Revisiones (todas) *** Reviews (all)



(Conceptos / Keywords: Gliomas; Glioblastoma multiforme; Oligodendroglioma; Astrocytoma, Ependymoma; Medulloblastoma; etc).

December 2012 - January 2013


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TÍTULO / TITLE:  - Chronic myeloid leukemia as a second malignant neoplasm in a patient with medulloblastoma after treatment with chemotherapy and irradiation: a case report  and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pediatr Hematol Oncol. 2013 Feb;30(1):28-9. doi: 10.3109/08880018.2012.748856. Epub 2012 Dec 28.

            ●● Enlace al texto completo (gratuito o de pago) 3109/08880018.2012.748856

AUTORES / AUTHORS:  - Dhir N; Zaky W; Zomorodian T; Dhall G

INSTITUCIÓN / INSTITUTION:  - Neuro-oncology Program, Children’s Hospital Los Angeles , Los Angeles, California , USA.




TÍTULO / TITLE:  - Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Br J Cancer. 2013 Jan 15;108(1):64-71. doi: 10.1038/bjc.2012.504.

            ●● Enlace al texto completo (gratuito o de pago) 1038/bjc.2012.504

AUTORES / AUTHORS:  - Hirst TC; Vesterinen HM; Sena ES; Egan KJ; Macleod MR; Whittle IR

INSTITUCIÓN / INSTITUTION:  - Division of Clinical Neurosciences, University of Edinburgh, FU204, Chancellor’s  Building, Royal Infimary of Edinburgh, Little France Crescent, Edinburgh, EH16 4SA, UK.

RESUMEN / SUMMARY:  - Background:Malignant glioma is an aggressive tumour commonly associated with a dismal outcome despite optimal surgical and radio-chemotherapy. Since 2005 temozolomide has been established as first-line chemotherapy. We investigate the  role of in vivo glioma models in predicting clinical efficacy.Methods:We searched three online databases to systematically identify publications testing temozolomide in animal models of glioma. Median survival and number of animals treated were extracted and quality was assessed using a 12-point scale; random effects meta-analysis was used to estimate efficacy. We analysed the impact of study design and quality and looked for evidence of publication bias.Results:We identified 60 publications using temozolomide in models of glioma, comprising 2443 animals. Temozolomide prolonged survival by a factor of 1.88 (95% CI 1.74-2.03) and reduced tumour volume by 50.4% (41.8-58.9) compared with untreated controls. Study design characteristics accounted for a significant proportion of  between-study heterogeneity, and there was evidence of a significant publication  bias.Conclusion:These data reflect those from clinical trials in that temozolomide improves survival and reduces tumour volume, even after accounting for publication bias. Experimental in vivo glioma studies of temozolomide differ  from those of other glioma therapies in their consistent efficacy and successful  translation into clinical medicine.




TÍTULO / TITLE:  - Palliative and supportive care needs of patients with high-grade glioma and their carers: A systematic review of qualitative literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Patient Educ Couns. 2012 Dec 4. pii: S0738-3991(12)00450-8. doi: 10.1016/j.pec.2012.11.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.pec.2012.11.002

AUTORES / AUTHORS:  - Moore G; Collins A; Brand C; Gold M; Lethborg C; Murphy M; Sundararajan V; Philip J

INSTITUCIÓN / INSTITUTION:  - Centre for Palliative Care, St Vincent’s Hospital, Melbourne, Australia.

RESUMEN / SUMMARY:  - OBJECTIVE: Patients diagnosed with Primary Malignant Glioma (PMG) face substantial challenges with poor prognosis, high symptom burden and care needs. This study aims to collate current literature detailing the supportive and palliative care needs of patients with PMG and their carers, and to subject it to a novel approach of formal evaluation. METHODS: Medline, EMBASE, CINAHL, PsychInfo were searched with core concepts: (1) glioma, (2) high-grade disease, and (3) palliative and supportive care needs. A narrative synthesis approach was  undertaken including a quality appraisal of the 21 included studies. RESULTS: Key themes related to the need for consistent well-delivered information around disease sequelae, treatment, and resources available; health service needs including a key professional identified to coordinate care; the need for psychological and social supports, and clear avenues of communication with treating professionals. CONCLUSION: The literature remains limited in the number  and quality of evidence with two Level I, eight Level II, and eleven Level III studies. The findings call for improved information, communication and support practices to address the complexity and breadth of needs. PRACTICE IMPLICATIONS:  Specialised and individually tailored information, attention to clear, consistent communication and support practices should be incorporated into a future needs-based model of care.




TÍTULO / TITLE:  - Short-term outcome of endoscopic versus microscopic pituitary adenoma surgery: a  systematic review and meta-analysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurol Neurosurg Psychiatry. 2012 Dec 15.

            ●● Enlace al texto completo (gratuito o de pago) 1136/jnnp-2012-303194

AUTORES / AUTHORS:  - Ammirati M; Wei L; Ciric I

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Ohio State University, , Columbus, Ohio, USA.

RESUMEN / SUMMARY:  - Endoscopic transsphenoidal pituitary surgery has become increasingly more popular for the removal of pituitary adenomas. It is also widely recognised that transsphenoidal microscopic removal of pituitary adenomas is a well-established procedure with good outcomes. Our objective was to meta-analyse the short-term results of endoscopic and microscopic pituitary adenoma surgery. We undertook a systematic review of the English literature on results of transsphenoidal surgery, both microscopic and endoscopic from 1990 to 2011. Series with less than 10 patients were excluded. Pooled data were analysed using meta-analysis techniques to obtain estimate of death, complication rates and extent of tumour removal. Complications evaluated included cerebrospinal fluid leak, meningitis, vascular complications, visual complications, diabetes insipidus, hypopituitarism and cranial nerve injury. Data were also analysed for tumour size and sex. 38 studies met the inclusion criteria yielding 24 endoscopic and 22 microscopic datasets (eight studies included both endoscopic and microscopic series). Meta-analysis of the available literature showed that the endoscopic transsphenoidal technique was associated with a higher incidence of vascular complications (p<0.0001). No difference was found between the two techniques in all other variables examined. Meta-analysis of the available literature reveals that endoscopic removal of pituitary adenoma, in the short term, does not seem to confer any advantages over the microscopic technique and the incidence of reported vascular complications was higher with endoscopic than with microscopic  removal of pituitary adenomas. While we recognise the limitations of meta-analysis, our study suggests that a multicentre, randomised, comparative effectiveness study of the microscopic and endoscopic transsphenoidal techniques  may be a reasonable approach towards establishing a true valuation of these techniques.




TÍTULO / TITLE:  - Fourth ventricle rosette-forming glioneuronal tumour in children: an unusual presentation in an 8-year-old patient, discussion and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Childs Nerv Syst. 2012 Dec 14.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00381-012-1993-4

AUTORES / AUTHORS:  - Thurston B; Gunny R; Anderson G; Paine S; Thompson D; Jacques T; Ternier J

INSTITUCIÓN / INSTITUTION:  - Paediatric Neurosurgery, Great Ormond Street Hospital NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.

RESUMEN / SUMMARY:  - INTRODUCTION: Rosette-forming glioneuronal tumour of the fourth ventricle is a rarely described entity. While usually having an indolent course and hence classified as a WHO grade 1 tumour, the precise characteristics and risk of recurrence of this tumour are still unknown. In addition, the preferred treatment modality remains unclear. DISCUSSION: We present a case of an 8-year old with an  early recurrence of 9 months after undergoing a sub-total resection of her tumour. Following further resection, there was no tumour present on the 3-month follow-up. In order to better characterise this tumour entity, we performed a review of the available literature on the subject. We found that it mainly affected young adults and had a female predominance. While initially these tumours were described in the fourth ventricle, the current literature suggests that they may be found in a larger variety of sites within the brain and spinal cord. There are several reports of recurrence occurring between 9 months and 10 years following surgery. There is as yet no feature of the tumour that appears to predict the risk of recurrence. CONCLUSION: This phenomenon warrants further examination to discover if there is a sub-section of tumours that is likely to recur, and until this is established, all patients should be followed up at regular intervals.




