):590-4. doi: 10.4132/KoreanJPathol.2012.46.6.590.  Epub 2012 Dec 26.

            ●● Enlace al texto completo (gratuito o de pago) 4132/KoreanJPathol.2012.46.6.590

AUTORES / AUTHORS:  - Kim NR; Lee WK; Lee JI; Cho HY

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.

RESUMEN / SUMMARY:  - Myeloid sarcoma is a rare extramedullary myeloid tumor, which is frequently misdiagnosed when no evidence of leukemia is initially observed. Here, we report  on a peculiar case of a 49-year-old man afflicted with multiple masses in the jejunum, the superior mesentery, and the serosa of the transverse colon, without  leukemic manifestation. The tumor was composed of undifferentiated small round cells containing eosinophilic cytoplasm, which were negative for myeloperoxidase, nonspecific esterase, lysozyme, terminal deoxynucleotidyl transferase, leukocyte  common antigen, CD3, CD4, CD15, CD20, CD30, CD43, CD56, CD68/PG-M1, CD79a, human  melanoma black-45, c-kit, and CD34 with positivity only for CD68/KP1, CD99, and vimentin. Under electron microscopy, those cells had abundant membrane-bound cytoplasmic granules that measured 200 to 300 nm in diameter, which were consistent with granulocytic azurophilic granules. The tumor was finally diagnosed as a myeloid sarcoma. The presence of non-leukemic myeloid sarcomas showing immunonegativity for conventional myeloid-leukemic markers necessitated a diagnosis by ultrastructural observation.

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[440]

TÍTULO / TITLE:  - Synchronous plexiform neurofibroma in the arytenoids and neurofibroma in the parapharynx in a patient with non-neurofibromatosis: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Case Rep. 2013 Jan 10;7(1):15. doi: 10.1186/1752-1947-7-15.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1752-1947-7-15

AUTORES / AUTHORS:  - Son HY; Shim HS; Kim JP; Woo SH

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology, Gyeongsang National University, Jinju, Korea. lesaby@hanmail.net.

RESUMEN / SUMMARY:  - ABSTRACT: INTRODUCTION: Plexiform neurofibroma of the larynx is a rare disease. In this report, we present a plexiform neurofibroma in the arytenoids and neurofibroma in the parapharynx detected coincidently. CASE PRESENTATION: A 56-year-old Asian woman presented with respiratory distress and episodes of apnea at night. A solitary mass from the left arytenoids was found to be nearly obstructing the airway and causing the sleep apnea. There was also a parapharynx  mass protruding into the pharynx. The parapharynx tumor was removed with the lateral incision approach, and the arytenoid tumor was removed with a transoral carbon dioxide laser. The pathologic diagnosis was plexiform neurofibroma for the arytenoid mass and neurofibroma for the parapharynx mass. CONCLUSION: We have reported an extremely rare case of plexiform neurofibroma in the arytenoids and neurofibroma in the parapharynx. This entity may be considered in the differential diagnosis of all laryngeal and parapharynx masses.

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[441]

TÍTULO / TITLE:  - Management of imatinib-associated skin rash in a patient with metastatic gastrointestinal stromal tumor: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Sarcoma Res. 2012 Dec 4;2(1):23. doi: 10.1186/2045-3329-2-23.

            ●● Enlace al texto completo (gratuito o de pago) 1186/2045-3329-2-23

AUTORES / AUTHORS:  - Blay JY

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Centre Leon-Berard, 28 rue Laennecx, Lyon28 rue Laennec, Lyon 69008, France. jean-yves.blay@lyon.unicancer.fr.

RESUMEN / SUMMARY:  - ABSTRACT: PURPOSE: Long-term continuous imatinib is recommended for adult patients with unresectable and/or metastatic KIT+ gastrointestinal stromal tumors (GIST) as long as the patient continues to benefit. In the adjuvant setting, recent findings indicate that patients at considerable risk of recurrence should  receive at least 3 years of imatinib. Because imatinib is often administered for  prolonged periods, proper management of imatinib-associated adverse events is crucial. CASE REPORT: We report a 56-year-old man with metastatic KIT+ GIST of the liver who had Grade 3 imatinib intolerance (skin rash) when treatment was started. The rash was managed with antihistamine treatment (Dexchlorpheniramine maleate 4 mg per day) and several temporary (up to 2 weeks) dose interruptions. The patient’s skin rash partially improved, and he tolerated gradual reintroduction of imatinib over several months. The patient maintained imatinib 400 mg/d, and tolerated it during the 2 years when he was on antihistamine treatment. After 2 years, the patient continued imatinib therapy without having to take antihistamines. The patient responded according to RECIST 1.1 and Choi to imatinib treatment for his metastatic GIST (partial response). As of September, 2012, the patient has been on imatinib therapy for 131 months and remains progression free. CONCLUSIONS: The results of this case report demonstrated that  a patient with metastatic KIT+ GIST who was initially intolerant to imatinib maintained, and responded to imatinib therapy after treatment of an imatinib-associated adverse effect. These results suggest that initial intolerance to imatinib should not necessarily result in treatment discontinuation, as these adverse effects, when managed properly, may be tolerated and may decrease over time.

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[442]

TÍTULO / TITLE:  - Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Case Rep. 2013 Jan 9;7(1):11. doi: 10.1186/1752-1947-7-11.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1752-1947-7-11

AUTORES / AUTHORS:  - Schutt RC; Gordon TA; Bhabhra R; Cathro HP; Cook SL; McCartney CR; Weiss GR

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, University of Virginia, PO Box 800696, Charlottesville, VA, 22908, USA. rob.schutt@virginia.edu.

RESUMEN / SUMMARY:  - ABSTRACT: INTRODUCTION: Doege-Potter syndrome is a paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. This tumor causes hypoglycemia by the secretion of a prohormone form of insulin-like growth factor II. We describe the diagnosis and management of Doege-Potter syndrome and the use of transarterial chemoembolization in a patient with a malignant extrapleural solitary fibrous tumor. CASE PRESENTATION:  Our patient was a 64-year-old Caucasian woman who initially presented with urinary incontinence and was found to have a 14.5x9.0x9.0cm retroperitoneal solitary fibrous tumor compressing her bladder. Her tumor was surgically resected but recurred with multiple hepatic metastatic lesions. The hepatic metastases progressed despite systemic chemotherapy and treatment with doxorubicin transarterial chemoembolization. Her course was complicated by the development of recurrent fasting hypoglycemia, most likely secondary to Doege-Potter syndrome. Her hypoglycemia was managed with corticosteroid therapy and frequent scheduled nutrient intake overnight. CONCLUSIONS: The rarity of hepatic solitary fibrous tumors and consequent lack of controlled trials make this report significant in that it describes the diagnostic approach to Doege-Potter syndrome, describes our experience with the use of doxorubicin transarterial chemoembolization, and presents management options for tumor-associated hypoglycemia in the case of extensive disease not amenable to surgical resection.

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[443]

TÍTULO / TITLE:  - CPT-11 Chemotherapy Rescued A Patient with Atypical Sclerosing Epithelioid Fibrosarcoma from Emergent Condition.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chin J Cancer Res. 2012 Sep;24(3):253-6. doi: 10.1007/s11670-012-0253-1.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11670-012-0253-1

AUTORES / AUTHORS:  - Pan CH; Han XQ; Li JS

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, China.

RESUMEN / SUMMARY:  - Sclerosing epithelioid fibrosarcoma (SEF) is a rare and poorly defined variant of fibrosarcoma, but generally insensitive to chemotherapy and progresses with poor  prognosis. We report the marvelous effect of irinotecan hydrochloride (CPT-11) chemotherapy in rescuing a patient with atypical SEF from emergent condition, who underwent recurrences after several treatment methods. Small dose of CPT-11 was administered to the patient, with which, the size of superficial mass (cervical lymph node) gradually decreased observed by the naked eyes in 5 days. X-ray and CT image proved a marked reduction in the size of the tumor. CPT-11 is valuable for the treatment of this aggressive sarcoma. In condition of emergency caused by sarcoma oppression, administering a tolerable small dose of topoisomerase I-inhibiting drug could be a beneficial choice.

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[444]

TÍTULO / TITLE:  - The outcomes of treatment of giant cell tumor of bone around the knee.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Assoc Thai. 2012 Sep;95 Suppl 9:S122-8.

AUTORES / AUTHORS:  - Asavamongkolkul A; Eamsobhana P; Waikakul S; Phimolsarnti R

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. siaas@mahidol.ac.th

RESUMEN / SUMMARY:  - BACKGROUND: Giant cell tumor of bone has been characterized as an aggressive benign bone tumor and commonly occurs at the distal femur and the proximal tibia. The recommended treatment has ranged from intralesional curettage to wide excision and the decision depends on severity of the tumor extent, rate of local  recurrence,functional and morbidity outcomes. OBJECTIVE: To compare extended curettage and wide excision in Grade II-III giant cell tumor of bone around the knee with regard to their effectiveness in tumor control and complication. MATERIAL AND METHOD: There were 54 patients with a giant cell tumor which involved the distal femur or proximal tibia who had been managed consecutively at Siriraj Hospital between 1994-2009. The lesion of all patients were staged according to the system of Campanacci et al. There were 21 males and 33 females with mean age of 34 years. Thirty-five tumors located at distal femur and 19 located at proximal tibia. Fourteen patients had a Grade II lesion and 40 had a Grade III lesion. Thirty patients received extended curettage whereas other 24 patients had a wide excision. Fisher’s exact analysis was used for statistical analysis for the outcome of tumor recurrence in each surgery. RESULTS: The mean follow-up time was 59 months. There were 7 (23.3 percent) local recurrences in the extended curettage group and 2 (8.3 percent) in the wide excision group. Most recurrences occurred within one year postoperatively. There was no statistical difference for the outcome of tumor recurrence in each group (p = 0.270). All patients with tumor recurrence were successfully treated with re-curettage, except for 3 patients who was treated by above-knee amputation. The functional analysis was excellence in the extended curettage group (94 percent) and good in  the wide excision group (77.6 percent) according to the Musculoskeletal Tumor Society functional classification. CONCLUSION: The authors believe that using extended curettage was not significantly different in percentage of local recurrence when compared with wide excision for Campanacci’s Grade II-III of giant cell tumor of bone. Even better function was found in extended curettage group, the choice of surgical treatment should be considered in individual patient which depends on the extent of bone destruction and risk of tumor recurrence.

 

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[445]

TÍTULO / TITLE:  - False-Negative Results of Endoscopic Biopsy in the Diagnosis of Gastrointestinal  Kaposi’s Sarcoma in HIV-Infected Patients.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Patholog Res Int. 2012;2012:854146. doi: 10.1155/2012/854146. Epub 2012 Nov 26.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/854146

AUTORES / AUTHORS:  - Nagata N; Sekine K; Igari T; Hamada Y; Yazaki H; Ohmagari N; Akiyama J; Shimbo T; Teruya K; Oka S; Uemura N

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma (KS) is a rare endothelial neoplasm mainly involving the skin, but it is often associated with AIDS. Diagnosis of gastrointestinal (GI) tract KS, a common site of visceral involvement in AIDS, is important, but endoscopic biopsy carries a risk of false-negative results (FNRs) due to its submucosal appearance. This study sought to determine the rate and causes of FNR for endoscopic biopsy of GI-KS lesions. Endoscopic biopsy samples of 116 GI-KS lesions were reviewed retrospectively. All GI-KS lesions were confirmed to be resolved following KS therapy. FNRs were yielded for 41 of the lesions (35.3%). Among upper and lower GI sites, the esophagus was the only site significantly associated with FNRs (P < 0.01). Small size (<10 mm) and patches found on endoscopy were significantly associated with FNRs (P < 0.05). Findings of submucosal tumor (SMT) with ulceration were significantly associated with true-positive results (P < 0.05). In conclusion, FNRs were found in 35.3% of GI-KS lesions and were especially related to the site of the esophagus and endoscopic early stage (small size or patch appearance). An SMT with ulceration may be relatively easy to diagnose on endoscopic biopsy. Caution should be exercised when performing endoscopic biopsy of these lesions in AIDS patients and evaluating the histological features.

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[446]

TÍTULO / TITLE:  - Primary osteosarcoma arising from the middle turbinate in a pediatric patient.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Exp Otorhinolaryngol. 2012 Dec;5(4):237-9. doi: 10.3342/ceo.2012.5.4.237. Epub 2011 Sep 15.

            ●● Enlace al texto completo (gratuito o de pago) 3342/ceo.2012.5.4.237

AUTORES / AUTHORS:  - Kim YJ; Kim YJ; Chu YC; Lee JW; Jeon YS; Lee KH; Cho SG; Kim MY

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Inha University College of Medicine, Incheon, Korea.

RESUMEN / SUMMARY:  - Osteosarcomas usually occur as secondary tumors after radiation therapy or chemotherapy. Without a history of irradiation to the head and neck area, primary osteosarcoma of the turbinate is extremely rare. We report here a rare case of primary turbinate osteosarcoma presenting as a relatively small, well-circumscribed, turbinate mass. Its appearance mimicked a benign nasal mass like mucocele and polyp. We also reviewed the previously reported cases of tumor  arising from turbinate.

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[447]

TÍTULO / TITLE:  - Role of radiotherapy in local control of non-AIDS associated Kaposi’s sarcoma patients in Korea: a single institution experience.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Radiat Oncol J. 2012 Dec;30(4):153-7. doi: 10.3857/roj.2012.30.4.153. Epub 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 3857/roj.2012.30.4.153

AUTORES / AUTHORS:  - Chang JH; Kim IH

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Seoul National University College of Medicine,  Seoul, Korea.

RESUMEN / SUMMARY:  - PURPOSE: There has been no definite consensus on standard treatment, either local or systemic, for the Kaposi’s sarcoma (KS). Radiotherapy (RT) can be a good local therapeutic choice especially in non-AIDS associated KS (NAKS) for its indolent behavior. MATERIALS AND METHODS: Medical records of 17 KS patients treated with RT at the Seoul National University Hospital from February 1998 to January 2012 were retrospectively reviewed. One human immunodeficiency virus (HIV)+ patient with 3 lesions was excluded. The total number of the lesion was 23 among the 16 patients. The median follow-up period was 27.9 months. Correlation between response and variables was analyzed using the logistic regression model. Median age of the patients was 75 years. All the 23 lesions were located at the extremities. Fourteen (61%) of those had pain or local swelling as the initial presentation. Ten patients had possible causes of immunodeficiency and were regarded as iatrogenic, and other 6 were classic KS. Median dose of RT was 36 Gy. RESULTS: No KS-related death was observed. Excluding 2 with short-term follow-up  only, complete response and partial response were obtained in 2 (9%) and 19 (73%) lesions, respectively. Of those, 3 lesions underwent local progression. Six had out-of-field recurrence after RT. Symptom improvement was achieved in 13 (93%) of 14 patients. Grade 2 skin toxicities were found in 9 lesions but all got improvement after treatment. When divided into responsive and progressive group,  free from progression was not related to any of the possible variables. CONCLUSION: RT is effective in local control of NAKS resulting great response rate.

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[448]

TÍTULO / TITLE:  - Expression of p53 and p21(WAF-1), apoptosis, and proliferation of smooth muscle cells in normal myometrium during the menstrual cycle: implication of DNA damage  and repair for leiomyoma development.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Mol Morphol. 2012 Dec;45(4):214-21. doi: 10.1007/s00795-011-0562-3. Epub 2012 Dec 7.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00795-011-0562-3

AUTORES / AUTHORS:  - Suzuki A; Kariya M; Matsumura N; Baba T; Yagi H; Mandai M; Konishi I; Fujii S

INSTITUCIÓN / INSTITUTION:  - Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Kyoto 606-8507, Japan. flapper@kuhp.kyoto-u.ac.jp

RESUMEN / SUMMARY:  - Uterine leiomyoma is the most common tumor in the female genital tract, although  its pathogenesis remains unclear. Molecular analyses have demonstrated that each  leiomyoma nodule is monoclonal and harbors various DNA abnormalities, suggesting  that DNA damage in normal smooth muscle cells plays an important role in the pathogenesis of leiomyoma. The aim of this study is to evaluate precisely when and where DNA damage occurs in the myometrium. The localization of damaged, apoptotic, and proliferating cells was evaluated by immunohistochemical staining  of p53, p21(WAF-1), TUNEL, and the cell proliferation marker, Ki-67, in normal myometrium during the menstrual cycle. p53-positive cells and p21(WAF-1)-positive cells were observed during the follicular phase, mostly in the submucosal layer of the myometrium. TUNEL-positive cells were sporadically identified in this layer during either the menstrual or follicular phase. In contrast, the number of Ki-67-positive cells was higher in the luteal phase. These results suggest that DNA damage, repair, and apoptosis occur cyclically in normal myometrium during the follicular phase. In addition, smooth muscle cells proliferate in the luteal  phase, which may be a vulnerable period for DNA damage. Thus, these cyclic events during the menstrual cycle may contribute to a high incidence of leiomyoma development.

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[449]

TÍTULO / TITLE:  - Kaposi’s sarcoma in a steroid-treated antisynthethase antibody syndrome patient.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Reumatol Clin. 2012 Dec 25. pii: S1699-258X(12)00214-8. doi: 10.1016/j.reuma.2012.07.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.reuma.2012.07.002

AUTORES / AUTHORS:  - Bragado L; Ruiz Gutierrez L; Cuende E; Lopez Gonzalez JL

INSTITUCIÓN / INSTITUTION:  - Servicio de Medicina Interna, Hospital Universitario Principe de Asturias, Alcala de Henares, Madrid, España.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma (KS) is a malignant vascular tumor widely known as a complication of acquired immunodeficiency syndrome (AIDS) but also related to immunosupression in renal transplants, and less frequently, to other diseases. We describe a case of KS in a patient affected by anti-synthetase syndrome treated with steroids.

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[450]

TÍTULO / TITLE:  - Extensive adipocytic maturation can be seen in myxoid liposarcomas treated with neoadjuvant doxorubicin and ifosfamide and pre-operative radiation therapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Sarcoma Res. 2012 Dec 29;2(1):25.

            ●● Enlace al texto completo (gratuito o de pago) 1186/2045-3329-2-25

AUTORES / AUTHORS:  - Wang WL; Katz D; Araujo DM; Ravi V; Ludwig JA; Trent JC; Patel SR; Lin PP; Guadagnolo A; Lopez-Terrada D; Dei Tos AP; Lewis VO; Lev D; Pollock RE; Zagars GK; Benjamin RS; Madewell JE; Lazar AJ

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: Trabectedin and thioglitazones have been documented to induce adipocytic maturation in myxoid liposarcoma; we have noted this in our experience as well. Intriguingly, we have also encountered this same phenomenon in myxoid liposarcomas exposed to various combinations of neoadjuvant doxorubicin and ifosfamide systemic chemotherapy with preoperative radiation, where the pathological effects have been less characterized. We examined the histological changes, including adipocytic maturation, associated with this treatment in patients with myxoid liposarcoma and evaluated for prognostic significance. METHODS: Twenty-two patients were identified with histologically confirmed myxoid liposarcomas (9 with variable hypercellular areas) who were treated with neoadjuvant doxorubicin (75-90 mg/m2/continous infusion over 72h every 3 week) and ifosfamide (2.5 g/m2 daily x 4 every 3 weeks) for 4-6 cycles. Twenty-one patients received pre-operative radiation including 5 with concurrent gemcitabine. Pre- and post-treatment MRI studies were compared for changes in tumor area, fat content and contrast uptake, with the latter two estimated as: none, <25%, 25-49% and >50%. Post-treatment specimens were evaluated for hyalinization, necrosis and adipocytic maturation. Clinical follow-up was obtained. RESULTS: Median age was 45 (26-72) years with a median tumor size of 11 (2-18) cm. All occurred in the lower extremities except for one case in the neck. As is common in myxoid liposarcoma, all had extensive treatment changes (>90%) with extensive hyalinization (n = 16; >90%) or prominent adipocytic maturation (n = 6; >50%) including 2 cases composed almost entirely of mature-appearing adipose tissue. Variable necrosis was identified (5-30%). MRI revealed a decrease in tumor area in all but one tumor (median, 65%), an increase in fat content in 7 tumors (n = 2, >50%;n = 2, 25-50%;n = 3,<25%), and a decrease in contrast enhancement in most tumors (n = 5, >50%; n = 9, 25-49%; n = 7, <25%). Median follow-up was 57 (12-96) months with 17 alive with no disease/metastases, 3 alive with disease and 2 dead of disease. Six patients developed metastases with median interval of 26 (22-51) months post resection. Four of 6 tumors with increased adipocytic maturation >50% on histology had increased fat detected by MRI (>25%). All 6 are alive but 2 developed metastases. In the remaining patients, 4 developed metastases with 14 alive and 2 dead of disease. CONCLUSION: Myxoid liposarcoma exposed to neoadjuvant doxorubicin and ifosfamide and pre-operative radiation can have prominent adipocytic maturation similar to trabectedin treatment. Myxoid liposarcomas exhibit extensive treatment changes with prominent hyalinization being the most common histological change. Despite this, patients develop metastases regardless of adipocytic maturation. While of unclear significance, no patient with fatty maturation died of disease.

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[451]

TÍTULO / TITLE:  - Management of Intraneural Fibro-Lipoma of the Median Nerve and the Role of Pressure-Specified Sensory Device (PSSD) for the Patient’s Motor and Sensorial Evaluations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Turk Neurosurg. 2013;23(1):31-7. doi: 10.5137/1019-5149.JTN.6106-12.0.

            ●● Enlace al texto completo (gratuito o de pago) 5137/1019-5149.JTN.6106-12.0

AUTORES / AUTHORS:  - Sever C; Sahin C; Bayram Y; Kapi E; Kulahci Y; Berber U; Incedayi M; Uygur F

INSTITUCIÓN / INSTITUTION:  - Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of Plastic and Reconstructive Surgery and Burn Unit, Istanbul, Turkey.

RESUMEN / SUMMARY:  - AIM: The intraneural fibro-lipoma is a benign, uncommon tumor which is characterised with infiltration of the epineurium and perineurium by fibrofatty tissue. The preoperative diagnosis is difficult. However, the Pressure-Specified  Sensory Device (PSSD) may support identifying the earliest stages of intraneural  fibro-lipoma when traditional electrodiagnostic testing will not be able to detect a change in peripheral nerve function. MATERIAL and METHODS: Five patients (3 male, 2 female, age 23-53; mean 41 years) with intraneural fibro-lipoma were operated on. Grip strength, pinch strength and sensorial functions were assessed  in all patients before surgery and at the end of the follow-up period by PSSD. RESULTS: The patients were followed-up for 7 to 24 months (mean; 12 month). All patient’s condition improved dramatically following the operation and all patients had total relief of pain and paresthesia. CONCLUSION: The decompression  of intraneural fibro-lipoma of the nerve with limited excision and epineurotomy without sacrificing the main nerve and its branches is the ideal surgical procedure. We recommend the use of PSSD in the investigation of patients with peripheral nerve compression, and chronic unusual volar forearm and wrist swelling. PSSD is an important tool for pre-operative evaluation and diagnosis of intraneural fibro-lipoma.

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[452]

TÍTULO / TITLE:  - Sarcoma-like pyogenic granuloma of the thumb and respiratory restrictive syndrome in a non-compliant hemodialysis patient.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Nephrol Urol. 2012 Jul;2(2):152-7. doi: 10.1159/000345281. Epub 2012 Nov 8.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000345281

AUTORES / AUTHORS:  - Simon I; Gevenois PA; Del Marmol V; El Kazzi W; Trepant AL; Gastaldello K; Nortier JL

INSTITUCIÓN / INSTITUTION:  - Department of Nephrology, Universite Libre de Bruxelles, Brussels, Belgium.

RESUMEN / SUMMARY:  - Pyogenic granuloma is a benign vascular tumor of the skin or mucosae usually observed after irritative processes. We report the case of a non-compliant hemodialysis patient with severe hyperparathyroidism who rapidly developed growing pyogenic granuloma of the distal part of the left thumb. This tumor mimicked sarcoma and caused recurrent bleeding during hemodialysis sessions. Hand radiograph revealed an osteolytic lesion compatible with a brown tumor. Among other brown tumors, several of those found in the ribs were responsible of a severe respiratory restrictive deficit. This report highlights the difficulty to  choose the adequate treatment of severe hyperparathyroidism, and discusses the benefit/risk balance of performing parathyroidectomy.

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[453]

TÍTULO / TITLE:  - Fibroma of tendon sheath of the hand: a series of 20 patients with 23 tumours.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Hand Surg Eur Vol. 2012 Dec 4.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1753193412469146

AUTORES / AUTHORS:  - Al-Qattan MM

INSTITUCIÓN / INSTITUTION:  - Division of Plastic and Hand Surgery, King Saud University, Riyadh, Saudi Arabia.

RESUMEN / SUMMARY:  - Fibroma of tendon sheath is an uncommon fibrous tumour that has a predilection for the hand. Large series from Histopathological Units report a local recurrence rate of 24% after surgical excision. In the hand/orthopaedic surgery literature,  fibroma of tendon sheath was generally reported as isolated case reports with unusual presentations, such as triggering and carpal tunnel syndrome. The current article reports on a series of 23 tumours of the hands of 20 patients. These were all adults (mean age of 36 years) with a male to female ratio of 3:1. The thumb and index were the most common sites. A slow-growing painless mass was the clinical presentation in every case. Total surgical excision was ensured by excision of part of flexor sheath/palmar fascia to which the tumour was attached. Diagnosis was confirmed by the classic histological features of fibroma of tendon sheath. There were no recurrences at final follow-up 2-5 years after surgery.

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[454]

TÍTULO / TITLE:  - Paraneoplastic pemphigus with anti-laminin-332 autoantibodies in a patient with follicular dendritic cell sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JAMA. Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://jama.ama-assn.org/search.dtl 

            ●● Cita: JAMA: <> Dermatol. 2013 Jan 1;149(1):111-3. doi: 10.1001/2013.jamadermatol.512.

            ●● Enlace al texto completo (gratuito o de pago) 1001/2013.jamadermatol.512

AUTORES / AUTHORS:  - Sugiura K; Koga H; Ishikawa R; Matsumoto T; Matsubara M; Hagiwara R; Muro Y; Hashimoto T; Akiyama M

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[455]

TÍTULO / TITLE:  - The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Sarcoma Res. 2012 Dec 18;2(1):24. doi: 10.1186/2045-3329-2-24.

            ●● Enlace al texto completo (gratuito o de pago) 1186/2045-3329-2-24

AUTORES / AUTHORS:  - Berghuis D; Schilham MW; Santos SJ; Savola S; Knowles HJ; Dirksen U; Schaefer KL; Vakkila J; Hogendoorn PC; Lankester AC

INSTITUCIÓN / INSTITUTION:  - Department of Pediatrics, Leiden University Medical Center, Albinusdreef 2, 2300, RC, Leiden, the Netherlands. a.lankester@lumc.nl.

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: Chemokine receptor CXCR4, together with its ligand CXCL12,  plays critical roles in cancer progression, including growth, metastasis and angiogenesis. Ewing sarcoma is a sarcoma with poor prognosis despite current therapies, particularly for patients with advanced-stage disease. Lungs and bone  (marrow), organs of predilection for (primary/metastatic) Ewing sarcoma, represent predominant CXCL12 sources. METHODS: To gain insight into the role of the CXCR4-CXCL12 axis in Ewing sarcoma, CXCR4, CXCL12 and hypoxia-inducible factor-1alpha protein expression was studied in therapy-naive and metastatic tumors by immunohistochemistry. CXCR4 function was assessed in vitro, by flow cytometry and proliferation/ cell viability assays, in the presence of recombinant CXCL12 and/or CXCR4-antagonist AMD3100 or under hypoxic conditions. RESULTS: Whereas CXCR4 was predominantly expressed by tumor cells, CXCL12 was observed in both tumor and stromal areas. Survival analysis revealed an (expression level-dependent) negative impact of CXCR4 expression (p < 0.04). A role for the CXCR4-CXCL12 axis in Ewing sarcoma growth was suggested by our observations that i) CXCR4 expression correlated positively with tumor volume at  diagnosis (p = 0.013), ii) CXCL12 was present within the microenvironment of virtually all cases, iii) CXCL12 induced proliferation of CXCR4-positive Ewing sarcoma cell lines, which could be abrogated by AMD3100. CXCR4 expression was not correlated with occurrence of metastatic disease. Also, therapy-naive tumors demonstrated higher CXCR4 expression as compared to metastases (p = 0.027). Evaluation of in vivo hypoxia-inducible factor-1alpha expression and culture of cells under hypoxic conditions revealed no role for hypoxia in CXCR4 expression.  CONCLUSIONS: Together, our results imply a crucial role for the CXCR4-CXCL12 axis in auto- and/or paracrine growth stimulation. Integration of CXCR4-targeting strategies into first- and/or second-line treatment regimens may represent a promising treatment option for Ewing sarcoma.

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[456]

TÍTULO / TITLE:  - Soft tissues sarcomas of the head and neck in adult: histo-clinical analysis of 30-years material in the data of ENT Department of Silesian Medical University.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Otolaryngol Pol. 2012 Nov-Dec;66(6):382-6. doi: 10.1016/j.otpol.2012.06.028. Epub 2012 Jul 6.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.otpol.2012.06.028

AUTORES / AUTHORS:  - Markowski J; Dziubdziela W; Podlejska K; Likus W; Pasternak K; Kajor M; Witkowska M; Gierek T; Paluch J

INSTITUCIÓN / INSTITUTION:  - Katedra i Klinika Laryngologii SUM w Katowicach, Poland. jmarkow1@poczta.onet.pl

RESUMEN / SUMMARY:  - AIM: The aim of this study was the assessment of efficiency treatment of soft tissues sarcomas in adult in the data of ENT Department of Silesian Medical University in Katowice. MATERIAL AND METHODS: Retrospective analysis has been carried out for 22 patients with the diagnosis of STS in head and neck, treated in the ENT Department of the Silesian Medical University in Katowice, Poland, in  the years 1980-2010. Most common histopathological diagnosis was fibrosarcoma. Preferred treatment was surgery combined with radiotherapy. Despite intensive treatment results remain unsatisfactory. RESULTS: The most frequent cause of treatment failure was local recurrence, which was found in 7 cases. In 2 patients, nodal recurrence occurred, while in further 4 patients dissemination of neoplasm occurred. Of the 22 patients in our study, 13 died. Complete 5-year survival in the study group was achieved in case of 3 patients, 4 other patients  have survived up to 3 years so far, while 1 patient survived less than 1 year so  far. CONCLUSIONS: The application of surgical treatment combined with post-surgical radiotherapy allowed to enhance life quality and to prolong the life of patients. Unfortunately, the percentage of local recurrence cases still remains high. Results of STS treatment are still not satisfactory. The main reasons for it include late for treatment, in relation to the moment of noticing  the tumor, in the majority of cases a high malignancy level, as well as technically difficult procedures, along with the strong tendency for local recurrence.

 

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[457]

TÍTULO / TITLE:  - Shared cell surface marker expression in mesenchymal stem cells and adult sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Stem Cells. Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://stemcells.alphamedpress.org/ 

            ●● Cita: Stem Cells: <> Transl Med. 2013 Jan;2(1):53-60. doi: 10.5966/sctm.2012-0055. Epub 2012 Dec 19.

            ●● Enlace al texto completo (gratuito o de pago) 5966/sctm.2012-0055

AUTORES / AUTHORS:  - Wirths S; Malenke E; Kluba T; Rieger S; Muller MR; Schleicher S; Hann von Weyhern C; Nagl F; Fend F; Vogel W; Mayer F; Kanz L; Buhring HJ; Kopp HG

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, South West German Comprehensive Cancer Center, Tuebingen, Germany.

RESUMEN / SUMMARY:  - Advanced adult soft-tissue sarcomas (STSs) are rare tumors with a dismal prognosis and limited systemic treatment options. STSs may originate from mesenchymal stem cells (MSCs); the latter have mainly been isolated from adult bone marrow as plastic-adherent cells with differentiation capacity into mesenchymal tissues. Recently, a panel of antibodies has been established that allows for the prospective isolation of primary MSCs with high selectivity. Similar to cancer stem cells in other malignancies, sarcoma stem cells may bear immunophenotypic similarity with the corresponding precursor, that is, MSCs. We therefore set out to establish the expression pattern of MSC markers in sarcoma cell lines and primary tumor samples by flow cytometry. In addition, fibroblasts  from different sources were examined. The results document a significant amount of MSC markers shared by sarcoma cells. The expression pattern includes uniformly expressed markers, as well as MSC markers that only stained subpopulations of sarcoma cells. Expression of W5C5, W8B2 (tissue nonspecific alkaline phosphatase  [TNAP]), CD344 (frizzled-4), and CD271 marked subpopulations displaying increased proliferation potential. Moreover, CD271+ cells displayed in vitro doxorubicin resistance and an increased capacity to form spheres under serum-free conditions. Interestingly, another set of antigens, including the bona fide progenitor cell markers CD117 and CD133, were not expressed. Comparative expression patterns of novel MSC markers in sarcoma cells, as well as fibroblasts and MSCs, are presented. Our data suggest a hierarchical cytoarchitecture of the most common adult type sarcomas and introduce W5C5, TNAP, CD344, and CD271 as potential sarcoma progenitor cell markers.

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[458]

TÍTULO / TITLE:  - Familial leiomyomatosis cutis affecting nine family members in two successive generations including four cases of Reed’s syndrome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Dermatol Venereol Leprol. 2013 Jan;79(1):83-7. doi: 10.4103/0378-6323.104674.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0378-6323.104674

AUTORES / AUTHORS:  - Mandal RK; Koley S; Banerjee S; Kabiraj SP; Ghosh SK; Kumar P

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, Venereology, and Leprosy, North Bengal Medical College, Darjeeling, West Bengal, India.

RESUMEN / SUMMARY:  - Reed’s syndrome or familial leiomyomatosis cutis et uteri is an autosomal dominant disorder, characterized by multiple cutaneous and uterine leiomyomas. We report here a case of a 53-year-old woman who presented to us with multiple painful nodules over different parts of her body. Based on the histopathological  examination, imaging, and past medical records, a diagnosis of Reed’s syndrome was made. Three of her sisters had similar disease. Subsequently, it was found that a total of nine members of their family in two successive generations were affected with cutaneous leiomyomas. The present case series has been reported for its interesting clinical presentations and rarity.

 

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[459]

TÍTULO / TITLE:  - Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: clinicoimmunohistochemical and histogenetic characteristics.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Folia Histochem Cytobiol. 2012;50(4):513-8. doi: 10.5603/19688.

            ●● Enlace al texto completo (gratuito o de pago) 5603/19688

AUTORES / AUTHORS:  - Kedzia W; Pruski D; Iwaniec K; Przybylski M; Friebe Z; Rajpert-Kedzia H

INSTITUCIÓN / INSTITUTION:  - Department of Gynecology I, Karol Marcinkowski University of Medical Sciences, Poznan Laboratory of Cervical Pathophysiology, Gynecology and Obstetrics Clinical Hospital, Karol Marcinkowski University of Medical Sciences, Poznan. pruski@oxytop.pl.

RESUMEN / SUMMARY:  - Aims: To search for favorable prognostic factors in CS on the basis of clinical,  morphological and immunocytochemical data, while simultaneously considering histogenesis of this neoplasm. Methods and Results: Thirty two uterine CS patients were analyzed based on clinical and morphological data. In addition, each specimen was immunohistochemically stained with appropriately selected antibodies characterizing relevant types of cells and tissues. The presence of both carcinomatous and sarcomatous patterns was observed in all tumors. Among carcinomatous patterns, endometrioid carcinoma was most common, while serous, clear cell, and undifferentiated were less common. Among sarcomatous patterns, endometrioid sarcomas represented the largest group, while leiomyosarcomas, chondrosarcomas, fibrosarcomas, osteosarcomas, rhabdosarcomas were rarely observed. Mitotic activity was evidently higher in carcinomas. Among seven neoplasms the expression of both cytokeratin and vimentin was noted in cells of carcinomatous patterns. Conclusions: This study shows that an early diagnosis (stage I-II) and an initial aggressive surgical cytoreduction are favorable prognostic factors in CS. Furthermore, cytokeratin-vimentin positive cells in carcinomatous patterns suggest sarcomatous metaplasia of adenocarcinoma. Unfortunately, the study did not identify histological structures of prognostic value.

 

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[460]

TÍTULO / TITLE:  - Clinicopathological study of 113 gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Gastroenterol. 2012 Dec 8.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12664-012-0273-2

AUTORES / AUTHORS:  - Bhalgami R; Manish K; Patil P; Mehta S; Mohandas KM

INSTITUCIÓN / INSTITUTION:  - Tata Memorial Hospital, Parel, Mumbai, 400 012, India, rahul_bhalgami@hotmail.com.

RESUMEN / SUMMARY:  - BACKGROUND: Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract. A retrospective study was done to evaluate the clinical and pathological features and the effect of adjuvant treatment with imatinib. METHOD: The case records of 113 GIST patients were retrospectively reviewed and the clinicopathological features, treatments, and outcomes were recorded. RESULTS: There were 82 males and 31 females, with a median age of 51 years. All patients were symptomatic (mean duration 4 months) and abdominal pain  was the most common symptom. The primary sites of GIST were small intestine (38), stomach (36), and others (39). The tumor diameter on imaging varied from 1 to 26  (mean 10.9) cm. Thirty percent of patients presented with metastasis. There was no association between tumor size and presence of metastasis (p = 0.9). Most common histology was spindle cell morphology followed by mixed spindle cell and epithelioid morphology. Seventy percent patients had high risk (HR) category as per Fletcher risk score. Fifty-three percent had curative resection, after which  34 % had adjuvant imatinib therapy. Recurrence rates were significantly lower in  patients receiving adjuvant imatinib therapy (p = 0.003). No statistically significant association was noted between HR Fletcher score, Mib score >10, tumor size >10 cm, and the risk of recurrence (p = 0.29, 0.07, and 0.87, respectively). Liver was the most common site of metastasis. Side effects were tolerable and edema and fluid retention were the commonest. CONCLUSION: Sites of GIST in Indian patients were different from those in western studies. Adjuvant imatinib therapy  significantly reduced the risk of recurrence.

 

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[461]

TÍTULO / TITLE:  - Treatment for Uterine Fibroids: Searching for Effective Drug Therapies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Drug Discov Today Ther Strateg. 2012;9(1):e41-e49.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ddstr.2012.06.001

AUTORES / AUTHORS:  - Taylor DK; Leppert PC

INSTITUCIÓN / INSTITUTION:  - Department of Chemistry, North Carolina Central University, 3105 M. Townes Science Building, 1801 Concord Street, Durham, NC 27707, United States ; Departments of Obstetrics and Gynecology and Pathology, Duke University School of Medicine, 242 Sands Building, Box 103206, Durham, NC 27710, United States.

RESUMEN / SUMMARY:  - Uterine fibroids are common reproductive-age benign tumors that contribute to severe morbidity and infertility. Cumulative incidence is 4 times higher in Africian-Americans compared to Caucasians and constitutes a major health disparity challenge. Fibroids are the leading indication for hysterectomy and their management averages $21 billion annually in the US. No long term minimally  invasive therapies exist. Thus, promising drug therapies, their chemistry, pharmacology, and clinical efficacy, focusing first on innovative drug delivery approaches, are reviewed.

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[462]

TÍTULO / TITLE:  - Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children’s Oncology Group (COG) study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Mol Epidemiol Genet. 2012;3(4):286-93. Epub 2012 Nov 15.

AUTORES / AUTHORS:  - Musselman JR; Bergemann TL; Ross JA; Sklar C; Silverstein KA; Langer EK; Savage SA; Nagarajan R; Krailo M; Malkin D; Spector LG

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Epidemiology and Clinical Research, University of Minnesota Minneapolis MN 55455.

RESUMEN / SUMMARY:  - Osteosarcoma (OS) is a rare malignant bone tumor with an overall incidence rate of 4.6 cases per million children aged 0-19 years in the United States. While the etiology of OS is largely unknown, its distinctive age-incidence pattern suggests that growth and development is crucial in genesis. Prior studies have suggested that variants in genes in the estrogen metabolism (ESTR) and insulin-like growth  factor/growth hormone (IGF/GH) pathways are associated with OS. We examined 798 single nucleotide polymorphisms (SNPs) in 42 genes from these pathways in a case-parent study (229 complete triads and 56 dyads) using buccal cell samples. Relative risks (RR) and 95% confidence intervals (CI) associated with transmitting one or two copies of the variant were estimated using log-linear models. After Bonferroni correction, 1 SNP within the ESTR pathway (rs1415270: RR = 0.50 and 8.37 for 1 and 2 vs. 0 copies, respectively; p = 0.010), and two SNPs  in the IGF/GH pathway (rs1003737: RR = 0.91 and 0.0001 for 1 and 2 vs. 0 copies,  respectively; p <0.0001 and rs2575352: RR = 2.62 and 0.22 for 1 and 2 vs. 0 copies; p < 0.0001) were significantly associated with OS incidence. These results confirm previous findings that variation in the estrogen metabolism and bone growth pathways influence OS risk and further support a biologically and epidemiologically plausible role in OS development.

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[463]

TÍTULO / TITLE:  - Genetic studies in a coexistence of acromegaly, pheochromocytoma, gastrointestinal stromal tumor (GIST) and thyroid follicular adenoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arq Bras Endocrinol Metabol. 2012 Nov;56(8):507-12.

AUTORES / AUTHORS:  - Boguszewski CL; Fighera TM; Bornschein A; Marques FM; Denes J; Rattenbery E; Maher ER; Stals K; Ellard S; Korbonits M

INSTITUCIÓN / INSTITUTION:  - Endocrine Division, Department of Internal Medicine, University Hospital at Universidade Federal do Parana, Curitiba, Brazil.

RESUMEN / SUMMARY:  - We report on an adult woman with rare coexistence of acromegaly, pheochromocytoma (PHEO), gastrointestinal stromal tumor (GIST), intestinal polyposis, and thyroid  follicular adenoma. At the age of 56, she was diagnosed with acromegaly caused by a pituitary macroadenoma, treated by transsphenoidal surgery, radiotherapy, and octreotide. During routine colonoscopy, multiple polyps were identified as tubular adenomas with high-grade dysplasia on histology. Years later, an abdominal mass of 8.0 x 6.2 cm was detected by routine ultrasound. Surgical exploration revealed an adrenal mass and another tumor adhered to the lesser gastric curvature, which were removed. Pathology confirmed the diagnosis of PHEO  and GIST. PHEO immunohistochemistry was negative for GHRH. During follow-up, nodular goiter was found with normal levels of calcitonin and inconclusive cytology. Near-total thyroidectomy was performed, revealing a follicular adenoma. Her family history was negative for all of these tumor types. Genetic analysis for PHEO/paraganglioma genes (SDH A-D, SDHAF2, RET, VHL, TMEM127, and MAX), and pituitary-related genes (AIP, MEN1, and p27) were negative. Though the finding of PHEO and acromegaly with multiple other tumors could be a fortuitous coexistence, we suggest that this case may represent a new variant of MEN syndrome with a de novo germline mutation in a not yet identified gene. Arq Bras Endocrinol Metab. 2012;56(8):507-12.

 

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[464]

TÍTULO / TITLE:  - Intradural chordoma mimicking a lateral sphenoid wing meningioma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Folia Neuropathol. 2012;50(4):407-12.

AUTORES / AUTHORS:  - Kunert P; Dziedzic T; Matyja E; Marchel A

INSTITUCIÓN / INSTITUTION:  - Przemyslaw Kunert, MD, PhD, Department of Neurosurgery, Medical University ofWarsaw, Banacha street 1a, 02-097 Warsaw, Poland, phone: +48 22 599 25 75, fax: +48 22 658 36 53, e-mail: pkunert@wp.pl.

RESUMEN / SUMMARY:  - Chordomas are rare tumours arising from notochordal remnants. Classical chordomas are generally extradural and, despite benign histopathology, they typically destroy the clivus and surrounding bone structures. Intradural lesions are extremely rare and less than thirty cases of intracranial, exclusively intradural chordomas have been reported so far. The intracranial, intradural but extranotochordal location of chordoma is extremely unique. The authors present a  case of chordoma in intracranial location that clinically mimics lateral sphenoid wing meningioma. A previously healthy 39-year-old man was admitted to our Department because of optic disc oedema without neurological deficits. Neuroimaging studies showed a large, contrast-enhanced tumour in the right frontotemporal region that was thought to be a pterional meningioma. The patient  underwent successful removal of the tumour. Histopathological study revealed a typical pattern of chordoma, confirmed by immunohistochemical findings. Because of the tumour location the differentiation between chordoma and chordoid meningioma ought to be considered. Such cases, including the present one, may lead to the conclusion that embryonic notochordal remnants may be lost in different places, even away from the neuroaxis.

 

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[465]

TÍTULO / TITLE:  - Restrictive orbital myofibroblastic sarcoma in a cat - Cross-sectional imaging (MRI & CT) appearance, treatment, and outcome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Vet Ophthalmol. 2013 Jan 3. doi: 10.1111/vop.12016.

            ●● Enlace al texto completo (gratuito o de pago) 1111/vop.12016

AUTORES / AUTHORS:  - Thomasy SM; Cissell DD; Arzi B; Vilches-Moure JG; Lo WY; Wisner ER; Dubielzig RR; Maggs DJ

INSTITUCIÓN / INSTITUTION:  - Veterinary Medical Teaching Hospital School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.

RESUMEN / SUMMARY:  - A 16-year-old spayed female cat was evaluated for lagophthalmos and chronic exposure keratitis in both eyes. Ophthalmic examination revealed upper and lower  eyelid entropion of the left eye (OS) and markedly decreased retropulsion, restricted eye movement, marked episcleral congestion, and severe keratitis of both eyes (OU). Magnetic resonance imaging of both orbits revealed extensive, irregular, contrast-enhancing tissue without evidence of osteolysis considered compatible with diffuse inflammatory tissue. Feline herpesvirus DNA was not detected in conjunctival samples. Partial temporary tarsorrhaphies were placed OU, and the cat was treated with topically administered erythromycin ointment OU, orally administered famciclovir and prednisolone, and sublingually administered buprenorphine. Little improvement was noted after 2 weeks. Six weeks after initial presentation, a left exenteration was performed and histopathology was consistent with idiopathic sclerosing orbital pseudotumor (ISOP). Ten weeks after initial presentation, the patient represented for weight loss and jaw pain. Computed tomography demonstrated disease progression in the right orbit and the patient was euthanized. Histopathology of the decalcified skull revealed an aggressive and highly infiltrative mass involving the right orbit with extension  to the maxilla, hard palate, nasal cavity and gingiva most consistent with feline restrictive orbital myofibroblastic sarcoma (FROMS). Clinical data from this patient support the reclassification of ISOP as FROMS. MRI and CT may provide supportive evidence for FROMS, but histopathology is necessary for definitive diagnosis. Aggressive and early surgical treatment, including bilateral exenteration, with adjunctive radiotherapy and/or chemotherapy should be considered for patients with FROMS.

 

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[466]

TÍTULO / TITLE:  - Gigantism Treated by Pure Endoscopic Endonasal Approach in a Case of McCune-Albright Syndrome with Sphenoid Fibrous Dysplasia: A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurol Surg A Cent Eur Neurosurg. 2013 Jan 10.

            ●● Enlace al texto completo (gratuito o de pago) 1055/s-0032-1330957

AUTORES / AUTHORS:  - Sharifi G; Jalessi M; Sarvghadi F; Farhadi M

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Loghman Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.

RESUMEN / SUMMARY:  - McCune-Albright syndrome (MAS) is an uncommon polyostotic manifestation of fibrous dysplasia in association with at least one endocrinopathy that is mostly  associated with precocious puberty and hyperpigmented skin macules named cafe-au-lait spots. We present an atypical manifestation of McCune-Albright syndrome in a 19-year-old man with the uncommon association of polyostotic fibrous dysplasia and gigantism in the absence of cafe-au-lait spots and precocious puberty. He presented with a height increase to 202 cm in the previous 3 years, which had become more progressive in the few months prior. Physical examination revealed only a mild facial asymmetry; however, a computed tomography (CT) scan discovered vast areas of voluminous bones with ground-glass density and thickening involving the craniofacial bones and skull base. Magnetic resonance imaging (MRI) found a right stalk shift of the pituitary with a 20 mm pituitary adenoma. We describe the diagnostic and endoscopic endonasal transsphenoidal approach for excision of the tumor.

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[467]

TÍTULO / TITLE:  - A case of multiple metastatic giant rectal GIST successfully treated with surgical intervention after administration of imatinib mesylate.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nihon Shokakibyo Gakkai Zasshi. 2013;110(1):74-80.

AUTORES / AUTHORS:  - Kitamura D; Ikeda K; Unotoro J; Seki E; Gonda H; Izumi H

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Ota General Hospital.

RESUMEN / SUMMARY:  - A 69-year-old man was admitted with difficulty in defecation and urination. CT showed a giant tumor connected with the rectum in the lower pelvic cavity, and also the presence of 4 smooth surfaced tumors, 3 of which were in the abdominal cavity, while the other one was in the left inguinal region. A core needle biopsy was performed in the left inguinal region indicated the presence of gastrointestinal stromal tumor (GIST), and we clinically diagnosed this case as having multiple metastatic rectal GISTs. The patient was treated with imatinib mesylate, and CT showed the size of the rectal GIST to have dramatically decreased, with only one metastatic tumor remaining in the abdominal cavity. Therefore, an abdominoperineal resection and metastasectomy were performed, and the tumors were completely excised. The patient is alive without recurrence at 18 months after surgery, while continuing to receive imatinib mesylate.

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[468]

TÍTULO / TITLE:  - Early detection and gemcitabine/cisplatin combination positively effect survival  in sarcomatoid carcinoma of the urinary bladder.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asian Pac J Cancer Prev. 2012;13(11):5729-33.

AUTORES / AUTHORS:  - Baseskioglu B; Duman BB; Kara IO; Can C; Yildirim M; Acikalin M

INSTITUCIÓN / INSTITUTION:  - Department of Urology, ESOGU Medical Faculty, Turkey E-mail : berboz@hotmail.com.

RESUMEN / SUMMARY:  - Background and Objectives: This study aimed to present the clinicopathological characteristics and treatment of patients with bladder carcinoma with sarcomatoid differentiation at our institution. Methods: Between 1995- 2009, 950 patients were followed-up for bladder carcinoma. Among them, 14 patients with sarcomatoid  carcinoma were retrospectively reviewed, and their clinical, pathological features and treatment were recorded. Results: Median age of the patients was 65  years (range: 41-86 years), 12 (86%) being male and 2 (14%) female. All the patients presented with hematuria and 11 (88%) had a history of smoking. The tumor growth pattern was solid in 10 patients, papillary in 2, and mixed in 2. In all, 5 of the patients had urothelial carcinoma with sarcomatoid differentiation  and 9 were diagnosed with sarcomatoid carcinoma. Five patients underwent radical  cystectomy with ileal conduit surgery, 2 patients refused cystectomy, and 8 patients underwent re-TUR. Following diagnosis ,12 of the patients died in mean 10.7 months (range: 1-48 months). Conclusion: Urothelial carcinomas with sarcomatoid features are aggressive and are usually at advanced stage at the time of diagnosis. The outcomes of multimodal treatment are not satisfactory. Significant findings of the present study are that early diagnosis positively affect survival and that gemcitabine and cisplatin in combination can positively  affect survival.

 

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[469]

TÍTULO / TITLE:  - Refer prior to biopsy of suspected appendicular soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - N Z Med J. 2012 Nov 23;125(1366):12-9.

AUTORES / AUTHORS:  - Elliott RS; Flint M; French G

INSTITUCIÓN / INSTITUTION:  - Nelson Public Hospital, Waimea Road, Nelson, New Zealand. Robert.S.J.Elliott@gmail.com.

RESUMEN / SUMMARY:  - AIM: Appendicular soft tissue tumours are rare and inappropriate investigation can result in unnecessary loss of limb or life. We reviewed the investigation and referrals of patients to our institution. METHOD: This is a review of prospectively collected data stored in a tumour registry database. We included all patients (126) referred to the service for investigation and management with  a primary soft tissue tumour in 2006 and 2007. RESULTS: There was a highly significant association (RR=6.2) between pre referral procedures (PRPs) and suffering a complication (P<0.0001) in comparison to non-biopsied referrals (NBRs). Those referred by general surgeons were more likely (RR=2.6) to have undergone PRP (p<0.0017). The median interval between referral and senior author  review was 8 days for the PRP group and 10 days for the NBR group (P=0.2574). CONCLUSION: Biopsy of suspected appendicular soft tissue sarcoma should be performed by a tumour specialist or in prior consultation with, to minimise adverse outcomes. There was minimal delay till review by an orthopaedic tumour specialist at Middlemore Hospital and achieving a tissue diagnosis does not expedite this.

 

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[470]

TÍTULO / TITLE:  - Preliminary experience using dynamic MRI at 3.0 tesla for evaluation of soft tissue tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Radiol. 2013 Jan;14(1):102-9. doi: 10.3348/kjr.2013.14.1.102. Epub 2012  Dec 28.

            ●● Enlace al texto completo (gratuito o de pago) 3348/kjr.2013.14.1.102

AUTORES / AUTHORS:  - Park MY; Jee WH; Kim SK; Lee SY; Jung JY

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.

RESUMEN / SUMMARY:  - OBJECTIVE: We aimed to evaluate the use of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) at 3.0 T for differentiating the benign from malignant soft tissue tumors. Also we aimed to assess whether the shorter length  of DCE-MRI protocols are adequate, and to evaluate the effect of temporal resolution. MATERIALS AND METHODS: Dynamic contrast-enhanced magnetic resonance imaging, at 3.0 T with a 1 second temporal resolution in 13 patients with pathologically confirmed soft tissue tumors, was analyzed. Visual assessment of time-signal curves, subtraction images, maximal relative enhancement at the first (maximal peak enhancement [Emax]/1) and second (Emax/2) minutes, Emax, steepest slope calculated by using various time intervals (5, 30, 60 seconds), and the start of dynamic enhancement were analyzed. RESULTS: The 13 tumors were comprised of seven benign and six malignant soft tissue neoplasms. Washout on time-signal curves was seen on three (50%) malignant tumors and one (14%) benign one. The most discriminating DCE-MRI parameter was the steepest slope calculated, by using at 5-second intervals, followed by Emax/1 and Emax/2. All of the steepest slope values occurred within 2 minutes of the dynamic study. Start of dynamic enhancement did not show a significant difference, but no malignant tumor rendered a value greater than 14 seconds. CONCLUSION: The steepest slope and early relative enhancement have the potential for differentiating benign from malignant soft tissue tumors. Short-length rather than long-length DCE-MRI protocol may be adequate for our purpose. The steepest slope parameters require a short temporal resolution, while maximal peak enhancement parameter may be more optimal for a longer temporal resolution.

 

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[471]

TÍTULO / TITLE:  - Effects of resveratrol on vascular endothelial growth factor expression in osteosarcoma cells and cell proliferation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2012 Oct;4(4):837-839. Epub 2012 Jul 25.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.824

AUTORES / AUTHORS:  - Liu Z; Li Y; Yang R

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100;

RESUMEN / SUMMARY:  - The aim of the current study was to investigate the effects of resveratrol (Res)  on vascular endothelial growth factor (VEGF) expression and cell proliferation in the human osteosarcoma cell line U20S. U20S cells were treated with Res at various concentrations (0, 10, 20 and 40 mumol/l) for various times (24, 48 and 72 h). The inhibitory effect of Res on U20S proliferation was observed using methyl thiazolyl tetrazolium (MTT) colorimetry. VEGF expression was determined using real-time polymerase chain reaction (RT-PCR) and western blot analysis. The inhibitory effect of Res on U20S proliferation increased as the concentration of  Res increased. The inhibitory effect also increased with time. Res had an inhibitory effect on VEGF expression and significantly inhibited U20S cell proliferation. Res may exert an anti-osteosarcoma effect by inhibiting VEGF expression in tumor cells.

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[472]

TÍTULO / TITLE:  - The decreased metastatic potential of rhabdomyosarcoma cells obtained through MET receptor downregulation and the induction of differentiation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cell Death Dis. 2013 Jan 17;4:e459. doi: 10.1038/cddis.2012.199.

            ●● Enlace al texto completo (gratuito o de pago) 1038/cddis.2012.199

AUTORES / AUTHORS:  - Miekus K; Lukasiewicz E; Jarocha D; Sekula M; Drabik G; Majka M

INSTITUCIÓN / INSTITUTION:  - Department of Transplantation, Polish-American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland.

RESUMEN / SUMMARY:  - Rhabdomyosarcoma (RMS) is the most common type of pediatric soft tissue sarcoma.  The MET receptor has an important role in the biology of RMS, and its overexpression and hyperactivation correlate with the metastatic ability of RMS.  Consequently, interfering with MET expression or functionality may constitute a sound strategy for reducing the progression and metastatic potential of RMS. Our  study reveals that downregulation of the MET receptor leads to changes in the morphology of ARMS cell in vivo. Tumors acquire a spindle shape that is characteristic of muscle fibers. Inhibition of MET expression or function leads to (i) a decreased expression of the early myogenic marker MyoD, (ii) a decreased ability of ARMS cells to metastasize to bone marrow cavities, (iii) downregulation of CXCR4 receptor expression and (iv) a decreased migration of MET-depleted cells towards gradients of HGF and SDF-1. Finally, we demonstrate that in vitro differentiation of alveolar RMS cells decreases their metastatic behavior by reducing both the expression of the MET and CXCR4 receptors and their migratory response to HGF and SDF-1. These findings suggest that blockers of MET  receptor function and inducers of RMS cells differentiation may be clinically useful for reducing the aggressiveness and metastatic potential of RMS and may have significant implications for its treatment.

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[473]

TÍTULO / TITLE:  - Leiomyosarcoma of the right inferior pulmonary vein: 2 years survival with multimodality therapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gen Thorac Cardiovasc Surg. 2012 Dec 10.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11748-012-0192-2

AUTORES / AUTHORS:  - Galeone A; Validire P; Debrosse D; Folliguet T; Laborde F

INSTITUCIÓN / INSTITUTION:  - Department of Cardiac Surgery, Institut Mutualiste Montsouris, 42 Bd Jourdan, 75014, Paris, France, a.galeone@email.it.

RESUMEN / SUMMARY:  - Primary leiomyosarcoma of the heart is an extremely rare and aggressive tumor. The authors report a case of a 29-year-old man with a leiomyosarcoma of the right inferior pulmonary vein who underwent surgery, chemotherapy, and radiotherapy. The patient experienced two local recurrences and he finally died 2 years after onset of symptoms because of multiple distal metastases.

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[474]

TÍTULO / TITLE:  - Associations between uterine fibroids and lifestyles including diet, physical activity and stress: a case-control study in China.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asia Pac J Clin Nutr. 2013;22(1):109-17. doi: 10.6133/apjcn.2013.22.1.07.

AUTORES / AUTHORS:  - He Y; Zeng Q; Dong S; Qin L; Li G; Wang P

INSTITUCIÓN / INSTITUTION:  - Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, 100191, China. wpeiyu@bjmu.edu.cn; zq301@126.com.

RESUMEN / SUMMARY:  - This study was conducted to investigate the associations between uterine fibroids and lifestyles including diet, physical activity and stress from October 2009 to  April 2011 in China. This case-control study composed of 73 women with uterine fibroids and 210 women without fibroids. Uterine fibroid cases were confirmed by  ultrasound diagnosis or hysterectomy surgery. Information on women’s dietary habits, physical activity and stress status were collected with a validated self-administered questionnaire. A logistic regression model was used to estimate the odds ratios (OR) after controlling for age, gravidity and parity. We found that vegetable and fruit intakes and occupational intensity played positive effects on uterine fibroids. For premenopausal women, vegetable and fruit intakes (OR = 0.5; 95% CI: 0.3, 0.9) and occupational intensity (OR = 0.2; 95% CI: 0.1, 0.6) significantly decreased the risk of fibroids; conversely, BMI significantly  increased the risk (OR = 1.2; 95% CI: 1.0, 1.4). However, the associations for postmenopausal women were not significant. Our findings suggested protective roles for vegetable and fruit intakes and occupational intensity on uterine fibroids, and supported the hypothesis that high BMI only increased the risk of uterine fibroids in premenopausal women.

 

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[475]

TÍTULO / TITLE:  - Long lasting clinical response to chemotherapy for advanced uterine leiomyosarcoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Case Rep. 2013 Jan 24;7(1):29.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1752-1947-7-29

AUTORES / AUTHORS:  - Ridolfi C; Pasini G; Drudi F; Barzotti E; Santelmo C; Polselli A; Ravaioli A

RESUMEN / SUMMARY:  - ABSTRACT: INTRODUCTION: Uterine leiomyosarcoma is one of the most frequent uterine sarcomas. In the metastatic setting it is sensitive to doxorubicin, ifosfamide, gemcitabine, docetaxel and a few other drugs, but time to progression is generally short. For this reason prognosis is often poor and there are few reports in the literature of long responders. CASE PRESENTATION: We report a case of a 40-year-old Caucasian woman with metastatic uterine leiomyosarcoma who began treatment six years before the presentation of this case report and for the following six years underwent ten lines of chemotherapy, achieving excellent results and a good quality of life. Among the treatments administered we observed a long response to temolozomide, an unconventional drug for this kind of disease. CONCLUSION: Although there are few chemotherapeutic options for the management of metastatic uterine leiomyosarcoma, a small number of patients have an unexpected  long lasting response to treatment. For this reason further research is needed to identify new therapeutic agents and the predictive factors for the achievement of response.

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[476]

TÍTULO / TITLE:  - A case of congenital infantile fibrosarcoma of sigmoid colon manifesting as pneumoperitoneum in a newborn.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Korean Med Sci. 2013 Jan;28(1):160-3. doi: 10.3346/jkms.2013.28.1.160. Epub 2013 Jan 8.

            ●● Enlace al texto completo (gratuito o de pago) 3346/jkms.2013.28.1.160

AUTORES / AUTHORS:  - Kim HY; Cho YH; Byun SY; Park KH

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Surgery, Department of Surgery, Pusan National University School of Medicine, Yangsan, Korea.

RESUMEN / SUMMARY:  - Congenital infantile fibrosarcoma (CIF) is a rare soft-tissue tumor in the pediatric age group and seldom involves the gastrointestinal tract. A 2-day-old boy was transferred to our hospital with a pneumpoperitoneum. After emergency operation, we could find a solid mass wrapping around a sigmoid colon and performed a segmental resection of sigmoid colon including a mass. Histopathologic examination showed an infantile fibrosarcoma origining from the muscular layer of colon. The baby was discharged on the 17th hospital day and followed for 1 yr without recurrence.

 

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[477]

TÍTULO / TITLE:  - Late post transplant HIV infection with BK viremia and allograft tuberculosis in  a renal transplant recipient with Kaposi sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Nephrol. 2012 Sep;22(5):388-91. doi: 10.4103/0971-4065.103929.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0971-4065.103929

AUTORES / AUTHORS:  - Viswanathan V; Kandasamy V; Reddy YN; Reddy YN; Kurien A; Mathew M; Abraham G

INSTITUCIÓN / INSTITUTION:  - Department of Medicine and Tanker Foundation, Madras Medical Mission, Chennai, India.

RESUMEN / SUMMARY:  - In this report, we discuss a case of a 51-year-old African renal transplant who presented with metastatic Kaposi sarcoma 1 year after transplant. The Kaposi sarcoma was treated with a switch of immunosuppressants and chemotherapy. Six years after transplant, he presented with chronic allograft nephropathy, allograft tuberculosis, BK viremia, and was diagnosed to have contracted HIV infection.

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[478]

TÍTULO / TITLE:  - Esophageal duplication cyst masquerading as a stromal tumor in an adult.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg. 2011 Dec;73(6):441-3. doi: 10.1007/s12262-011-0250-5. Epub 2011 Apr 8.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12262-011-0250-5

AUTORES / AUTHORS:  - Mansard MJ; Rao U; Rebala P; Rao GV; Reddy DN

INSTITUCIÓN / INSTITUTION:  - Asian Institute of Gastroenterology, H.No:6-3-661, Somajiguda, Hyderabad, 500082  India.

 

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[479]

TÍTULO / TITLE:  - Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chin Med J (Engl). 2013 Jan;126(2):231-7.

AUTORES / AUTHORS:  - Stanczyk M; Gewartowska M; Swierkowski M; Grala B; Maruszynski M

INSTITUCIÓN / INSTITUTION:  - Department of General, Oncologic and Vascular Surgery, Military Health Service Institute, Warsaw, Poland; Department of Surgery, Wolski Hospital, Warsaw, Poland (Email: stanczyk@poczta.onet.pl).

RESUMEN / SUMMARY:  - BACKGROUND: The development of angiosarcoma in oedematous tissue is referred to as Stewart-Treves syndrome (STS). This rare and fatal complication is associated  with chronic post mastectomy lymphoedema and radiotherapy for breast cancer. Angiosarcoma spread is facilitated by the formation of blood vessels (angiogenesis) and lymph vessels (lymphangiogenesis). In the future antiangiogenic therapy may improve the poor outcome of current treatments. There  was evidence that blocking the angiogenenesis would inhibit progression of angiosarcoma. It seems reasonable to hypothesize that blocking the lymphangiogenesis may yield similar results. Although angiosarcomas commonly derive from blood vessels, in case of STS angiosarcomas chronic lymphoedema may suggest its lymphatic origin. The goal of this study was to visualize interstitial space and lymphatics in the central and peripheral regions of STS angiosarcoma. METHODS: On tissue samples obtained from STS angiosarcoma we have performed: first colour stereoscopic lymphography to visualise the morphology of  lymphatic vessels and extracellular spaces, second immunohistochemical staining specific for lymphatic vessels endothelium (LYVE-1) and blood endothelial cells (CD31, factor VIII) and prolymphangiogenic vascular endothelial growth factor (VEGF-C) for precise identification of lymphatic endothelia. STS angiosarcoma morphology was assessed by comparison of pictures obtained on lymphography, microscopy and confocal microscopy. RESULTS: STS angiosarcomas present heterogenous morphology with areas dominated by hemangiosarcoma and lymphangiosarcoma structures. STS angiosarcoma expressed phenotypes of both blood and lymphatic endothelia. LYVE-1 and VEGF-C is expressed by STS angiosarcoma and  may be used to discriminate tumour differentiation. Morphology of lymphatic vessels and spaces in the tumour suggest absence of their normal lymphatic function. CONCLUSIONS: Our results confirmed both hemangio- and lymphangiogenic origin of STS angiosarcoma. Expression of VEGF-C makes STS angiosarcoma a good candidate for targeted antilymphangiogenic therapy. However, morphology of intratumoral lymphatics on colour lymphography suggested their impaired function, which can hamper drug distribution.

 

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[480]

TÍTULO / TITLE:  - The Transcription Factor Sp3 Regulates the Expression of a Metastasis-Related Marker of Sarcoma, Actin Filament-Associated Protein 1-Like 1 (AFAP1L1).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e49709. doi: 10.1371/journal.pone.0049709. Epub 2013 Jan 9.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0049709

AUTORES / AUTHORS:  - Kajita Y; Kato T Jr; Tamaki S; Furu M; Takahashi R; Nagayama S; Aoyama T; Nishiyama H; Nakamura E; Katagiri T; Nakamura Y; Ogawa O; Toguchida J

INSTITUCIÓN / INSTITUTION:  - Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan ; Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

RESUMEN / SUMMARY:  - We previously identified actin filament-associated protein 1-like 1 (AFAP1L1) as  a metastasis-predicting marker from the gene-expression profiles of 65 spindle cell sarcomas, and demonstrated the up-regulation of AFAP1L1 expression to be an  independent risk factor for distant metastasis in multivariate analyses. Little is known, however, about how the expression of AFAP1L1 is regulated. Luciferase reporter assays showed tandem binding motives of a specificity protein (Sp) located at -85 to -75 relative to the transcriptional start site to be essential  to the promoter activity. Overexpression of Sp1 and Sp3 proteins transactivated the proximal AFAP1L1 promoter construct, and electrophoretic mobility shift assays showed that both Sp1 and Sp3 were able to bind to this region in vitro. Chromatin immunoprecipitation experiments, however, revealed that Sp3 is the major factor binding to the proximal promoter region of the AFAP1L1 gene in AFAP1L1- positive cells. Treatment with mithramycin A, an inhibitor of proteins binding to GC-rich regions, prevented Sp3 from binding to the proximal promoter region of AFAP1L1 and decreased its expression in a dose-dependent manner. Finally, knocking down Sp3 using small inhibitory RNA duplex (siRNA) reduced AFAP1L1 expression significantly, which was partially restored by expressing siRNA-resistant Sp3. These findings indicate a novel role for Sp3 in sarcomas as  a driver for expression of the metastasis-related gene AFAP1L1.

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[481]

TÍTULO / TITLE:  - CD133 expression in osteosarcoma and derivation of CD133+ cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Med Report. 2013 Feb;7(2):577-84. doi: 10.3892/mmr.2012.1231. Epub 2012 Dec 13.

            ●● Enlace al texto completo (gratuito o de pago) 3892/mmr.2012.1231

AUTORES / AUTHORS:  - Li J; Zhong XY; Li ZY; Cai JF; Zou L; Li JM; Yang T; Liu W

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, The Fourth People’s Hospital of Jinan/The Jinan Military General Hospital, Jinan 250031, P.R. China.

RESUMEN / SUMMARY:  - Cluster of differentiation 133 (CD133) is recognized as a stem cell marker for normal and cancerous tissues. Using cell culture and realtime fluorescent polymerase chain reaction, CD133 expression was analyzed in osteosarcoma tissue and Saos2 cell lines. In addition, cancer stem cellrelated gene expression in the Saos2 cell line was determined to explore the mechanisms underlying tumorigenesis and high drug resistance in osteosarcoma. CD133+ cells were found to be widely distributed in various types of osteosarcoma tissue. Following cell culture, cells entered the G2/M and S cell cycle stages from G0/G1. Levels of CD133+ cells decreased to normal levels rapidly over the course of cell culture. Colony forming efficiency was higher in the CD133+ compared with the CD133 subpopulation of Saos2 cells. Expression levels of stem cellrelated genes, including multidrug  resistance protein 1 (MDR1) and sex determining region Ybox 2 (Sox2) in the CD133+ subpopulation of cells were found to be significantly higher compared with the CD133 subpopulation. These observations indicate that CD133+ Saos2 cells exhibit stem cell characteristics, including low abundance, quiescence and a high potential to undergo differentiation, as well as expression of key stem cell regulatory and drug resistance genes, which may cause osteosarcoma and high drug  resistance.

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[482]

TÍTULO / TITLE:  - The expression of KIT receptor dimers in gastrointestinal stromal tumors independent of c-kit mutation and SCF expression is associated with high-risk stratification.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2012 Oct;4(4):805-811. Epub 2012 Jul 11.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.797

AUTORES / AUTHORS:  - Qiu C; Liu X; Bai C; Ma DL

INSTITUCIÓN / INSTITUTION:  - Departments of Pathology and.

RESUMEN / SUMMARY:  - Although the dimerization of KIT, a receptor tyrosine kinase, plays a major role  in a number of tumors, correlations between the clinicopathological parameters and KIT receptor dimers have not been identified. In the current study, a method  for the detection of KIT receptor dimer expression was described and correlations between the clinicopathological parameters and KIT receptor dimers were analyzed. A single center cohort study of 49 patients with gastrointestinal stromal tumors  (GISTs) was conducted to analyze the expression of KIT receptor dimers by SDS-PAGE, Native-PAGE and modified Native-PAGE. Immunohistochemistry was used to  examine the expression of ki-67, c-kit and stem cell factor (SCF). Mutations of the c-kit gene were examined in 48 GISTs according to the polymerase chain reaction (PCR) and direct sequencing methods. Based on the data, a signal for the KIT receptor monomer was obtained by SDS-PAGE. Faint bands were observed on the nitrocellulose membrane by Native-PAGE, while clear bands were identified for KIT receptor dimers and monomers using modified Native-PAGE (15 out of 49 cases). The tumor size was larger in KIT receptor dimer-positive cases compared with that in  KIT receptor dimer-negative cases. Analysis of KIT receptor dimer expression levels and risk stratification demonstrated that KIT receptor dimer-positive cases belonged to the higher risk classification. In addition, there was no significant correlation between the existence of KIT receptor dimers and c-kit gene mutations, including SCF expression. In conclusion, this study established a method for the detection of the existence of KIT receptor dimers in tissues and confirmed that KIT receptor dimers were correlated with risk stratification. Data also indicated that ligand-dependent SCF/KIT dimerization is an independent crucial mechanism in GIST cell proliferation and increases the risk of GIST. Therefore, blocking KIT dimerization may prove to be an effective approach for the treatment of GISTs.

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[483]

TÍTULO / TITLE:  - The C2 ganglion sectioning epidural approach to craniocervical junction chordoma: A technical case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neurol India. 2012 Nov-Dec;60(6):638-42. doi: 10.4103/0028-3886.105201.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0028-3886.105201

AUTORES / AUTHORS:  - Hagihara N; Matsushima T; Kawashima M; Hikita T

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Faculty of Medicine, Saga University 5-5-1 Nabeshima, Saga, Japan.

RESUMEN / SUMMARY:  - In chordoma, complete surgical removal of the epidural tumor should be the first  choice of treatment. Numerous surgical approaches to clival chordoma have been described: anterior approaches, lateral approaches, and posterolateral approaches. A multistaged operation with a combination of these approaches is generally performed. We used three approaches to remove a clival chordoma extending from the lower clivus anteriorly to the anterior perivertebral space and inferiorly to the C2 level. The epidural posterolateral approach through the  vertebral artery (VA)-C2 interval space after resection of the C2 dorsal ganglion was the most effective. To our knowledge, the epidural posterolateral approach below VA, referred to as C2 ganglion sectioning epidural approach has not been reported as an independent approach in detail. We report a two-year-old girl with a lower clival chordoma which has been excised using C2 ganglion sectioning epidural approach.

 

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[484]

TÍTULO / TITLE:  - Pediatric bladder rhabdomyosarcoma: Report of organ sparing treatment of two cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Urol. 2012 Dec 3. pii: S1477-5131(12)00279-3. doi: 10.1016/j.jpurol.2012.11.005.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jpurol.2012.11.005

AUTORES / AUTHORS:  - Ozturk U; Goktug HN; Tuygun C; Sener NC; Yesil S; Bakirtas H; Imamoglu MA

INSTITUCIÓN / INSTITUTION:  - Ministry of Health, Ankara Diskapi Yildirim Beyazit Education and Research Hospital, Department of Urology, Ankara, Turkey. Electronic address: ufukozturk71@gmail.com.

RESUMEN / SUMMARY:  - Pediatric rhabdomyosarcoma cases require multimodality therapy. Here, we present  two cases treated by tumor resection followed by chemotherapy, and discuss the bladder preserving treatment of this uncommon disease.

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[485]

TÍTULO / TITLE:  - Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Onco Targets Ther. 2012;5:433-8. doi: 10.2147/OTT.S38645. Epub 2012 Dec 12.

            ●● Enlace al texto completo (gratuito o de pago) 2147/OTT.S38645

AUTORES / AUTHORS:  - Karanikas M; Machairiotis N; Zarogoulidis P; Stylianaki A; Corcoutsakis N; Mitrakas A; Touzopoulos P; Lyratzopoulos N; Kouklakis G; Spanoudakis M; Polychronidis A

INSTITUCIÓN / INSTITUTION:  - 1st University Surgery Department, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.

RESUMEN / SUMMARY:  - We report the case of a 64-year-old woman with a gastrointestinal stromal tumor and a diffuse large cell lymphoma. For this case, we conducted a literature review in an attempt to correlate these two neoplasms on a molecular basis. Diffuse large cell lymphoma is a subtype of non-Hodgkin lymphomas. The etiologic  factor of these lymphomas is considered to be the mutations or allelic losses of  the TP53 tumor suppressor gene and the overexpression of the bcl-2 oncogene. Gastrointestinal stromal tumors are mesenchymal tumors, which are typically defined by the expression of c-KIT (CD117) and CD34 genes in the tumor cells. Although there are references to dispersants in the literature about patients with both non-Hodgkin lymphoma and gastrointestinal stromal tumors, there is no common molecular pathway between these two diseases. In conclusion, there is no indication that these two neoplasms are relevant on a molecular basis.

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[486]

TÍTULO / TITLE:  - A case of inguinal sparganosis mimicking myeloid sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Parasitol. 2012 Dec;50(4):353-5. doi: 10.3347/kjp.2012.50.4.353. Epub 2012 Nov 26.

            ●● Enlace al texto completo (gratuito o de pago) 3347/kjp.2012.50.4.353

AUTORES / AUTHORS:  - Yeo JY; Han JY; Lee JH; Park YH; Lim JH; Lee MH; Kim CS; Yi HG

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, Inha University College of Medicine, Incheon 400-711, Korea.

RESUMEN / SUMMARY:  - We report here a case of inguinal sparganosis, initially regarded as myeloid sarcoma, diagnosed in a patient undergone allogeneic hematopoietic transplantation (HSCT). A 56-year-old male patient having myelodysplastic syndrome was treated with allogeneic HSCT after myeloablative conditioning regimen. At day 5 post-HSCT, the patient complained of a painless palpable mass on the left scrotum and inguinal area. Pelvic magnetic resonance imaging and computed tomography revealed suspected myeloid sarcoma. Gun-biopsy was performed, and the result revealed eosinophilic infiltrations without malignancy. Subsequent serologic IgG antibody test was positive for sparganum. Excisional biopsy as a therapeutic diagnosis was done, and the diagnosis of sparganosis was confirmed eventually. This is the first report of sparganosis after allogeneic HSCT mimicking myeloid sarcoma, giving a lesson that the physicians have to consider the possibility of sparganosis in this clinical situation and perform adequate diagnostic and therapeutic approaches.

 

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[487]

TÍTULO / TITLE:  - A case of cutaneous malignant fibrous histiocytoma with multiple organ metastases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Kaohsiung J Med Sci. 2013 Feb;29(2):111-5. doi: 10.1016/j.kjms.2012.08.019. Epub  2012 Oct 13.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.kjms.2012.08.019

AUTORES / AUTHORS:  - Suzuki S; Watanabe S; Kato H; Inagaki H; Hattori H; Morita A

INSTITUCIÓN / INSTITUTION:  - Department of Geriatric and Environmental Dermatology, Graduate School of Medical, Nagoya City University, Nagoya, Japan. Electronic address: drshuji@yahoo.co.jp.

RESUMEN / SUMMARY:  - Malignant fibrous histiocytoma is a soft tissue sarcoma that most commonly occurs in the extremities and rarely metastasizes cutaneously. A 79-year-old male patient consulted a dermatologist 11 months after recognizing an intractable ulcer on the right mandible. Punch biopsy revealed eosinophilic tumor cells in the dermal area and proliferation of rich spindle cells. Malignant fibrous histiocytoma or atypical fibroxanthoma was suspected and he was referred to our hospital. Red plaque tumors on the right mandible and right temple were 30 mm and 15 mm in size, respectively. The right mandible lesion was ulcerated. Immunohistochemically, the lesions were positive for CD10, CD74 and alpha-smooth  muscle actin. Radiological analysis revealed multiple organ metastases, including bone, liver, lung and skin on the right temple. The patient was diagnosed with malignant fibrous histiocytoma, stage IV and died 8 weeks after the first visit due to respiratory failure. Cutaneous malignant fibrous histiocytoma has a poor prognosis resulting in death.

 

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[488]

TÍTULO / TITLE:  - Esophageal tuberculosis mimicking submucosal leiomyoma- report of a case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg. 2011 Dec;73(6):465-6. doi: 10.1007/s12262-011-0266-x. Epub 2011 Apr 30.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12262-011-0266-x

AUTORES / AUTHORS:  - Sood D; Singh T; Singh A; Chaudhary A

INSTITUCIÓN / INSTITUTION:  - Sir Ganga Ram Hospital, New Delhi, India.

RESUMEN / SUMMARY:  - We present a case of primary esophageal tuberculosis presenting as solitary submucosal mass in cervical esophagus with clinical features of dysphagia, thus mimicking a submucosal leiomyoma on imaging in a 39 year old lady. Excision of this mass revealed features suggestive of tuberculosis on histopathology.

 

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[489]

TÍTULO / TITLE:  - Large vulvar lipoma following episiotomy: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Niger J Med. 2012 Jul-Sep;21(3):357-8.

AUTORES / AUTHORS:  - Agu PU; Okeke TC; Ezugwu EC; Obi SN

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria. agu_uche@yahoo.com

RESUMEN / SUMMARY:  - Vulvar lipomas are rare few cases have been reported in the world literature. We  document a case of large soft vulvar mass following episiotomy in a 23-year-old primipara. The mass was excised and histologic examination confirmed lipoma.

 

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[490]

TÍTULO / TITLE:  - Acute Renal Failure in the Postpartum due to Calcified Myoma: A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - West Afr J Med. 2012 Jul-Aug;31(3):204-6.

AUTORES / AUTHORS:  - Diop MM; Diao B; Toure PS; Leye MY; Tall A; Ka MM

INSTITUCIÓN / INSTITUTION:  - Centre hospitalier regional de Thies / UFR des Sciences de la Sante de Thies. PO  Box: A 34 Thies / Senegal.

RESUMEN / SUMMARY:  - BACKGROUND: It has been reported that delivery can be a cause of urine retention. This complication occurs especially in case which are associated with a pelvic mass like calcified uterine myoma. But this unusual aspect of myoma can make ultrasonographic traps. OBJECTIVE: To report an unusual case of calcified uterine myoma which was unnoticed during pregnancy and made so obstructive renal failure  few days after the delivery. CASE REPORT: Seven days after delivery aTwenty-nine-year-old Senegalese woman was admitted at a private hospital for a slight alteration of consciousness(Glasgow Coma Scale at 12). Emergency check-up  showed an acute obstructive renal failure. Biological investigations showed ascendancy of granulocytes, deterioration of renal function with creatinin in 78  mg / l and urea in 1.82 g/l. Ultrasonographic examination revealed bilateral dilatation of renal calyces and an interstitial calcified uterine myoma compressing the bladder. Management consisted on a urethral catheterization of bladder, correction of hydro-electrolytic troubles and antibiotherapy (ciprofloxacin).Global evolution leads to fast fully consciousness, with disappearance of biological and ultrasonographic disorders. CONCLUSION: Calcified myoma can look like cephalic pole during pregnancy. This unusual aspect can be sometimes source of acute obstructive renal failure requiring urinary drainage in emergency. Improvement of women’s management during postpartum can prevent such complications.

 

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[491]

TÍTULO / TITLE:  - Extraskeletal Osteosarcoma of the Pleura:Report of a Case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2012 Nov 17.

AUTORES / AUTHORS:  - Shiota H; Yasukawa T; Hirai A; Chiyo M; Yusa T; Hiroshima K

INSTITUCIÓN / INSTITUTION:  - Department of General Thoracic Surgery, Chiba Rosai Hospital, Ichihara, Chiba, Japan.

RESUMEN / SUMMARY:  - Extraskeletal osteosarcoma is a rare malignant tumor occurring very rarely in the pleura. We herein report the case of 67-year-old man with asbestos exposure, who  underwent biopsies of the large tumor from the chest wall, and diagnosed as a suspicious of fibrosarcoma. Surgical resection was done, and the pathological diagnosis was extraskeletal osteosarcoma arising from the pleura. The differential diagnosis is malignant pleural mesothelioma with osseous and cartilaginous which is also very rare and one of the histopathological subtypes with heterologous elements. Identification of epithelial components, labeling for cytokeratins in spindle cells and its’ anatomical distribution may help to distinguish them. In the neoplasm arising from the parietal pleura, primary extraskeletal osteosarcoma of the pleura is very rare, but should be considered.

 

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[492]

TÍTULO / TITLE:  - A case of papillary fibroelastoma in the left ventricle.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Intern Med. 2013 Jan;28(1):89-93. doi: 10.3904/kjim.2013.28.1.89. Epub 2012 Dec 28.

            ●● Enlace al texto completo (gratuito o de pago) 3904/kjim.2013.28.1.89

AUTORES / AUTHORS:  - Hyun JY; Jung IH; Lee HJ; Lee SJ; Kim JS; Na CY; Ro YM

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea.

RESUMEN / SUMMARY:  - Cardiac papillary fibroelastoma (CPF) is a rare and benign primary cardiac neoplasm of unknown prevalence. The incidence of CPF in the left ventricle is lower than that in other parts of the heart. A 65-year-old female was referred to our cardiology department for evaluation of a cardiac mass of the left ventricle. Transthoracic echocardiography revealed a 1.8 x 1.7 cm highly mobile round mass attached by a stalk to the apical inferior wall of the left ventricle with an echolucent area. The mass was successfully removed without any postoperative complications and was identified as a CPF.

 

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[493]

TÍTULO / TITLE:  - Superficial acral fibromyxoma of the great toe: case report and mini-review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Dermatovenerol Croat. 2012 Dec;20(4):263-6.

AUTORES / AUTHORS:  - Wakabayashi Y; Nakai N; Takenaka H; Katoh N

INSTITUCIÓN / INSTITUTION:  - Noriaki Nakai, MD, PhD, Department of Dermatology, Kyoto, Prefectural University  of Medicine Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan; nnakai@koto.kpu-m.ac.jp.

RESUMEN / SUMMARY:  - Superficial acral fibromyxoma (SAF) is a rare, distinctive, benign soft tissue tumor with a predilection for the hands and feet, first described by Fetsch et al. in 2001. Histologically, SAF tumors are unencapsulated, mostly located in the dermis or subcutis, and composed of spindled and stellate-shaped cells with random, loose storiform and fascicular growth patterns. The stromal component of  the tumor was Alcian blue-positive. The tumor cells were mostly immunopositive for CD34, vimentin, and CD99; often immunopositive for EMA; and immunonegative for S-100, HMB-45, SMA, desmin, and keratin. There have been 19 reports of 149 SAF cases in the English language literature. However, SAF is not widely recognized because it is an uncommon occurrence that has been described only relatively recently. Herein, we report a case of SAF and describe the clinicopathologic characteristics based on a review of published SAF cases from July 2001 to July 2011.

 

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[494]

TÍTULO / TITLE:  - Gastro-intestinal stromal tumour—a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Indian Med Assoc. 2012 Jun;110(6):404-5.

AUTORES / AUTHORS:  - Agashe SR; Patil PP; Phansopkar MA; Shivani A; Kulkarni SH

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Bharati Vidyapeeth University Medical College and Hospital, Sangli 416416.

RESUMEN / SUMMARY:  - Gastro-intestinal stromal tumours are rare tumours of the gastro-intestinal tract. Among non-epithelial tumours of gastro-intestinal tract, gastro-intestinal stromal tumours are the commonest but as they are not extensively documented, they are underestimated, poorly understood and inadequately treated for various reasons, particularly at peripheral centres in India. The gravity of the problem  increases further as these tumours respond poorly to conventional cytotoxic chemotherapy and radiation therapy. Here a case of gastro-intestinal stromal tumour is reported. The patient was a 35-year-old male who was admitted with evidence of subacute intestinal obstruction. The haematological and biochemical tests showed moderate anaemia, raised serum aminotransferase aspartate (AST, SGOT) and mild hypoproteinaemia. Laparatomy revealed a jejunal tumour which was resected. The routine histopathological examination revealed a spindle cell tumour suggestive of gastro-intestinal stromal tumour -intermediate risk group. Immunohistochemical study showed strong positivity for c-kit confirming the diagnosis of gastro-intestinal stromal tumour. The patient was then referred to oncology centre for further management.

 

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[495]

TÍTULO / TITLE:  - Giant Primary Mesenchymal Chondrosarcoma of the Lung: Case Report and Review of Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ann Thorac Cardiovasc Surg. 2012 Nov 30.

AUTORES / AUTHORS:  - Mei B; Lai YL; He GJ; Shou YN; Liu J

INSTITUCIÓN / INSTITUTION:  - Department of Cardiothoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.

RESUMEN / SUMMARY:  - Mesenchymal chondrosarcoma, a rare malignant tumor, was predominantly occurring in the bone and may involve somatic soft tissue but it is extremely rare in the lung.We report the case of a 20-year-old female who presented with a 2-month history of irritant nonproductive cough and chest pain. The histopathologic examination revealed the tumor composed of atypical undifferentiated small cells  and islands of matured chondroid matrix typically presented as bimorphic appearances. Immunohistochemical examination revealed that the tumor cells were positive for vimentin and CD99 for all components, and to S-100 limited to the areas of cartilage. In addition, previously reported cases of primary lung mesenchymal chondrosarcoma were reviewed, and the relevant clinical knowledge regarding its clinical manifestations, diagnosis, and treatment were discussed.

 

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[496]

TÍTULO / TITLE:  - Chondromyxoid fibroma of the clavicle extending to the adjacent joint: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Orthop Surg (Hong Kong). 2012 Dec;20(3):402-5.

AUTORES / AUTHORS:  - Aggarwal A; Bachhal V; Soni A; Rangdal S

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

RESUMEN / SUMMARY:  - Chondromyxoid fibroma is a rare benign bone tumour usually involving bones of the lower extremity in young adults. We present a case of chondromyxoid fibroma of the left clavicle extending to the adjacent joint in a 84-year-old man. The tumour had breached the hyaline cartilage of acromioclavicular joint. The tumour  was excised en bloc, and the humeral head was curetted and grafted with autogenous cancellous bone. Postoperatively, the patient had an uneventful recovery and regained excellent function of the left shoulder without any pain or stiffness. At the 18-month follow-up, there was no sign of recurrence.

 

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[497]

TÍTULO / TITLE:  - Immunohistochemical validation of TLE1, a novel marker, for synovial sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Med Res. 2012 Nov;136(5):766-75.

AUTORES / AUTHORS:  - Rekhi B; Basak R; Desai SB; Jambhekar NA

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Tata Memorial Hospital, Mumbai, India.

RESUMEN / SUMMARY:  - Background & objectives: Logistic and financial constraints limit application of  several available immunohistochemical (IHC) markers and molecular analysis in every case of synovial sarcoma, diagnosed in our settings. Recently, TLE1 has been recognized as a robust IHC marker for diagnosing a synovial sarcoma. Here, we present IHC features of synovial sarcomas, including TLE1 expression in these  cases and in some other tumours. Methods: Conventional sections from 42 synovial  sarcomas (30 retrospective & 12 prospectively diagnosed) were subjected to TLE1 IHC staining, including 21 tumours confirmed with molecular testing. TLE1 immunostaining was graded from 0, 1+, 2+, 3+, with 2+ or 3+ grades interpreted as positive staining. Results: Of the 42 tumours, 26 (61.9%) were of monophasic spindle cell type, 13 biphasic type (30.9%), two (4.7%) calcifying type and remaining one (2.3%) was a poorly differentiated synovial sarcoma. On immunohistochemistry (IHC), tumours were positive for epithelial membrane antigen (EMA) (26/34, 76.4%), cytokeratin (CK)7 (6/10, 60%), CK/MNF116 (6/21, 28.6%), B cell lymphoma 2 (BCL2) (36/37, 97.3%), cluster of differentiation molecule 99 (MIC2) (23/31, 74.1%) and transducin-like enhancer of split 1 (TLE1) (40/42, 95.2%), while negative for CD34 in all 21 tumours, wherever performed. TLE1 was also positive in tumour controls, including schwannomas (5/5, 100%), neurofibromas (2/2, 100%), malignant peripheral nerve sheath tumors (2/12, 17%) and Ewing sarcomas (4/10, 40%). TLE1 sensitivity for diagnosis of synovial sarcomas was 95.2 per cent. Its overall specificity was 63.7 per cent, whereas with regards to tumors forming its closest differential diagnoses, its specificity was 72 per cent. Interpretation & conclusions: Although molecular confirmation is the diagnostic gold standard for synovial sarcoma, TLE1, in view  of its high sensitivity may be a useful marker within the optimal IHC panel comprising EMA, BCL2, MIC2, CD34 and CK7, especially on small biopsy samples, for substantiating a diagnosis of synovial sarcoma. Awareness of TLE1 expression in other tumours and its correct interpretation are necessary.

 

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[498]

TÍTULO / TITLE:  - Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS Pathog. 2012 Nov;8(11):e1003048. doi: 10.1371/journal.ppat.1003048. Epub 2012 Nov 29.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.ppat.1003048

AUTORES / AUTHORS:  - Chen W; Sin SH; Wen KW; Damania B; Dittmer DP

INSTITUCIÓN / INSTITUTION:  - Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

RESUMEN / SUMMARY:  - Heat-shock protein 90 (Hsp90) inhibitors exhibit activity against human cancers.  We evaluated a series of new, oral bioavailable, chemically diverse Hsp90 inhibitors (PU-H71, AUY922, BIIB021, NVP-BEP800) against Kaposi sarcoma (KS). All Hsp90 inhibitors exhibited nanomolar EC(50) in culture and AUY922 reduced tumor burden in a xenograft model of KS. KS is associated with KS-associated herpesvirus (KSHV). We identified the viral latency associated nuclear antigen (LANA) as a novel client protein of Hsp90 and demonstrate that the Hsp90 inhibitors diminish the level of LANA through proteasomal degradation. These Hsp90 inhibitors also downregulated EphA2 and ephrin-B2 protein levels. LANA is essential for viral maintenance and EphA2 has recently been shown to facilitate KSHV infection; which in turn feeds latent persistence. Further, both molecules are required for KS tumor formation and both were downregulated in response to Hsp90 inhibitors. This provides a rationale for clinical testing of Hsp90 inhibitors in KSHV-associated cancers and in the eradication of latent KSHV reservoirs.

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[499]

TÍTULO / TITLE:  - Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Jan;5(1):201-207. Epub 2012 Oct 19.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.981

AUTORES / AUTHORS:  - Lu Q; Lv G; Kim A; Ha JM; Kim S

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China ;

RESUMEN / SUMMARY:  - Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Recent studies have shown that extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) promotes adhesion, invasion and metastasis of malignant tumor cells. The aim of this study was to investigate the impact of EMMPRIN/CD147 expression on prognosis and its correlation with clinicopathological characteristics in patients with osteosarcoma. The expression of EMMPRIN/CD147 in 55 surgical specimens from patients with osteosarcoma at stage IIA or above, 15 non-tumor rib bone tissues, three human osteosarcoma cell  lines (Saos-2, U-2OS and MG-63), the human osteoblast cell line HOB and the malignant melanoma cell line A375 were examined by immunohistochemistry, western  blot analysis and ELISA, respectively. The potential association of the levels of EMMPRIN/CD147 expression in osteosarcoma specimens with the overall survival of patients was statistically analyzed. We found that the EMMPRIN/CD147 was expressed in 45 out of 55 osteosarcomas, with immunoreactivity primarily within the membrane and cytoplasm of tumor cells, but not in the non-tumor bone tissues. We also observed that EMMPRIN/CD147 was expressed in Saos-2, U-2OS, MG-63 and A375, but not in HOB cells. The levels of EMMPRIN/CD147 expression correlated positively with the pathological degree of osteosarcoma and negatively with the survival period of patients with osteosarcoma. The expression of EMMPRIN/CD147 is a potential factor in the development and prognosis of osteosarcoma and may be a  novel therapeutic target of human osteosarcoma.

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[500]

TÍTULO / TITLE:  - Expression of IGF-1 receptor in KIT/PDGF receptor-alpha wild-type gastrointestinal stromal tumors with succinate dehydrogenase complex dysfunction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Future Oncol. 2013 Jan;9(1):121-6. doi: 10.2217/fon.12.170.

            ●● Enlace al texto completo (gratuito o de pago) 2217/fon.12.170

AUTORES / AUTHORS:  - Nannini M; Astolfi A; Paterini P; Urbini M; Santini D; Catena F; Indio V; Casadio R; Pinna AD; Biasco G; Pantaleo MA

INSTITUCIÓN / INSTITUTION:  - Department of Hematology & Oncological Sciences ‘L&A Seragnoli’, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.

RESUMEN / SUMMARY:  - KIT/PDGF receptor-alpha (PDGFRA) wild-type (WT) gastrointestinal stromal tumors (GIST) are characterized by an overexpression of IGF-1 receptor (IGF1R) at the mRNA and protein level. More recently, germline and somatic mutations in succinate dehydrogenase (SDH) subunits A, B and C have been identified in KIT/PDGFRA WT sporadic GIST. Until now, the molecular basis of IGF1R overexpression in KIT/PDGFRA WT GIST has not been explained. In this brief report we investigate the status of the SDH complex at the genomic and protein level in  relation to IGF1R expression at the mRNA and protein level in seven KIT/PDGFRA WT sporadic GIST patients. We found that IGF1R was upregulated in all patients harboring SDH mutations or displaying a SDH dysfunction, with respect to KIT/PDGFRA WT GIST without SDH mutations. Western blot analysis confirmed that all patients with an upregulation of IGF1R mRNA had detectable IGF1R protein expression. This report would suggest that IGF1R overexpression in KIT/PDGFRA WT  GIST could be driven by the loss-of-function of the SDH mitochondrial complex.

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[501]

TÍTULO / TITLE:  - Trabectedin as second-line treatment in metastatic myxoid liposarcoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Case Rep. 2012 Dec 19;6(1):424.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1752-1947-6-424

AUTORES / AUTHORS:  - Pedrinaci IZ; Jurado JM; Carrillo J; Molina MC

RESUMEN / SUMMARY:  - ABSTRACT: INTRODUCTION: Soft tissue sarcomas are heterogeneous tumors that are difficult to treat. Up to 50 percent of patients develop metastatic disease and require systemic chemotherapy. Ifosfamide and doxorubicin are the two most active agents. CASE PRESENTATION: A 33-year-old Caucasian woman presented to our facility with a metastatic myxoid liposarcoma. Our patient was initially treated  with surgery and radiation therapy, but experienced three recurrences during a six-year period, the first and the last occurring while our patient was pregnant. The first recurrence, which occurred two years after diagnosis and was localized  in the left cervical and right axillary region, was treated with surgery followed by chemotherapy. Molecular analysis of this tumor showed a t(12,16) + translocation resulting in a FUS-DDIT3 or EWSR1-DDIT3 fusion. Three years later our patient experienced a second recurrence in the left supraclavicular fossa, upper thoracic and anterior mediastinum, which was treated with surgery alone. Eight months later, during the second pregnancy, our patient experienced a third  recurrence as a large cervical mass that was treated with trabectedin (1.5mg/m2/24-hour continuous infusion) for a total of 12 cycles. At that time a computed tomography scan showed long-term partial response with excellent treatment tolerability. CONCLUSIONS: This case report illustrates the potential therapeutic activity of trabectedin in patients with myxoid liposarcoma.

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[502]

TÍTULO / TITLE:  - Ewing’s Sarcoma of the Stomach; Rare Case of Ewing’s Sarcoma and Suggestion of New Treatment Strategy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastric Cancer. 2012 Dec;12(4):258-61. doi: 10.5230/jgc.2012.12.4.258. Epub 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 5230/jgc.2012.12.4.258

AUTORES / AUTHORS:  - Kim HS; Kim S; Min YD; Kee KH; Hong R

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Chosun University Hospital, School of Medicine, Chosun University, Gwangju, Korea.

RESUMEN / SUMMARY:  - Ewing’s sarcoma is a neoplasm of the undifferenciated small round cells, which generally affects the bone and deep soft tissues of children and adolescents. We  present a case of gastric Ewing’s sarcoma; a 35-year-old female who had no symptoms. While she was at a routine medical checkup, a protruding mass in her gastric antrum was incidentally found on esophagogastroduodenoscopy. Endoscopic ultrasonogram showed a submucosal mass on the same lesion and a laparosopic wedge resection was done. Pathologic gross findings showed a granular grape appearance  tissue and histoloigc examination revealed a small round cell tumor with CD 99 immunoexpression positive. In general, a combined modality therapy for Ewing’s sarcoma such as surgical resection with chemotherapy, is accepted as an effective method. However, this patient had no adjuvant chemotherapy after surgery and she  has no recurrence for eleven months.

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[503]

TÍTULO / TITLE:  - Treatment of urinary retention caused by uterine leiomyoma with a gonadotropin-releasing hormone agonist: case report and review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Female Pelvic Med Reconstr Surg. 2013 Jan-Feb;19(1):52-5. doi: 10.1097/SPV.0b013e318277d9fd.

            ●● Enlace al texto completo (gratuito o de pago) 1097/SPV.0b013e318277d9fd

AUTORES / AUTHORS:  - Chu CM; Dabney L; Hardart A

INSTITUCIÓN / INSTITUTION:  - From the St Luke’s Roosevelt Hospital Center, New York, NY.

RESUMEN / SUMMARY:  - CASE: We present a case of a symptomatic uterine leiomyoma presenting with recurrent urinary retention that was conservatively managed with a gonadotropin-releasing hormone agonist. As far as we know, this is the first reported case of a successful treatment by gonadotropin-releasing hormone agonist. We also compare other approaches to treatment of urinary retention secondary to uterine leiomyoma found in literature. CONCLUSION: Gonadotropin-releasing hormone agonists can be offered to the patient as a potential, successful nonsurgical option in select cases.

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[504]

TÍTULO / TITLE:  - Chondrosarcoma of the larynx.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Isr Med Assoc J. 2012 Nov;14(11):681-4.

AUTORES / AUTHORS:  - Buda I; Hod R; Feinmesser R; Shvero J

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center (Beilinson Campus), Petah Tikva, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. inonb@clalit.org.il

RESUMEN / SUMMARY:  - BACKGROUND: Chondrosarcoma of the larynx is a rare tumor. The most common symptom is hoarseness. Treatment is controversial. OBJECTIVES: To describe six patients with laryngeal chondrosarcoma from a single center. METHODS: The medical records  of a major tertiary hospital were reviewed for all patients with laryngeal chondrosarcoma diagnosed and treated from 1959 to 2010. Data on background, clinical treatment and outcome were collected. RESULTS: Six patients, all males with a mean age of 53.3 years, were identified. Partial laryngectomy was performed in three patients, and total laryngectomy, local excision, and partial  cricoidectomy in one patient each. Four patients had a permanent tracheostomy after surgery. One patient required postoperative chemotherapy and one radiotherapy. Follow-up time was 12-216 months (mean 102 months). Recurrence developed in two patients 2 and 8 years after initial treatment and was treated by salvage surgery in both patients. One patient died during the follow-up from an unrelated cause. The others are currently alive. CONCLUSIONS: This study supports earlier reports recommending initial treatment with partial or total laryngectomy for laryngeal chondrosarcoma. Long-term follow-up for recurrence is  advised. We recommend preserving the larynx, if possible, even if a permanent tracheostomy is necessary.

 

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[505]

TÍTULO / TITLE:  - In vitro effects of thermoablation on apoptosis of giant cell tumor of bone: a preliminary report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Assoc Thai. 2012 Sep;95 Suppl 9:S138-45.

AUTORES / AUTHORS:  - Phimolsarnti R; Charoenlap C; Ariyaboonsiri B; Wongkajornsilpa A; Waikakul S

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

RESUMEN / SUMMARY:  - BACKGROUND: Giant cell tumor of bone is a common benign aggressive bone tumor. Recurrent rate in the patients who have the tumor with soft tissue invasion is rather high. Use of strong chemicals such as phenol and liquid nitrogen to lessen the recurrent rate might not be used in this lesion. OBJECTIVE: The experiment was carried out to discover apoptotic effects of thermoablation on giant cell tumor of bone to find out a possibility to use thermoablation in the clinic in the patients with extensive lesion. MATERIAL AND METHOD: Tumor cell suspension was prepared from 4 patients who had definite diagnosis of giant cell tumor of bone. The tumor cells were subjected to thermoablation at 45, 47 and 50 degrees C for 10 to 30 minutes before were cultured at 37 degrees C for another 3 days. Osteoblasts and chondrocytes from the last 3 patients were collected,prepared and underwent thermoablation in the same fashion. Apoptosis of tumor cells, chondrocytes and osteoblasts were carried out by the use of flow cytometry. RESULTS: Thermoablation at 47 degrees C for 30 minutes resulted in < 50% chondrocyte and osteoblast apoptosis and 70-90% tumor cells apoptosis of ¾ patients. Thermoablation at 47 and 50 degrees C for 20 to 30 minutes has more negative effect on giant cell tumor of bone than chondrocytes and osteoblasts. CONCLUSION: Thermoablation might be a useful tool for local tumor control in the  clinic.

 

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[506]

TÍTULO / TITLE:  - Reduction in the vascular bed volume of uterine fibroids after hormonal treatment: evaluation with dynamic double-echo r(2)* imaging.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Magn Reson Med Sci. 2012;11(4):283-9.

AUTORES / AUTHORS:  - Okuda S; Oshio K; Asada H; Tanimoto A; Jinzaki M; Furuya M; Yoshimura Y; Kuribayashi S

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic Radiology, Keio University School of Medicine.

RESUMEN / SUMMARY:  - Purpose: To demonstrate the reduction in vascular bed volume (VBV) of uterine fibroids after administration of gonadotropin-releasing hormone analogue (GnRHa)  using magnetic resonance (MR) imaging including dynamic double-echo R(2)* imaging (DDE-R(2)*I) and to assess the value of DDE-R(2)*I as a predictor of such reduction. Methods: Twenty-one women with uterine intramural fibroids underwent MR imaging including DDE-R(2)*I before GnRHa treatment. DDE-R(2)*I was acquired using a single-section, double-echo, fast spoiled gradient recalled acquisition in the steady state (SPGR) sequence. We calculated the area under the curve (AUC) of the signal intensity on R(2)*I within a 3x3-cm(2) region of interest that served to represent the VBV. We repeated MR imaging after 2 administrations of GnRHa and repeated image analyses. We statistically analyzed correlations between (A) pre-treatment AUC (AUC(pre)) and AUC reduction and (B) AUC(pre) and volume reduction. Results: The interval between the 2 MR studies ranged from 56 to 119 days (mean: 80.4 days). The average volume of the fibroids before GnRHa treatment was 647.8 mL compared with 463.4 mL after the therapy (decreased by an average of 28.5%; P<0.0001). Meanwhile, measured AUC was reduced by 55.3% (483.4 vs. 206.5;  P<0.0001). AUC(pre) correlated with volume reduction (r=0.68), but not AUC reduction. Conclusions: We confirmed reduction in the VBV of fibroids using DDE-R(2)*I. The measurement of AUC(pre) on DDE-R(2)*I aids prediction of fibroid  volume reduction but correlates poorly with the percentage of AUC reduction.

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[507]

TÍTULO / TITLE:  - Proteomic approach toward personalized sarcoma treatment: Lessons from prognostic biomarker discovery in gastrointestinal stromal tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Proteomics Clin Appl. 2013 Jan;7(1-2):70-8. doi: 10.1002/prca.201200085.

            ●● Enlace al texto completo (gratuito o de pago) 1002/prca.201200085

AUTORES / AUTHORS:  - Kondo T; Suehara Y; Kikuta K; Kubota D; Tajima T; Mukaihara K; Ichikawa H; Kawai A

INSTITUCIÓN / INSTITUTION:  - Division of Pharmacoproteomics, National Cancer Center Research Institute, Tokyo, Japan.

RESUMEN / SUMMARY:  - Sarcomas range from curable tumors to those causing death via metastasis and recurrence. Thus, there is an urgent need for biomarker identification in order to assess the degree of malignancy, predict prognosis, and evaluate possible therapies. Various proteomic approaches and different clinical materials have been used to this end, and candidate biomarkers have been reported for the different types of sarcomas. However, the sample size used in these biomarker studies was generally insufficient, and thus far, no biomarker has been proved useful in clinics. Given that sarcomas are rare, biomarker validation in this setting is more challenging than in other malignancies. In gastrointestinal stromal tumor, adjuvant therapy has proven to be effective. However, only 40% patients experience metastasis after curative surgery alone, and the rest of the  patients may not need adjuvant therapy. Using a proteomic approach, we identified pfetin (potassium channel tetramerization domain containing 12, KCTD 12) as a novel prognostic biomarker for sarcoma, and immunohistochemically confirmed its clinical usefulness by a multiinstitutional validation study. Here, we describe our experience and discuss the critical points in the discovery of this biomarker.

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[508]

TÍTULO / TITLE:  - Active Targeting to Osteosarcoma Cells and Apoptotic Cell Death Induction by the  Novel Lectin Eucheuma serra Agglutinin Isolated from a Marine Red Alga.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Drug Deliv. 2012;2012:842785. doi: 10.1155/2012/842785. Epub 2012 Dec 27.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/842785

AUTORES / AUTHORS:  - Hayashi K; Walde P; Miyazaki T; Sakayama K; Nakamura A; Kameda K; Masuda S; Umakoshi H; Kato K

INSTITUCIÓN / INSTITUTION:  - Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka 560-8531, Osaka, Japan.

RESUMEN / SUMMARY:  - Previously, we demonstrated that the novel lectin Eucheuma serra agglutinin from  a marine red alga (ESA) induces apoptotic cell death in carcinoma. We now find that ESA induces apoptosis also in the case of sarcoma cells. First, propidium iodide assays with OST cells and LM8 cells showed a decrease in cell viability after addition of ESA. With 50 mug/ml ESA, the viabilities after 24 hours decreased to 54.7 +/- 11.4% in the case of OST cells and to 41.7 +/- 12.3% for LM8 cells. Second, using fluorescently labeled ESA and flow cytometric and fluorescence microscopic measurements, it could be shown that ESA does not bind to cells that were treated with glycosidases, indicating importance of the carbohydrate chains on the surface of the cells for efficient ESA-cell interactions. Third, Span 80 vesicles with surface-bound ESA as active targeting  ligand were shown to display sarcoma cell binding activity, leading to apoptosis  and complete OST cell death after 48 hours at 2 mug/ml ESA. The findings indicate that Span 80 vesicles with surface-bound ESA are a potentially useful drug delivery system not only for the treatment of carcinoma but also for the treatment of osteosarcoma.

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[509]

TÍTULO / TITLE:  - PI3K Inhibition Enhances Doxorubicin-Induced Apoptosis in Sarcoma Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2012;7(12):e52898. doi: 10.1371/journal.pone.0052898. Epub 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0052898

AUTORES / AUTHORS:  - Marklein D; Graab U; Naumann I; Yan T; Ridzewski R; Nitzki F; Rosenberger A; Dittmann K; Wienands J; Wojnowski L; Fulda S; Hahn H

INSTITUCIÓN / INSTITUTION:  - Institute of Human Genetics, University Medical Center, Goettingen, Germany.

RESUMEN / SUMMARY:  - We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy of DOX in several sarcoma cell lines and interacts with DOX in the induction of apoptosis. PI103 decreased the expression of MDR1 and MRP1, which resulted in DOX accumulation. However, the enhancement of DOX-induced apoptosis was unrelated to  DOX accumulation. Neither did it involve inhibition of mTOR. Instead, the combination treatment of DOX plus PI103 activated Bax, the mitochondrial apoptosis pathway, and caspase 3. Caspase 3 activation was also observed in xenografts of sarcoma cells in nude mice upon combination of DOX with the specific PI3K inhibitor GDC-0941. Although the increase in apoptosis did not further impact on tumor growth when compared to the efficient growth inhibition by GDC-0941 alone, these findings suggest that inhibition of PI3K may improve DOX-induced proapoptotic effects in sarcoma. Taken together with similar recent studies of neuroblastoma- and glioblastoma-derived cells, PI3K inhibition seems to be a more general option to sensitize tumor cells to anthracyclines.

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[510]

TÍTULO / TITLE:  - Clinical characters, immunohistochemistry and outcomes of 77patients with skull base chordomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World Neurosurg. 2013 Jan 5. pii: S1878-8750(13)00017-X. doi: 10.1016/j.wneu.2013.01.010.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.wneu.2013.01.010

AUTORES / AUTHORS:  - Ouyang T; Zhang N; Zhang Y; Jiao J; Ren J; Huang T; Chen J

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

RESUMEN / SUMMARY:  - OBJECTIVE: To analyze the clinical characters and immunohistochemistry, treatment outcomes for skull base chordomas and the correlation between extent of resection and pathology type and outcomes. MATERIALS AND METHODS: The clinical materials of 77 consecutive patients with skull base chordomas were analyzed retrospectively.  Follow-up data were available in 66 patients, ranging from 6 to 142 months (mean, 59.6 months). Outcome in survival was assessed by the overall survival (OS) and progression-free survival (PFS) .Outcome in function was evaluated by Karnofshky  Performance Score (KPS). RESULTS: Total or near-total tumor resection was achieved in 25 cases (32.5%), subtotal in 32 cases (47.6%) and partial resection  in 9 cases (11.7%). Gamma knife radiosurgery(GKR) was applied in 22 patients (33.3%). 42 of the 77 patients had immunohistochemistry results and the rates of  positive staining for cytokeratin, epithelial membrane antigen(EMA),vimentin,S-100 were 100%, 92.9%, 83.3%, and 88.1%, respectively. The PFS rates at 3, 5, and 8 years were 82.6%, 45.0%, and 18.2%, respectively. The OS rates at 3, 5 and 8 years were 89.2%, 70.9% and 45.5 %, respectively. Less tumor  resection and dedifferentiated pathology were risk factors for worse OS and PFS (p<0.05). Among the 43 currently surviving patients, the mean KPS before the surgery and at the last follow-up were 87.3and 82.4, respectively. CONCLUSIONS: Aggressive surgical resection should be performed for skull base chordomasconsidering certain postoperative functional status. Immunohistiochemical study is helpful in differential diagnosis. The combination  of aggressive surgical resection and GKR for skull base chordomas maybe obtain favourable outcomes.

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[511]

TÍTULO / TITLE:  - The complex of myxomas, spotty skin pigmentation and endocrine overactivity (Carney complex): imaging findings with clinical and pathological correlation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Insights Imaging. 2013 Jan 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13244-012-0208-6

AUTORES / AUTHORS:  - Courcoutsakis NA; Tatsi C; Patronas NJ; Lee CC; Prassopoulos PK; Stratakis CA

INSTITUCIÓN / INSTITUTION:  - Department of Radiology and Medical Imaging, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, 68100, Greece, ncourcou@med.duth.gr.

RESUMEN / SUMMARY:  - The complex of myxomas, spotty skin pigmentation and endocrine overactivity, or Carney complex (CNC), is a familial multiple endocrine neoplasia and lentiginosis syndrome. CNC is inherited in an autosomal dominant manner and is genetically heterogeneous. Its features overlap those of McCune-Albright syndrome and other multiple endocrine neoplasia (MEN) syndromes. Spotty skin pigmentation is the major clinical manifestation of the syndrome, followed by multicentric heart myxomas, which occur at a young age and are the lethal component of the disease.  Myxomas may also occur on the skin (eyelid, external ear canal and nipple) and the breast. Breast myxomas, when present, are multiple and bilateral among female CNC patients, an entity which is also described as “breast-myxomatosis” and is a  characteristic feature of the syndrome. Affected CNC patients often have tumours  of two or more endocrine glands, including primary pigmented nodular adrenocortical disease (PPNAD), an adrenocorticotropin hormone (ACTH)-independent cause of Cushing’s syndrome, growth hormone (GH)-secreting and prolactin (PRL)-secreting pituitary adenomas, thyroid adenomas or carcinomas, testicular neoplasms (large-cell calcifying Sertoli cell tumours [LCCSCT]) and ovarian lesions (cysts and cancinomas). Additional infrequent but characteristic manifestations of CNC are psammomatous melanotic schwannomas (PMS), breast ductal adenomas (DAs) with tubular features, and osteochondromyxomas or “Carney bone tumour”. Teaching Points * Almost 60 % of the known CNC kindreds have a germline  inactivating mutations in the PRKAR1A gene. * Spotty skin pigmentation is the major clinical manifestation of CNC, followed by heart myxomas. * Indicative imaging signs of PPNAD are contour abnormality and hypodense spots within the gland. * Two breast tumours may present in CNC: myxoid fibroadenomas (breast myxomatosis) and ductal adenomas. * Additional findings of CNC are psammomatous melanotic schwannomas (PMSs) and osteochondromyxomas.

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[512]

TÍTULO / TITLE:  - Diagnostic and therapeutic challenges of a large pleural inflammatory myofibroblastic tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Pulmonol. 2012;2012:102196. doi: 10.1155/2012/102196. Epub 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/102196

AUTORES / AUTHORS:  - Loeffler-Ragg J; Bodner J; Freund M; Steurer M; Uprimny C; Zelger B; Kahler CM

INSTITUCIÓN / INSTITUTION:  - Pneumology/USPH Innsbruck, Department of Internal Medicine VI, Innsbruck Medical  University, Anichstrasse 35, 6020 Innsbruck, Austria.

RESUMEN / SUMMARY:  - We report a 48-year-old woman with a pleural pseudoneoplasm requiring different diagnostic and therapeutic strategies. After initial presentation with increasing dyspnoea, temperature, dry cough, and interscapular pain diagnostic processing showed a large mediastinal mass with marked pleural effusion and high metabolic activity in the 18F-FDG-PET/CT. Extensive CT-guided biopsy of the tumor reaching  from the visceral pleura into the right upper lobe revealed no malignancy, but a  marked inflammatory tissue reaction containing foam cells. Initial empiric antibiotic therapy was temporarily successful. However, in the further course the mass relapsed and was resistant to antibiotics and a corticosteroid trial. With the working hypothesis of an inflammatory myofibroblastic tumor the patient underwent surgical tumor resection, finally confirming the suspected diagnosis. Due to residual disease intravenous immunoglobulins were administered leading to  sustained response. This case with a pleural localisation of a large inflammatory pseudotumor with responsiveness to immunomodulation after incomplete resection extends the reported spectrum of thoracopulmonary manifestations of this rare entity.

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[513]

TÍTULO / TITLE:  - Predictive clinical factors in the diagnosis of gastrointestinal Kaposi’s sarcoma and its endoscopic severity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2012;7(11):e46967. doi: 10.1371/journal.pone.0046967. Epub 2012 Nov 30.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0046967

AUTORES / AUTHORS:  - Nagata N; Shimbo T; Yazaki H; Asayama N; Akiyama J; Teruya K; Igari T; Ohmagari N; Oka S; Uemura N

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology and Hepatology, National Center for Global Health  and Medicine, Tokyo, Japan. nnagata_ncgm@yahoo.co.jp

RESUMEN / SUMMARY:  - BACKGROUND: The diagnosis of gastrointestinal (GI) involvement in Kaposi’s sarcoma (KS) is important to make because the need for treatment depends on the extent of the disease. Moreover, severe GI lesions can cause serious complications. Endoscopy with biopsy is an extremely useful method to diagnose GI-KS. However, determining the indications for endoscopy is difficult because KS can occur without GI symptoms or cutaneous KS. This study sought to clarify predictive clinical factors for GI-KS and its severity on endoscopy. METHODOLOGY/PRINCIPAL FINDINGS: A total of 1,027 HIV-infected patients who underwent endoscopy were analyzed. Sexual behavior, CD4 count, HIV RNA, history of highly active antiretroviral therapy (HAART), GI symptoms, and cutaneous KS were assessed. Endoscopic severity including bulky tumor, ulceration, and number  of lesions were evaluated. Thirty-three patients had GI-KS and 46 patients cutaneous KS. Among the GI-KS patients, 78.8% (26/33) had no GI symptoms and 24.2% (8/33) had no cutaneous KS. Univariate analysis identified men who have sex with men (MSM), CD4 <100 cells/microL, HIV RNA >/=10,000 copies/mL, no history of HAART, and cutaneous KS were significantly associated with GI-KS. Among these factors, cutaneous KS was closely related to GI-KS on multivariable analysis. Among patients without cutaneous KS, MSM and CD4 count <100 cells/microL were the only independent clinical factors related to GI-KS. Bulky tumor was significantly associated with CD4 <100 cells/microL and large number of lesions was significantly associated with HIV-RNA >/=10,000 copies/mL. CONCLUSIONS: To diagnose GI-KS, clinical factors need to be considered before endoscopy. The presence of GI symptoms is not useful in predicting GI-KS. MSM and CD4 count <100 cells/microL are predictive factors among patients without cutaneous KS. Caution  should be exercised especially in patients with low CD4 counts or high HIV viral  loads as they are more likely to develop severe GI-KS lesions.