TÍTULO / TITLE:  - Long-term response in high-grade optic glioma treated with medically induced hypothyroidism and carboplatin: a case report and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Anticancer Drugs. 2013 Mar;24(3):315-23. doi: 10.1097/CAD.0b013e32835c7a47.

            ●● Enlace al texto completo (gratuito o de pago) 1097/CAD.0b013e32835c7a47

AUTORES / AUTHORS:  - Ashur-Fabian O; Blumenthal DT; Bakon M; Nass D; Davis PJ; Hercbergs A

INSTITUCIÓN / INSTITUTION:  - aThe Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel-Aviv University bTel-Aviv Sourasky Medical Center, Oncology Division, Tel-Aviv cRadiology Institute dDepartment of Pathology, Sheba Medical Center, Tel-Hashomer, Israel eAlbany Medical College, Albany, New York fRadiation Oncology, Cleveland Clinic, Cleveland, Ohio, USA.

RESUMEN / SUMMARY:  - Glioblastoma multiforme (GBM) is the most malignant and frequent brain tumor, with an aggressive growth pattern and poor prognosis despite best treatment modalities. Long-term survival of patients with GBM is rare. Optic glioma represents 0.6-1.2% of all brain tumors. Unlike low-grade optic gliomas in children, optic gliomas in adults are highly aggressive and death usually occurs  in less than a year. Prolonged progression-free survival and survival rates have  been reported in association with induced hypothyroidism in two clinical trials for recurrent GBM. We present the clinical, radiological, and pathological findings in a patient with inoperable GBM of the optic chiasm. Following failure  of initial, standard radiation and temozolomide therapy, chemical hypothyroidism  was induced using the antithyroid thioamide, propylthiouracil, followed by carboplatin chemotherapy. Initial thyroid stimulating hormone, free T4, and free  T3 analysis was carried out and then monthly. This patient responded rapidly to treatment (clinically and with tumor regression within 4 weeks) on two separate occasions with an extended remission period (2.5 years) and prolonged overall survival (4.5 years). We report the successful long-term tumor response to medically induced chemical hypothyroidism in conjunction with carboplatinum chemotherapy of an adult patient with grade IV GBM of the optic chiasm. These clinical observations find mechanistic support from the recent identification of  potent mitogenic actions of the thyroid hormone, L-thyroxine, in malignant glioma through binding to a cognate thyroid hormone receptor on the alphavbeta3 integrin. Approaches to block its activity are now explored in preclinical studies.




TÍTULO / TITLE:  - A meta-analysis of coffee and tea consumption and the risk of glioma in adults.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Causes Control. 2013 Feb;24(2):267-76. doi: 10.1007/s10552-012-0126-4. Epub 2012 Dec 18.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10552-012-0126-4

AUTORES / AUTHORS:  - Malerba S; Galeone C; Pelucchi C; Turati F; Hashibe M; La Vecchia C; Tavani A

INSTITUCIÓN / INSTITUTION:  - Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Via  Giuseppe La Masa 19, 0157, Milan, Italy.

RESUMEN / SUMMARY:  - BACKGROUND: Coffee contains many compounds, including antioxidants, which could prevent cancerogenesis, and coffee has been related with lower incidence of cancer at several sites. Tea is also rich in antioxidants, mainly polyphenols. To provide a quantitative overall estimate on the relation between coffee and tea consumption and glioma, we combined all published data, using a meta-analytic approach. METHODS: In September 2012, a bibliography search was carried out in both PubMed and Embase to identify observational studies providing quantitative estimates on the issue. Pooled estimates of the relative risks (RR) and the corresponding 95 % confidence intervals (CI) were calculated using random-effects models. RESULTS: Six studies (four cohort and two case-control studies) were available for meta-analysis, for a total of about 2100 cases. The summary RRs and 95 % CIs of glioma for drinkers versus non/occasional drinkers were 0.96 (95 % CI: 0.81-1.13) for coffee and 0.86 (95 % CI: 0.78-0.94) for tea, with no heterogeneity between studies. When we compared the highest versus the lowest categories of consumption, the RRs were 1.01 (95 % CI: 0.83-1.22) for coffee, 0.88 (95 % CI: 0.69-1.12) for tea, and 0.75 (95 % CI: 0.54-1.05) for coffee plus  tea. CONCLUSIONS: This meta-analysis, although based on few studies, suggests a lack of association between coffee intake and glioma risk, and a tendency, if any, to a lower risk for tea and coffee plus tea drinkers.




TÍTULO / TITLE:  - A meta-analysis of an association between the XRCC1 polymorphisms and gliomas risk.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurooncol. 2012 Dec 13.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11060-012-1022-1

AUTORES / AUTHORS:  - Li M; Zhou Q; Tu C; Jiang Y

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunnan, China.

RESUMEN / SUMMARY:  - The associations of the X-ray repair cross complementing group 1 (XRCC1) gene single nucleotide polymorphisms (SNPs) Arg194Trp, Arg280His, Arg399Gln with the risk of gliomas have been studied recently, but contradictions exist whether the  XRCC1 SNPs were a risk factor. We examined these associations by performing a meta-analyse. Nine studies tested the associations between XRCC1 SNPs and gliomas were retrieved. Overall odds ratios (ORs) and corresponding 95 % confidence intervals were estimated using genetic models. Heterogeneity and publication bias were evaluated. The pooled OR for Arg194Trp TT versus CC were significant, which  was 2.208 (95 % CI: 1.099, 4.435; P = 0.026), but it was non-significant after removal of the studies which deviated from the Hardy-Weinberg equilibrium (HWE).  The pooled OR for Arg399Gln AA+GA versus GG of genotype methods subgroup and the  low study appraisal score subgroup were significant in the stratification analysis, but the meta-regression results were non-significance. No significant associations were found between the Arg280His SNPs and gliomas’ risk. There was no evidence of publication bias. We conclude that SNPs in XRCC1 are not associated with the risk of gliomas. We should do more work on the relevant variants like those in TERT, RTEL1, EGFR, CDKN2A, CCDC26, and PHLDB1 and their products rather than the XRCC1. More GWAS will also need to involve sufficiently  larger study populations along with analysis of tumor or gender subtypes in order to assess these risks.




TÍTULO / TITLE:  - Discriminating radiation necrosis from tumor progression in gliomas: a systematic review what is the best imaging modality?

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Neurooncol. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11060-013-1059-9

AUTORES / AUTHORS:  - Shah AH; Snelling B; Bregy A; Patel PR; Tememe D; Bhatia R; Sklar E; Komotar RJ

INSTITUCIÓN / INSTITUTION:  - Department of Neurological Surgery, University of Miami, West Building, Suite 306, Miami, FL, 33125, USA.

RESUMEN / SUMMARY:  - Differentiating post radiation necrosis from progression of glioma and pseudoprogression poses a diagnostic conundrum for many clinicians. As radiation  therapy and temozolomide chemotherapy have become the mainstay of treatment for higher-grade gliomas, radiation necrosis and post treatment changes such as pseudoprogression have become a more relevant clinical problem for neurosurgeons  and neurooncologists. Due to their radiological similarity to tumor progression,  accurate recognition of these findings remains paramount given their vastly different treatment regimens and prognoses. However, no consensus has been reached on the optimal technique to discriminate between these two lesions. In order to clarify the types of imaging modalities for recurrent enhancing lesions, we conducted a systematic review of case reports, case series, and prospective studies to increase our current understanding of the imaging options for these common lesions and their efficacy. In particular, we were interested in distinguishing radiation necrosis from true tumor progression. A PubMed search was performed to include all relevant studies where the imaging was used to differentiate between radiation necrosis and recurrent gliomas with post-radiation enhancing lesions. After screening for certain parameters in our study, seventeen articles with 435 patients were included in our analysis including 10 retrospective and 7 prospective studies. The average time from the end of radiation therapy to the onset of a recurrent enhancing lesion was 13.2 months. The most sensitive and specific imaging modality was SPECT with a sensitivity of 87.6 % and specificity of 97.8 %. Based on our review, we conclude that certain imaging modalities may be preferred over other less sensitive/specific techniques. Overall, tests such as SPECT may be preferable in  differentiating TP (tumor progression) from RN (radiation necrosis) due to its high specificity, while nonspecific imaging such as conventional MRI is not ideal.