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[514]

TÍTULO / TITLE:  - Vaginal leiomyoma in pregnancy presenting as a prolapsed vaginal mass.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hong Kong Med J. 2012 Dec;18(6):533-5.

AUTORES / AUTHORS:  - Dane C; Rustemoglu Y; Kiray M; Ozkuvanci U; Tatar Z; Dane B

INSTITUCIÓN / INSTITUTION:  - Department of Gynecology and Obstetrics, Haseki Training and Research Hospital, Istanbul, Turkey. cemdane@yahoo.com

RESUMEN / SUMMARY:  - Vaginal leiomyomas are rare benign solid tumours of the vagina. They can cause mechanical dystocia, which is a common problem in obstetrics leading to serious maternal and perinatal complications. Here we describe a patient with a vaginal leiomyoma diagnosed during the mid-trimester that could have caused dystocia. This 22-year-old woman presented with a vaginal mass and leaking vaginal fluid during pregnancy. On examination, a prolapsed, pedunculated mass, measuring 5 x 3 x 4 cm was detected in the anterior vaginal wall. Via a midline incision, the mass was easily enucleated and removed. Transvaginal surgical enucleation of the  vaginal leiomyoma is usually curative and recommended as the initial treatment of choice to prevent for dystocia. Such treatment is indicated when the tumour is a  potential obstacle to normal labour.

 

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[515]

TÍTULO / TITLE:  - Sudden death as presenting symptom caused by cardiac primary multicentric left ventricle rhabdomyoma, in an 11-month-old baby. An immunohistochemical study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2012 Dec 3;7:169. doi: 10.1186/1746-1596-7-169.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-7-169

AUTORES / AUTHORS:  - Neri M; Di Donato S; Maglietta R; Pomara C; Riezzo I; Turillazzi E; Fineschi V

INSTITUCIÓN / INSTITUTION:  - Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D’Avanzo, Via degli Aviatori 1, Foggia, 71100, Italy.

RESUMEN / SUMMARY:  - This case report describes a sudden cardiac death in an apparent healthy 11-month-old infant caused by a multifocal cardiac rhabdomyoma. Parents reported  that a few days before the child had fallen to the ground getting a little superficial injury to the scalp. The authors hypothesize that it may have been a  transient loss of consciousness episode caused by the cardiac tumour. After the gross examination, histological investigation supported by immunohistochemical analysis using antibody anti-Myoglobin, Actin, Vimentin, Desmin, CD34, S-100, Ki-67 was carried out for the diagnosis. Death was attributed to a multifocal cardiac rhabdomyoma, a benign tumour of striated muscle, which has been completely asymptomatic. In particular, one mass filled the entire posterior wall of the left ventricle. The insidious development of benign cardiac tumours also in infants and children is outlined, focusing on the responsible mechanisms of sudden death in such cases and providing a reference for additional study on these subjects. Virtual slides: The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/7163626988365078.

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[516]

TÍTULO / TITLE:  - Undifferentiated pleomorphic sarcoma with osteoclast-like giant cells of the female breast.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Jan 26;11(1):21.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-21

AUTORES / AUTHORS:  - Balbi G; Martino L; Pitruzzella G; Pitruzzella D; Grauso F; Napolitano A; Seguino E; Gioia F; Orabona P

RESUMEN / SUMMARY:  - ABSTRACT: The authors describe a case of undifferentiated pleomorphic sarcoma of  the breast occurring in a 50-year-old woman who presented with a palpable mass in her right breast. She first noticed the mass one month previously. Core needle biopsy showed connective tissue including epithelioid and spindle cells. The patient underwent total mastectomy without axillary lymph node dissection. Based  on examination of the excised tumor, the initial pathologic diagnosis was atypical spindle-shaped and ovoid cells with uncertain malignant potential. Histological findings with immunomarkers led to the final diagnosis of undifferentiated pleomorphic sarcoma.This case highlights a rare and interesting  variant of primary breast sarcoma and the important role of immunohistochemistry  in defining histological type and differential diagnosis. Hence, undifferentiated pleomorphic sarcoma has been a diagnosis of exclusion performed through sampling  and critical use of ancillary diagnostic techniques.

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[517]

TÍTULO / TITLE:  - Choosing a surgical corridor for skull base chordoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neurol India. 2012 Nov-Dec;60(6):567-9. doi: 10.4103/0028-3886.105187.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0028-3886.105187

AUTORES / AUTHORS:  - Muthukumar N

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Madurai Medical College, Madurai, India.

 

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[518]

TÍTULO / TITLE:  - Systemic analysis of gene expression profiles identifies ErbB3 as a potential drug target in pediatric alveolar rhabdomyosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2012;7(12):e50819. doi: 10.1371/journal.pone.0050819. Epub 2012 Dec 5.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0050819

AUTORES / AUTHORS:  - Nordberg J; Mpindi JP; Iljin K; Pulliainen AT; Kallajoki M; Kallioniemi O; Elenius K; Elenius V

INSTITUCIÓN / INSTITUTION:  - Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.

RESUMEN / SUMMARY:  - Pediatric sarcomas, including rhabdomyosarcomas, Ewing’s sarcoma, and osteosarcoma, are aggressive tumors with poor survival rates. To overcome problems associated with nonselectivity of the current therapeutic approaches, targeted therapeutics have been developed. Currently, an increasing number of such drugs are used for treating malignancies of adult patients but little is known about their effects in pediatric patients. We analyzed expression of 24 clinically approved target genes in a wide variety of pediatric normal and malignant tissues using a novel high-throughput systems biology approach. Analysis of the Genesapiens database of human transcriptomes demonstrated statistically significant up-regulation of VEGFC and EPHA2 in Ewing’s sarcoma, and ERBB3 in alveolar rhabdomyosarcomas. In silico data for ERBB3 was validated by demonstrating ErbB3 protein expression in pediatric rhabdomyosarcoma in vitro  and in vivo. ERBB3 overexpression promoted whereas ERBB3-targeted siRNA suppressed rhabdomyosarcoma cell gowth, indicating a functional role for ErbB3 signaling in rhabdomyosarcoma. These data suggest that drugs targeting ErbB3, EphA2 or VEGF-C could be further tested as therapeutic targets for pediatric sarcomas.

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[519]

TÍTULO / TITLE:  - Treatment Results of Small Intestinal Gastrointestinal Stromal Tumors Less than 10 cm in Diameter: A Comparison between Laparoscopy and Open Surgery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastric Cancer. 2012 Dec;12(4):243-8. doi: 10.5230/jgc.2012.12.4.243. Epub 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 5230/jgc.2012.12.4.243

AUTORES / AUTHORS:  - Ihn K; Hyung WJ; Kim HI; An JY; Kim JW; Cheong JH; Yoon DS; Choi SH; Noh SH

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

RESUMEN / SUMMARY:  - PURPOSE: To evaluate the technical feasibility and oncologic safety, we assessed  the short-term and long-term outcomes of laparoscopic resection of the small bowel gastrointestinal stromal tumors smaller than 5 cm by comparing those of open surgery by subgroup analysis based on tumor size. MATERIALS AND METHODS: From November 1993 to January 2011, 41 laparoscopic resections were performed among the 95 patients who underwent resection of small intestine </=10 cm in diameter. The clinicopathologic features, perioperative outcomes, recurrences and survival of these patients were reviewed. RESULTS: The postoperative morbidity rates were comparable between the 2 groups. Laparoscopic surgery group showed significantly shorter operative time (P=0.004) and duration of postoperative hospital stay (P<0.001) than open surgery group and it was more apparent in the smaller tumor size group. There were no difference in 5-year survival for the laparoscopic surgery versus open surgery groups (P=0.163), and in 5-year recurrence-free survival (P=0.262). The subgroup analysis by 5 cm in tumor size also shows no remarkable differences in 5-year survival and recurrence-free survival. CONCLUSIONS: Laparoscopic resection for small bowel gastrointestinal stromal tumors of size less than 10 cm has favorable short-term postoperative outcomes, while achieving comparable oncologic results compared with open surgery. Thus, laparoscopic approach can be recommended as a treatment modality for patients with small bowel gastrointestinal stromal tumors less than 10 cm in  diameter.

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[520]

TÍTULO / TITLE:  - Endometrial proliferative lesions associated with uterine fibromatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Rom J Morphol Embryol. 2012;53(3 Suppl):743-7.

AUTORES / AUTHORS:  - Braila AD; Vaniova Klimentova D; Damian CM; Braila MB

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 2-4 Petru Rares Street, Craiova, Romania. ancabraila@yahoo.com

RESUMEN / SUMMARY:  - Hysteroscopy and uterine curettage are required in cases of atypical hyperplasia  in premenopause and in all cases of hyperplasia with/without atypia in postmenopausal women. Biopsic curettage is the method of choice in the diagnosis  of endometrial pathology. Transvaginal ultrasound and Doppler examination are useful in assessing the risk of endometrial hyperplasia or endometrial cancer in  postmenopausal women without/with continuous replacement therapy, but cannot replace endometrial biopsy to exclude endometrial cancer diagnosis. Medical treatment with progesterone containing drugs addresses endometrial hyperplasia without atypia. Surgical treatment is recommended for premenopausal and postmenopausal patients with uterine fibromatosis associated with atypical hyperplasia as well as patients with adenocarcinoma. Risk of progression to malignancy requires clinical and histopathological monitoring to avoid insufficient treatment of lesions with evolutive risk and aggressive treatment of lesions without risk.

 

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[521]

TÍTULO / TITLE:  - High-resolution three-dimensional echocardiography of left atrial myxoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asian Cardiovasc Thorac Ann. 2012 Dec;20(6):741. doi: 10.1177/0218492311435928.

            ●● Enlace al texto completo (gratuito o de pago) 1177/0218492311435928

AUTORES / AUTHORS:  - Inderbitzin DT; Seeberger M; Grapow M; Kaiser C; Muralidhar K; Eckstein FS

INSTITUCIÓN / INSTITUTION:  - devdasinderbitzin@bluewin.ch.

 

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[522]

TÍTULO / TITLE:  - Primary inferior vena cava leiomyosarcoma: reconstruction is not mandatory.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asian Cardiovasc Thorac Ann. 2012 Dec;20(6):715-7. doi: 10.1177/0218492312440266.

            ●● Enlace al texto completo (gratuito o de pago) 1177/0218492312440266

AUTORES / AUTHORS:  - Rodriguez-Caulo EA; Velazquez C; Ramirez B; Barquero JM

INSTITUCIÓN / INSTITUTION:  - erodriguezcaulo@hotmail.com.

RESUMEN / SUMMARY:  - Computed tomography in an 81-year-old woman revealed obstruction of the inferior  vena cava by a large primary vascular leiomyosarcoma, and involvement of the right renal vein. She underwent successful en-bloc resection of the tumor, right  kidney, hepatic segments IV and VI, and inferior vena cava, without caval reconstruction. A renal vein-to-remaining infrahepatic inferior vena cava saphenous vein graft bypass was performed for left renal venous drainage. The need for vascular reconstruction is not always mandatory.

 

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[523]

TÍTULO / TITLE:  - A huge intrathoracic fibromatosis with rapid aggression.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chin Med J (Engl). 2012 Dec;125(24):4530-2.

AUTORES / AUTHORS:  - Chen JH; Jin EH; Chen GY

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

 

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[524]

TÍTULO / TITLE:  - Angiosarcoma of small bowel presenting with obstruction: novel observations on a  rare diagnostic entity with unique clinical presentation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Gastrointest Med. 2012;2012:480135. doi: 10.1155/2012/480135. Epub 2012  Oct 21.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/480135

AUTORES / AUTHORS:  - Siderits R; Poblete F; Saraiya B; Rimmer C; Hazra A; Aye L

INSTITUCIÓN / INSTITUTION:  - Robert Wood Johnson University Medical School, Piscataway, NJ 08854, USA.

RESUMEN / SUMMARY:  - We present a case of angiosarcoma in small bowel, presenting with partial small bowel obstruction in a 79-year-old man with no history of radiation, chemotherapy, toxin exposure, or previous operative intervention. Angiosarcoma of small bowel is a rare entity which may present with nausea, abdominal pain, recurrent bleeding, and usually a history of prior radiation or exposure to specific toxins (polyvinyl chloride). Angiosarcoma of small bowel tends to spread rapidly and has a poor prognosis. We review the surgical and oncologic challenges. We report unique macroscopic findings of raised hyperemic margins, which are suggestive of a vasogenic lesion and the histologic feature of a partially retiform pattern with dense basement membrane material in an otherwise  poorly differentiated lesion.

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[525]

TÍTULO / TITLE:  - Two cases of cutaneous angiosarcoma developed after breast cancer surgery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Dermatol. 2012 Sep;4(3):247-9. doi: 10.1159/000345559. Epub 2012 Sep 14.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000345559

AUTORES / AUTHORS:  - Iga N; Endo Y; Fujisawa A; Matsumura Y; Kabashima K; Tanioka M; Miyachi Y

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

RESUMEN / SUMMARY:  - Several randomized trials have shown that breast-conserving therapy (BCT) is as effective as mastectomy and should be a standard treatment for early-stage breast cancer. Recently, there has been an increase in reports of angiosarcoma (AS) after BCT. Herein, we report a case of AS which developed after BCT and a case of Stewart-Treves syndrome with a focus on lymphedema. Chronic lymphedema is the primary risk factor for AS, which was first described in 1948 by Stewart and Treves [Cancer 1948;1:64-81]. Radiation therapy secondarily tends to induce the development of AS, since radiation therapy induces fibrosis and proliferation of  lymphatic vessels via cytokines such as vascular endothelial growth factor, which is followed by subclinical chronic edema. It is suggested that axillary lymph node dissection predisposes patients to the development of AS, since it is closely associated with lymphedema. Breast surgeons and radiologists should be aware of skin changes in order to improve the early detection of AS during the follow-up of patients who have undergone BCT, and especially those treated with axillary lymph node dissection.

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[526]

TÍTULO / TITLE:  - Right atrial myxoma as a possible cause of hemorrhagic stroke and sudden death.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Niger Med J. 2012 Apr;53(2):102-4. doi: 10.4103/0300-1652.103551.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0300-1652.103551

AUTORES / AUTHORS:  - Sabageh D; Odujoko OO; Komolafe AO

INSTITUCIÓN / INSTITUTION:  - Department of Morbid Anatomy and Histopathology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.

RESUMEN / SUMMARY:  - Right atrial myxomas are rare primary tumors of the heart. They may remain asymptomatic or eventually cause constitutional signs and symptoms. Less frequently, obstruction of the tricuspid valve occurs, resulting in exertional dyspnea, syncope, or sudden death. Neurological manifestation as initial presentation of atrial myxomas is rarely, if ever, associated with right atrial myxomas and may be secondary to cerebral infarction, cerebral hemorrhage and, more rarely subarachnoid hemorrhage. We review the case of a previously unknown,  middle-aged Nigerian man who presented to hospital with severe headache and sudden loss of consciousness. A clinical diagnosis of hypertensive hemorrhagic cerebrovascular accident was made. The patient died suddenly a few hours after presentation. Post-mortem examination revealed a small intracerebral hemorrhage in the left superior temporal lobe as well as a large right atrial myxoma, a ventricular septal defect in the muscular septum, and right ventricular hypertrophy. The liver showed fatty change while the kidneys showed evidence of benign nephrosclerosis. Right atrial myxomas may, therefore, be remotely considered as a cause of intracranial hemorrhage, especially in the presence of predisposing cardiac anomalies such as a ventricular septal defect. Similarly, being a known cause of right heart failure, sudden death, and other constitutional derangements, it may contribute significantly to disease outcome.  Hence, it should be given due consideration in the differential diagnosis of cerebrovascular accidents.

 

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[527]

TÍTULO / TITLE:  - Giant colonic lipoma presenting with intermittent intestinal obstruction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Coll Physicians Surg Pak. 2012 Dec;22(12):792-3. doi: 12.2012/JCPSP.792793.

AUTORES / AUTHORS:  - Ullah S; Ahmed H; Jehangir E

INSTITUCIÓN / INSTITUTION:  - Department of Coloproctology, West Cumberland Hospital, Whitehaven, Post code: CA28 8JG, UK. drsanavri@hotmail.com

RESUMEN / SUMMARY:  - Lipomas of gastrointestinal (GI) tract are the common benign tumours. They are usually small and asymptomatic; however, large colonic lipoma is a rare tumour and may cause intestinal obstruction. A similar rare case of large lipoma, treated with laparoscopic right hemicolectomy, is reported here.

 

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[528]

TÍTULO / TITLE:  - Primary tracheal angiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asian Cardiovasc Thorac Ann. 2012 Dec;20(6):742. doi: 10.1177/0218492312445587.

            ●● Enlace al texto completo (gratuito o de pago) 1177/0218492312445587

AUTORES / AUTHORS:  - Quiroga J; Garcia-Prim JM; Rivo E; Moldes M

INSTITUCIÓN / INSTITUTION:  - quirojo@hotmail.com.

 

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[529]

TÍTULO / TITLE:  - Leiomyomatosis peritonealis disseminata in a Nigerian woman.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Niger Med J. 2012 Jul;53(3):172-4. doi: 10.4103/0300-1652.104390.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0300-1652.104390

AUTORES / AUTHORS:  - Dim CC; Akogu SP; Ezegwui HU; Olusina DB

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria.

RESUMEN / SUMMARY:  - Leiomyomatosis peritonealis disseminata (LPD) is a rare condition. A 48-year-old  multiparous woman was referred because of an incidental ultrasound finding suggestive of LPD. She had a 6-year past history of use of combined oral contraceptive pills. LPD was also suspected at laparotomy and confirmed by histology. She had total abdominal hysterectomy, bilateral salpingo ophorectomy and infracolic omentectomy. Patient was being followed-up. LSD is a rare gynecological condition which can pose a diagnostic challenge. Removal of estrogen sources as was done for the patient is the mainstay of treatment. Patient follow-up is very important because of the risk of malignant transformation.

 

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[530]

TÍTULO / TITLE:  - A rare presentation of cardiac myxoma: left ventricular outflow cyst.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asian Cardiovasc Thorac Ann. 2012 Dec;20(6):739. doi: 10.1177/0218492311435929.

            ●● Enlace al texto completo (gratuito o de pago) 1177/0218492311435929

AUTORES / AUTHORS:  - Elmistekawy EM; Alatafy AA; Ahmed K; Hammad AA

INSTITUCIÓN / INSTITUTION:  - Elmistekawy@yahoo.com.

 

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[531]

TÍTULO / TITLE:  - Neglected Giant Fibroadenoma of the Breast presenting like a Fungating Breast Cancer in a Premenarchal Nigerian Teenager.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - West Afr J Med. 2012 Jul-Aug;31(3):211-3.

AUTORES / AUTHORS:  - Arowolo OA; Akinkuolie AA; Adisa AO; Obonna GC; Olasode BJ

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile Ife , 220005 Osun State.

RESUMEN / SUMMARY:  - Background: Giant fibroadenoma of the breast is a type of rare benign breast tumour which can grow to a giant size, It is even rarer for this benign tumour to grow rapidly, ulcerate spontaneously and present like a fungating breast tumour in a way mimicking breast cancer. Carcinoma of the breast on the other hand has been on the increase so much that it has assumed an epidemiological dimension. In developing country such as Nigeria late presentation of breast cancer has remained a rule rather than exception and it is very common for patient to present with fungating breast lesion. Study Design: This is a case presentation of a 14 year old premenarchal girl presenting with a massive ulcerating and fungating left breast mass that was initially thought to be a fungating locally advanced breast carcinoma on clinical examination. Further examination of the morphology of the resected surgical specimen and histological examination confirmed it to be giant fibroadenoma of the breast. ResultS: The giant fungating breast tumour successfully managed by partial mastectomy and breast reconstruction with an excellent result and a high degree of patient satisfaction was achieved. Conclusion: Though a rare clinical entity benign breast tumour can  present like a fungating breast cancer and this must be bore in mind especially in young adolescent patients presenting with ulcerating breast tumour.

 

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[532]

TÍTULO / TITLE:  - Multiple metastatic basal cell carcinoma with concurrent metastatic pleomorphic sarcoma in chronic lymphedema area—case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - An Bras Dermatol. 2012 Nov-Dec;87(6):899-902.

AUTORES / AUTHORS:  - Oliveira Gda P; Girao RJ; Soares CT; Mello Junior EJ

INSTITUCIÓN / INSTITUTION:  - Federal University of Piaui (Universidade Federal do Piaui - UFPI) - Teresina (PI), Brazil. giulianooliveira@hotmail.com

RESUMEN / SUMMARY:  - Chronic lymphedema presents as interstitial fluid retention due to a failure in the lymphatic system drainage. The affected region becomes more vulnerable immunologically and predisposed to the onset of neoplasms. Basal Cell Carcinoma is the most common sort of neoplasm, nevertheless it rarely metastisizes. Sarcomas are malignant mesenchymal neoplasms, locally aggressive, which can spread. Here is reported an infrequent case of multiple basal cell carcinoma, synchronous to a poorly differentiated pleomorphic sarcoma, both spreading to lymph nodes and arising from tissue compromised by chronic lymphedema.

 

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[533]

TÍTULO / TITLE:  - Colonic inflammatory myofibroblastic tumours: an institutional review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Colorectal Dis. 2013 Jan 26. doi: 10.1111/codi.12149.

            ●● Enlace al texto completo (gratuito o de pago) 1111/codi.12149

AUTORES / AUTHORS:  - Kumar GR; Evaldas SN; Sudeep S; Lal SP; Upadhyaya KS

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Gastrointestinal unit, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

RESUMEN / SUMMARY:  - AIM: The aim of the study was to present the largest series of colonic inflammatory myofibroblastic tumour (C-IMFT) in the literature so far and to provide a review of this condition. METHOD: A retrospective review was carried out of a consecutive series of patients diagnosed at a community-based hospital with a specialized gastro-intestinal unit with a C-IMFT between 2002 and 2011. The main outcome measures were success rate and postoperative complications. Using a set of terms we searched the databases Pub Med for articles published on  C-IMFT. We reviewed the data from these studies and case reports. RESULTS: There  were seven patients with a histopathologically proven C-IMFT. The patients’ mean  age was 39+/-11.3 years. Four presented with clinical features of intestinal obstruction of varying severity and three with symptoms of anaemia. Complete surgical resection with end-to-end anastomosis was performed. The gross morphology included polypoidal myxoid tumours that served as a lead point for intussusception in two cases, a whorled mass in two and a circumferential infiltrative tumour in three. Microscopically, all tumours had typical features of IMFT with a variable expression of ALK-1 and tumour-free resection margins. All patients were well, without local recurrence or metastasis at a mean follow-up of 46.8+/-11.9 months. CONCLUSION: Surgical resection is effective for  this rare tumour which mostly behaves in a benign manner. Our review supports the need for patients to be followed up for long periods because of the possibility of metastasis or late recurrence. © 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.

 

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[534]

TÍTULO / TITLE:  - Malignant fibrous histiocytoma originating from right ventricular outflow tract.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asian Cardiovasc Thorac Ann. 2012 Dec;20(6):702-4. doi: 10.1177/0218492312440806.

            ●● Enlace al texto completo (gratuito o de pago) 1177/0218492312440806

AUTORES / AUTHORS:  - Tamenishi A; Matsumura Y; Okamoto H

INSTITUCIÓN / INSTITUTION:  - tamenishi89@yokkaichihp01.jp.

RESUMEN / SUMMARY:  - A 70-year-old man presented with right heart failure due to obstruction of the right ventricular outflow tract by a large tumor mass. The tumor was surgically resected as much as possible. Neither chemotherapy nor radiotherapy was given. The patient died of local recurrence and multiple lung metastases 6 months after  surgery. The prognosis of this very rare primary cardiac tumor is generally poor.

 

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[535]

TÍTULO / TITLE:  - Role of Endocrine Disrupting Chemicals in the Occurrence of Benign Uterine Leiomyomata: Special Emphasis on AhR Tissue Levels.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asian Pac J Cancer Prev. 2012;13(11):5445-50.

AUTORES / AUTHORS:  - Bidgoli SA; Khorasani H; Keihan H; Sadeghipour A; Mehdizadeh A

INSTITUCIÓN / INSTITUTION:  - Department of Toxicology and Pharmacology, Islamic Azad University, Pharmaceutical Sciences Branch (IAUPS), Tehran, Iran E-mail arbabi.s@iaups.ac.ir, sepideharbabi@yahoo.com.

RESUMEN / SUMMARY:  - Although benign uterine leiomyomata (LMA) is the most common reproductive tumor in premenopausal women, its etiology is largely unknown. We aimed in the present  study to demonstrate the potential role of environmental factors with estrogenic  activity in tumor etiology by focusing on the role of aryl hydrocarbon receptor (AhR) which mediates the effects of many environmental endocrine disruptors and contributes to the loss of normal ovarian function in polluted environments. This case-control study aimed to compare the interactions between AhR and lifestyle factors in a clinical setting for the first time among 138 newly diagnosed LMA patients and 138 normal controls who lived in Tehran and Mashhad, respectively, during the last 10 years. To conduct immunohistochemical studies using appropriate monoclonal antibodies, 30 cases were selected retrospectively from 2009-2011 from the pathology departments of two university hospitals in Tehran. Although the levels of sex steroid receptors were similar in adjacent myometrium  and uterine leiomyomas of all cases, AhR was significantly overexpressed (p=0.034, OR=1.667) in uterine LMA and this overexpression was correlated with living in Tehran [(p=0.04, OR=16 (1.216-210.58)], smoking[P=0.04, OR=2.085 (1.29-3.371)], living near polycyclic aromative hydrocarbon producing companies [p=0.007, OR=2.22 (1.256-3.926)] and eating grilled meat [p=0.042, OR=1.28 (1.92-3.842)]. Our study contributes to the understanding of the effects of EDCs  on AhR levels as well as women’s health and points out possible risk factors for  the development and growth of uterine LMA. It seems that the development of LMA could be the result of interactions between hormonal and environmental factors.

 

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[536]

TÍTULO / TITLE:  - Mezenchymal (Non-epithelial) “Non-GIST” Tumors of the Digestive Tract.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chirurgia (Bucur). 2012 Nov-Dec;107(6):742-50.

AUTORES / AUTHORS:  - Diaconescu MR; Diaconescu S

RESUMEN / SUMMARY:  - Morphological, immunohistochemical and ultrastructural but also clinical and prognostic differences between multiple types of mesenchimal (stromal, nonepithelial) tumors of the gastrointestinal tract prompted us the remembrance of an anecdotic series of sixteen observations of mesenchymal “nonstromal” gastrointestinal tumors (MNSGIT) encountered in four decades of surgical practice. The diagnosis was mainly established on clinical grounds (dyspepsia, pains, digestive hemorrhage or obstruction, palpable tumor) - some lesions being  incidentally discovered - and confirmed by radiology, endoscopy, intraoperative exploration and microscopic pathology examination which revealed 9 schwannomas, three leiomyomas, two lipomas, fibroma and “mixoma” one case each. Our cases were located on the stomach (n=12), small bowell (n=1) and right colon (n=3). All the  cases were operated on being practiced tumor exeresis with mucous or parietal ruff excision, atypical, conservative and standard (segmentar or sectorial) visceral resection. There was no postoperative morbidity or mortality in our series. Median follow-up for our cases was 24 (range 6 - 60) months and there are not evidence of recurrences or metastatic disease. Even if the actual concerns are prioritary oriented towards the study of GIST, the current nosology of the tiny subgroup of mesenchymal (non-epithelial) “non-GIST” lesions of the digestive tract must be reloaded helping the practioner which can be confronted with this pathology to a better evaluation and optimal therapy.

 

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[537]

TÍTULO / TITLE:  - Osteoblastoma in the region of the hip.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Chin Med Assoc. 2013 Feb;76(2):115-20. doi: 10.1016/j.jcma.2011.10.014. Epub 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jcma.2011.10.014

AUTORES / AUTHORS:  - Yang CY; Chen CF; Chen WM; Wu PK; Lee FT; Chen PC; Liu CL; Chen TH

INSTITUCIÓN / INSTITUTION:  - Therapeutical and Research Center of Musculoskeletal Tumor, Department of Orthopedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Orthopedics, Kuang-Tien General Hospital, Taichung, Taiwan, ROC; Department of Surgery, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC; Hungkuang University, Taichung, Taiwan, ROC.

RESUMEN / SUMMARY:  - Osteoblastoma occurring in the region of the hip is very rare, and vague symptoms with uncharacteristic radiographic features often lead to misdiagnosis. Because of radiographic and histological similarities, it must be carefully distinguished from osteoid osteoma, aneurysmal bone cyst, giant cell tumor, and osteosarcoma. Computed tomography is the preferred imaging modality as it is able to detect the nidus and images will not exhibit the flare phenomenon caused by surrounding inflammation seen with magnetic resonance imaging. For hip joint lesions in weight-bearing areas, intralesional curettage may achieve satisfactory outcomes as compared with wide resection. We herein report two cases of osteoblastoma in the hip region in which diagnosis was delayed that were successfully treated with curettage and followed by high-speed burring.

 

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[538]

TÍTULO / TITLE:  - Giant inflammatory fibroid polyp.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Rom J Intern Med. 2012 Apr-Jun;50(2):179-85.

AUTORES / AUTHORS:  - Tudose I; Andrei F; Calu V; Staniceanu F; Miron A

INSTITUCIÓN / INSTITUTION:  - Pathology Department, “Elias” Emergency Hospital, Bucharest, Romania. irina_tds@yahoo.com

RESUMEN / SUMMARY:  - Inflammatory fibroid polyps are uncommon but well documented polypoid lesions occurring in gastrointestinal tract, most commonly in the stomach followed by ileum and rarely in the colon, duodenum or esophagus, especially in the sixth decade of life. The lesions are characterized by variable proliferation of fibroblasts and small vessels which may involve the whole thickness of the digestive wall, in an edematous connective tissue accompanying a marked inflammatory cell infiltrate which contains numerous eosinophils. We present the  case of a 33 years old male patient with a solid, cylindrical-shaped 11/6.5/5 cm  tumor arising from the inferior 1/3rd of the esophagus and eso-gastric region, projecting into the lumen of the stomach. The morphological features and the immnunohistochemical profile were consistent with the diagnosis of IFP. This case has peculiar clinical and pathological particularities (sex and age of the patient, location and large dimensions of the lesion) that should be kept in mind when evaluating a mesenchymal tumor of the eso-gastric junction.

 

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[539]

TÍTULO / TITLE:  - Pancreatic extragastrointestinal stromal tumors, interstitial cajal like cells, and telocytes.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JOP. 2013 Jan 10;14(1):1-14. doi: 10.6092/1590-8577/1293.

AUTORES / AUTHORS:  - Padhi S; Sarangi R; Mallick S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Pondicherry Institute of Medical Sciences. Ganapathychettykulam, Kalapet, Puducherry, India. somanath.padhi@gmail.com.

RESUMEN / SUMMARY:  - CONTEXT: The discovery and subsequent ultrastructural characterization of the interstitial Cajal like cells (now called telocytes) in virtually every anatomic  sites of the human body, by Laurentiu M Popescu and co-workers, have dramatically improved the understanding the function of these cells and pathogenesis of extragastrointestinal stromal tumors (EGIST). Pancreatic extragastrointestinal stromal tumors (pEGIST), phenotypically similar to pancreatic interstitial Cajal  like cells, are extremely rare with an unpredictable biological behavior. OBJECTIVE: To review the clinicopathological, radiological, immunohistochemical,  and therapeutic outcome data of all reported cases of pEGIST, and highlight the developments in the field of pancreatic interstitial Cajal like cells/telocytes.  METHODS: A systematic review of English literature (January 2000 to July 2012) was done by using the search engine of PubMed, PubMed Central, Google Scholar, and the Directory of Open Access Journals. RESULTS: There have been 19 reported cases of pEGIST during the last decade, over an age range of 31 to 84 years (mean: 56 years) with equal gender predilection ((male:female ratio: 9:10). Preoperative radiological characteristics have been mostly nondiagnostic though these were used, in some, for tissue diagnosis. Majority of pEGIST were localized to pancreatic head (8/19, 42.1%), and 15 of 19 patients (78.9%) were symptomatic  at first presentation. The mean size ranged from 2.5 to 35cm (mean: 14 cm). Histomorphological features were that of predominantly spindle cell tumor which consistently expressed c-KIT/CD117 and CD34 by immunohistochemistry, making these two as the most sensitive markers at this site. RESULTS: from studies involving discovery on gastrointestinal stromal tumor 1 (DOG-1), the most specific biomarker of GIST/EGIST, has been inconclusive and this was found to be positive  in one case only. Neoadjuvant chemotherapy with imatinib mesylate and sunitinib were used in few cases, and genetic analysis of c-KIT proto-oncogene was done in  two. By univariate analysis, none of the clinicopathological parameters, except surgical resection with microscopic free margin (R0 resection) (P&lt;0.05), were  found to be an important indicators of outcome. CONCLUSION: The biological behavior of pEGIST, at present, seems unpredictable which requires indefinite period of follow-up. Large number of such cases with genetic analysis supplemented with immunohistochemistry studies will hopefully throw more light in these tumors.

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[540]

TÍTULO / TITLE:  - TNF-alpha and Tumor Lysate Promote the Maturation of Dendritic Cells for Immunotherapy for Advanced Malignant Bone and Soft Tissue Tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2012;7(12):e52926. doi: 10.1371/journal.pone.0052926. Epub 2012 Dec 21.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0052926

AUTORES / AUTHORS:  - Miwa S; Nishida H; Tanzawa Y; Takata M; Takeuchi A; Yamamoto N; Shirai T; Hayashi K; Kimura H; Igarashi K; Mizukoshi E; Nakamoto Y; Kaneko S; Tsuchiya H

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.

RESUMEN / SUMMARY:  - BACKGROUND: Dendritic cells (DCs) play a pivotal role in the immune system. There are many reports concerning DC-based immunotherapy. The differentiation and maturation of DCs is a critical part of DC-based immunotherapy. We investigated the differentiation and maturation of DCs in response to various stimuli. METHODS: Thirty-one patients with malignant bone and soft tissue tumors were enrolled in this study. All the patients had metastatic tumors and/or recurrent tumors. Peripheral blood mononuclear cells (PBMCs) were suspended in media containing interleukin-4 (IL-4) and granulocyte-macrophage colony stimulating factor (GM-CSF). These cells were then treated with or without 1) tumor lysate (TL), 2) TL + TNF-alpha, 3) OK-432. The generated DCs were mixed and injected in  the inguinal or axillary region. Treatment courses were performed every week and  repeated 6 times. A portion of the cells were analyzed by flow cytometry to determine the degree of differentiation and maturation of the DCs. Serum IFN-gamma and serum IL-12 were measured in order to determine the immune response following the DC-based immunotherapy. RESULTS: Approximately 50% of PBMCs differentiated into DCs. Maturation of the lysate-pulsed DCs was slightly increased. Maturation of the TL/TNF-alpha-pulsed DCs was increased, commensurate  with OK-432-pulsed DCs. Serum IFN-gamma and serum IL-12 showed significant elevation at one and three months after DC-based immunotherapy. CONCLUSIONS: Although TL-pulsed DCs exhibit tumor specific immunity, TL-pulsed cells showed low levels of maturation. Conversely, the TL/TNF-alpha-pulsed DCs showed remarkable maturation. The combination of IL-4/GM-CSF/TL/TNF-alpha resulted in the greatest differentiation and maturation for DC-based immunotherapy for patients with bone and soft tissue tumors.

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[541]

TÍTULO / TITLE:  - Greater scaffold permeability promotes growth of osteoblastic cells in a perfused bioreactor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Tissue Eng Regen Med. 2013 Jan 24. doi: 10.1002/term.1701.

            ●● Enlace al texto completo (gratuito o de pago) 1002/term.1701

AUTORES / AUTHORS:  - Fan J; Jia X; Huang Y; Fu BM; Fan Y

INSTITUCIÓN / INSTITUTION:  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.

RESUMEN / SUMMARY:  - Pore size and porosity have been widely acknowledged as important structural factors in tissue-engineered scaffolds. In fact, scaffolds with similar pore size and porosity can provide important and varied permeability due to different pore  shape, interconnectivity and tortuosity. However, the effects of scaffold permeability on seeded cells remains largely unknown during tissue regeneration in vitro. In this study, we measured the Darcy permeability (K) of tri-calcium phosphate scaffolds by distributed them into three groups: Low, Medium and High.  As a result, the effects of scaffold permeability on cell proliferation, cellular activity and growth in the inner pores were investigated in perfused and static cultures in vitro. Results demonstrated that higher permeable scaffolds exhibited superior performance during bone regeneration in vitro and the advantages of higher scaffold permeability were amplified in perfused culture. Based on these findings, scaffold permeability should be considered in future scaffold fabrications. Copyright © 2013 John Wiley & Sons, Ltd.

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[542]

TÍTULO / TITLE:  - HGF and c-Met Interaction Promotes Migration in Human Chondrosarcoma Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e53974. doi: 10.1371/journal.pone.0053974. Epub 2013 Jan 8.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0053974

AUTORES / AUTHORS:  - Tsou HK; Chen HT; Hung YH; Chang CH; Li TM; Fong YC; Tang CH

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan  ; Department of Materials Science and Engineering, Feng Chia University, Taichung, Taiwan ; Department of Early Childhood Care and Education, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli County, Taiwan.

RESUMEN / SUMMARY:  - Chondrosarcoma is a type of highly malignant tumor with a potent capacity for local invasion and causing distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Hepatocyte growth factor (HGF) has been demonstrated to stimulate cancer proliferation, migration, and metastasis. However, the effect of HGF on migration activity of human chondrosarcoma cells is not well known. Here, we found that human chondrosarcoma tissues demonstrated significant expression of HGF, which was higher than that in normal cartilage. We also found that HGF increased the migration and expression of matrix metalloproteinase (MMP)-2 in human chondrosarcoma cells. c-Met inhibitor and siRNA reduced HGF-increased cell migration and MMP-2 expression. HGF treatment resulted in activation of the phosphatidylinositol 3’-kinase (PI3K)/Akt/PKCdelta/NF-kappaB pathway, and HGF-induced expression of MMP-2 and cell migration was inhibited by specific inhibitors or siRNA-knockdown of PI3K, Akt, PKCdelta, and NF-kappaB cascades. Taken together, our results indicated that HGF enhances migration of chondrosarcoma cells by increasing MMP-2 expression through the c-Met receptor/PI3K/Akt/PKCdelta/NF-kappaB signal transduction pathway.

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[543]

TÍTULO / TITLE:  - beta-Catenin Directly Sequesters Adipocytic and Insulin Sensitizing Activities but Not Osteoblastic Activity of PPARgamma2 in Marrow Mesenchymal Stem Cells.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2012;7(12):e51746. doi: 10.1371/journal.pone.0051746. Epub 2012 Dec 18.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0051746

AUTORES / AUTHORS:  - Rahman S; Czernik PJ; Lu Y; Lecka-Czernik B

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, University of Toledo College of Medicine, Toledo, Ohio, United States of America ; Center for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, Ohio, United States of America.

RESUMEN / SUMMARY:  - Lineage allocation of the marrow mesenchymal stem cells (MSCs) to osteoblasts and adipocytes is dependent on both Wnt signaling and PPARgamma2 activity. Activation of PPARgamma2, an essential regulator of energy metabolism and insulin sensitivity, stimulates adipocyte and suppresses osteoblast differentiation and bone formation, and correlates with decreased bone mass and increased fracture rate. In contrast, activation of Wnt signaling promotes osteoblast differentiation, augments bone accrual and reduces total body fat. This study examined the cross-talk between PPARgamma2 and beta-catenin, a key mediator of canonical Wnt signaling, on MSC lineage determination. Rosiglitazone-activated PPARgamma2 induced rapid proteolytic degradation of beta-catenin, which was prevented by either inhibiting glycogen synthase kinase 3 beta (GSK3beta) activity, or blocking pro-adipocytic activity of PPARgamma2 using selective antagonist GW9662 or mutation within PPARgamma2 protein. Stabilization of beta-catenin suppressed PPARgamma2 pro-adipocytic but not anti-osteoblastic activity. Moreover, beta-catenin stabilization decreased PPARgamma2-mediated insulin signaling as measured by insulin receptor and FoxO1 gene expression, and  protein levels of phosphorylated Akt (pAkt). Cellular knockdown of beta-catenin with siRNA increased expression of adipocyte but did not affect osteoblast gene markers. Interestingly, the expression of Wnt10b was suppressed by anti-osteoblastic, but not by pro-adipocytic activity of PPARgamma2. Moreover, beta-catenin stabilization in the presence of activated PPARgamma2 did not restore Wnt10b expression indicating a dominant role of PPARgamma2 in negative regulation of pro-osteoblastic activity of Wnt signaling. In conclusion, beta-catenin and PPARgamma2 are in cross-talk which results in sequestration of pro-adipocytic and insulin sensitizing activity. The anti-osteoblastic activity of PPARgamma2 is independent of this interaction.

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[544]

TÍTULO / TITLE:  - Sphere-forming tumor cells possess stem-like properties in human fibrosarcoma primary tumors and cell lines.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2012 Dec;4(6):1315-1320. Epub 2012 Sep 26.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.940

AUTORES / AUTHORS:  - Liu WD; Zhang T; Wang CL; Meng HM; Song YW; Zhao Z; Li ZM; Liu JK; Pan SH; Wang WB

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University;

RESUMEN / SUMMARY:  - Fibrosarcoma is a malignant soft tissue tumor of mesenchymal origin. Despite advances in medical and surgical treatment, patient survival rates have remained  poor. According to the cancer stem cell hypothesis, tumors are comprised of heterogeneous cell populations that have different roles in tumor formation and growth. Cancer stem cells are a small cell subpopulation that exhibits stem-like  properties to gain aggressiveness and recurrence. These cells have been identified in a variety of cancerous tumors, but not in human fibrosarcoma. In this study, we observed that HT1080 cells and primary fibrosarcoma cells formed spheres and showed higher self-renewal capacity, invasiveness and drug resistance compared with their adherent counterparts. Moreover, we demonstrated that the cells showed higher expression of the embryonic stem cell-related genes Nanog, Oct3/4, Sox2, Sox10 and their encoding proteins, as well as greater tumorigenic capacity in nude mice. In conclusion, our data suggest the presence of a stem-like cell population in human fibrosarcoma tumors, which provides more evidence for the cancer stem cell hypothesis and assistance in designing new therapeutic strategies against human fibrosarcoma.

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[545]

TÍTULO / TITLE:  - High fatigue scores before and after surgical treatment of bone and soft tissue tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Ther Med. 2013 Jan;5(1):205-208. Epub 2012 Oct 31.

            ●● Enlace al texto completo (gratuito o de pago) 3892/etm.2012.786

AUTORES / AUTHORS:  - VAN DER Geest IC; Knoop H; Veth RP; Schreuder HW; Bleijenberg G

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery;

RESUMEN / SUMMARY:  - The first objective of the present study was to investigate fatigue severity in patients diagnosed with bone and soft tissue tumors prior to the surgical treatment of the tumor and 6 months post-operatively. The second objective was to determine which variables are associated with severe fatigue. Patients diagnosed  with benign or low-grade malignant bone and soft tissue tumors, undergoing surgical therapy for the tumor only, were included in this study. The control group contained patients scheduled for knee arthroscopy for suspected meniscus tears. Fatigue, pain, anxiety and self-efficacy were measured pre-operatively and after 6 months and each patient wore an actometer to quantify physical activity.  In the tumor group of 43 patients, 35% were severely fatigued pre-operatively and 33% post-operatively. The tumor group reported a significantly higher level of anxiety. No differences were observed in pain, physical limitations, self-efficacy or actometer scores. Multiple regression analysis of the tumor group revealed that higher pain scores, higher state anxiety and lower self-efficacy were asssociated with fatigue severity. In the control group of 24  knee arthroscopy patients, the percentage of severely fatigued patients decreased from 38% (n=9) prior to treatment to 29% (n=7) 6 months later. A substantial number of patients were severely fatigued in both the tumor group and the knee arthroscopy group. Self-efficacy, pain and anxiety appear to be the most important variables associated with fatigue severity in tumor patients prior to surgery.

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[546]

TÍTULO / TITLE:  - Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Discov. 2012 Dec;2(12):1109-17. doi: 10.1158/2159-8290.CD-12-0197.

            ●● Enlace al texto completo (gratuito o de pago) 1158/2159-8290.CD-12-0197

AUTORES / AUTHORS:  - Braas D; Ahler E; Tam B; Nathanson D; Riedinger M; Benz MR; Smith KB; Eilber FC; Witte ON; Tap WD; Wu H; Christofk HR

INSTITUCIÓN / INSTITUTION:  - Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA.

RESUMEN / SUMMARY:  - Unlike many cancers that exhibit glycolytic metabolism, high-grade liposarcomas often exhibit low 2[18F]fluoro-2-deoxy-D-glucose uptake by positron emission tomography (PET), despite rapid tumor growth. Here, we used liquid chromatography tandem mass spectrometry to identify carbon sources taken up by liposarcoma cell  lines derived from xenograft tumors in patients. Interestingly, we found that liposarcoma cell lines consume nucleosides from culture media, suggesting nucleoside salvage pathway activity. The nucleoside salvage pathway is dependent  on deoxycytidine kinase (dCK) and can be imaged in vivo by PET with 1-(2’-deoxy-2’-[18F]fluoroarabinofuranosyl) cytosine (FAC). We found that liposarcoma cell lines and xenograft tumors exhibit dCK activity and dCK-dependent FAC uptake in vitro and in vivo. In addition, liposarcoma cell lines and xenograft tumors are sensitive to treatment with the nucleoside analogue prodrug gemcitabine, and gemcitabine sensitivity is dependent on dCK expression. Elevated dCK activity is evident in 7 of 68 clinical liposarcoma samples analyzed. These data suggest that a subpopulation of liposarcoma patients have tumors with nucleoside salvage pathway activity that can be identified noninvasively using [18F]-FAC-PET and targeted using gemcitabine. SIGNIFICANCE: Patients with high-grade liposarcoma have poor prognoses and often fail to respond to chemotherapy. This report identifies elevated nucleoside salvage activity in a subset of liposarcomas that are identifiable using noninvasive PET  imaging with FAC and that are sensitive to gemcitabine. Thus, we suggest a new treatment paradigm for liposarcoma patients that uses [18F]-FAC-PET in the clinic to delineate gemcitabine responders from nonresponders.

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[547]

TÍTULO / TITLE:  - The pedicled myocutaneous flap as a choice reconstructive technique for immediate adjuvant brachytherapy in sarcoma treatment.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Curr Oncol. 2012 Dec;19(6):e491-5. doi: 10.3747/co.19.1141.

            ●● Enlace al texto completo (gratuito o de pago) 3747/co.19.1141

AUTORES / AUTHORS:  - Saba SC; Shaterian A; Tokin C; Dobke MK; Wallace AM

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Division of Plastic and Reconstructive Surgery, University of California-San Diego, CA, U.S.A.

RESUMEN / SUMMARY:  - Successful treatment of soft-tissue sarcomas is highly dependent on total tumour  resection coupled with adjuvant radiation therapy to achieve local control and decrease recurrence. Reconstruction of soft-tissue defects after resection aims to cover vital structures, while providing enough stable tissue to withstand adjuvant brachytherapy treatment. In the present study, pedicled myocutaneous flaps were used as a vital adjunct in the treatment of soft-tissue sarcoma, and our experience with 2 such patients is described. The flaps served to reconstruct large three-dimensional defects while providing stable coverage over brachytherapy hardware to allow for delivery of radiation in the immediate postoperative period. Pedicled locoregional myocutaneous flaps provide a safe, easy, and reliable reconstructive technique in the treatment of soft-tissue sarcoma.

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[548]

TÍTULO / TITLE:  - Kaposi’s sarcoma associated with treatment with adalimumab.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dermatol Ther. 2012 Nov-Dec;25(6):619-20. doi: 10.1111/j.1529-8019.2012.01523.x.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1529-8019.2012.01523.x

AUTORES / AUTHORS:  - Amadu V; Satta R; Montesu MA; Cottoni F

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Microsurgery and Microsurgical Specialisation, University  of Sassari, Sassari, Italy.

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[549]

TÍTULO / TITLE:  - Leiomyoma treatment by uterine artery embolization using gelatin sponge prepared  by the pumping method.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Ther Med. 2012 Nov;4(5):781-784. Epub 2012 Aug 29.

            ●● Enlace al texto completo (gratuito o de pago) 3892/etm.2012.688

AUTORES / AUTHORS:  - Kojima T; Taki Y; Fujisawa H; Koyama K

INSTITUCIÓN / INSTITUTION:  - Amor Clinic, Kanagawa 222-0033;

RESUMEN / SUMMARY:  - Uterine leiomyoma, a benign tumor, may be treated with drugs, albeit surgical resection is more common. The present study aimed to evaluate the treatment of leiomyoma cases by uterine artery embolization (UAE) using a gelatin sponge prepared by the pumping method. The results of 700 leiomyoma cases treated by UAE in the outpatient department were evaluated. UAE was performed by injecting gelatin sponge prepared by the pumping method into the uterine artery. Among 700  cases, effective cases were 680 (97.2%), ineffective cases were 18 (2.8%) and impossible cases for UAE were 2 (0.2%). Retreatment was required in 23 cases (3.3%). Complication events designated by the Society of Interventional Radiology Clinical Practice Guidelines occurred in 31 cases (4.4%): 1 case showed permanent adverse sequelae, 4 cases required major therapy with a prolonged hospitalization (>48 h) and 10 patients required therapy with minor hospitalization (<48 h). The  remaining 16 cases required nominal or no therapy. Follow-up of patients was performed for 599 cases for an average period of 1.2+/-0.9 years, ranging between 1 month and 6 years. Pregnancy after UAE was observed in 12 cases/15 cycles. Thus, the findings indicate that UAE using gelatin sponge prepared by the pumping method applied to outpatients is a safe and useful treatment procedure.

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[550]

TÍTULO / TITLE:  - Pazopanib for the treatment of soft-tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Pharmacol. 2012;4:65-70. doi: 10.2147/CPAA.S33195. Epub 2012 Oct 26.

            ●● Enlace al texto completo (gratuito o de pago) 2147/CPAA.S33195

AUTORES / AUTHORS:  - Heudel P; Cassier P; Derbel O; Dufresne A; Meeus P; Thiesse P; Ranchere-Vince D; Blay JY; Ray-Coquard I

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Leon Berard Center, Lyon, France.

RESUMEN / SUMMARY:  - Pazopanib is a multikinase inhibitor which potently inhibits the activity of major receptor tyrosine kinases, including vascular endothelial growth factor receptor-1, vascular endothelial growth factor receptor-2, vascular endothelial growth factor receptor-3, platelet-derived growth factor receptor-a, platelet-derived growth factor receptor-a, and c-Kit. Approved by the Food and Drug Administration in 2009 in the United States for the treatment of metastatic  renal cell carcinoma, pazopanib has been tested in advanced or metastatic soft-tissue sarcoma. Unlike other tyrosine kinase inhibitors, a statistically significant efficacy in phase II but also in randomized phase III studies has been shown. In comparison with sunitinib or sorafenib, pazopanib has a similar toxicity profile and is generally well tolerated. This review details the development of this new therapeutic class in the treatment of metastatic soft-tissue sarcomas.

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[551]

TÍTULO / TITLE:  - Secondary Hip Osteoarthritis due to Neurofibroma Treated with Total Hip Replacement.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Orthop. 2012;2012:173921. doi: 10.1155/2012/173921. Epub 2012 Oct 23.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/173921

AUTORES / AUTHORS:  - Tangsataporn S; Shakib A; Kuzyk PR; Backstein DJ; Gross AE; Safir OA

INSTITUCIÓN / INSTITUTION:  - Division of Arthroplasty, Orthopedic Department, Mount Sinai Hospital, 600 University Avenue, Suite 476A, Toronto, ON, Canada M5G 1X5.

RESUMEN / SUMMARY:  - Background. Local plexiform neurofibroma can lead to deformity of the pelvis, valgus deformity of femoral neck, and joint capsule laxity. We report a case of secondary hip osteoarthritis with subluxation and coxa vara deformity resulting from an extra-articular neurofibroma treated with total hip replacement. Case Description. A 39-year-old man had a large benign plexiform neurofibroma at buttock which induced secondary osteoarthritis of the hip. Conservative treatment of tumor was selected because the patient had low chance of malignant transformation due to absence of other neurofibromatosis features. However, due to secondary osteoarthritis he underwent total hip arthroplasty. Anterior capsulotomy was selected to avoid large posterior hip tumor mass. In order to avoid the difficulties associated with setting tension of the abductor muscle, modified trochanteric slide osteotomy with trochanteric advancement, lateralized  cup placement, and extended neck offset were used. One year after the surgery, the patient had excellent clinical function, hip stability, leg length equality and was satisfied with the outcome. Clinical Relevance. We concluded that the modified trochanteric slide osteotomy with trochanteric advancement represents a  valuable approach for THR in patients with extremely elongation of the hip abductor and secondary hip osteoarthritis resulting from extra-articular neurofibroma.

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[552]

TÍTULO / TITLE:  - Bone sarcomas: from biology to targeted therapies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2012;2012:301975. doi: 10.1155/2012/301975. Epub 2012 Nov 27.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/301975

AUTORES / AUTHORS:  - Gaspar N; Di Giannatale A; Geoerger B; Redini F; Corradini N; Enz-Werle N; Tirode F; Marec-Berard P; Gentet JC; Laurence V; Piperno-Neumann S; Oberlin O; Brugieres L

INSTITUCIÓN / INSTITUTION:  - Department of Oncology for Children and Adolescents, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif Cedex, France.

RESUMEN / SUMMARY:  - Primary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare diseases which occur mainly in adolescents and young adults. With the current therapies, some patients remain very difficult to treat, such as tumour with poor histological response to preoperative CT (or large initial tumour volume for Ewing sarcomas not operated), patients with multiple metastases at or those who relapsed. In order to develop new therapies against these rare tumours, we need to unveil the key driving factors and molecular abnormalities behind the malignant characteristics and to broaden our understanding of the phenomena sustaining the metastatic phenotype and treatment resistance in these tumours. In this paper, starting with the biology of these tumours, we will discuss potential therapeutic targets aimed at increasing local tumour control, limiting metastatic spread, and finally improving patient survival.

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[553]

TÍTULO / TITLE:  - Nanomedicine for uterine leiomyoma therapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Ther Deliv. 2013 Feb;4(2):161-75. doi: 10.4155/tde.12.144.

            ●● Enlace al texto completo (gratuito o de pago) 4155/tde.12.144

AUTORES / AUTHORS:  - Ali H; Kilic G; Vincent K; Motamedi M; Rytting E

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA.

RESUMEN / SUMMARY:  - Background: The purpose of this work was to engineer polymeric nanoparticles to encapsulate and deliver 2-methoxyestradiol, a potential antitumor drug for treatment of uterine leiomyoma (fibroids), the most common hormone-dependent pathology affecting women of reproductive age. Methods/Results: Encapsulation efficiency and drug release from the nanoparticles were monitored by HPLC. Cell morphology and in vitro cytotoxicity experiments were carried out in a human leiomyoma cell line. The nanoparticles displayed high encapsulation efficiency (>86%), which was verified by differential scanning calorimetry and x-ray diffraction. Excellent long-term stability of the nanoparticles and gradual drug  release without burst were also observed. Cellular uptake of fluorescent nanoparticles was confirmed by confocal imaging. The drug-loaded poly(lactic acid) and poly(lactic-co-glycolic acid) nanoparticles induced cytotoxicity in human leiomyoma cells to a significantly greater extent than the free drug at 0.35 microM. Conclusion: This novel approach represents a potential fertility-preserving alternative to hysterectomy.

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[554]

TÍTULO / TITLE:  - Systemic therapy in soft tissue sarcomas: past, present and future.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):327-31. doi: 10.1007/s13193-012-0140-8. Epub 2012 Mar 8.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-012-0140-8

AUTORES / AUTHORS:  - Purohit S; Bhise R; Appachu S; Lakshmaiah KC; Govindbabu K

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Dr M.H Marigowda road, Bangalore, -560029 India.

RESUMEN / SUMMARY:  - Soft tissue sarcomas (STS) comprise 1% of all cancers diagnosed worldwide with more than 40 different histological subtypes each with distinct underlying biology, natural history and response to treatment. Due to the differential chemosensitivity it is imperative to have a correct histological diagnosis for optimal treatment of these patients. Even though surgery remains the primary modality of treatment there is increasing specialization of chemotherapy with respect to histological subtype. In general there is no place for “one size fits  all strategy”. To correctly define the role of chemotherapy, an extensive search  was carried out online and offline for all relevant articles concerning chemotherapy in soft tissue sarcoma. This review aims to discuss the evolution of chemotherapy, its present role in neoadjuvant, adjuvant, metastatic settings and  exciting trends with the advent of targeted therapies.

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[555]

TÍTULO / TITLE:  - Biomarkers and Novel Therapeutic Targets in Gastrointestinal Stromal Tumors (GISTs).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Recent Pat Anticancer Drug Discov. 2012 Nov 26.

AUTORES / AUTHORS:  - Campanella NC; de Oliveira AT; Scapulatempo-Neto C; Peixoto-Guimaraes D; Reis RM

INSTITUCIÓN / INSTITUTION:  - Molecular Oncology Research Center, Barretos Cancer Hospital, Rua Antenor Duarte  Villela, 1331, CEP 14784 400, Barretos, Sao Paulo, Brazil. ruireis.hcb@gmail.com.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs) are usually driven by activating mutations in mast/stem cell growth factor receptor (KIT) or platelet-derived growth factor receptor A (PDGFRA) oncogenes. Both KIT and PDGFRA are member of the type III transmembrane receptor tyrosine kinase family that stimulate intracellular signaling pathways controlling cell proliferation, adhesion, apoptosis, survival, and differentiation. The presence and type of KIT/PDGFRA mutations are the best predictive factor to imatinib mesylate therapy, a selective tyrosine kinase inhibitor. Nevertheless, a small proportion of GISTs are wild-type for both KIT and PDGFRA genes, and tumors frequently acquired secondary mutations on KIT, which leads to imatinib resistance. Currently, new patents to the GISTs imatinib resistant have been proposed. Sunitinib, is now-a-days used as second line therapy for patients with imatinib-resistant or imatinib-intolerant GIST, and many more drugs are in evaluation, such as masitinib and valatinib. In the present study we will review GISTs diagnostic, prognostic and therapeutic biomarkers and address the development of novel patents for the treatment of these patients.

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[556]

TÍTULO / TITLE:  - Multimodality therapy for metastatic sarcomas confined to the lung.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2012 Oct;4(4):583-587. Epub 2012 Jul 24.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.820

AUTORES / AUTHORS:  - Gollard RP; Turner JF

INSTITUCIÓN / INSTITUTION:  - Honors College;

RESUMEN / SUMMARY:  - Metastectomy or resection of sarcomas which have metastasized to the lung from other sites has a long and established history. At present, there are more than forty different drugs with activity in soft tissue sarcomas. A number of sarcomas demonstrate differential sensitivities to chemotherapy and targeted agents. Intimate knowledge of the biological behavior of each distinct type of sarcoma should predicate what treatment or protocol is most suitable. Certain patients might benefit from either neoadjuvant or adjuvant therapy following the resection of metastatic lesions. Much remains to be learned about the differential sensitivities of various sarcomas to different treatment regimens.

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[557]

TÍTULO / TITLE:  - Diagnostic imaging in veterinary dental practice. Osteoma, a benign bone tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Am Vet Med Assoc. 2012 Dec 15;241(12):1573-5. doi: 10.2460/javma.241.12.1573.

            ●● Enlace al texto completo (gratuito o de pago) 2460/javma.241.12.1573

AUTORES / AUTHORS:  - Volker MK; Luskin IR

INSTITUCIÓN / INSTITUTION:  - Animal Dental Center, Towson, MD 21286, USA. mary.krakowski@animaldentalcenter.com

 

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[558]

TÍTULO / TITLE:  - CT and MR imaging of gastrointestinal stromal tumor of stomach: a pictorial review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Quant Imaging Med Surg. 2012 Dec;2(4):274-9. doi: 10.3978/j.issn.2223-4292.2012.11.01.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2223-4292.2012.11.01

AUTORES / AUTHORS:  - Gong J; Kang W; Zhu J; Xu J

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Shenzhen People’s Hospital, Jinan University Second Clinical Medicine College, Shenzhen, 518020, China.

RESUMEN / SUMMARY:  - This pictorial review illustrates CT and MR imaging appearance of gastrointestinal stromal tumor (GIST) of the stomach and other lesions with similar imaging appearance. GIST of the stomach appears as well-defined enhanced  masses with characteristics of subeppthial neoplasms. Majority are exophytic growth, but can also be of intra-luminal growth. GIST can growth into a large mass without gastrointestinal tract obstruction. Necrosis is often seen in GIST and results in heterogeneous enhancement and communication with gastrointestinal  tract. CT and MRI features of several other neoplasms mimicking GISTs in the stomach are also described in this review.

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[559]

TÍTULO / TITLE:  - Use of surgery and mitoxantrone chemotherapy in a dog with disseminated lymphangiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Am Vet Med Assoc. 2012 Dec 15;241(12):1639-44. doi: 10.2460/javma.241.12.1639.

            ●● Enlace al texto completo (gratuito o de pago) 2460/javma.241.12.1639

AUTORES / AUTHORS:  - Sicotte V; Benamou J; Fifle LC; Plante J; Lacoste HI; Joly H; Stern AW

INSTITUCIÓN / INSTITUTION:  - Faculte de medecine veterinaire, Universite de Montreal, St-Hyacinthe, QC, Canada.

RESUMEN / SUMMARY:  - CASE DESCRIPTION: A 5-year-old sexually intact male Giant Schnauzer was evaluated because of difficulty breathing and left pelvic limb swelling. Eighteen months previously, the patient had had intermittent left pelvic limb swelling, but the owner declined further testing at that time. CLINICAL FINDINGS: Physical examination revealed severe pitting edema of the left pelvic limb and prepuce and muffled heart sounds on thoracic auscultation. Results of thoracic radiography and thoracocentesis were consistent with chylothorax, and CT imaging of the thorax and abdomen revealed a mass involving the whole left sublumbar area. TREATMENT AND OUTCOME: In an attempt to treat the chylothorax, pleural omentalization and pericardectomy were performed. Histologic evaluation of several biopsy specimens harvested in the abdominal and thoracic cavities revealed disseminated lymphangiosarcoma. The patient recovered well from surgery, and mitoxantrone chemotherapy was administered. As of 10 months after surgery, the dog was clinically normal except for mild pelvic limb edema. CLINICAL RELEVANCE: The combination of clinical signs, multiple imaging features, surgical findings, and histologic examination findings enabled the final diagnosis of lymphangiosarcoma. Clinical management that included medical and surgical treatments and chemotherapy resulted in improved quality of life and extended survival time in a dog with metastatic lymphangiosarcoma.

 

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[560]

TÍTULO / TITLE:  - Giant cell fibroma: A clinicopathological study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Maxillofac Pathol. 2012 Sep;16(3):359-62. doi: 10.4103/0973-029X.102485.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0973-029X.102485

AUTORES / AUTHORS:  - Sabarinath B; Sivaramakrishnan M; Sivapathasundharam B

INSTITUCIÓN / INSTITUTION:  - Department of Oral Pathology and Microbiology, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, India.

RESUMEN / SUMMARY:  - OBJECTIVE: Giant cell fibromas (GCF) of the oral cavity are found predominantly in Caucasians and rarely in other races. This retrospective study was done to evaluate the clinicopathological features of GCFs in a sample of Indian population. MATERIALS AND METHODS: 21 oral GCF cases were investigated from the year 1995 to 2010. Clinical data and microscopic features were reviewed and analyzed. RESULTS: The mean age of patients at the time of diagnosis was 39years. Oral GCF occurred in patients between 6 and 67 years of age. The lesions were 4-17 mm in greatest dimension. GCF frequently has the provisional diagnosis of fibroma or papilloma. All tumors were treated by total surgical excision and no recurrence was reported. The consistent and diagnostic feature was the presence of large stellate giant cells, usually with one or two nuclei. Multinucleated giant cells were seen occasionally. These giant cells were most numerous in the connective tissue beneath the epithelium. CONCLUSION: Though there are distinct histopathologic features for GCF, its clinical presentation and prognosis are similar to the conventional fibroma/fibroepithelial polyp.

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[561]

TÍTULO / TITLE:  - Intraoral lipoma: a rare clinical entity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 28;2013. pii: bcr2012007889. doi: 10.1136/bcr-2012-007889.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007889

AUTORES / AUTHORS:  - Agarwal R; Kumar V; Kaushal A; Singh RK

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, Chandra Dental College and Hospital, Barabanki, Uttar Pradesh, India.

RESUMEN / SUMMARY:  - Lipoma is a painless soft tissue tumour of the mesenchymal origin, which is slow  growing and well circumscribed. The occurrence of lipoma is rare in the oral cavity (1-4%); however, the frequency is much higher in the head and neck region. The tumour is mostly present in the buccal mucosa, lips, tongue, palate, buccal sulcus and floor of the mouth. Sometimes the tumour becomes large enough to cause difficulty in speech and mastication. Histologically, lipoma is composed of mature fat cells, surrounded by normal fat. We present two cases of intraoral lipoma in two female patients.

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[562]

TÍTULO / TITLE:  - Visceral Kaposi’s Sarcoma Related to Human Herpesvirus-8 in Liver Transplant Recipient: Case Report and Literature Review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol Med. 2012;2012:137291. doi: 10.1155/2012/137291. Epub 2012 Dec 19.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/137291

AUTORES / AUTHORS:  - Benhammane H; Mentha G; Tschanz E; El Mesbahi O; Dietrich PY

INSTITUCIÓN / INSTITUTION:  - Department of Medical Oncology, Hassan II University Hospital, Fez, Morocco.

RESUMEN / SUMMARY:  - Background. Kaposi’s sarcoma (KS) in transplant recipients is about 400 to 500 times rate in the general population. It is strongly associated to Human herpesvirus-8 (HHV-8) infection which has been found in 95% of KS lesions. The optimal approach to managing posttransplantation KS is to reduce or discontinue immunosuppressive therapy but this strategy carries a risk of the acute rejection of the graft. Recently, the use of an mTOR inhibitor has added new opportunities  for KS treatment and prevention. Case Report. We report a case of 24 years-old Turkish woman with visceral HHV-8-associated Kaposi’s sarcoma after orthotopic liver transplantation. Conclusion. Posttransplantation KS is considered an experimental model of virus induced tumor suggesting the usefulness of HHV-8 screening in transplant recipient and donor. Therapeutic approaches are complex and require a multidisciplinary team.

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[563]

TÍTULO / TITLE:  - Dermatofibrosarcoma protuberans in a child: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Dermatol Med. 2012;2012:796818. doi: 10.1155/2012/796818. Epub 2012 Dec  18.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/796818

AUTORES / AUTHORS:  - Goyal P; Sehgal S; Singh S; Rastogi S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Swami Dayanand Hospital, Shahdara, New Delhi 110095, India.

RESUMEN / SUMMARY:  - Background. Dermatofibrosarcoma protuberans (DFSP) is an intermediate grade soft  tissue neoplasm originating from the dermal layer of the skin. It usually occurs  in adults; however, it can rarely be seen in infancy and childhood. Diagnosis of  DFSP in children is quite difficult-given-rarity of this lesion, its variegated appearance, and its presentation sometimes at unusual sites. Case. We present the case of five-year-old boy who came with painless lesion on a forehead. Fine needle aspiration cytology (FNAC) suggested possibility of mesenchymal neoplasm.  Patient was advised excision biopsy. Final diagnosis of DFSP was made based on histopathological findings. The patient was then advised reexcision surgery with  wide margins. The patient was lost to followup and later turned up after two months with recurrence of a similar swelling at the same site. Conclusion. DFSP in children is rare and difficult to diagnose. Treatment of childhood DFSP is often delayed leading to incomplete excision. Hence, there is need to recognize and appropriately manage this uncommon childhood neoplasm.

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[564]

TÍTULO / TITLE:  - Discounting a surgical risk: data, understanding, and gist.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Virtual Mentor. 2012 Jul 1;14(7):532-8. doi: 10.1001/virtualmentor.2012.14.7.ecas1-1207.

            ●● Enlace al texto completo (gratuito o de pago) 1001/virtualmentor.2012.14.7.ecas1-1207

AUTORES / AUTHORS:  - Schwartz PH

INSTITUCIÓN / INSTITUTION:  - Faculty investigator at the Indiana University Center for Bioethics, and assistant professor of medicine at Indiana University School of Medicine, and assistant professor of philosophy at Indiana University-Purdue University Indianapolis (IUPUI).

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[565]

TÍTULO / TITLE:  - Non syndromic gingival fibromatosis in a mild mental retardation child.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Contemp Clin Dent. 2012 Sep;3(Suppl 2):S206-9. doi: 10.4103/0976-237X.101096.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0976-237X.101096

AUTORES / AUTHORS:  - Duddu MK; Muppa R; Reddy GS; Reddy PV

INSTITUCIÓN / INSTITUTION:  - Department of Pedodontics and Preventive Dentistry, Panineeya Institute of Dental Sciences and Hospital, Dilsuknagar, Hyderabad, Andhra Pradesh, India.

RESUMEN / SUMMARY:  - Gingival fibromatosis is a benign oral condition characterized by enlargement of  gingival tissues. It usually develops as an isolated disorder but can be one of the features of a syndrome. This case report is of a 5-year-old male with severe  gingival hyperplasia and mild mental retardation which was complicated by open bite, abnormal occlusion, open lip posture, and disabilities associated with mastication and speech. Full mouth gingivectomy in single sitting under general anesthesia was done with electrocautery.

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[566]

TÍTULO / TITLE:  - NY-ESO-1 expression in sarcomas: A diagnostic marker and immunotherapy target.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncoimmunology. 2012 Nov 1;1(8):1409-1410.

            ●● Enlace al texto completo (gratuito o de pago) 4161/onci.21059

AUTORES / AUTHORS:  - Lai JP; Rosenberg AZ; Miettinen MM; Lee CC

INSTITUCIÓN / INSTITUTION:  - Laboratory of Pathology; National Cancer Institute; NIH; Bethesda, MD USA.

RESUMEN / SUMMARY:  - NY-ESO-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ESO-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ESO-1-targeted immunotherapy in  subsets of melanoma and synovial sarcoma patients.

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[567]

TÍTULO / TITLE:  - Risk factors for adenomyosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Nepal Health Res Counc. 2012 Sep;10(22):229-33.

AUTORES / AUTHORS:  - Shrestha A

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynaecology, Chitwan Medical College, Chitwan, Nepal.

RESUMEN / SUMMARY:  - Background: Adenomyosis was largely underdiagnosed before hysterectomy as little  was understood regarding the aetiopathogenesis, clinical symptoms and difficult to confirm pre-operatively. Thus, the aim was to evaluate the possible associated risk factors foradenomyosis Methods: This cross sectional study was done on women who underwent hysterectomy between15th March 2010 to 15th Jan 2012 in Chitwan Medical College. Information was collected on clinical symptoms, menstrual, reproductive factors, contraception history and smoking habits. Presence of adenomyosis was as certained from pathological record. Results: Out of 160 women, adenomyosis was identified in 69 (43.1%).The frequency of adenomyosis was higher  in parous women in comparison with nullipara (OR 1.8, 95%CI 1.5-2.0, p<0.03). Similarly, women reporting one or more spontaneous abortion and having prior dilatation and curettage had an odds ratio for adenomyosis of 1.4 and 1.9.Women who smoked were at increased risk of the condition, in comparison with women who  had never smoked; the risk was 1.4 (95%0.7-2.7) and the risk increased with duration of smoking; the OR being 3.6 in those who smoked more than 10 years compared to those who smoked less than 10 years (p=0.008). Likewise, women having irregular menstrual cycle had an odds ratio of 1.7 (95%, CI 0.9-3.3) for adenomyosis, in comparison with those women with regular cycle (p=0.04). Conclusions: Multiparity, previous abortion, dilatation and currattage, chronic smoker and women having irregular cycles were more risk of having adenomyosis.Still, there is a need of larger population based prospective epidemiological studies to find out clear aetiopathology and clinical symptoms of adenomyosis. Keywords: adenomyosis; epidemiology; risk factors.

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[568]

TÍTULO / TITLE:  - Voluminous extracardiac adult rhabdomyoma of the neck: a case presentation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Surg. 2012;2012:984789. doi: 10.1155/2012/984789. Epub 2012 Dec 6.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/984789

AUTORES / AUTHORS:  - Maglio R; Francesco S; Paolo M; Stefano V; Francesco D; Giovanni R

INSTITUCIÓN / INSTITUTION:  - General Surgery Department, S. Andrea Hospital, Sapienza University of Rome, Grottarossa Street 1035-1039, 00189 Rome, Italy.

RESUMEN / SUMMARY:  - Introduction. Rhabdomyomas of the head and neck are exceptionally rare benign mesenchymal tumors. Rare cases have been reported to involve other sites of the body including the head and neck regions. Case Presentation. We report a case of  voluminous extracardiac adult rhabdomyoma affecting adult patients and initially  seen as slowly growing, indolent neoplasms. The patient is a seventy-year old male Italian patient. Conclusion. Adult extracardiac rhabdomyoma is a rare benign tumor that may present with symptoms that vary from aerodigestive tract obstruction to remaining asymptomatic for many years. Although histology is very  characteristic, several differential diagnoses have to be considered. To our knowledge, this is the first case of voluminous adult-type symptomless rhabdomyoma.

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[569]

TÍTULO / TITLE:  - Osteosarcoma diagnostic delay associated with alendronate-induced pain relief.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Surg Orthop Adv. 2012 Fall;21(3):165-9.

AUTORES / AUTHORS:  - Carter CJ; Ward WG

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC, USA.

RESUMEN / SUMMARY:  - A 32-year-old man with a painful osteoblastic osteosarcoma of the right hip was initially diagnosed as having Paget’s disease of bone. He was treated with alendronate for presumptive Paget’s disease. The patient’s bone pain was dramatically reduced by the administration of alendronate for 7 months. Following discontinuation of alendronate, his pain promptly recurred, culminating in a more thorough evaluation that led to the correct diagnosis. Despite chemotherapy, the  patient succumbed to metastatic osteosarcoma. The main purpose of this publication is to report the potential for pain relief when an osteosarcoma is treated with bisphosphonate medication. Clinicians are advised not to consider an alendronate-associated pain reduction in an osteoblastic lesion as an indicator of an underlying benign process of bone. The evaluation of painful sclerotic bone lesions is briefly reviewed.

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[570]

TÍTULO / TITLE:  - Sarcoma of the ewing family in pregnancy: a case report of intrauterine fetal death after induction of chemotherapy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol. 2012 Sep;5(3):633-8. doi: 10.1159/000345568. Epub 2012 Sep 27.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000345568

AUTORES / AUTHORS:  - Schur S; Wild J; Amann G; Kostler W; Langer M; Brodowicz T

INSTITUCIÓN / INSTITUTION:  - Comprehensive Cancer Center - Musculoskeletal Tumors, GIST, Bone and Soft Tissue  Sarcoma Program, Clinical Division of Oncology, Department of Internal Medicine I, Sarcoma Platform Austria, Vienna, Austria.

RESUMEN / SUMMARY:  - Ewing’s sarcoma is an ultra-orphan disease (2/1,000,000/year) which requires a multimodal therapy approach in high-volume centers. Treatment consists of pre-operative therapy followed by surgery and post-operative combination of chemo-radiotherapy. Experience with diagnosis and therapy of Ewing’s sarcoma in pregnancy is very limited. We herein report the case of an atypical Ewing’s sarcoma detected in the second trimester of gestation. Neoadjuvant chemotherapy was initiated and resulted in substantial tumor shrinkage and intrauterine fetal  death. The rare nature of this condition underlines once more the need for a multidisciplinary team to improve the quality of care for this highly special patient collective.

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[571]

TÍTULO / TITLE:  - Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2013 Jan 28;8(1):14.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-8-14

AUTORES / AUTHORS:  - Yang GZ; Li J; Jin H; Ding HY

RESUMEN / SUMMARY:  - ABSTRACT: Mammary sarcoma is extremely rare and the diagnosis is established only after metaplastic carcinomas and malignant phyllodes tumours are excluded. A rare case of not otherwise specified-type sarcoma with CD10 expression in the left breast in a 45-year-old female was presented. It was a high-grade tumour composed of spindle cells histologically. The immunohistochemical results showed that CD10, vimentin and EGFR were positive diffusely and SMA presented focally, whereas epithelial markers and other myoepithelial or myogenic markers were all negative. The electron microscope investigation demonstrated fibroblastlike features. The exact entity of the tumour remained to be studied because it resembles undifferentiated sarcoma or sarcomatoid metaplastic carcinoma to some degree, as well as high-grade malignant phyllodes tumour in particular. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9019879588725702.

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[572]

TÍTULO / TITLE:  - Hibernoma - a case series with multimodality imaging and pathologic correlation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Bull NYU Hosp Jt Dis. 2012;70(4):283-7.

AUTORES / AUTHORS:  - Kim AC; Sheikh A; Dharmadhikari R; Gravel D; Rakhra K; Di Primio G; Schweitzer ME

RESUMEN / SUMMARY:  - Hibernoma is an uncommon, benign tumor of brown fat origin. The distribution of this tumor originally was described as following the location of persistent brown fat within the subcutaneous tissue of the thorax (especially the periscapular and interscapular regions), neck, axilla, shoulder, and retroperitoneum. Recently, hibernoma was described as being most common in the thigh.

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[573]

TÍTULO / TITLE:  - A renal epithelioid angiomyolipoma/perivascular epithelioid cell tumor with TFE3  gene break visualized by FISH.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Mol Morphol. 2012 Dec;45(4):234-7. doi: 10.1007/s00795-012-0584-5. Epub 2012  Dec 7.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00795-012-0584-5

AUTORES / AUTHORS:  - Ohe C; Kuroda N; Hes O; Michal M; Vanecek T; Grossmann P; Tanaka Y; Tanaka M; Inui H; Komai Y; Matsuda T; Uemura Y

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Kansai Medical University, Hirakata Hospital, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, Japan.

RESUMEN / SUMMARY:  - We present a case of renal epithelioid angiomyolipoma (eAML)/perivascular epithelioid cell tumor (PEComa) with a TFE3 gene break visible by fluorescence in situ hybridization (FISH). Histologically, the tumor was composed of mainly epithelioid cells forming solid arrangements with small foci of spindle cells. In a small portion of the tumor, neoplastic cells displayed nuclear pleomorphism, such as polygonal and enlarged vesicular nuclei with prominent nucleoli. Marked vascularity was noticeable in the background, and perivascular hyaline sclerosis  was also seen. Immunohistochemically, neoplastic cells were diffusely positive for alpha-smooth muscle actin and melanosome in the cytoplasm. Nuclei of many neoplastic cells were positive for TFE3. FISH analysis of the TFE3 gene break using the Poseidon TFE3 (Xp11) Break probe revealed positive results. Reverse transcriptase-polymerase chain reactions (RT-PCR) for ASPL/TFE3, PRCC/TFE3, CLTC/TFE3, PSF/TFE3, and NonO/TFE3 gene fusions all revealed negative results. This is the first reported case of renal eAML/PEComa with a TFE3 gene break, and  it has unique histological findings as compared to previously reported TFE3 gene  fusion-positive PEComas. Pathologists should recognize that PEComa with TFE3 gene fusion can arise even in the kidney.

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[574]

TÍTULO / TITLE:  - Histological diagnosis of cardiac lipoma in an adult with tuberous sclerosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 3;2013. pii: bcr2012007484. doi: 10.1136/bcr-2012-007484.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007484

AUTORES / AUTHORS:  - Jabir S; Al-Hyassat S

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Broomfield Hospital, Chelmsford, Essex, UK.

RESUMEN / SUMMARY:  - Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem disorder caused by mutations in either of the two genes, TSC1 or TSC2, which code for the  proteins hamartin and tuberin, respectively. These proteins act as tumour-growth  suppressors with mutations in their genes leading to multiple hamartomatous growths throughout the central nervous system, lungs, heart, kidneys, eyes and skin. There have been reports of patients with TSC having an increased incidence  of cardiac neoplasms, especially rhabdomyomas. A much smaller proportion of TSC patients have also been reported to have either, angiomyolipomas or lipomas, the  diagnosis in these cases being made via CT. We present the first case of an adult with TSC, where a histological diagnosis of cardiac lipoma was made and discuss its implications.

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[575]

TÍTULO / TITLE:  - Contrast-enhanced MRI predicts local recurrence of osteoid osteoma after radiofrequency ablation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Imaging Radiat Oncol. 2012 Dec;56(6):617-21. doi: 10.1111/j.1754-9485.2012.02443.x. Epub 2012 Sep 5.

            ●● Enlace al texto completo (gratuito o de pago) 1111/j.1754-9485.2012.02443.x

AUTORES / AUTHORS:  - Mahnken AH; Bruners P; Delbruck H; Gunther RW; Plumhans C

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic and Interventional Radiology, RWTH Aachen, Aachen, Germany. andreas.mahnken@rwth-aachen.de

RESUMEN / SUMMARY:  - INTRODUCTION: Osteoid osteoma is a painful benign tumour, which is commonly treated by radiofrequency ablation (RFA). The goal of this study is to assess the value of contrast-enhanced magnetic resonance imaging (MRI) for predicting clinical success after RFA of osteoid osteoma. METHODS: Twenty consecutive patients (14 male, 6 female; mean age 23.3 +/- 13.4 years) suffering from osteoid osteoma underwent unenhanced and contrast-enhanced T1-weighted MRI the day after  RFA. Post-interventional contrast enhancement of the nidus was analyzed by comparing signal-to-noise ratios (SNR) of the nidus before and after contrast administration. The SNR between pre- and post-contrast scans was computed. RESULTS: There were no significant differences in SNR between pre- and post-contrast scans in the area of ablation (P = 0.1583), while the SNR exceeded  one in four patients, indicating residual contrast enhancement. In three of these patients clinical symptoms recurred, requiring re-ablation, while one patient remained free from symptoms during follow-up. In patients with a pre- and post-contrast SNR of </= 1.18 no local recurrence was observed. CONCLUSIONS: Contrast enhancement on T1-weighted MRI imaging seems to be predictive of clinically unsuccessful RFA in osteoid osteoma. Patients with a SNR increase of >/= 20% after contrast administration might be considered for re-ablation to avoid symptomatic tumour recurrence.

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[576]

TÍTULO / TITLE:  - Disseminated bone lesions in AIDS-associated Kaposi sarcoma, a bad prognosis? About four cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Int AIDS Soc. 2012 Nov 11;15(6):18437. doi: 10.7448/IAS.15.6.18437.

AUTORES / AUTHORS:  - Wassilew N; Ciaffi L; Vu D; Calmy A; Toutous Trellu L

INSTITUCIÓN / INSTITUTION:  - University Hospital Geneva, Infectious Diseases, Geneva, Switzerland.

RESUMEN / SUMMARY:  - Kaposi sarcoma (KS) can present with a wide range of clinical features ranging from minimal cutaneous disease to a rapidly progressing neoplasm. Bone lesions are most often discovered accidently in the context of radiological investigations done for the screening of KS-visceral involvement [1]. Little is known on clinical outcome and response to antiretroviral therapy (ART) and/or chemotherapy of these lytic osseous lesions. We report four cases with bone involvement in the context of systemic KS and aim at describing the long-term clinical outcome in two of these patients. Cases of AIDS-associated KS with disseminated bone lesions were collected in the HIV Unit, University Hospital Geneva, Switzerland. Patients were compared on clinical, biological and radiological features and therapeutic responses. Between 2002 and 2012, four HIV1-infected patients with T1 stage of KS presented disseminated osseous lesions (Table 1). Mean age was 43 years (range 39 - 47 years), mean time of follow up until our analysis was 48.5 months (SD 53.8), and mean CD4 count at KS diagnosis  was 190.5 c/mL (SD 202.8). All patients showed hypodense bone lesions predominating the axial skeleton (Figure 1), but no radiological imaging was performed to search for peripheral bone lesions.No patient reported pain or experienced pathological fractures. In one patient a dual-energy X-ray absorptiometry (DXA) showed a bone mineral density within normal range after 10 years of KS diagnosis with disseminated bone lesions. No radiological change was  observed in that patient despite stable KS disease after 13 cycles of liposomal doxorubicin and ART (Figure 1). We describe a well-documented long-term follow up of disseminated osseous AIDS-associated KS disease. In our four cases, lytic bone lesions were asymptomatic and were not associated with bone fragility. We even could confirm the KS nature of the lesions by bone biopsy in patient B (3 months  after KS diagnosis), as the differential diagnosis is wide, and include bacillary angiomatosis, cancers or metastasis. Chemotherapy and antiretroviral treatment did not affect bone lesions using CT scan despite a good response on other KS-affected sites. Prognostic factors are well established in AIDS-associated KS  [2]; however disseminated bone disease does not seem to have an impact on disease evolution. A larger sample size is needed to confirm this hypothesis.

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[577]

TÍTULO / TITLE:  - Radiation-induced high-grade spindle cell sarcoma of the sternomastoid muscle: a  case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Head Neck Oncol. 2012 Oct 15;4(3):68.

AUTORES / AUTHORS:  - Hamdoon Z; Jerjes W; Al-Delayme R; Upile T; Vaz F

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Al-Yarmouk University College, Baghdad, Iraq. Unit of Oral and Maxillofacial Surgery, UCL Eastman Dental Institute, London, UK. Department of Oral and Maxillofacial Surgery, University of Mosul, Mosul, Iraq. zaid19772000@yahoo.com.

RESUMEN / SUMMARY:  - Sarcomas developing as primary malignancies of the head and neck are a rare complication after radiation therapy. This kind of sarcoma has variable clinicopathological appearances and behaviour. Radiation-induced spindle cell rhabdomyosarcoma of the sternomastoid muscle is a very rare sarcoma and has very  seldom been described in the literature. Herein, we report on the development of  a rapidly growing mass over the lateral side of the neck appearing after 7 years  in a patient with a history of laryngeal carcinoma who received radiotherapy and  chemotherapy. The process of diagnosis and management using combined surgery and  targeted brachytherapy are discussed. The patient experienced discomfort and oozing of the wound for up to 2 months after surgery; however, complete response  with satisfactory adaptation and shrinkage of the pectoralis major pedicled muscle flap occurred after a year. The patient has been disease-free for 5 years  post-operation. Radiation-induced spindle cell rhabdomyosarcoma of the sternomastoid muscle after treatment for laryngeal carcinoma may occur a long time after radiation therapy and be clinically aggressive, radiographically distinctive and require multidisciplinary management.

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[578]

TÍTULO / TITLE:  - Pregnancy with Metastatic Gastrointestinal Stromal Tumor (GIST) on Imatinib Chemotherapy: an Oncologist’s Nightmare and Obstetrician’s Dilemma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Cancer. 2012 Dec 6.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12029-012-9464-4

AUTORES / AUTHORS:  - Goel N; Malik R; Rathi B; Bhaskaran S; Rajaram S; Mehta S; Agarwal N

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095, India.

RESUMEN / SUMMARY:  - INTRODUCTION: Gastrointestinal stromal tumors (GISTs) are among the few cancers amenable to successful treatment by targeted molecular therapy with KIT receptor  inhibitors like imatinib mesylate. Increasing incidence of this tumor and its successful treatment has given rise to issues of fertility and child bearing in patients affected at young age. Although contraception advice and termination of  early pregnancy have been the standard practice in patients on such therapy, an occasional patient who desires pregnancy can leave both obstetrician and oncologist perplexed. CLINICAL PRESENTATION: We report our experience in a rare patient of metastatic GIST who had a successful normal pregnancy while on imatinib therapy. We further attempt to evaluate similar evidence in literature.

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[579]

TÍTULO / TITLE:  - Diagnosis and management of nonsyndromic hereditary gingival fibromatosis in a 13 year old girl: Report of a rare case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Contemp Clin Dent. 2012 Sep;3(Suppl 2):S210-3. doi: 10.4103/0976-237X.101097.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0976-237X.101097

AUTORES / AUTHORS:  - Goyal L; Bey A; Gupta ND; Varshney A

INSTITUCIÓN / INSTITUTION:  - Department of Periodontics and Community Dentistry, Dr. Z. A. Dental College, Aligarh Muslim University, Aligarh, India.

RESUMEN / SUMMARY:  - Hereditary gingival fibromatosis is a rare condition characterized by various degree of gingival overgrowth. It usually develops as an isolated disorder but can manifest with multisystem syndrome. We are here presenting a case of a 13-year-old girl who presented with severe enlargement of gingiva covering all most the entire crown involving both maxillary and mandibular arches. Differential diagnosis includes drug-induced and idiopathic gingival enlargement. Excess gingival tissue was removed by full mouth gingivectomy and sent for histopathological examination. Postoperative course was uneventful and patient’s  esthetics improved significantly. A 12 month postoperative period shows no recurrence.

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[580]

TÍTULO / TITLE:  - Sarcoma in the thymus of juvenile meagre Argyrosomus regius reared in an intensive system.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Dis Aquat Organ. 2012 Dec 27;102(2):119-27. doi: 10.3354/dao02545.

            ●● Enlace al texto completo (gratuito o de pago) 3354/dao02545

AUTORES / AUTHORS:  - Soares F; Leitao A; Moreira M; de Sousa JT; Almeida AC; Barata M; Feist SW; Pousao-Ferreira P; Ribeiro L

INSTITUCIÓN / INSTITUTION:  - IPMA, Av. 5 de Outubro s/n 8700-305 Olhao, Portugal.

RESUMEN / SUMMARY:  - Juvenile meagre Argyrosomus regius (Asso, 1809) maintained in experimental conditions developed lateral and/or bilateral circular-shaped sarcoma within the  opercular cavity. The sarcoma was dense, reddish and its growth from the branchial arch exerted pressure on the operculum forcing it to open. Histologically, the neoplasm exhibited marked proliferation of mesenchymal connective tissue composed largely of fusiform cells, which developed in a solid  pattern accompanied by abundant mononuclear cell types. Multifocal areas of discrete necrosis were also observed, compatible with a sarcomatous proliferation. The immunological parameters analysed suggested an inflammatory response. No bacteria were isolated from the hematopoietic organs. However, Vibrio species, components of the normal seawater flora, were isolated from the tumour, which may have had a role in eliciting the immune response. No evidence of viral pathogens was found by electron microscopy. In order to look for cytogenetic alterations often linked to sarcomas, the diploid number and karyotype of this species were determined for the first time. An increase in the  aneuploidy level was observed in sarcoma cell metaphase stages compared to other  tissues. The aetiology of this tumour remains unknown.

 

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[581]

TÍTULO / TITLE:  - Expression and anatomical distribution of TIM-containing molecules in Langerhans  cell sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Mol Histol. 2012 Dec 21.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10735-012-9475-2

AUTORES / AUTHORS:  - Li J; Cao D; Guo G; Wu Y; Chen Y

INSTITUCIÓN / INSTITUTION:  - Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, People’s Republic of China.

RESUMEN / SUMMARY:  - Signals from the T cell immunoglobulin and mucin-domain (TIM)-containing molecules have been demonstrated to be involved in regulating the progress of carcinoma. However, the expression and anatomical distribution of TIMs in Langerhans cell sarcoma (LCS), which is a rare malignancy derived from dendritic  cells of the epidermis, has yet to be determined. In this study, the expression of TIM-1, TIM-3 and TIM-4 in LCS samples were detected by immunohistochemistry. Our results showed that these three molecules were found in LCS sections. At the  cellular level, these molecules were found on the cell membrane and in the cytoplasm. Immunofluorescence double-staining demonstrated that these TIMs were co-expressed with Langerin, a potential biomarker for detecting LCS. In addition, TIM-1 was also expressed on CD68(+) macrophages and CK-18(+) epithelial cells, while TIM-3 and TIM-4 were expressed on all cell types investigated, including CD3(+)T cells, CD68(+) macrophages, CD11c(+) dendritic cells, CD16(+) NK Cells, CD31(+) endothelial cells and CK-18(+) epithelial cells. Interestingly, TIMs were also co-expressed with some members of the B7 superfamily, including B7-H1, B7-H3 and B7-H4 on sarcoma cells. Our results clearly showed the characteristic expression and anatomical distribution of TIMs in LCS, and a clear understanding  of their functional roles may further elucidate the pathogenesis of this carcinoma and potentially contribute to the development of novel immunotherapeutic strategies.

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[582]

TÍTULO / TITLE:  - Erratum to: Oral and Maxillofacial Sclerosing Epithelioid Fibrosarcoma: Report of Five Cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Head Neck Pathol. 2012 Dec 15.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12105-012-0410-3

AUTORES / AUTHORS:  - Folk GS; Williams SB; Foss RB; Fanburg-Smith JC

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Naval Medical Center San Diego, San Diego, CA, USA, gretchen.folk@med.navy.mil.

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[583]

TÍTULO / TITLE:  - Locally invasive pulmonary inflammatory myofibroblastic tumors in children.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Indian Assoc Pediatr Surg. 2012 Oct;17(4):184-5. doi: 10.4103/0971-9261.102346.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0971-9261.102346

AUTORES / AUTHORS:  - Menon P

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Surgery, Postgraduate Institute of Medical Education and  Research, Chandigarh, India.

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[584]

TÍTULO / TITLE:  - Middle ear rhabdomyosarcoma infiltrating the petrous with diffuse leptomeningeal  spread in a child.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Neurosci. 2012 May;7(2):103-5. doi: 10.4103/1817-1745.102567.

            ●● Enlace al texto completo (gratuito o de pago) 4103/1817-1745.102567

AUTORES / AUTHORS:  - Salunke P; Sura S; Gupta K; Tripathi M; Aggarwal A

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, PGIMER, Chandigarh, India.

RESUMEN / SUMMARY:  - We present a case of middle ear rhabdomyosarcoma with intracranial erosion and later presented with diffuse leptomeningeal spread. Such lesions are difficult to eradicate and have a poor prognosis.

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[585]

TÍTULO / TITLE:  - Proximal-type epithelioid sarcoma-a rare soft tissue sarcoma of thigh in a child.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):298-301. doi: 10.1007/s13193-012-0147-1. Epub  2012 Apr 3.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-012-0147-1

AUTORES / AUTHORS:  - Naik D; Kumar AA; Srinath MG

INSTITUCIÓN / INSTITUTION:  - Department of Radiodiagnosis and Imaging, M.S. Ramaiah Medical College, MSR Nagar, MSRIT Post, Bangalore, 560054 India ; Department of Radiodiagnosis, M.S. Ramaiah Medical College, MSR Nagar, MSRIT Post, Bangalore, 560054 India.

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[586]

TÍTULO / TITLE:  - Molecular characterisation of gastrointestinal stromal tumours in a South African population.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Jan;5(1):155-160. Epub 2012 Nov 5.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1013

AUTORES / AUTHORS:  - Baker G; Babb C; Schnugh D; Nayler S; Louw M; Goedhals J; Bringuier PP; Blay JY; Willem P

INSTITUCIÓN / INSTITUTION:  - Department of Molecular Medicine and Haematology, Faculty of Health Sciences, National Health Laboratory Services and University of the Witwatersrand;

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours  of the digestive tract. Pathogenesis is linked to activating mutations identified in two proto-oncogenes, v-kit Hardy/Zuckerman 4 feline sarcoma viral oncogene homologue KIT (KIT) and the platelet-derived growth factor alpha (PDGFRalpha). In addition, these mutations affect response to treatment with tyrosine kinase inhibitors. In the present study, we report on the molecular characterisation of  GISTs in the South African population. Tumour DNA was extracted from 46 GIST samples, followed by cycle sequencing of KIT exons 11, 13 and 17 and PDGFRalpha exons 12, 14 and 18. Fragment length analysis was used to detect a 6-bp duplication in KIT exon 9. Wild-type duplications were analysed further by PCR and sequencing of additional KIT and PDGFRalpha exons was performed. Overall, 78.3% of the samples had a mutation in KIT or PDGFRalpha. Of these, mutations were detected in KIT exon 11 (88.9%), PDGFRalpha exon 18 (8.3%) and KIT exon 9 (2.8%). Mutations varied from simple substitutions and duplications to large deletions (some with nucleotide insertions) resulting in missense mutations. In addition, seven single nucleotide polymorphisms were detected in 17 patients, one of which appears novel. The incidence of mutations in KIT exon 11 and PDGFRalpha  exon 18 is consistent with the literature, however, the low incidence of KIT exon 9 mutations detected was unexpected. In contrast to previous western and Asian studies, this mutation appears to be rare in the South African population. The present study contributes to the molecular understanding of GISTs in the South African population.

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[587]

TÍTULO / TITLE:  - A rare case of primary parapharyngeal well differentiated liposarcoma with rhabdomyoblastic differentiation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Diagn Res. 2012 Nov;6(9):1557-8. doi: 10.7860/JCDR/2012/4231.2560.

            ●● Enlace al texto completo (gratuito o de pago) 7860/JCDR/2012/4231.2560

AUTORES / AUTHORS:  - V G; N B; K R

INSTITUCIÓN / INSTITUTION:  - Additional Professor of Pathology, KMC, Manipal University , Manipal, India.

RESUMEN / SUMMARY:  - Rhabdomyoblastic differentiation in liposarcoma is a rare entity, with only few cases being reported in the literature. These cases were reported in either dedifferentiated liposarcomas or in recurrent tumours which occurred in the retroperitoneum. The present case was a rare case of a primary parapharyngeal well differentiated liposarcoma with a focal rhabdomyoblastic differentiation.

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[588]

TÍTULO / TITLE:  - Intracoelomic anaplastic sarcoma in an intersex Madagascar tree boa (Sanzinia madagascariensis).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Vet Diagn Invest. 2013 Jan;25(1):153-7. doi: 10.1177/1040638712468432.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1040638712468432

AUTORES / AUTHORS:  - Sharpe S; Lamm CG; Killick R

INSTITUCIÓN / INSTITUTION:  - 1Catherine G. Lamm, IDEXX Laboratories, 2825 KOVR Drive, West Sacramento, CA 95605. Catherine-Lamm@idexx.com.

RESUMEN / SUMMARY:  - An adult Madagascar tree boa (Sanzinia madagascariensis) underwent coeliotomy for investigation of a coelomic mass. At surgery, a large mass originating from the peri-pancreatic adipose tissue and involving the gall bladder was removed. The snake did not recover from general anesthesia. A complete postmortem was performed, and samples were submitted to the University of Glasgow for histopathology. On histological examination, the mass was composed of adipose tissue infiltrated with a poorly demarcated spindle cell neoplasm. The neoplastic cells were highly pleomorphic with abundant cytoplasm and frequent clear cytoplasmic vacuoles, suggestive of adipocyte origin. Immunohistochemical characterization of the mass was inconclusive. Metastatic neoplastic cells were present within vessels in the liver, lungs, and brain. As an incidental finding,  the gonads contained both maturing ovarian follicles and seminiferous tubules with intact germinal epithelium and evidence of spermatogenesis, along with other features of male and female gonad anatomy. The current report describes a rare neoplasm in snakes within an intersex Madagascar tree boa.

 

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[589]

TÍTULO / TITLE:  - Expression of antigen tf and galectin-3 in fibroadenoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - BMC Res Notes. 2012 Dec 24;5:694. doi: 10.1186/1756-0500-5-694.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1756-0500-5-694

AUTORES / AUTHORS:  - Gallegos IB; Perez-Campos E; Martinez M; Mayoral MA; Perez L; Aguilar S; Zenteno E; Pina Mdel S; Hernandez P

INSTITUCIÓN / INSTITUTION:  - Centro de Investigaciones en Ciencias Medicas y Biologicas Facultad de Medicina,  Universidad Autonoma Benito Juarez de Oaxaca, 68020, Oaxaca, Mexico. fuegoblanco136@yahoo.com.mx.

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: Fibroadenomas are benign human breast tumors, characterized by proliferation of epithelial and stromal components of the terminal ductal unit. They may grow, regress or remain unchanged, as the hormonal environment of  the patient changes. Expression of antigen TF in mucin or mucin-type glycoproteins and of galectin-3 seems to contribute to proliferation and transformations events; their expression has been reported in ductal breast cancer and in aggressive tumors. FINDINGS: Lectin histochemistry, immunohistochemistry, and immunofluorescence were used to examine the expression  and distribution of antigen TF and galectin-3. We used lectins from Arachis hypogaea, Artocarpus integrifolia, and Amaranthus lecuocarpus to evaluate TF expression and a monoclonal antibody to evaluate galectin-3 expression. We used paraffin-embedded blocks from 10 breast tissues diagnosed with fibroadenoma and as control 10 healthy tissue samples. Histochemical and immunofluorescence analysis showed positive expression of galectin-3 in fibroadenoma tissue, mainly  in stroma, weak interaction in ducts was observed; whereas, in healthy tissue samples the staining was also weak in ducts. Lectins from A. leucocarpus and A. integrifolia specificaly recognized ducts in healthy breast samples, whereas the  lectin from A. hypogaea recognized ducts and stroma. In fibroadenoma tissue, the  lectins from A. integrifolia, A. Hypogaea, and A. leucocarpus recognized mainly ducts. CONCLUSIONS: Our results suggest that expression of antigen TF and galectin-3 seems to participate in fibroadenoma development.

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[590]

TÍTULO / TITLE:  - Two huge maxillofacial osteoma cases evaluated by computed tomography.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Iran J Radiol. 2011 Dec;8(4):253-7. doi: 10.5812/iranjradiol.4588. Epub 2011 Dec  25.

            ●● Enlace al texto completo (gratuito o de pago) 5812/iranjradiol.4588

AUTORES / AUTHORS:  - Saati S; Nikkerdar N; Golshah A

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Radiology, School of Dentistry, Boali University of Medical Sciences, Hamedan, Iran.

RESUMEN / SUMMARY:  - Osteomas are benign osteogenic neoplasms or hamartomas with a very slow growth rate. Osteoma is the most common mesenchymal neoplasm of the paranasal sinuses. In the jaws, the mandible is more commonly involved than the maxilla. Osteomas may occur at any age, but most frequently are found in individuals older than 40  years. Although most osteomas are small, some may become large enough to cause severe damage, especially those that develop in the frontoethmoid region. Osteomas composed solely of compact bone are uniformly radiopaque and those containing cancellous bone show evidence of internal trabecular structure. To determine and evaluate the exact extension and internal structure of these lesions, computed tomography (CT) is a more useful imaging modality in comparison to conventional radiography. Hereby, we discuss clinical and imaging features of  two osteomas (one in the ethmoid sinus and the other in the mandible) along with  the main differential diagnoses and pathologic features.

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[591]

TÍTULO / TITLE:  - Primary ewings sarcoma of cavernous sinus in an infant: a case report and review  of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Turk Neurosurg. 2013;23(1):98-103. doi: 10.5137/1019-5149.JTN.4131-11.1.

            ●● Enlace al texto completo (gratuito o de pago) 5137/1019-5149.JTN.4131-11.1

AUTORES / AUTHORS:  - Patibandla MR; Uppin SG; Thotakura AK; Panigrahi MK; Challa S

INSTITUCIÓN / INSTITUTION:  - Nizam’s Institute of Medical Sciences, Department of Neurosurgery, Hyderabad, India.

RESUMEN / SUMMARY:  - Ewing’s / peripheral primitive neuroectodermal tumor (pPNET) of the cavernous sinus are extremely uncommon. We present clinical, radiological, pathological findings of Ewing’s / pPNET involving the cavernous sinus in an eleven-month-old  infant presenting with proptosis and 6th nerve palsy. MRI Contrast scans showed a well-defined, homogenously enhancing mass involving the right cavernous sinus location. Histopathology and immunohistochemical features were consistent with Ewing’s/pPNET. The patient succumbed to disease in spite of starting chemotherapy. The clinical, radiological and pathological findings of previously  reported cases of Ewing’s sarcoma / pPNET involving the cavernous sinus are summarized. The histological differential diagnosis of primary intracranial Ewing’s sarcoma / pPNET are discussed.

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[592]

TÍTULO / TITLE:  - Small Bowel Intussusception due to Metastasized Sarcomatoid Carcinoma of the Lung: A Rare Cause of Intestinal Obstruction in Adults.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Surg. 2012;2012:962683. doi: 10.1155/2012/962683. Epub 2012 Dec 30.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/962683

AUTORES / AUTHORS:  - Guner A; Karyagar S; Livaoglu A; Kece C; Kucuktulu U

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, Trabzon Kanuni Training and Research Hospital, 61040 Trabzon, Turkey.

RESUMEN / SUMMARY:  - Although small bowel intussusception is one of the most common abdominal emergencies in childhood, it is rare in adults and usually occurs as a result of  an underlying pathology. Sarcomatoid carcinoma, a very rare subtype of lung cancer, rarely metastasizes to small bowel and causes complications. In this paper, we aim to describe a patient with small bowel intussusception caused by an isolated small bowel metastasis of the sarcomatoid carcinoma of the lung by reviewing the literature.

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[593]

TÍTULO / TITLE:  - FDG PET/CT in Initial Staging of Adult Soft-Tissue Sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2012;2012:960194. doi: 10.1155/2012/960194. Epub 2012 Dec 2.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/960194

AUTORES / AUTHORS:  - Roberge D; Vakilian S; Alabed YZ; Turcotte RE; Freeman CR; Hickeson M

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, McGill University Health Centre, 1650 Cedar Avenue, Montreal, QC, Canada H3G 1A4 ; Department of Radiation Oncology, Notre-Dame Hospital, CHUM, 1560 Sherbrooke Street East, Montreal, QC, Canada H2L  4M1.

RESUMEN / SUMMARY:  - Soft-tissue sarcomas spread predominantly to the lung and it is unclear how often FDG-PET scans will detect metastases not already obvious by chest CT scan or clinical examination. Adult limb and body wall soft-tissue sarcoma cases were identified retrospectively. Ewing’s sarcoma, rhabdomyosarcoma, GIST, desmoid tumors, visceral tumors, bone tumors, and retroperitoneal sarcomas were excluded  as were patients imaged for followup, response assessment, or recurrence. All patients had a diagnostic chest CT scan. 109 patients met these criteria, 87% of  which had intermediate or high-grade tumors. The most common pathological diagnoses were leiomyosarcoma (17%), liposarcoma (17%), and undifferentiated or pleomorphic sarcoma (16%). 98% of previously unresected primary tumors were FDG avid. PET scans were negative for distant disease in 91/109 cases. The negative predictive value was 89%. Fourteen PET scans were positive. Of these, 6 patients  were already known to have metastases, 3 were false positives, and 5 represented  new findings of metastasis (positive predictive value 79%). In total, 5 patients  were upstaged by FDG-PET (4.5%). Although PET scans may be of use in specific circumstances, routine use of FDG PET imaging as part of the initial staging of soft-tissue sarcomas was unlikely to alter management in our series.

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[594]

TÍTULO / TITLE:  - Rhabdomyosarcoma in an adult hand.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Plast Surg Hand Surg. 2013 Jan 29.

            ●● Enlace al texto completo (gratuito o de pago) 3109/2000656X.2012.731580

AUTORES / AUTHORS:  - Seyhan N; Keskin M; Tosun Z; Savaci N

INSTITUCIÓN / INSTITUTION:  - Department of Plastic and Reconstructive Surgery, Meram Medical School.

RESUMEN / SUMMARY:  - Abstract Rhabdomyosarcoma (RMS) is a malign tumour which arises from cells committed to a skeletal muscle lineage. It constitutes 4%-8% of all childhood malignancies but is rare in adults. The rare pleomorphic subtype occurs almost exclusively in adults and most often involves the extremities. RMS of the hand or foot comprise a minority of extremity cases. An adult patient with rhabdomyosarcoma in the hand, which is very rare, is presented in this article. General characteristics of the tumour and the treatment strategies are discussed.

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[595]

TÍTULO / TITLE:  - Retroperitoneal synovial sarcoma manifested by obstructive jaundice in an elderly woman: case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Endosc. 2012 Nov;45(4):428-30. doi: 10.5946/ce.2012.45.4.428. Epub 2012 Nov  30.

            ●● Enlace al texto completo (gratuito o de pago) 5946/ce.2012.45.4.428

AUTORES / AUTHORS:  - Kim DH; Joo KR; Cha JM; Shin HP; Lee JI; Park JJ; Kim HS; Yang DM

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, Kyung Hee University Hospital at Gangdong, Kyung  Hee University School of Medicine, Seoul, Korea.

RESUMEN / SUMMARY:  - Synovial sarcoma is a rare type of soft tissue sarcoma that arises in tissues containing synovial fluid, usually in the extremities. It has only rare occurrence in the retroperitoneal space. Early detection of retroperitoneal synovial sarcoma is difficult, since the retroperitoneal space is highly expandable and deeply hidden. Furthermore, the presenting symptoms are often vague and nonspecific, and are related to the pressure on adjacent structures. In this study, we present an unusual case of retroperitoneal synovial sarcoma with obstructive jaundice due to intrabiliary blood clots caused by invasion of bile duct by tumor. The obstructive jaundice was relieved through endoscopic removal of the blood clots and insertion of a biliary stent.

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[596]

TÍTULO / TITLE:  - Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion) of the Hand: A Report of Two Atypical Cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Report Med. 2012;2012:453560. doi: 10.1155/2012/453560. Epub 2012 Dec 25.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/453560

AUTORES / AUTHORS:  - Barrera-Ochoa S; Lluch A; Gargallo-Margarit A; Perez M; Velez R

INSTITUCIÓN / INSTITUTION:  - Orthopaedic Surgery and Traumatology Department, Hospital Universitari Vall d’Hebron, Passeig Vall d’Hebron 119-129, 08035 Barcelona, España.

RESUMEN / SUMMARY:  - Bizarre parosteal osteochondromatous proliferation (BPOP), also called Nora’s lesion, is an unusual, benign, bony lesion frequently found in the hand. Originally, two of the key radiological features used to describe such lesions were: (1) a lack of corticomedullar continuity and (2) an origin from the periosteal aspect of an intact cortex. The authors present 2 unique cases of histologically proven BPOP in which the integrity of the cortex was affected. In  the first case there was medullary continuity, and in the second case there was saucerization of the underlying cortical bone. The authors support that simple X-ray evaluation is insufficient to diagnose BPOP in atypical cases. Careful axial CT scanning or MRI may prove helpful. Taking into account these new notions, histopathology gains greater importance as a diagnostic tool for this particular group of entities.

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[597]

TÍTULO / TITLE:  - A case of parosteal osteosarcoma with a rare complication of myositis ossificans.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2012 Nov 29;10:260. doi: 10.1186/1477-7819-10-260.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-10-260

AUTORES / AUTHORS:  - Spinelli MS; Perisano C; Rocca CD; Hardes J; Barone C; Fabbriciani C; Maccauro G

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics and Traumatology, Catholic University Hospital “Agostino Gemelli”, L,go A, Gemelli, 1-00168 Rome, Italy. msilviaspinelli@yahoo.it.

RESUMEN / SUMMARY:  - ABSTRACT: We report the case of a parosteal osteosarcoma of the distal ulna, treated with wide resection without reconstruction. The patient developed lung metastasis and a mass in the interosseus membrane of the forearm proximally to the osteotomy. The lung mass was found to be a metastasis from parosteal osteosarcoma and the biopsy of the forearm mass revealed a myositis ossificans. The suspicion of a recurrence of parosteal osteosarcoma, already metastatic, led  to a second wide resection with no reconstruction. A slice of the radial cortex was taken during this second procedure. From a histological point of view, good margins were achieved and diagnosis of myositis ossificans was confirmed. Two months later, a radius fracture occurred and a synthesis, with plate and screws,  as added with poly(methyl methacrylate) (PMMA) to reconstruct the bone loss, was  performed. Indication of the reconstructive technique and the complication after  distal ulna resection in oncologic surgery are discussed in this paper.

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[598]

TÍTULO / TITLE:  - A Rare Case of Recurrent Frontal Osteoma complicated by Mucopyocele with an Unusual Organism, Moraxella Catarrhalis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World Neurosurg. 2012 Nov 29. pii: S1878-8750(12)01364-2. doi: 10.1016/j.wneu.2012.11.064.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.wneu.2012.11.064

AUTORES / AUTHORS:  - Ramakrishna R; Nair MN; Huber B; Sekhar LN

INSTITUCIÓN / INSTITUTION:  - Departments of Neurological Surgery and Pathology, University of Washington. Electronic address: rohan.ramakrishna@gmail.com.

RESUMEN / SUMMARY:  - OBJECTIVE: We report a rare case of recurrent frontal osteoma complicated by mucopyocele and intracranial abscess. Furthermore, we report an unusual organism, Moraxella Catarrhalis as the infectious agent. Finally, we demonstrate that endovascular embolization may be part of the treatment paradigm of frontal osteomas in selected cases. CLINICAL PRESENTATION: A 71 year old man with a previous history of craniotomy presented to the emergency room with 24 hours of headaches confusion, lethargy and low grade fevers. Imaging and Angiography revealed a complex frontal lesion involving the fronto-ethmoidal sinuses that extended into the medial orbit and anterior skull base with multiple feeding vessels from the middle meningeal artery. INTERVENTION: The initial diagnosis of  recurrent meningioma was made based on imaging data. The patient underwent partial angiographic embolization of the lesion followed by microneurosurgical complete resection. Pathology revealed a synchronous presentation of an osteoma and mucopyocele with intracranial abscess caused by Moraxella Catarrhalis. CONCLUSION: Synchronous presentation of a frontal osteoma with mucopyocele is a rare event. However, the case of a recurrent osteoma complicated by infection with Moraxella Catarhalis has not been reported in the literature, nor a treatment paradigm that included preoperative partial endovascular embolization.

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[599]

TÍTULO / TITLE:  - An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Case Rep. 2013 Jan 24;7(1):30.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1752-1947-7-30

AUTORES / AUTHORS:  - Wang LL; Xie H; Fu HL; Jiang S; Wang XF; Jia MZ; Liu ZH; Zhao YP

RESUMEN / SUMMARY:  - ABSTRACT: INTRODUCTION: Malignant fibrous histiocytoma is a very common subtype of soft-tissue sarcoma in middle and late adulthood. However, malignant fibrous histiocytoma of the testis is very rare in adolescents. CASE PRESENTATION: We report here the case of a 14-year-old Han Chinese boy, who presented with left scrotal mass lasting for 20 days along with distending pain for 5 days. A physical examination revealed a chicken egg-sized, firm, well-defined mass and unclear epididymis. A B-scan ultrasonography of the left scrotum displayed a 9.0x5.2x4.5cm medium- or low-echoic lobulated mass, which suggested a left testicular neoplasm. A fine needle aspiration cytology examination revealed that  the cells obtained from the patient’s testicular neoplasm were composed of myxoid spindle, and ovoid cells with nuclear atypia and mitotic activity, and arranged in a whirlpool or storiform pattern. Under histological examination, the tumor cells were arranged in a storiform pattern, which displayed mucoid matrix degeneration, and grew invasively. Consequently, a histopathological diagnosis suggested myxofibrosarcoma (or myxoid malignant fibrous histiocytoma). CONCLUSIONS: An ultrasonic examination combined with fine needle aspiration cytology should be helpful for the initial differential diagnosis of testicular malignant fibrous histiocytoma. However, the final confirmation relies on histopathological examination. To the best of our knowledge, this is the first reported case of malignant fibrous histiocytoma of the testis in an adolescent.

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[600]

TÍTULO / TITLE:  - Short-term advantages of laparoscopic uterine vessel occlusion in the management  of women with symptomatic myoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Taiwan J Obstet Gynecol. 2012 Dec;51(4):539-44. doi: 10.1016/j.tjog.2012.09.008.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.tjog.2012.09.008

AUTORES / AUTHORS:  - Wang KC; Chang WH; Liu WM; Yen YK; Huang N; Wang PH

INSTITUCIÓN / INSTITUTION:  - Department of Nursing, Oriental Institute of Technology, New Taipei City, Taiwan.

RESUMEN / SUMMARY:  - OBJECTIVE: The aim of this study was to evaluate the short-term therapeutic outcome of women with symptomatic uterine myomas treated with laparoscopic uterine vessel occlusion (LUVO) or laparoscopic myomectomy (LM). METHODS: Ninety-five patients with symptomatic, uncomplicated myomas warranting surgical treatment who expressed a strong desire to retain their uterus were included in this study. Fifty-two patients underwent LUVO and 43 underwent LM. The outcome was measured by comparing blood loss, surgical time, postoperative recovery, postoperative pain (visual analog scale), complications, and success rate in both groups. RESULTS: The general characteristics of the patients were similar in both groups. There were no statistical differences in febrile morbidity, complications, success rate, therapeutic efficacy (symptom relief), and satisfaction rate between the two groups. LUVO had advantages over LM, including  less surgical time, minimal blood loss, lower visual analog scale score, and rapid postoperative recovery. CONCLUSIONS: Both LUVO and LM might be effective in the management of symptomatic myomas in selected cases, but LUVO seemed to be more acceptable and less invasive in this 1-year short-term follow-up.

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[601]

TÍTULO / TITLE:  - Abdominoplasty and thoraco-epigastric flaps for large anterior trunk defects after dermatofibrosarcoma protuberans wide resection: Two illustrative cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Case Rep. 2013;4(1):134-8. doi: 10.1016/j.ijscr.2012.11.002. Epub 2012 Nov 10.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2012.11.002

AUTORES / AUTHORS:  - Casal D; Fradinho N; Ramos L; Ferreira J; Varanda A; Diogo C; Baltazar J; Fernandes M; Correia C; Almeida MA

INSTITUCIÓN / INSTITUTION:  - Sao Jose Hospital, Lisbon, Portugal. Electronic address: diogo_bogalhao@yahoo.co.uk.

RESUMEN / SUMMARY:  - INTRODUCTION: Excision of large dermatofibrosarcoma protuberans in the anterior aspect of the trunk often results in large surgical defects that frequently dictate the need for microsurgical reconstruction. However, this option is not always available. PRESENTATION OF CASE: The authors describe two patients with very large anterior trunk dermatofibrosarcoma protuberans: one in the epigastric  region and the other in the hypogastric region. In the patient with the hypogastric tumor, a classical abdominoplasty flap associated with umbilical transposition was used to cover the skin defect after muscle and fascial plication, and placement of a polypropylene mesh. In the patient with the epigastric tumor, a synthetic mesh was also placed, and the skin and subcutaneous defect was reconstructed with a reverse abdominoplasty flap and two thoraco-epigastric flaps. In both cases, complete closure was possible without immediate or late complications. DISCUSSION: The local options described in this  paper present several potential advantages compared to microsurgical reconstruction, namely they are easier and faster to perform and teach; they provide a good skin color and texture match; they are not associated with distant donor site morbidity; follow-up is usually less cumbersome; the post-operative hospital stay tends to be shorter; they are less costly; they are less prone to complete failure. CONCLUSION: The authors believe that these two patients clearly show that local flaps, although frequently neglected, continue to be valid options for reconstructing large anterior trunk defects, even in the current era  of microsurgery enthusiasm.

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[602]

TÍTULO / TITLE:  - An endobronchial lipoma successfully resected by high-frequency electric snare: a report of 2 cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Bronchology Interv Pulmonol. 2012 Jan;19(1):68-71. doi: 10.1097/LBR.0b013e31823fa944.

            ●● Enlace al texto completo (gratuito o de pago) 1097/LBR.0b013e31823fa944

AUTORES / AUTHORS:  - Shinohara S; Hanagiri T; Takenaka M; Oka S; Chikaishi Y; Shigematsu Y; Nagata Y; Shimokawa H; Nakagawa M; Uramoto H; So T; Tanaka F

INSTITUCIÓN / INSTITUTION:  - Second Department of Surgery, School of Medicine, University of Occupational and  Environmental Health, Kitakyushu, Japan.