TÍTULO / TITLE:  - Primary central nervous system histiocytic sarcoma presenting as a postradiation  sarcoma: case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Hum Pathol. 2013 Jan 25. pii: S0046-8177(12)00424-8. doi: 10.1016/j.humpath.2012.11.002.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.humpath.2012.11.002

AUTORES / AUTHORS:  - Wu W; Tanrivermis Sayit A; Vinters HV; Pope W; Misradraei L; Said J

INSTITUCIÓN / INSTITUTION:  - Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1732. Electronic address: winniewu@mednet.ucla.edu.

RESUMEN / SUMMARY:  - Histiocytic sarcoma (HS) is a rare neoplasm that occurs most commonly in the intestinal tract, skin, soft tissue, and lymph node. The incidence of primary central nervous system (CNS) HS is even rarer, with a total of 6 cases reported in the literature. An etiologic link has not been identified for CNS HS, and the  current case of primary CNS HS is unique in that an etiologic link to prior radiation therapy is identified, associated with complex cytogenetic abnormalities in the tumor. Although radiation-associated sarcomas can present as any number of different pathologic entities, this is the first reported case of a radiation-associated CNS HS. The pathologic and immunophenotypic characteristics  of this case, with a nearly obscuring heavy inflammatory infiltrate and expression of monocytic/histiocytic markers (CD163, CD68, CD4, fascin), are characteristic of CNS HS. A discussion of the differential diagnosis and review of relevant literature are presented.




TÍTULO / TITLE:  - Operative management of idiopathic spinal intradural arachnoid cysts in children: a systematic review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Childs Nerv Syst. 2012 Dec 9.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00381-012-1990-7

AUTORES / AUTHORS:  - Evangelou P; Meixensberger J; Bernhard M; Hirsch W; Kiess W; Merkenschlager A; Nestler U; Preuss M

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Pediatric Neurosurgery, University Hospital Leipzig,  Liebigstrasse 20, 04103, Leipzig, Germany.

RESUMEN / SUMMARY:  - BACKGROUND: Spinal intradural arachnoid cysts are rare with only a few patients reported so far. Idiopathic, traumatic, posthemorrhagic, and postinflammatory causes have been reported in the literature. Especially, idiopathic lesions, in which other possible etiological factors have been ruled out, seem to be rare. PATIENTS AND METHODS: We systematically reviewed the literature in regards to localization within the spinal canal, treatment options, complications, and outcome. Additionally, we present management strategies in two progressively symptomatic children less than 3 years of age with idiopathic intradural arachnoid cysts. RESULTS: In total, 21 pediatric cases including the presented cases have been analyzed. Anterior idiopathic spinal arachnoid cysts are predominantly located in the cervical spine in 87.5 % of all cases, whereas posterior cysts can be found at thoracic and thoracolumbar segments in 84.6 % of  the patients. Most children presented with motor deficits (76.2 %). Twenty-five percent of anterior spinal arachnoid cysts caused back pain as the only presenting symptom. Open fenestration by a dorsal approach has been used in the vast majority of cases. No major surgical complications have been reported. Ninety-four percent of all patients did improve or showed no neurological deficits. Recurrence rate after successful surgical treatment was low (9.5 %). CONCLUSION: Idiopathic spinal intradural arachnoid cysts can present with neurological deficits in children. Pathologies are predominantly located in the cervical spine anteriorly and in thoracic and thoracolumbar segments posteriorly  to the spinal cord. In symptomatic cases, microsurgical excision and cyst wall fenestration via laminotomy are recommended. Our radiological, intraoperative, and pathological findings support the cerebrospinal fluid obstruction and vent mechanism theory of arachnoid cysts.




TÍTULO / TITLE:  - Glioblastoma of the cerebellum in children: report of five cases and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Childs Nerv Syst. 2013 Jan 9.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00381-012-1996-1

AUTORES / AUTHORS:  - Reddy GD; Sen AN; Patel AJ; Bollo RJ; Jea A

INSTITUCIÓN / INSTITUTION:  - Division of Pediatric Neurosurgery, Department of Neurosurgery, Texas Children’s  Hospital, Baylor College of Medicine, Houston, TX, USA.

RESUMEN / SUMMARY:  - PURPOSE: Cerebellar glioblastomas in children are rare. As a result, an optimal treatment strategy has not yet been identified. A review of the characteristics of the disease as well as the effectiveness of various therapeutic modalities would help in optimizing the treatment paradigm. METHODS: We performed a detailed clinical, radiographic, and pathologic retrospective review of five patients (three boys and two girls, average age at presentation 7.2 years (range, 3-14 years)) and surveyed the literature for an additional 55 cases. RESULTS: Computed tomography and magnetic resonance imaging usually revealed a large lesion with minimal edema, heterogeneous contrast enhancement, and a discrete border. Subtotal tumor resection was performed in two patients and gross total resection  in three patients. Immunostaining of the tumor cells with antisera to glial fibrillary acidic protein and vimentin was variably positive. Adjuvant therapy included local radiation and chemotherapy in all followed patients. Tumor recurrence was seen in two patients. Patients were followed from 2 months to 3.5  years (mean, 12 months). Two patients were dead at last follow-up with a mean survival of 9.5 months. CONCLUSIONS: The prognosis for pediatric patients with cerebellar glioblastomas is dismal, even when compared to adult counterparts or other malignant posterior fossa tumors in children. Cerebellar glioblastomas have a tendency to recur and disseminate despite treatment with surgery, chemotherapy, and radiation. The poor outcomes seen with this tumor suggest that the optimal treatment strategy has yet to be elucidated and much work needs to be done.




TÍTULO / TITLE:  - Management of pediatric intracranial meningiomas: an analysis of 31 cases and review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Childs Nerv Syst. 2013 Jan 5.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00381-012-2010-7

AUTORES / AUTHORS:  - Ravindranath K; Vasudevan MC; Pande A; Symss N

INSTITUCIÓN / INSTITUTION:  - VHS Hospital, ALNC, Chennai, India, dr.ravindranath08@gmail.com.

RESUMEN / SUMMARY:  - OBJECTIVE: The purpose of this study is to understand the epidemiology, clinical  features, behavior, and the prognostic factors that influence the outcome of intracranial meningiomas in children. METHODS: Thirty-one patients with age less  than 18 years who underwent surgery for intracranial meningiomas during the period of at 1988-2012 at Voluntary Health Services Hospital, Chennai, India were studied. These formed 3.7 % of the total 831 cases of intracranial meningiomas operated at the institute. RESULTS: The study group included 22 (71 %) males and  9 (29 %) females. The mean age of presentation was 15 years, with the youngest being 9 months old. Two (6 %) had evidence of neurofibromatosis type 2 (NF2). The most common symptoms at presentation were seizures in 11 (35.5 %), weakness of limbs in 11 (35.5 %), and raised intracranial pressure in 10 (32 %). Convexity meningiomas were seen in 16 (51 %) and skull base in 15(49 %). Multiple meningiomas was seen in two (6 %) of the patients and intraventricular location was found in one patient (3 %). Two (6 %) had evidence of NF2. Gross total excision was achieved in 26 (83 %) and subtotal excision in 5 (17 %). WHO grade I was found in 20 (64 %) and higher grade was seen in 11 (36 %). The mean follow-up was 46.2 months. Recurrence was seen in 20 patients (64 %). In patients with higher grade or with recurrence resurgery and radiotherapy was given. Three (9 %) had multiple recurrences. On a mean follow-up of 46.2 months, 25 patients (81 %)  were neurologically intact, 5 (16 %) were having moderated disability, and 1 (3 %) patient died. CONCLUSIONS: Childhood meningiomas are uncommon lesions with a slight male predominance. They can have a varied clinical presentation. Higher grade is found more frequently compared with adults. Gross total resection is the goal and in higher grade meningiomas radiotherapy helps as a good adjuvant. Though the rate of recurrence is high, resurgery and radiotherapy gives a good outcome.