RESUMEN / SUMMARY:  - Endobronchial lipoma is a rare, benign disease. When it causes chronic cough and  pneumonia due to obstruction of the central airway, appropriate treatment is required. We herein report 2 cases of endobronchial lipoma successfully treated with a high-frequency electric snare through a flexible bronchoscope. Case 1, an  83-year-old man, visited a nearby hospital because of dyspnea on exertion. Chest  computerized tomography revealed a tumor in the right main bronchus. He was referred to our hospital for further examination and treatment. Bronchoscopy showed a polypoid lesion in the right main bronchus. The tumor was resected by high-frequency electric snare through a flexible bronchoscope. Case 2 was an 83-year-old man who was diagnosed with pneumonia by a primary care physician on the basis of findings on chest computerized tomography. Bronchoscopy showed a polypoid lesion at the orifice of the right B6 bronchus, which caused segmental obstructive pneumonia. The tumor was bronchoscopically resected using a high-frequency electric snare and an neodymium-yttrium-aluminum-garnet laser. In  both cases, the pathologic diagnosis was endobronchial lipoma.

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[603]

TÍTULO / TITLE:  - A population-based study of Kaposi Sarcoma-associated herpesvirus seropositivity  in Uganda using principal components analysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Infect Agent Cancer. 2013 Jan 16;8(1):3.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1750-9378-8-3

AUTORES / AUTHORS:  - Chang JT; Shebl FM; Pfeiffer RM; Biryahwaho B; Graubard BI; Mbulaiteye SM

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: Kaposi sarcoma-associated herpesvirus (KSHV) seropositivity is associated with sexual, environmental, and socioeconomic exposures. Whether these characteristics are independent risk factors is uncertain because of reliance on selected high-risk or hospital-based populations and incomplete adjustment for confounding. Therefore, we evaluated risk factors for KSHV seropositivity in a population-based study in Uganda using principal components analysis (PCA). METHODS: The study population comprised 2,681 individuals randomly selected from a nationally-representative population-based HIV/AIDS sero-behavioral survey conducted in 2004/05. Questionnaire and laboratory data (97 variables) were transformed into a smaller set of uncorrelated variables using PCA. Multivariable logistic regression models were fitted to estimate odds  ratios and 95% confidence intervals for the association between components and KSHV seropositivity. RESULTS: Data were reduced to three principal components (PCs) labeled as sexual-behavioral, socioeconomic, and knowledge PCs. In crude analysis, KSHV seropositivity was associated with the Knowledge (ptrend = 0.012)  and Socioeconomic components (ptrend = 0.0001), but not with the Sexual-behavioral component (ptrend = 0.066). KSHV seropositivity was associated  with the Socioeconomic PC (ptrend = 0.037), but not with the Sexual-behavioral and Knowledge PCs, in the models including PCs, age, gender and geographic region. CONCLUSIONS: Our results fit with the view that in Uganda socioeconomic characteristic may influence KSHV seropositivity. Conversely, the results fit with the interpretation that in Uganda sexual-behavioral characteristics, if relevant, contribute minimally.

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[604]

TÍTULO / TITLE:  - Off-clamp laparoscopic partial nephrectomy for a fat-poor angiomyolipoma arising  from the renal capsule: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Urol. 2012;2012:484790. doi: 10.1155/2012/484790. Epub 2012 Nov 20.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/484790

AUTORES / AUTHORS:  - Kodama K; Takase Y; Motoi I; Saito K

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Toyama City Hospital, Toyama 939-8511, Japan.

RESUMEN / SUMMARY:  - Renal function can be significantly preserved after nephron-sparing surgery by decreasing the intraoperative ischemic duration or by performing off-clamp surgery. We report the case of a 56-year-old woman diagnosed with a minimal-fat angiomyolipoma arising from the renal capsule, which was successfully treated by  retroperitoneoscopic partial nephrectomy without hilar clamping. Computed tomography revealed a 16 x 13 mm homogenous lenticular mass protruding from the lateral aspect of the left kidney. On both T1- and T2-weighted magnetic resonance images, the mass exhibited homogenous low-signal intensity and well-defined margins. Laparoscopic magnification indicated that the exophytic tumor was attached to the renal cortex by a small peduncle. The tumor was resected completely with negative surgical margin. The estimated glomerular filtration rate after surgery was nearly equal to that before surgery. Off-clamp laparoscopic partial nephrectomy is a feasible surgical option to prevent ischemic renal damage in select patients presenting with small, exophytic, and peripheral renal masses.

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[605]

TÍTULO / TITLE:  - Sarcomatoid variant of urothelial carcinoma: Cytological analysis of three cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Jan;5(1):49-52. Epub 2012 Oct 24.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.990

AUTORES / AUTHORS:  - Arita N; Ishida M; Yoshida K; Kagotani A; Iwamoto N; Iwai M; Okabe H

INSTITUCIÓN / INSTITUTION:  - Division of Diagnostic Pathology and Department of Clinical Laboratory Medicine,  Shiga University of Medical Science, Shiga 520-2192, Japan.

RESUMEN / SUMMARY:  - Sarcomatoid variant of urothelial carcinoma (SV-UC) is characterized by the presence of biphasic malignant neoplastic components exhibiting morphological and/or immunohistochemical evidence of epithelial and mesenchymal differentiation. SV-UC is a rare variant of UC and the cytological features of this tumor have not been well described. In the present study, we analyzed the cytological features of a series of SV-UC cases; 6 voided urine specimens from 3  patients with SV-UC were reviewed. Several characteristic cytological features were revealed: i) tumor cells were abundant in a necrotic background and while single tumor cells were predominant, small clusters of cells were occasionally present; ii) tumor cells were large-sized and round to polygonal in shape with ill-defined cell borders; iii) tumor cells had a high nuclear/cytoplasmic ratio and enlarged round to oval nuclei containing coarse chromatin and occasional nucleoli; and iv) spindle-shaped atypical cells were rarely identified (1/6 specimens). The cytological features of i), ii) and iii) are indistinguishable from those of conventional invasive high-grade UC. We hypothesize that these tumor cells originated from the conventional high-grade UC component of SV-UC as  this component is usually present in this type of lesion, particularly on the surface of the tumor. Moreover, the sarcomatoid component of SV-UC is usually present in the deeper portion of the tumor and therefore detection of this component in the voided cytological specimen is low. Although cytodiagnosis of SV-UC is extremely difficult, cytodiagnosis of malignancy may prove possible due  to the presence of a conventional UC component.

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[606]

TÍTULO / TITLE:  - Monostotic fibrous dysplasia of the rib: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Orthop. 2012;2012:690914. doi: 10.1155/2012/690914. Epub 2012 Dec 10.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/690914

AUTORES / AUTHORS:  - Mahadevappa A; Patel S; Ravishankar S; Manjunath GV

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, JSS Medical College, JSS University, No. 1036, 5th Main  10th Cross, 1st Stage Vijayanagar, Karnataka, Mysore 570017, India.

RESUMEN / SUMMARY:  - Fibrous dysplasia is a noninherited bone disease in which abnormal differentiation of osteoblasts leads to replacement of normal marrow and cancellous bone by immature bone with fibrous stroma. Monostotic fibrous dysplasia accounts for 28% in the ribs. It is often asymptomatic and incidentally detected on radiographs. As with many bone abnormalities, it can be superimposed  by the formation of aneurysmal bone cysts. We report a case of a 70-year-old lady who presented with swelling on the chest wall of 20-ear duration and sudden increase in size for 8 months. Radiologically, X-ray and CT scan showed an expansible lesion of the medullary cavity with a ground-glass centre and thinning of cortex of the 5th rib. The resected lesion was a firm, well-defined solid, grey-white expansile mass replacing the medullary cavity. Histopathologically, benign fibrous spindle areas with disorganized irregular bony trabeculae were seen. Hemorrhagic spaces lined by osteoclast-like multinucleated giant cells were also noted. The diagnosis was fibrous dysplasia with aneurysmal bone cyst changes. Although fibrous dysplasia with aneurysmal bone cyst is rare, it should  be taken into account in differential diagnosis of the rapidly growing solitary rib lesion.

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[607]

TÍTULO / TITLE:  - Intraosseous neurofibroma and concurrent involvement of the mandible, maxilla and orbit: report of a case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Iran J Radiol. 2012 Mar;9(1):45-9. doi: 10.5812/iranjradiol.6684. Epub 2012 Mar 25.

            ●● Enlace al texto completo (gratuito o de pago) 5812/iranjradiol.6684

AUTORES / AUTHORS:  - Dalili Z; Adham G

INSTITUCIÓN / INSTITUTION:  - Department of Maxillofacial Radiology, Dental School, Guilan University of Medical Sciences, Rasht, Iran.

RESUMEN / SUMMARY:  - Neurofibroma is an autosomal dominant disorder which has major criteria such as hyperpigmentation (cafe-au lait spots), cutaneous and subcutaneous tumors and bone deformities. In this report, a case of multifocal intraosseous neurofibroma  in a 16-year-old male with right facial asymmetry, multiple unerupted maxillary posterior teeth and a previous history of infratemporal and orbital neurofibroma  is presented. The majority of reported cases occurred in the posterior portion of the mandible and a limited number in the maxilla. Cone beam CT (CBCT) was performed for better evaluation of the extension and form of the maxillary and mandibular lesions. This report presents a rare situation of simultaneous peripheral neurofibromatosis (NF) and multifocal intraosseous NF in the mandible, maxilla and orbits and also focuses on advanced imaging findings of bony and soft tissue neurofibroma.

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[608]

TÍTULO / TITLE:  - Pedunculated cecal lipoma causing colo-colonic intussusception: a rare case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Surg. 2012;2012:279213. doi: 10.1155/2012/279213. Epub 2012 Dec 5.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/279213

AUTORES / AUTHORS:  - Atmatzidis S; Chatzimavroudis G; Patsas A; Papaziogas B; Kapoulas S; Kalaitzis S; Ananiadis A; Makris J; Atmatzidis K

INSTITUCIÓN / INSTITUTION:  - 2nd Surgical Department, School of Medicine, Aristotle University of Thessaloniki, G. Gennimatas General Hospital, Ethnikis Aminis 41, 54635 Thessaloniki, Greece.

RESUMEN / SUMMARY:  - Colonic lipomas are uncommon nonepithelial neoplasms that are typically sessile,  asymptomatic and incidentally found during endoscopy, surgery, or autopsy. We present a very rare case of a 34-year-old female patient with symptomatic pedunculated cecal lipoma causing intermittent colo-colonic intussusception. Despite adequate imaging studies, definite preoperative diagnosis was not established and the patient underwent exploratory laparotomy. Intraoperatively, intussusception of the cecum into the ascending colon was found and right hemicolectomy was performed. Macroscopic assessment of the resected specimen showed the presence of a giant cecal pedunculated polypoid tumor with features of lipoma, causing intussusception. Histopathological examination confirmed the diagnosis of pedunculated cecal lipoma.

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[609]

TÍTULO / TITLE:  - Fibrolipoma with Osseous and Cartilaginous Metaplasia of Hoffa’s Fat Pad: A Case  Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Orthop. 2012;2012:547963. doi: 10.1155/2012/547963. Epub 2012 Aug 2.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/547963

AUTORES / AUTHORS:  - Gigis I; Gigis P

INSTITUCIÓN / INSTITUTION:  - Orthopaedics, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece ;  Orthopaedic Department, Interbalkan Medical Center, Asklipiou 10, Pylaia, 57001 Thessaloniki, Greece.

RESUMEN / SUMMARY:  - The most common benign tumors of the mesenchyme are the lipomas. Benign fatty tumors can arise in any location in which fat is present. Fibrolipomas are characterised by fat modules. Most patients affected by such tumors are in the fifth or sixth decade of life. When very close to vital structures such as joints, they may cause functional limitations as well as pain. Osseous and chondroid metaplasia can infrequently manifest after chronic persistence. Given the rarity of this condition, a case of a big fibrolipoma of Hoffa’s fat pad with osseous and cartilaginous metaplasia is reported. A 44-year-old woman presented with an enlarging soft mass on the right knee in the infrapatellar fat pad. After a thorough preoperative clinical and imaging examination, the mass was removed and sent to laboratory where the diagnosis was put. One year after surgery, both  local and general condition of the patient were good and no signs of recurrence were found.

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[610]

TÍTULO / TITLE:  - Primary Pleomorphic Undifferentiated Sarcoma-a Rare Renal Localization: A Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Urol. 2012;2012:862493. doi: 10.1155/2012/862493. Epub 2012 Nov 19.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/862493

AUTORES / AUTHORS:  - Mellas S; Bouchikhi AA; Tazi MF; Khallouk A; Elammari JE; El Fassi MJ; Mellas N; Farih MH

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Hassan II University Hospital of Fez, Fez 30020, Morocco ; Department of Anatomy, Faculty of Medicine of Fez, Fez, Morocco.

RESUMEN / SUMMARY:  - Undifferentiated pleomorphic sarcoma is known as a soft tissue sarcoma. Very few  cases of this tumor originating from the renal parenchyma or renal capsule have been reported. We report a case of a 70-year-old patient admitted for enormous ureterohydronephrosis and pyelonephritis due to a pelvic ureter lithiasis. After  draining by ureteral double J catheter, a nephroureterectomy was performed for nonfunctional kidney confirmed by scintigraphy. The histopathological study shows a pleomorphic undifferentiated sarcoma. The patient was sent to oncologists. Chemotherapy was proposed but the family decided to stop the treatment. The patient passed away 10 months later. Clinicians and pathologists should be aware  of the very low occurrence of this renal tumor, which is extremely rare. Currently there is no consensus about its management. Our case extends the literature concerning this tumor.

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[611]

TÍTULO / TITLE:  - Atrophic dermatofibrosarcoma protuberans: report of a case demonstrated by detecting COL1A1-PDGFB rearrangement.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2012 Nov 30;7:166. doi: 10.1186/1746-1596-7-166.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-7-166

AUTORES / AUTHORS:  - Qiao J; Patel KU; Lopez-Terrada D; Fang H

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No, 79, Qingchun Road, Hangzhou, 310003, People’s Republic of China. fanghongzy@sina.com.

RESUMEN / SUMMARY:  - ABSTRACT: Dermatofibrosarcoma protuberans is a locally aggressive mesenchymal neoplasm. It usually presents as an indurated plaque that protrudes above the surface of the skin. Some patients have clinically persistent plaques that might  be atrophic. The atrophic variant of dermatofibrosarcoma protuberans may be confused with some common skin diseases with atrophic appearance. We reported a 40-year-old woman who had a 10-year history of an atrophic dermatofibrosarcoma protuberans. Molecular analysis showed a fusion between COL1A1 exon 31 to exon 2  of PDGFB. The lesion was totally excised, with negative margins of the resection  demonstrated by CD34 immunostaining. To our knowledge, this is the second case of atrophic dermatofibrosarcoma protuberans confirmed by detection of COL1A1-PDGFB fusion gene. This appears to be the first report of a fusion between COL1A1 exon  31 to exon 2 of PDGFB in atrophic dermatofibrosarcoma protuberans. VIRTUAL SLIDES: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1249657688795311.

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[612]

TÍTULO / TITLE:  - Bone metastases from gastrointestinal stromal tumor: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol Med. 2012;2012:509845. doi: 10.1155/2012/509845. Epub 2012 Dec 3.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/509845

AUTORES / AUTHORS:  - Feki J; Bouzguenda R; Ayedi L; Bradi M; Boudawara T; Daoud J; Frikha M

INSTITUCIÓN / INSTITUTION:  - Oncology Department, Habib Bourguiba University Hospital, El Ain Road, 3029 Sfax, Tunisia.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Their most common metastatic sites are the liver and the peritoneum, but GISTs rarely metastasize to the bones. We report a case of a 58-year-old man with sternoclavicular joint metastasis from a GIST manifesting 28 months after surgical resection of the small intestine tumor. We will discuss through this paper and a literature review the clinical characteristics, imaging features, and management of this unusual metastatic location of GIST.

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[613]

TÍTULO / TITLE:  - Osteosarcoma of the mandible masquerading as a dental abscess: report of a case.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Dent. 2012;2012:635062. doi: 10.1155/2012/635062. Epub 2012 Nov 29.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/635062

AUTORES / AUTHORS:  - Anil S; Krishnan AP; Rajendran R

INSTITUCIÓN / INSTITUTION:  - Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 60169, Riyadh 11545, Saudi Arabia.

RESUMEN / SUMMARY:  - An aggressive and fatal case of osteosarcoma of the mandible in a 19-year-old female is reported. Six weeks after the clinical appearance of the swelling, the  patient died. This paper is unique in that the age of occurrence and the biologic behavior of the tumor were not consistent with the reported literature. The case  report is followed by a brief review of osteosarcoma of the jaw with a note on its clinical presentation, diverse radiologic appearance, varied histopathologic  picture, and prognosis.

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[614]

TÍTULO / TITLE:  - A case report of spindle cell (sarcomatoid) carcinoma of the larynx.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Report Med. 2012;2012:370204. doi: 10.1155/2012/370204. Epub 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/370204

AUTORES / AUTHORS:  - Boamah H; Ballard B

INSTITUCIÓN / INSTITUTION:  - Meharry Medical College, 1005 DR DB Todd Boulevard, Nashville, TN 37208, USA.

RESUMEN / SUMMARY:  - Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous  appearance. Most spindle cell tumors are polypoid and pedunculated; they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his  voice, dysphagia, odynophagia and a 20-pound weight loss. The patient underwent direct laryngoscopy with excision of the malignant mass and received radiation therapy. His symptoms gradually improved, and he regained good control of his voice.

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[615]

TÍTULO / TITLE:  - Fine needle aspiration cytology of pseudosarcomatous reactive lesions of soft tissues: A report of two cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cytol. 2012 Oct;29(4):264-6. doi: 10.4103/0970-9371.103949.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0970-9371.103949

AUTORES / AUTHORS:  - Satish S; Shivalingaiah SC; Ravishankar S; Vimalambika MG

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, JSS Medical College, JSS University, Mysore, Karnataka,  India.

RESUMEN / SUMMARY:  - Pseudosarcomatous lesions are reactive proliferative lesions of the soft tissue,  that are likely to be misdiagnosed as malignant, based on clinical and histological features. The most common lesions are nodular fasciitis, proliferative fasciitis, proliferative myositis and myositis ossificans. These rapidly growing soft-tissue lesions can represent a variety of diagnoses involving radically different treatment modalities. Accurate diagnosis is important to avoid unnecessary and often mutilating surgery. We report two cases  to illustrate the importance of correct identification of these lesions by fine needle aspiration cytology.

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[616]

TÍTULO / TITLE:  - Primary Ewing’s Sarcoma of Penis - A Rare Case Report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):332-3. doi: 10.1007/s13193-011-0112-4. Epub 2012 Feb 29.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-011-0112-4

AUTORES / AUTHORS:  - Sharma P; Bakshi H; Chheda Y; Beniwal S

INSTITUCIÓN / INSTITUTION:  - Department of Uro-oncology, The Gujarat Cancer and Research Institute, Asarva, Ahmedabad, Gujarat India ; 82/142, Neelgiri Marg, Mansarovar, Jaipur, Pin - 302020 Rajasthan India.

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[617]

TÍTULO / TITLE:  - Giant primary ovarian fibrosarcoma: Case report and review of pitfalls.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cytol. 2012 Oct;29(4):255-7. doi: 10.4103/0970-9371.103946.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0970-9371.103946

AUTORES / AUTHORS:  - Ray S; Biswas BK; Mukhopadhyay S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Medical College, Kolkata, India.

RESUMEN / SUMMARY:  - Primary ovarian fibrosarcomas are very uncommon neoplasms; less than one hundred  cases have been reported. Diagnosis can be difficult to establish and other similar appearing mesenchymal lesions must be ruled out. A 23 year old nulliparous woman presented with a huge right ovarian tumor (25 x 17 x 12 cm). Ultrasonography guided aspiration was performed and a strong possibility of fibrosarcoma was suggested based on cytomorphological findings. No epithelial element was noted. She underwent surgical excision which confirmed the diagnosis  of primary ovarian fibrosarcoma (the largest till date to our knowledge). Immunohistochemical analyses showed vimentin and CD 34 positivity. We speculate that ovarian fibrosarcoma at the preoperative examination might be considered in  the differential diagnosis whenever a unilateral, heterogeneous, largely round solid ovarian lesion is detected.

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[618]

TÍTULO / TITLE:  - Prostatic leiomyoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Urol. 2012;2012:702762. doi: 10.1155/2012/702762. Epub 2012 Nov 11.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/702762

AUTORES / AUTHORS:  - Mellas S; Bouchikhi AA; Tazi MF; Khallouk A; Elammari JE; El Fassi MJ; Farih MH

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Hassan II University Hospital of Fez, Fez 30020, Morocco ; Department of Anatomy, Faculty of Medicine of Fez, Fez 30020, Morocco.

RESUMEN / SUMMARY:  - Prostatic enlargement due to benign adenomatous hyperplasia is very common in elderly males. However, benign mesenchymal tumors especially true leiomyoma of the prostate are rare. We describe a 68-year-old male presenting a urinary obstruction lasting more than two years. The patient was referred for an acute urinary retention. The clinical examination was normal. The perrectal examination revealed an enlarged prostate without abnormalities. An endoscopic resection was  performed. The histopathological examination revealed a benign smooth muscle tumor with absence of glandular hyperplasia; the result was confirmed by immunohistochemistry. Accordingly, the diagnosis of true leiomyoma of the prostate was made.

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[619]

TÍTULO / TITLE:  - A case of endometrial stromal sarcoma with synchronous bilateral adenocarcinoma of ovary.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Obstet Gynecol. 2012;2012:687510. doi: 10.1155/2012/687510. Epub 2012 Nov 6.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/687510

AUTORES / AUTHORS:  - Caramelo O; Marinho C; Rebelo T; Amaral N; Mota F; Xavier da Cunha F; Torgal I

INSTITUCIÓN / INSTITUTION:  - Gynecology and Obstetrics Department, Coimbra Hospital and University Center, Praceta Professor Mota Pinto, 3000-075 Coimbra, Portugal.

RESUMEN / SUMMARY:  - Endometrial stromal tumor is a rare mesenchymal uterine tumor. We report the case of a patient with endometrial stromal sarcoma and concomitant bilateral endometrioid adenocarcinoma of the ovary in the context of pelvic endometriosis.  The patient underwent a complete cytoreduction including total hysterectomy and bilateral adnexectomy, pelvic lymphadenectomy, appendicectomy, infracolic omentectomy, and pelvic peritonectomy. This is the first report to our knowledge  that describes a synchronous endometrial stromal sarcoma and bilateral endometrioid adenocarcinoma of the ovary.

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[620]

TÍTULO / TITLE:  - Carcinosarcoma of upper aerodigestive tract: a case series.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):316-9. doi: 10.1007/s13193-011-0110-6. Epub 2011 Dec 10.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-011-0110-6

AUTORES / AUTHORS:  - Kumar T; Kothari K; Patel MH; Kumar P; Ravi K; Yadav V

INSTITUCIÓN / INSTITUTION:  - Surgical Oncology, Gujarat Cancer Research Institute, Ahmedabad, India ; Department of Surgical Oncology, Gujarat Cancer and Research Institute, New Civil Hospital Campus, Asarva, Ahmedabad, 380016 India.

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[621]

TÍTULO / TITLE:  - Extraskeletal osteosarcoma of penis: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chin J Cancer Res. 2012 Jun;24(2):164-6. doi: 10.1007/s11670-012-0164-1.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11670-012-0164-1

AUTORES / AUTHORS:  - Wu CZ; Li CM; Han S; Wu S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, the 208th Hospital of PLA, Changchun 130062, China.

RESUMEN / SUMMARY:  - Extraskeletal osteosarcoma (EOS) is rare and commonly arises in the retroperitoneum, limbs, head and neck. There is no significant difference between EOS and other malignant tumors in soft tissue. Localized pain and swelling are the common presenting symptoms. Clinical diagnosis of EOS is difficult, imaging techniques may be helpful and careful, and the histopathological analysis is necessary. The common histological variants of EOS include: osteoblastoma, chondroblastoma, and fibroblastoma, and other unusual subtypes were reported occasionally. It should be distinguished with myositis ossificans, malignant mesenchymoma, giant cell tumor and parosteal osteosarcoma. We present an EOS arising in the penis. The primary site and histological category of the tumor were extremely rare. We hope the case will be helpful to the recognition of clinical signs, iconography and histopathology of EOS.

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[622]

TÍTULO / TITLE:  - A rare case of primary fibrosarcoma of kidney.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Iran J Kidney Dis. 2013 Jan;7(1):67-9.

AUTORES / AUTHORS:  - Chaudhari S; Hatwal D; Suri V

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Veer Chandra Singh Garhwali Government Medical Sciences  and Research Institute, Srinagar, Pauri Garhwal Uttarakhand, India. drcnsuk@yahoo.com.

RESUMEN / SUMMARY:  - Primary sarcomas of kidney are rare tumors accounting for 1% to 3% of all primary renal malignancies. Among sarcomas fibrosarcoma is rare. Here we report a case of primary fibrosarcoma of the kidney in a 70-year-old man who presented with gradually increasing abdominal swelling and pain.

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[623]

TÍTULO / TITLE:  - Giant retroperitoneal liposarcoma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol Med. 2012;2012:869409. doi: 10.1155/2012/869409. Epub 2012 Nov 26.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/869409

AUTORES / AUTHORS:  - Shahaji C; Amit P; Prashant P; Sachin T

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Padmashree Dr. D. Y. Patil Medical College Hospital & Research Centre, Pimpri, Pune 411018, India.

RESUMEN / SUMMARY:  - Soft tissue sarcomas represent less than 1% of all human neoplasms. One-third of  malignant tumors that arise in the retroperitoneum are sarcomas and liposarcoma is the most common retroperitoneal sarcoma. More often than not, patients report  late to the hospital due to the slow progress and few late symptoms. Thus, the tumor is known to grow to enormous sizes. Here, we report a case of giant retroperitoneal liposarcoma weighing more than 7 kgs.

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[624]

TÍTULO / TITLE:  - Intracranial cystic chondroma: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Case Rep. 2012 Dec 28;6(1):432. doi: 10.1186/1752-1947-6-432.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1752-1947-6-432

AUTORES / AUTHORS:  - Uddin MM; Ashraf J; Memon AA; Ali J

INSTITUCIÓN / INSTITUTION:  - Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan. akhtar.amin@live.com.

RESUMEN / SUMMARY:  - ABSTRACT: INTRODUCTION: Intracranial chondromas are rare benign tumors with an incidence of 0.2% to 0.3% of all intracranial tumors. This is the first case of an intracranial chondroma reported from Pakistan. CASE PRESENTATION: We report a  case of a 23-year-old Asian man presenting with intracerebral chondroma of the left frontal lobe, which was eroding the dura matter. The intracranial chondroma  was completely removed by surgery. CONCLUSION: Intracranial chondromas are rare benign cartilaginous tumors. Through this case presentation we have discussed the diagnostic procedures, radiological and pathological findings. The purpose of presenting such a rare case is to develop awareness among clinicians and medical  students and to highlight the requirement of immediate actions to ensure proper management of such cases.

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[625]

TÍTULO / TITLE:  - Clear cell sarcoma of the jejunum: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Surg Oncol. 2013 Jan 25;11(1):17.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1477-7819-11-17

AUTORES / AUTHORS:  - Lasithiotakis K; Protonotarios A; Lazarou V; Tzardi M; Chalkiadakis G

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: Clear cell sarcoma (CCS), also known as malignant melanoma  of soft parts, is a rare type of soft tissue sarcoma which exhibits morphological, immunohistochemical and ultrastructural similarity with malignant  melanoma. It is rarely localized in the intestine and the natural history of this tumor is not yet clear.Case report: A 49-year-old woman presented with diffuse abdominal colicky pain and vomitus over the previous seven days. An X-ray of the  abdomen revealed obstruction of the small intestine. The patient underwent contrast enhanced abdominal computerized tomography (CT), which confirmed the obstruction at the jejunum and an associated circumferential wall thickening extending about 3 cm in length, causing concentric narrowing of the lumen. At laparotomy, a mass was recognized at the level of the jejunum in the small intestine, which caused almost complete obstruction of the lumen. At the point of obstruction, adhered loops of small intestine were found. A segmental small bowel resection was performed with 5 cm clear margins and its respective mesenteric lymph nodes. RESULTS: Histological examination of the specimen revealed a tumor (3 x 3 x 2 cm) with epithelioid cell characteristics and eosinophilic or clear cytoplasm and focal translucent nuclei. Immunohistochemistry was positive for S100, epithelial membrane antigen (EMA) and synaptophysin. The tumor was pankeratin AE1/AE2, GFAP, HMB45 and MART-1/Melan-A negative. Twelve lymph nodes were retrieved and were free of neoplastic infiltration. Cytogenetic examination  revealed translocation of the EWSR1 gene. The patient had an uncomplicated postoperative course and left the hospital seven days after her admission in good general condition. After 20 months of follow-up the patient remains asymptomatic  without any clinical or radiological evidence of recurrence. CONCLUSION: CCS sarcoma can be rarely localized in the jejunum. Due to its morphological similarity to malignant melanoma, cytogenetic examination is necessary for its diagnosis. Wide resection of the tumor and its respective lymph nodes was associated with a 20-month disease free survival in this patient.

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[626]

TÍTULO / TITLE:  - Rhabdomyosarcoma in a terrestrial tortoise (Geochelone nigra) in Nigeria: A case  report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J S Afr Vet Assoc. 2012 Nov 30;83(1):E1-5. doi: 10.4102/jsava.v83i1.300.

AUTORES / AUTHORS:  - Eyarefe OD; Antia RE; Oguntoye CO; Abiola OO; Alaka OO; Ogunsola JO

INSTITUCIÓN / INSTITUTION:  - Department of Veterinary Surgery and Reproduction, University of Ibadan. wumcel06@yahoo.com.

RESUMEN / SUMMARY:  - A skeletal muscle tumour (rhabdomysarcoma) was diagnosed in a 4-year-old captive  female terrestrial tortoise (Geochelone nigra) weighing 7 kg presented at the Veterinary Teaching Hospital, University of Ibadan, Ibadan, Nigeria. The tumour was located at the anterior right portion of the body and ventral to the carapace. The location of the tumour prevented the tortoise from extending its head from the body. The tumour was a sessile, smooth white mass, with a soft myxomatous consistency. The histological features that were diagnostic of rhabdomyosarcoma included a sparse population of haphazardly arranged spindle-shaped cells within a homogenous matrix (anisocytosis), occasional tumour giant and binucleate cells, and some well differentiated myofibrils with cross striations within the cytoplasm. The paucity of information on tumours in the land tortoise was the reason for this report, which appears to be the first report of rhabdomyosarcoma in the tortoise.

 

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[627]

TÍTULO / TITLE:  - A case of chondrosarcoma that primarily developed in the cervical spine.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Iran J Radiol. 2012 Mar;9(1):57-9. doi: 10.5812/iranjradiol.6344. Epub 2012 Mar 25.

            ●● Enlace al texto completo (gratuito o de pago) 5812/iranjradiol.6344

AUTORES / AUTHORS:  - Hekmatnia A; Ghazavi A; Aminmansour B; Mahzouni P

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Image Processing and Signal Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

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[628]

TÍTULO / TITLE:  - Low-grade fibromyxoid sarcoma of the vulva: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Low Genit Tract Dis. 2013 Jan;17(1):79-81. doi: 10.1097/LGT.0b013e318256da58.

            ●● Enlace al texto completo (gratuito o de pago) 1097/LGT.0b013e318256da58

AUTORES / AUTHORS:  - VanSandt AM; Bronson J; Leclair C; Mansoor A; Goetsch M

INSTITUCIÓN / INSTITUTION:  - Departments of Pathology, Oregon Health and Science University, Portland, OR 97239, USA. vansanda@ohsu.edu

RESUMEN / SUMMARY:  - OBJECTIVE: The study aimed to describe a case of low-grade fibromyxoid sarcoma arising from the vulva and to discuss the diagnostic challenges, clinical management, and epidemiology of this rare malignancy. CASE: A 36-year-old woman presented to 3 separate emergency departments with complaints of a painful and slowly enlarging vulvar mass. Eventual gynecologic referral resulted in excision  of a 6-cm, noncystic vulvar mass. Pathological diagnosis revealed low-grade fibromyxoid sarcoma. Later, a right radical hemivulvectomy ensured adequate margins, and 2 years later, the patient is free of recurrent and metastatic disease. CONCLUSIONS: Low-grade fibromyxoid sarcoma is a rare malignancy that may present in the lower genital tract. Definitive diagnosis is essential because low-grade fibromyxoid sarcoma may metastasize many years after diagnosis, thereby requiring indefinite clinical surveillance.

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[629]

TÍTULO / TITLE:  - Arthroscopic excision of intra-articular hip osteoid osteoma: a report of 2 cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Orthop. 2012;2012:820501. doi: 10.1155/2012/820501. Epub 2012 Dec 11.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/820501

AUTORES / AUTHORS:  - Nehme AH; Bou Ghannam AG; Imad JP; Jabbour FC; Moucharafieh R; Wehbe J

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery and Traumatology, Saint Georges University Medical Center, Balamand University, P.O. Box 166378, Achrafieh, Beirut 1100 2807, Lebanon.

RESUMEN / SUMMARY:  - Intra-articular osteoid osteoma is uncommon accounting for approximately 12% of all osteoid osteomas. It presents diagnostic and therapeutic challenges since several traumatic or degenerative pathologies of the joint can be simulated with  delay in the diagnosis. We report the clinical, radiographic, and histopathological findings in 2 cases of intra-articular osteoid osteoma of the femoral neck and of the acetabulum. Technical aspects of arthroscopic excision and results of surgery are discussed. Arthroscopy allowed complete excision of the osteoid osteomas, with a short postoperative rehabilitation and excellent functional results.

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[630]

TÍTULO / TITLE:  - Spinal Neurofibroma Masquerading as a Herniated Disc: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sultan Qaboos Univ Med J. 2012 Nov;12(4):522-5. Epub 2012 Nov 20.

AUTORES / AUTHORS:  - Lamki T; Ammirati M

INSTITUCIÓN / INSTITUTION:  - Department of Neurological Surgery, Ohio State University, Columbus, Ohio, USA.

RESUMEN / SUMMARY:  - We present the only case in English medical literature of a spinal neurofibroma misdiagnosed as a herniated disc using magnetic resonance imaging (MRI). This case presented with typical symptoms and radiological findings of a herniated disc. Intraoperatively, an abnormality was noted at the S1 nerve root sleeve. Further exploration revealed a spinal neurofibroma which was completely resected, resulting in an improvement in the patient’s symptoms. Currently, there is heavy  reliance on MRI as a highly sensitive and specific tool used in the diagnosis of  herniated lumbar discs. Although there have been occasional reports of misdiagnoses using MRI, there are no reported cases of a spinal neurofibroma being misdiagnosed as a herniated lumbar disc. Despite great advances in radiological diagnostic imaging, surgical surprises do still occur. Ultimately, instinct is still essential in intraoperative surgical decisions.

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[631]

TÍTULO / TITLE:  - Acute Fulminant Form of Budd-Chiari Syndrome Secondary to Inferior Vena Cava Sarcoma: a Case Report and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Cancer. 2013 Jan 3.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12029-012-9475-1

AUTORES / AUTHORS:  - Sherid M; Samo S; Suliaman S; Gaziano JH

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, Division of Gastroenterology, CGH Medical Center, 100 East LeFevre Road, Sterling, IL, 61071, USA, muhammedsherid@yahoo.com.

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[632]

TÍTULO / TITLE:  - Clival chordoma with an atypical presentation: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Case Rep. 2012 Nov 29;6(1):410. doi: 10.1186/1752-1947-6-410.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1752-1947-6-410

AUTORES / AUTHORS:  - Alshammari J; Monnier P; Daniel RT; Sandu K

INSTITUCIÓN / INSTITUTION:  - Department of Otorhinolaryngology, University Hospital - CHUV, Lausanne, Switzerland. kishore.sandu@hopitalvs.ch.

RESUMEN / SUMMARY:  - ABSTRACT: INTRODUCTION: Clival chordomas present with headache, commonly VI cranial nerve palsy or sometimes with lower cranial nerve involvement. Very rarely, they present with cerebrospinal fluid rhinorrhoea due to an underlying chordoma-induced skull base erosion. CASE PRESENTATION: A 60-year old Caucasian woman presented with meningitis secondary to cerebrospinal fluid rhinorrhoea. At  first, radiological imaging did not reveal a tumoral condition, though intraoperative exploration and tissue histology revealed a chordoma which eroded  her clivus and had a transdural extension. CONCLUSION: Patients who present with  meningitis and cerebrospinal fluid rhinorrhoea could have an underlying erosive lesion which can sometimes be missed on initial radiological examination. Surgical exploration allows collecting suspicious tissue for histological diagnosis which is important for the actual treatment. A revision endoscopic excision of a clival chordoma is challenging and has been highlighted in this report.

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[633]

TÍTULO / TITLE:  - Nonossifying fibroma presenting as an aneurysmal bone cyst: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Med Case Rep. 2012 Nov 29;6(1):407. doi: 10.1186/1752-1947-6-407.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1752-1947-6-407

AUTORES / AUTHORS:  - Sakamoto A; Ishii T; Oda Y; Iwamoto Y

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, National Hospital Organization Kokura Medical  Center, Kitakyushu, Fukuoka, Japan. akio@med.kyushu-u.ac.jp.

RESUMEN / SUMMARY:  - ABSTRACT: INTRODUCTION: Nonossifying fibroma is a common fibrous bone lesion in children that occurs in the metaphysis of the long bones of the lower extremities. The lesion rarely leads to aneurysmal bone cyst, which is characterized as a blood-filled space. CASE PRESENTATION: We present the case of  a 13-year-old Japanese boy with a complaint of discomfort in the thigh and a small, well-defined, osteolytic lesion with cortical thinning located in the medullary space of the distal diaphysis of the femur. At 10-month follow-up, the  size of the lesion had increased. Gadolinium-enhanced magnetic resonance imaging  failed to detect any solid area. Curettage and bone graft were performed and confirmed a blood-filled cystic lesion. The pathological diagnosis of the cyst wall was that of nonossifying fibroma, suggesting aneurysmal bone cyst as a secondary change. An aneurysmal bone cyst is rarely found secondary to nonossifying fibroma, and the diaphyseal location is atypical for nonossifying fibroma, both of which made diagnosis challenging. CONCLUSION: The current case is a reminder to clinicians that, although rare, nonossifying fibroma can be associated with aneurysmal bone cyst, and both can occur in the diaphysis of long bones.

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[634]

TÍTULO / TITLE:  - Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Jan;5(1):97-100. Epub 2012 Oct 1.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.948

AUTORES / AUTHORS:  - Zhao HD; Wu T; Wang JQ; Zhang WD; He XL; Bao GQ; Li Y; Gong L; Wang Q

INSTITUCIÓN / INSTITUTION:  - Departments of General Surgery.

RESUMEN / SUMMARY:  - Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. In the present study, we present a case of IMT in a 56-year-old female patient who was admitted to our  hospital due to a mass found in her right breast. Mammogram and ultrasound revealed a well-circumscribed mass and surgery was performed. Histopathologically, the lesion was composed of spindle and inflammatory cells, including plasma cells and lymphocytes. Mitotic figures were not observed. Immunohistochemically, the tumor cells were positive for SM-actin, anaplastic lymphoma kinase (ALK) and vimentin and focal positive for desmin, but negative for NSE, S-100, CD117, CD34, NF, CD21, CD35 and CD68. Thus, we made a diagnosis of IMT and advised regular follow-up. However, the patient had local recurrence and metastasis to the left groin area 3, 7 and 10 months after the initial surgery. Notably, the histopathological characteristics of the recurrent and metastatic foci were similar to those of the initial specimen, but mitotic figures were clearly observed. Thus, we conclude that IMT shows occasionally malignant biological behavior although it is a neoplasm of intermediate biological potential that frequently recurs and rarely metastasizes. We advise that clinical physicians should regularly follow up patients after focal resection for IMT.

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[635]

TÍTULO / TITLE:  - Pseudosarcomatous myofibroblastic tumour of the urinary bladder: a case report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Diagn Res. 2012 Oct;6(8):1422-4. doi: 10.7860/JCDR/2012/4187.2376.

            ●● Enlace al texto completo (gratuito o de pago) 7860/JCDR/2012/4187.2376

AUTORES / AUTHORS:  - Chandramouleeswari K; Anita S; Shivali B

INSTITUCIÓN / INSTITUTION:  - Associate Professor of Pathology, Chengelpet Medical college . Consultant pathologist, Lister Metropolis, Chennai, India.

RESUMEN / SUMMARY:  - A pseudosarcomatous myofibroblastic proliferation is an unusual and a rare benign lesion which arises from the bladder submucosal stroma and is easily mistaken for a malignant neoplasm, clinically, radiologically and histologically. By definition, the tumour is composed of a dominant spindle cell proliferation with  a variable inflammatory component. These spindle cells are now known to be myofibroblasts and this is the reason for the current designation for this disease. The term ‘inflammatory’ may not be applicable to all the tumours, since  some investigators have demonstrated the presence of chromosomal abnormalities and have documented cases which showed recurrence, thus supporting the theory that at least some of these tumours were true neoplasms.Non-epithelial tumours account for 2-5% of all the primary urinary bladder neoplasms, with the most common types being rhabdomyosarcoma in patients under the age of 10 years and leiomyosarcoma in adults. A pseudosarcomatous myofibroblastic tumour is a nonepithelial lesion that follows a benign indolent course and a conservative management has been reported as the treatment of choice. Herein, we are reporting a case of a pseudosarcomatous myofibroblastic tumour which was mistaken for a sarcoma clinically and radiologically and which was proved as a pseudosarcomatous inflammatory myofibroblastic tumour by histopathology and immunohistochemistry.

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[636]

TÍTULO / TITLE:  - Primary cardiac angiosarcoma: A diagnostic challenge in a young man with recurrent pericardial effusions.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Clin Cardiol. 2012 Winter;17(1):39-42.

AUTORES / AUTHORS:  - Riles E; Gupta S; Wang DD; Tobin K

INSTITUCIÓN / INSTITUTION:  - Division of Cardiovascular Medicine, University of Michigan Health Systems, Cardiovascular Center, Ann Arbor, Michigan, USA.

RESUMEN / SUMMARY:  - Cardiac angiosarcomas are rare, rapidly progressive tumours that often present as diagnostic dilemmas resulting in delayed diagnosis. They should be considered in  patients with recurrent pericardial effusions.A 33-year-old man presented for evaluation of a recurrent pericardial effusion. Infectious and rheumatological workups were negative. Pericardial fluid cytology and pericardial biopsy were unremarkable. Imaging, including echocardiogram and magnetic resonance imaging, were nondiagnostic.While awaiting surgical intervention, the patient developed respiratory failure requiring urgent intubation. Intraoperatively, he experienced significant hemorrhage from the myocardium. Hemostasis could not be achieved and  the patient expired. Pathology reports revealed metastatic angiosarcoma.The present case illustrates a rare case of primary cardiac angiosarcoma posing a diagnostic dilemma in a young man. The authors present the challenges in diagnosis, and review the most current diagnostic and therapeutic strategies in the care of patients with this condition.

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[637]

TÍTULO / TITLE:  - MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Orphanet J Rare Dis. 2013 Jan 11;8(1):7.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1750-1172-8-7

AUTORES / AUTHORS:  - Sarver AL; Thayanithy V; Scott MC; Cleton-Jansen AM; Hogendoorn PC; Modiano JF; Subramanian S

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: Deregulation of microRNA (miRNA) transcript levels has been observed in many types of tumors including osteosarcoma. Molecular pathways regulated by differentially expressed miRNAs may contribute to the heterogeneous  tumor behaviors observed in naturally occurring cancers. Thus, tumor-associated miRNA expression may provide informative biomarkers for disease outcome and metastatic potential in osteosarcoma patients. We showed previously that clusters of miRNAs at the 14q32 locus are downregulated in human osteosarcoma. METHODS: Human and canine osteosarcoma patient’s samples with clinical follow-up data were used in this study. We used bioinformatics and comparative genomics approaches to identify miRNA based prognostic biomarkers in osteosarcoma. Kaplan-Meier survival curves and Whitney Mann U tests were conducted for validating the statistical significance. RESULTS: Here we show that an inverse correlation exists between aggressive tumor behavior (increased metastatic potential and accelerated time to death) and the residual expression of 14q32 miRNAs (using miR-382 as a representative of 14q32 miRNAs) in a series of clinically annotated samples from  human osteosarcoma patients. We also show a comparable decrease in expression of  orthologous 14q32 miRNAs in canine osteosarcoma samples, with conservation of the inverse correlation between aggressive behavior and expression of orthologous miRNA miR-134 and miR-544. CONCLUSIONS: We conclude that downregulation of 14q32  miRNA expression is an evolutionarily conserved mechanism that contributes to the biological behavior of osteosarcoma, and that quantification of representative transcripts from this family, such as miR-382, miR-134, and miR-544, provide prognostic and predictive markers that can assist in the management of patients with this disease.

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[638]

TÍTULO / TITLE:  - Soft tissue sarcoma: new paradigms in care.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2012;2012:439208. doi: 10.1155/2012/439208. Epub 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/439208

AUTORES / AUTHORS:  - Choong P

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, University of Melbourne, St. Vincent’s Hospital Melbourne, Victoria, Australia ; Department of Orthopaedics, St. Vincent’s Hospital Melbourne, Victoria, Australia ; Bone & Soft Tissue Sarcoma Service, Peter MacCallum Cancer Centre, Victoria, Australia.

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[639]

TÍTULO / TITLE:  - Soft tissue sarcoma-review of experience at a tertiary care cancer centre.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):309-12. doi: 10.1007/s13193-011-0119-x. Epub 2012 Jan 7.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-011-0119-x

AUTORES / AUTHORS:  - Shukla NK; Deo SV

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Oncology, BRA-IRCH, All India Institute of Medical Sciences, New Delhi, 110029 India.

RESUMEN / SUMMARY:  - This study is a retrospective analysis of prospective data base of soft tissue sarcoma (STS) maintained in the department of Surgical Oncology, Bhim Rao Ambedkar Institute Rotary Cancer Hospital (BRA-IRCH), All India Institute of Medical Sciences, which is a tertiary care cancer centre. A total of 300 patients of STS were treated between 1995 and 2006. The mean age at presentation was 40.6  years and males were more affected then females. Extremity sarcomas were more common than non extremity sarcoma and lower limb dominated upper limb. The median size of tumor was 8 cm (range 1-40 cm). MRI scan was the preferred imaging modality and tissue diagnosis was obtained by core biopsy. Synovial Sarcoma and Malignant Fibrous Histiocytoma were the common histology. Majority (75%) tumors were of high grade. Patients were staged according to MSKCC staging system. Limb  Salvage Surgery was offered to all patients where ever feasible. Wide excision with a gross three dimensional tumor free margin of 2 cm was performed. Adjuvant  external beam radiotherapy was offered to all high grades, large and recurrent tumors along with perioperative brachytherapy implant for tumor bed. High grade tumors were also offered adjuvant Adriamycin based Chemotherapy. Limb salvage rate was 68% in extremity sarcoma. During follow up 114 (38%) patients had relapse of disease mainly systemic, lungs being the commonest site.

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[640]

TÍTULO / TITLE:  - Splenic hemangiosarcoma in a young sprague-dawley rat.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Toxicol Pathol. 2012 Dec;25(4):273-6. doi: 10.1293/tox.25.273. Epub 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 1293/tox.25.273

AUTORES / AUTHORS:  - Shiraki K; Ono M; Kajikawa S; Takeuchi A; Murakami Y; Oishi Y; Matsumoto M

INSTITUCIÓN / INSTITUTION:  - Drug Safety Research Laboratories, Astellas Pharma Inc., 1-6 Kashima 2-chome, Yodogawa-ku, Osaka 532-8514, Japan.

RESUMEN / SUMMARY:  - The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were  histopathologically determined to be composed of spindle- to oval-shaped cells that showed invasive growth without encapsulation and were arranged solidly but partially in whorls or faint alveolar patterns with vascular-like spaces containing small clefts or erythrocytes in the tumor mass. Immunohistochemical analysis revealed that most of the tumor cells were strongly positive for vimentin, von Willebrand factor (vWF) and CD34 but negative for podoplanin. In addition, electron microscopic examination revealed the presence of Weibel-Palade bodies in the cytoplasm of the tumor cells. Based on these findings, this case was diagnosed as a hemangiosarcoma. The splenic masses were larger than the hepatic ones, with tumor cells mainly observed at periportal regions with tumor embolism in the liver, suggesting that primary hemangiosarcoma initially developed in the spleen before metastasizing.

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[641]

TÍTULO / TITLE:  - Leiomyoma of the urinary bladder in asymptomatic women.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Urol Ann. 2012 Sep;4(3):172-4. doi: 10.4103/0974-7796.102667.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0974-7796.102667

AUTORES / AUTHORS:  - Erdem H; Yildirim U; Tekin A; Kayikci A; Uzunlar AK; Sahiner C

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Duzce University of Medical Faculty, Duzce, Turkey.

RESUMEN / SUMMARY:  - Most bladder tumors are derived from the urothelium. Benign mesenchymal tumors are rare. Leiomyomas account for less than 0.43% of all bladder tumors. Genitourinary leiomyomata may arise in any anatomic structure containing smooth muscle. They have been reported to involve single or multiple organs. Since they  may also mimic malignant lesions, they should always be considered in the differential diagnosis of any pelvic mass, with a possibility of being asymptomatic and discovered incidentally by radiographic imaging. We, herein, report a case illustrating clinical and pathological features in particular immunohistochemistry, and discuss its etiology and differential diagnosis.

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[642]

TÍTULO / TITLE:  - The significance of mean platelet volume on diagnosis and management of adenomyosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Glas Ljek komore Zenicko-doboj kantona. 2013 Feb;10(1):59-62.

AUTORES / AUTHORS:  - Bodur S; Gun I; Alpaslan Babayigit M

INSTITUCIÓN / INSTITUTION:  - 1Department of Obstetrics and Gynecology, Maresal Cakmak Millitary Hospital, Erzurum, 2Department of Obstetrics and Gynecology, GATA Haydarpasa Training Hospital, Istanbul, 3Turkish Military Health Command, Ankara; Turkey.

RESUMEN / SUMMARY:  - Aim The present study was designed to assess the signiicance of mean platelet volume on the pathogenesis and management of adenomyosis. Methods A total of 26 patients out of 123 with pathologically conirmed adenomyosis in hysterectomy specimens without concomitant gynecological pathology were selected for the study. Control group was consisted of 24 symptom-free subjects out of 35, with normal smear test and without infection. Groups were compared in terms of mean platelet volumes and platelet counts. Results The mean platelet volume values of  patients with pathologically conirmed adenomyosis were found to be signiicantly higher than the values in the control group (9.3+/-0.8 fL versus 7.3+/-0.8 fL; p  less 0.05). Platelet count comparison between the two groups showed no statistical signiicance (p>0.05). Conclusion This study conirms the previous studies indicating endometriosis and adenomyosis as inlammatory processes. As a result, mean platelet volume has shown to be a signiicant clinical marker for chronic inlammatory process of adenomyosis and endometriosis. This basic inding should be supported by new studies concerning the correlation of mean platelet volume levels with severity and duration of the disease, as well as response of mean platelet volume levels to therapies targeting chronic inlammatory process in adenomyosis and endometriosis pathogenesis.

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[643]

TÍTULO / TITLE:  - Imaging spectrum in soft tissue sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):271-9. doi: 10.1007/s13193-011-0095-1. Epub 2011 Dec 10.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-011-0095-1

AUTORES / AUTHORS:  - Aga P; Singh R; Parihar A; Parashari U

INSTITUCIÓN / INSTITUTION:  - Department of Radiodiagnosis, C.S.M. Medical University (K.G. Medical University), Type 4/87 SGPGIMS Rae Bareli Road, Lucknow, UP India.

RESUMEN / SUMMARY:  - Imaging plays an important role in detection, diagnosis as well as pre and post operative management of patients with soft tissue sarcomas. Soft tissue sarcomas  are generally a diagnostic dilemma needing the complimentary use of both radiology and pathology for their accurate diagnosis. In this review article, we  have tried to highlight the important facts about the various imaging modalities  available as well as the recent advances in the field of radiology.

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[644]

TÍTULO / TITLE:  - Solitary fibrous tumors of the soft tissues: imaging features with histopathologic correlations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Sarcoma Res. 2013 Jan 25;3(1):1.

            ●● Enlace al texto completo (gratuito o de pago) 1186/2045-3329-3-1

AUTORES / AUTHORS:  - Papathanassiou ZG; Alberghini M; Picci P; Staals E; Gambarotti M; Garaci FG; Vanel D

RESUMEN / SUMMARY:  - ABSTRACT: Purpose: To describe the imaging features of soft tissue solitary fibrous tumors, with histopathological correlations and clinical outcome. MATERIAL AND METHODS: Twenty-seven patients with histologically proven SFTs were  retrospectively evaluated. Imaging studies included six radiographs, five U/S studies, eighteen CTscans, fourteen MRI exams, and one angiography. RESULTS: On CT scans, two lesions were isodense and five were mildly hypodense compared to muscle while 11 lesions appeared heterogeneous-mixed of iso and hypodense areas.  Heterogeneous enhancement was depicted in 13 lesions and four lesions enhanced homogeneously. Six lesions were partially calcified. On T1W MR images, seven lesions were isointense and one was slightly hyperintense relative to adjacent muscles while five lesions appeared heterogeneous-mixed of iso and hypointense areas. T2W images showed high SI in two cases and heterogeneous-mixed in seven cases. Enhancement was heterogeneous in six and homogeneous in four lesions. Patchy unenhanced areas (on CT and T1W MR images) along with patchy areas of low  to markedly high SI on T2W images were depicted in 19 lesions. The enhanced portions correlated to areas of increased vascularity and cellularity. The four clinically more aggressive lesions could not be predicted on imaging. CONCLUSION: Typical soft tissue SFTs are deep masses made of isodense and isointense areas relative to adjacent muscles mixed with hypodense and hypointense areas on unenhanced CT and MR T1W respectively. Variable enhancement patterns and mixed to high signal intensities on MRT2W are attributed to tumor’s cellularity, vascularity, collagen distribution and/or degeneration. Heterogeneity of SFTs affects imaging features on MRI and CT modalities. The biological behavior of soft tissue SFTs can not be predicted based solely either on histopathologic or imaging evaluation.

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[645]

TÍTULO / TITLE:  - MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genome Med. 2013 Jan 22;5(1):2.

            ●● Enlace al texto completo (gratuito o de pago) 1186/gm406

AUTORES / AUTHORS:  - Kelly AD; Haibe-Kains B; Janeway KA; Hill KE; Howe E; Goldsmith J; Kurek K; Perez-Atayde AR; Francoeur N; Fan JB; April C; Schneider H; Gebhardt MC; Culhane A; Quackenbush J; Spentzos D

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: Although microRNAs (miRNAs) are implicated in osteosarcoma  biology and chemoresponse, miRNA prognostic models are still needed, particularly since prognosis is imperfectly correlated with chemoresponse. Formalin-fixed, paraffin-embedded (FFPE) tissue is a necessary resource for biomarker studies in  this malignancy with limited frozen tissue availability. METHODS: We performed miRNA and mRNA microarray FFPE assays in 65 osteosarcoma biopsy and 26 paired post-chemotherapy resection specimens and used the only publicly available miRNA  dataset, generated independently by another group, to externally validate our strongest findings (n=29). We used supervised principal components analysis and logistic regression for survival and chemoresponse, and miRNA activity and target gene set analysis to study miRNA regulatory activity. RESULTS: Several miRNA-based models with as few as 5 miRNAs were prognostic independently of pathologically assessed chemoresponse (median RFS: 59 months vs. not-yet-reached; adjusted HR=2.90; p=0.036). The independent dataset supported the reproducibility of recurrence and survival findings. The prognostic value of the profile was independent of confounding by known prognostic variables, including chemoresponse, tumor location, and metastasis at diagnosis. Model performance improved when chemoresponse was added as a covariate (median RFS: 59 vs. not-yet-reached; HR=3.91; p=0.002). Most prognostic miRNAs are located at 14q32 - a locus already linked to osteosarcoma - and their gene targets display deregulation patterns associated with outcome. We also identified miRNA profiles  predictive of chemoresponse (75-80% accuracy), which did not overlap with prognostic profiles. CONCLUSIONS: FFPE tissue-derived miRNA patterns are a powerful prognostic tool for risk-stratified osteosarcoma management strategies.  Combined miRNA/mRNA analysis supports a possible role of the 14q32 locus in osteosarcoma progression and outcome. Our study creates a paradigm for FFPE-based miRNA biomarker studies in cancer.

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[646]

TÍTULO / TITLE:  - Current management and prognostic features for gastrointestinal stromal tumor (GIST).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Hematol. Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://www.medicinedirect.com/journal 

            ●● Cita: Experimental Hematology: <> Oncol. 2012 Jun 18;1(1):14. doi: 10.1186/2162-3619-1-14.

            ●● Enlace al texto completo (gratuito o de pago) 1186/2162-3619-1-14

AUTORES / AUTHORS:  - Lamba G; Gupta R; Lee B; Ambrale S; Liu D

INSTITUCIÓN / INSTITUTION:  - Division of Oncology/Hematology, New York Medical College and Westchester Medical Center, Valhalla, NY, 10595, USA. delong_liu@nymc.edu.

RESUMEN / SUMMARY:  - ABSTRACT: Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI) tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years. Gastrointestinal stromal tumors (GIST) account for approximately 1% to 3% of all  malignant GI tumors. The clinical features can vary depending on the anatomic location, size and aggressiveness of the tumor. Metastatic GIST represents a successful example of molecular targeted therapy. In this comprehensive review, we discuss the epidemiology, clinical features and diagnostic modalities for GIST. We also describe treatment options for early stage, locally advanced and metastatic GIST. Indications for neoadjuvant and adjuvant therapy along with duration of therapy are also explained. A brief discussion of latest biomarkers and updates from recent meetings is also provided.

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[647]

TÍTULO / TITLE:  - NPRL2 is an independent prognostic factor of osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Biomark. 2012 Jan 1;12(1):31-6. doi: 10.3233/CBM-120290.

            ●● Enlace al texto completo (gratuito o de pago) 3233/CBM-120290

AUTORES / AUTHORS:  - Gao Y; Wang J; Fan G

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, The First Affiliated Hospital, Liaoning Medical University, Jinzhou, Liaoning, China.

RESUMEN / SUMMARY:  - NPRL2 is a tumor suppressor gene whose inactivation contributes to tumor development. However, NPRL2 expression in osteosarcoma remains unclear. This study aimed to assess NPRL2 expression in osteosarcoma and analyze its potential  as a prognostic factor. NPRL2 expression in 48 cases of osteosarcoma and 40 cases of osteochondroma tumors was examined by immunohistochemistry. NPRL2 expression in 20 osteosarcoma and 20 osteochondroma specimens were detected by Real-time PCR and Western blot analysis. We found that 18 cases (37.5%) of osteosarcoma and 27  cases (67.5%) of osteochondroma showed positive NPRL2 expression. Real-Time PCR and Western blot analysis showed that NRPL2 expression was lower in osteosarcoma  than in osteochondroma (p< 0.05). The positive rate of NPRL2 expression was 71.4% (10/14), 25% (4/16) and 16.7% (3/18) in stage I, II and III of osteosarcoma, respectively. The positive rate of NPRL2 was 19% (4/21) and 48.1% (13/27) for low grade and high grade of osteosarcoma, respectively, with significant difference (p< 0.05). Cox multivariate analysis showed that the value of NPRL2 for predicting the overall survival of osteosarcoma patients. Despite the small size  of the samples, our results suggest that NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma.

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[648]

TÍTULO / TITLE:  - Recurrent Dermatofibrosarcoma Protuberans of the Shoulder with Rare Distant Abdominal Metastasis detected by Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography (FDG-PET/CT).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sultan Qaboos Univ Med J. 2012 Aug;12(3):371-4. Epub 2012 Jul 15.

AUTORES / AUTHORS:  - Al-Tamimi A; Zaheer S; Pierce CK; Osmany S; Sittampalam K

INSTITUCIÓN / INSTITUTION:  - Departments of Nuclear Medicine & PET.

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[649]

TÍTULO / TITLE:  - Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Front Med. 2012 Dec;6(4):395-405. doi: 10.1007/s11684-012-0231-5. Epub 2012 Dec 7.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11684-012-0231-5

AUTORES / AUTHORS:  - Meraj R; Wikenheiser-Brokamp KA; Young LR; Byrnes S; McCormack FX

INSTITUCIÓN / INSTITUTION:  - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45529, USA.

RESUMEN / SUMMARY:  - Pulmonary lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that targets women during their reproductive years. A confident diagnosis can often be based on clinical grounds, but diagnostic certainty requires pathological analysis. Although surgical lung biopsy is considered the gold standard for obtaining tissue in patients with diffuse lung disease, it is also associated with higher morbidity and mortality than alternative, less invasive techniques. The objective of our study was to examine the utility of transbronchial biopsy in the diagnosis of LAM. We conducted two online surveys of over 1,000 LAM patients  registered with the LAM Foundation who were accessible by email. Transbronchial biopsy specimens were subsequently collected and reviewed by an expert pathologist to validate the diagnosis. We found that transbronchial biopsy has a  yield of approximately 60% in patients with LAM. We conclude that transbronchial  biopsy may be a safe and effective method for establishing the diagnosis of LAM,  obviating the need for surgical lung biopsy in more than half of LAM patients.

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[650]

TÍTULO / TITLE:  - Short Hairpin RNA (shRNA) Ether a go-go 1 (Eag1) Inhibition of Human Osteosarcoma Angiogenesis via VEGF/PI3K/AKT Signaling.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Mol Sci. 2012 Oct 1;13(10):12573-83. doi: 10.3390/ijms131012573.

            ●● Enlace al texto completo (gratuito o de pago) 3390/ijms131012573

AUTORES / AUTHORS:  - Wu J; Wu X; Zhong D; Zhai W; Ding Z; Zhou Y

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, The Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, China. quangao175th@163.com.

RESUMEN / SUMMARY:  - Ether a go-go 1 (Eag1) channel is overexpressed in a variety of cancers but the therapeutic potential of Eag1 in osteosarcoma remains elusive. In this study, we  constructed an Ad5-Eag1-shRNA vector and evaluated its efficiency for Eag1 knockdown and its effects on osteosarcoma. Our results showed that Ad5-Eag1-shRNA had high interference efficiency of Eag1 expression and suppressed osteosarcoma growth both in vitro and in vivo. To explore the molecular mechanism underlying tumor growth inhibition induced by Eag1 silencing, the intratumoral microvessel density (MVD) was assessed by CD31 staining and the expression of vascular endothelial growth factor (VEGF) was detected by Western blot analysis. We found  that Eag1 silencing led to decreased angiogenesis and VEGF expression in the xenograft model of osteosarcoma. Finally, we detected a time-dependent decrease in VEGF expression and considerably reduced phosphoinositide 3-kinase (PI3K) and  protein kinase B (AKT) activation in osteosarcoma cells treated by Eag1 shRNA. Taken together, our results suggest that Eag1 silencing inhibits tumor growth and angiogenesis in osteosarcoma via the down regulation of VEGF/PI3K/AKT signaling.

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[651]

TÍTULO / TITLE:  - Soft tissue sarcomas-the pitfalls in diagnosis and management!!

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):261-4. doi: 10.1007/s13193-012-0141-7. Epub 2012 Mar 10.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-012-0141-7

AUTORES / AUTHORS:  - Chintamani

INSTITUCIÓN / INSTITUTION:  - VMMC, Safdarjang Hospital, New Delhi, 110023 India.

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[652]

TÍTULO / TITLE:  - Diagnostics of peripherally located intrathoracic lipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Acta Inform Med. 2012 Jun;20(2):129-30. doi: 10.5455/aim.2012.20.129-130.

            ●● Enlace al texto completo (gratuito o de pago) 5455/aim.2012.20.129-130

AUTORES / AUTHORS:  - Yildirim M; Parlak E; Koroglu M; Koksal S; Yildiz M; Gurses C

INSTITUCIÓN / INSTITUTION:  - Antalya Education and Research Hospital, Department of Medical Oncology, Antalya, Turkey.

RESUMEN / SUMMARY:  - In the differential diagnosis of lipomas, fibromatous hamartoma, liposarcoma, fibrolipoma and teratoma may be mentioned as fat-containing lesions of peripheral localization. However, these lesions are different from lipomas in that they contain soft tissue components and are not homogeneous. Furthermore, they are much larger than lipomas, are infiltrative and their CT density is greater than -50 HU. Though it is emphsized that up to the present time surgery has been the gold standard method in the recognition and treatment, considering the risks of surgical procedures, we are of the opinion that diagnosis can be established and  the follow-up can be managed with advanced radiological methods and that there is no necessity for invasive interventions especially in asymptomatic patients.

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[653]

TÍTULO / TITLE:  - FNA diagnosis of osteoclast-like giant cell tumor of the pancreas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cytol. 2012 Oct;29(4):270-2. doi: 10.4103/0970-9371.103951.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0970-9371.103951

AUTORES / AUTHORS:  - Sivanandham S; Subashchandrabose P; Muthusamy KR

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.

RESUMEN / SUMMARY:  - Osteoclast-like giant cell tumor of the pancreas is a rare non-endocrine neoplasm composed of reactive multinucleated giant cells admixed with mononuclear stromal  cells. We report a case of osteoclast-like giant cell tumor of the pancreas in a  58-year-old female with vague clinical symptoms. Endoscopic ultrasound-guided aspirate from the mass revealed numerous characteristic osteoclast-like giant cells.

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[654]

TÍTULO / TITLE:  - Atypical atrial myxoma pending to the left atrial appendage: a diagnostic challenge.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 3;2013. pii: bcr2012007850. doi: 10.1136/bcr-2012-007850.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007850

AUTORES / AUTHORS:  - Faustino A; Providencia R; Trigo J; Cachulo Mdo C

INSTITUCIÓN / INSTITUTION:  - Department of Cardiology, Coimbra’s Hospital Centre and University, Coimbra, Portugal.

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[655]

TÍTULO / TITLE:  - Hepatic angiomyolipoma: diagnostic findings and management.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Hepatol. 2012;2012:410781. doi: 10.1155/2012/410781. Epub 2012 Dec 23.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/410781

AUTORES / AUTHORS:  - Kamimura K; Nomoto M; Aoyagi Y

INSTITUCIÓN / INSTITUTION:  - Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1-757, Chuo-ku, Niigata 951-8122, Japan.

RESUMEN / SUMMARY:  - Angiomyolipoma (AML) is a benign mesenchymal tumor that is frequently found in the kidney and, rarely, in the liver. The natural history of hepatic AML has not  been clarified, and, because of the similar patterns in imaging studies, such as  ultrasonography, computed tomography, and magnetic resonance imaging, some of these tumors have been overdiagnosed as hepatocellular carcinoma in the past. With an increase in the number of case reports showing detailed imaging studies and immunohistochemical staining of the tumor with human melanoma black-45, the diagnostic accuracy is also increasing. In this paper, we focused on the role of  noninvasive imaging studies and histological diagnosis showing distinctive characteristics of this tumor. In addition, because several reports have described tumor progression in terms of size, recurrence after surgical resection, metastasis to other organs, and portal thrombosis, we summarized these cases for the management and discussed the indications for the surgical treatment of this tumor.

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[656]

TÍTULO / TITLE:  - Multiplexed colorimetric detection of Kaposi’s sarcoma associated herpesvirus and Bartonella DNA using gold and silver nanoparticles.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Nanoscale. 2013 Jan 22.

            ●● Enlace al texto completo (gratuito o de pago) 1039/c3nr33492a

AUTORES / AUTHORS:  - Mancuso M; Jiang L; Cesarman E; Erickson D

INSTITUCIÓN / INSTITUTION:  - Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma (KS) is an infectious cancer occurring most commonly in human immunodeficiency virus (HIV) positive patients and in endemic regions, such as Sub-Saharan Africa, where KS is among the top four most prevalent cancers. The cause of KS is the Kaposi’s sarcoma-associated herpesvirus (KSHV, also called HHV-8), an oncogenic herpesvirus that while routinely diagnosed in developed nations, provides challenges to developing world medical providers and point-of-care detection. A major challenge in the diagnosis of KS is the existence of a number of other diseases with similar clinical presentation and histopathological features, requiring the detection of KSHV in a biopsy sample. In this work we develop an answer to this challenge by creating a multiplexed one-pot detection system for KSHV DNA and DNA from a frequently confounding disease, bacillary angiomatosis. Gold and silver nanoparticle aggregation reactions are tuned for each target and a multi-color change system is developed  capable of detecting both targets down to levels between 1 nM and 2 nM. The system developed here could later be integrated with microfluidic sample processing to create a final device capable of solving the two major challenges in point-of-care KS detection.

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[657]

TÍTULO / TITLE:  - Congenital spinal lipomas: Role of prophylactic surgery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Neurosci. 2012 May;7(2):85-9. doi: 10.4103/1817-1745.102562.

            ●● Enlace al texto completo (gratuito o de pago) 4103/1817-1745.102562

AUTORES / AUTHORS:  - Kumar A; Mahapatra AK; Satyarthee GD

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Cardioneurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

RESUMEN / SUMMARY:  - INTRODUCTION: Congenital spinal lipomas constitute an important group of lesions  causing tethered cord syndrome. Management of these lesions is challenging and role of prophylactic surgery for these lesions is still controversial. Hence, current study was undertaken with the aim to evaluate the role of prophylactic surgery in the management of these lesions. MATERIALS AND METHODS: A total of 147 consecutive patients, treated over a period of 10 years (January 2001-December 2010), are retrospectively analyzed. RESULTS: In our study, 93 patients had conus lipomas, 26 had filum lipomas and 28 had only lipomeningomyelocele. Boys and girls were almost equally represented. The age of patients at the time of surgery ranged from 15 days to 34 years with an average of 62 months (5.2 years). Neurological deficits were present in 101 (68) patients. The patients with neurological deficits were older in comparison to those neurologically intact (average age 6.2 versus 2.8 years, respectively). Difference in age between the two groups was statistically significant (P value 0.03). Neurological deterioration was observed in 8 (5) patients following surgery, out of which six  patients developed transient deterioration and only two, had persisting deficits. None of the neurologically asymptomatic patients developed persistent neurological deficits. In the symptomatic group, nine patients (9) showed improvement in neurological status after surgery. CONCLUSIONS: In author’s view,  prophylactic surgery for congenital spinal lipomas is safe and effective. However, a well designed randomized controlled trial, to definitely and objectively prove the usefulness of prophylactic surgery is needed.

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[658]

TÍTULO / TITLE:  - Inhibition of fatty acid synthase suppresses osteosarcoma cell invasion and migration via downregulation of the PI3K/Akt signaling pathway in vitro.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Mol Med Report. 2013 Feb;7(2):608-12. doi: 10.3892/mmr.2012.1220. Epub 2012 Dec 3.

            ●● Enlace al texto completo (gratuito o de pago) 3892/mmr.2012.1220

AUTORES / AUTHORS:  - Liu ZL; Mao JH; Peng AF; Yin QS; Zhou Y; Long XH; Huang SH

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, First Affiliated Hospital of Nanchang University, Nanchang 330006, P.R. China.

RESUMEN / SUMMARY:  - In the present study, the effect of fatty acid synthase (FASN) inhibition on cell invasion and migration in vitro was investigated. A recombinant plasmid containing a microRNA targeting the FASN gene was used to inhibit FASN expression in U2OS cells. Cell migration and invasion were investigated using wound healing  and Transwell invasion assays. We found that cell invasion and migration were suppressed by inhibiting FASN. In addition, the effect of inhibition of FASN on phosphorylation of Akt was investigated by detecting the expression levels of pAkt using western blot analysis. Furthermore, protein expression levels of nuclear factorkappaB (NFkappaB; p65) and matrix metalloproteinase (MMP)2 and 9 were also measured by western blot analysis. Results demonstrated that expression levels of pAkt, NFkappaB (p65) and MMP2 and 9 proteins were reduced significantly by inhibiting FASN. Therefore, we confirmed that inhibition of FASN by RNA interference suppresses osteosarcoma cell metastasis via downregulation of the phosphoinositide 3kinase/Akt/NFkappaB signaling pathway in vitro.

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[659]

TÍTULO / TITLE:  - Proliferation and osteoblastic differentiation of hMSCs on cellulose-based hydrogels.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Appl Biomater Function Mater. 2012 Dec 13;10(3):302-307. doi: 10.5301/JABFM.2012.10366.

            ●● Enlace al texto completo (gratuito o de pago) 5301/JABFM.2012.10366

AUTORES / AUTHORS:  - Raucci MG; Alvarez-Perez MA; Demitri C; Sannino A; Ambrosio L

INSTITUCIÓN / INSTITUTION:  - Institute of Composite and Biomedical Materials, National Research Council of Italy, Naples - Italy.

RESUMEN / SUMMARY:  - Purpose: The aim of this project was to study the proliferation and differentiation of human Mesenchymal Stem Cells (hMSCs) onto a cellulose-based hydrogel for bone tissue engineering.Methods: Modified-cellulose hydrogel was prepared via double esterification crosslinking using citric acid. The response of human Mesenchymal Stem Cells (hMSCs) in terms of cell proliferation and differentiation into osteoblastic phenotype was evaluated by using Alamar blue assay and Alkaline phosphatase activity. Results: The results showed that CMCNa and CMCNa_CA have no negative effect on hMSC, adhesion and proliferation. Moreover, the increase of the ALP expression for CMCNa_CA confirms the ability of the hydrogels to support the osteoblastic differentiation.Conclusions: The cellulose-based hydrogels have a potential application as filler in bone tissue regeneration.

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[660]

TÍTULO / TITLE:  - Increased healthy osteoblast to osteosarcoma density ratios on specific PLGA nanopatterns.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Nanomedicine. 2013;8:159-66. doi: 10.2147/IJN.S36408. Epub 2013 Jan 7.

            ●● Enlace al texto completo (gratuito o de pago) 2147/IJN.S36408

AUTORES / AUTHORS:  - Wang Y; Zhang L; Sun L; Webster TJ

INSTITUCIÓN / INSTITUTION:  - Department of Chemistry, Brown University, Providence, RI, USA.

RESUMEN / SUMMARY:  - Poly(lactic-co-glycolic acid) ([PLGA] 50:50 wt% PLA:PGA) films with a flat surface and with 27 nm, 190 nm, 300 nm, 400 nm, and 520 nm nanopatterns were fabricated using a cast-mold process. The nanopatterns were transferred from self-assembled polystyrene (PS) beads to PLGA films through polydimethylsiloxane  (PDMS) molds. The surface features, root-mean- square (RMS) roughness, and wettability of these PLGA surface features were studied by atomic force microscope (AFM) height scans, AFM z-sensor scans, and water contact angles, respectively. In order to evaluate the influence of the material topography alone (without changes in chemistry) for bone-cancer applications, both human healthy osteoblasts and human cancerous osteosarcoma cells were cultured on these PLGA surface features, and their densities were determined. Most importantly, compared to all other substrates, it was found that the 27 nm PLGA nanopatterns significantly increased the healthy osteoblast-to-osteosarcoma cell-density ratio. For these reasons, and since previous studies have highlighted that similar nanometer PLGA surface features decreased functions of other types of cancerous cells (specifically lung and breast), this study suggests that 27 nm PLGA nanopatterns should be further studied for a wide range of bone-cancer applications, particularly where healthy bone-cell functions need to be promoted  over cancerous bone-cell functions.

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[661]

TÍTULO / TITLE:  - Oral metastasis of chondroblastic osteosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Contemp Clin Dent. 2012 Jul;3(3):367-9. doi: 10.4103/0976-237X.103640.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0976-237X.103640

AUTORES / AUTHORS:  - Dumpala RK; Guttikonda VR; Yeluri S; Madala J

INSTITUCIÓN / INSTITUTION:  - Department of Oral Pathology and Microbiology, Mamata Dental College, Khammam, Andhra Pradesh, India.

RESUMEN / SUMMARY:  - Osteosarcoma is the most common primary malignant mesenchymal tumor, accounting for approximately 20% of sarcomas, with 5% incidence in the jaws. They present various clinical and histological aspects as well as variable disease prognosis and outcome. About 50% of all osteosarcomas are osteoblastic, 25% fibroblastic, 25% chondroblastic. Metastasis of osteosarcoma in the oral cavity is rare, and very few cases have been described so far in the literature. This article presents a metastatic case of chondroblastic osteosarcoma in the mandibular right-attached gingiva arising from 4(th) rib. This case report further suggests  that chondroblastic osteosarcoma has poor prognosis.

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[662]

TÍTULO / TITLE:  - Microscopic diversity in oral Kaposi sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Feb;115(2):241-8. doi: 10.1016/j.oooo.2012.11.009.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.oooo.2012.11.009

AUTORES / AUTHORS:  - Bunn BK; Carvalho Mde V; Louw M; Vargas PA; van Heerden WF

INSTITUCIÓN / INSTITUTION:  - Oral Pathologist, Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, South Africa.

RESUMEN / SUMMARY:  - Kaposi sarcoma is the most common HIV-associated neoplasm, frequently presenting  with oral mucosal involvement. This retrospective study aimed to assess and highlight the histomorphological spectrum of oral Kaposi sarcoma. A total of 135  cases diagnosed between 1990 and 2011 were retrieved from the archives of the Oral and Dental Hospital of the University of Pretoria, South Africa. Following histologic review, each case was placed into 1 of 7 categories based on the predominant pattern of growth. These histologic divisions included lesions designated as solid, lymphangioma-like, telangiectatic, desmoplastic, lymphangiectatic, ecchymotic, and anaplastic. The presence of coexistent pathology was identified in 25 cases, largely represented by superimposed candidiasis. Concomitant cytomegalovirus and non-necrotizing granulomatous inflammation were also observed. Although the prognostic significance of these variants is yet to be determined, the appreciation and recognition of such morphologic diversity remains essential in distinguishing these lesions from possible mimickers.

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[663]

TÍTULO / TITLE:  - 1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human Chondrosarcoma through Intrinsic and Extrinsic Pathways.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Mol Sci. 2012 Dec 4;13(12):16472-88. doi: 10.3390/ijms131216472.

            ●● Enlace al texto completo (gratuito o de pago) 3390/ijms131216472

AUTORES / AUTHORS:  - Liu JF; Huang YL; Yang WH; Chang CS; Tang CH

INSTITUCIÓN / INSTITUTION:  - Central Laboratory, Shin Kong Wu Ho-Su Memorial Hospital, No.95, Wunchang Road, Shihlin District, Taipei City 111, Taiwan. chtang@mail.cmu.edu.tw.

RESUMEN / SUMMARY:  - In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo efficacy was examined in a JJ012 xenograft model. Here we found that BPB induced apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353) but not in primary chondrocytes. BPB induced upregulation of Bax, Bad and Bak, downregulation of Bcl-2, Bid and Bcl-XL and dysfunction of mitochondria in chondrosarcoma. In addition, BPB also promoted cytosolic releases AIF and Endo G. Furthermore, it triggered extrinsic death receptor-dependent pathway, which was characterized by activating Fas, FADD and caspase-8. Most importantly, animal studies revealed a dramatic 40% reduction in tumor volume after 21 days of treatment. Thus, BPB may be a novel anticancer agent for the treatment of chondrosarcoma.

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[664]

TÍTULO / TITLE:  - Adrenal lipoma with hemorrhage: a cause of abdominal pain.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Urol J. 2012 Fall;9(4):721-4.

AUTORES / AUTHORS:  - Jain D; Chopra P; Sharma A

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Sir Ganga Ram Hospital, New Delhi, India. deepalijain76@gmail.com

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[665]

TÍTULO / TITLE:  - Influence of the Internalization Pathway on the Efficacy of siRNA Delivery by Cationic Fluorescent Nanodiamonds in the Ewing Sarcoma Cell Model.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2012;7(12):e52207. doi: 10.1371/journal.pone.0052207. Epub 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0052207

AUTORES / AUTHORS:  - Alhaddad A; Durieu C; Dantelle G; Le Cam E; Malvy C; Treussart F; Bertrand JR

INSTITUCIÓN / INSTITUTION:  - Vectorologie et therapeutiques anti-cancereuses, CNRS UMR 8203, Universite Paris  Sud 11, Institut Gustave Roussy, Villejuif, France.

RESUMEN / SUMMARY:  - Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to facilitate cell penetration and to prevent siRNA degradation by nucleases. We have shown that diamond nanocrystals coated with cationic polymer can be used to carry siRNAs into Ewing sarcoma cells, in which they remain traceable over long periods, due to their intrinsic stable fluorescence. We tested two cationic polymers, polyallylamine and polyethylenimine. The release of siRNA, accompanied  by Ewing sarcoma EWS-Fli1 oncogene silencing, was observed only with polyethylenimine. We investigated cell penetration and found that the underlying  mechanisms accounted for these differences in behavior. Using drugs selectively inhibiting particular pathways and a combination of fluorescence and electronic microscopy, we showed that siRNA gene silencing occurred only if the siRNA:cationic nanodiamond complex followed the macropinocytosis route. These results have potential implications for the design of efficient drug-delivery vectors.

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[666]

TÍTULO / TITLE:  - Updates on the cytogenetics and molecular cytogenetics of benign and intermediate soft tissue tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2013 Jan;5(1):12-18. Epub 2012 Oct 30.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.1002

AUTORES / AUTHORS:  - Nishio J

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.

RESUMEN / SUMMARY:  - SOFT TISSUE TUMORS ARE CLASSIFIED ACCORDING TO THEIR HISTOLOGICAL RESEMBLANCE TO  NORMAL ADULT TISSUES AND CAN BE GROUPED INTO THE FOLLOWING CATEGORIES BASED ON METASTATIC POTENTIAL: benign, intermediate (locally aggressive), intermediate (rarely metastasizing) and malignant. Over the past two decades, considerable progress has been made in our understanding of the genetic background of soft tissue tumors. Traditional laboratory techniques, such as cytogenetic analysis and fluorescence in situ hybridization (FISH), can be used for diagnostic purposes in soft tissue pathology practice. Moreover, cytogenetic and molecular studies are often necessary for prognostics and follow-up of soft tissue sarcoma  patients. This review provides updated information on the applicability of laboratory genetic testing in the diagnosis of benign and intermediate soft tissue tumors. These tumors include nodular fasciitis, chondroid lipoma, collagenous fibroma (desmoplastic fibroblastoma), giant cell tumor of tendon sheath (GCTTS)/pigmented villonodular synovitis (PVNS), angiofibroma of soft tissue, myxoinflammatory fibroblastic sarcoma (MIFS) and ossifying fibromyxoid tumor (OFMT).

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[667]

TÍTULO / TITLE:  - Alveolar rhabdomyosarcoma—The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Skelet Muscle. 2012 Dec 3;2(1):25.

            ●● Enlace al texto completo (gratuito o de pago) 1186/2044-5040-2-25

AUTORES / AUTHORS:  - Marshall AD; Grosveld GC

RESUMEN / SUMMARY:  - ABSTRACT: Rhabdomyosarcoma is a soft tissue sarcoma arising from cells of a mesenchymal or skeletal muscle lineage. Alveolar rhabdomyosarcoma (ARMS) is more  aggressive than the more common embryonal (ERMS) subtype. ARMS is more prone to metastasis and carries a poorer prognosis. In contrast to ERMS, the majority of ARMS tumors carry one of several characteristic chromosomal translocations, such  as t(2;13)(q35;q14), which results in the expression of a PAX3-FOXO1 fusion transcription factor. In this review we discuss the genes that cooperate with PAX3-FOXO1, as well as the target genes of the fusion transcription factors that  contribute to various aspects of ARMS tumorigenesis. The characterization of these pathways will lead to a better understanding of ARMS tumorigenesis and will allow the design of novel targeted therapies that will lead to better treatment for this aggressive pediatric tumor.

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[668]

TÍTULO / TITLE:  - HIV-1 Tat Promotes Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) vIL-6-Induced Angiogenesis and Tumorigenesis by Regulating PI3K/PTEN/AKT/GSK-3beta Signaling Pathway.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2013;8(1):e53145. doi: 10.1371/journal.pone.0053145. Epub 2013 Jan 2.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0053145

AUTORES / AUTHORS:  - Zhou F; Xue M; Qin D; Zhu X; Wang C; Zhu J; Hao T; Cheng L; Chen X; Bai Z; Feng N; Gao SJ; Lu C

INSTITUCIÓN / INSTITUTION:  - State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People’s Republic of China ; Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, People’s Republic of China ; Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, People’s Republic of China ; Department of Pathogenic Biology and Immunology, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China.

RESUMEN / SUMMARY:  - Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most common AIDS-related malignancy. KS is characterized by vast angiogenesis and hyperproliferative spindle cells. We have previously reported that HIV-1 Tat can trigger KSHV reactivation and accelerate Kaposin A-induced tumorigenesis. Here, we explored Tat promotion of KSHV vIL-6-induced angiogenesis and tumorigenesis. Tat promotes vIL-6-induced cell proliferation, cellular transformation, vascular tube formation and VEGF production in culture. Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells in a chicken chorioallantoic membrane (CAM) model. In an allograft model, Tat promotes vIL-6-induced tumorigenesis and expression of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1. Mechanistic studies indicated Tat activates PI3K and AKT, and inactivates PTEN and GSK-3beta in vIL-6 expressing cells. LY294002, a specific inhibitor of PI3K, effectively impaired Tat’s promotion of vIL-6-induced tumorigenesis. Together, these results provide the first evidence that Tat might contribute to KS pathogenesis by synergizing with vIL-6, and identify PI3K/AKT pathway as a potential therapeutic target in AIDS-related KS patients.

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[669]

TÍTULO / TITLE:  - CT findings of a gastrointestinal stromal tumor arising from small bowel.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Quant Imaging Med Surg. 2012 Mar;2(1):57-8. doi: 10.3978/j.issn.2223-4292.2012.01.01.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2223-4292.2012.01.01

AUTORES / AUTHORS:  - Gong JS; Kang WY; Liu T; Zhu J; Xu JM

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Shenzhen People’s Hospital, Jinan University Second Clinical Medical College, Shenzhen, 518020, Guangdong Province, China.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the gastrointestinal tract, arise from interstitial cells of Cajal. Most of them  are composed of spindle cells and mimic leiomyoma morphologically. Nearly all GISTs demonstrate positive staining for CD-117 at immunohistochemistry examination, which helps to distinguish them from true leiomyomas. We describe the CT findings of a GIST of small bowel. At plain CT scan, the tumor was of homogeneous iso-attenuation. After intravenous administration of contrast materials, a well-defined exophytic growth mass with avid homogeneous enhancement was demonstrated. The mucosal layer over the mass was intact and fat plane between the mass and adjacent GI wall was preserved. A diagnosis of GIST was suggested and was then confirmed by positive staining for CD-117.

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[670]

TÍTULO / TITLE:  - Large left atrial myxoma in an oligosymptomatic young woman.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hellenic J Cardiol. 2013 Jan;54(1):60-3.

AUTORES / AUTHORS:  - Lazaros G; Masoura C; Brili S; Stavropoulos G; Kafiri G; Stefanadis C

INSTITUCIÓN / INSTITUTION:  - First Department of Cardiology, University of Athens Medical School, Hippokration Hospital, Athens, Greece.

RESUMEN / SUMMARY:  - We present the case of a young female with a large sporadic left atrial myxoma. Interestingly, despite the tumor’s large size, this patient had only mild exertional dyspnea without any embolic events or constitutional symptoms.

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[671]

TÍTULO / TITLE:  - Desmoplastic fibroma of the cranium in a young man.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Korean Neurosurg Soc. 2012 Dec;52(6):561-3. doi: 10.3340/jkns.2012.52.6.561. Epub 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 3340/jkns.2012.52.6.561

AUTORES / AUTHORS:  - Lee S; Jung SM; Cho BK; Kim H

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, College of Medicine, Seoul National University, Seoul, Korea.

RESUMEN / SUMMARY:  - Desmoplastic fibroma, which develops predominantly in long bones and the mandible, is a rare and benign but locally aggressive tumor. Desmoplastic fibroma of the cranium is extremely rare. We report a case of desmoplastic fibroma of the frontal bone in a young man. Because of its locally aggressive behavior, complete surgical excision with a safety margin is essential.

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[672]

TÍTULO / TITLE:  - Gastrointestinal stromal tumour (GIST) in a young man with unprovoked haematemesis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 8;2013. pii: bcr2012008018. doi: 10.1136/bcr-2012-008018.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-008018

AUTORES / AUTHORS:  - Shahnazarian V; Fazio L

INSTITUCIÓN / INSTITUTION:  - Ross University School of Medicine, North Brunswick, New Jersey, USA.

RESUMEN / SUMMARY:  - This case involves a 27-year-old Hispanic man who presented to the emergency department with two episodes of haematemesis with no other associated symptoms. In addition, he has no medical history, denies alcohol abuse, denies non-steroidal anti-inflammatory drug use and has never experienced these episodes before. Esophagogastroduodenoscopy evaluation showed a large gastric mass, and histological results obtained from several biopsies of the mass supported a diagnosis of gastrointestinal stromal tumour. His abdominal CT scan also supported this finding. However, the unprovoked haematemesis and young age of the patient does not fit the typical presentation of a gastrointestinal stromal tumour.

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[673]

TÍTULO / TITLE:  - Transforming growth factor beta repressor, SnoN, is overexpressed in human gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J BUON. 2012 Oct-Dec;17(4):684-90.

AUTORES / AUTHORS:  - Bravou V; Papanastasopoulos P; Verras D; Kotsikogianni I; Damaskou V; Repanti M

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, General Hospital of Patras “Agios Andreas”, Patras, Greece.

RESUMEN / SUMMARY:  - Purpose: The transforming growth factor bgr; (TGF-beta)/ Smad pathway is implicated in the development of interstitial cells of Cajal. The aim of this study was to examine the role of this pathway in human gastrointestinal stromal tumors (GISTs). Methods: The expression of TGF-beta receptor II (TbetaRII), phosphorylated Smad2 (p-Smad2), SnoN, p21(WAF17sol;CIP1) and p27(KIP1) was examined by immunohistochemistry in 30 hu-man GISTs in relation to prognostic factors. Results: TbetaRII was expressed in 76.9% of the cases. All cases were positive for p-Smad2 and SnoN, with significantly higher expression levels in small intestinal compared to gastric GISTs. Downregulation of p21(WAF1/CIP1) and  p27(KIP1) was found in 78.6% and 46.4% of the cases respectively, while cytoplasmic expression of p27(KIP1) was also noted in 50% of GISTs. Conclusions:  TGF-beta/Smad pathway may contribute to GIST pathogenesis. SnoN overexpression and low levels of p21(WAF1)/CIP1 and p27(KIP1) may be of importance in GISTs.

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[674]

TÍTULO / TITLE:  - Primary pulmonary synovial sarcoma in pregnancy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Obstet Gynecol. 2012;2012:326031. doi: 10.1155/2012/326031. Epub 2012 Nov 7.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/326031

AUTORES / AUTHORS:  - Bunch K; Deering SH

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, WA  98431, USA.

RESUMEN / SUMMARY:  - Background. Primary pulmonary synovial sarcoma is a rare malignancy with a poor prognosis. Surgical resection and postoperative management of these tumors has not been previously described in pregnancy. Case. A 38-year-old pregnant woman was admitted for evaluation of a right thoracic mass found on chest radiography at 26 weeks of gestation. A computed tomography-guided biopsy was subsequently completed and demonstrated a high-grade neoplasm. A right pneumonectomy was performed at 28 weeks of gestation due to pulmonary decompensation, and pathological examination revealed a pulmonary synovial sarcoma. The patient developed a postpartum pulmonary embolism and expired 6 weeks after delivery. Conclusion. Aggressive intervention for pulmonary malignancies during pregnancy may be necessary. Complete tumor resection is the most important prognostic factor in primary pulmonary synovial sarcoma.

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[675]

TÍTULO / TITLE:  - Symptomatic hibernoma: a rare soft tissue tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hawaii J Med Public Health. 2012 Dec;71(12):342-5.

AUTORES / AUTHORS:  - Derosa DC; Lim RB; Lin-Hurtubise K; Johnson EA

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, Tripler Army Medical Center, Honolulu, HI.

RESUMEN / SUMMARY:  - Hibernomas are benign soft tissue tumors containing prominent brown adipocytes that resemble normal brown fat. Hibernomas have not been associated with malignant potential; however, they are similar in clinical presentation to malignant tumors like liposarcomas. This article describes the clinical, radiographic, and histologic features of a patient with a hibernoma arising from  the left superior flank.

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[676]

TÍTULO / TITLE:  - The effect of uterine fibroid embolization on lower urinary tract symptoms.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int Urogynecol J. 2012 Dec 18.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00192-012-2013-7

AUTORES / AUTHORS:  - Shveiky D; Iglesia CB; Antosh DD; Kudish BI; Peterson J; Huang CC; Spies JB

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics & Gynecology, Hadassah-Hebrew University Medical Center, Ein Kerem, PO Box 12000, Jerusalem, Israel, dshveiky@gmail.com.

RESUMEN / SUMMARY:  - INTRODUCTION AND HYPOTHESIS: The objective was to determine the effect of uterine fibroid embolization (UFE) on lower urinary tract symptoms (LUTS) and quality of  life (QoL). METHODS: This prospective study included women with symptomatic fibroids and LUTS who underwent UFE between March 2008 and May 2010. Subjects underwent pre-procedural pelvic magnetic resonance imaging (MRI) and completed the Urogenital Distress Inventory (UDI-6), Incontinence Impact Questionnaire (IIQ-7), Prolapse and Incontinence Sexual Questionnaire (PISQ-12), Uterine Fibroid Symptom Quality of Life questionnaire (UFS-QoL), and a standardized 48-h  bladder diary at baseline and 3 months after the procedure. Patient Global Impression of Improvement (PGI-I) assessed post-procedural patient satisfaction.  The primary outcome was subjective improvement in LUTS at 3 months, as measured by a decrease in UDI-6 score. Univariate analysis, paired t test and a stepwise regression analysis were appropriately conducted. RESULTS: Fifty-seven patients underwent UFE and completed bladder diaries and questionnaires. At 3 months after UFE, patients reported a significant decrease in UDI-6, IIQ-7, and UFS-QoL, indicating an improvement in urinary symptoms and QoL. Bladder diaries showed a significant reduction in daytime and night-time voids. No difference was found in incontinence episodes. Uterine volume, dominant fibroid size, fibroid location, and MRI-confirmed bladder compression did not affect the difference in UDI-6 scores. In a stepwise regression model, BMI had a significant impact on the change in UDI-6 score, with a decrease of 1.18 points for each 1 unit increase in BMI. CONCLUSION: Uterine fibroid embolization significantly improves LUTS and urinary-related QoL. Obesity seems to attenuate this effect.

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[677]

TÍTULO / TITLE:  - Laparoscopic management of small-bowel intussusception in a 64-year-old female with ileoal lipomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastrointest Surg. 2012 Sep 27;4(9):220-2. doi: 10.4240/wjgs.v4.i9.220.

            ●● Enlace al texto completo (gratuito o de pago) 4240/wjgs.v4.i9.220

AUTORES / AUTHORS:  - Hou YC; Lee PC; Chang JJ; Lai PS

INSTITUCIÓN / INSTITUTION:  - Yi-Chung Hou, Po-Chu Lee, Jung-Jung Chang, Peng-Sheng Lai, Department of General  Surgery, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin County 64041, Taiwan, China.

RESUMEN / SUMMARY:  - A 64-year-old female patient presented with upper abdominal pain and vomiting. Ultrasonography showed a hyperechoic mass in the right lower abdomen and computed tomography showed a low-density mass with intestinal invagination. An emergency laparoscopic right-hemicolectomy was performed, and the resected specimen was found to contain three tumors, which were identified histopathologically as intestinal lipomas. Adult intussusception is relatively rare and difficult to be  diagnosed, since most symptoms of adult intussusception are nonspecific. We report our clinical experience of the diagnosis and emergent laparoscopic surgery for an adult patient with intussusception.

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[678]

TÍTULO / TITLE:  - Signet-ring cell carcinoma mimicking gastric gastrointestinal stromal tumor confirmed by endoscopic ultrasound-guided trucut biopsy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Endosc. 2012 Nov;45(4):421-4. doi: 10.5946/ce.2012.45.4.421. Epub 2012 Nov 30.

            ●● Enlace al texto completo (gratuito o de pago) 5946/ce.2012.45.4.421

AUTORES / AUTHORS:  - Kim SH; Lee ST; Jeon BJ; Kim IH; Kim SW; Lee SO; Kim DG; Park HS

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, The Research Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Korea.

RESUMEN / SUMMARY:  - A submucosal gastric adenocarcinoma, especially the signet ring cell type, is rare. The histologic evaluation techniques for this lesion has not been established; however, histologic confirmation is very important for decision of treatment method. Here, we report a 57-year-old man with a 12-cm gastric submucosal signet ring cell type adenocarcinoma, diagnosed by an endoscopic ultrasound-guided Trucut biopsy and immunochemical studies. This case suggests that the endoscopic ultrasound-guided Trucut biopsy might be a useful diagnostic  method in cases of gastric adenocarcinoma with features of gastrointestinal stromal tumor.

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[679]

TÍTULO / TITLE:  - Leiomyomas requiring chest wall resection and reconstruction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gen Thorac Cardiovasc Surg. 2012 Dec 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11748-012-0196-y

AUTORES / AUTHORS:  - Kanlioglu Kuman N; Pabuscu E; Meteoglu I

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey, nilkanlioglu@gmail.com.

RESUMEN / SUMMARY:  - Leiomyomas of the chest wall are very rare in the literature; only nine cases have been reported. We present two cases: First case was a 32-year-old female. Two separate pleural tumors were detected and resection was performed. Local recurrence occurred after 1 year follow-up and required chest wall resection and  reconstruction. The second case is a 43-year-old male. A tumor was found in 7th rib’s cartilage at radiological examination, and chest wall resection and reconstruction was performed. Both cases were diagnosed as leiomyoma in pathological examination. Multiple leiomyomas of chest wall or leiomyoma in rib was not reported in literature previously. Clinical and radiological appearance of leiomyomas can be variable, and discordance can be seen between these and the  pathological diagnosis. Chest wall resection may be required for cure of the leiomyomas although they are rare and considered as benign.

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[680]

TÍTULO / TITLE:  - Endoscopy dissection of small stromal tumors emerged from the muscularis propria  in the upper gastrointestinal tract: Preliminary study.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Gastrointest Endosc. 2012 Dec 16;4(12):565-70. doi: 10.4253/wjge.v4.i12.565.

            ●● Enlace al texto completo (gratuito o de pago) 4253/wjge.v4.i12.565

AUTORES / AUTHORS:  - Huang ZG; Zhang XS; Huang SL; Yuan XG

INSTITUCIÓN / INSTITUTION:  - Zhi-Gang Huang, Xue-Song Zhang, Shi-Liang Huang, Xiao-Gang Yuan, Department of Gastroenterology, Lihuili Hospital of Ningbo Medical Center, Ningbo 315040, Zhejiang Province, China.

RESUMEN / SUMMARY:  - AIM: To investigate the feasibility and safety of the treatment of an upper gastrointestinal (GI) submucosal tumor with endoscopic submucosal dissection (ESD). METHODS: A total of 20 patients with esophageal and gastric submucosal tumors emerged from the muscular layer identified by endoscopic ultrasonography were collected from January 2009 to June 2010. Extramural or dumbbell-like lesions were excluded by an enhanced computerized tomography (CT) scan. All patients had intravenous anesthesia with propofol and then underwent the ESD procedure to resect these submucosal tumors. The incision was closed by clips as  much as possible to decrease complications, such as bleeding or perforation, after resection of the tumor. All the specimens were collected and evaluated by hematoxylin, eosin and immunohistochemical staining, with antibodies against CD117, CD34, desmin, alpha-smooth muscle actin and vimentin to identify the characteristics of the tumors. Fletch’s criteria was used to evaluate the risk of gastrointestinal stromal tumors (GISTs). All patients underwent a follow-up endoscopy at 3, 6 and 12 mo and CT scan at 6 and 12 mo. RESULTS: The study group  consisted of 5 men and 15 women aged 45-73 years, with a mean age of 60.2 years.  Three tumors were located in the esophagus, 9 in the gastric corpus, 4 in the gastric fundus, 3 lesions in the gastric antrum and 1 in the gastric angulus. Apart from the one case in the gastric angulus which was abandoned due to being deeply located in the serosa, 94.7% (18/19) achieved complete gross dissection by ESD with operation duration of 60.52 +/- 30.32 min. The average maximum diameter  of tumor was 14.8 +/- 7.6 mm, with a range of 6 to 30 mm, and another lesion was  ligated by an endoscopic ligator after most of the lesion was dissected. After pathological and immunohistochemical analysis, 12 tumors were identified as a GI  stromal tumor and 6 were leiomyoma. Mitotic count of all 12 GIST lesions was fewer than 5 per 50 HPF and all lesions were at very low (9/12, 75.0%) or low risk (3/12, 25.0%) according to Fletch’s criteria. Procedure complications mainly included perforation and GI bleeding; perforation occurred in 1 patient and conservative treatment succeeded by a suturing clip and no post-operative GI bleeding occurred. All patients were followed up for 6.5 +/- 1.8 mo (range, 3-12  mo) by endoscopy and abdominal CT. Local recurrence and metastasis did not occur  in any patient. CONCLUSION: ESD shows promise as a safe and feasible technique to resect esophageal and gastric submucosal tumors and the incidence of complications was very low. Clinical studies with more subjects and longer follow-up are needed to confirm its treatment value.

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[681]

TÍTULO / TITLE:  - High-grade myxofibrosarcoma presenting at the spermatic cord after radiotherapy for prostate cancer.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2012 Nov 28;2012. pii: bcr0320126082. doi: 10.1136/bcr-03-2012-6082.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-03-2012-6082

AUTORES / AUTHORS:  - Tearada H; Nagata M; Mugiya S; Ozono S

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Terada Clinic, Hamamatsu, Shizuoka, Japan. teragi@hama-med.ac.jp

RESUMEN / SUMMARY:  - A 72-year-old man with a history of prostate cancer presented 7 years postradiotherapy with a painless, egg-sized, rapidly growing nodule on the left groin at the radiation site. He underwent left high orchiectomy under a diagnosis of groin lymph node metastasis of prostate cancer. The tumour had penetrated deep into the internal inguinal ring and was resected as proximally as possible to the internal ring with a positive surgical margin. Macroscopically, the left testis was intact in the resected specimen. Immunohistochemical staining revealed that the tumour consisted of myxofibrosarcoma (MFS) with spindle cells; and was positive for vimentin, cytokeratin (AE1/AE3), MIB-1 and CD68, and negative for alpha-SMA, S-100, CD34 and myogenin. Thus, the tumour was diagnosed as high-grade MFS of the spermatic cord. Postoperative CT revealed a right renal tumour and adrenal tumour. Right radial nephrectomy was performed and the patient was doing  well at 10-month follow-up.

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[682]

TÍTULO / TITLE:  - Prostatic stromal sarcoma with neuroectodermal differentiation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Pathol. 2012 Dec 7;7:173. doi: 10.1186/1746-1596-7-173.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1746-1596-7-173

AUTORES / AUTHORS:  - Yamazaki H; Ohyama T; Tsuboi T; Taoka Y; Kohguchi D; Iguchi H; Ao T

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Medical center hospital, Kitasato Institute, Kitasato University, Saitama, Japan. powder1104@hotmail.com.

RESUMEN / SUMMARY:  - ABSTRACT: Prostatic stromal sarcoma is a fairly rare tumor that constitutes approximately 0.1-0.2% of all prostatic cancers. Detailed characteristics of the  tumor are still unclear due to its rarity.We describe a case of prostatic stromal sarcoma in a 63 year-old man who suffered from urinary obstructive symptoms. Palliative transuterine resection was performed and the preliminary histopathological diagnosis was neuroendocrine carcinoma. After chemotherapy, total pelvic exenteration was performed. Histopathologically, the tumor was composed of monotonously proliferating small to medium-sized round cells, which existed in compact islands with loose or dense fibrovascular networks. Immunohistochemically, the tumor cells were widely positive for vimentin, CD56, CD99 and focally positive for synaptophysin, CD10, progesterone receptor, desmin  and CD34, but negative for EMA, cytokeratin, estrogen receptor, S-100 and myoglobin. Most of the previously reported tumors exhibited positive stainability for CD10 and progesterone receptor. In addition to these markers, expressions of  CD56, CD99 and synaptophysin were characteristically detected in our case. To the best of our knowledge, we present the first case of prostatic stromal sarcoma with characteristic immunohistochemical staining properties. Although the biological characteristics of this rare tumor have not yet been elucidated, these findings suggest prostatic stromal sarcoma can potentially show neuroectodermal differentiation. VIRTUAL SLIDE: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7291874028051262.

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[683]

TÍTULO / TITLE:  - Curent concepts in pathology of soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):302-8. doi: 10.1007/s13193-012-0134-6. Epub 2012 Apr 3.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-012-0134-6

AUTORES / AUTHORS:  - Husain N; Verma N

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, 226010 India.

RESUMEN / SUMMARY:  - Soft tissue sarcomas (STS) constitute a heterogeneous category of soft tissue neoplasia composed mostly of uncommon tumors of diverse histology, different biology and varied outcomes. Substantial developments in immunohistochemistry (IHC), cytogenetics and molecular genetics of STS have caused a significant change in the classification and diagnosis of these tumors with a direct implication for clinical management and prognosis. In this review we discuss newer developments impacting diagnosis and prediction.

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[684]

TÍTULO / TITLE:  - An alternative technique for the management of phalangeal enchondromas with pathologic fractures.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Hand Surg Am. 2013 Jan;38(1):104-9. doi: 10.1016/j.jhsa.2012.08.045. Epub 2012  Nov 28.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jhsa.2012.08.045

AUTORES / AUTHORS:  - Lin SY; Huang PJ; Huang HT; Chen CH; Cheng YM; Fu YC

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital; and the Department of Orthopedics, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

RESUMEN / SUMMARY:  - PURPOSE: Enchondroma of the hand with a pathologic fracture is generally treated  by tumor curettage and bone grafting after the fracture has healed. However, delayed surgery postpones definitive diagnosis and prolongs the period of disability. We have treated pathologic fractures in a single stage through a modified lateral surgical approach with curettage of the tumor and stabilization  using injectable calcium sulfate cement. The aim of this study was to report the  outcomes of treatment with this material and the modified approach. METHODS: Between 2006 and 2010, we enrolled 8 patients with solitary hand enchondromas and pathologic fractures. The surgical procedure involved a lateral approach, an extended lateral cortical window, thorough tumor evacuation, and reconstruction of the bone defects using commercially available injectable calcium sulfate cement. We performed evaluations before surgery and in the postoperative follow-up series by radiographs and clinical assessments, including measurement of joint motion by goniometry and a visual analog pain scale. RESULTS: The average time of follow-up was 19 months (range, 12-36 mo). The pathologic fractures of all patients healed clinically and radiographically within 8 weeks after surgery, and the mean active motion arcs of the metacarpophalangeal joints  and proximal interphalangeal joints of the involved digit were 90 degrees and 94  degrees , respectively at 3-month follow-up. All patients returned to ordinary daily activities without obvious pain by 3 months postoperatively. We found no major complications, such as unacceptable alignment, nonunion, infection, or tumor recurrence, during follow-up. CONCLUSIONS: This study demonstrated the outcomes of early management of phalangeal enchondromas with pathologic fractures using a lateral approach and injectable calcium sulfate cement for reconstruction. This combined approach avoided the need for supplemental internal fixation, allowed early mobilization, and resulted in minimal joint stiffness. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

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[685]

TÍTULO / TITLE:  - Free Osteoarticular Metatarsal Transfer for Giant Cell Tumor of Metacarpal-a Surgical Technique.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Hand Microsurg. 2011 Dec;3(2):89-92. doi: 10.1007/s12593-011-0048-5. Epub 2011  Jul 23.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12593-011-0048-5

AUTORES / AUTHORS:  - Maini L; Cheema GS; Yuvarajan P; Gautam VK

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedics, Lok Nayak and associated Hospitals, Jawahar lal Nehru Marg, New Delhi, 110002 India.

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[686]

TÍTULO / TITLE:  - Foreign body reaction to a retained surgical sponge (gossypiboma) mimicking an implant associated sarcoma in a dog after a tibial plateau levelling osteotomy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Vet Comp Orthop Traumatol. 2012 Dec 13;26(2).

            ●● Enlace al texto completo (gratuito o de pago) 3415/VCOT-11-12-0188

AUTORES / AUTHORS:  - Corbin EE; Cavanaugh RP; Fick JL; McAbee KP; Powers B

INSTITUCIÓN / INSTITUTION:  - Dr. Erin E. Corbin, University of Minnesota, College of Veterinary Medicine, Veterinary Medical Center, 1365 Gortner Avenue, St. Paul, MN 55108, United States, Phone: +1 612 626 8387, Fax: +1 612 624 8779, E-mail: corbin.ee@gmail.com.

RESUMEN / SUMMARY:  - A dog was presented with the complaint of an acute onset left pelvic limb lameness three years after a right tibial plateau levelling osteotomy had been performed. Radiographs taken at the time of presentation showed signs that were consistent with a diagnosis of an implant associated sarcoma. At revision surgery a retained surgical sponge was identified, leading to a diagnosis of a gossypiboma. This is the first reported case of a gossypiboma as a complication of a tibial plateau levelling osteotomy surgery.

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[687]

TÍTULO / TITLE:  - Superior vena cava syndrome as a rare complication to lipomatous atrial septal hypertrophy (LASH).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Heart J Cardiovasc Imaging. 2013 Jan 14.

            ●● Enlace al texto completo (gratuito o de pago) 1093/ehjci/jes324

AUTORES / AUTHORS:  - Soholm H; Iversen K; Olsen PS; Andersen CB; Hassager C

INSTITUCIÓN / INSTITUTION:  - Department of Cardiology 2142, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen O, Denmark.

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[688]

TÍTULO / TITLE:  - Primary epithelioid sarcoma of the scalp complicated by humoral hypercalcemia of  malignancy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eplasty. 2012;12:ic18. Epub 2012 Dec 10.

AUTORES / AUTHORS:  - Tocco I; Bassetto F; Vindigni V

INSTITUCIÓN / INSTITUTION:  - Clinic of Plastic Surgery, University of Padova, Italy.

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[689]

TÍTULO / TITLE:  - Endoscopic-assisted resection of peripheral osteoma using piezosurgery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan;115(1):e16-20. doi: 10.1016/j.oooo.2011.09.032. Epub 2012 May 10.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.oooo.2011.09.032

AUTORES / AUTHORS:  - Ochiai S; Kuroyanagi N; Sakuma H; Sakuma H; Miyachi H; Shimozato K

INSTITUCIÓN / INSTITUTION:  - Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Aichi, Japan. ochiai@dpc.aichi-gakuin.ac.jp

RESUMEN / SUMMARY:  - Endoscopic-assisted surgery has gained widespread popularity as a minimally invasive procedure, particularly in the field of maxillofacial surgery. Because the surgical field around the mandibular angle is extremely narrow, the surrounding tissues may get caught in sharp rotary cutting instruments. In piezosurgery, bone tissues are selectively cut. This technique has various applications because minimal damage is caused by the rotary cutting instruments when they briefly come in contact with soft tissues. We report the case of a 33-year-old man who underwent resection of an osteoma in the region of the mandibular angle region via an intraoral approach. During surgery, the complete surgical field was within the view of the endoscope, thereby enabling the surgeon to easily resection the osteoma with the piezosurgery device. Considering that piezosurgery limits the extent of surgical invasion, this is an excellent low-risk technique that can be used in the field of maxillofacial surgery.

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[690]

TÍTULO / TITLE:  - Percutaneous cardiopulmonary support for pulmonary thromboembolism caused by large uterine leiomyomata.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Taiwan J Obstet Gynecol. 2012 Dec;51(4):639-42. doi: 10.1016/j.tjog.2012.09.023.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.tjog.2012.09.023

AUTORES / AUTHORS:  - Kurakazu M; Ueda T; Matsuo K; Ishikura H; Kumagai N; Yoshizato T; Miyamoto S

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Iizuka Hospital, Iizuka, Japan; Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

RESUMEN / SUMMARY:  - OBJECTIVE: Acute pulmonary thromboembolism (PTE) is a common illness that causes  death and disability. Deep vein thrombosis (DVT) is often found in patients with  a large myomatous uterus, and can occasionally result in acute PTE. Here, we describe the achievement of a favorable outcome in a case of acute PTE. CASE REPORT: The patient presented with acute PTE caused by a large uterine leiomyoma, without DVT of the lower extremities. Percutaneous cardiopulmonary support (PCPS) was used as an adjunct to thrombolytic therapy to treat the right ventricular thrombus with acute PTE. According to emergency practice, PCPS was initiated, and the patient was successfully treated with thrombolytic and anticoagulant therapy  associated with total abdominal hysterectomy. CONCLUSIONS: This case suggests that PCPS can lead to favorable clinical outcomes in patients with large uterine  leiomyomata and severe PTE.

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[691]

TÍTULO / TITLE:  - Traumatic fibroma of tongue.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 24;2013. pii: bcr2012008220. doi: 10.1136/bcr-2012-008220.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-008220

AUTORES / AUTHORS:  - Rathva VJ

INSTITUCIÓN / INSTITUTION:  - Department of Periodontics, KM Shah Dental College and Hospital, Baroda, Gujarat, India.

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[692]

TÍTULO / TITLE:  - Immediate reconstruction of the chest wall by latissimus dorsi and vertical rectus abdominis musculocutaneous flaps after radical mastectomy for a huge pleomorphic liposarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Plast Surg Hand Surg. 2013 Jan 28.

            ●● Enlace al texto completo (gratuito o de pago) 3109/2000656X.2012.748309

AUTORES / AUTHORS:  - Shoham Y; Koretz M; Kachko L; Silberstien E; Krieger Y; Bogdanov-Berezovsky A

INSTITUCIÓN / INSTITUTION:  - Plastic and Reconstructive Surgery Department.

RESUMEN / SUMMARY:  - Abstract We describe a 53-year-old woman who had a huge pleomorphic liposarcoma of the left breast. She had a left Halstead mastectomy, which left a huge defect  in the chest wall. We did an immediate reconstruction of the chest wall with combined latissimuss dorsi musculocutaneous (for the upper half of the defect) and vertical rectus abdominis musculocutaneous flaps (for the lower half of the defect). She then had radiotherapy and chemotherapy during which time the flaps remained viable and provided satisfactory coverage for the irradiated area. Unfortunately four months later she was diagnosed with spinal cord and lung metastases and died seven months after the operation.

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[693]

TÍTULO / TITLE:  - Neoadjuvant imatinib for borderline resectable GIST.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Natl Compr Canc Netw. 2012 Dec 1;10(12):1477-82; quiz 1482.

AUTORES / AUTHORS:  - Koontz MZ; Visser BM; Kunz PL

INSTITUCIÓN / INSTITUTION:  - Stanford University School of Medicine, California, USA.

RESUMEN / SUMMARY:  - A 36-year-old woman presented to the emergency department with black stools and syncope. Her hemoglobin was 7.0 and her red blood cells were microcytic. Upper endoscopy did not identify a clear source of bleeding, but a bulge in the third portion of the duodenum was noted. A CT scan showed a large extraintestinal mass, and follow-up esophagogastroduodenoscopy/endoscopic ultrasound with biopsy revealed a spindle cell neoplasm, consistent with gastrointestinal stromal tumor  (GIST). Because of the size of the lesion and association with the superior mesenteric vein and common bile duct, she was referred to medical oncology for consideration of neoadjuvant imatinib. Neoadjuvant tyrosine kinase inhibitor therapy for GISTs is emerging as a viable treatment strategy for borderline resectable tumors, although the dose, duration, and optimal imaging modalities have not been clearly established. Recent pathologic and radiographic data have provided insight into the mechanism and kinetics of this approach. This case report presents a patient for whom surgery was facilitated using neoadjuvant imatinib.

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[694]

TÍTULO / TITLE:  - Robotic gastric resection of large gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg. 2013 Jan 12. pii: S1743-9191(13)00012-5. doi: 10.1016/j.ijsu.2013.01.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijsu.2013.01.002

AUTORES / AUTHORS:  - Desiderio J; Trastulli S; Cirocchi R; Boselli C; Noya G; Parisi A; Cavaliere D

INSTITUCIÓN / INSTITUTION:  - Department of Digestive Surgery and Liver Unit, St. Maria Hospital, Terni, Italy. Electronic address: djdesi85@hotmail.it.

RESUMEN / SUMMARY:  - BACKGROUND: The stomach is the most common site for gastrointestinal stromal tumors (GIST) development. Surgical treatment consists of excision of the entire  neoplastic mass, with sufficient surgical margins within healthy tissue. This can be achieved with different techniques ranging from wedge resections, typical gastric resections, right up to total gastrectomy. There aren’t clear guidelines  for the use of minimally invasive approach. MATERIALS AND METHODS: From January 2011 to April 2012, 5 patients with presumed preoperative diagnosis of GIST were  treated by robotic surgery at the Unit of Surgery and Advanced Oncologic Therapies, Forli Hospital, Forli, Italy. We report operative techniques, perioperative outcomes and follow-up. RESULTS: Lesions were localized at anterior wall of gastric antrum (N = 2) and near pyloric area (N = 3). Mean tumor size was 5 cm (range 4-7 cm). Surgical procedures were 5 distal gastrectomy. None intervention was converted to open surgery and there weren’t major intraoperative complications. Median operative time was 240 min (range 210-300 min) and mean intraoperative blood loss was 96 ml (80-120 ml). All lesions had microscopically  negative resection margins. Median follow-up was 13.5 months (range 12-15 months) with a disease-free survival rate of 100%. CONCLUSIONS: Surgical robotic approach for large GISTs is feasibility and new evidences are needed to clarify the effective role of different surgical strategies.

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[695]

TÍTULO / TITLE:  - Autophagy is involved in endogenous and NVP-AUY922-induced KIT degradation in gastrointestinal stromal tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Autophagy. 2013 Feb 1;9(2):220-33. doi: 10.4161/auto.22802. Epub 2012 Nov 29.

            ●● Enlace al texto completo (gratuito o de pago) 4161/auto.22802

AUTORES / AUTHORS:  - Hsueh YS; Yen CC; Shih NY; Chiang NJ; Li CF; Chen LT

INSTITUCIÓN / INSTITUTION:  - Institute of Clinical Pharmacy and Pharmaceutical Science; National Cheng Kung University; Tainan, Taiwan; National Institute of Cancer Research; National Health Research Institutes; Tainan, Taiwan.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumor (GIST) is a prototype of mutant KIT oncogene-driven tumor. Prolonged tyrosine kinase inhibitor (TKI) treatment may result in a resistant phenotype through acquired secondary KIT mutation. Heat shock protein 90 (HSP90AA1) is a chaperone protein responsible for protein maturation and stability, and KIT is a known client protein of HSP90AA1. Inhibition of HSP90AA1 has been shown to destabilize KIT protein by enhancing its degradation via the proteasome-dependent pathway. In this study, we demonstrated  that NVP-AUY922 (AUY922), a new class of HSP90AA1 inhibitor, is effective in inhibiting the growth of GIST cells expressing mutant KIT protein, the imatinib-sensitive GIST882 and imatinib-resistant GIST48 cells. The growth inhibition was accompanied with a sustained reduction of both total and phosphorylated KIT proteins and the induction of apoptosis in both cell lines. Surprisingly, AUY922-induced KIT reduction could be partially reversed by pharmacological inhibition of either autophagy or proteasome degradation pathway. The blockade of autophagy alone led to the accumulation of the KIT protein, highlighting the role of autophagy in endogenous KIT turnover. The involvement of autophagy in endogenous and AUY922-induced KIT protein turnover was further confirmed by the colocalization of KIT with MAP1LC3B-, acridine orange- or SQSTM1-labeled autophagosome, and by the accumulation of KIT in GIST cells by silencing either BECN1 or ATG5 to disrupt autophagosome activity. Therefore, the  results not only highlight the potential application of AUY922 for the treatment  of KIT-expressing GISTs, but also provide the first evidence for the involvement  of autophagy in endogenous and HSP90AA1 inhibitor-induced KIT degradation.