TÍTULO / TITLE:  - Disseminated spinal cord astrocytoma with features of gliofibroma: a review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Neuropathol. 2013 Jan 15.

            ●● Enlace al texto completo (gratuito o de pago) 5414/NP300592


RESUMEN / SUMMARY:  - Gliofibromas represent a relativel rare variant of astrocytoma marked by a mixture of astrocytoma and a benign mesenchymal component, usually fibroblastic with collagen deposition. The exact nature of these tumors, due to their rarity,  is still uncertain. This paper reports a case of spinal cord gliofibroma arising  in a 19-year-old female who presented with headaches. Imaging studies suggested widespread, multifocal tumor. Histologically, the tumor was marked by a low grade astrocytoma component (GFAP and S-100 positive) intermixed with bands of collagen. A Ki-67 labeling index of 1.9% was observed. The literature on gliofibromas arising in the spinal cord is reviewed.




TÍTULO / TITLE:  - Giant hypothalamic hamartoma: case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Childs Nerv Syst. 2013 Jan 13.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00381-013-2022-y

AUTORES / AUTHORS:  - Alves C; Barbosa V; Machado M

INSTITUCIÓN / INSTITUTION:  - Pediatric Endocrinology Unit, Hospital Universitario Prof. Edgard Santos, Faculty of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil, cresio.alves@uol.com.br.

RESUMEN / SUMMARY:  - INTRODUCTION: Hypothalamic hamartomas are very rare (1:200,000) and range in size from 17.9 to 18 mm. When their dimensions exceed 30-40 mm, they are classified as giant hypothalamic hamartomas. METHODS: We present a 14-month-old boy with central precocious puberty and gelastic seizures in whom a magnetic resonance imaging scan revealed a giant hypothalamic hamartoma measuring 50 x 50 x 40 mm. RESULTS: In the 11 cases described so far, we found that in comparison to the average-size lesion, giant hypothalamic hamartomas had a lower frequency of precocious puberty, but a similar frequency of seizures. The mean age at diagnosis was younger, and males were more affected than females. Magnetic resonance imaging results were similar with the exception of mass effect. CONCLUSIONS: Giant hypothalamic hamartomas had a higher tendency to adhere to surrounding structures. Their invasiveness and cystic degeneration were frequent  findings among the 11 studies. Surgical removal was ineffective in controlling refractory epilepsy and caused postoperative morbidity in all patients.




TÍTULO / TITLE:  - Cryptococcemia in a patient with glioblastoma: case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Can J Neurol Sci. 2012 Nov;39(6):852-4.

AUTORES / AUTHORS:  - Vellayappan BA; Bharwani L




TÍTULO / TITLE:  - Gamma Knife radiosurgery of cavernous sinus meningiomas: an institutional review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Can J Neurol Sci. 2012 Nov;39(6):757-62.

AUTORES / AUTHORS:  - Zeiler FA; McDonald PJ; Kaufmann AM; Fewer D; Butler J; Schroeder G; West M

INSTITUCIÓN / INSTITUTION:  - Section of Neurosurgery, University of Manitoba, Winnipeg, Manitoba, Canada. umzeiler@cc.umanitba.ca

RESUMEN / SUMMARY:  - INTRODUCTION: Stereotactic radiosurgery offers a unique and effective means of controlling cavernous sinus meningiomas with a low rate of complications. METHODS: We retrospectively reviewed all cavernous sinus meningiomas treated with Gamma Knife (GK) radiosurgery between November 2003 and April 2011 at our institution. RESULTS: Thirty patients were treated, four were lost to follow- up. Presenting symptoms included: headache (9), trigeminal nerve dysesthesias/paresthesias (13), abducens nerve palsy (11), oculomotor nerve palsy (8), Horner’s syndrome (2), blurred vision (9), and relative afferent pupillary defect (1). One patient was asymptomatic with documented tumor growth. Treatment  planning consisted of MRI and CT in 17 of 30 patients (56.7%), the remainder were planned with MRI alone (44.3%). There were 8 males (26.7%) and 22 females (73.3%). Twelve patients had previous surgical debulking prior to radiosurgery. Average diameter and volume at time of radiosurgery was 3.4 cm and 7.9 cm3 respectively. Average dose at the 50% isodose line was 13.5 Gy. Follow-up was available in 26 patients. Average follow-up was 36.1 months. Mean age 55.1 years. Tumor size post GK decreased in 9 patients (34.6%), remained stable in 15 patients (57.7%), and continued to grow in 2 (7.7%). Minor transient complications occurred in 12 patients, all resolving. Serious permanent complications occurred in 5 patients: new onset trigeminal neuropathic pain (2),  frame related occipital neuralgia (1), worsening of pre-GK seizures (1), and panhypopituitarism (1). CONCLUSION: GK offers an effective treatment method for halting meningioma progression in the cavernous sinus, with an acceptable permanent complication rate.




TÍTULO / TITLE:  - Glioblastoma, a brief review of history, molecular genetics, animal models and novel therapeutic strategies.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Arch Immunol Ther Exp (Warsz). 2013 Feb;61(1):25-41. doi: 10.1007/s00005-012-0203-0. Epub 2012 Dec 7.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00005-012-0203-0

AUTORES / AUTHORS:  - Agnihotri S; Burrell KE; Wolf A; Jalali S; Hawkins C; Rutka JT; Zadeh G

INSTITUCIÓN / INSTITUTION:  - Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto Medical Discovery Tower, 101 College St, East Tower, 11-401E, Toronto, ON, M5G 1L7, Canada, Sameer.agnihotri@mail.utoronto.ca.

RESUMEN / SUMMARY:  - Glioblastoma (GBM) is the most common and lethal primary brain tumor. Over the past few years tremendous genomic and proteomic characterization along with robust animal models of GBM have provided invaluable data that show that “GBM”, although histologically indistinguishable from one another, are comprised of molecularly heterogenous diseases. In addition, robust pre-clinical models and a  better understanding of the core pathways disrupted in GBM are providing a renewed optimism for novel strategies targeting these devastating tumors. Here, we summarize a brief history of the disease, our current molecular knowledge, lessons from animal models and emerging concepts of angiogenesis, invasion, and metabolism in GBM that may lend themselves to therapeutic targeting.




TÍTULO / TITLE:  - Current status of immunotherapy and gene therapy for high-grade gliomas.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Cancer Control. 2013 Jan;20(1):43-8.

AUTORES / AUTHORS:  - Marsh JC; Goldfarb J; Shafman TD; Diaz AZ

INSTITUCIÓN / INSTITUTION:  - 21st Century Oncology, Peoria, AZ 85381. jmarsh@rtsx.com.

RESUMEN / SUMMARY:  - BACKGROUND: Despite improvements in surgical technique, radiation therapy delivery, and options for systemic cytotoxic therapy, the median survival for patients with newly diagnosed glioblastoma multiforme remains poor at 15 months with trimodality therapy. Multiple immunologic approaches are being tested to enhance the response of these tumors to existing therapy and/or to stimulate innate immune responses. METHODS: We review the existing data that support the continued development of immunologic therapy in the treatment armamentarium against glioblastoma multiforme, with a focus on clinical data documenting outcomes. RESULTS: In phase I and phase II trials, antitumor vaccines (dendritic  and formalin-fixed) have demonstrated clinical efficacy with mild toxicity, suggesting that innate immune responses can be amplified and directed against these tumors. Suicide gene therapy (gene-mediated cytotoxic therapy) using a number of viral vectors and molecular pathways has also shown efficacy in completed phase I and ongoing phase II trials. In addition, neural stem cells are being investigated as vectors in this approach. CONCLUSIONS: Although phase III data are needed before immunologic therapies can be widely implemented into clinical practice, the existing phase I and phase II data suggest that these therapies can produce meaningful and sometimes durable responses in patients with glioblastoma multiforme with mild toxicity compared with other existing therapies.




TÍTULO / TITLE:  - Mixed pituitary adenoma/craniopharyngioma: clinical, morphological, immunohistochemical and ultrastructural study of a case, review of the literature, and pathogenetic and nosological considerations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pituitary. 2013 Jan 24.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11102-013-0465-5

AUTORES / AUTHORS:  - Finzi G; Cerati M; Marando A; Zoia C; Ferreli F; Tomei G; Castelnuovo P; La Rosa S; Capella C

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy.