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[696]

TÍTULO / TITLE:  - Fibromatosis Arising in Association with Neuromuscular Hamartoma of the Mandible.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Head Neck Pathol. 2013 Jan 12.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12105-012-0418-8

AUTORES / AUTHORS:  - Taher LY; Saleem M; Velagapudi S; Dababo A

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Taibah University, Al-Madina, Saudi Arabia, leena.taher@gmail.com.

RESUMEN / SUMMARY:  - Aggressive fibromatosis is a benign but locally-aggressive tumor, which most often affects the muscles of the shoulder, the pelvic girdle, and the thigh. It usually affects adolescents and young adults. Desmoplastic fibroma, considered the bone counterpart of soft tissue fibromatosis, is a rare tumor that usually affects the metaphyseal or diaphyseal portions of long bones or, less commonly, the jaw. Neuromuscular hamartoma, a rare developmental lesion composed of mature  elements of both striated muscle and nerve, is usually diagnosed in infants and children and affects large nerve trunks. Rarely, it can affect the head and neck  region. Occasional cases showing an association between aggressive fibromatosis and neuromuscular hamartoma have been reported in the literature. Here we present a unique case of an adult patient with desmoplastic fibroma of the mandible in association with neuromuscular hamartoma.

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[697]

TÍTULO / TITLE:  - Chondromyxoid fibroma of calcaneus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Foot Ankle Surg. 2013 Mar;19(1):48-52. doi: 10.1016/j.fas.2012.10.003. Epub 2012  Nov 7.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.fas.2012.10.003

AUTORES / AUTHORS:  - Jamshidi K; Mazhar FN; Yahyazadeh H

INSTITUCIÓN / INSTITUTION:  - ShafaYahyaian Rehabilitation Center, Tehran University of Medical Sciences, Tehran, Iran.

RESUMEN / SUMMARY:  - BACKGROUND: Chondromyxoid fibroma is a rare benign primary bone tumor composed of immature myxoid mesenchymal and cartilaginous tissue. Its occurrence in calcaneus is very rare and few cases of calcaneal involvement have been reported in literature. We report five cases of CMF in calcaneus. METHODS: Five cases, with the final diagnosis of chondromyxoid fibroma of the calcaneal bone are included in this report. Preoperative tumor workup was performed for our patients. We reviewed and recorded demographic data and the sign and symptoms of patients at presentation to our center. Mode of treatments, postoperative complications and recurrence were also studied. Curettage, high speed burring and bone grafting was performed in 4 of our patients and in the remaining case we only carried out curettage and burring. RESULTS: Of the five patients, 3 were male and 2 were female. The mean age at presentation was 21. Two of our cases had previous surgery in other centers and had been referred to our clinic because of recurrence. The chief complaint in all of our patients was heel pain. The mean follow up period was 25.2 months. All of our patients had a delay in the diagnosis of tumor. We did not have any recurrence in our patients during follow  up period. CONCLUSIONS: This case series shows that chondromyxoid fibroma is not  necessarily as exceedingly rare as generally reported in the current literature.  This tumor should be considered in the differential diagnosis in patients with ankle and heel pain.

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[698]

TÍTULO / TITLE:  - Trends in Kaposi’s Sarcoma in Miami Beach from 1987 to 2007.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - ISRN Oncol. 2012;2012:642106. doi: 10.5402/2012/642106. Epub 2012 Dec 25.

            ●● Enlace al texto completo (gratuito o de pago) 5402/2012/642106

AUTORES / AUTHORS:  - Zeichner SB; Ruiz AL; Suciu GP; Zeichner RL; Rodriguez E

INSTITUCIÓN / INSTITUTION:  - Department of Internal Medicine, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA.

RESUMEN / SUMMARY:  - Purpose. Kaposi’s sarcoma (KS) is a rare low-grade vascular tumor associated with the human herpes virus 8. By analyzing the epidemiology, staging, and treatment of KS, we hoped to improve the quality of care at our institution. Methods. Review of the Mount Sinai Medical Center tumor registry database in Miami Beach,  FL, USA, identified 143 cases of KS between January 1, 1987 and December 31, 2007. Results. The majority of patients were non-Hispanic whites, non smoking males diagnosed between 1987 and 1996. Most of the patients were HIV positive, with an equal percentage diagnosed with local or distant disease. Most patients received no chemotherapy or radiation. There were no significant differences in patient survival based on sex, HIV status, or radiation received. There was a trend toward improved survival among older patients who smoked, received no chemotherapy, and had localized stage at diagnosis. Multivariate analysis revealed that non-Hispanic whites had a significant worse survival than Hispanic  whites (HR = 0.55, 95% CI (0.33, 0.90), P = 0.02). Patients diagnosed between 1987 and 1996 had a worse survival than those between 1997 and 2007 (HR = 0.33 (95% CI 0.19, 0.55), P < 0.0001). Conclusion. This large retrospective study provides further insight into KS. Ethnicity and date of diagnosis are important predictors of long-term survival.

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[699]

TÍTULO / TITLE:  - Osteosarcoma of mandible.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Diagn Res. 2012 Nov;6(9):1597-9. doi: 10.7860/JCDR/2012/3922.2574.

            ●● Enlace al texto completo (gratuito o de pago) 7860/JCDR/2012/3922.2574

AUTORES / AUTHORS:  - Kalburge JV; Sahuji SK; Kalburge V; Kini Y

INSTITUCIÓN / INSTITUTION:  - Professor, Department of Oral & Maxillofacial Pathology, Rural Dental College, Pravara Institute of Medical Sciences , Loni, India.

RESUMEN / SUMMARY:  - Osteosarcomas are malignant neoplasms of the bone which commonly affect the long  bones. The involvement of the jaws are rarely noticed. These neoplasms often shows a typical clinical behaviour as well as varied radiological appearances. Similarly, their histological growth pattern can be quite diverse. Confirmation of the final diagnosis of an osteosarcoma often requires a histopathological examination of the multiple biopsy specimens and vigorous discussion amongst the  experts. All these clinical features, radiographic appearances and histological diagnostic difficulties were encountered in a case of osteosarcoma of the mandible in a 29-year old female.

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[700]

TÍTULO / TITLE:  - Chondrosarcoma of the spinous process: a rare presentation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Asian Spine J. 2012 Dec;6(4):279-83. doi: 10.4184/asj.2012.6.4.279. Epub 2012 Dec 14.

            ●● Enlace al texto completo (gratuito o de pago) 4184/asj.2012.6.4.279

AUTORES / AUTHORS:  - Arockiaraj J; Venkatesh K; Amritanand R; Sundararaj GD; Nachimuthu G

INSTITUCIÓN / INSTITUTION:  - Spinal Disorder Surgery Unit, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

RESUMEN / SUMMARY:  - Chondrosarcomas are malignant cartilage forming tumours. They form the second most common primary malignant tumour involving the vertebral axis. We present a rare presentation of a secondary chondrosarcoma from the spinous process of lumbar vertebra and discussed its management. The main emphasis is on the rare presentation and the need for awareness and suspicion of the pathology.

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[701]

TÍTULO / TITLE:  - ESMO: regorafenib improved PFS for GIST in post-imatinib/sunitinib setting.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncology (Williston Park). 2012 Nov;26(11):1072.

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[702]

TÍTULO / TITLE:  - Cysticercus of the Breast which Mimicked a Fibroadenoma: A Rare Presentation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Diagn Res. 2012 Nov;6(9):1555-6. doi: 10.7860/JCDR/2012/4184.2559.

            ●● Enlace al texto completo (gratuito o de pago) 7860/JCDR/2012/4184.2559

AUTORES / AUTHORS:  - T M K; D M; V R M

INSTITUCIÓN / INSTITUTION:  - Associate Professor, Department of Pathology, Melmaruvathur Adhiparasakthi Medical College, Melmaruvathur, Tamil Nadu, India - 603319.

RESUMEN / SUMMARY:  - Human cysticercosis is an infection which is caused by the larvae of the pork tapeworm, Taenia solium. They can affect any part of the body, the most common sites being the muscle, the CNS and the subcutaneous tissues. In this report , we are presenting the case of a 32-year old woman who came with a history of a painless, freely mobile lump in the left breast. A clinical diagnosis of a fibroadenoma was made and an excision biopsy was done, which revealed the presence of cysticercus lavae, along with a foreign body giant cell reaction. A diagnosis of cysticercus at the atypical sites is rare and it depends mainly on the histopathological examination. Although it is rare, cysticercus should be considered as a differential diagnosis for a mass in the breast and in the areas  of a greater prevalence.

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[703]

TÍTULO / TITLE:  - Intranodal palisaded myofibroblastoma presenting as lymphadenopathy of the groin.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 11;2013. pii: bcr2012006374. doi: 10.1136/bcr-2012-006374.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-006374

AUTORES / AUTHORS:  - Loizou P; Evgeniou E; Scott-Young N; Orlando A

INSTITUCIÓN / INSTITUTION:  - Department of Plastic Surgery, Frenchay Hospital, Bristol, UK.

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[704]

TÍTULO / TITLE:  - Ileoileal intussusception secondary to an ileal fibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Gastroenterol. 2012 Sep;6(3):734-40. doi: 10.1159/000345806. Epub 2012 Sep 22.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000345806

AUTORES / AUTHORS:  - Chelimilla H; Ihimoyan A; Carvajal S; Bhavna B

INSTITUCIÓN / INSTITUTION:  - Division of Gastroenterology, Bronx-Lebanon Hospital Center, Bronx, New York, N.Y., USA.

RESUMEN / SUMMARY:  - Intussusception is defined as the telescoping of a segment of the gastrointestinal tract (intussusceptum) into an immediately adjacent distal bowel (intussuscipiens). Intussusception is a relatively rare cause of intestinal obstruction in adults. Unlike in children, a lead point is present in 90% of adult cases. The most common causes of small bowel intussusception are benign, usually hamartomas, lipomas, inflammatory polyps, adenomas and leiomyomas, in contrast to the large intestine where malignant tumors, usually adenocarcinomas,  are more common. The clinical presentation of adult intussusception is non-specific with variable manifestations, predominantly those of intestinal obstruction, often making the diagnosis a challenge. The onset of symptoms may be acute, intermittent or chronic. We present a rare case of an ileal fibroma presenting with intussusception. A 43-year-old woman presented to our outpatient  clinic with a history of recurrent abdominal pain. The clinical presentation and  CT scan findings led to the diagnosis of ileoileal intussusception. Subsequently  she underwent laparotomy which revealed an ileal fibroma as the lead point of the intussusception. Surgical exploration remains essential for diagnosis and treatment since in the majority of cases a pathologic lead point is identified. Ileal fibroma is an uncommon benign neoplasm of the small bowel and must be considered in the differential diagnosis for small bowel intussusception.

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[705]

TÍTULO / TITLE:  - Vulvar lactating adenoma associated to a fibroadenoma: common neoplasms in an uncommon site.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pan Afr Med J. 2012;13:47. Epub 2012 Nov 13.

AUTORES / AUTHORS:  - Dhaoui A; Nfoussi H; Kchir N; Haouet S

INSTITUCIÓN / INSTITUTION:  - Pathology Department, La Rabta Hospital, Tunis El Manar University, Tunis, Tunisia.

RESUMEN / SUMMARY:  - Ectopic breast tissue is defined as glands located outside of the breast. Ectopic breast tissue should be excised because it may develop benign (fibroadenoma) or malignant pathologic processes. Less than forty cases of fibroadenomas have been  reported in the literature. Although lactation changes can occur, lactating adenoma in the vulva are extremely rare. Only four cases have been reported. We report a case of a young woman who presented with vulvar mass during her lactation. The mass was excised, and histology confirmed vulvar lactating adenoma associated with fibroadenoma. This is the first case of vulvar heterotopic breast lesion associating lactating adenoma and fibroadenoma.

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[706]

TÍTULO / TITLE:  - Osteoblastoma of the rib: A rare benign tumor with an unusual location.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Case Rep. 2013;4(2):146-8. doi: 10.1016/j.ijscr.2012.09.016. Epub 2012 Nov 21.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2012.09.016

AUTORES / AUTHORS:  - Katsenos S; Archondakis S; Sakellaridis T

INSTITUCIÓN / INSTITUTION:  - Department of Pneumonology, General Army Hospital of Athens, Athens, Greece. Electronic address: skatsenos@yahoo.gr.

RESUMEN / SUMMARY:  - INTRODUCTION: Osteoblastoma is a rare benign bone tumor commonly located at spine and long bones. However, rib involvement has been reported less frequently. PRESENTATION OF CASE: In this report, we describe a young adult male presenting with left posterolateral chest wall pain. Chest computed tomography showed a calcified tumor in the left third posterior segment of the rib. Radical mass resection was performed and histopathology confirmed a benign osteoblastoma. At last follow-up, 10 months postoperatively, the patient has eventually relieved of the unbearable chest pain. Imaging evaluation revealed no evidence of recurrent tumor. DISCUSSION: Osteoblastoma is an uncommon primary bone tumor accounting for only 1% of all bone tumors. Ribs are involved in less than 5% of patients. The disease has usually good prognosis with a tendency for local destruction and recurrence. CONCLUSION: Radical surgery remains the treatment of choice to prevent recurrences and to provide a definite diagnosis differentiating it from osteoblastoma-like osteosarcoma.

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[707]

TÍTULO / TITLE:  - Photoletter to the editor: Fibrous histiocytoma developing at the site of tuberculin skin test.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Dermatol Case Rep. 2012 Dec 31;6(4):130-1. doi: 10.3315/jdcr.2012.1123.

            ●● Enlace al texto completo (gratuito o de pago) 3315/jdcr.2012.1123

AUTORES / AUTHORS:  - Nomura E; Yamamoto T

INSTITUCIÓN / INSTITUTION:  - Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

RESUMEN / SUMMARY:  - Benign fibrous histiocytomas of the skin sometimes extend into the deeper dermis  with higher cellularity and show more aggressive clinical courses in comparison with typical dermatofibromas. They may occur either as a true neoplasm or in a reactive process. We describe a case of fibrous histiocytoma which was triggered  by tuberculin skin test.

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[708]

TÍTULO / TITLE:  - GI Synovial Sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Transl Gastroenterol. 2012 Apr 19;3:e11. doi: 10.1038/ctg.2012.6.

            ●● Enlace al texto completo (gratuito o de pago) 1038/ctg.2012.6

AUTORES / AUTHORS:  - Sinniah RP; Roche E; Cameron D

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology, The Townsville Hospital, Queensland, Australia.

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[709]

TÍTULO / TITLE:  - Surface characteristics and osteoblastic cell response of alkali-and heat-treated titanium-8tantalum-3niobium alloy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Periodontal Implant Sci. 2012 Dec;42(6):248-55. doi: 10.5051/jpis.2012.42.6.248. Epub 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 5051/jpis.2012.42.6.248

AUTORES / AUTHORS:  - Lee BA; Kang CH; Vang MS; Jung YS; Piao XH; Kim OS; Chung HJ; Kim YJ

INSTITUCIÓN / INSTITUTION:  - Department of Periodontology, Dental Research Institute, Chonnam National University School of Dentistry, Gwangju, Korea.

RESUMEN / SUMMARY:  - PURPOSE: The aim of the present study was to evaluate the biological response of  alkali- and heat-treated titanium-8tantalum-3niobium surfaces by cell proliferation and alkaline phosphatase (ALP) activity analysis. METHODS: Commercial pure titanium (group cp-Ti) and alkali- and heat-treated titanium-8tantalum-3niobium (group AHT) disks were prepared. The surface properties were evaluated using scanning electron microscopy, energy dispersed spectroscopy and X-ray photoelectron spectroscopy (XPS). The surface roughness was evaluated by atomic force microscopy and a profilometer. The contact angle and surface energy were also analyzed. The biological response of fetal rat calvarial cells on group AHT was assessed by cell proliferation and ALP activity. RESULTS: Group AHT showed a flake-like morphology microprofile and dense structure. XPS analysis of group AHT showed an increased amount of oxygen in the  basic hydroxyl residue of titanium hydroxide groups compared with group cp-Ti. The surface roughness (Ra) measured by a profilometer showed no significant difference (P>0.05). Group AHT showed a lower contact angle and higher surface energy than group cp-Ti. Cell proliferation on group AHT surfaces was significantly higher than on group cp-Ti surfaces (P<0.05). In comparison to group cp-Ti, group AHT enhanced ALP activity (P<0.05). CONCLUSIONS: These results suggest that group AHT stimulates osteoblast differentiation.

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[710]

TÍTULO / TITLE:  - Vascular leiomyoma of the lung arising from pulmonary artery.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Clin Exp Pathol. 2013;6(1):97-9. Epub 2012 Nov 20.

AUTORES / AUTHORS:  - Terada T

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Shizuoka City Shimizu Hospital Shizuoka, Japan. piyo0111jp@yahoo.co.jp

RESUMEN / SUMMARY:  - Leiomyoma of the lung is extremely rare. The entity is not described in WHO blue  book. Less than 100 cases of leiomyoma of the lung have been reported in the literature. However, vascular leiomyoma has not been reported in the literature,  to the author’s best knowledge. Herein reported is the first case of vascular leiomyoma of the lung arising from smooth muscles of the pulmonary artery. A 62-year-old woman (non-smoker) was found to have a small tumor in the upper lobe  in the right lung in routine check. Imaging modalities including CT demonstrated  no metastatic lesions. Although clinical cytology and biopsy revealed no malignant cell, right upper lobectomy was performed under the clinical diagnosis  of lung carcinoma. Grossly, a white tumor of 1 x 0.8 cm was recognized in the lung. Microscopically, the tumor was connected to the pulmonary arteries. The tumor was composed of mature smooth muscles. Small pulmonary arteries are embedded in the tumor. No lymphatics were seen. Immunohistochemically, the tumor  cells were poisitive for alpha-smooth muscle actin, vimentin and Ki-67 (labeling  2%). However, they were negative for cytokeratin (CK) AE1/3, CK CAM5.2, desmin, S100 protein, p53, CD34, KIT, HMB45, estrogen receptor, progesterone receptor, and myoglobin. A pathological diagnosis of primary vascular leiomyoma arising from the smooth muscle of pulmonary artery was made. The patient is now free from tumor, and is now alive 10 year after the operation.

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[711]

TÍTULO / TITLE:  - Primary fibrosarcoma of kidney.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Iran J Kidney Dis. 2013 Jan;7(1):7-8.

AUTORES / AUTHORS:  - Monfared A

INSTITUCIÓN / INSTITUTION:  - Urology Research Center and Depatment of Nephrology, Guilan University of Medical Sciences, Rasht, Iran. drmonfared2009@gmail.com.

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[712]

TÍTULO / TITLE:  - Aggressive angiomyxoma: a small palpable vulvar lesion with a huge mass in the pelvis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Low Genit Tract Dis. 2013 Jan;17(1):75-8. doi: 10.1097/LGT.0b013e3182507df8.

            ●● Enlace al texto completo (gratuito o de pago) 1097/LGT.0b013e3182507df8

AUTORES / AUTHORS:  - Huang CC; Sheu CY; Chen TY; Yang YC

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan.

RESUMEN / SUMMARY:  - Aggressive angiomyxoma (AAM) is a rare soft tissue tumor typically in the pelvis  and perineum in women of reproductive age, which is easily misdiagnosed. We describe a woman with vulvar AAM, initially mismanaged as a Bartholin cyst. However, a huge pelvic mass is noted on the following imaging studies. The characteristics of AAM on computed tomography and magnetic resonance imaging have been specified in the literature, but we further point out the potential value of sonography in diagnosing AAM. Besides, excisional biopsy may cause tumor bleeding in a case of AAM.

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[713]

TÍTULO / TITLE:  - Giant cell tumor of the tendon sheath.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Hand Surg Am. 2013 Jan;38(1):154-7. doi: 10.1016/j.jhsa.2012.11.001.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.jhsa.2012.11.001

AUTORES / AUTHORS:  - Lanzinger WD; Bindra R

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedics, Akron General Medical Center, Akron, OH; and the Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, IL. Electronic address: wlanzinger14@gmail.com.

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[714]

TÍTULO / TITLE:  - Fronto-orbital osteoma. Answer to the e-quid “Unilateral exophthalmos in a 30-year-old man”.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Interv Imaging. 2013 Jan;94(1):119-22. doi: 10.1016/j.diii.2012.05.005.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.diii.2012.05.005

AUTORES / AUTHORS:  - Haddar S; Neji H; Dabbeche C; Guermazi Y; Fakhfakh K; Ben Mahfoudh K; Mnif Z; Mnif J

INSTITUCIÓN / INSTITUTION:  - Department of Radiology and Medical Imaging, Habib Bourguiba University Hospital  Center, Sfax, Tunisia. Electronic address: sondeshaddar@yahoo.fr.

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[715]

TÍTULO / TITLE:  - Inpatient burden of gastrointestinal stromal tumors in the United States.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gastrointest Oncol. 2012 Dec;3(4):335-41. doi: 10.3978/j.issn.2078-6891.2012.037.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2078-6891.2012.037

AUTORES / AUTHORS:  - Datar M; Khanna R

INSTITUCIÓN / INSTITUTION:  - Department of Pharmacy Administration, School of Pharmacy, The University of Mississippi, University, MS 38677-1848, USA.

RESUMEN / SUMMARY:  - The purpose of this study was to determine the inpatient burden among patients with gastrointestinal stromal tumors (GISTs). The study assessed hospitalization  rates of GISTs and compared hospital characteristics among patients with and without GISTs. Further, predictors of total charges and mortality among patients  with GISTs were identified.The 2009 Healthcare Utilization Project Nationwide Inpatient Sample (HCUP-NIS) database was analyzed for this study. Inpatient burden among patients with GISTs (cases) was compared to that among patients without GISTs or any diagnosis of cancer (controls). Linear regression was used to determine the factors predicting total charges, and logistic regression was used to determine predictors of mortality. Analyses were performed using SAS version 9.2.In 2009, there were 14,562 hospitalizations among patients with GISTs at a rate of 44/100,000 admissions. Hospitalization rates among patients with GISTs varied by patient-, hospital-, and discharge-level characteristics. Patients with GISTs had longer length of stay (LOS), total charges, and mortality rate as compared to the control group. Total charges for hospitalizations among patients with GISTs varied by household income, hospital location and region, LOS, and number of diagnoses on record, respectively. When examining the predictors of mortality, household income, hospital region, and number of diagnoses on record emerged significant.By examining the inpatient burden among patients with GISTs, this study fills a critical gap in this area of research. Future studies could merge medical services claims data with cancer registry data to study in-depth the humanistic and economic burden associated with GISTs.

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[716]

TÍTULO / TITLE:  - Epithelioid inflammatory myofibroblastic sarcoma arising in the pleural cavity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Gen Thorac Cardiovasc Surg. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11748-013-0204-x

AUTORES / AUTHORS:  - Kozu Y; Isaka M; Ohde Y; Takeuchi K; Nakajima T

INSTITUCIÓN / INSTITUTION:  - Division of Thoracic Surgery, Shizuoka Cancer Center, Shimonagakubo 1007, Nagaizumi, Shizuoka, 411-8777, Japan, y.kozu@scchr.jp.

RESUMEN / SUMMARY:  - A 57-year-old Japanese man presented with massive right pleural effusion, and a huge tumor arising in the pleural cavity was detected by chest computed tomography. A thoracoscopic tumor biopsy revealed that the tumor protruded extensively into the pleural cavity, and its gross appearance was cystic and glossy. Microscopically, the tumor cells were rounded and epithelioid in shape. Prominent and abundant myxoid stroma was also present together with an inflammatory infiltrate, and the tumor was anaplastic lymphoma kinase (ALK)-immunopositive. Fluorescence in situ hybridization revealed that the Ran-binding protein 2-ALK fusion gene was present. Taken together, these findings supported the diagnosis of epithelioid inflammatory myofibroblastic sarcoma (EIMS), which is a variant of an inflammatory myofibrobrastic tumor. This is the  first reported case of an EIMS arising in the pleural cavity.

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[717]

TÍTULO / TITLE:  - Monophasic epithelial synovial sarcoma accompanied by an inverted papilloma in the sphenoid sinus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Report Med. 2012;2012:379720. doi: 10.1155/2012/379720. Epub 2012 Dec 4.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/379720

AUTORES / AUTHORS:  - Jiang X; Huang Q; Tang J; Hoffman MR

INSTITUCIÓN / INSTITUTION:  - Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Zhejiang, Hangzhou 310016, China.

RESUMEN / SUMMARY:  - A 58-year-old man presented with a six-month history of intermittent blood-stained posterior nasal discharge. Five years ago, he had a three-week episode of fitful light headaches. Nasal ventilation, olfactory sensation, and facial sensation were normal; there were no ophthalmological complaints. Coronal  computed tomography (CT) scans revealed soft masses in the bilateral sphenoid sinuses with bone absorption. The patient underwent bilateral functional endoscopic sinus surgery and resection of right nasal papillary masses. Papillary masses and mucosa in both sphenoid sinuses were also removed. The mass in the left sphenoid sinus was diagnosed as two separate entities, one being a primary monophasic epithelial synovial sarcoma and the other an inverted papilloma, while the mass in the right sphenoid sinus was an inverted papilloma. After surgery, the patient underwent radiotherapy and chemotherapy. At the 50-month follow-up visit, there were no signs of recurrence.

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[718]

TÍTULO / TITLE:  - Metastatic leiomyosarcoma of the intrapancreatic bile duct.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Korean Surg Soc. 2013 Jan;84(1):66-9. doi: 10.4174/jkss.2013.84.1.66. Epub 2012 Dec 26.

            ●● Enlace al texto completo (gratuito o de pago) 4174/jkss.2013.84.1.66

AUTORES / AUTHORS:  - Perysinakis I; Katopodi A; Avlonitis S; Georgiadou D; Choreftaki T; Christopoulos G; Margaris I

INSTITUCIÓN / INSTITUTION:  - 3rd Surgical Department, George Gennimatas General Hospital of Athens, Athens, Greece.

RESUMEN / SUMMARY:  - We report the case of a patient with a history of surgically treated pulmonary leiomyosarcoma, presenting with recurrent acute cholangitis and metastatic leiomyosarcoma of the common bile duct. Preoperative examinations had revealed a  high grade malignant neoplasm and bilateral lung metastases. The patient underwent pylorus-preserving pancreaticoduodenectomy and survived for 5.5 years after the first diagnosis.

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[719]

TÍTULO / TITLE:  - Enchondroma of the lunate.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Plast Surg. 2012 Nov;39(6):678-80. doi: 10.5999/aps.2012.39.6.678. Epub 2012 Nov 14.

            ●● Enlace al texto completo (gratuito o de pago) 5999/aps.2012.39.6.678

AUTORES / AUTHORS:  - Kim CH

INSTITUCIÓN / INSTITUTION:  - Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Seoul, Korea.

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[720]

TÍTULO / TITLE:  - Metastatic leiomyosarcoma presenting as bilateral, multifocal breast masses.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2012 Dec 6;2012. pii: bcr2012007188. doi: 10.1136/bcr-2012-007188.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007188

AUTORES / AUTHORS:  - Vasan N; Saglam O; Killelea BK

INSTITUCIÓN / INSTITUTION:  - Yale University School of Medicine, New Haven, CT, USA. neil.vasan@yale.edu

RESUMEN / SUMMARY:  - Here we describe a case of metastatic leiomyosarcoma presenting as bilateral, multifocal breast masses. This case represents the convergence of three rare entities: leiomyosarcoma of unknown primary origin, metastases to the breast and  bilateral, multicentric breast disease.

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[721]

TÍTULO / TITLE:  - Establishment and characterization of a novel lymphangiosarcoma cell line (MO-LAS) compared with the hemangiosarcoma cell line (ISO-HAS).

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Med. 2012 Aug;1(1):39-46. doi: 10.1002/cam4.12. Epub 2012 Jul 13.

            ●● Enlace al texto completo (gratuito o de pago) 1002/cam4.12

AUTORES / AUTHORS:  - Masuzawa M; Masuzawa M; Hamada Y; Arakawa N; Mori M; Ishii M; Nishiyama S

INSTITUCIÓN / INSTITUTION:  - Department of Regulation Biochemistry, Kitasato University School of Allied Sciences Sagamihara, Japan.

RESUMEN / SUMMARY:  - The concept of “lymphangiosarcoma” remains obscure. Therefore, we reported a patient with lymphangiosarcoma, resistant to immunotherapy. The patient presented with impressive and discriminative features: clinically an ill-defined edematous  lesion with lymphorrhea and pathologically atypical vascular channel formation without extravasation of blood, clearly distinguished from common angiosarcoma with hemorrhage. From this case, a lymphangiosarcoma cell line, MO-LAS, was established and its characteristics were compared with the hemangiosarcoma cell line, ISO-HAS. Flow cytometric analysis revealed that MO-LAS was negative for factor VIII-related antigen, but positive for CD31, D2-40, NZ-1, and vascular endothelial growth factor receptor-3 (VEGFR-3), similar to ISO-HAS. However, MO-LAS expressed a much higher level of homeobox gene PROX1, indicating a lymphatic phenotype, compared with ISO-HAS. Furthermore, MO-LAS showed a much lesser expression of oncogenes and much lower sensitivity against lymphokine-activated killer (LAK) cells. Lymphangiosarcoma may be difficult to recognize by the immune system. Conclusively, the establishment of MO-LAS, a novel angiosarcoma cell line bearing lymphatic characters, strongly suggests the  entity of lymphangiosarcoma.

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[722]

TÍTULO / TITLE:  - Follicular dendritic cell sarcoma of the tonsil.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Natl J Maxillofac Surg. 2012 Jan;3(1):62-4. doi: 10.4103/0975-5950.102165.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0975-5950.102165

AUTORES / AUTHORS:  - Mondal SK; Bera H; Bhattacharya B; Dewan K

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Medical College, 88 College Street, Kolkata, West Bengal, India.

RESUMEN / SUMMARY:  - Follicular dendritic cells (FDCs) are non-phagocytic, non-lymphoid cells of immune system, which are necessary for antigen presentation and regulation of the reactions in the germinal centers of lymph node. Follicular dendritic cell sarcoma (FDCS) is unusual and those with an extranodal origin in the head and neck region are extremely rare. Here, we report a case of FDCS of the left tonsil in a 27-year-old male patient. The patient presented with swelling of the left tonsil and resultant difficulty in swallowing for last three months. The tumor was excised and was sent for histopathologic examination. Microscopic examination and immunohistochemical analysis proved the case to be FDCS. After the diagnosis, the patient received post-operative radiotherapy. The patient is on six months follow-up which is uneventful.

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[723]

TÍTULO / TITLE:  - Psammomatoid juvenile aggressive ossifying fibroma of mandible.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Natl J Maxillofac Surg. 2012 Jan;3(1):47-50. doi: 10.4103/0975-5950.102155.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0975-5950.102155

AUTORES / AUTHORS:  - Rao SC; Dandriyal R; Sapra G; Sharma H; Agarwal U; Pandit N

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, I.D.S Bareilly, Uttar Pradesh, India.

RESUMEN / SUMMARY:  - A female patient, aged 14 years, came to dental OPD, with a large swelling of the right mandibular region, progressing since 4-5 years. The swelling initially started with a small size and later it became a large swelling extending from left lower premolar region to right mandibular angle region. Inferiorly, the swelling was extending below the inferior border in the symphysis region. No paresthesia was experienced by the patient. There was quite a marked facial disfigurement of the right mandibular body and symphysis region extending to left side. No other bones were involved and no other abnormalities were found on general physical examination. The medical history was noncontributory. There was  no family history of skeletal disease. The case was surgically treated by segmental resection of the mandible and reconstruction was done using stainless steel reconstruction plate. With the follow-up period of 1 year, there was no recurrence.

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[724]

TÍTULO / TITLE:  - Adenolipoma of the skin arising at neck region.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Korean J Pathol. 2012 Dec;46(6):587-9. doi: 10.4132/KoreanJPathol.2012.46.6.587.  Epub 2012 Dec 26.

            ●● Enlace al texto completo (gratuito o de pago) 4132/KoreanJPathol.2012.46.6.587

AUTORES / AUTHORS:  - Lee HS; Song YS

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Yangji General Hospital, Seoul, Korea.

RESUMEN / SUMMARY:  - We report here a case of adenolipoma of the skin, an unusual variant of lipoma, arising on the neck. A 56-year-old man visited our hospital due to an anterior neck mass. An excisional biopsy was performed. The mass revealed a tan-yellow soft cut surface. We could not find any difference from other lipoma on gross inspection. Microscopically, the mass showed proliferation of mature adipocytes admixed with several eccrine units. The eccrine units were demonstrated by periodic acid-Schiff-positive granules in the secretory portions and by positivity of smooth muscle actin in the myoepithelial cells surrounding the eccrine glands. The tumor was completely excised, and the patient has been followed up without any evidence of recurrence so far.

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[725]

TÍTULO / TITLE:  - Haemorrhagic Epithelioid and Spindle Cell Haemangioma Misdiagnosed as a Metacarpal Enchondroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Hand Surg Eur Vol. 2013 Jan 8.

            ●● Enlace al texto completo (gratuito o de pago) 1177/1753193412471503

AUTORES / AUTHORS:  - Fajardo M; Szabo RM; Gleason BC

INSTITUCIÓN / INSTITUTION:  - Department of Orthopaedic Surgery, University of California, Davis Medical Centre, 4860 Y Street, Suite 3800, Davis, Sacremento, CA, USA.

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[726]

TÍTULO / TITLE:  - Juvenile ossifying fibroma: Psammamatoid variant.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Contemp Clin Dent. 2012 Jul;3(3):330-3. doi: 10.4103/0976-237X.103630.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0976-237X.103630

AUTORES / AUTHORS:  - Aggarwal S; Garg A; Aggarwal A; Ahuja N; Rehman F

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Pathology, Manav Rachna Dental College, Faridabad, Haryana, India.

RESUMEN / SUMMARY:  - Juvenile ossifying fibroma is a rare fibro-osseous lesion containing variable amount of calcified masses, which resembles bone or cementum within a fibrocellular connective tissue stroma. It has variable clinical behavior, highly aggressive in nature including invasion and destruction of adjacent anatomic structures with a strong tendency to recur. We reported a 28-year-old female patient with a growth in the upper left vestibule region extending from canine to molar region with clinical, histopathological, and radiological features are presented. Surgical management was done, and regular follow-up was advised.

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[727]

TÍTULO / TITLE:  - Unusual soft tissue mass of the left lower leg.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Clin Rheumatol. 2013 Jan;19(1):50-1. doi: 10.1097/RHU.0b013e31827cdd8f.

            ●● Enlace al texto completo (gratuito o de pago) 1097/RHU.0b013e31827cdd8f

AUTORES / AUTHORS:  - Hsu SN; Hsu YC; Lin CH; Chiu SK

INSTITUCIÓN / INSTITUTION:  - From the *Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, daggerDepartment of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei; and double daggerDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, Republic of China.

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[728]

TÍTULO / TITLE:  - Angiosarcoma involving solid organs and the gastrointestinal tract with life-threatening bleeding.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Gastroenterol. 2012 Sep;6(3):772-7. doi: 10.1159/000346398. Epub 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000346398

AUTORES / AUTHORS:  - Maeyashiki C; Nagata N; Uemura N

INSTITUCIÓN / INSTITUTION:  - Department of Gastroenterology and Hepatology, National Center for Global Health  and Medicine, Tokyo, Japan.

RESUMEN / SUMMARY:  - We report a rare case of angiosarcoma involving the gastrointestinal tract, liver, spleen, pancreas, kidney, lung and vertebrae, as well as bulky dissemination in the pleuroperitoneal membranes. A 72-year-old man with no history of illness became aware of melena. Laboratory findings revealed anemia, and upper gastrointestinal endoscopy revealed multiple reddish nodules in the stomach and duodenum. However, biopsy specimens showed no evidence of histological features. Computed tomography and fluorodeoxyglucose positron emission tomography showed space-occupying lesions in the spleen, liver and vertebrae. Angiosarcoma was diagnosed by endoscopic ultrasound and fine needle aspiration biopsy of the spleen and repeated endoscopic biopsy of the stomach. We performed laparoscopic splenectomy to avoid rupture of the involved spleen. Due to continuous gastrointestinal bleeding, double balloon endoscopy was performed and multiple bleeding lesions were detected throughout the small intestine. Surgical hemostasis was performed by partial enterectomy, but anemia continued to worsen. Therefore, we conducted transcatheter arterial embolization. Despite attempting several modalities and frequent daily blood transfusion, the anemia did not improve, and the patient expired due to hemorrhagic shock. Subsequent autopsy revealed the cause of death as rupture and bleeding due to disseminated involvement of the small intestine.

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[729]

TÍTULO / TITLE:  - Angioleiomyoma of the auricle.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Plast Surg. 2013 Jan;40(1):68-9. doi: 10.5999/aps.2013.40.1.68. Epub 2013 Jan 14.

            ●● Enlace al texto completo (gratuito o de pago) 5999/aps.2013.40.1.68

AUTORES / AUTHORS:  - Kim HI; Roh SG; Lee NH; Yang KM; Park HS

INSTITUCIÓN / INSTITUTION:  - Department of Plastic and Reconstructive Surgery, Chonbuk National University Medical School, Jeonju, Korea.

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[730]

TÍTULO / TITLE:  - Inflammatory myofibroblastic tumors of the bladder.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Urol Ann. 2012 Sep;4(3):196. doi: 10.4103/0974-7796.102681.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0974-7796.102681

AUTORES / AUTHORS:  - Ganpule AP

INSTITUCIÓN / INSTITUTION:  - Vice-chairman and Consultant Urologist, Department of Urology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, India.

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[731]

TÍTULO / TITLE:  - Huge bilateral renal angiomyolipoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 25;2013. pii: bcr2012007418. doi: 10.1136/bcr-2012-007418.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007418

AUTORES / AUTHORS:  - Shen CH; Tung CL; Yan YH; Cheng MC

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.

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[732]

TÍTULO / TITLE:  - Multimodality management of extremity soft tissue sarcomas-an Indian perspective.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):291-7. doi: 10.1007/s13193-012-0125-7. Epub 2012 Jan 31.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-012-0125-7

AUTORES / AUTHORS:  - Puri A; Gulia A

INSTITUCIÓN / INSTITUTION:  - Orthopaedic Oncologist, Tata Memorial Hospital, Room No: 26, E. Borges Road, Parel, Mumbai, 400 012 India.

RESUMEN / SUMMARY:  - Soft-tissue sarcomas are a rare and heterogeneous group of tumors. The last few decades have seen rapid strides in the management of these complex lesions. The presence of a soft-tissue sarcoma in the extremity is no longer an indication for amputation. Function preserving alternatives for local control in these lesions are the norm without compromising on overall disease survival. Good functional and oncological results can be achieved with a combination of excision of the tumor and where required, suitable adjuvant therapies. These lesions are best managed at specialty centres where the requisite multidisciplinary care can be offered to the patient to optimise results. This article outlines the current understanding and emphasises the multimodality management of these challenging tumors. We also present Indian data of the incidence and oncologic outcomes of these lesions and suggest a treatment algorithm.

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[733]

TÍTULO / TITLE:  - Head and neck soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Surg Oncol. 2011 Dec;2(4):286-90. doi: 10.1007/s13193-012-0127-5. Epub 2012 Mar 6.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s13193-012-0127-5

AUTORES / AUTHORS:  - Aljabab AS; Nason RW; Kazi R; Pathak KA

INSTITUCIÓN / INSTITUTION:  - Head and Neck Surgical Oncology, Department of Surgery, University of Manitoba and Cancer Care Manitoba, 675, Mc Dermot Ave, Winnipeg, R3E 0V9 Canada.

RESUMEN / SUMMARY:  - Sarcomas are malignant neoplasms originating from mesodermal tissues and constitute less than 1% of body’s tumors, including those of the head and neck region. 5-15% of adult sarcomas are in the head and neck region (20% from bones and cartilages and 80% in soft tissues). Commonly encountered sarcomas in the head and neck region are - osteosarcoma, rhabdomyosarcoma, malignant fibrous histiocytoma, fibrosarcoma and angiosarcoma. This article reviews the available literature on head and neck sarcomas.

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[734]

TÍTULO / TITLE:  - Angiosarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Maxillofac Pathol. 2012 Sep;16(3):470-2. doi: 10.4103/0973-029X.102525.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0973-029X.102525

AUTORES / AUTHORS:  - Jaitley S

INSTITUCIÓN / INSTITUTION:  - Department of Oral Pathology and Microbiology, KD Dental College and Hospital, Mathura, Uttar Pradesh, India.

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[735]

TÍTULO / TITLE:  - Craniofacial fibrous dysplasia.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Maxillofac Pathol. 2012 Sep;16(3):465-9. doi: 10.4103/0973-029X.102523.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0973-029X.102523

AUTORES / AUTHORS:  - Jhamb A; Mohanty S; Jhamb PA

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, Santosh Dental College and Hospital, New Delhi, India.

RESUMEN / SUMMARY:  - Fibrous dysplasia can present clinically in varied forms which may appear as collision of different pathologic processes. We report a rare case of craniofacial fibrous dysplasia with coexisting epithelial lined cyst and superimposed osteomyelitis with sequestrum formation. Its clinical features and management with possible hypotheses are described along with the post operative course. Pertinent literature has been reviewed with emphasis on pathogenesis of this unique occurrence.

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[736]

TÍTULO / TITLE:  - Ameloblastic fibroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Oral Maxillofac Pathol. 2012 Sep;16(3):444-5. doi: 10.4103/0973-029X.102515.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0973-029X.102515

AUTORES / AUTHORS:  - Rao SP; Srivastava G; Smitha B

INSTITUCIÓN / INSTITUTION:  - Department of Oral Pathology, Government Dental College, Gunadala, Vijayawada, Andhra Pradesh, India.

RESUMEN / SUMMARY:  - Ameloblastic fibroma is a rare odontogenic tumor comprising neoplastic epithelial and mesenchymal tissues. This lesion was previously considered to be a benign lesion with very limited recurrence rate and malignant transformation. However, recent reports have suggested that this lesion has the potential for recurrence and malignant transformation. In this brief report, we report a case of AF in the context of its high cellularity on histopathological examination.

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[737]

TÍTULO / TITLE:  - Huge mesenchymal chondrosarcoma of mandible.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Maxillofac Oral Surg. 2011 Dec;10(4):340-3. doi: 10.1007/s12663-010-0095-7. Epub 2011 Mar 25.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s12663-010-0095-7

AUTORES / AUTHORS:  - Ram H; Mohammad S; Husain N; Singh G

INSTITUCIÓN / INSTITUTION:  - Department of Oral and Maxillofacial Surgery, CSM Medical University, (Erstwhile  King George‘s Medical University), Lucknow, India.

RESUMEN / SUMMARY:  - Mesenchymal Chondrosarcomas [MCS] are rare subtype of chondrosarcoma. They are distinct tumors arising in unicentric or multicentric locations. It usually appears in second to third decade of life. The neoplasm affects female more frequently than in males. They reveals unusual clinical behavior, characteristic  male histopathological features, and poor prognosis with late recurrences. We report a rare case of MC arising in a 19 year male patient.

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[738]

TÍTULO / TITLE:  - Primary leiomyosarcoma of gallbladder.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Korean Surg Soc. 2012 Dec;83(6):403-7. doi: 10.4174/jkss.2012.83.6.403. Epub 2012 Nov 27.

            ●● Enlace al texto completo (gratuito o de pago) 4174/jkss.2012.83.6.403

AUTORES / AUTHORS:  - Park EY; Seo HI; Yun SP; Kim S; Kim JY; Han KT

INSTITUCIÓN / INSTITUTION:  - Department of Surgery, School of Medicine, Pusan National University, Biomedical  Research Institute, Pusan National University Hospital, Busan, Korea.

RESUMEN / SUMMARY:  - Malignant mesenchymalneoplasms of the gallbladder are extremely rare with only 105 cases of primary gallbladder sarcoma having been described. It has a very aggressive behavior and is usually diagnosed at advanced stages. Therefore, curative surgical management may not be possible. We performed a radical cholecystectomy (S4b + S5 segmentectomy), omentectomy and small bowel resection in a 54-year-old patient with locally invasive leiomyosarcoma of the gallbladder. Further studies are needed to confirm the benefit of aggressive treatment for patients with leiomyosarcoma of the gallbladder.

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[739]

TÍTULO / TITLE:  - The biology of ewing sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - ISRN Oncol. 2013;2013:759725. doi: 10.1155/2013/759725. Epub 2013 Jan 10.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2013/759725

AUTORES / AUTHORS:  - Ross KA; Smyth NA; Murawski CD; Kennedy JG

INSTITUCIÓN / INSTITUTION:  - Hospital for Special Surgery, 523 East 72nd Street, Suite 507, New York, NY 10021, USA.

RESUMEN / SUMMARY:  - Objective. The goal of this study was to review the current literature on the biology of Ewing’s sarcoma, including current treatments and the means by which an understanding of biological mechanisms could impact future treatments. Methods. A search of PubMed and The Cochrane Collaboration was performed. Both preclinical and clinical evidence was considered, but specific case reports were  not. Primary research articles and reviews were analyzed with an emphasis on recent publications. Results. Ewing sarcoma is associated with specific chromosomal translocations and the resulting transcripts/proteins. Knowledge of the biology of Ewing sarcoma has been growing but has yet to significantly impact or produce new treatments. Localized cases have seen improvements in survival rates, but the same cannot be said of metastatic and recurrent cases. Standard surgical, radiation, and chemotherapy treatments are reaching their efficacy limits. Conclusion. Improving prognosis likely lies in advancing biomarkers and early diagnosis, determining a cell(s) of origin, and developing effective molecular therapeutics and antiangiogenic agents. Preclinical evidence suggests the utility of molecular therapies for Ewing sarcoma. Early clinical results also reveal potential for novel treatments but require further development and evaluation before widespread use can be advocated.

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[740]

TÍTULO / TITLE:  - Uterine smooth muscle tumor of uncertain malignant potential: A rare cause of multiple pulmonary nodules.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Med Paediatr Oncol. 2012 Jul;33(3):176-8. doi: 10.4103/0971-5851.103148.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0971-5851.103148

AUTORES / AUTHORS:  - Kotsopoulos IC; Barbetakis N; Asteriou C; Voutsas MG

INSTITUCIÓN / INSTITUTION:  - Department of Gynecologic Oncology, Theagenio Cancer Hospital, Thessaloniki, Greece.

RESUMEN / SUMMARY:  - Smooth muscle tumors of uncertain malignant potential (STUMP) are mesenchymal uterine tumors lying between benign leiomyomas and leiomyosarcomas. Although lung metastases from uterine leiomyosarcoma are common, “STUMP” usually does not metastasize. A case of a 51-year-old woman with progressive dyspnea on exertion and multiple space-occupying lesions in both lungs is presented. She had a history of a total abdominal hysterectomy 3 years ago. Lung biopsy through video-assisted thoracic surgery was consistent with metastatic malignant smooth muscle cell tumor. She received multiple cycles of chemotherapy and died 11 months later. Cell necrosis, atypia and mitotic count are important criteria determining the malignant potential of a uterine smooth muscle tumor. The diagnosis and clinical course of STUMP are not totally and clearly known, and metastasis, especially pulmonary with pleural effusion, is not a common phenomenon. When this occurs, prognosis seems to be poor. Surveillance of these patients should be close and long term.

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[741]

TÍTULO / TITLE:  - Metastasis of primary testicular leiomyosarcoma to the retroperitoneal space.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Indian J Urol. 2012 Jul;28(3):343-6. doi: 10.4103/0970-1591.102723.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0970-1591.102723

AUTORES / AUTHORS:  - Komeya M; Sahoda T; Sugiura S; Sawada T; Kitami K; Iemoto Y

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Fujisawa City Hospital, 2-6-1 Fujisawa, Fujisawa, Kanagawa 251-8550, Japan.

RESUMEN / SUMMARY:  - A 70-year-old man presented with a left scrotal swelling. A computed tomography scan showed an 8-cm left scrotal mass and no metastasis. Radical orchiectomy with high ligation of the spermatic cord was performed. The tumor was classified as a  high-grade leiomyosarcoma of the left testis. An intensive follow-up including repeated computed tomography scans was performed. A computed tomography scan 34 months after the surgery showed a retroperitoneal mass in front of the left kidney. Resection of the mass was performed. Microscopically, the mass was metastatic leiomyosarcoma. Intratesticular leiomyosarcoma is rare; only 18 cases  have been reported. This is the first case in which leiomyosarcoma metastasized to the retroperitoneal space postoperatively. We herein review the literature and discuss how intratesticular leiomyosarcoma metastasized to the retroperitoneal space in this patient.

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[742]

TÍTULO / TITLE:  - Immature fibrous dysplasia: a mixed radio-opaque radiolucent lesion.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2013 Jan 3;2013. pii: bcr2012007934. doi: 10.1136/bcr-2012-007934.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007934

AUTORES / AUTHORS:  - Nair PP; Bhargava D; Thomas S; Shreenivas K

INSTITUCIÓN / INSTITUTION:  - Department of Oral Medicine & Radiology, People’s College of Dental Sciences and  Research Centre, Bhopal, Madhya Pradesh, India.

RESUMEN / SUMMARY:  - Fibrous dysplasia is a bone pathology characterised by abnormal differentiation of osteoblasts leading to replacement of normal marrow and cancellous bone by immature bone and fibrous stroma. A case report of a 20-year-old female patient with a chief complaint of a swelling in the right upper back tooth region, of 6 months duration which was diagnosed as an immature fibrous dysplasia is presented.

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[743]

TÍTULO / TITLE:  - Hibernoma of the thigh: a lipoma-like variant rare tumour mimicking soft tissue sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2012 Nov 30;2012. pii: bcr2012007315. doi: 10.1136/bcr-2012-007315.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007315

AUTORES / AUTHORS:  - Gavriilidis P; Panselinas G; Zafiriou G

INSTITUCIÓN / INSTITUTION:  - Department of Surgical Oncology, Theageneio Anticancer Hospital, Thessaloniki, Greece. pgav7461@yahoo.com

RESUMEN / SUMMARY:  - A 43-year-old Caucasian woman appeared with painless progressively enlarging tumour of the anterior part of the left thigh of approximately 6 months’ duration. A differential imaging diagnosis of liposarcoma or large lipoma was made. An excisional biopsy was performed with complete removal of a large lobulated and encapsulated grossly ovoid mass. Frozen section diagnosis was unidentified lipomatous tumour with no evidence of malignancy. The final pathological diagnosis was lipoma-like hibernoma. The patient’s postoperative course was uneventful and discharged on the seventh postoperative day with full function of the involved leg. Hibernoma is benign tumour and it is not known to recur after complete local excision which is the treatment of choice.

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[744]

TÍTULO / TITLE:  - Pleomorphic rhabdomyosarcoma with pulmonary tumour embolism.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2012 Nov 30;2012. pii: bcr2012007163. doi: 10.1136/bcr-2012-007163.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007163

AUTORES / AUTHORS:  - Abdulaziz S; Geddawy M; Al Efraij K; Jamil MG

INSTITUCIÓN / INSTITUTION:  - Department of Adult Critical Care Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. dr-salman@hotmail.com

RESUMEN / SUMMARY:  - Pulmonary tumour embolism is a known complication of cancer disease. To date, pleomorphic rhabdomyosarcoma has been described once with this entity. We report  a case of pulmonary tumour embolism diagnosed in the operation room after cardiac arrest of a 30-year-old male patient who had surgical amputation of his right upper limb due to recurrent sarcoma, mandating urgent and successful embolectomy.

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[745]

TÍTULO / TITLE:  - Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - BMC Med Genomics. 2012 Dec 5;5:60. doi: 10.1186/1755-8794-5-60.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1755-8794-5-60

AUTORES / AUTHORS:  - Tuna M; Ju Z; Amos CI; Mills GB

INSTITUCIÓN / INSTITUTION:  - Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009, USA. mtuna9@gmail.com.

RESUMEN / SUMMARY:  - ABSTRACT: BACKGROUND: Soft tissue sarcomas (STS) are heterogeneous mesenchymal tumors with diverse subtypes. STS can be classified into two main categories according to the type of genomic alteration: recurrent translocation driven STS,  and non-recurrent translocations. However, little has known about acquired uniparental disomy in STS. METHODS: In this study, we analyzed SNP microarray data to determine the frequency and distribution patterns of acquired uniparental disomy (aUPD) in major soft tissue sarcoma (STS) subtypes using CNAG and R softwares. RESULTS: We identified recurrent aUPD regions specific to alveolar rhabdomyosarcoma with the most frequent at 11p15.4, gastrointestinal stromal tumor at 1p36.11-p35.3, leiomyosarcoma at 17p13.3-p13.1, myxofibrosarcoma at 1p35.1-p34.2 and 16q23.3-q24.1, and pleomorphic liposarcoma at 13q13.2-q13.3 and  13q14.11-q14.2. In contrast, specific recurrent aUPD regions were not identified  in dedifferentiated liposarcoma, Ewing sarcoma, myxoid/round cell liposarcoma, and synovial sarcoma. Strikingly total, centromeric and segmental aUPD regions are more frequent in STS that do not exhibit recurrent translocation events. CONCLUSIONS: Our study yields a detailed map of aUPD across 9 diverse STS subtypes and suggests the potential location of several novel tumor suppressor genes and oncogenes.

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[746]

TÍTULO / TITLE:  - Adenomyosis among samples from hysterectomy due to abnormal uterine bleeding in Ahwaz, southern Iran.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Adv Biomed Res. 2012;1:49. doi: 10.4103/2277-9175.100156. Epub 2012 Aug 28.

            ●● Enlace al texto completo (gratuito o de pago) 4103/2277-9175.100156

AUTORES / AUTHORS:  - Mobarakeh MD; Maghsudi A; Rashidi I

INSTITUCIÓN / INSTITUTION:  - School of Medicine, Jundishapur University of Medical Sciences, Ahwaz, Iran.

RESUMEN / SUMMARY:  - INTRODUCTION: Adenomyosis is one of the most common, yet underdiagnosed, underlying causes of abnormal uterine bleeding (AUB). We aimed to evaluate the prevalence of adenomyosis among subjects who underwent hysterectomy due to AUB. MATERIALS AND METHODS: We studied the pathological specimens from 100 cases of AUB who underwent hysterectomy and were referred to Jundishapur University of Medical Sciences, Ahwaz (Iran) from 2007 to 2010. All specimens were reviewed by  the same pathologist. RESULTS: Pathological findings included adenomyosis 21%, leiomyoma 30%, adenomyosis and leiomyoma 21%, adenomyosis and other pathological  causes 7%, and other pathological causes 21%. The overall prevalence of adenomyosis was 49%. Mean age of the patients was 46.9 +/- 7.8 years and the highest frequency of adenomyosis was observed in the age group 30-60 years. CONCLUSIONS: Overall prevalence of adenomyosis in the population with AUB (49%) that we studied was higher than that in the reports from other populations. Occurrence of isolated adenomyosis in those aged less than 30 years was rare, and adenomyosis was usually accompanied by other lesions.

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[747]

TÍTULO / TITLE:  - Unilateral anhidrosis: a rare presentation of atrial myxoma?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2012 Dec 10;2012. pii: bcr2012007891. doi: 10.1136/bcr-2012-007891.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007891

AUTORES / AUTHORS:  - Gould J

INSTITUCIÓN / INSTITUTION:  - Department of General Medicine, Maidstone & Tunbridge Well NHS Trust, Kent, Tunbridge Wells, UK.

RESUMEN / SUMMARY:  - A 50-year-old Chinese woman, non-smoker, presented with a 6-month history of increased sweating on the right side of her face, exertional chest tightness and  breathlessness. Although the patient presented with increased sweating on the right, further history and examination revealed unilateral, left-sided anhidrosis, left partial ptosis and miosis consistent with Horner’s syndrome. The patient was subsequently investigated with thoracic CT to assess for an apical lung mass (Pancoast tumour). A CT chest ruled out a mediastinal tumour, however,  it revealed a large 60x41&emsp14;mm soft tissue mass arising from the left atrium, protruding across the mitral valve into the left ventricle, suspicious of an intracardiac tumour. The patient was referred urgently for cardiothoracic assessment at a tertiary referral centre and successful open resection was performed. Histology confirmed an atrial myxoma. The patient developed postoperative atrial fibrillation but otherwise made a full recovery.

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[748]

TÍTULO / TITLE:  - Primary alveolar rhabdomyosarcoma: a horrendous presentation with miraculous remission.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2012 Dec 10;2012. pii: bcr2012007657. doi: 10.1136/bcr-2012-007657.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007657

AUTORES / AUTHORS:  - Dhull AK

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

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[749]

TÍTULO / TITLE:  - Joseph Gensoul’s operation for sarcoma of the maxillary antrum, one century before Moore.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J BUON. 2012 Oct-Dec;17(4):801-3.

AUTORES / AUTHORS:  - Tsoucalas G; Karamanou M; Skarpas G; Piagkou M; Skandalakis P; Patsouris E; Androutsos G

INSTITUCIÓN / INSTITUTION:  - Department of History of Medicine, Medical School, University of Athens, Greece.

RESUMEN / SUMMARY:  - Joseph Gensoul is considered an important figure of the 19th century Lyonnais Medical School. His contribution to maxillofacial surgery and his legendary abilities secured him a place in the history of Medicine.

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[750]

TÍTULO / TITLE:  - Superficial acral fibromyxoma of the thumb.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eplasty. 2013;13:ic13. Epub 2013 Jan 21.

AUTORES / AUTHORS:  - Wei C; Fleegler EJ

INSTITUCIÓN / INSTITUTION:  - Division of Plastic Surgery, Department of Surgery, University of Medicine and Dentistry, New Jersey-New Jersey Medical School, Newark.

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[751]

TÍTULO / TITLE:  - Sellar Chordoma Presenting as Pseudo-macroprolactinoma with Unilateral Third Cranial Nerve Palsy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chin J Cancer Res. 2012 Jun;24(2):167-70. doi: 10.1007/s11670-012-0167-y.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11670-012-0167-y

AUTORES / AUTHORS:  - Wang HF; Ma HX; Ma CY; Luo YN; Ge PF

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery.

RESUMEN / SUMMARY:  - We described a 61-year-old female with a sellarchordoma, which presented as pseudo-macroprolactinoma with unilateral third cranial nerve palsy. Physical examination revealed that her right upper lid could not be raised by itself, right eyeball movement limited to the abduction direction, right pupil dilated to 4.5 mm with negative reaction to light, and hemianopsia in bitemporal sides. CT scanning showed a hyperdense lesion at sellar region without bone destruction. Magnetic resonance imaging (MRI) revealed the tumor was 2.3 cmx1.8 cmx2.6 cm, with iso-intensity on T1WI, hyper-intensity on T2WI and heterogeneous enhancement on contrast imaging. Endocrine examination showed her serum prolactin level increased to 1,031.49 mIU/ml. The tumor was sub-totally resected via pterional craniotomy under microscope and was histologically proven to be a chordoma. Postoperatively, she recovered uneventfully but ptosis and hemianopsia remained at the 6th month.

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[752]

TÍTULO / TITLE:  - Malignant fibrous histiocytoma of the gingiva.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2012 Dec 19;2012. pii: bcr2012007400. doi: 10.1136/bcr-2012-007400.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007400

AUTORES / AUTHORS:  - Vijayalakshmi D; Fathima S; Ramakrishnan K; Devi M

INSTITUCIÓN / INSTITUTION:  - Department of Oral & Maxillofacial Pathology, Adhiparasakthi Dental College & Hospital, Tamil Nadu, India.

RESUMEN / SUMMARY:  - Malignant fibrous histiocytoma (MFH) is widely regarded as the commonest soft tissue sarcoma of adulthood which tends to occur in the deep soft tissues of the  extremities and the retroperitoneum. Uncertain histogenesis and numerous subtypes make MFH a rather controversial entity. These tumours are relatively rare in the  head and neck region accounting for only 1-3% of all cases of MFH. MFH exhibits a heterogenous histology of spindle cells in a characteristic storiform pattern with pleomorphic tumour cells and giant cells. A case is reported of an MFH of the gingiva in a 60-year-old woman who presented with a painful swelling originating from the left maxillary gingiva. The clinical, histopathological and  immunohistochemical findings are discussed.