RESUMEN / SUMMARY:  - Mixed pituitary adenoma/craniopharyngiomas are very rare tumors. Their pathogenesis is still unclear and it is not known whether they are collision tumors derived from independent stem cells or whether they originate from a single stem cell undergoing divergent differentiation. The latter hypothesis is supported by the close commixture between the two tumor components with transition areas that has been previously described. However, “hybrid” cells with both pituitary adenoma and craniopharyngioma features have never been described.  In this paper we report a case of mixed pituitary adenoma/craniopharyngioma observed in a 75-year-old woman presenting with diplopia and slight increase of serum prolactin, who underwent endoscopic endonasal trans-sphenoidal tumor resection. Histologically, the tumor was composed of a typical pituitary silent subtype 2 ACTH cell adenoma admixed with islands of adamantinomatous craniopharyngioma. Electron microscopy showed that, in addition to distinct silent subtype 2 ACTH and craniopharyngioma cells, there were “hybrid” cells, showing characteristics of both pituitary adenoma and craniopharyngioma, consisting of small dense secretory granules, bundles of cytoplasmic filaments, and desmosomes. This ultrastructural finding was also confirmed by the presence of cells showing nuclear p40 expression and chromogranin A immunoreactivity. The  close commixture between the two components and the ultrastructural and immunohistochemical findings demonstrate a common histogenesis of the two components and support the classification of the neoplasm as a mixed tumor. The patient completely recovered and, 10 months after surgery, head MR confirmed the  complete resection of the lesion.




TÍTULO / TITLE:  - Answer to the Letter to the Editor of F.-A. Dauchy et al. concerning manuscript “Intradural extramedullary primary hydatid cyst of the spine: a case report and review of literature”. Eur Spine J, doi:10.1007/s00586-012-2373-1 by I. Lotfinia, S. Sayyahmelli, A. Mahdkhah, M. Shoja M (2012) : Recurrences in spinal echinococcosis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Eur Spine J. 2012 Dec 6.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s00586-012-2609-0

AUTORES / AUTHORS:  - Lotfinia I; Mahdkhah A

INSTITUCIÓN / INSTITUTION:  - Neuroscience Research Centre, Shohda Hospital, Tabriz University of Medical Sciences, Tabriz, Iran, lotfiniai@yahoo.com.




TÍTULO / TITLE:  - Surgical management of thalamic gliomas: case selection, technical considerations, and review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neurosurg Rev. 2013 Jan 25.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10143-013-0452-3

AUTORES / AUTHORS:  - Sai Kiran NA; Thakar S; Dadlani R; Mohan D; Furtado SV; Ghosal N; Aryan S; Hegde AS

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences,  Whitefield, Bangalore, 560066, India, saikiransssihms@gmail.com.

RESUMEN / SUMMARY:  - This study aimed to identify (1) the thalamic gliomas suitable for surgical resection and (2) the appropriate surgical approach based on their location and the displacement of the posterior limb of the internal capsule (PLIC). A retrospective study over a 5-year period (from 2006 to 2010) was performed in 41  patients with thalamic gliomas. The mean age of these patients was 20.4 years (range, 2-65 years). Twenty (49 %) tumors were thalamic, 19 (46 %) were thalamopeduncular, and 2 (5 %) were bilateral. The PLIC, based on T2-weighted magnetic resonance axial sections, was displaced anterolaterally in 23 (56 %) cases and laterally in 6 (14 %) cases. It was involved by lesion in eight (20 %)  cases and could not be identified in four (10 %) cases. Resection, favored in patients with well-defined, contrast-enhancing lesions, was performed in 34 (83 %) cases, while a biopsy was resorted to in 7 (17 %) cases. A gross total resection or near total resection (>90 %) could be achieved in 26 (63 %) cases. The middle temporal gyrus approach, used when the PLIC was displaced anterolaterally, was the commonly used approach (63.5 %). Common pathologies were pilocytic astrocytoma (58 %) in children and grade III/IV astrocytomas (86 %) in  adults. Preoperative motor deficits improved in 64 % of the patients with pilocytic lesions as compared to 0 % in patients with grade III/IV lesions (P value, 0.001). Postoperatively, two patients (5 %) had marginal worsening of motor power, two patients developed visual field defects, and one patient developed a third nerve paresis. Radical resection of thalamic gliomas is a useful treatment modality in a select subset of patients and is the treatment of  choice for pilocytic astrocytomas. Tailoring the surgical approach, depending on  the relative position of the PLIC, has an important bearing on outcome.




TÍTULO / TITLE:  - Pituicytoma: Report of three cases with review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Pathol Res Pract. 2013 Jan 15;209(1):52-8. doi: 10.1016/j.prp.2012.10.006. Epub 2012 Dec 11.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.prp.2012.10.006

AUTORES / AUTHORS:  - Chakraborti S; Mahadevan A; Govindan A; Sridhar K; Mohan NV; Satish IR; Rudrappa S; Mangshetty S; Shankar SK

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Kasturba Medical College, Mangalore, Karnataka, India.

RESUMEN / SUMMARY:  - Pituicytoma is a rare low-grade tumor (WHO Grade I) of pituicytes involving the sellar-suprasellar region, and originating from the specialized glial cells of the neurohypophysis. Clinically and radiologically, they closely mimic pituitary  adenoma or meningioma. Diagnosis requires histopathological examination of the resected tissue. This uncommon glial neoplasm is a rarity, with only 57 cases reported in the literature so far. We report three cases of pituicytoma (aged between 7 and 24 years) presenting with reduced vision, headache and features of  hypercortisolism in one case. Radiologically, these lesions mimicked meningioma,  hypothalamic chiasmatic glioma and pituitary microadenoma, respectively. The second case is a 7-year-old girl, the youngest case on record. Since this tumor is uncommon, it is frequently misdiagnosed. Awareness of this entity is essential for planning management and treatment. We present a brief review of all cases reported in the medical literature, and describe the clinical symptomatology, associated endocrinological abnormalities, imaging characteristics, behavior and  outcome.




TÍTULO / TITLE:  - Synovial sarcoma in cerebellum: a case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Brain Tumor Pathol. 2012 Dec 8.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s10014-012-0126-9

AUTORES / AUTHORS:  - Xiao GY; Pan BC; Tian XY; Li Y; Li B; Li Z

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Tongjiang Hospital of Guangdong, Nanguo Road East, Shunde District, Foshan, 528300, China.

RESUMEN / SUMMARY:  - Synovial sarcoma is a tumor of unknown origin and is extremely rare in the central nervous system. We present a case involving an unusual cerebellar synovial sarcoma in a male infant. Neuroimaging revealed a large, solid, gadolinium-enhancing mass located in the parenchyma of the right cerebellar hemisphere and associated with multiple cyst formation. Histologically, the tumor was composed of uniform spindle cells with indistinct borders and numerous mitotic figures. The tumor cells were observed to form dense cellular sheets, but in some areas the tumor showed a hemangiopericytomatous vascular pattern consisting of tumor cells arranged around dilated, thin-walled blood vessels. Immunohistochemistry showed that vimentin, CD99 and Bcl-2 were diffusely positive in most cells, and focal reactivity for cytokeratin (AE1/AE3) and S-100 protein was also observed. The tumor cells were, however, negative for CK19, EMA, CD34, synaptophysin, GFAP, desmin, myogenin, and smooth muscle actin. Cytogenetic analysis using fluorescence in situ hybridization demonstrated the translocation  t(X;18)(p11;q11). A diagnosis of primary cerebellar monophasic synovial sarcoma was made. To our knowledge, this is the first report of a synovial sarcoma in brain parenchyma. The present case indicates that it is essential to select the appropriate immunohistochemical panel and-especially-perform molecular analysis to accurately diagnose intracranial spindle cell tumors.




TÍTULO / TITLE:  - Congenital craniopharyngioma: a case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Endocrinol Metab. 2012;25(11-12):1181-3. doi: 10.1515/jpem-2012-0251.

            ●● Enlace al texto completo (gratuito o de pago) 1515/jpem-2012-0251

AUTORES / AUTHORS:  - Chentli F; Belhimer F; Kessaci F; Mansouri B

RESUMEN / SUMMARY:  - Abstract Introduction: Although craniopharyngiomas are congenital tumors, they are rarely diagnosed in the prenatal or early neonatal period. Sometimes they are very large, debilitating and life-threatening, as in the case discussed here. Observation: A 21-month-old girl was referred for craniopharyngioma that had been diagnosed at 5 months because of neurologic complications. The pregnancy and birth were considered to be unremarkable. The birth weight was 4 kg, length 53 cm, head circumference 38 cm (n=35+/-1). Brain CT revealed active hydrocephalus caused by a very large solid, cystic and calcified supra sellar mass. MRI confirmed the process measuring 5 cm in height, multidirectional, diving into pituitary sella, displacing the brainstem. After several resections and reservoir drainage, the patient was blind, hemiparetic and she convulsed frequently. The patient died when she was 2. Conclusion: The large head circumference at birth, the size of the tumor, blindness, and hemiparesis observed before the age of 5 months suggested an antenatal process unnoticed because of inadequate gestational monitoring.




TÍTULO / TITLE:  - Editorial Comment to Prostate cancer may trigger paraneoplastic limbic encephalitis: A case report and a review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Int J Urol. 2013 Jan 10. doi: 10.1111/iju.12075.

            ●● Enlace al texto completo (gratuito o de pago) 1111/iju.12075

AUTORES / AUTHORS:  - Munshi SK; Raghunathan SK

INSTITUCIÓN / INSTITUTION:  - Nottingham University Hospitals NHS Trust, Nottingham, UK. sunil.munshi@nuh.nhs.uk.




TÍTULO / TITLE:  - Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: a review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Brain Imaging Behav. 2013 Jan 18.

            ●● Enlace al texto completo (gratuito o de pago) 1007/s11682-012-9220-1

AUTORES / AUTHORS:  - Deprez S; Billiet T; Sunaert S; Leemans A

INSTITUCIÓN / INSTITUTION:  - Radiology, University Hospital Leuven & Department of Imaging and Pathology, KU Leuven, Leuven, Belgium, sabine.deprez@uzleuven.be.

RESUMEN / SUMMARY:  - Patients with non-central nervous system cancers often experience subtle cognitive deficits after treatment with cytotoxic agents. Therapy-induced structural changes to the brain could be one of the possible causes underlying these reported cognitive deficits. In this review, we evaluate the use of diffusion tensor imaging (DTI) for assessing possible therapy-induced changes in  the microstructure of the cerebral white matter (WM) and provide a critical overview of the published DTI research on therapy-induced cognitive impairment. Both cross-sectional and longitudinal DTI studies have demonstrated abnormal microstructural properties in WM regions involved in cognition. These findings correlated with cognitive performance, suggesting that there is a link between reduced “WM integrity” and chemotherapy-induced impaired cognition. In this paper, we will also introduce the basics of diffusion tensor imaging and how it can be applied to evaluate effects of therapy on structural changes in cerebral WM. The review concludes with considerations and discussion regarding DTI data interpretation and possible future directions for investigating therapy-induced WM changes in cancer patients. This review article is part of a Special Issue entitled: Neuroimaging Studies of Cancer and Cancer Treatment.



TÍTULO / TITLE:  - Minimally invasive surgery for benign intradural extramedullary spinal meningiomas: experience of a single institution in a cohort of elderly patients and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Clin Interv Aging. 2012;7:557-64. doi: 10.2147/CIA.S38923. Epub 2012 Dec 6.

            ●● Enlace al texto completo (gratuito o de pago) 2147/CIA.S38923

AUTORES / AUTHORS:  - Iacoangeli M; Gladi M; Di Rienzo A; Dobran M; Alvaro L; Nocchi N; Maria LG; Somma D; Colasanti R; Scerrati M

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Universita Politecnica delle Marche, Umberto I General Hospital, Ancona, Italy.

RESUMEN / SUMMARY:  - Meningiomas of the spine are the most common benign intradural extramedullary lesions and account for 25%-46% of all spinal cord tumors in adults. The goal of  treatment is complete surgical resection while preserving spinal stability. Usually, these lesions occur in the thoracic region and in middle-aged women. Clinical presentation is usually nonspecific and the symptoms could precede the diagnosis by several months to years, especially in older people, in whom associated age-related diseases can mask the tumor for a long time. We report a series of 30 patients, aged 70 years or more, harboring intradural extramedullary spinal meningiomas. No subjects had major contraindications to surgery. A minimally invasive approach ( hemilaminectomy and preservation of the outer dural layer) was used to remove the tumor, while preserving spinal stability and improving the watertight dural closure. We retrospectively compared the outcomes  in these patients with those in a control group subjected to laminectomy or laminotomy with different dural management. In our experience, the minimally invasive approach allows the same chances of complete tumor removal, while providing a better postoperative course than in a control group.




TÍTULO / TITLE:Popromienne guzy opon mozgowo-rdzeniowych. Opis osmiu przypadkow i przeglad pismiennictwa.

TÍTULO / TITLE:  - Radiation-induced tumours of meninges. Report on eight cases and review of the literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Neurol Neurochir Pol. 2012;46(6):542-552.

AUTORES / AUTHORS:  - Kunert P; Matyja E; Prokopienko M; Marchel A

INSTITUCIÓN / INSTITUTION:  - Przemyslaw Kunert, Katedra i Klinika Neurochirurgii, Warszawski Uniwersytet Medyczny, ul. Banacha 1A, 02-097 Warszawa, fax: +48 22 658 36 53, e-mail: pkunert@wp.pl.

RESUMEN / SUMMARY:  - Background and purpose: Despite their rarity, post-radiation meningeal tumours seem to be a growing problem due to the increasing application of radiation therapy. The aim of the study was to ascertain the specific features of these tu-mours. Material and methods: Among 433 intracranial meningeal tumours treated  from 2000 to 2008, eight cases (2%) have been presumed to be associated with high-dose therapeutic radiation for previous neoplasm of the head (7) or neck (1). On average, tumours were diagnosed 24 years after irradiation. All patients  had a solitary meningeal tumour, but two of them also developed other neoplasms in the irradiated area. Results: All tumours were microsurgically removed. The post-operative course was uncomplicated in two cases only. In the remaining 6 (75%), complications included liquorrhoea (2), brain oedema (1), venous thrombosis (1), bleeding into the tu-mour bed (1) and focal deficit due to manipulation (3). Most tumours (5) were WHO grade I meningiomas. These be-nign meningiomas exhibited some peculiar histological features, including focal increase of cellularity, focal enhancement of proliferation index, pleomorphism of nuclei, occasional mitotic figures and, in one case, evidence of brain invasion. One meningioma was assigned to WHO grade II, one to WHO grade III and one appe-ared to be meningeal fi-brosarcoma. The event-free survival and overall  survival rate at 4.4 years of follow-up were 63% and 75%, respectively. Conclusions: Radiation-induced tumours of the meninges show certain characteristic histopathological features, which may promote invasiveness of the  tumour and higher risk of malignancy.




TÍTULO / TITLE:  - The XRCC1 Arg194Trp polymorphism is not a risk factor for glioma: A meta-analysis involving 1,440 cases and 2,562 controls.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Ther Med. 2012 Dec;4(6):1057-1062. Epub 2012 Sep 18.