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[753]

TÍTULO / TITLE:  - An update on adenomyosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Diagn Interv Imaging. 2013 Jan;94(1):3-25. doi: 10.1016/j.diii.2012.10.012. Epub  2012 Dec 12.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.diii.2012.10.012

AUTORES / AUTHORS:  - Levy G; Dehaene A; Laurent N; Lernout M; Collinet P; Lucot JP; Lions C; Poncelet E

INSTITUCIÓN / INSTITUTION:  - Women’s Health Imaging, Jeanne-de-Flandre Hospital, Lille Regional University Hospital, 2, avenue Oscar-Lambret, 59037 Lille cedex, France. Electronic address: gwendolinelevy@hotmail.fr.

RESUMEN / SUMMARY:  - Adenomyosis is a common benign uterine pathology that is defined by the presence  of islands of ectopic endometrial tissue within the myometrium. It is asymptomatic in one third of cases, but when there are clinical signs they remain non-specific. It can often be misdiagnosed on sonography as it may be taken to be multiple uterine leiomyomata or endometrial thickening, both of which have a different prognosis and treatment. Adenomyosis is often associated with hormone-dependent pelvic lesions (myoma, endometriosis, or endometrial hyperplasia). It is less commonly connected to infertility or obstetrical complications and indeed any direct relationship remains controversial. The purpose of imaging is to make the diagnosis, to determine the extent of spread (focal or diffuse, superficial or deep adenomyosis, adenomyoma), and to check whether there is any associated disease, in particular endometriosis. The aim of  this article is to provide assistance in recognising adenomyosis on imaging and to identify the pathologies that are commonly associated with it in order to guide the therapeutic management of symptomatic patients. Pelvic ultrasonography  is the first line investigation. Sonohysterography can assist with diagnosis in some cases (pseudothickening of the endometrium seen on sonography). MRI may be used in addition to sonography to back up the diagnosis and to look for any associated disease.

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[754]

TÍTULO / TITLE:  - Minimal deviation adenocarcinoma of the cervix and tumorlets of sex-cord stromal  tumor with annular tubules of the ovary in Peutz-Jeghers syndrome.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Gynecol Oncol. 2013 Jan;24(1):92-5. doi: 10.3802/jgo.2013.24.1.92. Epub 2013 Jan 8.

            ●● Enlace al texto completo (gratuito o de pago) 3802/jgo.2013.24.1.92

AUTORES / AUTHORS:  - Kwon SY; Choe MS; Lee HW; Lee HJ; Shin SJ; Cho CH

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.

RESUMEN / SUMMARY:  - We report 2 cases of minimal deviation adenocarcinoma of the cervix and tumorlets of sex cord tumor with annular tubules (SCTATs) of the ovaries, accompanied by Peutz-Jeghers syndrome. Case 1 is a 36-year-old woman and case 2 is a 35-year-old woman. Grossly, the cervix of both cases showed markedly barrel shaped enlargement with an infiltrating tumor. Microscopically, well-differentiated atypical glands were infiltrating into the entire thickness of the cervix. The ovarian masses in case 1 were diagnosed as metastatic carcinoma in mucinous cystadenoma with tumorlets of SCTATs of the ovaries. Multiple scattered tumorlets of SCTATs were also found in the ovary of case 2. By direct DNA sequencing analysis, a frame shift mutation of the STK11/LKB1 gene was identified in case 1. Case 1 represented the more aggressive clinical course, and although the patient  received additional combined chemo-radiation therapy, she expired 1 year later. In general, mutation of the STK11/LKB1 gene is associated with poor clinical outcome in malignant tumors accompanied by Peutz-Jeghers syndrome.

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[755]

TÍTULO / TITLE:  - A large desmoids-type fibromatosis in left deep buttock and thigh.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Quant Imaging Med Surg. 2012 Jun;2(2):142-4. doi: 10.3978/j.issn.2223-4292.2012.06.02.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2223-4292.2012.06.02

AUTORES / AUTHORS:  - He LC; Zhang N; Zeng XJ; Xiao XZ; Gong HH

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.

RESUMEN / SUMMARY:  - Desmoid-type fibromatosis (DF) is a rare intermediately and locally aggressive tumor that occurs predominantly between puberty and 40 years, with female having  higher incidence than male. This report describes a 48-year-old man with biopsy-proven DF in left intermuscular spatium of buttock and thigh. The mass had a wide longitudinal distribution from femoral neck level to popliteal fossa and measured about 40 cm. Plain CT showed a partially ill-defined mass with an irregular contour, with a density similar or slightly higher than skeletal muscle. On MR images, the tumor showed uneven signal in both T(1)WI and T(2)WI, mainly hyperintense to skeletal muscle and with stripe or patch-like markedly low signal. After contrast injection, the mass showed heterogeneous enhancement.

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[756]

TÍTULO / TITLE:  - Soft-tissue osteoma in the neck paravertebral space.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Quant Imaging Med Surg. 2012 Jun;2(2):139-41. doi: 10.3978/j.issn.2223-4292.2012.04.02.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2223-4292.2012.04.02

AUTORES / AUTHORS:  - Li L; Wang Y; Zhao YF; Lu HZ; Zou SM; Luo DH

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic Imaging, Cancer Hospital & Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China;

RESUMEN / SUMMARY:  - Osteoma is a rare, slow-growing benign neoplasm located primarily in the skeleton. Soft-tissue osteoma is exceedingly rare. We report a case of soft-tissue osteoma occurring in the neck paravertebral space in a 25-year-old man. CT examination demonstrated a cancellous densely ossified mass in the right  side of neck paravertebral space, with irregular lobulation and clear margin, but without relation to the adjacent vertebrae. The mass was resected, and the pathology confirmed soft-tissue osteoma.

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[757]

TÍTULO / TITLE:  - Jejunojejunal intussusception induced by a gastrointestinal stromal tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Surg. 2012;2012:173680. doi: 10.1155/2012/173680. Epub 2012 Nov 19.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/173680

AUTORES / AUTHORS:  - Zakaria AH; Daradkeh S

INSTITUCIÓN / INSTITUTION:  - Istishari Hospital, The University of Jordan, P.O. Box 13261, Amman 11942, Jordan.

RESUMEN / SUMMARY:  - Background. Adult intussusception is a rare entity representing less than 1% of all intestinal obstructions. Diagnosis of the condition is difficult requiring a  high index of suspicion and the utilization of imaging studies, especially CT scans. Diagnostic laparoscopy and/or exploratory laparotomy can be used as a diagnostic and therapeutic intervention. In over 90% of cases, an underlying lead point is identified. In the patient described here, it was a gastrointestinal stromal tumor (GIST), a relatively rare mesenchymal tumor comprising only 0.2-1.0% of the gastrointestinal tract neoplasms and believed to originate from neoplastic transformation of the interstitial cells of Cajal. GISTs may occur anywhere along the gastrointestinal tract, but most commonly arise in the stomach and small intestine. Literature review revealed only few cases reporting GISTs as a leading point of adult’s intussusception. Case Presentation. In this report, we are presenting a rare case of jejunojejunal intussusception in a 78-year-old female patient with a GIST located in the terminal jejunum being the leading point, demonstrating the importance of imaging studies, especially CT scan, laparoscopy, and exploratory laparotomy as diagnostic and therapeutic interventions.

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[758]

TÍTULO / TITLE:  - Extraskeletal myxoid chondrosarcoma with small bowel metastasis causing bowel obstruction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol Med. 2012;2012:621025. doi: 10.1155/2012/621025. Epub 2012 Nov 18.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/621025

AUTORES / AUTHORS:  - Bustinza-Linares E; Socola F; Ernani V; Miller SA; Trent JC

INSTITUCIÓN / INSTITUTION:  - Division of Hematology and Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.

RESUMEN / SUMMARY:  - A 28-year-old female with history of chest wall extraskeletal myxoid chondrosarcoma (EMC) presented to the emergency department complaining of two weeks of lightheadedness and fatigue. Laboratories showed hemoglobin of 7.6 g/dL  and a positive hemoccult test. Upper and lower endoscopies were unremarkable, and the patient was discharged after blood transfusion. The next day she returned to  the ED with left-sided weakness and perioral numbness. Brain CT scan revealed a 6 cm right frontal mass with midline shift and edema that required urgent craniotomy with resection of a hemorrhagic tumor. The patient continued dropping  her hemoglobin, and CT scans showed a rounded 3 cm small bowel mass in the mid ileum. Repeat upper endoscopy revealed a 2 x 2 cm ulcerated mass in the fourth portion of the duodenum. The patient was taken to the operating room and was found to have two lesions; one in the distal duodenum and a second one in the mid ileum causing small bowel intussusception. Pathology was consistent with metastatic EMC grade 2/3, involving the bowel and mesenteric fat. Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft-tissue sarcoma with unique features that distinguishes, it from other sarcomas. It has been often described as a low-grade sarcoma although there are certain characteristics like high mitotic activity and the presence of focal regions of Ki67 staining above 25% that correlate with aggressive behavior of the tumor. This is the first case of EMC metastatic to the small bowel to be reported to the medical community.

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[759]

TÍTULO / TITLE:  - Compression of the digital nerves by a giant periosteal chondroma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Plast Surg Hand Surg. 2012 Dec 17.

            ●● Enlace al texto completo (gratuito o de pago) 3109/2000656X.2012.729652

AUTORES / AUTHORS:  - Santanelli F; Paolini G; Longo B; Laporta R; Pagnoni M

INSTITUCIÓN / INSTITUTION:  - Plastic Surgery Unit, Sant’Andrea Hospital, School of Medicine and Psychology, “Sapienza” University of Rome , Italy.

RESUMEN / SUMMARY:  - Abstract We describe a left-handed man who had a giant periosteal chondroma of the proximal phalanx of the left third finger with compression of the digital neurovascular structures, and the flexor and extensor tendons. Cutaneous pressure thresholds of the digital nerves were tested, showing complete sensory recovery 24 months postoperatively.

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[760]

TÍTULO / TITLE:  - High-dose pre-operative helical tomotherapy (54 Gy) for retroperitoneal liposarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Radiat Oncol. 2012 Dec 17;7:214. doi: 10.1186/1748-717X-7-214.

            ●● Enlace al texto completo (gratuito o de pago) 1186/1748-717X-7-214

AUTORES / AUTHORS:  - Sargos P; Dejean C; Figueiredo BH; Brouste V; Nguyen Bui B; Italiano A; Stoeckle E; Kantor G

INSTITUCIÓN / INSTITUTION:  - Department of Radiation Oncology, Institut Bergonie, Bordeaux, France. g.kantor@bordeaux.unicancer.fr.

RESUMEN / SUMMARY:  - ABSTRACT: PURPOSE: To evaluate the feasibility of pre-operative radiotherapy (54  Gy) with Helical Tomotherapy (HT) followed by surgery. METHODS AND MATERIALS: Ten patients with non-metastatic resectable retroperitoneal liposarcomas were treated by pre-operative tomotherapy (54 Gy) and surgery. Clinical and biological toxicities were evaluated on the CTCAEV3.0 scale. For nine patients, delivered tomotherapy plans were compared with retrospectively-planned dynamic intensity-modulated radiotherapy (IMRT) dosimetric studies. RESULTS: No immediate or late Grade>2 toxicities were observed after radiotherapy. Post-operatively, one patient died and three patients experienced Grade 3 toxicity (two digestive and one metabolic). These toxicities disappeared and only two patients presented  persistent Grade 1 paresthesia. R0 resection was obtained for four patients, R1 for four, and R2 resection for two. With a median follow-up of 26 months, no local or metastatic relapse was observed. Dosimetric comparisons between HT and retrospectively-planned IMRT demonstrate adequate target volume coverage for both techniques. Gastrointestinal sparing is higher with HT with a D200cc reduced by 5 Gy. Integral dose (ID) was increased in HT. CONCLUSIONS: High dose pre-operative  radiotherapy (54 Gy) for retroperitoneal liposarcoma is feasible and mostly well  tolerated. Cumulative toxicity and tolerance depend mainly on patient’s general status. Image-guided radiation therapy (IGRT) is essential, irrespective of the IMRT technique used. Furthermore, HT offers the possibility of sparing selected areas in such complex volumes.

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[761]

TÍTULO / TITLE:  - Papillary fibroelastoma mimicking vegetation of the mitral valve.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cardiovasc Ultrasound. 2012 Dec;20(4):213-5. doi: 10.4250/jcu.2012.20.4.213. Epub 2012 Dec 31.

            ●● Enlace al texto completo (gratuito o de pago) 4250/jcu.2012.20.4.213

AUTORES / AUTHORS:  - Kim SY; Park TH; Lee DY; Lee DH; Cho YR; Kim MH; Kim YD; Hong SH

INSTITUCIÓN / INSTITUTION:  - Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.

RESUMEN / SUMMARY:  - Although cardiac papillary fibroelastoma is rare, it is the most common primary tumor of cardiac valves. The clinical presentation of these tumors varies from asymptomatic to embolic complications. We report an asymptomatic case of papillary fibroelastoma of mitral valve which was diagnosed by transthoracic echocardiography. The tumor was successfully resected by surgery.

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[762]

TÍTULO / TITLE:  - Osteoid osteoma of the trapezoid bone.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Iran Med. 2012 Dec;15(12):777-9. doi: 0121512/AIM.0012.

AUTORES / AUTHORS:  - Jafari D; Najd Mazhar F

INSTITUCIÓN / INSTITUTION:  - Department of Hand Surgery, Shafa Yahyaian Rehabilitation Center, Tehran University of Medical Sciences, Tehran, Iran.fnajdmazhar@yahoo.com.

RESUMEN / SUMMARY:  - Osteoid osteoma is a benign, bone-forming tumor that rarely involves the carpal bones. We report a case of osteoid osteoma of the trapezoid carpal bone with extension to the adjacent second metacarpal bone. Chronic wrist pain and local tenderness were the major clinical signs and symptoms. In chronic wrist pain osteoid osteoma and the possibility of extension to the adjacent bones should be  considered.

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[763]

TÍTULO / TITLE:  - Intramedullary chondrosarcoma of proximal humerus.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Radiol. 2012;2012:642062. doi: 10.1155/2012/642062. Epub 2012 Dec 2.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/642062

AUTORES / AUTHORS:  - Yadav P; Thakkar D; Thind SS

INSTITUCIÓN / INSTITUTION:  - Department of Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Maharashtra, Pune 411006, India.

RESUMEN / SUMMARY:  - Primary chondrosarcoma is the third most frequent primary malignancy of bone after myeloma and osteosarcoma. It is ranging from slow growing nonmetastasising  lesions to highly aggressive lesions. We report a case of primary intramedullary  chondrosarcoma of proximal humerus. A 60-year-old female presented with pain and  hard swelling involving the left arm for 5 months. Radiograph showed a lucent expansile intramedullary lesion with matrix calcification and associated soft tissue mass. CT confirmed the finding. MRI showed a lobulated lesion which is hyperintense on T2WI with low signal fibrous septae. Increased tracer uptake was  seen on bone scan. Histopathology confirmed the radiology diagnosis. The patient  underwent wide resection and endoprosthetic reconstruction of proximal humerus.

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[764]

TÍTULO / TITLE:  - Immunoexpression of alpha2-integrin and Hsp47 in hereditary gingival fibromatosis and gingival fibromatosis-associated dental abnormalities.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Med Oral. Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://www.medicinaoral.com/volu.htm 

            ●● Cita: Medicina Oral: <> Patol Oral Cir Bucal. 2013 Jan 1;18(1):e45-8.

AUTORES / AUTHORS:  - Vieira-Junior JR; de Oliveira-Santos C; Della-Coletta R; Cristianismo-Costa D; Paranaiba LM; Martelli-Junior H

INSTITUCIÓN / INSTITUTION:  - Rua agapanto 139,Sagrada Familia, Montes Claros, Minas Gerais, Brasil, joaorobsonjunior@yahoo.com.br.

RESUMEN / SUMMARY:  - Objective: The purpose of the present study was to investigate the expression of  the alpha2-integrin subunit and heat shock protein 47 (Hsp47) in two families with isolated gingival fibromatosis (GF) form and one family with GF associated with dental abnormalities and normal gingival (NG). Study Design: Immunohistochemistry was performed with antibodies against alpha2-integrin and Hsp47 in specimens from two unrelated families with hereditary gingival fibromatosis (Families 1 and 2) and from one family with a gingival fibromatosis-associated dental abnormality (Family 3); NG samples were used for comparison. The results were analysed statistically. Results: Immunoreactivity for alpha2-integrin and Hsp47 was observed in the nucleus of epithelial cells of  both the basal and suprabasal layer and a more discreet signal was noted in connective tissue in all study samples. Hsp47 showed higher immunoreactivity in Family 2 compared with the other families (p</=0.05). Despite the markup alpha2-integrin was higher in Family 3 there was no statistically significant difference between the families studied (p>/=0.05). Conclusions: Our results confirmed the heterogeneity of GF, such that similar patterns of expression of the condition may show differences in the expression of proteins such as Hsp47. Although no difference in alpha2-integrin expression was observed between GF and  NG groups, future studies are necessary to determine the exact role of this protein in the various forms of GF and whether it contributes to GF pathogenesis.

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[765]

TÍTULO / TITLE:  - An Unexpected Cause of Respiratory Distress and Cyanosis: Cardiac Inflammatory Myofibroblastic Tumor.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Congenit Heart Dis. 2012 Dec 27. doi: 10.1111/chd.12026.

            ●● Enlace al texto completo (gratuito o de pago) 1111/chd.12026

AUTORES / AUTHORS:  - Elkiran O; Karakurt C; Erdil N; Disli OM; Dagli AF

INSTITUCIÓN / INSTITUTION:  - Department of Pediatric Cardiology, Inonu University Faculty of Medicine, Malatya, Turkey.

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumor is an uncommon spindle cell tumor, occurring mainly in children and young adults. It is an extremely rare cardiac tumor especially patients under 1 year. Although it is benign, the tumor may be very aggressive locally. The diagnosis of this unusual pediatric cardiac tumor without pathologic specimens is difficult. We report a rare case of inflammatory myofibroblastic tumors of the right ventricle in a 7-month-old girl presenting with respiratory distress and cyanosis.

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[766]

TÍTULO / TITLE:  - Primary myeloid sarcoma masquerading as an obstructing duodenal carcinoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Report Hematol. 2012;2012:490438. doi: 10.1155/2012/490438. Epub 2012 Nov 29.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/490438

AUTORES / AUTHORS:  - Narayan P; Murthy V; Su M; Woel R; Grossman IR; Chamberlain RS

INSTITUCIÓN / INSTITUTION:  - School of Medicine, St. George’s University, Grenada, West Indies.

RESUMEN / SUMMARY:  - Myeloid Sarcoma (MS), a rare extra hematopoietic carcinoma composed of blast cells, is located primarily in extramedullary sites such as skin, soft tissue, lymph nodes, and bone. MS usually presents in the setting of coexisting acute myeloid leukemia (AML) and myeloproliferative disorders. Gastrointestinal involvement (GI) is extremely rare from nonspecific abdominal symptoms to obstruction. Eight cases of myeloid sarcoma involving the duodenum including the  current case have been reported, overall mean age being 40 years (range 17-71) and M : F ratio 7 : 1. The prognosis of patients with de novo MS cases has been reported to be better than those who have a coexisting leukemia. MS is a rare extramedullary tumor, which should be considered in the differential diagnosis of a soft tissue mass involving the duodenum, especially if there is a coexisting hematological disorder. De novo cases often progress to AML, and current therapy  involves Daunorubicin- and Cytarabine-based chemotherapy. The wide cytogenetic and molecular heterogeneity of MS implies a potential role for more targeted MS therapies, which may offer a curative strategy.

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[767]

TÍTULO / TITLE:  - Giant lipoma of the forearm as a cause of extracarpal compression of the median nerve.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Reumatol Clin. 2012 Dec 22. pii: S1699-258X(12)00177-5. doi: 10.1016/j.reuma.2012.06.006.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.reuma.2012.06.006

AUTORES / AUTHORS:  - Guillen Astete CA; Prieto Morales MD; Zea Mendoza A

INSTITUCIÓN / INSTITUTION:  - Servicio de Reumatologia, Hospital Universitario Ramon y Cajal, Madrid, España. Electronic address: cguillen.hrc@salud.madrid.org.

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[768]

TÍTULO / TITLE:  - Inflammatory myofibroblastic tumor of trachea.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Bronchology Interv Pulmonol. 2013 Jan;20(1):80-3. doi: 10.1097/LBR.0b013e31827cd58f.

            ●● Enlace al texto completo (gratuito o de pago) 1097/LBR.0b013e31827cd58f

AUTORES / AUTHORS:  - Jain S; Chopra P; Agarwal A; Gogia S; Basu A

INSTITUCIÓN / INSTITUTION:  - Departments of *Pathology daggerE.N.T double daggerChest Medicine, Sir Ganga Ram  Hospital, New Delhi, India.

RESUMEN / SUMMARY:  - Inflammatory myofibroblastic tumor (IMT) is an uncommon entity usually encountered among children and involving the lungs. Involvement of trachea, however, is extremely rare with only a few published case reports. The condition  may present with deceptive clinical features. We report a case of tracheal IMT in a 23-year-old female who presented with clinical symptoms mimicking asthma. On further evaluation, she was detected to have a tracheal mass that was diagnosed as IMT on histopathology and was successfully treated surgically. This case report highlights the rarity and diagnostic challenge associated with the condition.

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[769]

TÍTULO / TITLE:  - Characterization of Mesenchymal Stem Cell Subpopulations from Human Amniotic Membrane with Dissimilar Osteoblastic Potential.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Stem Cells. Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://stemcells.alphamedpress.org/ 

            ●● Cita: Stem Cells: <> Dev. 2013 Jan 29.

            ●● Enlace al texto completo (gratuito o de pago) 1089/scd.2012.0359

AUTORES / AUTHORS:  - Leyva-Leyva M; Barrera L; Lopez-Camarillo C; Arriaga-Pizano L; Orozco-Hoyuela G; Carrillo-Casas EM; Calderon-Perez J; Lopez-Diaz A; Hernandez-Aguilar F; Gonzalez-Ramirez R; Kawa S; Chimal-Monroy J; Fuentes-Mera L

INSTITUCIÓN / INSTITUTION:  - 1 Laboratorio de Biologia Molecular e Histocompatibilidad, Direccion de Investigacion Hospital General “Dr. Manuel Gea Gonzalez” , Mexico, Mexico .

RESUMEN / SUMMARY:  - Human fetal mesenchymal stem cells can be isolated from the amniotic membrane (AM-hMSCs) by enzymatic digestion. The biological properties of this cell population have been characterized; however, few studies have focused on the presence of stem cell subpopulations and their differentiation potential. The aim of the present study was to isolate homogeneous AM-hMSC subpopulations based on the coexpression of surface markers. In addition, we aimed to characterize stem cell subpopulations through the detection of typical stem cell markers and its differentiation potential. In this study, fluorescence-activated cell sorting (FACS) was used to positively select for the surface markers CD44, CD73, and CD105. Two subpopulations were isolated: CD44(+)/CD73(+)/CD105(+) (CD105(+)), and CD44(+)/CD73(+)/CD105(-) (CD105(-)). To characterize the cell subpopulations, the expression of pluripotency-associated markers was analyzed by reverse transcriptase-polymerase chain reaction and immunofluorescence. Our results showed positive expression of SOX2, SOX3, PAX6, OCT3/4, and NANOG in the CD105(+) and CD105(-) cell subpopulations. In contrast, we did not detect expression of SSEA4 or FOXD3 in either subpopulation. Immunophenotypes, such as mesenchymal and hematopoietic markers, were studied by FACS analyses. Our data revealed the expression of the CD49a, CD49d, CD29, integrin alpha9beta1, CD44, CD73, and CD105 antigens in both subpopulations. In contrast, CD90, CD45, CD34, CD14, and HLA-DR  expression was not detected. The ability of both subpopulations to differentiate  into osteoblasts, adipocytes, and chondrocytes was evidenced using Alizarin red,  Oil-Red, and Alcian blue staining, respectively. Furthermore, neuronal differentiation was demonstrated by the expression of GFAP and NEURO-D. Interestingly, we observed a dissimilar osteoblastic differentiation potential between the subpopulations. CD105(-) cells showed stronger expression of secreted protein acidic and rich in cysteine (SPARC) and osteonectin, which was associated with more effective calcium deposition, than CD105(+) cells. In conclusion, we described a systematic method for the isolation of hMSCs that was highly reproducible and generated homogeneous cultures for osteoblast differentiation with an efficient capacity for mineralization.

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[770]

TÍTULO / TITLE:  - A hemiclamshell incision for a giant solitary fibrous tumor of the right hemithorax.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Surg. 2012;2012:826454. doi: 10.1155/2012/826454. Epub 2012 Nov 7.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/826454

AUTORES / AUTHORS:  - Kanlioglu Kuman N; Sen S; Cokpinar S; Ceylan E; Tataroglu C; Boga M

INSTITUCIÓN / INSTITUTION:  - Department of Thoracic Surgery, Adnan Menderes University, 09000 Aydin, Turkey.

RESUMEN / SUMMARY:  - A 41-year-old female was admitted with respiratory distress. Chest radiographs showed opacity in the right hemithorax with mediastinal shift. Computed tomography (CT) scan showed a pleural mass with a 22 cm diameter occupying the whole right hemithorax and causing atelectasis. Magnetic resonance imaging (MRI)  showed lower position of the right hemidiaphragm and the liver. Superior vena cava and heart were shifted to left. Presence of infiltration to the adjacent tissues could not be clearly evaluated because of pressure effect. Transthoracic  needle biopsy specimen was reported to be benign. Because of the size and location of the mass, a hemiclamshell incision was chosen, which allowed excellent visualization and complete dissection of the giant tumor. The histopathology of the resected specimen confirmed solitary fibrous tumor. The patient was stabilized by careful observation and treatment. No complication except pneumonia in the postoperative first month occurred during the 22-month follow-up period.

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[771]

TÍTULO / TITLE:  - Primary Ewing’s Sarcoma of Frontoparietal Bone with Major Soft Tissue Extension:  An Unusual Presentation and Review of the Literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Report Pathol. 2012;2012:713836. doi: 10.1155/2012/713836. Epub 2012 Oct 31.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/713836

AUTORES / AUTHORS:  - Gupta A; Bansal S; Chaturvedi S

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi 95, India.

RESUMEN / SUMMARY:  - An 11-year-old girl presented with progressively increasing swelling in scalp of  8-month duration with no neurological deficit. Local examination showed a hard swelling that seemed to be arising from frontal bone. General and systemic examination was normal. MRI revealed a well-defined lytic lesion in left frontoparietal bone with a subgaleal component. The patient was operated upon and excision of tumor with reconstruction of skull was done. Histopathological examination showed a monomorphic small round cell tumor of bone infiltrating into the subcutaneous tissue. Immunohistochemical stain showed diffuse immunopositivity for MIC-2 in tumor cells, thus final diagnosis of Ewing’s sarcoma was made. The patient was kept for follow up for 3 months and had no symptoms.

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[772]

TÍTULO / TITLE:  - An unusual presentation of pelvic leiomyomatosis misdiagnosed as disseminated malignancy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Report Pathol. 2012;2012:394106. doi: 10.1155/2012/394106. Epub 2012 Nov 11.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/394106

AUTORES / AUTHORS:  - Marwah N; Duhan A; Aggarwal G; Sen R

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Pt. B.D. Sharma PGIMS Rohtak, BPS Government Medical College for Women (Sonepat) 1, Haryana, Rohtak 124001, India.

RESUMEN / SUMMARY:  - Leiomyomatosis peritonealis disseminata (LPD) is an exceedingly rare, usually benign condition that clinically simulates a disseminated malignancy, occurring predominantly in women of childbearing age. We present a case of LPD in a postmenopausal woman who had undergone hysterectomy 8 years back for fibroids along with simultaneous presence of pelvic metastasis from breast carcinoma.

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[773]

TÍTULO / TITLE:  - Solitary Giant Intramuscular Myxoid Neurofibroma Resulting in an above Elbow Amputation.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Report Pathol. 2012;2012:353215. doi: 10.1155/2012/353215. Epub 2012 Nov 3.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/353215

AUTORES / AUTHORS:  - Chennakeshaviah G; Ravishankar S; Maggad R; Manjunath GV

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, J.S.S. Medical College, J.S.S. University, Karnataka, Mysore, 570015, India.

RESUMEN / SUMMARY:  - Neurofibromas are uncommon benign tumours and are still rarer in intramuscular locations. They are not detected until they cause a significant damage to the neighbouring tissues. We present a case of a giant intramuscular myxoid neurofibroma of the left forearm which eroded the radius and ulna, restricting the movements at the elbow and wrist joints and causing wrist drop resulting in an above elbow amputation. It was diagnosed by histopathology and was later confirmed by immunohistochemistry.

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[774]

TÍTULO / TITLE:  - Fetal arthrogryposis secondary to a giant maternal uterine leiomyoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Obstet Gynecol. 2012;2012:726732. doi: 10.1155/2012/726732. Epub 2012 Nov 12.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/726732

AUTORES / AUTHORS:  - Vila-Vives JM; Hidalgo-Mora JJ; Soler I; Rubio J; Quiroga R; Perales A

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics, La Fe University Hospital, Bulevar Sur s/n, 46026 Valencia, España.

RESUMEN / SUMMARY:  - Arthrogryposis multiplex congenital is a rare condition defined as contractures in multiple joints at birth due to disorders starting in fetal life. Its etiology is associated with many different conditions and in many instances remains unknown. The final common pathway to all of them is decreased fetal movement (fetal akinesia) due to an abnormal intrauterine environment. Causes of decreased fetal movements may be neuropathic abnormalities, abnormalities of connective tissue or muscle, intrauterine vascular compromise, maternal diseases, and space  limitations within the uterus. When the cause of arthrogryposis is space limitations in uterus, the most common etiology is oligohydramnios. The same can  result from intrauterine tumours as fibroids, although to our knowledge there are only two papers reporting cases of fetal deformities related to uterine leiomyomas. We describe a well-documented exceptional case of arthrogryposis associated with the presence of a large uterine fibroid. It could illustrate the  importance of a careful and appropriate assessment of uterine fibroids before and in the course of a pregnancy considering that they can cause both serious maternal and fetal complications.

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[775]

TÍTULO / TITLE:  - Autocrine role for Gas6 with Tyro3 and Axl in leiomyosarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Target Oncol. 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11523-012-0249-2

AUTORES / AUTHORS:  - El Sayadi H; Pissaloux D; Alberti L; Tabone-Eglinger S; Ranchere D; Decouvelaere AV; Tabone E; Ray-Coquard I; Caux C; Fayette J; Blay JY

INSTITUCIÓN / INSTITUTION:  - Pole des Sciences Cliniques & Centre de Recherche en Cancerologie de Lyon, INSERM UMR5286 Equipe 11, Centre Leon Berard, Lyon, France.

RESUMEN / SUMMARY:  - Leiomyosarcoma (LMS) represent 15 % of adult sarcomas. The aim of this work was to identify novel altered pathways in LMS, which may be of therapeutic value for  patients. Thirteen fresh frozen samples of soft tissue and visceral LMS were analyzed and compared with normal smooth muscle uterine tissue (NSM) for phosphoproteomic profile. Four proteins were found differentially expressed including Tyro3. The functional role of Tyro3 and its ligand Gas6 was investigated in two LMS cell lines, SK-LMS-1 and CNIO-AA. Four proteins and phosphoproteins were differentially expressed in LMS samples vs NSM: A loss of FAK Y397 phosphorylation was observed in all LMSs, while Tyro3, MSH2 and PKC theta were consistently overexpressed. Gas6, the major ligand of Tyro3, was expressed in 8 of the 13 LMS samples, and Gas6 expression highly correlated to Akt Y473 phosphorylation and to a lesser extent to Erk1/2 phosphorylation. SK-LMS-1 and CNIO-AA LMS expressed Tyro3, Axl and Gas6 at high level in CNIO-AA while at low levels in SK-LMS-1. Exposure of both cell lines to foretinib, a tyrosine kinase inhibitor of Met, Axl and Tyro3, reduced cell viability and induced caspase 3/7 activation. Transfection of CNIO-AA with small interfering RNA directed against Tyro3 and Axl genes induced a reduction of the expression of the specific proteins and, when combined, significantly reduced CNIO-AA cell viability. Leiomyosarcomas overexpress Tyro3. Gas6, a ligand of Tyro3, exerts an  autocrine activities though Tyro3 and Axl in a subgroup of LMS.

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[776]

TÍTULO / TITLE:  - Skull-base Ewing sarcoma with multifocal extracranial metastases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Cancer Res Ther. 2012 Oct;8(4):636-8. doi: 10.4103/0973-1482.106584.

            ●● Enlace al texto completo (gratuito o de pago) 4103/0973-1482.106584

AUTORES / AUTHORS:  - Thakar S; Furtado S; Ghosal N; Dilip J; Mahadevan A; Hegde A

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences,  EPIP Area, Whitefield, India.

RESUMEN / SUMMARY:  - Intracranial occurrence of Ewing sarcoma (ES) is unusual, with a skull-base location being anecdotal. We report a 29-year-old man who presented with rapidly  progressive ophthalmoplegia, and was found to be harboring an infiltrative lesion involving the sphenoid sinus, sella, and clivus. He underwent trans-sphenoidal decompression of the lesion which was histologically suggestive of ES. He developed paraparesis 2 weeks after commencing adjuvant therapy. Imaging revealed two thoracic extradural lesions and florid vertebral and pulmonary metastases. This is the first report in indexed literature of a primary intracranial ES on the skull-base with disseminated extracranial disease.

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[777]

TÍTULO / TITLE:  - FDG PET/CT findings in rare sarcomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Rev Esp Med Nucl. Acceso gratuito al texto completo a partir de los 2 años de la fecha de publicación.

            ●● Enlace a la Editora de la Revista http://db.doyma.es/ 

            ●● Cita: Revista Española de Medicina Nuclear: <> Imagen Mol. 2013 Jan 24. pii: S2253-654X(12)00248-X. doi: 10.1016/j.remn.2012.12.003.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.remn.2012.12.003

AUTORES / AUTHORS:  - Ergul N; Aydin M

INSTITUCIÓN / INSTITUTION:  - Department of Nuclear Medicine, Bezmialem Vakif University School of Medicine, Istanbul, Turkey. Electronic address: ngozubuyukoglu@gmail.com.

RESUMEN / SUMMARY:  - The role of FDG PET/CT in management of soft tissue and bone sarcomas has been described in many studies up-to-date. However, contribution of PET/CT to diagnosis and treatment in some types of sarcomas that are seen with low incidence has not been identified properly yet. Clear cell sarcoma, synovial sarcoma of chest and myxoid lyposarcoma are rare types of sarcomas. We aimed to describe the FDG uptake patterns of these rare tumors and find out the role of FDG PET/CT in management of disease.

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[778]

TÍTULO / TITLE:  - Perforated gastrointestinal stromal tumor in the jejunum: A rare cause of acute abdomen.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncol Lett. 2012 Dec;4(6):1244-1246. Epub 2012 Sep 14.

            ●● Enlace al texto completo (gratuito o de pago) 3892/ol.2012.917

AUTORES / AUTHORS:  - Memmi N; Cipe G; Bektasoglu H; Toydemir T; Kadioglu H; Bozkurt S; Buyukpinarbasili N; Karatepe O; Muslumanoglu M

INSTITUCIÓN / INSTITUTION:  - Departments of General Surgery and.

RESUMEN / SUMMARY:  - Gastrointestinal stromal tumors (GIST) are highly frequent mesenchymal tumors of  the digestive tract, which mainly affect the stomach and small intestine. GISTs frequently exist with unclear symptoms. Their initial clinical presentation as acute abdomen due to their perforation is particularly rare. In the present study we report a case of a 59-year-old male presenting with acute abdomen. The final diagnosis revealed a small bowel perforation due to GIST. In this paper, we report the clinical manifestation as well as computed tomography and histopathological findings helpful for the accurate diagnosis of this rare complication of GIST. Emergency laparotomy and complete resection of tumor are essential. Following surgical resection, adjuvant tyrosine kinase inhibitor therapy should be considered for prevention of early recurrence.

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[779]

TÍTULO / TITLE:  - A gastrointestinal stromal tumor of the stomach demonstrating a stepwise progression from low- to high-grade malignancy.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Gastrointest Med. 2012;2012:606832. doi: 10.1155/2012/606832. Epub 2012  Nov 26.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/606832

AUTORES / AUTHORS:  - Nakajima T; Ushijima T; Kihara A; Murata K; Sugiyama T; Tsuneyama K; Imura J; Fukushima J; Horiuchi H

INSTITUCIÓN / INSTITUTION:  - Department of Diagnostic Pathology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, Shinagawa-ku, Tokyo 141-8625, Japan ; Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

RESUMEN / SUMMARY:  - We report a case of a gastrointestinal stromal tumor (GIST) of the stomach that demonstrated a stepwise progression from low- to high-grade malignancy. The patient had been followed for a small gastric submucosal tumor that had turned malignant after 8 years of indolence, manifested by tarry stools. The tumor was enucleated, and gastric GIST was diagnosed. The most significant histological finding was that the tumor comprised two clearly demarcated areas, one with less  aggressive characteristics and the other with highly aggressive characteristics.  The patient exhibited multiple liver metastases 24 months after surgery. Imatinib mesylate was not administered throughout the clinical course because it was not available for clinical use at that time. The patient followed an unfavorable clinical course and died of liver dysfunction 55 months after surgery. Autopsy was performed. By comparing the immunohistochemical profiles of primary and metastatic tumors, it was established that only the tumor cells with highly aggressive characteristics had metastasized.

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[780]

TÍTULO / TITLE:  - Giant gastric lipoma mimicking well-differentiated liposarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pan Afr Med J. 2012;13:16. Epub 2012 Sep 23.

AUTORES / AUTHORS:  - Hamdane MM; Brahim EB; Salah MB; Haouas N; Bouhafa A; Chedly-Debbiche A

INSTITUCIÓN / INSTITUTION:  - Department of pathology, Habib Thameur Hospital. 8 rue Aly Ben Ayed. 1008. Montfleury, Tunis, Tunisia.

RESUMEN / SUMMARY:  - Authors report the case of a 51-year-old man, presenting with epigastralgia of recent onset. Physical exam was unremarkable. Endoscopy revealed a large, ulcerated, submucosal, antral tumor. CT scan reveals an antral mass with fat attenuation. The patient underwent a total gastrectomy. Macroscopic examination identified in the antral wall a 9-cm, well-circumscribed, nodular lesion, with a  yellow, greasy cut surface. On histological examination, the tumor was composed of a mature adipocytes proliferation, showing significant variation in cell size, associated to some lipoblasts. Nuclei were sometimes large, slightly irregular, but without hyperchromasia nor mitosis. Diagnosis of a well-differentiated liposarcoma was suspected and molecular cytogenetic analyses showed no MDM2 nor CDK4 gene amplification on fluorescent in situ hybridization. The diagnosis of lipoma was made. Twelve months following surgery, the patient is doing well.

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[781]

TÍTULO / TITLE:  - Low-grade fibromyxoid sarcoma of the renal pelvis: first report.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Nephrol Urol. 2012 Jul;2(2):87-91. doi: 10.1159/000341191. Epub 2012 Jul 10.

            ●● Enlace al texto completo (gratuito o de pago) 1159/000341191

AUTORES / AUTHORS:  - Alevizopoulos A; Mygdalis V; Tyritzis S; Stravodimos K; Constantinides CA

INSTITUCIÓN / INSTITUTION:  - 1st Academic Urology Department of Athens, Athens University Medical School - LAIKO Hospital, Athens, Greece.

RESUMEN / SUMMARY:  - Sarcomas of the genitourinary tract are quite rare, accounting for 2.1% of all soft tissue sarcomas and have a poor prognosis. Kidney sarcomas are quite rare, representing 1-3% of malignant renal cases. Low-grade fibromyxoid sarcoma (LGFS)  of the kidney is an exceedingly uncommon, indolent but metastasizing soft tissue  sarcoma with deceptively benign-appearing histological features. The estimated 5-year overall survival seems to be over 90%, but very late local relapses and distant metastasis may occur, which underlines the need for a long-term follow-up. We present a case of a 48-year-old male patient with a LGFS located on the renal pelvis. This is probably the first report of LGFS arising from the renal pelvis.

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[782]

TÍTULO / TITLE:  - Cytomorphology of giant cell tumor of bone in pleural fluid.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cytojournal. 2012;9:22. doi: 10.4103/1742-6413.102864. Epub 2012 Oct 23.

            ●● Enlace al texto completo (gratuito o de pago) 4103/1742-6413.102864

AUTORES / AUTHORS:  - Yadav R; Bakhshi S; Mathur SR; Tilak T; Singh G; Iyer VK; Purkait S; Durgapal P

INSTITUCIÓN / INSTITUTION:  - Address: Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

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[783]

TÍTULO / TITLE:  - Periosteal chondrosarcoma of metacarpal bone: Report of a rare entity.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Australas Med J. 2012;5(11):589-92. doi: 10.4066/AMJ.2012.1444. Epub 2012 Nov 30.

            ●● Enlace al texto completo (gratuito o de pago) 4066/AMJ.2012.1444

AUTORES / AUTHORS:  - Kanjirakkadu P K; Moothiringode C S; Ramani KC; Puthoor D

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Amala Institute of Medical Sciences, Thrissur, Kerala, India.

RESUMEN / SUMMARY:  - Chondrosarcomas of the hand are very rare, constituting less than 0.5% of all chondrosarcomas. Metacarpal involvement and juxtacortical location are still rarer. We report a case of periosteal chondrosarcoma of metacarpal bone in a 38-year-old man, who presented with swelling of the left hand. He underwent extended ray amputation with removal of the entire left third metacarpal bone. Histopathological and radiological features of the tumour are described. Recognition of periosteal chondrosarcoma and its differentiation from other surface bone tumours is very important because the prognosis is excellent after adequate local surgery.

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[784]

TÍTULO / TITLE:  - High quality genomic copy number data from archival formalin-fixed paraffin-embedded leiomyosarcoma: optimisation of universal linkage system labelling.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - PLoS One. 2012;7(11):e50415. doi: 10.1371/journal.pone.0050415. Epub 2012 Nov 29.

            ●● Enlace al texto completo (gratuito o de pago) 1371/journal.pone.0050415

AUTORES / AUTHORS:  - Salawu A; Ul-Hassan A; Hammond D; Fernando M; Reed M; Sisley K

INSTITUCIÓN / INSTITUTION:  - Department of Oncology, The University of Sheffield, Medical School, Sheffield, United Kingdom. asalawu@me.com

RESUMEN / SUMMARY:  - Most soft tissue sarcomas are characterized by genetic instability and frequent genomic copy number aberrations that are not subtype-specific. Oligonucleotide microarray-based Comparative Genomic Hybridisation (array CGH) is an important technique used to map genome-wide copy number aberrations, but the traditional requirement for high-quality DNA typically obtained from fresh tissue has limited its use in sarcomas. Although large archives of Formalin-fixed Paraffin-embedded  (FFPE) tumour samples are available for research, the degradative effects of formalin on DNA from these tissues has made labelling and analysis by array CGH technically challenging. The Universal Linkage System (ULS) may be used for a one-step chemical labelling of such degraded DNA. We have optimised the ULS labelling protocol to perform aCGH on archived FFPE leiomyosarcoma tissues using  the 180k Agilent platform. Preservation age of samples ranged from a few months to seventeen years and the DNA showed a wide range of degradation (when visualised on agarose gels). Consistently high DNA labelling efficiency and low microarray probe-to-probe variation (as measured by the derivative log ratio spread) was seen. Comparison of paired fresh and FFPE samples from identical tumours showed good correlation of CNAs detected. Furthermore, the ability to macro-dissect FFPE samples permitted the detection of CNAs that were masked in fresh tissue. Aberrations were visually confirmed using Fluorescence in situ Hybridisation. These results suggest that archival FFPE tissue, with its relative abundance and attendant clinical data may be used for effective mapping for genomic copy number aberrations in such rare tumours as leiomyosarcoma and potentially unravel clues to tumour origins, progression and ultimately, targeted treatment.

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[785]

TÍTULO / TITLE:  - Discovery of biomarkers for osteosarcoma by proteomics approaches.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Sarcoma. 2012;2012:425636. doi: 10.1155/2012/425636. Epub 2012 Nov 21.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/425636

AUTORES / AUTHORS:  - Suehara Y; Kubota D; Kikuta K; Kaneko K; Kawai A; Kondo T

INSTITUCIÓN / INSTITUTION:  - Department of Orthopedic Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

RESUMEN / SUMMARY:  - Osteosarcomas are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well as to develop novel therapeutic strategies. Global protein expression studies, namely, proteomic studies, can offer important clues to understanding the tumor biology that cannot be obtained by other approaches. These studies, such as two-dimensional gel electrophoresis and mass spectrometry, have provided protein expression profiles  of osteosarcoma that can be used to develop novel diagnostic and therapeutic biomarkers, as well as to understand biology of tumor progression and malignancy. In this paper, a brief description of the methodology will be provided followed by a few examples of the recent proteomic studies that have generated new information regarding osteosarcomas.

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[786]

TÍTULO / TITLE:  - Liver metastasis of endometrial stromal sarcoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World J Hepatol. 2012 Dec 27;4(12):415-8. doi: 10.4254/wjh.v4.i12.415.

            ●● Enlace al texto completo (gratuito o de pago) 4254/wjh.v4.i12.415

AUTORES / AUTHORS:  - Ramia JM; De la Plaza R; Garcia I; Perna C; Veguillas P; Garcia-Parreno J

INSTITUCIÓN / INSTITUTION:  - Jose M Ramia, Roberto De la Plaza, Pilar Veguillas, Jorge Garcia-Parreno, Department of Surgery, Hepatopancreatobiliary Surgical Unit, Hospital Universitario de Guadalajara, Guadalajara, 28020 Madrid, España.

RESUMEN / SUMMARY:  - Resection of liver metastases from gynaecological tumours is uncommon. Endometrial stromal sarcomas (ESS) are low incidence gynecological tumours which  can originate in previous sites of endometriosis or following metaplasia of the pelvic peritoneal wall, and which are exceptionally associated with liver metastasis. We present a 68-year-old woman with a ESS and metachronic liver metastasis treated by liver resection. There is very little literature on clinical management about liver metastasis from ESS, but extrapolating the data obtained with liver metastasis from sarcomas and uterine tumours, we should recommend resection as this is considered a resectable extrauterine metastasis. In cases with more sites of extrauterine disease, liver resection should also be  performed if the other sites are resectable.

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[787]

TÍTULO / TITLE:  - Tenosynovial giant cell tumor in the cervico-thoracic junction.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Turk Neurosurg. 2012;22(6):769-71. doi: 10.5137/1019-5149.JTN.315-07.3.

            ●● Enlace al texto completo (gratuito o de pago) 5137/1019-5149.JTN.315-07.3

AUTORES / AUTHORS:  - Okutan O; Roglu IS; Ozen O; Saygili B; Beskonakli E

INSTITUCIÓN / INSTITUTION:  - Medicana Konya Hospital, Department of Neurosurgery, Konya, Turkey. ozerkokutan@hotmail.com

RESUMEN / SUMMARY:  - Tenosynovial giant cell tumor (TGT) rarely arises from the posterior coloumn of the cervical spine. Most lesions of TGT involve the tendon sheath and joint lining of the small joints of the fingers and hands, and consecutively the knee,  ankles and feet, and hips. Rate of extra-articular presentation is about 5-15% in all cases. In this report, a case with paraparesis caused by TGT in the cervico-thoracic junction is presented. The clinical manifestations, diagnosis, and treatment of this unusual condition are discussed. In the treatment of TGT of the vertebral column, the main aim should be total surgical excision of the tumor.

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[788]

TÍTULO / TITLE:  - Breast angiosarcoma secondary to phyllodes tumour.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2012 Dec 3;2012. pii: bcr2012007545. doi: 10.1136/bcr-2012-007545.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007545

AUTORES / AUTHORS:  - Costa S; Graca SA; Ferreira A; Maciel J

INSTITUCIÓN / INSTITUTION:  - Department of General Surgery, Centro Hospitalar Gaia/Espinho, EPE, Gaia, Portugal.

RESUMEN / SUMMARY:  - Angiosarcomas are rare malignant tumours that arise from endothelial cells lining vascular channels, representing 0.04% of malignant neoplasms of the breast. Breast angiosarcomas (BAs) were first described by Schmidt in 1887, and may be primary or secondary to the pre-existing conditions. Primary BAs are more common  in young women and present as a palpable mass. Secondary BAs arise in older patients, frequently 5-6&emsp14;years after radiotherapy, and present as a rash.The authors describe the case of an 83-year-old woman with no history of thoracic radiotherapy or surgery. She had been observed for a breast nodule where biopsy revealed phyllodes tumour. The patient refused surgery and returned 2&emsp14;years later because of an impressive increase in tumour volume and skin  ulceration. She underwent mastectomy with local skin flaps. Histopathological result revealed high-grade angiosarcoma of 15x12&emsp14;cm. There was follow-up without evidence of recurrence, after radiotherapy.

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[789]

TÍTULO / TITLE:  - A perceptual paradigm and psychophysical evidence for hierarchy in scene gist processing.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Vis. 2012 Dec 18;12(13). pii: 16. doi: 10.1167/12.13.16.

            ●● Enlace al texto completo (gratuito o de pago) 1167/12.13.16

AUTORES / AUTHORS:  - Kadar I; Ben-Shahar O

INSTITUCIÓN / INSTITUTION:  - Computer Science Department and the Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

RESUMEN / SUMMARY:  - What is the order of processing in scene gist recognition? Following the seminal  studies by Rosch (1978) and Tversky and Hemmenway (1983) it has been assumed that basic-level categorization is privileged over the superordinate level because the former maximizes both within-category similarity and between-category variance. However, recent research has begun to challenge this view (Oliva & Torralba, 2001; Joubert, Rousselet, Fize, & Fabre-Thorpe, 2007; Loschky & Larson, 2010). Here we study these directions more fundamentally by investigating the perceptual relations between scene categories in a way that allows us to identify the order  of processing of scene categories across taxonomic levels. We introduce the category discrimination paradigm where we briefly present two real scene stimuli  simultaneously and ask human observers whether they belong to the same basic-level category or not (i.e., same/different task). As we show, analysis of  the obtained data reveals a hierarchical perceptual structure between different scene categories and a corresponding hierarchical structure at the perceptual processing level. In particular, we show a new type of evidence to suggest that the decision whether the scene is manmade or natural is made first, and only then more complicated decisions are taken (such as whether a manmade scene is indoor or outdoor) among a smaller set of viable candidate categories. We argue that this hierarchical structure improves performance and efficiency in both biological and artificial gist recognition systems.

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[790]

TÍTULO / TITLE:  - Advances in management of uterine myomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Front Biosci (Elite Ed). 2013 Jan 1;5:12-22.

AUTORES / AUTHORS:  - Duhan N

INSTITUCIÓN / INSTITUTION:  - Department of Obstetrics and Gynecology, Pt. B.D. Sharma Post Graduate Institute  of Medical Sciences, Rohtak, Haryana, India.

RESUMEN / SUMMARY:  - Uterine myomas, the most common benign solid pelvic tumors in women, occur in twenty percent of them in reproductive years and form the most common indication  for hysterectomy. Various factors affect the choice of the best treatment modality for a given patient. Asymptomatic myomas may be managed by careful follow up. Medical therapy should be tried as a first line of treatment for symptomatic myomas while surgical treatment should be reserved only for appropriate indications. Myomectomy would be preferred over hysterectomy in those wishing subsequent childbearing. Preoperative GnRH-analogue treatment reduces the myoma size and vascularity but may render the capsule more difficult to resect. Poor surgical risk women with large symptomatic myomas or those wishing to avoid  major surgical procedures may be offered uterine artery embolization. Serial follow-up for growth and symptoms may be appropriate for asymptomatic perimenopausal women. The present article reviews the available therapeutic modalities for uterine myomas.

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[791]

TÍTULO / TITLE:  - Subcutaneous angiomatoid fibrous histiocytoma mimicking metastatic melanoma.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Report Pathol. 2012;2012:291623. doi: 10.1155/2012/291623. Epub 2012 Dec 20.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/291623

AUTORES / AUTHORS:  - Sparreboom E; Wetzels C; Verdijk M; Mulder S; Blokx W

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Radboud University Nijmegen Medical Centre, P.O. Box 9100, 6500 HB Nijmegen, The Netherlands.

RESUMEN / SUMMARY:  - Angiomatoid fibrous histiocytoma is an uncommon soft-tissue tumor of intermediate malignancy that is often misdiagnosed initially. As there is not one immunohistochemical marker that consequently stains positive or negative for angiomatoid fibrous histiocytoma, molecular diagnostics are becoming more widely  used. So far three translocations have been reported to arise in angiomatoid fibrous histiocytoma: FUS-ATF1, EWSR1-CREB1, or EWSR1-ATF1. We present a case of  angiomatoid fibrous histiocytoma on the upper arm of a 40-year-old female, which  was initially misdiagnosed as metastatic melanoma in a lymph node. Revision of the pathology revealed an angiomatoid fibrous histiocytoma, which was later confirmed by a EWSR1-CREB1 translocation with molecular diagnostics. Furthermore, we review the relevant literature and provide an overview of all available case reports in the past ten years. This case report illustrates the importance for pathologists of knowing the typical pathology features of AFH and integrating immunohistochemical and molecular findings in order to prevent overdiagnosis of lymph node metastasis of a malignancy.

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[792]

TÍTULO / TITLE:  - Renal angiomyolipomas in tuberous sclerosis—rare but potentially life-threatening lesions.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - British Medical J (BMJ). Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://bmj.com/search.dtl 

            ●● Cita: British Medical J. (BMJ): <> Case Rep. 2012 Dec 14;2012. pii: bcr2012007720. doi: 10.1136/bcr-2012-007720.

            ●● Enlace al texto completo (gratuito o de pago) 1136/bcr-2012-007720

AUTORES / AUTHORS:  - Azim A; Rajkumar G

INSTITUCIÓN / INSTITUTION:  - Department of Urology, Basingstoke and North Hampshire Hospital, Basingstoke, UK. adnanazim@doctors.org.uk

RESUMEN / SUMMARY:  - We discuss an 18-year-old girl, diagnosed with tuberous sclerosis complex and known to have renal angiomyolipomas (AMLs) but having no regular urological follow-up, who presented with left-sided abdominal pain and haematuria on urine dipstick testing at the out-of-hours General Practitioner (GP) service. She was diagnosed as having urinary tract infection/pyelonephritis and discharged with simple analgesia and antibiotics. Subsequent imaging of her renal tract demonstrated multiple large AMLs with evidence of recent bleeding, which required arterial embolisation.

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[793]

TÍTULO / TITLE:  - Low-grade myofibroblastic sarcoma of the distal femur.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Surg Case Rep. 2013;4(2):195-9. doi: 10.1016/j.ijscr.2012.11.017. Epub 2012 Nov 23.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.ijscr.2012.11.017

AUTORES / AUTHORS:  - Saito T; Mitomi H; Kurisaki A; Torigoe T; Takagi T; Suehara Y; Okubo T; Kaneko K; Yao T

INSTITUCIÓN / INSTITUTION:  - Department of Human Pathology, Juntendo University, School of Medicine, Japan. Electronic address: tysaitou@juntendo.ac.jp.

RESUMEN / SUMMARY:  - INTRODUCTION: Low-grade myofibroblastic sarcoma (myofibrosarcoma) is described to be a distinct atypical myofibroblastic tumor often with fibromatosis-like features and predilection for head and neck. Low-grade myofibroblastic sarcoma of bone is extremely rare. PRESENTATION OF CASE: A 50-year-old woman was admitted to our hospital because she had experienced right knee pain for 2 years. Plain radiography showed a honeycombed lesion on the right distal femur, and computed tomography showed a bone tumor with cortex destruction invading the soft tissue.  A biopsy specimen from the intraosseous lesion showed a hypocellular area of spindle cell proliferation with dense collagen deposition, which is reminiscent of a histological feature of desmoplastic fibroma. However, histological examination of the extraosseous lesion indicated a slightly hypercellular area containing scattered spindle-shaped atypical cells with enlarged nuclei, suggestive of low-grade sarcoma. Spindle-shaped atypical cells were immunohistochemically positive for SMA. A final diagnosis of low-grade myofibroiblastic sarcoma of the bone was made from a surgically resected specimen. DISCUSSION: The patient was alive and well with no evidence of disease  at 15 months after the surgery without any additional therapy. CONCLUSION: Extensive sampling of a tumor may be necessary to determine the true nature of the tumor and to make an accurate diagnosis.

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[794]

TÍTULO / TITLE:  - Choroidal osteomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - JAMA. Acceso gratuito al texto completo.

            ●● Enlace a la Editora de la Revista http://jama.ama-assn.org/search.dtl 

            ●● Cita: JAMA: <> Ophthalmol. 2013 Jan 1;131(1):124. doi: 10.1001/jamaophthalmol.2013.568.

            ●● Enlace al texto completo (gratuito o de pago) 1001/jamaophthalmol.2013.568

AUTORES / AUTHORS:  - Yiu G; Young LH

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[795]

TÍTULO / TITLE:  - Benign fibrous histiocytoma of the conjunctiva.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Ophthalmol Med. 2012;2012:786260. doi: 10.1155/2012/786260. Epub 2012 Dec 23.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/786260

AUTORES / AUTHORS:  - Ryan G; Glasson B; Foster A

INSTITUCIÓN / INSTITUTION:  - Ophthalmology Department, Caloundra Hospital, Sunshine Coast, West Terrace, Caloundra, QLD 4551, Australia.

RESUMEN / SUMMARY:  - A case is reported on recurrence of a rare conjunctival fibrous histiocytoma (FH) in a 38-year-old man. The lesion was excised and subsequently sent for histopathology and immunostaining resulting in a diagnosis of fibrous histiocytoma (FH). Recurrence was detected 3 months postoperatively requiring a conjunctivosclerokeratomy with cryotherapy and flap. At 6-month followup there was no recurrence detected.

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[796]

TÍTULO / TITLE:  - Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Genes Cancer. 2012 Jul;3(7-8):512-20. doi: 10.1177/1947601912466556.

            ●● Enlace al texto completo (gratuito o de pago) 1177_1947601912466556 [pii

            ●● Enlace al texto completo (gratuito o de pago) 1177/1947601912466556

AUTORES / AUTHORS:  - Maor Y; Yu J; Kuzontkoski PM; Dezube BJ; Zhang X; Groopman JE

INSTITUCIÓN / INSTITUTION:  - Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard  Medical School, Boston, MA, USA.

RESUMEN / SUMMARY:  - Kaposi sarcoma is the most common neoplasm caused by Kaposi sarcoma-associated herpesvirus (KSHV). It is prevalent among the elderly in the Mediterranean, inhabitants of sub-Saharan Africa, and immunocompromised individuals such as organ transplant recipients and AIDS patients. Current treatments for Kaposi sarcoma can inhibit tumor growth but are not able to eliminate KSHV from the host. When the host’s immune system weakens, KSHV begins to replicate again, and  active tumor growth ensues. New therapeutic approaches are needed. Cannabidiol (CBD), a plant-derived cannabinoid, exhibits promising antitumor effects without  inducing psychoactive side effects. CBD is emerging as a novel therapeutic for various disorders, including cancer. In this study, we investigated the effects of CBD both on the infection of endothelial cells (ECs) by KSHV and on the growth and apoptosis of KSHV-infected ECs, an in vitro model for the transformation of normal endothelium to Kaposi sarcoma. While CBD did not affect the efficiency with which KSHV infected ECs, it reduced proliferation and induced apoptosis in those infected by the virus. CBD inhibited the expression of KSHV viral G protein-coupled receptor (vGPCR), its agonist, the chemokine growth-regulated protein alpha (GRO-alpha), vascular endothelial growth factor receptor 3 (VEGFR-3), and the VEGFR-3 ligand, vascular endothelial growth factor C (VEGF-C). This suggests a potential mechanism by which CBD exerts its effects on KSHV-infected endothelium and supports the further examination of CBD as a novel  targeted agent for the treatment of Kaposi sarcoma.

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