            ●● Enlace al texto completo (gratuito o de pago) 3892/etm.2012.716

AUTORES / AUTHORS:  - Zhang L; Wang Y; Qiu Z; Luo J; Zhou Z; Shu W

INSTITUCIÓN / INSTITUTION:  - Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing 400038;

RESUMEN / SUMMARY:  - Previous reports have indicated that the X-ray repair cross-complementing gene 1  (XRCC1) Arg194Trp polymorphism may be a risk factor for several types of cancer.  Published studies on the association of XRCC1 Arg194Trp polymorphisms with glioma risk have yeilded conflicting results. The present study aimed to obtain a more precise estimation of this association. Meta-analyses assessing the association of the XRCC1 Arg194Trp variation with glioma were conducted and subgroup analyses based on ethnicity and source of controls were also performed. Eligible studies were identified during the period before May 2012. A total of four case-control studies comprising 1,440 cases and 2,562 controls were finally selected for analysis. The overall data failed to indicate a significant association of the XRCC1 Arg194Trp polymorphism with glioma risk [Trp vs. Arg: odds ratio (OR) = 1.01, 95% confidence interval (95% CI) = 0.77-1.33; Trp/Trp vs. Arg/Arg: OR = 1.56, 95% CI = 0.96-2.54; dominant model: OR = 0.98, 95% CI = 0.74-1.31; recessive model: OR = 1.48, 95% CI = 0.92-2.38]. Similarly, in the subgroup analysis based on ethnicity and source of controls, no associations were observed. In conclusion, the results of the present study failed to suggest an association between the XRCC1 Arg194Trp polymorphism and glioma risk. Further large and well-designed studies are required to confirm this conclusion.



TÍTULO / TITLE:  - Clinicopathological features of meningioangiomatosis associated with meningioma:  a case report with literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Case Rep Oncol Med. 2012;2012:296286. doi: 10.1155/2012/296286. Epub 2012 Nov 5.

            ●● Enlace al texto completo (gratuito o de pago) 1155/2012/296286

AUTORES / AUTHORS:  - Cui H; Shi H; Chen X; Wang W; Lai R; Han A

INSTITUCIÓN / INSTITUTION:  - Department of Pathology, Guangzhou General Hospital of PLA, Guangzhou 510010, China.

RESUMEN / SUMMARY:  - Aim. To analyze the clinicopathological features of meningioangiomatosis (MA) associated with meningioma. Methods. We present one case of MA associated with meningioma. Histopathological examination and immunohistochemistry were used. Results. The age of the patient was 33-year-old man. Histopathologically, MA was  characterized by vascular proliferation with perivascular meningothelial cells and/or fibroblast proliferation, entrapped glial islands. In addition, MA was associated with transitional meningioma. The patient was alive without evidence of recurrence at 18 months after mass resection. Conclusion. MA associated with meningioma is an extremely rare lesion. The differential diagnosis includes cortical invasion by meningioma and intracerebral schwannoma. Patients with MA associated with meningioma often have a good prognosis after operation.



TÍTULO / TITLE:  - Adult medulloblastoma, from spongioblastoma cerebelli to the present day: a review of treatment and the integration of molecular markers.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Oncology (Williston Park). 2012 Nov;26(11):1083-91.

AUTORES / AUTHORS:  - Shonka N; Brandes A; De Groot JF

INSTITUCIÓN / INSTITUTION:  - Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, Nebraska 68198-7680, USA. nshonka@unmc.edu

RESUMEN / SUMMARY:  - Although they represent the most common malignant brain tumor in the pediatric population, medulloblastomas are rare in adults, with an incidence of 0.5 per million. With only one exception, all of the prospective clinical trials in this  disease have been done in the pediatric population, and therefore therapy for adult medulloblastoma has been either extrapolated from the pediatric literature  or based on retrospective reviews. A growing body of literature underscores the genetic similarities between adult and pediatric disease, which may allow tailored therapy directed towards specific molecular pathways and may have an impact on clinical outcomes. Here we present the history, staging system, and treatment of medulloblastoma, reviewing the prognostic value and clinical application of molecular subtyping while highlighting the differences between adult and pediatric disease.



TÍTULO / TITLE:  - Current status of gene therapy for brain tumors.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Transl Res. 2012 Dec 11. pii: S1931-5244(12)00405-7. doi: 10.1016/j.trsl.2012.11.003.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.trsl.2012.11.003

AUTORES / AUTHORS:  - Murphy AM; Rabkin SD

INSTITUCIÓN / INSTITUTION:  - Brain Tumor Research Center, Molecular Neurosurgery Laboratory, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston,  Mass.

RESUMEN / SUMMARY:  - Glioblastoma (GBM) is the most common and deadliest primary brain tumor in adults, with current treatments having limited impact on disease progression. Therefore the development of alternative treatment options is greatly needed. Gene therapy is a treatment strategy that relies on the delivery of genetic material, usually transgenes or viruses, into cells for therapeutic purposes, and has been applied to GBM with increasing promise. We have included selectively replication-competent oncolytic viruses within this strategy, although the virus  acts directly as a complex biologic anti-tumor agent rather than as a classic gene delivery vehicle. GBM is a good candidate for gene therapy because tumors remain locally within the brain and only rarely metastasize to other tissues; the majority of cells in the brain are post-mitotic, which allows for specific targeting of dividing tumor cells; and tumors can often be accessed neurosurgically for administration of therapy. Delivery vehicles used for brain tumors include nonreplicating viral vectors, normal adult stem/progenitor cells,  and oncolytic viruses. The therapeutic transgenes or viruses are typically cytotoxic or express prodrug activating suicide genes to kill glioma cells, immunostimulatory to induce or amplify anti-tumor immune responses, and/or modify the tumor microenvironment such as blocking angiogenesis. This review describes current preclinical and clinical gene therapy strategies for the treatment of glioma.



TÍTULO / TITLE:  - Diabetes mellitus and risk of brain tumors: A meta-analysis.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Exp Ther Med. 2012 Nov;4(5):877-882. Epub 2012 Sep 6.

            ●● Enlace al texto completo (gratuito o de pago) 3892/etm.2012.698

AUTORES / AUTHORS:  - Tong JJ; Tao H; Hui OT; Jian C

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

RESUMEN / SUMMARY:  - Accumulating evidence suggests that a history of diabetes may be involved in the  occurrence of various types of cancer. However, the association of diabetes with  the risk of brain tumors remains unclear. We identified relevant studies by performing a literature search of PubMed and EMBASE (through to 24 May 2012) and  by searching the reference lists of pertinent articles. All data were extracted independently by two investigators using a standardized data abstraction tool. Summary relative risks (SRRs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Inter-study heterogeneity was assessed using the Cochran’s Q and I(2) statistical tests. A total of 13 studies were included in this meta-analysis, including the entire Danish population, 5,107,506 other participants and more than 2,206 cases of brain tumors. In the analysis of these  13 studies, we observed that diabetic individuals had a similar risk of brain tumors as non-diabetic individuals (SRR, 1.12; 95% CI, 0.89-1.42). There was significant evidence of heterogeneity among these studies (P<0.001; I(2), 93.5%). Sub-group analysis revealed that diabetic females had a 24.2% increased risk of brain tumors (SRR, 1.242; 95% CI, 1.026-1.502), which was not observed in diabetic males. No significant publication bias was found in this study. The findings of this meta-analysis indicate that diabetic individuals have a similar  risk of brain tumors as non-diabetic individuals. However, a significant positive correlation between the risk of brain tumors and diabetes mellitus was revealed in females, but not in males.



TÍTULO / TITLE:  - Diagnostic pitfalls in malignant gliomas: the analysis of misdiagnosis and current recommendations.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Chin Med J (Engl). 2012 Dec;125(24):4520-2.

AUTORES / AUTHORS:  - Wang Y; Guo Y; Gao J; Deng K; Li GL; Feng M; Wei JJ; Xu ZQ; Yao Y; Ma WB; Li YN; Yang Y; Wang RZ

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.




TÍTULO / TITLE:  - Strawberries on the brain. Intracranial capillary hemangioma: Two case reports and systematic literature review in children and adults.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - World Neurosurg. 2012 Dec 13. pii: S1878-8750(12)01445-3. doi: 10.1016/j.wneu.2012.12.013.

            ●● Enlace al texto completo (gratuito o de pago) 1016/j.wneu.2012.12.013

AUTORES / AUTHORS:  - Mirza B; Shi WY; Phadke R; Holton JL; Turner C; Plant GT; Brew S; Kitchen N; Zrinzo L

INSTITUCIÓN / INSTITUTION:  - Victor Horsley Department of Neurosurgery, The National Hospital for Neurology &  Neurosurgery, Queen Square, London, WC1N 3BG, UK. Electronic address: bilal.mirza@uclh.nhs.uk.

RESUMEN / SUMMARY:  - OBJECTIVE: Capillary hemangioma in the cranial cavity is rare. This report presents two additional cases with onset of symptoms in relation to pregnancy and provide a systematic review summarizing clinical experience to date. METHODS: Case reports were compiled retrospectively. Patient 1: A 28 year old woman presented with a simple partial seizure associated with left-sided visual distortions which progressed to a secondary generalised tonic clonic seizure. Imaging revealed a contrast-enhancing lesion in the right temporal region adjacent to the transverse sinus, with vasogenic edema and scalloping of the inner table. Angiographic appearance suggested the correct diagnosis. Patient 2:  A 41 year-old woman presented with progressive visual disturbance 6 months after  giving birth to her second child. Subtle symptoms of headache and visual disturbance had commenced during pregnancy. Non-contrasted imaging displayed a homogenous tumor with surrounding vasogenic edema in the occipital region. The publications on PubMed and Science Citation Index were reviewed systematically. RESULTS: Complete surgical excision was performed in both patients. Neuropathological examination confirmed benign capillary hemangioma consisting of a mesh-work of capillary sized and larger feeder vessels in both instances. The systematic review was based on 20 publications and clinical, radiological and surgical features together with the management were summarized. CONCLUSION: At follow-up, symptoms had disappeared and MRI confirmed complete removal in both patients. Intracranial capillary hemangioma is rare and treatment is empirical. Review of limited published reports suggested that surgery is the most commonly used treatment and that complete excision appears most likely to prevent further  recurrence.



TÍTULO / TITLE:  - Nerve sheath myxoma (neurothekeoma) of cerebellopontine angle: case report of a rare tumor with brief review of literature.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Turk Neurosurg. 2013;23(1):113-6. doi: 10.5137/1019-5149.JTN.4255-11.1.

            ●● Enlace al texto completo (gratuito o de pago) 5137/1019-5149.JTN.4255-11.1

AUTORES / AUTHORS:  - Vij M; Jaiswal S; Agrawal V; Jaiswal A; Behari S

INSTITUCIÓN / INSTITUTION:  - Christian Medical College, Department of Pathology, Vellore, India.

RESUMEN / SUMMARY:  - Nerve sheath myxoma (neurothekeoma) are rare benign nerve sheath tumors, usually  arising in the skin of the head and neck region and upper extremities in young females. To the best of author’s knowledge only two cases of intracranial neurothekeoma have been published in the English literature. These tumors were located in the parasellar area and in middle cranial fossa. This is the first case report of cerebellopontine angle neurothekeoma and third case report of intracranial neurothekeoma. This patient, a 45-year-old female, presented to us with complaints of right side progressive hearing loss for 12 months and swaying  during walking for 8 months. Histologically the tumor had lobular appearance with spindle or stellate cells embedded in abundant myxoid background. The tumor cells were diffusely positive for S100. The patient was symptom free at eight month follow up.



TÍTULO / TITLE:  - Coil embolization of an intracranial aneurysm in an infant with tuberous sclerosis complex: A case report and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Surg Neurol Int. 2012;3:129. doi: 10.4103/2152-7806.102944. Epub 2012 Oct 27.

            ●● Enlace al texto completo (gratuito o de pago) 4103/2152-7806.102944

AUTORES / AUTHORS:  - Yi JL; Galgano MA; Tovar-Spinoza Z; Deshaies EM

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, USA.

RESUMEN / SUMMARY:  - BACKGROUND: Tuberous sclerosis (TS) is a multiorgan neurocutaneous syndrome. Vascular manifestations are often extracranial. There is a paucity of cases involving TS combined with intracranial aneurysms reported in the literature. As  a result, treatment has not been well described. CASE DESCRIPTION: We report the  case of a 13-month-old female infant with a prior diagnosis of TS that was found  to have new onset of left eye ptosis, anisocoria, and papillary mydriasis indicative of left third cranial nerve palsy. A magnetic resonance angiogram (MRA) of the brain revealed a left internal carotid artery (ICA) aneurysm. Endovascular embolization was determined to be the best option for treatment. After a successful balloon test occlusion with neuromonitoring, the left internal carotid artery was sacrificed via coil embolization. CONCLUSIONS: This is only the third case report of endovascular coil embolization of an intracranial aneurysm in an infant with TS. We report no complications during the procedure, and the patient was discharged with resolving left third cranial nerve palsy. Neither surgical nor endovascular outcomes have been well described in the literature. Follow-up on this patient will be useful for establishing protocols of treatment.



TÍTULO / TITLE:  - Pancreatic paraganglioma: A case report of CT manifestations and literature review.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - Quant Imaging Med Surg. 2011 Dec;1(1):41-3. doi: 10.3978/j.issn.2223-4292.2011.08.02.

            ●● Enlace al texto completo (gratuito o de pago) 3978/j.issn.2223-4292.2011.08.02

AUTORES / AUTHORS:  - He J; Zhao F; Li H; Zhou K; Zhu B

INSTITUCIÓN / INSTITUTION:  - Department of Radiology, Nanjing Drum Tower Hospital, the Affiliated Hospital of  Nanjing University Medical School, Nanjing, China;

RESUMEN / SUMMARY:  - Paragangliomas are rare tumors arising from paraganglia (or chromaffin bodies) within the ganglia of the sympathetic trunk and the ganglia of the celiac, renal, suprarenal, aortic and hypogastric plexuses. These tumors can be widely distributed from skull base to the bottom of pelvis. Paraganglioma originating from pancreas is extremely rare. Here we report a 40-year-old female patient with paraganglioma located in the pancreatic head as a solid, well-demarcated mass with substantial enhancement on contrast-enhanced CT examination. Relevant literatures are also reviewed.



TÍTULO / TITLE:  - Management of pediatric colloid cysts of anterior third ventricle: A review of five cases.

RESUMEN / SUMMARY:  - Enlace al Resumen / Link to its Summary

REVISTA / JOURNAL:  - J Pediatr Neurosci. 2012 May;7(2):90-5. doi: 10.4103/1817-1745.102563.

            ●● Enlace al texto completo (gratuito o de pago) 4103/1817-1745.102563

AUTORES / AUTHORS:  - Kapu R; Symss NP; Pande A; Vasudevan MC; Ramamurthi R

INSTITUCIÓN / INSTITUTION:  - Department of Neurosurgery, Post Graduate Institute of Neurological Surgery, Dr.  A. Lakshmipathi Neurosurgical Centre, VHS Hospital, Chennai, Tamil Nadu, India.

RESUMEN / SUMMARY:  - OBJECT: Colloid cysts are congenital benign lesions, associated with more aggressive clinical and radiological picture in children than in adults. We present our experience in management of five pediatric patients with colloid cyst of the anterior third ventricle. They have an excellent chance of surgical cure,  or they can be devastating and even fatal, if not recognized on time and treated. MATERIALS AND METHODS: Five pediatric patients (aged 16 years or less) who were surgically treated for a colloid cyst, between 1987 and 2011 were analyzed. The clinical features included raised intracranial pressure in all five cases, of which one patient was brought unconscious with decerebrate posturing. Computed Tomography (CT) scan of the brain was done in all patients. The density of the lesion, enhancement with contrast and the presence of hydrocephalus were analyzed. Four patients underwent a detailed postoperative neurological assessment. RESULTS: Three patients underwent the transcallosal-transforaminal approach and total excision of the lesion. One patient underwent revision of the  pre-existing ventriculoperitoneal shunt. One patient who was brought in an unconscious state, an external ventricular drain was inserted and she was ventilated. She died 4 hours after the admission. On follow-up, none of the three patients who underwent the transcallosal-transforaminal approach had disconnection syndromes or behavioral disturbances. CONCLUSION: Colloid cysts in  children are rarer and more aggressive than their adult counterparts. It is surgically curable. Early detection and total excision of the lesion is a permanent cure with minimum morbidity, when compared with the natural history of  the disease. The limited anterior callosotomy does not result in disconnection syndromes or behavioral disturbance.